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Aliases for NSFL1C Gene

Aliases for NSFL1C Gene

  • NSFL1 (P97) Cofactor (P47) 2 3
  • UBX Domain-Containing Protein 2C 3 4
  • P97 Cofactor P47 3 4
  • UBXN2C 3 4
  • P47 3 6
  • SHP1 Homolog (S. Cerevisiae) 2
  • UBX Domain Protein 2C 2
  • NSFL1 Cofactor P47 3
  • SHP1 Homolog 3
  • DJ776F14.1 3
  • UBXD10 3
  • UBX1 3

External Ids for NSFL1C Gene

Previous GeneCards Identifiers for NSFL1C Gene

  • GC20U990055
  • GC20M001371
  • GC20M001417
  • GC20M001372
  • GC20M001422

Summaries for NSFL1C Gene

Entrez Gene Summary for NSFL1C Gene

  • N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]

GeneCards Summary for NSFL1C Gene

NSFL1C (NSFL1 (P97) Cofactor (P47)) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include lipid binding. An important paralog of this gene is UBXN2B.

UniProtKB/Swiss-Prot for NSFL1C Gene

  • Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).

Gene Wiki entry for NSFL1C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSFL1C Gene

Genomics for NSFL1C Gene

Regulatory Elements for NSFL1C Gene

Genomic Location for NSFL1C Gene

1,442,162 bp from pter
1,473,842 bp from pter
31,681 bases
Minus strand

Genomic View for NSFL1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSFL1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSFL1C Gene

Proteins for NSFL1C Gene

  • Protein details for NSFL1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NSFL1 cofactor p47
    Protein Accession:
    Secondary Accessions:
    • A2A2L1
    • B2RD74
    • Q5JXA4
    • Q5JXA5
    • Q7Z533
    • Q9H102
    • Q9NVL9
    • Q9UI06

    Protein attributes for NSFL1C Gene

    370 amino acids
    Molecular mass:
    40573 Da
    Quaternary structure:
    • Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP (By similarity).
    • Sequence=AAF17199.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF17199.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NSFL1C Gene

    Alternative splice isoforms for NSFL1C Gene


neXtProt entry for NSFL1C Gene

Proteomics data for NSFL1C Gene at MOPED

Post-translational modifications for NSFL1C Gene

  • Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis (By similarity).
  • Ubiquitination at Lys112, Lys113, Lys124, Lys127, Lys146, Lys172, Lys188, Lys251, and Lys259
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NSFL1C Gene

Domains for NSFL1C Gene

Gene Families for NSFL1C Gene

  • UBXN :UBX domain containing

Protein Domains for NSFL1C Gene

Suggested Antigen Peptide Sequences for NSFL1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UNZ2
  • Contains 1 SEP domain.
  • Contains 1 UBX domain.
  • Belongs to the NSFL1C family.
genes like me logo Genes that share domains with NSFL1C: view

Function for NSFL1C Gene

Molecular function for NSFL1C Gene

UniProtKB/Swiss-Prot Function: Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).

Gene Ontology (GO) - Molecular Function for NSFL1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275660
GO:0008289 lipid binding IEA --
GO:0008599 protein phosphatase type 1 regulator activity IBA --
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with NSFL1C: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NSFL1C Gene

Localization for NSFL1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSFL1C Gene

Nucleus. Golgi apparatus, Golgi stack. Chromosome. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for NSFL1C Gene COMPARTMENTS Subcellular localization image for NSFL1C gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NSFL1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with NSFL1C: view

Pathways for NSFL1C Gene

genes like me logo Genes that share pathways with NSFL1C: view

Pathways by source for NSFL1C Gene

1 KEGG pathway for NSFL1C Gene

Gene Ontology (GO) - Biological Process for NSFL1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0007030 Golgi organization IBA --
GO:0031468 nuclear envelope reassembly IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0050790 regulation of catalytic activity IBA --
genes like me logo Genes that share ontologies with NSFL1C: view

Transcripts for NSFL1C Gene

Unigene Clusters for NSFL1C Gene

NSFL1 (p97) cofactor (p47):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NSFL1C Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - -
SP8: - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - -
SP12: - - -
SP14: - - -

