NRTN Gene

Aliases
for NRTN gene

Previous GC identifers: GC19P005916 GC19P005763 GC19P005583

Summaries
for NRTN gene

Genomic Views
for NRTN gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011255.14  

SwitchGear Promoter luciferase reporter plasmid: NRTN promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRTN

NRTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P005774:  view genomic region     (about GC identifiers)

Proteins
for NRTN gene

Explore the universe of human proteins at neXtProt for NRTN: NX_Q99748

NRTN Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for NRTN (Neurturin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: NRTN OriGene Custom Protein Services for NRTN
	GenScript Custom Purified and Recombinant Proteins Services for NRTN
	Novus Biologicals NRTN Protein Novus Biologicals NRTN Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NRTN

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NRTN
	R&D Systems Antibodies for NRTN (Neurturin)
	OriGene Antibodies (see all 3): NRTN OriGene Custom Antibody Services for NRTN
	GenScript Custom Superior Antibodies Services for NRTN
	Novus Biologicals NRTN Antibodies
	Search for Antibodies for NRTN at Abcam
	Uscn Antibodies for NRTN
	ThermoFisher Antibodies for NRTN

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NRTN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NRTN

Protein Domains /
Families
for NRTN gene

ProtoNet protein and cluster: Q99748

Function
for NRTN gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRTN
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NRTN (see all 10):
		hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
		SwitchGear 3'UTR luciferase reporter plasmid: NRTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRTN (see all 7) OriGene shRNA RFP: NRTN OriGene siRNA: NRTN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRTN

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NRTN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRTN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRTN OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NRTN (NM_004558)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRTN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NRTN
		Search LifeMap BioReagents cell lines for NRTN

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NRTN

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Nrtn)

Pathways & Interactions
for NRTN gene

	Super-pathway	contained gene-specific pathways
1	Development EGFR signaling pathway	Development GDNF family signaling 0.45 GDNF-Family Ligands and Receptor Interactions 0.21 Development_GDNF family signaling 0.45
2	NCAM signaling for neurite out-growth	NCAM signaling for neurite out-growth 1.00 NCAM1 interactions 0.62
3	Axon guidance	Axon guidance 1.00 Developmental Biology 0.69

1 EMD Millipore Pathway for NRTN

Development GDNF family signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NRTN

GDNF-Family Ligands and Receptor Interactions

1 GeneGo (Thomson Reuters) Pathway for NRTN

Development GDNF family signaling

4        Reactome Pathways for NRTN

	Developmental Biology
	NCAM1 interactions
	NCAM signaling for neurite out-growth
	Axon guidance

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for NRTN gene

Transcripts
for NRTN gene

Expression
for NRTN gene

NRTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATTATCGA

6 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LimbForelimb Muscle Satellite PoolForelimb Muscle Satellite Cells			Skeletal Muscle
	LimbHindlimb Muscle Satellite PoolHindlimb Muscle Satellite Cells			Skeletal Muscle
	Skeletal MuscleCervical Muscle Satellite PoolMuscle Satellite Cells			Skeletal Muscle
	Skeletal MuscleLumbar Muscle Satellite PoolMuscle Satellite Cells			Skeletal Muscle
	Skeletal MuscleSacral Muscle Satellite PoolMuscle Satellite Cells			Skeletal Muscle
	Skeletal MuscleThoracic Muscle Satellite PoolMuscle Satellite Cells			Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	mK3 (Cell line)			Kidney
	mK4 (Cell line)			Kidney
	Definitive endoderm-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NRTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRTN

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NRTN

Orthologs
for NRTN gene

Paralogs
for NRTN gene

Paralogs for NRTN gene

GDNF²  PSPN²  ARTN²  

2 SIMAP similar genes for NRTN using alignment to 1 protein entry:     NRTN_HUMAN:

GDNF    PSPN

NRTN for paralogs           About GeneDecksing

Genomic Variants
for NRTN gene

10/138 NCBI SNPs in NRTN are shown (see all 138)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs104116441,2	C,F,A,	--	5581933(+)	TCTCTT/AGTGGG	1	--	us2k1		1		WA	118
rs792030771,2	C,F,	--	5582090(+)	AGGCGC/TGGTCC	1	--	us2k1		1		WA	118
rs124616021,2	C,H,	--	5582449(+)	ACTCAC/GAGCAC	1	--	us2k1		2		NA EA	122
rs735543571,2	C,	--	5583420(+)	ATGTCC/TAGGGC	1	--	us2k1		3		WA CSA	121
rs1152876191,2	C,F,	--	5583808(+)	ATCGGC/TTCCTC	1	--	ut51		1		WA	118
rs735543591,2	C,F,	--	5583893(+)	TTCAAT/CGGTTC	1	--	ut51		5		WA CSA	126
rs1125150551,2	C,F	--	5584059(+)	TGCAGC/TGCTGG	2	R C	mis1		2		CSA NA	4444
rs75082121,2	C,	--	5584442(+)	ggaggA/Ttctct	1	--	int1		0	--	--	--	--
rs767605011,2	F,	--	5584822(+)	GTCCCG/ATGGGG	1	--	int1		1		EA	120
rs747262051,2		--	5585040(+)	AGAGAC/TGGGGC	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for NRTN (5823813 - 5828335 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NRTN: --
Human Gene Mutation Database (HGMD): NRTN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRTN

DNA2.0 Custom Variant and Variant Library Synthesis for NRTN

Disorders / Diseases
for NRTN gene

20/26 diseases for NRTN

10/11 Novoseek disease relationships for NRTN gene (see all 11)    About this table

Publications
for NRTN gene

PubMed articles for NRTN gene, integrated from 9 sources (see all 149): (articles sorted by number of sources associating them with NRTN)

Utopia: connect your pdf to the dynamic world of online information

1. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. (PubMed id 8945474)^{1, 2, 3, 9} Kotzbauer P.T.... Milbrandt J. (1996)
2. Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease. (PubMed id 9700200)^{1, 2, 9} Doray B.... Lyonnet S. (1998)
3. Expression patterns of the glial cell line-derived neurotrophic factor, neurturin, their cognate receptors GFRalpha-1, GFRalpha-2, and a common signal transduction element c-Ret in the human skin hair follicles. (PubMed id 18222320)^{1, 9} Adly M.A....Paus R. (2008)
4. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. (PubMed id 9192898)^{1, 9} Klein R.D....Rosenthal A. (1997)
5. Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2. (PubMed id 17522305)^{1, 9} Yoong L.F. and Too H.P. (2007)
6. Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells. (PubMed id 16081799)^{1, 9} Vargas-Leal V....Meinl E. (2005)
7. Glial cell-line derived neurotrophic factor and neurturin regulate the expressions of distinct miRNA precursors through the activation of GFRalpha2. (PubMed id 16895582)^{1, 9} Yoong L.F....Too H.P. (2006)
8. Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. (PubMed id 9286710)^{1, 9} Heuckeroth R.O....Milbrandt J. (1997)
9. Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. (PubMed id 9192899)^{1, 9} Buj-Bello A....Davies A.M. (1997)
10. Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata. (PubMed id 15829225)^{1, 9} Quartu M....Del Fiacco M. (2005)

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Products
for NRTN gene