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NSA2 Gene

protein-coding   GIFtS: 50
GCID: GC05P074062

NSA2 Ribosome Biogenesis Homolog (S. Cerevisiae)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NSA2 Ribosome Biogenesis Homolog (S. Cerevisiae)1 2     CDK1052
Hairy Cell Leukemia Protein 11 2 3     HCL-G12
TINP12 3 5     HCLG12
TGF Beta-Inducible Nuclear Protein 11 2     Ribosome Biogenesis Protein NSA2 Homolog2
TGF-Beta-Inducible Nuclear Protein 12 3     TGF-Beta Inducible Nuclear Protein2
HUSSY292 5     

External Ids:    HGNC: 307281   Entrez Gene: 104122   Ensembl: ENSG000001643467   OMIM: 6124975   UniProtKB: O954783   

Export aliases for NSA2 gene to outside databases

Previous GC identifers: GC05P074099 GC05P069268


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NSA2 Gene:
This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was
identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a
pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at
elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several
related pseudogenes have been identified. (provided by RefSeq, Nov 2012)

GeneCards Summary for NSA2 Gene:
NSA2 (NSA2 ribosome biogenesis homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with NSA2 include t-cell leukemia, and hairy cell leukemia.

UniProtKB/Swiss-Prot: NSA2_HUMAN, O95478
Function: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of
pre-60S particles (By similarity)

Gene Wiki entry for NSA2 (TINP1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NSA2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNSA2 promoter sequence
   Search Chromatin IP Primers for NSA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NSA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.3   Ensembl cytogenetic band:  5q13.3   HGNC cytogenetic band: 5q13.3

NSA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NSA2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P074062:  view genomic region     (about GC identifiers)

Start:
74,062,817 bp from pter      End:
74,072,737 bp from pter
Size:
9,921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NSA2_HUMAN, O95478 (See protein sequence)
Recommended Name: Ribosome biogenesis protein NSA2 homolog  
Size: 260 amino acids; 30065 Da
Subunit: Component of the pre-66S ribosomal particle (By similarity)

Explore the universe of human proteins at neXtProt for NSA2: NX_O95478

Explore proteomics data for NSA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys189, Lys201
  • Modification sites at PhosphoSitePlus

  • See NSA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258594.1  NP_055701.1  

    ENSEMBL proteins: 
     ENSP00000296802   ENSP00000427266  

    NSA2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    Search for Antibodies for NSA2 at Abcam
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    ThermoFisher Antibody for NSA2
    LSBio Antibodies in human, mouse, rat for NSA2

    NSA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NSA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022309 Ribosomal_S8e/biogenesis_NSA2

    Graphical View of Domain Structure for InterPro Entry O95478

    ProtoNet protein and cluster: O95478

    1 Blocks protein domain: IPB001047 Ribosomal protein S8E

    UniProtKB/Swiss-Prot: NSA2_HUMAN, O95478
    Similarity: Belongs to the ribosomal protein S8e family


    NSA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NSA2_HUMAN, O95478
    Function: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of
    pre-60S particles (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044822poly(A) RNA binding IDA--
         
    NSA2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NSA2:
     Decreased TP53 protein express  G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NSA2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NSA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NSA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NSA2:
    hsa-let-7b-5p (MIRT032355), hsa-mir-155-5p (MIRT020758)

    Block miRNA regulation of human, mouse, rat NSA2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NSA2:
    hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidNSA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NSA2
    Predesigned siRNA for gene silencing in human, mouse, rat NSA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NSA2

    Clone
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    OriGene clones in human, mouse for NSA2 (see all 7)
    OriGene ORF clones in mouse, rat for NSA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NSA2 (NM_014886)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NSA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSA2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NSA2_HUMAN, O95478: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0030529ribonucleoprotein complex IEA--

    NSA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NSA2
    Interactions:

        Search GeneGlobe Interaction Network for NSA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NSA2 (O954783 ENSP000002968024) via UniProtKB, MINT, STRING, and/or I2D (see all 368)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--

    NSA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NSA2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NSA2 gene (2 alternative transcripts): 
    NM_001271665.1  NM_014886.4  

    Unigene Cluster for NSA2:

    NSA2 ribosome biogenesis homolog (S. cerevisiae)
    Hs.482526  [show with all ESTs]
    Unigene Representative Sequence: NR_073403
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296802(uc003kdk.1) ENST00000514918 ENST00000513356 ENST00000515524

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NSA2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NSA2:
    hsa-miR-33a*
    SwitchGear 3'UTR luciferase reporter plasmidNSA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NSA2
    Predesigned siRNA for gene silencing in human, mouse, rat NSA2
    Clone
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    OriGene clones in human, mouse for NSA2 (see all 7)
    OriGene ORF clones in mouse, rat for NSA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NSA2 (NM_014886)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NSA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSA2
    Primer
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    OriGene qPCR primer pairs and template standards for NSA2
    OriGene qSTAR qPCR primer pairs in human, mouse for NSA2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat NSA2
      QuantiTect SYBR Green Assays in human, mouse, rat NSA2
      QuantiFast Probe-based Assays in human, mouse, rat NSA2

    Additional mRNA sequence: 

    AF077615.1 AF372458.1 AJ012409.1 AK313784.1 AY443419.1 BC005288.1 NR_073403.1 

    18 DOTS entries:

    DT.97862484  DT.100059733  DT.100059726  DT.100059176  DT.120814492  DT.120814242  DT.121156010  DT.121211263 
    DT.120814363  DT.121287831  DT.120814469  DT.95092750  DT.95173442  DT.100776785  DT.102835948  DT.121156036 
    DT.92460306  DT.95173443 

