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Aliases for NSG1 Gene

Aliases for NSG1 Gene

  • Neuron Specific Gene Family Member 1 3
  • Neuron-Specific Protein Family Member 1 3 5
  • Brain Neuron Cytoplasmic Protein 1 3 4
  • D4S234 3 4
  • Carboxyterminally EE-Tagged Neuron-Enriched Endosomal 21 KDa Protein 3
  • D4S234E 3
  • NEEP21 3
  • P21 3

External Ids for NSG1 Gene

Summaries for NSG1 Gene

GeneCards Summary for NSG1 Gene

NSG1 (Neuron Specific Gene Family Member 1) is a Protein Coding gene. GO annotations related to this gene include clathrin light chain binding. An important paralog of this gene is HMP19.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSG1 Gene

Genomics for NSG1 Gene

Regulatory Elements for NSG1 Gene

Enhancers for NSG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F004347 0.2 ENCODE 44 +0.5 506 1.4 SRF ZNF316 EMSY ZIC2 MAFK NSG1 TMEM128 LYAR STX18-IT1
GH04F004396 1.1 Ensembl ENCODE 24.4 +48.6 48618 1.0 ZNF146 RFX1 SMARCA4 POLR2A RFXANK ZMYM3 MLLT1 EGR2 NSG1 STX18-IT1
GH04F004471 1.2 FANTOM5 Ensembl ENCODE 20.3 +125.1 125132 3.1 ELF3 MLX ZFP64 ARID4B DMAP1 DNMT3B RARA GATA4 FOS CREM NSG1 TMEM128 STX18-IT1
GH04F004426 0.6 ENCODE 20 +79.2 79202 1.2 CTCF ZNF341 MAX CTBP2 NSG1 TMEM128 STX18-IT1
GH04F004502 0.9 Ensembl ENCODE 18.9 +155.0 154961 1.0 WRNIP1 ZBTB48 POLR2A STAT2 ZNF600 ZBTB20 MTA2 CEBPB CEBPA IKZF1 NSG1 RPS7P15 PIR62291
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NSG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NSG1 Gene

Chromosome:
4
Start:
4,348,140 bp from pter
End:
4,419,058 bp from pter
Size:
70,919 bases
Orientation:
Plus strand

Genomic View for NSG1 Gene

Genes around NSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSG1 Gene

Proteins for NSG1 Gene

  • Protein details for NSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42857-NSG1_HUMAN
    Recommended name:
    Neuron-specific protein family member 1
    Protein Accession:
    P42857
    Secondary Accessions:
    • B4DXC5
    • Q49AQ1

    Protein attributes for NSG1 Gene

    Size:
    185 amino acids
    Molecular mass:
    20913 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NSG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NSG1 Gene

Post-translational modifications for NSG1 Gene

  • Glycosylation at Thr 145
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NSG1 Gene

Domains & Families for NSG1 Gene

Protein Domains for NSG1 Gene

Graphical View of Domain Structure for InterPro Entry

P42857

UniProtKB/Swiss-Prot:

NSG1_HUMAN :
  • Belongs to the NSG family.
Family:
  • Belongs to the NSG family.
genes like me logo Genes that share domains with NSG1: view

No data available for Gene Families for NSG1 Gene

Function for NSG1 Gene

Gene Ontology (GO) - Molecular Function for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0032051 clathrin light chain binding IEA,IBA --
genes like me logo Genes that share ontologies with NSG1: view

Phenotypes for NSG1 Gene

genes like me logo Genes that share phenotypes with NSG1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NSG1

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSG1 Gene

Localization for NSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSG1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus TAS 9013775
GO:0005737 cytoplasm TAS 9013775
GO:0005768 endosome IEA,IBA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with NSG1: view

No data available for Subcellular locations from COMPARTMENTS for NSG1 Gene

Pathways & Interactions for NSG1 Gene

SuperPathways for NSG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IEA --
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0016197 endosomal transport IEA,IBA --
GO:0048268 clathrin coat assembly IEA,IBA --
genes like me logo Genes that share ontologies with NSG1: view

No data available for Pathways by source and SIGNOR curated interactions for NSG1 Gene

Transcripts for NSG1 Gene

mRNA/cDNA for NSG1 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NSG1 Gene

Neuron specific gene family member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NSG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSG1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - - - - -
SP9:

Relevant External Links for NSG1 Gene

GeneLoc Exon Structure for
NSG1

Expression for NSG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NSG1 Gene

mRNA differential expression in normal tissues according to GTEx for NSG1 Gene

This gene is overexpressed in Pituitary (x5.6) and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for NSG1 Gene

This gene is overexpressed in Lung (52.9) and Fetal Brain (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NSG1 Gene



Protein tissue co-expression partners for NSG1 Gene

SOURCE GeneReport for Unigene cluster for NSG1 Gene:

Hs.518595
genes like me logo Genes that share expression patterns with NSG1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NSG1 Gene

Orthologs for NSG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NSG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToOne
LOC461091 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 94 (a)
OneToOne
NSG1 34
  • 84.78 (n)
mouse
(Mus musculus)
Mammalia Nsg1 34 16 35
  • 93.15 (n)
rat
(Rattus norvegicus)
Mammalia Nsg1 34
  • 92.79 (n)
cow
(Bos Taurus)
Mammalia NSG1 34 35
  • 92.25 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves NSG1 34 35
  • 81.44 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nsg1 34
  • 75.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18146 34
zebrafish
(Danio rerio)
Actinopterygii caly 35
  • 48 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4529 34
Species where no ortholog for NSG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSG1 Gene

ENSEMBL:
Gene Tree for NSG1 (if available)
TreeFam:
Gene Tree for NSG1 (if available)

Paralogs for NSG1 Gene

Paralogs for NSG1 Gene

(4) SIMAP similar genes for NSG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NSG1: view

Variants for NSG1 Gene

Sequence variations from dbSNP and Humsavar for NSG1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10002237 -- 4,417,884(+) GCCAT(C/T)AGCGG utr-variant-3-prime
rs10008550 -- 4,384,861(+) CTGCA(C/G)GCACC intron-variant, upstream-variant-2KB
rs10010062 -- 4,383,502(+) ttgcc(C/T)gaagt intron-variant
rs10015223 -- 4,387,147(+) GCGCT(C/G)AGCTG intron-variant, utr-variant-5-prime
rs10016025 -- 4,385,112(+) CCCAA(C/T)GACCA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NSG1 Gene

Variant ID Type Subtype PubMed ID
dgv8930n54 CNV loss 21841781
esv25965 CNV loss 19812545
esv2726967 CNV deletion 23290073
esv34196 OTHER inversion 12058347
nsv1150129 CNV deletion 26484159
nsv292541 CNV deletion 16902084
nsv436440 CNV deletion 17901297
nsv473665 CNV novel sequence insertion 20440878

Variation tolerance for NSG1 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NSG1 Gene

Disorders for NSG1 Gene

Relevant External Links for NSG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NSG1

No disorders were found for NSG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSG1 Gene

Publications for NSG1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons. (PMID: 9013775) Carlock L. … Dunbar J.C. (Brain Res. Mol. Brain Res. 1996) 3 4 64
  4. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking. (PMID: 25376768) Muthusamy N. … Bergson C. (J. Neurochem. 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for NSG1 Gene

Sources for NSG1 Gene

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