Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NSFL1C Gene

protein-coding   GIFtS: 57
GCID: GC20M001422

NSFL1 (p97) cofactor (p47)
 Explore 2 diseases affiliated with
NSFL1C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NSFL1C    

Aliases
for NSFL1C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NSFL1 (P97) Cofactor (P47)1 2     UBX Domain-Containing Protein 2C2 3
UBXN2C1 2 3     P472 5
UBX11 2     P472 5
UBXD101 2     NSFL1 Cofactor P472
DJ776F14.11     SHP1 Homolog2
P97 Cofactor P472 3     

External Ids:    HGNC: 159121   Entrez Gene: 559682   Ensembl: ENSG000000888337   OMIM: 6066105   UniProtKB: Q9UNZ23   
ORGUL members:         
NONCODE:n410731    

Export aliases for NSFL1C gene to outside databases

Previous GC identifers: GC20U990055 GC20M001371 GC20M001417 GC20M001372


Summaries
for NSFL1C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NSFL1C:
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in
transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by
this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic
Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been
identified on chromosome 8. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: NSF1C_HUMAN, Q9UNZ2
Function: Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for
VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional
endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro)

Gene Wiki entry for NSFL1C


Genomic Views
for NSFL1C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NSFL1C gene promoter:
         AhR   Bach1   ER-alpha   POU6F1 (c2)   Arnt   E2F-1   E2F   USF-1   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NSFL1C promoter sequence
   Search SABiosciences Chromatin IP Primers for NSFL1C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NSFL1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

NSFL1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NSFL1C gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M001422:  view genomic region     (about GC identifiers)

Start:
 1,422,807 bp from pter      End:
 1,448,417 bp from pter
Size:
 25,611 bases      Orientation:
 minus strand

Proteins
for NSFL1C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NSF1C_HUMAN, Q9UNZ2 (See protein sequence)
Recommended Name: NSFL1 cofactor p47  
Size: 370 amino acids; 40573 Da
Subunit: Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of
a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes
Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds
ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP (By similarity)
Subcellular location: Nucleus (By similarity). Golgi apparatus, Golgi stack (By similarity). Chromosome (By
similarity). Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in
pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks (By
similarity)
Sequence caution: Sequence=AAF17199.1; Type=Frameshift; Positions=Several; Sequence=AAF17199.1; Type=Miscellaneous
discrepancy; Note=Sequencing errors;
1 PDB 3D structure from and Proteopedia for NSFL1C:
1SS6 (3D)    
Secondary accessions: A2A2L1 B2RD74 Q5JXA4 Q5JXA5 Q7Z533 Q9H102 Q9NVL9 Q9UI06
Alternative splicing: 4 isoforms:  Q9UNZ2-1   Q9UNZ2-4   Q9UNZ2-5   Q9UNZ2-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NSFL1C: NX_Q9UNZ2

Post-translational modifications:

  • Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the
    • fragmentation of the Golgi stacks during mitosis (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNZ2

    • NSFL1C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193665.1  NP_057227.2  NP_061327.2  

    ENSEMBL proteins: 
     ENSP00000338643   ENSP00000452019   ENSP00000418529   ENSP00000216879   ENSP00000434067  
     ENSP00000451675   ENSP00000202584   ENSP00000371074  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NSFL1C
    OriGene Protein Over-expression Lysate (see all 3): NSFL1C
    OriGene Custom Protein Services for NSFL1C 
    GenScript Custom Purified and Recombinant Proteins Services for NSFL1C
    Novus Biologicals NSFL1C Protein
    Novus Biologicals NSFL1C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NSFL1C

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005694chromosome IEA--
    GO:0005795Golgi stack IEA--


    NSFL1C for ontologies           About GeneDecksing



    NSFL1C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: NSFL1C
    OriGene Custom Antibody Services for NSFL1C 
    GenScript Custom Superior Antibodies Services for NSFL1C
    Novus Biologicals NSFL1C Antibodies
    Abcam antibodies for NSFL1C 
    Uscn Antibodies for NSFL1C
    ThermoFisher Antibody for NSFL1C

    Assay Products for NSFL1C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NSFL1C
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NSFL1C

    Protein Domains /
    Families
    for NSFL1C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NSFL1C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012989 SEP_domain
     IPR001012 UBX
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q9UNZ2

    ProtoNet protein and cluster: Q9UNZ2

    2 Blocks protein families:
    IPB001012 UBX domain
    IPB012989 SEP


    UniProtKB/Swiss-Prot: NSF1C_HUMAN, Q9UNZ2
    Similarity: Belongs to the NSFL1C family
    Similarity: Contains 1 SEP domain
    Similarity: Contains 1 UBX domain


    Function
    for NSFL1C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NSF1C_HUMAN, Q9UNZ2
    Function: Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for
    VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional
    endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro)

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): NSFL1C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NSFL1C
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate NSFL1C (see all 30):
    hsa-miR-194* hsa-miR-3689b hsa-miR-1288 hsa-miR-4299 hsa-miR-520a-5p hsa-miR-29b-1* hsa-miR-570 hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmid: NSFL1C 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSFL1C (see all 7)
    OriGene shRNA RFP: NSFL1C
    OriGene siRNA: NSFL1C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NSFL1C