    Selected AceView cDNA sequences (see all 320):

    W67521 AJ012409 BE731640 F00447 BM555957 BM840898 AA113244 CF127031 
    BU186367 AA773137 AA232252 AA309707 CA434370 T36011 AI636753 BM719740 
    BG673963 AA379078 AF372458 BM756424 BU164775 BX280345 AL709742 AA921837 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NSA2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:                                            -     -                     
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                            -     -     -     -         


    ECgene alternative splicing isoforms for NSA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NSA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCAATGA
    NSA2 Expression
    About this image

    NSA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NSA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482526
        Custom PCR Arrays for NSA2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NSA2 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nsa21 , 5 NSA2 ribosome biogenesis homolog (S. cerevisiae)1, 5 88.08(n)1
    99.23(a)1
      13 (50.66 cM)5
    590501  NM_021552.51  NP_067527.31 
     971294275 
    chicken
    (Gallus gallus)
    Aves NSA21 NSA2 ribosome biogenesis homolog (S. cerevisiae) 83.21(n)
    96.54(a)
      427206  NM_001006579.1  NP_001006579.1 
    lizard
    (Anolis carolinensis)
    Reptilia NSA26
    NSA2 ribosome biogenesis homolog (S. cerevisiae)
    98(a)
    1 ↔ 1
    2(15114798-15127059)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.792 Transcribed sequence with strong similarity to protein more 82.41(n)    BX732825.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb34b102 wufb34b10 76.28(n)   321769  BC046083.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ip2591 Intronic Protein 259 66.8(n)
    75.29(a)
      34419  NM_001273418.1  NP_001260347.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_W09C5.11 CELE_W09C5.1 68.22(n)
    70.93(a)
      173232  NM_060986.3  NP_493387.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NSA2(YER126C)4
    NSA21
    Protein constituent of 66S pre-ribosomal particles, more4
    NSA21
    61.41(n)1
    62.31(a)1
      5(414179-413394)4
    8568631, 4  NP_011052.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G063601 AT5G06360 65.9(n)
    72.31(a)
      830524  NM_120719.3  NP_196254.1 
    rice
    (Oryza sativa)
    Liliopsida Os.100942 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.62(n)    AK060100.1 


    ENSEMBL Gene Tree for NSA2 (if available)
    TreeFam Gene Tree for NSA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NSA2 gene
    1 SIMAP similar gene for NSA2 using alignment to 2 protein entries:     NSA2_HUMAN (see all proteins):
    CDK105

    NSA2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for NSA2 (see all 9)
    PGOHUM00000242316 PGOHUM00000239548 PGOHUM00000246804 PGOHUM00000244395 PGOHUM00000240420


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NSA2 (see all 181)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391651081,2
    C--74065074(+) ACAAAA/TGAATG 5 K M mis11Minor allele frequency- T:0.00NA 4288
    rs2017835541,2
    --74065147(+) GCTAAA/CGTACT 5 K N mis10--------
    rs346549491,2
    C--74065177(+) AAAAGA/GAAAGA 5 R syn12Minor allele frequency- G:0.02NA WA 196
    rs2008928701,2
    --74065189(+) AAGGCA/GGTAAG 5 A syn10--------
    rs2013345421,2
    --74065410(+) TGAAA-/TTAAAA 3 -- int10--------
    rs1891690671,2
    --74065688(+) TATTTC/TAGTTT 3 -- int10--------
    rs23149381,2
    C,F,H--74065767(+) CAGATC/TCATCT 3 -- int16Minor allele frequency- T:0.06NS EA WA 538
    rs68820351,2
    C,F,A,H--74065821(+) CCAGTA/GTTATG 3 -- int111Minor allele frequency- G:0.13NS EA NA CSA WA 892
    rs1440858681,2
    C--74065848(+) AACACA/GTATAC 3 -- int10--------
    rs39328951,2
    C,A--74065953(-) GTCTTC/GAACTC 3 -- int10--------

    HapMap Linkage Disequilibrium report for NSA2 (74062817 - 74072737 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NSA2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NSA2
    DNA2.0 Custom Variant and Variant Library Synthesis for NSA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612497    OMIM disorders: --

    5 diseases for NSA2:    About MalaCards
    t-cell leukemia    hairy cell leukemia    diabetic nephropathy    leukemia
    malaria


    NSA2 for disorders           About GeneDecksing


    Export disorders for NSA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NSA2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with NSA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2, 3 Stanchi F.... Valle G. (Yeast 2001)
    2. Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates. (PubMed id 10486207)1, 2, 3 Wu X.... Einhorn S. (Genomics 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    5. Nop-7-associated 2 (NSA2), a candidate gene for diabetic nephropathy, is involved in the TGFI^1 pathway. (PubMed id 23220173)1 Shahni R....Malik A.N. (amp 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Elevated levels of renal and circulating Nop-7-associated 2 (NSA2) in rat and mouse models of diabetes, in mesangial cells in vitro and in patients with diabetic nephropathy. (PubMed id 22095236)1 Shahni R....Malik A.N. (Diabetologia 2012)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10412 HGNC: 30728 AceView: TINP1 Ensembl:ENSG00000164346 euGenes: HUgn10412
    ECgene: NSA2 H-InvDB: NSA2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NSA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NSA2 gene:
    Search GeneIP for patents involving NSA2

    GeneCards and IP:
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