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NRSN2 Gene

protein-coding   GIFtS: 50
GCID: GC20P000327

Neurensin 2

(Previous name: chromosome 20 open reading frame 98)
(Previous symbol: C20orf98)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neurensin 21 2
C20orf981 2 3
Chromosome 20 Open Reading Frame 981
dJ1103G7.62
neurensin-22

External Ids:    HGNC: 162291   Entrez Gene: 800232   Ensembl: ENSG000001258417   OMIM: 6106665   UniProtKB: Q9GZP13   

Export aliases for NRSN2 gene to outside databases

Previous GC identifer: GC20P000276


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NRSN2 Gene:
NRSN2 (neurensin 2) is a protein-coding gene. Diseases associated with NRSN2 include hepatocellular carcinoma, and neuronitis. An important paralog of this gene is NRSN1.

UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1
Function: May play a role in maintenance and/or transport of vesicles

Gene Wiki entry for NRSN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRSN2 gene promoter:
         HFH-3   Spz1   AML1a   Tal-1   Olf-1   E47   C/EBPalpha   CHOP-10   FOXI1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRSN2 promoter sequence
   Search Chromatin IP Primers for NRSN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRSN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

NRSN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRSN2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P000327:  view genomic region     (about GC identifiers)

Start:
327,370 bp from pter      End:
340,304 bp from pter
Size:
12,935 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1 (See protein sequence)
Recommended Name: Neurensin-2  
Size: 204 amino acids; 21983 Da
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Secondary accessions: A8K3B2 Q6FII5 Q9NUD3

Explore the universe of human proteins at neXtProt for NRSN2: NX_Q9GZP1

Explore proteomics data for NRSN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21
  • Modification sites at PhosphoSitePlus

  • See NRSN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079234.1  
    ENSEMBL proteins: 
     ENSP00000477135   ENSP00000371728   ENSP00000477349   ENSP00000371722   ENSP00000476925  
     ENSP00000477183   ENSP00000476543  

    NRSN2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024883 Neurensin

    Graphical View of Domain Structure for InterPro Entry Q9GZP1

    ProtoNet protein and cluster: Q9GZP1

    UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1
    Similarity: Belongs to the VMP family


    NRSN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRSN2_HUMAN, Q9GZP1
    Function: May play a role in maintenance and/or transport of vesicles

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    NRSN2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRSN2
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    miRNA
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    miRTarBase miRNAs that target NRSN2:
    hsa-mir-7-5p (MIRT025872), hsa-mir-331-3p (MIRT043401), hsa-let-7e-5p (MIRT051533), hsa-mir-671-5p (MIRT039265)

    Block miRNA regulation of human, mouse, rat NRSN2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate NRSN2:
    hsa-miR-3184 hsa-miR-631 hsa-miR-143 hsa-miR-324-3p hsa-miR-488 hsa-miR-766 hsa-miR-3661 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidNRSN2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NRSN2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRSN2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRSN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRSN2_HUMAN, Q9GZP1: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0016021integral component of membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle ----
    GO:0030133transport vesicle ISS--
    GO:0043025neuronal cell body IEA--

    NRSN2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRSN2
    Interactions:

        Search GeneGlobe Interaction Network for NRSN2

    2 Interacting proteins for NRSN2 (Q9GZP12, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANKZF1Q9H8Y52, 3MINT-65647 I2D: score=4 
    GOLM1Q8NBJ42, 3MINT-64979 I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    NRSN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRSN2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NRSN2 gene: 
    NM_024958.2  

    Unigene Cluster for NRSN2:

    Neurensin 2
    Hs.416024  [show with all ESTs]
    Unigene Representative Sequence: NM_024958
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000609179 ENST00000492242 ENST00000382291(uc002wdi.4) ENST00000609504
    ENST00000382285 ENST00000608467 ENST00000470439 ENST00000608736 ENST00000608875

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NRSN2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate NRSN2:
    hsa-miR-3184 hsa-miR-631 hsa-miR-143 hsa-miR-324-3p hsa-miR-488 hsa-miR-766 hsa-miR-3661 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidNRSN2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NRSN2
    Predesigned siRNA for gene silencing in human, mouse, rat NRSN2
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    OriGene qPCR primer pairs and template standards for NRSN2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRSN2
      QuantiTect SYBR Green Assays in human, mouse, rat NRSN2
      QuantiFast Probe-based Assays in human, mouse, rat NRSN2

    Additional mRNA sequence: 

    AF116644.1 AK026982.1 AK290527.1 AL136915.1 BC001963.1 CR533441.1 

    13 DOTS entries:

    DT.115052  DT.92429173  DT.100036296  DT.120814621  DT.100753414  DT.100781440  DT.120814645  DT.91639958 
    DT.120814623  DT.120814647  DT.120814667  DT.40223179  DT.97772793 

    Selected AceView cDNA sequences (see all 190):

    BM786491 AL521031 BX461594 AI339114 AF116644 C01911 CN482359 BX366483 
    CR612829 CR608694 BC001963 AL537771 CR599413 AA775842 BU165921 BE792891 
    BX375264 BU162800 AU279425 BM692549 NM_024958 BI752977 BU176302 BI752424 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NRSN2 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                                -     -     -     -           -                       -     -     -                     
    SP2:        -     -     -     -     -     -     -     -           -                       -     -     -                     
    SP3:                                -     -     -     -           -                                                         
    SP4:                                      -     -     -           -                                                         
    SP5:                                            -     -           -                                                         


    ECgene alternative splicing isoforms for NRSN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRSN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAACTAG
    NRSN2 Expression
    About this image


    NRSN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Brain (Nervous System)
             Cerebral Cortex
    NRSN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRSN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416024
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NRSN2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrsn21 , 5 neurensin 21, 5 69.85(n)1
    58.79(a)1
      2 (74.89 cM)5
    2287771  NM_001009948.11  NP_001009948.11 
     1523687555 
    chicken
    (Gallus gallus)
    Aves NRSN26
    neurensin 2
    48(a)
    1 ↔ 1
    20(10309574-10313704)
    lizard
    (Anolis carolinensis)
    Reptilia NRSN26
    neurensin 2
    62(a)
    1 ↔ 1
    GL343346.1(1090566-1095348)
    zebrafish
    (Danio rerio)
    Actinopterygii NRSN26
    neurensin 2
    26(a)
    1 ↔ 1
    19(28840570-28853078) ENSDARG00000056572


    ENSEMBL Gene Tree for NRSN2 (if available)
    TreeFam Gene Tree for NRSN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRSN2 gene
    NRSN12  
    1 SIMAP similar gene for NRSN2 using alignment to 6 protein entries:     NRSN2_HUMAN (see all proteins):
    NRSN1

    NRSN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRSN2 (see all 288)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505026971,2
    --325403(+) TGCCCA/GGCTAT 1 -- us2k10--------
    rs1846082351,2
    --325430(+) GAGACA/GGGGTT 1 -- us2k10--------
    rs1398022841,2
    --325432(+) GACGGA/GGTTTT 1 -- us2k10--------
    rs1422840571,2
    --325442(+) TGCCAG/TGTGGC 1 -- us2k10--------
    rs1885518821,2
    --325487(+) CACCCA/GCCTTG 1 -- us2k10--------
    rs1463912211,2
    --325648(+) TCTTGA/GCATCC 1 -- us2k10--------
    rs735745951,2
    C,F--325850(+) GGATCC/TCACCT 1 -- us2k13Minor allele frequency- T:0.21WA CSA 122
    rs60513531,2
    C,F,A,H--326016(+) CTCTTT/CGCTGA 1 -- us2k124Minor allele frequency- C:0.11NS EA NA CSA WA 2771
    rs1813183001,2
    --326017(+) TCTTTA/GCTGAT 1 -- us2k10--------
    rs796529591,2
    C,F--326099(+) TCAGAT/CCACAT 1 -- us2k11Minor allele frequency- C:0.03EA 120

    HapMap Linkage Disequilibrium report for NRSN2 (327370 - 340304 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NRSN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912559CNV Loss21882294
    nsv458838CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRSN2
    DNA2.0 Custom Variant and Variant Library Synthesis for NRSN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610666    OMIM disorders: --

    2 diseases for NRSN2:    
    About MalaCards
    hepatocellular carcinoma    neuronitis


    NRSN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NRSN2

    Export disorders for NRSN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRSN2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with NRSN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PubMed id 16527258)1, 3 Nakanishi K....Taketani S. (Brain Res. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)4 Luciano M....Deary I.J. (Biol Psychol 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma. (PubMed id 19824122)1 Ma H.Q....Xia J.C. (World J. Gastroenterol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80023 HGNC: 16229 AceView: C20orf98 Ensembl:ENSG00000125841 euGenes: HUgn80023
    ECgene: NRSN2 H-InvDB: NRSN2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRSN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRSN2 gene:
    Search GeneIP for patents involving NRSN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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