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NSFL1C

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSFL1C (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSFL1C (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): NSFL1C (NM_016143)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NSFL1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSFL1C 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NSFL1C
    Search LifeMap BioReagents cell lines for NSFL1C

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSFL1C

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008289lipid binding IEA--


    NSFL1C for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Nsfl1c (no phenotypes)

    NSFL1C for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NSFL1C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for NSFL1C):
        Protein processing in endoplasmic reticulum


    NSFL1C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NSFL1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/141 Interacting proteins for NSFL1C (Q9UNZ22, 3 ENSP000002168794) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Drugs & Compounds
    for NSFL1C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NSFL1C
    Search CenterWatch for drugs/clinical trials and news about NSFL1C / NSF1C 

    Transcripts
    for NSFL1C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NSFL1C gene (4 alternative transcripts): 
    NM_001206736.1  NM_016143.4  NM_018839.4  NM_182483.1  

    Unigene Cluster for NSFL1C:

    NSFL1 (p97) cofactor (p47)
    Hs.12865  [show with all ESTs]
    Unigene Representative Sequence: AK128722
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461211 ENST00000353088 ENST00000555944 ENST00000476071 ENST00000216879(uc002wfc.3 uc021vzq.1 uc002wfe.3)
    ENST00000381653 ENST00000555568 ENST00000470376 ENST00000489203 ENST00000555359
    ENST00000487086 ENST00000478168 ENST00000350991 ENST00000381658

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): NSFL1C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NSFL1C
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate NSFL1C (see all 30):
    hsa-miR-194* hsa-miR-3689b hsa-miR-1288 hsa-miR-4299 hsa-miR-520a-5p hsa-miR-29b-1* hsa-miR-570 hsa-miR-378b
    SwitchGear 3'UTR luciferase reporter plasmid: NSFL1C 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSFL1C (see all 7)
    OriGene shRNA RFP: NSFL1C
    OriGene siRNA: NSFL1C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NSFL1C
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSFL1C (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSFL1C (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): NSFL1C (NM_016143)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NSFL1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSFL1C 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NSFL1C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NSFL1C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSFL1C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSFL1C

    Additional cDNA sequence: 

    AF078856.1 AF086909.1 AF283774.2 AK001511.1 AK023585.1 AK093845.1 AK128722.1 AK223334.1 
    AK223341.1 AK297403.1 AK315433.1 BC002801.2 NR_038164.1 

    23 DOTS entries:

    DT.40279064  DT.97803109  DT.86847386  DT.91774467  DT.40193022  DT.40303350  DT.95356421  DT.95356434 
    DT.100719239  DT.120798521  DT.120798775  DT.40285168  DT.91774458  DT.120798748  DT.95356419  DT.100877726 
    DT.120798751  DT.120798773  DT.91774466  DT.91774469  DT.95356430  DT.97773722  DT.92028153 

    24/470 AceView cDNA sequences (see all 470):

    CD300447 AA453246 AA905686 CA443302 BU728449 BI868563 BE857312 BI830016 
    BQ953021 BM826809 BM552497 AW178679 CR605903 BU740425 NM_016143 BM710920 
    BQ881326 CA445785 BM792389 AV709698 BE797085 BE796728 BG421659 AI368392 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for NSFL1C (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a ·
    SP1:                                -     -                 -     -     -                                                     -     -     -                     
    SP2:                                -     -                 -     -     -                                                     -                                 
    SP3:                                -     -                 -     -     -                       -                             -     -     -                     
    SP4:                                -     -                 -     -     -     -     -                                         -                                 
    SP5:                          -     -     -                 -     -     -     -     -                                         -     -     -                     

    ExUns: 13b ^ 14a · 14b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for NSFL1C

    Expression
    for NSFL1C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NSFL1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGATCGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NSFL1C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NSFL1C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NSFL1C

    SOURCE GeneReport for Unigene cluster: Hs.12865
        SABiosciences Custom PCR Arrays for NSFL1C
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NSFL1C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NSFL1C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSFL1C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSFL1C
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSFL1C

    Orthologs
    for NSFL1C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NSFL1C gene from 9/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NSFL1C1 NSFL1 (p97) cofactor (p47) 80.98(n)
    88.32(a)    		   419268  NM_001030859.1  NP_001026030.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NSFL1C6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343346.1(959897-978536)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC041297.12   -- 78.12(n)    BC041297.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hmzehn23832 hmzehn2383 75.52(n)   337763  CD760325.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta p471 CG11139-PA 49.08(n)
    42.31(a)    		   35674  NM_136440.5  NP_610284.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ubxn-21 Protein UBXN-2 45.71(n)
    40.53(a)    		   177057  NM_001028419.2  NP_001023590.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SHP1(YBL058W)4
    SHP11    		 UBX (ubiquitin regulatory X) domain-containing protein more4
    Shp1p1    		 41.44(n)1
    31.67(a)1    		   2(111437-112708)4
    8522221, 4  NP_009495.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PUX46
    PUX36
    (see all 4)    		 plant UBX domain-containing protein 3
    (see all 4)    		 32(a)
    26(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 4(2030319-2031853)
    4(11731138-11732901)
    rice
    (Oryza sativa)    		 Liliopsida Os06g06346001 hypothetical protein 47.54(n)
    38.07(a)    		   4341597  NM_001064673.1  NP_001058138.1 


