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Aliases for NSG1 Gene

Aliases for NSG1 Gene

  • Neuronal Vesicle Trafficking Associated 1 2 3
  • Neuron-Enriched Endosomal Protein Of 21 KD 2 3
  • Neuron-Specific Protein Family Member 1 3 5
  • Neuron Specific Gene Family Member 1 2 3
  • Brain Neuron Cytoplasmic Protein 1 3 4
  • D4S234 3 4
  • Carboxyterminally EE-Tagged Neuron-Enriched Endosomal 21 KDa Protein 3
  • DNA Segment On Chromosome 4 (Unique) 234 Expressed Sequence 2
  • HGNC:18790 5
  • D4S234E 3
  • NEEP21 3
  • P21 3

External Ids for NSG1 Gene

Summaries for NSG1 Gene

GeneCards Summary for NSG1 Gene

NSG1 (Neuronal Vesicle Trafficking Associated 1) is a Protein Coding gene. GO annotations related to this gene include clathrin light chain binding. An important paralog of this gene is NSG2.

Additional gene information for NSG1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSG1 Gene

Genomics for NSG1 Gene

Regulatory Elements for NSG1 Gene

Enhancers for NSG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H004471 1.4 FANTOM5 Ensembl ENCODE 20.3 +125.0 125010 2 ELF3 MLX ZFP64 ARID4B DMAP1 DNMT3B RARA FOS CREM MIXL1 NSG1 TMEM128 STX18-IT1
GH04H004347 0.5 ENCODE 44 +0.5 506 1 ZNF316 EMSY ZIC2 NSG1 TMEM128 LYAR STX18-IT1
GH04H004460 0.9 ENCODE 18.7 +114.0 113986 3 ELF3 FOXA2 MLX ARID4B RAD21 THRB ZBTB40 ZSCAN9 RARA YY1 NSG1 STX18-IT1
GH04H004396 0.6 ENCODE 24.4 +48.6 48618 1 MXI1 RFX1 POLR2A RFXANK MLLT1 EGR2 NSG1 STX18-IT1
GH04H004521 1.8 VISTA 7.9 +173.6 173592 1 IKZF1 NBN PRDM10 MLLT1 RUNX3 IKZF2 NSG1 RPS7P15 STX18-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NSG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NSG1 Gene

Chromosome:
4
Start:
4,348,140 bp from pter
End:
4,419,058 bp from pter
Size:
70,919 bases
Orientation:
Plus strand

Genomic View for NSG1 Gene

Genes around NSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSG1 Gene

Proteins for NSG1 Gene

  • Protein details for NSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42857-NSG1_HUMAN
    Recommended name:
    Neuron-specific protein family member 1
    Protein Accession:
    P42857
    Secondary Accessions:
    • B4DXC5
    • Q49AQ1

    Protein attributes for NSG1 Gene

    Size:
    185 amino acids
    Molecular mass:
    20913 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NSG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NSG1 Gene

Post-translational modifications for NSG1 Gene

  • Glycosylation at Thr145
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NSG1 Gene

Domains & Families for NSG1 Gene

Gene Families for NSG1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NSG1 Gene

Graphical View of Domain Structure for InterPro Entry

P42857

UniProtKB/Swiss-Prot:

NSG1_HUMAN :
  • Belongs to the NSG family.
Family:
  • Belongs to the NSG family.
genes like me logo Genes that share domains with NSG1: view

Function for NSG1 Gene

Phenotypes From GWAS Catalog for NSG1 Gene

Gene Ontology (GO) - Molecular Function for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0032051 clathrin light chain binding IBA --
genes like me logo Genes that share ontologies with NSG1: view

Phenotypes for NSG1 Gene

genes like me logo Genes that share phenotypes with NSG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NSG1
  • Applied Biological Materials Clones for NSG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSG1 Gene

Localization for NSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSG1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSG1 gene
Compartment Confidence
nucleus 5
endosome 4
plasma membrane 3
golgi apparatus 3
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus TAS 9013775
GO:0005737 cytoplasm TAS 9013775
GO:0005768 endosome IBA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with NSG1: view