ExUns: 13b ^ 14a · 14b

Relevant External Links for NSFL1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSFL1C Gene

mRNA expression in normal human tissues for NSFL1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NSFL1C Gene

SOURCE GeneReport for Unigene cluster for NSFL1C Gene Hs.12865

genes like me logo Genes that share expressions with NSFL1C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NSFL1C Gene

Orthologs for NSFL1C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NSFL1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NSFL1C 35
  • 99.82 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia NSFL1C 35
  • 93.96 (n)
  • 96.76 (a)
  • 97 (a)
(Canis familiaris)
Mammalia NSFL1C 35
  • 93.91 (n)
  • 97.04 (a)
  • 97 (a)
(Mus musculus)
Mammalia Nsfl1c 35
  • 91.85 (n)
  • 96.24 (a)
Nsfl1c 16
Nsfl1c 36
  • 96 (a)
(Monodelphis domestica)
Mammalia NSFL1C 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Nsfl1c 35
  • 90.99 (n)
  • 96.49 (a)
(Gallus gallus)
Aves NSFL1C 35
  • 80.98 (n)
  • 88.32 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia NSFL1C 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5402 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10070 35
(Danio rerio)
Actinopterygii hmzehn2383 35
LOC100537232 35
  • 69.39 (n)
  • 73.3 (a)
nsfl1c 36
  • 72 (a)
nsfl1c 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005122 35
  • 51.07 (n)
  • 44.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42383 36
  • 25 (a)
p47 35
  • 49.18 (n)
  • 42.31 (a)
p47 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea ubxn-2 36
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR211C 35
  • 43.77 (n)
  • 31.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SHP1 35
  • 42.03 (n)
  • 32.78 (a)
SHP1 36
  • 22 (a)
SHP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20043g 35
  • 43.71 (n)
  • 34.58 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PUX4 35
  • 46.74 (n)
  • 39.84 (a)
(Oryza sativa)
Liliopsida Os04g0464500 35
  • 48.84 (n)
  • 38.37 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01100 35
  • 45.24 (n)
  • 33.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubx3 35
  • 43.58 (n)
  • 35.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2402 36
  • 44 (a)
Species with no ortholog for NSFL1C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NSFL1C Gene

Gene Tree for NSFL1C (if available)
Gene Tree for NSFL1C (if available)

Paralogs for NSFL1C Gene

Paralogs for NSFL1C Gene

Selected SIMAP similar genes for NSFL1C Gene using alignment to 7 proteins: Pseudogenes for NSFL1C Gene

genes like me logo Genes that share paralogs with NSFL1C: view

Variants for NSFL1C Gene

Sequence variations from dbSNP and Humsavar for NSFL1C Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs6891 -- 1,443,658(-) GTGCA(C/T)ACCCA utr-variant-3-prime, nc-transcript-variant
rs9575 - 1,445,748(-) TAATC(A/G)ACGAA missense, reference, nc-transcript-variant
rs13063 -- 1,443,203(-) GAGCT(A/C)CATGC utr-variant-3-prime, nc-transcript-variant
rs734782 -- 1,458,929(-) CACTG(C/G)TTTTT intron-variant
rs744805 -- 1,458,388(+) GAGAG(A/G)AGGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NSFL1C Gene

Variant ID Type Subtype PubMed ID
nsv522008 CNV Gain 19592680
nsv833893 CNV Loss 17160897
nsv3252 CNV Insertion 18451855

Relevant External Links for NSFL1C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSFL1C Gene

Disorders for NSFL1C Gene

No disorders were found for NSFL1C Gene.

No data available for UniProtKB/Swiss-Prot for NSFL1C Gene

Publications for NSFL1C Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. (PMID: 9506515) Rabouille C. … Warren G. (Cell 1998) 3 23
  4. VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. (PMID: 12473691) Uchiyama K. … Kondo H. (J. Cell Biol. 2002) 3 23
  5. The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle. (PMID: 12810701) Uchiyama K. … Kondo H. (J. Cell Biol. 2003) 3 23

Products for NSFL1C Gene

  • antibodies-online proteins for NSFL1C
  • antibodies-online antibodies for NSFL1C
  • antibodies-online kits for NSFL1C

Sources for NSFL1C Gene

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