NSF Gene
protein-coding GIFtS: 68
GCID: GC17P044668
|
|
N-ethylmaleimide-sensitive factor
| |
Aliases
for NSF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-Ethylmaleimide-Sensitive Factor1 2 | | NEM-Sensitive Fusion Protein2 3 | | SKD21 2 | | EC 3.6.4.63 8 | | Vesicular-Fusion Protein NSF2 3 | | N-Ethylmaleimide-Sensitive Factor-Like Protein2 | | N-Ethylmaleimide-Sensitive Fusion Protein2 3 | | Vesicle-Fusing ATPase2 |
Export aliases for NSF gene to outside databasesPrevious GC identifers: GC17P044205 GC17P047067 GC17P045050 GC17P045143 GC17P041805 GC17P042024 GC17P040092 |
Summaries
for NSF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NSF_HUMAN, P46459Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgicisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as afusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent ofvesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity)
Gene Wiki entry for NSF (N-ethylmaleimide sensitive fusion protein)
|
Genomic Views
for NSF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15 NT_167251.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NSF gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 POU2F1 POU2F1a POU2F1b AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for NSF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NSF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21NSF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P044668: view genomic region
(about GC identifiers)
Start:
|
44,668,035 bp from pter |
End:
|
44,834,833 bp from pter |
Size:
|
166,799 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+,ALT_REF_LOCI_9 44,833,684-44,886,326 |
|
Proteins
for NSF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NSF_HUMAN, P46459 (See
protein sequence)Recommended Name: Vesicle-fusing ATPase Size: 744 amino acids; 82594 Da
Cofactor: Binds 1 magnesium ion per subunit (By similarity)
Subunit: Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading todisrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity).Interacts with CDK16 (By similarity)
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAA17411.1; Type=Erroneous initiation;
Secondary accessions: A8K2D9 Q8N6D7 Q9UKZ2Explore the universe of human proteins at neXtProt for NSF: NX_P46459
Post-translational modifications:
Phosphorylation at Ser-569 interferes with homohexamerization (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P46459
4/17 DME Specific Peptides for NSF (P46459) (see all 17)
NSF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006169.2
ENSEMBL proteins: ENSP00000381293 ENSP00000459393 ENSP00000461448 ENSP00000460152 ENSP00000458184 ENSP00000458221 ENSP00000459646 ENSP00000467779 ENSP00000225282 Reactome Protein details: P46459
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NSF for ontologies About GeneDecksing
NSF Antibody Products:
Assay Products for NSF: |
Protein
Domains /
Families
for NSF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NSF for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P46459ProtoNet protein and cluster: P46459 3 Blocks protein families: IPB003338 AAA ATPase VAT IPB003960 AAA-protein subdomain IPB004201 Cell division protein 48
UniProtKB/Swiss-Prot: NSF_HUMAN, P46459Similarity: Belongs to the AAA ATPase family |
Function
for NSF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NSF_HUMAN, P46459Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgicisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as afusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent ofvesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity)Catalytic activity: ATP + H(2)O = ADP + phosphate Genatlas biochemistry entry for NSF:N-ethylmaleimide sensitive factor
Enzyme Number (IUBMB): EC 3.6.4.61 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NSF (NM_006178) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NSF | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSF |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSF |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
NSF for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NSF:
Animal Models:
1 MGI phenotypic allele  for Nsf (no phenotypes)
NSF for phenotypes About GeneDecksing
|
Pathways & Interactions
for NSF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transmission across Chemical Synapses | | | 2 | Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | | | 3 | Normal wtCFTR traffic / Sorting endosome formation | | | 4 | Clathrin-dependent protein traffic | | | 5 | Neuroscience | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NSF
2 
Cell Signaling Technology (CST) Pathways for NSF
3  GeneGo (Thomson Reuters) Pathways for NSF
1  BioSystems Pathway for NSF
5/6 
Reactome Pathways for NSF (see all 6)
