NRXN2 Gene
protein-coding GIFtS: 61
GCID: GC11M064373
|
|
neurexin 2
| |
Aliases
for NRXN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neurexin 21 2 | | Neurexin-2-Alpha1 | | Neurexin II2 | | Neurexin II-Alpha3 | | Neurexin-2-Beta1 | | Neurexin II-Beta3 | | KIAA09213 | | |
Export aliases for NRXN2 gene to outside databasesPrevious GC identifers: GC11M066889 GC11M066055 GC11M064623 GC11M064150 GC11M064151 GC11M064130 GC11M060700 |
Summaries
for NRXN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NRXN2:
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion moleculesand receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts areproduced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts areproduced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growthfactor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. Thebeta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicingand the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID:11944992).(provided by RefSeq, Jun 2010)
UniProtKB/ace: NRX2A_HUMAN, Q9P2S2 (see all)Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion
Gene Wiki entry for NRXN2
|
Genomic Views
for NRXN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NRXN2 gene promoter:
E2F-3a E2F-4 E2F E2F-1 Bach2 E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NRXN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRXN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13NRXN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M064373: view genomic region
(about GC identifiers)
Start:
|
64,373,646 bp from pter |
End:
|
64,490,660 bp from pter |
Size:
|
117,015 bases |
Orientation:
|
minus strand |
|
Proteins
for NRXN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NRX2A_HUMAN, Q9P2S2 (See
protein sequence)Recommended Name: Neurexin-2 precursor Size: 1712 amino acids; 184982 Da
Subunit: The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan. Interacts with INADL(By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=BAA76765.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E2C1 Q9Y2D6Alternative promoter usage, Alternative splicing: 3 isoforms: Q9P2S2-1 Q9P2S2-2 P58401-1 UniProtKB/Swiss-Prot: NRX2B_HUMAN, P58401 (See
protein sequence) Recommended Name: Neurexin-2-beta precursor Size: 666 amino acids; 70927 Da
Subunit: The cytoplasmic C-terminal region binds to CASK. Specific isoforms bind alpha-dystroglycan and neuroliginsNLGN1, NLGN2 and NLGN3 (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)Alternative promoter usage, Alternative splicing: 3 isoforms: P58401-1 Q9P2S2-1 Q9P2S2-2 Explore the universe of human proteins at neXtProt for NRXN2: NX_P58401
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P58401
NRXN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_055895.1 NP_620060.1 NP_620063.1
ENSEMBL proteins: ENSP00000301894 ENSP00000366774 ENSP00000366782 ENSP00000386416 ENSP00000407374 ENSP00000388971 ENSP00000411271 ENSP00000412211 ENSP00000265459
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
NRXN2 for ontologies About GeneDecksing
NRXN2 Antibody Products:
Assay Products for NRXN2: |
Protein
Domains /
Families
for NRXN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NRXN2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9P2S2Graphical View of Domain Structure for InterPro Entry P58401ProtoNet protein and cluster: Q9P2S2 3 Blocks protein families: IPB001791 Laminin G IPB003585 Neurexin/syndecan/glycophorin C IPB006210 Type I EGF
UniProtKB/Swiss-Prot: NRX2A_HUMAN, Q9P2S2Similarity: Belongs to the neurexin familySimilarity: Contains 3 EGF-like domainsSimilarity: Contains 6 laminin G-like domainsUniProtKB/Swiss-Prot: NRX2B_HUMAN, P58401Domain: Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycanSimilarity: Belongs to the neurexin familySimilarity: Contains 1 laminin G-like domain |
Function
for NRXN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/ace: NRX2A_HUMAN, Q9P2S2 (see all)Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion Genatlas biochemistry entry for NRXN2:rat neurexin II alpha homolog longer form,also coding for the shorter beta neurexin II form,both with multiplealternatively spliced isoforms,potentially involved in neuronal cell adhesion and intercellular signaling
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRXN2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRXN2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): NRXN2 (NM_015080) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRXN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRXN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRXN2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
NRXN2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for NRXN2: Nrxn2tm1Sud Nrxn2tm3Sud
5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Nrxn2):
NRXN2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NRXN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion molecules (CAMs) | | | 2 | Muscular Dystrophies and Dystrophin-Glycoprotein Complex | | | 3 | GABA A receptor activation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for NRXN2
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NRXN2
1 
Kegg Pathway (Kegg details for NRXN2):
NRXN2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRXN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/12 Interacting proteins for NRXN2 (P584012, 3 Q9P2S22, 3 ENSP000002654594) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
NRXN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NRXN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NRXN2
Search CenterWatch for drugs/clinical trials and news about NRXN2 / NRX2B
|
Transcripts
for NRXN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NRXN2 gene (3 alternative transcripts): NM_015080.3 NM_138732.2 NM_138734.2 Unigene Cluster for NRXN2: Neurexin 2 Hs.372938 [show with all ESTs]Unigene Representative Sequence: NM_01508016 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000464307(uc001oao.3) ENST00000301894(uc001oap.3) ENST00000377551(uc001oaq.3)
ENST00000377559(uc021qkx.1 uc001oas.3) ENST00000409571 ENST00000475737
ENST00000423049 ENST00000467055 ENST00000487484 ENST00000486057 ENST00000496291
