Aliases for NSFL1C Gene
External Ids for NSFL1C Gene
Previous GeneCards Identifiers for NSFL1C Gene
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]
GeneCards Summary for NSFL1C Gene
NSFL1C (NSFL1 (P97) Cofactor (P47)) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include lipid binding and protein phosphatase type 1 regulator activity. An important paralog of this gene is UBXN2B.
UniProtKB/Swiss-Prot for NSFL1C Gene
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).