1 
Kegg Pathway (Kegg details for NSF):
NSF for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NSF
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/1028 Interacting proteins for NSF (P464592, 3 ENSP000003812934) via UniProtKB, MINT, STRING, and/or I2D (see all 1028)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
NSF for ontologies About GeneDecksing
|
Drugs & Compounds
for NSF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NSF for compounds About GeneDecksing
 Browse Tocris compounds for NSF
5 HMDB Compounds for NSF About this table
1 DrugBank Compound for NSF About this table
10/23 Novoseek chemical compound relationships for NSF gene (see all 23) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| n-ethylmaleimide |
88.6 |
117 |
7812046 (3), 1999460 (2), 16165270 (2), 15037235 (2) (see all 60) |
| lm-a1 |
78.2 |
1 |
15037235 (1) |
| atpgammas |
59.2 |
3 |
11931741 (1), 15126634 (1) |
| atp |
58 |
65 |
8051214 (5), 8550603 (4), 7493945 (3), 9697855 (3) (see all 29) |
| sulfamethoxypyridazine |
57.6 |
1 |
15610906 (1) |
| mgatp |
37.3 |
2 |
9771883 (1), 8702751 (1) |
| glutamate |
30.1 |
10 |
9861668 (1), 15630087 (1), 15858065 (1), 16760338 (1) (see all 7) |
| nmda |
25.2 |
8 |
15944123 (2), 12441055 (2), 12011465 (1) |
| calcium |
23.3 |
26 |
7501022 (2), 9031603 (2), 10954749 (2), 7835334 (1) (see all 13) |
| phalloidin |
22.2 |
1 |
11404404 (1) |
Search CenterWatch for drugs/clinical trials and news about NSF
|
Transcripts
for NSF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NSF gene: NM_006178.3 Unigene Cluster for NSF: N-ethylmaleimide-sensitive factor Hs.431279 [show with all ESTs]Unigene Representative Sequence: NM_00617810 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398238(uc002iku.3 uc010wke.2 uc010wkf.2 uc010wkg.2)
ENST00000571510 ENST00000571864 ENST00000486366 ENST00000576040 ENST00000571172
ENST00000575068 ENST00000576346 ENST00000465370 ENST00000225282
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSF (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSF
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NSF (NM_006178) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NSF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSF |
Additional cDNA sequence: AF102846.2 AF135168.1 AK025172.1 AK226078.1 AK290204.1 AK294001.1 AK299031.1 AK299786.1 AK316057.1 AL049276.1 BC013314.2 BC030613.2 NR_040116.1 U03985.1 U80997.1 17 DOTS entries: DT.120982834 DT.418549 DT.120982824 DT.100822995 DT.92446651 DT.100822994 DT.120982980 DT.120982973 DT.120982699 DT.120982753 DT.40290597 DT.92446640 DT.100822992 DT.120983056 DT.40124453 DT.92446648 DT.95259723 10 AceView cDNA sequences: CB110309 BU431028 BQ934349 BP360498 AW500406 BM542647 AI014355 BM149063 AK025172 BI544287
GeneLoc Exon Structure
|
Expression
for NSF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NSF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCAGCAC
About this image
See NSF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NSF
SOURCE GeneReport for Unigene cluster: Hs.431279
SABiosciences Expression via Pathway-Focused PCR Arrays including NSF:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NSF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NSF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSF |
Orthologs
for NSF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NSF gene from 10/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Nsf1 , 5 |
N-ethylmaleimide sensitive fusion protein1, 5 |
89.2(n)1
98.12(a)1 |
|
11 (67.54 cM)5
181951 NM_008740.41 NP_032766.21
1038217825 |
chicken
(Gallus gallus) |
Aves |
NSF1 |
N-ethylmaleimide-sensitive factor |
81.71(n)
94.19(a) |
|
419972 NM_001024456.1 NP_001019627.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NSF6 |
-- |
91(a) |
1 ↔ 1 |
6(65479395-65542164) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.222462 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.62(n) |
|
CD252804.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj33g112 |
Danio rerio similar to N-ethylmaleimide-sensitive factor, more |
76.78(n) |
|
BC050490.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nsf21 , 3 |
ER to Golgi transport3
NEM-sensitive fusion protein 21 |
62(a)
(best of 2)3
60.32(n)1
63.81(a)1 |
|
3 87F153
416941 NM_176499.11 NP_788676.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
nsf-11 |
Protein NSF-1 |
57.29(n)
55.42(a) |
|
266842 NM_001083134.2 NP_001076603.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SEC18(YBR080C)4
SEC181 |
ATPase required for vesicular transport between ER more4
Sec18p1 |
52.44(n)1
47.51(a)1 |
|
2(400890-398614)4
8523721, 4 NP_009636.31 NP_009636.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NSF6 |
vesicle-fusing ATPase |
43(a) |
1 ↔ 1 |
