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Aliases for NRXN2 Gene

Aliases for NRXN2 Gene

  • Neurexin 2 2 3 5
  • Neurexin II-Alpha 4
  • Neurexin II-Beta 4
  • Neurexin-2-Alpha 4
  • Neurexin II 2
  • KIAA0921 4

External Ids for NRXN2 Gene

Previous GeneCards Identifiers for NRXN2 Gene

  • GC11M066889
  • GC11M066055
  • GC11M064150
  • GC11M064151
  • GC11M064130
  • GC11M064373
  • GC11M060700

Summaries for NRXN2 Gene

Entrez Gene Summary for NRXN2 Gene

  • This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]

GeneCards Summary for NRXN2 Gene

NRXN2 (Neurexin 2) is a Protein Coding gene. Diseases associated with NRXN2 include spinal cord glioma and spinal cancer. Among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex and Cell adhesion molecules (CAMs). GO annotations related to this gene include transmembrane signaling receptor activity and calcium channel regulator activity. An important paralog of this gene is CNTNAP1.

UniProtKB/Swiss-Prot for NRXN2 Gene

  • Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

  • Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

Gene Wiki entry for NRXN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRXN2 Gene

Genomics for NRXN2 Gene

Regulatory Elements for NRXN2 Gene

Promoters for NRXN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRXN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRXN2 Gene

Chromosome:
11
Start:
64,606,174 bp from pter
End:
64,723,188 bp from pter
Size:
117,015 bases
Orientation:
Minus strand

Genomic View for NRXN2 Gene

Genes around NRXN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRXN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRXN2 Gene

Proteins for NRXN2 Gene

  • Protein details for NRXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58401-NRX2B_HUMAN
    Recommended name:
    Neurexin-2-beta
    Protein Accession:
    P58401

    Protein attributes for NRXN2 Gene

    Size:
    666 amino acids
    Molecular mass:
    70927 Da
    Quaternary structure:
    • The cytoplasmic C-terminal region binds to CASK. Specific isoforms bind alpha-dystroglycan and neuroligins NLGN1, NLGN2 and NLGN3 (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NRXN2 Gene

    Alternative splice isoforms for NRXN2 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for NRXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2S2-NRX2A_HUMAN
    Recommended name:
    Neurexin-2
    Protein Accession:
    Q9P2S2
    Secondary Accessions:
    • A7E2C1
    • Q9Y2D6

    Protein attributes for NRXN2 Gene

    Size:
    1712 amino acids
    Molecular mass:
    184982 Da
    Quaternary structure:
    • The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. Interacts with INADL (By similarity). Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).
    SequenceCaution:
    • Sequence=BAA76765.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NRXN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRXN2 Gene

Proteomics data for NRXN2 Gene at MOPED

Post-translational modifications for NRXN2 Gene

  • Glycosylation at Asn 190
  • Glycosylation at Asn 60, Asn 338, Asn 841, and Asn 1236
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRXN2 Gene

Domains & Families for NRXN2 Gene

Suggested Antigen Peptide Sequences for NRXN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2S2

UniProtKB/Swiss-Prot:

NRX2A_HUMAN :
  • Contains 3 EGF-like domains.
  • Belongs to the neurexin family.
Domain:
  • Contains 3 EGF-like domains.
  • Contains 6 laminin G-like domains.
  • Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan.
  • Contains 1 laminin G-like domain.
Family:
  • Belongs to the neurexin family.
genes like me logo Genes that share domains with NRXN2: view

No data available for Gene Families for NRXN2 Gene

Function for NRXN2 Gene

Molecular function for NRXN2 Gene

GENATLAS Biochemistry:
rat neurexin II alpha homolog longer form,also coding for the shorter beta neurexin II form,both with multiple alternatively spliced isoforms,potentially involved in neuronal cell adhesion and intercellular signaling
UniProtKB/Swiss-Prot Function:
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
UniProtKB/Swiss-Prot Function:
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.

Gene Ontology (GO) - Molecular Function for NRXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050839 cell adhesion molecule binding ISS,TAS 18923512
genes like me logo Genes that share ontologies with NRXN2: view
genes like me logo Genes that share phenotypes with NRXN2: view

Animal Models for NRXN2 Gene

MGI Knock Outs for NRXN2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NRXN2 Gene

Localization for NRXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRXN2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRXN2 Gene COMPARTMENTS Subcellular localization image for NRXN2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NRXN2 Gene

Pathways & Interactions for NRXN2 Gene

genes like me logo Genes that share pathways with NRXN2: view

Pathways by source for NRXN2 Gene

1 KEGG pathway for NRXN2 Gene

Interacting Proteins for NRXN2 Gene

Gene Ontology (GO) - Biological Process for NRXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007158 neuron cell-cell adhesion TAS 18923512
GO:0007269 neurotransmitter secretion IEA,ISS --
GO:0030534 adult behavior IMP 21424692
GO:0071625 vocalization behavior IMP 21424692
GO:0097104 postsynaptic membrane assembly ISS --
genes like me logo Genes that share ontologies with NRXN2: view

No data available for SIGNOR curated interactions for NRXN2 Gene

Drugs & Compounds for NRXN2 Gene

No Compound Related Data Available

Transcripts for NRXN2 Gene

Unigene Clusters for NRXN2 Gene

Neurexin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRXN2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - - - -
SP2: -
SP3:
SP4:
SP5:
SP6: -
SP7: -
SP8:
SP9: -
SP10:

ExUns: 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25
SP1: -
SP2:
SP3: - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for NRXN2 Gene

GeneLoc Exon Structure for
NRXN2
ECgene alternative splicing isoforms for
NRXN2

Expression for NRXN2 Gene

mRNA expression in normal human tissues for NRXN2 Gene

mRNA differential expression in normal tissues according to GTEx for NRXN2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.0) and Brain - Cerebellum (x7.8).

