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Aliases for NSA2 Gene

Aliases for NSA2 Gene

  • NSA2 Ribosome Biogenesis Homolog 2 3
  • Hairy Cell Leukemia Protein 1 2 3 4
  • TGF Beta-Inducible Nuclear Protein 1 2 3
  • TGF-Beta-Inducible Nuclear Protein 1 3 4
  • TINP1 3 4
  • NSA2 Ribosome Biogenesis Homolog (S. Cerevisiae) 2
  • TGF-Beta Inducible Nuclear Protein 3
  • HUSSY-29 3
  • HUSSY29 3
  • CDK105 3
  • HCL-G1 3
  • HCLG1 3

External Ids for NSA2 Gene

Previous GeneCards Identifiers for NSA2 Gene

  • GC05P074099
  • GC05P074062
  • GC05P069268

Summaries for NSA2 Gene

Entrez Gene Summary for NSA2 Gene

  • This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

GeneCards Summary for NSA2 Gene

NSA2 (NSA2 Ribosome Biogenesis Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for NSA2 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).

Gene Wiki entry for NSA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSA2 Gene

Genomics for NSA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NSA2 Gene

Chromosome:
5
Start:
74,765,429 bp from pter
End:
74,780,113 bp from pter
Size:
14,685 bases
Orientation:
Plus strand

Genomic View for NSA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSA2 Gene

No data available for Regulatory Elements for NSA2 Gene

Proteins for NSA2 Gene

  • Protein details for NSA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95478-NSA2_HUMAN
    Recommended name:
    Ribosome biogenesis protein NSA2 homolog
    Protein Accession:
    O95478

    Protein attributes for NSA2 Gene

    Size:
    260 amino acids
    Molecular mass:
    30065 Da
    Quaternary structure:
    • Component of the pre-66S ribosomal particle.

neXtProt entry for NSA2 Gene

Proteomics data for NSA2 Gene at MOPED

Post-translational modifications for NSA2 Gene

  • Ubiquitination at Lys 189 and Lys 201
  • Modification sites at PhosphoSitePlus

Other Protein References for NSA2 Gene

No data available for DME Specific Peptides for NSA2 Gene

Domains & Families for NSA2 Gene

Protein Domains for NSA2 Gene

Suggested Antigen Peptide Sequences for NSA2 Gene

Graphical View of Domain Structure for InterPro Entry

O95478

UniProtKB/Swiss-Prot:

NSA2_HUMAN :
  • Belongs to the ribosomal protein S8e family.
Family:
  • Belongs to the ribosomal protein S8e family.
genes like me logo Genes that share domains with NSA2: view

No data available for Gene Families for NSA2 Gene

Function for NSA2 Gene

Molecular function for NSA2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).

Gene Ontology (GO) - Molecular Function for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NSA2: view
genes like me logo Genes that share phenotypes with NSA2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NSA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NSA2 Gene

Localization for NSA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSA2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NSA2 Gene COMPARTMENTS Subcellular localization image for NSA2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with NSA2: view

Pathways & Interactions for NSA2 Gene

SuperPathways for NSA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with NSA2: view

No data available for Pathways by source and SIGNOR curated interactions for NSA2 Gene

Drugs & Compounds for NSA2 Gene

No Compound Related Data Available

Transcripts for NSA2 Gene

Unigene Clusters for NSA2 Gene

NSA2 ribosome biogenesis homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NSA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - -
SP2:
SP3:
SP4: - - - -

Relevant External Links for NSA2 Gene

GeneLoc Exon Structure for
NSA2
ECgene alternative splicing isoforms for
NSA2

Expression for NSA2 Gene

mRNA expression in normal human tissues for NSA2 Gene

Protein differential expression in normal tissues from HIPED for NSA2 Gene

This gene is overexpressed in Lung (35.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NSA2 Gene



SOURCE GeneReport for Unigene cluster for NSA2 Gene Hs.482526

genes like me logo Genes that share expression patterns with NSA2: view

Protein tissue co-expression partners for NSA2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NSA2 Gene

Orthologs for NSA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NSA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NSA2 35
  • 93.33 (n)
  • 99.62 (a)
NSA2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NSA2 35
  • 92.69 (n)
  • 99.62 (a)
NSA2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nsa2 35
  • 88.08 (n)
  • 99.23 (a)
Nsa2 16
Nsa2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NSA2 35
  • 99.87 (n)
  • 100 (a)
NSA2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nsa2 35
  • 88.59 (n)
  • 99.23 (a)
oppossum
(Monodelphis domestica)
Mammalia NSA2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NSA2 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves NSA2 35
  • 83.21 (n)
  • 96.54 (a)
NSA2 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NSA2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nsa2 35
  • 82.82 (n)
  • 97.69 (a)
Str.79 35
zebrafish
(Danio rerio)
Actinopterygii nsa2 35
  • 76.41 (n)
  • 94.62 (a)
wufb34b10 35
nsa2 36
  • 95 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.360 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008001 35
  • 64.99 (n)
  • 75.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ip259 35
  • 66.8 (n)
  • 75.29 (a)
Ip259 36
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_W09C5.1 35
  • 68.22 (n)
  • 70.93 (a)
W09C5.1 36
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL050W 35
  • 57.44 (n)
  • 63.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13619g 35
  • 62.56 (n)
  • 63.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSA2 35
  • 61.41 (n)
  • 62.31 (a)
NSA2 36
  • 62 (a)
OneToOne
NSA2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06360 35
  • 65.9 (n)
  • 72.31 (a)
soybean
(Glycine max)
eudicotyledons Gma.7693 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10191 35
barley
(Hordeum vulgare)
Liliopsida Hv.499 35
rice
(Oryza sativa)
Liliopsida Os.10094 35
Os07g0673100 35
  • 66.54 (n)
  • 70.27 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14408 35
corn
(Zea mays)
Liliopsida Zm.3343 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.406 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00981 35
  • 58.46 (n)
  • 63.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCP1E11.08 35
  • 63.97 (n)
  • 68.08 (a)
Species with no ortholog for NSA2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NSA2 Gene

ENSEMBL:
Gene Tree for NSA2 (if available)
TreeFam:
Gene Tree for NSA2 (if available)

Paralogs for NSA2 Gene

(1) SIMAP similar genes for NSA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NSA2: view

No data available for Paralogs for NSA2 Gene

Variants for NSA2 Gene

Sequence variations from dbSNP and Humsavar for NSA2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_051862 -

Variation tolerance for NSA2 Gene

Residual Variation Intolerance Score: 45.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NSA2 Gene

HapMap Linkage Disequilibrium report
NSA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NSA2 Gene

Disorders for NSA2 Gene

Relevant External Links for NSA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NSA2
genes like me logo Genes that share disorders with NSA2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSA2 Gene

Publications for NSA2 Gene

  1. TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. (PMID: 20129061) Watanabe Y. … Kato M. (Mol. Cell 2010) 23 67
  2. Fibroblasts from non-healing human chronic wounds show decreased expression of beta ig-h3, a TGF-beta inducible protein. (PMID: 18078741) Cha J. … Falanga V. (J. Dermatol. Sci. 2008) 23 67
  3. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 2 67
  4. Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates. (PMID: 10486207) Wu X. … Einhorn S. (Genomics 1999) 2 67
  5. Structural and functional characterization of the human perlecan gene promoter. Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element. (PMID: 9030592) Iozzo R.V. … Mauviel A. (J. Biol. Chem. 1997) 23 67

Products for NSA2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NSA2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for NSA2
  • Block miRNA regulation of NSA2 using miScript Target Protectors

Sources for NSA2 Gene

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