Aliases for NRXN3 Gene
External Ids for NRXN3 Gene
Previous HGNC Symbols for NRXN3 Gene
Previous GeneCards Identifiers for NRXN3 Gene
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]
GeneCards Summary for NRXN3 Gene
NRXN3 (Neurexin 3) is a Protein Coding gene. Diseases associated with NRXN3 include Autism Spectrum Disorder and Alcohol Dependence. Among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Cell adhesion molecules (CAMs). GO annotations related to this gene include receptor activity and cell adhesion molecule binding. An important paralog of this gene is CNTNAP1.
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity).