External Ids for NRTN Gene
Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for NRTN Gene
NRTN (Neurturin) is a Protein Coding gene. Diseases associated with NRTN include nrtn-related hirschsprung disease and constipation. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is PSPN.
UniProtKB/Swiss-Prot for NRTN Gene
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells