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Aliases for NRSN2 Gene

Aliases for NRSN2 Gene

  • Neurensin 2 2 3 5
  • C20orf98 3 4
  • Chromosome 20 Open Reading Frame 98 2
  • DJ1103G7.6 3

External Ids for NRSN2 Gene

Previous HGNC Symbols for NRSN2 Gene

  • C20orf98

Previous GeneCards Identifiers for NRSN2 Gene

  • GC20P000276
  • GC20P000327

Summaries for NRSN2 Gene

GeneCards Summary for NRSN2 Gene

NRSN2 (Neurensin 2) is a Protein Coding gene. An important paralog of this gene is NRSN1.

UniProtKB/Swiss-Prot for NRSN2 Gene

  • May play a role in maintenance and/or transport of vesicles.

Gene Wiki entry for NRSN2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRSN2 Gene

Genomics for NRSN2 Gene

Regulatory Elements for NRSN2 Gene

Promoters for NRSN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRSN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRSN2 Gene

346,726 bp from pter
359,660 bp from pter
12,935 bases
Plus strand

Genomic View for NRSN2 Gene

Genes around NRSN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRSN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRSN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRSN2 Gene

Proteins for NRSN2 Gene

  • Protein details for NRSN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K3B2
    • Q6FII5
    • Q9NUD3

    Protein attributes for NRSN2 Gene

    204 amino acids
    Molecular mass:
    21983 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRSN2 Gene

Proteomics data for NRSN2 Gene at MOPED

Post-translational modifications for NRSN2 Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRSN2 Gene

Domains & Families for NRSN2 Gene

Protein Domains for NRSN2 Gene


Suggested Antigen Peptide Sequences for NRSN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VMP family.
  • Belongs to the VMP family.
genes like me logo Genes that share domains with NRSN2: view

No data available for Gene Families for NRSN2 Gene

Function for NRSN2 Gene

Molecular function for NRSN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in maintenance and/or transport of vesicles.
genes like me logo Genes that share phenotypes with NRSN2: view

Animal Model Products

miRNA for NRSN2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRSN2 Gene

Localization for NRSN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRSN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NRSN2 Gene COMPARTMENTS Subcellular localization image for NRSN2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with NRSN2: view

Pathways & Interactions for NRSN2 Gene

SuperPathways for NRSN2 Gene

No Data Available

Interacting Proteins for NRSN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9GZP1-NRSN2_HUMAN ENSP00000371722 for NRSN2 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for NRSN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NRSN2 Gene

Drugs & Compounds for NRSN2 Gene

No Compound Related Data Available

Transcripts for NRSN2 Gene

Unigene Clusters for NRSN2 Gene

Neurensin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRSN2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: -
SP10: - -

Relevant External Links for NRSN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRSN2 Gene

mRNA expression in normal human tissues for NRSN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRSN2 Gene

This gene is overexpressed in Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for NRSN2 Gene

This gene is overexpressed in Frontal cortex (22.0), Testis (20.5), Retina (15.6), and Pancreas (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRSN2 Gene

SOURCE GeneReport for Unigene cluster for NRSN2 Gene Hs.416024

genes like me logo Genes that share expression patterns with NRSN2: view

Protein tissue co-expression partners for NRSN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NRSN2 Gene

Orthologs for NRSN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRSN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NRSN2 35
  • 86.8 (n)
  • 86.63 (a)
NRSN2 36
  • 86 (a)
(Canis familiaris)
Mammalia NRSN2 35
  • 88.51 (n)
  • 93.1 (a)
NRSN2 36
  • 93 (a)
(Mus musculus)
Mammalia Nrsn2 35
  • 69.85 (n)
  • 58.79 (a)
Nrsn2 16
Nrsn2 36
  • 57 (a)
(Pan troglodytes)
Mammalia NRSN2 35
  • 99.35 (n)
  • 98.53 (a)
NRSN2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nrsn2 35
  • 70.69 (n)
  • 60.3 (a)
(Monodelphis domestica)
Mammalia NRSN2 36
  • 54 (a)
(Gallus gallus)
Aves NRSN2 36
  • 48 (a)
(Anolis carolinensis)
Reptilia NRSN2 36
  • 62 (a)
(Danio rerio)
Actinopterygii NRSN2 36
  • 26 (a)
Species with no ortholog for NRSN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRSN2 Gene

Gene Tree for NRSN2 (if available)
Gene Tree for NRSN2 (if available)

Paralogs for NRSN2 Gene

Paralogs for NRSN2 Gene

(1) SIMAP similar genes for NRSN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NRSN2: view

Variants for NRSN2 Gene

Sequence variations from dbSNP and Humsavar for NRSN2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_053738 -
rs17762763 - 353,213(+) AGATC(A/T)GCCTG reference, missense
rs35731713 - 353,498(+) GACCT(C/G)CACGT reference, missense
rs1001549 -- 354,581(+) AAATG(G/T)GCTCT utr-variant-3-prime
rs2050205 -- 350,710(+) TTTTA(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRSN2 Gene

Variant ID Type Subtype PubMed ID
nsv458838 CNV Loss 19166990
nsv912559 CNV Loss 21882294

Variation tolerance for NRSN2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRSN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRSN2 Gene

Disorders for NRSN2 Gene

Relevant External Links for NRSN2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NRSN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRSN2 Gene

Publications for NRSN2 Gene

  1. Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PMID: 16527258) Nakanishi K. … Taketani S. (Brain Res. 2006) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. SOX12 and NRSN2 are candidate genes for 20p13 subtelomeric deletions associated with developmental delay. (PMID: 24019301) An Y. … Shen Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013) 3
  4. Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma. (PMID: 19824122) Ma H.Q. … Xia J.C. (World J. Gastroenterol. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for NRSN2 Gene

Sources for NRSN2 Gene

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