Protein differential expression in normal tissues from HIPED for NRXN2 Gene

This gene is overexpressed in Fetal Brain (31.9), Cerebrospinal fluid (13.4), and Plasma (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRXN2 Gene



SOURCE GeneReport for Unigene cluster for NRXN2 Gene Hs.372938

mRNA Expression by UniProt/SwissProt for NRXN2 Gene

P58401-NRX2B_HUMAN
Tissue specificity: Predominantly expressed in brain.
genes like me logo Genes that share expression patterns with NRXN2: view

Protein tissue co-expression partners for NRXN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NRXN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRXN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRXN2 35
  • 99.75 (n)
  • 99.82 (a)
NRXN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRXN2 35
  • 94.43 (n)
  • 98.87 (a)
NRXN2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRXN2 36
  • 98 (a)
OneToOne
NRXN2 35
  • 95.01 (n)
  • 98.93 (a)
mouse
(Mus musculus)
Mammalia Nrxn2 16
Nrxn2 35
  • 92.37 (n)
  • 98.3 (a)
Nrxn2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRXN2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRXN2 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrxn2 35
  • 92.7 (n)
  • 97.96 (a)
chicken
(Gallus gallus)
Aves NRXN3 36
  • 67 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NRXN2 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrxn2 35
  • 68.15 (n)
  • 75.64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9177 35
zebrafish
(Danio rerio)
Actinopterygii NRXN2 (2 of 2) 36
  • 78 (a)
OneToMany
nrxn2a 36
  • 73 (a)
OneToMany
nrxn2b 35
  • 74.84 (n)
  • 76.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nrx-1 37
  • 34 (a)
Nrx-1 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C29A12.4 37
  • 25 (a)
nrx-1 36
  • 25 (a)
OneToMany
Species with no ortholog for NRXN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRXN2 Gene

ENSEMBL:
Gene Tree for NRXN2 (if available)
TreeFam:
Gene Tree for NRXN2 (if available)

Paralogs for NRXN2 Gene

Paralogs for NRXN2 Gene

(4) SIMAP similar genes for NRXN2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NRXN2: view

Variants for NRXN2 Gene

Sequence variations from dbSNP and Humsavar for NRXN2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12273892 - 64,713,458(+) CCAGC(A/T)GCAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs80841 -- 64,670,018(+) GTCCA(C/T)GGTCT intron-variant
rs475406 -- 64,684,850(+) AGCAT(C/G)TGGGA intron-variant, upstream-variant-2KB
rs475642 -- 64,657,219(+) GCAAG(A/C)AATGG intron-variant
rs518053 -- 64,688,627(+) CCCAG(C/T)AGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRXN2 Gene

Variant ID Type Subtype PubMed ID
nsv897692 CNV Loss 21882294
nsv897693 CNV Loss 21882294
esv2422214 CNV Deletion 17116639
nsv832188 CNV Gain 17160897
nsv897694 CNV Loss 21882294
nsv818842 CNV Gain 17921354
nsv528506 CNV Loss 19592680
dgv1171n71 CNV Loss 21882294
nsv897696 CNV Loss 21882294
esv2676104 CNV Deletion 23128226
esv28928 CNV Gain 19812545
dgv1172n71 CNV Loss 21882294
esv2516770 CNV Insertion 19546169
esv1090895 CNV Insertion 17803354
nsv359 CNV Loss 18451855
dgv153n27 CNV Loss 19166990
nsv832189 CNV Loss 17160897

Variation tolerance for NRXN2 Gene

Residual Variation Intolerance Score: 0.657% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.78; 78.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRXN2 Gene

HapMap Linkage Disequilibrium report
NRXN2
Human Gene Mutation Database (HGMD)
NRXN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRXN2 Gene

Disorders for NRXN2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NRXN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinal cord glioma
  • glial neoplasm spinal cord
spinal cancer
  • intraspinal tumor
pancreatic gastrinoma
  • pancreatic g-cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search NRXN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRXN2

Genetic Association Database (GAD)
NRXN2
Human Genome Epidemiology (HuGE) Navigator
NRXN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRXN2
genes like me logo Genes that share disorders with NRXN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRXN2 Gene

Publications for NRXN2 Gene

  1. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48 67
  2. Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. (PMID: 11944992) Rowen L. … Graveley B.R. (Genomics 2002) 3 23
  3. Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. (PMID: 1621094) Ushkaryov Y.A. … SA1dhof T.C. (Science 1992) 2 3
  4. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3
  5. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PMID: 22797727) Okada Y. … Tanaka T. (Nat. Genet. 2012) 3

Products for NRXN2 Gene

Sources for NRXN2 Gene

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