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Aliases for NSG1 Gene

Aliases for NSG1 Gene

  • Neuron Specific Gene Family Member 1 3 5
  • Brain Neuron Cytoplasmic Protein 1 3 4
  • D4S234 3 4
  • Carboxyterminally EE-Tagged Neuron-Enriched Endosomal 21 KDa Protein 3
  • D4S234E 3
  • NEEP21 3
  • P21 3

External Ids for NSG1 Gene

Summaries for NSG1 Gene

GeneCards Summary for NSG1 Gene

NSG1 (Neuron Specific Gene Family Member 1) is a Protein Coding gene. GO annotations related to this gene include clathrin light chain binding. An important paralog of this gene is HMP19.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSG1 Gene

Genomics for NSG1 Gene

Genomic Location for NSG1 Gene

Chromosome:
4
Start:
4,348,140 bp from pter
End:
4,419,058 bp from pter
Size:
70,919 bases
Orientation:
Plus strand

Genomic View for NSG1 Gene

Genes around NSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSG1 Gene

No data available for Regulatory Elements for NSG1 Gene

Proteins for NSG1 Gene

  • Protein details for NSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42857-NSG1_HUMAN
    Recommended name:
    Neuron-specific protein family member 1
    Protein Accession:
    P42857
    Secondary Accessions:
    • B4DXC5
    • Q49AQ1

    Protein attributes for NSG1 Gene

    Size:
    185 amino acids
    Molecular mass:
    20913 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NSG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NSG1 Gene

Proteomics data for NSG1 Gene at MOPED

Post-translational modifications for NSG1 Gene

  • Glycosylation at Thr 145
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NSG1 Gene

Domains & Families for NSG1 Gene

Protein Domains for NSG1 Gene

Graphical View of Domain Structure for InterPro Entry

P42857

UniProtKB/Swiss-Prot:

NSG1_HUMAN :
  • Belongs to the NSG family.
Family:
  • Belongs to the NSG family.
genes like me logo Genes that share domains with NSG1: view

No data available for Gene Families for NSG1 Gene

Function for NSG1 Gene

Gene Ontology (GO) - Molecular Function for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NSG1: view

Phenotypes for NSG1 Gene

GenomeRNAi human phenotypes for NSG1:
genes like me logo Genes that share phenotypes with NSG1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSG1 Gene

Localization for NSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSG1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0016021 integral component of membrane IEA --
GO:0016328 lateral plasma membrane IEA --
genes like me logo Genes that share ontologies with NSG1: view

No data available for Subcellular locations from COMPARTMENTS for NSG1 Gene

Pathways & Interactions for NSG1 Gene

SuperPathways for NSG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007212 dopamine receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NSG1: view

No data available for Pathways by source and SIGNOR curated interactions for NSG1 Gene

Drugs & Compounds for NSG1 Gene

No Compound Related Data Available

Transcripts for NSG1 Gene

mRNA/cDNA for NSG1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NSG1 Gene

Neuron specific gene family member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSG1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8: - - - - - -
SP9:

Relevant External Links for NSG1 Gene

GeneLoc Exon Structure for
NSG1

Expression for NSG1 Gene

mRNA expression in normal human tissues for NSG1 Gene

mRNA differential expression in normal tissues according to GTEx for NSG1 Gene

This gene is overexpressed in Pituitary (x5.6) and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for NSG1 Gene

This gene is overexpressed in Lung (52.9) and Fetal Brain (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NSG1 Gene



SOURCE GeneReport for Unigene cluster for NSG1 Gene Hs.518595

genes like me logo Genes that share expression patterns with NSG1: view

Protein tissue co-expression partners for NSG1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NSG1 Gene

Orthologs for NSG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NSG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC461091 35
  • 99.82 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NSG1 36
  • 98 (a)
OneToOne
NSG1 35
  • 92.25 (n)
  • 98.38 (a)
dog
(Canis familiaris)
Mammalia NSG1 35
  • 84.78 (n)
  • 87.86 (a)
-- 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nsg1 16
Nsg1 36
  • 98 (a)
OneToOne
Nsg1 35
  • 93.15 (n)
  • 98.38 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nsg1 35
  • 92.79 (n)
  • 98.92 (a)
chicken
(Gallus gallus)
Aves NSG1 36
  • 89 (a)
OneToOne
NSG1 35
  • 81.44 (n)
  • 88.65 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18146 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nsg1 35
  • 75.32 (n)
  • 82.7 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4529 35
zebrafish
(Danio rerio)
Actinopterygii caly 36
  • 48 (a)
ManyToMany
Species with no ortholog for NSG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSG1 Gene

ENSEMBL:
Gene Tree for NSG1 (if available)
TreeFam:
Gene Tree for NSG1 (if available)

Paralogs for NSG1 Gene

Paralogs for NSG1 Gene

(4) SIMAP similar genes for NSG1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NSG1: view

Variants for NSG1 Gene

Sequence variations from dbSNP and Humsavar for NSG1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs12550 -- 4,417,735(+) ATATG(C/T)GAAGG utr-variant-3-prime
rs14951 -- 4,418,394(+) GATAT(A/C)CCTTG utr-variant-3-prime
rs1131300 -- 4,417,755(+) TCAGA(A/T)AAATG utr-variant-3-prime
rs4234746 -- 4,403,116(+) CACTC(A/G)CTGAA intron-variant
rs4234747 -- 4,403,175(+) CCCTC(A/G)GGGGC intron-variant

Variation tolerance for NSG1 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NSG1 Gene

HapMap Linkage Disequilibrium report
NSG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NSG1 Gene

Disorders for NSG1 Gene

No disorders were found for NSG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for NSG1 Gene

Publications for NSG1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking. (PMID: 25376768) Muthusamy N. … Bergson C. (J. Neurochem. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Identification of NEEP21 as a A9-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro. (PMID: 21084623) Norstrom E.M. … Sisodia S.S. (J. Neurosci. 2010) 3

Products for NSG1 Gene

Sources for NSG1 Gene

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