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Aliases for NSA2 Gene

Aliases for NSA2 Gene

  • NSA2 Ribosome Biogenesis Homolog (S. Cerevisiae) 2 3
  • Hairy Cell Leukemia Protein 1 2 3 4
  • TINP1 3 4 6
  • TGF Beta-Inducible Nuclear Protein 1 2 3
  • TGF-Beta-Inducible Nuclear Protein 1 3 4
  • HUSSY29 3 6
  • Ribosome Biogenesis Protein NSA2 Homolog 3
  • TGF-Beta Inducible Nuclear Protein 3
  • HUSSY-29 3
  • CDK105 3
  • HCL-G1 3
  • HCLG1 3

External Ids for NSA2 Gene

Previous GeneCards Identifiers for NSA2 Gene

  • GC05P074099
  • GC05P074062
  • GC05P069268

Summaries for NSA2 Gene

Entrez Gene Summary for NSA2 Gene

  • This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

GeneCards Summary for NSA2 Gene

NSA2 (NSA2 Ribosome Biogenesis Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with NSA2 include leukemia.

UniProtKB/Swiss-Prot for NSA2 Gene

  • Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).

Gene Wiki entry for NSA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSA2 Gene

Genomics for NSA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NSA2 Gene

Start:
74,766,991 bp from pter
End:
74,780,113 bp from pter
Size:
13,123 bases
Orientation:
Plus strand

Genomic View for NSA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSA2 Gene

No data available for Regulatory Elements for NSA2 Gene

Proteins for NSA2 Gene

  • Protein details for NSA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95478-NSA2_HUMAN
    Recommended name:
    Ribosome biogenesis protein NSA2 homolog
    Protein Accession:
    O95478
    Secondary Accessions:

    Protein attributes for NSA2 Gene

    Size:
    260 amino acids
    Molecular mass:
    30065 Da
    Quaternary structure:
    • Component of the pre-66S ribosomal particle.

neXtProt entry for NSA2 Gene

Proteomics data for NSA2 Gene at MOPED

Post-translational modifications for NSA2 Gene

  • Ubiquitination at Lys189 and Lys201
  • Modification sites at PhosphoSitePlus

Other Protein References for NSA2 Gene

No data available for DME Specific Peptides for NSA2 Gene

Domains for NSA2 Gene

Protein Domains for NSA2 Gene

Suggested Antigen Peptide Sequences for NSA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95478

UniProtKB/Swiss-Prot:

NSA2_HUMAN :
  • O95478
Family:
  • Belongs to the ribosomal protein S8e family.
genes like me logo Genes that share domains with NSA2: view

No data available for Gene Families for NSA2 Gene

Function for NSA2 Gene

Molecular function for NSA2 Gene

UniProtKB/Swiss-Prot Function: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).

Gene Ontology (GO) - Molecular Function for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NSA2: view
genes like me logo Genes that share phenotypes with NSA2: view

Animal Model Products

CRISPR Products

miRNA for NSA2 Gene

miRTarBase miRNAs that target NSA2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NSA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NSA2 Gene

Localization for NSA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSA2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NSA2 Gene COMPARTMENTS Subcellular localization image for NSA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with NSA2: view

Pathways for NSA2 Gene

SuperPathways for NSA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with NSA2: view

No data available for Pathways by source for NSA2 Gene

Transcripts for NSA2 Gene

Unigene Clusters for NSA2 Gene

NSA2 ribosome biogenesis homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NSA2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSA2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - -
SP2:
SP3:
SP4: - - - -

Relevant External Links for NSA2 Gene

GeneLoc Exon Structure for
NSA2
ECgene alternative splicing isoforms for
NSA2

Expression for NSA2 Gene

mRNA expression in normal human tissues for NSA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NSA2 Gene

SOURCE GeneReport for Unigene cluster for NSA2 Gene Hs.482526

genes like me logo Genes that share expressions with NSA2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NSA2 Gene

Orthologs for NSA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NSA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NSA2 35
  • 99.87 (n)
  • 100 (a)
NSA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NSA2 35
  • 93.33 (n)
  • 99.62 (a)
NSA2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NSA2 35
  • 92.69 (n)
  • 99.62 (a)
NSA2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nsa2 35
  • 88.08 (n)
  • 99.23 (a)
Nsa2 16
Nsa2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NSA2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NSA2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nsa2 35
  • 88.59 (n)
  • 99.23 (a)
chicken
(Gallus gallus)
Aves NSA2 35
  • 83.21 (n)
  • 96.54 (a)
NSA2 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NSA2 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nsa2 35
  • 82.82 (n)
  • 97.69 (a)
Str.79 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.360 35
zebrafish
(Danio rerio)
Actinopterygii nsa2 35
  • 76.41 (n)
  • 94.62 (a)
nsa2 36
  • 95 (a)
OneToOne
wufb34b10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008001 35
  • 64.99 (n)
  • 75.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ip259 35
  • 66.8 (n)
  • 75.29 (a)
Ip259 36
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_W09C5.1 35
  • 68.22 (n)
  • 70.93 (a)
W09C5.1 36
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL050W 35
  • 57.44 (n)
  • 63.85 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSA2 35
  • 61.41 (n)
  • 62.31 (a)
NSA2 36
  • 62 (a)
OneToOne
NSA2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13619g 35
  • 62.56 (n)
  • 63.46 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10191 35
soybean
(Glycine max)
eudicotyledons Gma.7693 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06360 35
  • 65.9 (n)
  • 72.31 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.499 35
corn
(Zea mays)
Liliopsida Zm.3343 35
rice
(Oryza sativa)
Liliopsida Os.10094 35
Os07g0673100 35
  • 66.54 (n)
  • 70.27 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14408 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00981 35
  • 58.46 (n)
  • 63.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCP1E11.08 35
  • 63.97 (n)
  • 68.08 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.406 35
Species with no ortholog for NSA2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NSA2 Gene

ENSEMBL:
Gene Tree for NSA2 (if available)
TreeFam:
Gene Tree for NSA2 (if available)

Paralogs for NSA2 Gene

Selected SIMAP similar genes for NSA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NSA2: view

No data available for Paralogs for NSA2 Gene

Variants for NSA2 Gene

Sequence variations from dbSNP and Humsavar for NSA2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1164694 -- 74,770,561(-) TGTTT(C/T)AGTTG intron-variant
rs2314938 -- 74,769,942(+) CAGAT(C/T)CATCT intron-variant
rs3932895 -- 74,770,128(-) GTCTT(C/G)AACTC intron-variant
rs3968877 -- 74,774,667(+) TTATA(A/G)CTAAG intron-variant
rs4596360 -- 74,771,567(+) GAAAa(A/G)ccggg intron-variant

Relevant External Links for NSA2 Gene

HapMap Linkage Disequilibrium report
NSA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NSA2 Gene

Disorders for NSA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NSA2 Gene including...

Search for NSA2 Gene in MalaCards »
genes like me logo Genes that share disorders with NSA2: view

No data available for UniProtKB/Swiss-Prot for NSA2 Gene

Publications for NSA2 Gene

  1. Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates. (PMID: 10486207) Wu X. … Einhorn S. (Genomics 1999) 2 3 4
  2. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 2 3 4
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 3

Products for NSA2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NSA2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for NSA2
  • Block miRNA regulation of NSA2 using miScript Target Protectors

Sources for NSA2 Gene

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