    ENSEMBL Gene Tree for NSFL1C (if available)
    TreeFam Gene Tree for NSFL1C (if available) 

    Paralogs
    for NSFL1C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NSFL1C gene
    UBXN2A2  UBXN2B2  
    2 SIMAP similar genes for NSFL1C using alignment to 5 protein entries:     NSF1C_HUMAN (see all proteins):
    UBXN2A    UBXN2B

    NSFL1C for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NSFL1C
    PGOHUM00000249329


    Genomic Variants
    for NSFL1C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/485 NCBI SNPs in NSFL1C are shown (see all 485)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116997351,2
    		C,F,H,--1422348(+) TGGAAC/TCAGAC 4 -- ds500112Minor allele frequency- T:0.49NA WA EA 512
    rs1140438671,2
    		F,--1422399(+) AACTGT/CGGTGG 4 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1113904771,2
    		C,--1422453(+) TACTT-/CCCAGA 4 -- ds50011Minor allele frequency- C:0.00CSA 2
    rs1164503841,2
    		F,--1422472(+) GGGCCC/ATGTGC 4 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1842441721,2
    		--1422482(+) CAAACC/TACCGT 4 -- ds50010--------
    rs1888584251,2
    		--1422486(+) CTACCA/GTAGAT 4 -- ds50010--------
    rs1417396821,2
    		--1422567(+) AGAAGC/GAGGTA 4 -- ds50010--------
    rs1821223871,2
    		--1422617(+) GGATGA/GAGTGT 4 -- ds50010--------
    rs764688411,2
    		F,--1422753(+) AAGTAC/TTTCTG 4 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1847113541,2
    		--1422766(+) GGCTGC/TTGTAG 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for NSFL1C (1422807 - 1448417 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NSFL1C: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NSFL1C
    DNA2.0 Custom Variant and Variant Library Synthesis for NSFL1C

    Disorders / Diseases
    for NSFL1C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NSFL1C for disorders           About GeneDecksing

    OMIM gene information: 606610    OMIM disorders: --

    2 diseases for NSFL1C:    About MalaCards
    schizophrenia    malaria


    Export disorders for NSFL1C gene to outside databases

    Publications
    for NSFL1C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NSFL1C gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with NSFL1C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    7. The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle. (PubMed id 12810701)1, 9 Uchiyama K....Kondo H. (2003)
    8. Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro. (PubMed id 9506515)1, 9 Rabouille C....Warren G. (1998)
    9. VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo. (PubMed id 12473691)1, 9 Uchiyama K....Kondo H. (2002)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for NSFL1C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NSFL1C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55968 HGNC: 15912 AceView: NSFL1C Ensembl:ENSG00000088833 euGenes: HUgn55968
    ECgene: NSFL1C Kegg: 55968 H-InvDB: NSFL1C

    Other Databases showing NSFL1C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NSFL1C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NSFL1C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NSFL1C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NSFL1C gene:
    Search GeneIP for patents involving NSFL1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NSFL1C gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NSFL1C   OriGene shRNA RFP for NSFL1C  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSFL1C   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NSFL1C  
     OriGene Protein Over-expression Lysate for NSFL1C   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NSFL1C   OriGene 3'-UTR Clone for NSFL1C  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSFL1C   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSFL1C  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NSFL1C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NSFL1C   OriGene Custom Protein Services for NSFL1C  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NSFL1C
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NSFL1C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NSFL1C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NSFL1C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSFL1C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSFL1C
     GenScript Custom Purified and Recombinant Proteins Services for NSFL1C GenScript cDNA clones with any tag delivered in your preferred vector for NSFL1C
     GenScript Custom Assay Services for NSFL1C GenScript Custom Superior Antibodies Services for NSFL1C
     GenScript Custom overexpressing Cell Line Services for NSFL1C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NSFL1C promoter
     Search Chromatin IP Primers for NSFL1C
     RT2 qPCR Primer Assay in human, mouse, rat NSFL1C
     GNC Network for NSFL1C
     SABiosciences Custom PCR Arrays for NSFL1C
     Search Tocris compounds for NSFL1C
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NSFL1C antibodies
     NSFL1C proteins
     NSFL1C lysates
     Antibodies for NSFL1C
     See all of Abcam's Antibodies, Kits and Proteins for NSFL1C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NSFL1C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NSFL1C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSFL1C
     SwitchGear 3'UTR luciferase reporter plasmids for NSFL1C
     SwitchGear Promoter luciferase reporter plasmids for NSFL1C
     ThermoFisher Antibody for NSFL1C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSFL1C
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NSFL1C gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4