ENST00000442300 ENST00000417749 ENST00000437746 ENST00000466324 ENST00000265459(uc021qkw.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRXN2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRXN2 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NRXN2 (NM_015080) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRXN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRXN2 |
Additional cDNA sequence: AB023138.2 AB035266.1 AB177862.1 AK098211.1 BC150275.1 14 DOTS entries: DT.120739869 DT.95263591 DT.202749 DT.97770775 DT.97820132 DT.101980234 DT.120739881 DT.97836354 DT.95155313 DT.95263587 DT.120739850 DT.120739856 DT.75179725 DT.91983894 24/26 AceView cDNA sequences (see all 26): BF946851 BF946729 CA415696 BM714703 BF946835 BF946858 BF922840 BF946751 BF946731 BF946700 BF946849 AB023138 BF948522 NM_138732 NM_015080 BG911023 CB152238 BQ339204 BQ339200 BF528907 BF948523 BG912141 AA663739 BF946831
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NRXN2 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | |
ECgene alternative splicing isoforms for NRXN2
|
Expression
for NRXN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NRXN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAAGTACC
About this image
See NRXN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NRXN2
SOURCE GeneReport for Unigene cluster: Hs.372938
UniProtKB/Swiss-Prot: NRX2A_HUMAN, Q9P2S2Tissue specificity: Predominantly expressed in brain
SABiosciences Custom PCR Arrays for NRXN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRXN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NRXN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRXN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRXN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRXN2 |
Orthologs
for NRXN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NRXN2 gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
NRXN26-- |
-- |
88(a)67(a) |
1 ↔ 1possible ortholog |
GL343652.1(177895-205524) 1(260499662-260910393) |
zebrafish
(Danio rerio) |
Actinopterygii |
nrxn2b1 |
neurexin 2b |
74.46(n)
76.25(a) |
|
560420 NM_001079984.1 NP_001073453.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Nrx-13 |
-- |
34(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
C29A12.43 |
neurexin I like |
25(a) |
|
V(10827618-10849015) -- |
ENSEMBL Gene Tree for NRXN2 (if available)
TreeFam Gene Tree for NRXN2 (if available) |
Paralogs
for NRXN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NRXN2 gene
- CNTNAP12 NRXN32 CNTNAP52 CNTNAP3B2 LOC6437922 CNTNAP32 CNTNAP22 CNTNAP42
- NRXN12
4 SIMAP similar genes for NRXN2 using alignment to 7 protein entries: NRX2A_HUMAN (see all proteins):KIAA0921 DKFZp313P2036 NRXN3 NRXN1
NRXN2 for paralogs About GeneDecksing
|
Genomic Variants
for NRXN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NRXN2 (64373646 - 64490660 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for NRXN2
6 CNVs: 4753 53146 9667 4752 5422 71341
1 Indel: 101240
Human Gene Mutation Database (HGMD): NRXN2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRXN2 |
|
Disorders
/ Diseases
for NRXN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NRXN2 for disorders About GeneDecksing
OMIM gene information: 600566
OMIM disorders: --
11  diseases for NRXN2: About MalaCardspancreatic gastrinoma sporadic breast cancer gastrinoma breast cancer
prostate cancer prostatitis schizophrenia pancreatitis
neuronitis muscular dystrophy gout
3 diseases from the University of Copenhagen DISEASES database for NRXN2:Pancreatic gastrinoma Spinal cancer Autistic disorder Human Genome Epidemiology (HuGE) Navigator: NRXN2 (4 documents)
Export disorders for NRXN2 gene to outside databases
|
Publications
for NRXN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NRXN2 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with NRXN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. (PubMed id 1621094)1, 3 Ushkaryov Y.A....Sudhof T.C. (1992)
- Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity. (PubMed id 11944992)1, 9 Rowen L.... Graveley B.R. (2002)
- Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Truncating mutations in NRXN2 and NRXN1 in autism spe ctrum disorders and schizophrenia. (PubMed id 21424692)1 Gauthier J....Rouleau G.A. (2011)
- Genome-wide association study for serum urate concent rations and gout among African Americans identifies genomic risk loci and a nov el URAT1 loss-of-function allele. (PubMed id 21768215)1 Tin A....KAPttgen A. (2011)
- Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
- Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1 Vega A....Carracedo A. (2009)
- Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1 GratacA^s M....Carracedo A. (2008)
|
External Searches for NRXN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NRXN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NRXN2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NRXN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NRXN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NRXN2 gene:
Search GeneIP for patents involving NRXN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NRXN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NRXN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRXN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRXN2 | | | OriGene Protein Over-expression Lysate for NRXN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NRXN2 | | OriGene 3'-UTR Clone for NRXN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRXN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRXN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NRXN2 | | OriGene Custom Protein Services for NRXN2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NRXN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRXN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRXN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRXN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRXN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRXN2 |
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| | | | Search Tocris compounds for NRXN2 |
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 | | | NRXN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRXN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for NRXN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRXN2 |
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