External Ids for NRTN Gene
Previous GeneCards Identifiers for NRTN Gene
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016]
GeneCards Summary for NRTN Gene
NRTN (Neurturin) is a Protein Coding gene. Diseases associated with NRTN include Nrtn-Related Hirschsprung Disease and Hirschsprung Disease 1. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is ARTN.
UniProtKB/Swiss-Prot for NRTN Gene
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.