Pathways & Interactions for NSG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IEA --
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0016197 endosomal transport IBA --
GO:0048268 clathrin coat assembly IBA --
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with NSG1: view

No data available for Pathways by source and SIGNOR curated interactions for NSG1 Gene

Drugs & Compounds for NSG1 Gene

No Compound Related Data Available

Transcripts for NSG1 Gene

mRNA/cDNA for NSG1 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NSG1 Gene

Neuron specific gene family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NSG1
  • Applied Biological Materials Clones for NSG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NSG1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - - - - -
SP9:

Relevant External Links for NSG1 Gene

GeneLoc Exon Structure for
NSG1
ECgene alternative splicing isoforms for
NSG1

Expression for NSG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NSG1 Gene

mRNA differential expression in normal tissues according to GTEx for NSG1 Gene

This gene is overexpressed in Pituitary (x5.6) and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for NSG1 Gene

This gene is overexpressed in Lung (52.9) and Fetal Brain (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NSG1 Gene



Protein tissue co-expression partners for NSG1 Gene

SOURCE GeneReport for Unigene cluster for NSG1 Gene:

Hs.518595

Evidence on tissue expression from TISSUES for NSG1 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with NSG1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NSG1 Gene

Orthologs for NSG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NSG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToOne
LOC461091 33
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
OneToOne
NSG1 33
  • 84.78 (n)
mouse
(Mus musculus)
Mammalia Nsg1 33 16 34
  • 93.15 (n)
rat
(Rattus norvegicus)
Mammalia Nsg1 33
  • 92.79 (n)
cow
(Bos Taurus)
Mammalia NSG1 33 34
  • 92.25 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves NSG1 33 34
  • 81.44 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nsg1 33
  • 75.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18146 33
zebrafish
(Danio rerio)
Actinopterygii caly 34
  • 48 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4529 33
Species where no ortholog for NSG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSG1 Gene

ENSEMBL:
Gene Tree for NSG1 (if available)
TreeFam:
Gene Tree for NSG1 (if available)

Paralogs for NSG1 Gene

Paralogs for NSG1 Gene

(4) SIMAP similar genes for NSG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NSG1: view

Variants for NSG1 Gene

Sequence variations from dbSNP and Humsavar for NSG1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000101417 -- 4,416,706(+) CAGCC(C/G)CTAGT intron-variant
rs10002237 -- 4,417,884(+) GCCAT(C/T)AGCGG utr-variant-3-prime
rs1000245748 -- 4,400,245(+) TGGCC(C/T)CCTTA intron-variant
rs1000310322 -- 4,411,054(+) TTTCA(C/T)CATGT intron-variant, upstream-variant-2KB
rs1000457234 -- 4,394,648(+) GACGG(A/T)ACTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSG1 Gene

Variant ID Type Subtype PubMed ID
dgv8930n54 CNV loss 21841781
esv25965 CNV loss 19812545
esv2726967 CNV deletion 23290073
esv34196 OTHER inversion 12058347
nsv1150129 CNV deletion 26484159
nsv292541 CNV deletion 16902084
nsv436440 CNV deletion 17901297
nsv473665 CNV novel sequence insertion 20440878

Variation tolerance for NSG1 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NSG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NSG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSG1 Gene

Disorders for NSG1 Gene

Relevant External Links for NSG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NSG1

No disorders were found for NSG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSG1 Gene

Publications for NSG1 Gene

  1. Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons. (PMID: 9013775) Carlock L … Dunbar JC (Brain research. Molecular brain research 1996) 2 3 4 60
  2. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking. (PMID: 25376768) Muthusamy N … Bergson C (Journal of neurochemistry 2015) 2 3 60
  3. The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM. (PMID: 18299352) Yap CC … Winckler B (The Journal of cell biology 2008) 2 3 60
  4. Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2. (PMID: 16037816) Steiner P … Hirling H (The EMBO journal 2005) 2 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for NSG1 Gene

  • Addgene plasmids for NSG1

Sources for NSG1 Gene

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