External Ids for NRTN Gene
Previous GeneCards Identifiers for NRTN Gene
Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for NRTN Gene
NRTN (Neurturin) is a Protein Coding gene. Diseases associated with NRTN include Nrtn-Related Hirschsprung Disease and Hirschsprung Disease 1. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Developmental Biology. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is PSPN.
UniProtKB/Swiss-Prot for NRTN Gene
Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.