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Aliases for NRSN2 Gene

Aliases for NRSN2 Gene

  • Neurensin 2 2 3
  • C20orf98 3 4
  • Chromosome 20 Open Reading Frame 98 2
  • Neurensin-2 3
  • DJ1103G7.6 3

External Ids for NRSN2 Gene

Previous HGNC Symbols for NRSN2 Gene

  • C20orf98

Previous GeneCards Identifiers for NRSN2 Gene

  • GC20P000276
  • GC20P000327

Summaries for NRSN2 Gene

GeneCards Summary for NRSN2 Gene

NRSN2 (Neurensin 2) is a Protein Coding gene. An important paralog of this gene is NRSN1.

UniProtKB/Swiss-Prot for NRSN2 Gene

  • May play a role in maintenance and/or transport of vesicles

Gene Wiki entry for NRSN2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRSN2 Gene

Genomics for NRSN2 Gene

Regulatory Elements for NRSN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NRSN2 Gene

346,726 bp from pter
359,660 bp from pter
12,935 bases
Plus strand

Genomic View for NRSN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRSN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRSN2 Gene

Proteins for NRSN2 Gene

  • Protein details for NRSN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K3B2
    • Q6FII5
    • Q9NUD3

    Protein attributes for NRSN2 Gene

    204 amino acids
    Molecular mass:
    21983 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRSN2 Gene

Proteomics data for NRSN2 Gene at MOPED

Post-translational modifications for NRSN2 Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRSN2 Gene

Domains for NRSN2 Gene

Protein Domains for NRSN2 Gene


Suggested Antigen Peptide Sequences for NRSN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VMP family.
  • Belongs to the VMP family.
genes like me logo Genes that share domains with NRSN2: view

No data available for Gene Families for NRSN2 Gene

Function for NRSN2 Gene

Molecular function for NRSN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in maintenance and/or transport of vesicles

Gene Ontology (GO) - Molecular Function for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NRSN2: view

miRNA for NRSN2 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for NRSN2 Gene

Localization for NRSN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRSN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NRSN2 Gene COMPARTMENTS Subcellular localization image for NRSN2 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle --
GO:0030133 transport vesicle ISS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with NRSN2: view

Pathways for NRSN2 Gene

SuperPathways for NRSN2 Gene

No Data Available

Interacting Proteins for NRSN2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9GZP1-NRSN2_HUMAN ENSP00000371722 for NRSN2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRSN2: view

No data available for Pathways by source for NRSN2 Gene

Transcripts for NRSN2 Gene

Unigene Clusters for NRSN2 Gene

Neurensin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRSN2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: -
SP10: - -

Relevant External Links for NRSN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRSN2 Gene

mRNA expression in normal human tissues for NRSN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRSN2 Gene

This gene is overexpressed in Brain - Cortex (4.3).

Protein differential expression in normal tissues for NRSN2 Gene

This gene is overexpressed in Frontal cortex (22.0), Testis (20.5), Retina (15.6), and Pancreas (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NRSN2 Gene

SOURCE GeneReport for Unigene cluster for NRSN2 Gene Hs.416024

genes like me logo Genes that share expressions with NRSN2: view

Expression partners for NRSN2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NRSN2 Gene

Orthologs for NRSN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRSN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NRSN2 35
  • 86.8 (n)
  • 86.63 (a)
NRSN2 36
  • 86 (a)
(Canis familiaris)
Mammalia NRSN2 35
  • 88.51 (n)
  • 93.1 (a)
NRSN2 36
  • 93 (a)
(Mus musculus)
Mammalia Nrsn2 35
  • 69.85 (n)
  • 58.79 (a)
Nrsn2 16
Nrsn2 36
  • 57 (a)
(Pan troglodytes)
Mammalia NRSN2 35
  • 99.35 (n)
  • 98.53 (a)
NRSN2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nrsn2 35
  • 70.69 (n)
  • 60.3 (a)
(Monodelphis domestica)
Mammalia NRSN2 36
  • 54 (a)
(Gallus gallus)
Aves NRSN2 36
  • 48 (a)
(Anolis carolinensis)
Reptilia NRSN2 36
  • 62 (a)
(Danio rerio)
Actinopterygii NRSN2 36
  • 26 (a)
Species with no ortholog for NRSN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRSN2 Gene

Gene Tree for NRSN2 (if available)
Gene Tree for NRSN2 (if available)

Paralogs for NRSN2 Gene

Paralogs for NRSN2 Gene

(1) SIMAP similar genes for NRSN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NRSN2: view

Variants for NRSN2 Gene

Sequence variations from dbSNP and Humsavar for NRSN2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs548919645 -- 352,264(+) TGGCA(A/G)TGAGC intron-variant
rs548848024 -- 352,724(+) AGAGG(C/G)AGACG intron-variant
rs548786724 -- 352,222(+) GACTA(G/T)TCGGC intron-variant
rs548526676 -- 345,697(+) CAAAA(C/T)GCTTA upstream-variant-2KB
rs548469449 -- 344,753(+) CCACC(A/G)TGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRSN2 Gene

Variant ID Type Subtype PubMed ID
nsv458838 CNV Loss 19166990
nsv912559 CNV Loss 21882294

Relevant External Links for NRSN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRSN2 Gene

Disorders for NRSN2 Gene

Relevant External Links for NRSN2

Genetic Association Database (GAD)

No disorders were found for NRSN2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NRSN2 Gene

Publications for NRSN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PMID: 16527258) Nakanishi K. … Taketani S. (Brain Res. 2006) 2 3

Products for NRSN2 Gene

Sources for NRSN2 Gene

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