4(2489417-2495766) |
rice
(Oryza sativa) |
Liliopsida |
Os.222802 |
Oryza sativa SS652 mRNA for SEC18, partial cds |
73.47(n) |
|
AK072976.1 |
ENSEMBL Gene Tree for NSF (if available)
TreeFam Gene Tree for NSF (if available) |
Paralogs
for NSF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NSF gene
4 SIMAP similar genes for NSF using alignment to 11 protein entries: NSF_HUMAN (see all proteins):PSMC1 VCP PSMC5 PSMC2
NSF for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NSF
PGOHUM00000237417
|
Genomic Variants
for NSF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NSF (44668035 - 44834833 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 32 variations for NSF
15/27 CNVs (see all 27): 88502 49872 72953 34570 8850 38843 0207 4038 0803 49870 49871 2228 30837 77634 0327
5 Indels: 88505 77637 77638 88504 77639 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NSF |
|
Disorders
/ Diseases
for NSF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NSF for disorders About GeneDecksing
OMIM gene information: 601633
OMIM disorders: --
20/23  diseases for NSF (see all 23): About MalaCardsneuronal intranuclear inclusion disease supranuclear palsy progressive supranuclear palsy transient cerebral ischemia
bipolar i disorder anorexia nervosa botulism tetanus
myocardial infarction thrombosis stomatitis parkinson's disease
ischemia cerebritis seizures schizophrenia
peritonitis cholesterol tuberculosis neuronitis
2 diseases from the University of Copenhagen DISEASES database for NSF:Botulism Tetanus 5 Novoseek disease relationships for NSF gene About this table
Genetic Association Database (GAD): NSF
Human Genome Epidemiology (HuGE) Navigator: NSF (8 documents)
Export disorders for NSF gene to outside databases
|
Publications
for NSF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NSF gene, integrated from 9 sources (see all 284):
(articles sorted by number of sources associating them with NSF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A multisubunit particle implicated in membrane fusion. (PubMed id 1315316)1, 3, 9 Wilson D.W....Rothman J.E. (1992)
- Novel haplotypes in 17q21 are associated with progressive supranuclear palsy. (PubMed id 15293277)1, 4 Pastor P....Goate A.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Localization of human and mouse N-ethylmaleimide-sens itive factor (NSF) gene: a two-domain member of the AAA family that is involved in membrane fusion. (PubMed id 8875895)1, 3 Hoyle J....Fisher E.M. (1996)
- N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion. (PubMed id 8051214)1, 9 Whiteheart S.W....Rothman J.E. (1994)
- N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex. (PubMed id 9325254)1, 9 Subramaniam V.N....Hong W. (1997)
- N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes. (PubMed id 17510209)1, 9 Wang Y....Xiang Y. (2007)
- The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin. (PubMed id 7622514)1, 9 Hanson P.I....Jahn R. (1995)
- PTP1B dephosphorylates N-ethylmaleimide-sensitive factor and elicits SNARE complex disassembly during human sperm exocytosis. (PubMed id 19208619)1, 9 Zarelli V.E....Tomes C.N. (2009)
- Control of vesicle fusion by a tyrosine phosphatase. (PubMed id 15322554)1, 9 Huynh H....Mustelin T. (2004)
|
External Searches for NSF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NSF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NSF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NSF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NSF | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NSF gene:
Search GeneIP for patents involving NSF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NSF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NSF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NSF | | | OriGene Protein Over-expression Lysate for NSF | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NSF | | OriGene 3'-UTR Clone for NSF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NSF | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NSF | | OriGene Custom Protein Services for NSF | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NSF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NSF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NSF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NSF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSF |
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| | Antibodies & Assays for NSF |
| | | | Search Tocris compounds for NSF |
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 | | | NSF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSF |
|  |  |  | | | | ThermoFisher Antibody for NSF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSF |
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