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NRSN2 Gene(Protein Coding)

Neurensin 2

GCID:
GC20P000346
GIFtS:
50
Genes Participants
UDN Logo

Aliases for NRSN2 Gene

Aliases for NRSN2 Gene

  • Neurensin 2 2 3 5
  • C20orf98 3 4
  • Chromosome 20 Open Reading Frame 98 2
  • Neurensin-2 3
  • DJ1103G7.6 3

External Ids for NRSN2 Gene

Previous HGNC Symbols for NRSN2 Gene

  • C20orf98

Previous GeneCards Identifiers for NRSN2 Gene

  • GC20P000276
  • GC20P000327

Summaries for NRSN2 Gene

GeneCards Summary for NRSN2 Gene

NRSN2 (Neurensin 2) is a Protein Coding gene. An important paralog of this gene is NRSN1.

UniProtKB/Swiss-Prot for NRSN2 Gene

  • May play a role in maintenance and/or transport of vesicles.

Gene Wiki entry for NRSN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRSN2 Gene

Genomics for NRSN2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for NRSN2 Gene

Enhancers for NRSN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G000307 2 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -36.7 -36661 4.2 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143 NRSN2 NRSN2-AS1 DEFB129 ZCCHC3 SOX12 SLC52A3
GH20G000399 2 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +54.9 54930 4.7 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 TBC1D20 ACTG1P3 NRSN2 RBCK1 ENSG00000229728 SOX12 TRIB3 ZCCHC3 CSNK2A1 GC20P000382
GH20G000377 1.4 ENCODE dbSUPER 12.6 +34.3 34340 6.5 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 TRIB3 TBC1D20 RBCK1 NRSN2 NRSN2-AS1 ENSG00000229728 SOX12 ACTG1P3 GC20P000387 GC20P000385
GH20G000323 1.4 ENCODE dbSUPER 12.2 -20.2 -20219 7.0 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 ZCCHC3 C20orf96 TBC1D20 NRSN2 NRSN2-AS1 DEFB132 DEFB129 SOX12 GC20P000328
GH20G000266 1.5 FANTOM5 ENCODE 10.3 -79.8 -79802 1.5 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 C20orf96 ZCCHC3 NRSN2-AS1 DEFB129 DEFB128 NRSN2 GC20P000265 ENSG00000272874
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRSN2 on UCSC Golden Path with GeneCards custom track

Promoters for NRSN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133402 874 2001 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 SLC30A9 ZNF263 SP3 MCM3

Transcription factor binding sites by QIAGEN in the NRSN2 gene promoter:

Genomic Location for NRSN2 Gene

Chromosome:
20
Start:
346,726 bp from pter
End:
359,660 bp from pter
Size:
12,935 bases
Orientation:
Plus strand

Genomic View for NRSN2 Gene

Genes around NRSN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRSN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRSN2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NRSN2 Gene

Proteins for NRSN2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NRSN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZP1-NRSN2_HUMAN
    Recommended name:
    Neurensin-2
    Protein Accession:
    Q9GZP1
    Secondary Accessions:
    • A8K3B2
    • Q6FII5
    • Q9NUD3

    Protein attributes for NRSN2 Gene

    Size:
    204 amino acids
    Molecular mass:
    21983 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRSN2 Gene

Protein Expression for NRSN2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NRSN2 Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for NRSN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NRSN2 Gene

Domains & Families for NRSN2 Gene

Protein Domains for NRSN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRSN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZP1

UniProtKB/Swiss-Prot:

NRSN2_HUMAN :
  • Belongs to the VMP family.
Family:
  • Belongs to the VMP family.
genes like me logo Genes that share domains with NRSN2: view

No data available for Gene Families for NRSN2 Gene

Function for NRSN2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NRSN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in maintenance and/or transport of vesicles.

Gene Ontology (GO) - Molecular Function for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NRSN2: view
genes like me logo Genes that share phenotypes with NRSN2: view

Animal Model Products

miRNA for NRSN2 Gene

miRTarBase miRNAs that target NRSN2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRSN2 Gene

Localization for NRSN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRSN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRSN2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle ISS --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with NRSN2: view

Pathways & Interactions for NRSN2 Gene

SuperPathways for NRSN2 Gene

PathCards logo More details on SuperPathways for NRSN2
No Data Available

Interacting Proteins for NRSN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371722%0d%0a9606.ENSP00000403397%0d%0a9606.ENSP00000357150%0d%0a
Selected Interacting proteins: Q9GZP1-NRSN2_HUMAN ENSP00000371722 for NRSN2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRSN2: view

No data available for Pathways by source and SIGNOR curated interactions for NRSN2 Gene

Drugs & Compounds for NRSN2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NRSN2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NRSN2 Gene

(16) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(190) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NRSN2 Gene

Neurensin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRSN2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: -
SP10: - -

Relevant External Links for NRSN2 Gene

GeneLoc Exon Structure for
NRSN2
ECgene alternative splicing isoforms for
NRSN2

Expression for NRSN2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRSN2 Gene

mRNA expression in normal human tissues for NRSN2 Gene
mRNA expression by BioGPS for NRSN2 GenemRNA expression by GTEx for NRSN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRSN2 Gene

This gene is overexpressed in Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for NRSN2 Gene

This gene is overexpressed in Frontal cortex (22.0), Testis (20.5), Retina (15.6), and Pancreas (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRSN2 Gene



Protein tissue co-expression partners for NRSN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRSN2 Gene:

NRSN2

SOURCE GeneReport for Unigene cluster for NRSN2 Gene:

Hs.416024

Evidence on tissue expression from TISSUES for NRSN2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NRSN2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRSN2 Gene

Orthologs for NRSN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRSN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia NRSN2 34 35
  • 99.35 (n)
dog
(Canis familiaris)
 Mammalia NRSN2 34 35
  • 88.51 (n)
cow
(Bos Taurus)
 Mammalia NRSN2 34 35
  • 86.8 (n)
rat
(Rattus norvegicus)
 Mammalia Nrsn2 34
  • 70.69 (n)
mouse
(Mus musculus)
 Mammalia Nrsn2 34 16 35
  • 69.85 (n)
oppossum
(Monodelphis domestica)
 Mammalia NRSN2 35
  • 54 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves NRSN2 35
  • 48 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia NRSN2 35
  • 62 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii NRSN2 35
  • 26 (a)
 OneToOne
Species where no ortholog for NRSN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRSN2 Gene

ENSEMBL:
Gene Tree for NRSN2 (if available)
TreeFam:
Gene Tree for NRSN2 (if available)

Paralogs for NRSN2 Gene

Paralogs for NRSN2 Gene

(1) SIMAP similar genes for NRSN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NRSN2: view

Variants for NRSN2 Gene

Sequence variations from dbSNP and Humsavar for NRSN2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000119801 -- 355,342(+) GATGA(A/T)CAGAG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000332962 -- 349,455(+) TCATT(C/T)GCAGT intron-variant
rs1000416098 -- 351,770(+) CTGAT(A/C)TTTGA intron-variant
rs1000680368 -- 346,083(+) GATCA(C/T)GCCAC downstream-variant-500B, upstream-variant-2KB
rs1000709181 -- 349,054(+) CAGCC(A/G)TGACA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NRSN2 Gene

Variant ID Type Subtype PubMed ID
dgv4219n100 CNV gain 25217958
dgv771e214 CNV gain 21293372
esv3893263 CNV loss 25118596
nsv458838 CNV loss 19166990
nsv585168 CNV loss 21841781

Variation tolerance for NRSN2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRSN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRSN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRSN2 Gene

Disorders for NRSN2 Gene

Relevant External Links for NRSN2

Genetic Association Database (GAD)
NRSN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRSN2

No disorders were found for NRSN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRSN2 Gene

Publications for NRSN2 Gene

  1. Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. (PMID: 26055238) Wang X. … Xia Q. (Dig. Dis. Sci. 2015) 2 3 64
  2. Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PMID: 16527258) Nakanishi K. … Taketani S. (Brain Res. 2006) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for NRSN2 Gene

Sources for NRSN2 Gene

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