Aliases for NRSN2 Gene
Aliases for NRSN2 Gene
External Ids for NRSN2 Gene
- HGNC: 16229
- Entrez Gene: 80023
- Ensembl: ENSG00000125841
- OMIM: 610666
- UniProtKB: Q9GZP1
Previous HGNC Symbols for NRSN2 Gene
- C20orf98
Previous GeneCards Identifiers for NRSN2 Gene
- GC20P000276
- GC20P000327
Summaries for NRSN2 Gene
GeneCards Summary for NRSN2 Gene
NRSN2 (Neurensin 2) is a Protein Coding gene. An important paralog of this gene is NRSN1.
UniProtKB/Swiss-Prot for NRSN2 Gene
-
May play a role in maintenance and/or transport of vesicles.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRSN2 Gene
Genomics for NRSN2 Gene
GeneHancer (GH) Regulatory Elements for NRSN2 Gene
Promoters and enhancers for NRSN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NRSN2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NRSN2 Gene
Genomic Locations for NRSN2 Gene
- chr20:346,726-359,660
- (GRCh38/hg38)
- Size:
- 12,935 bases
- Orientation:
- Plus strand
- chr20:327,370-340,304
- (GRCh37/hg19)
Genomic View for NRSN2 Gene
Genes around NRSN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p13 by Ensembl
- 20p13 by Entrez Gene
- 20p13 by HGNC
NRSN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NRSN2 Gene
Proteins for NRSN2 Gene
-
Protein details for NRSN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZP1-NRSN2_HUMAN
- Recommended name:
- Neurensin-2
- Protein Accession:
- Q9GZP1
- A8K3B2
- Q6FII5
- Q9NUD3
Protein attributes for NRSN2 Gene
- Size:
- 204 amino acids
- Molecular mass:
- 21983 Da
- Quaternary structure:
- No Data Available
Protein Expression for NRSN2 Gene
Post-translational modifications for NRSN2 Gene
- Ubiquitination at isoforms=21
Other Protein References for NRSN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for NRSN2
- Novus Biologicals Antibodies for NRSN2
- Invitrogen Antibodies for NRSN2
- GeneTex NRSN2 antibody for NRSN2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NRSN2
Protein Products
-
OriGene Purified Proteins for NRSN2
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- antibodies-online: Search results for 3 available NRSN2 Proteins ranked by validation data
- Compare Top NRSN2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for NRSN2
-
Abcam proteins for NRSN2
Assay Products
No data available for DME Specific Peptides for NRSN2 Gene
Domains & Families for NRSN2 Gene
Gene Families for NRSN2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for NRSN2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9GZP1- Family:
-
- Belongs to the VMP family.
Function for NRSN2 Gene
Molecular function for NRSN2 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in maintenance and/or transport of vesicles.
Phenotypes From GWAS Catalog for NRSN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for NRSN2 Gene
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRSN2
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miRNA for NRSN2 Gene
- miRTarBase miRNAs that target NRSN2
miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for NRSN2 gene
Clone Products
- Sino Biological Human cDNA Clone for NRSN2
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NRSN2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NRSN2
-
ViGene Biosciences adenoviral particle packaged cDNA for NRSN2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NRSN2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NRSN2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRSN2 Gene
Localization for NRSN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NRSN2 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 2 |
| cytosol | 2 |
- Cytosol (2)
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030133 | transport vesicle | ISS | -- |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
Pathways & Interactions for NRSN2 Gene
No Data Available
Interacting Proteins for NRSN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for NRSN2 Gene
Transcripts for NRSN2 Gene
mRNA/cDNA for NRSN2 Gene
- (16) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (190) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for NRSN2
- genomics-online: gRNA clones - Search results for 99 available NRSN2 gene related products
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- Applied Biological Materials CRISPR for NRSN2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NRSN2
- GenScript: Design CRISPR guide RNA sequences for NRSN2
miRNA Products
- Search ViGene Biosciences for NRSN2
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for NRSN2
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- genomics-online: shRNA clones - Search results for 99 available NRSN2 gene related products
- Overview of 99 available NRSN2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NRSN2 gene
Clone Products
- Sino Biological Human cDNA Clone for NRSN2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NRSN2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NRSN2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NRSN2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||
| SP10: | - | - |
Expression for NRSN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for NRSN2 Gene
This gene is overexpressed in Brain - Cortex (x4.3).
This gene is overexpressed in Frontal cortex (22.0), Testis (20.5), Retina (15.6), and Pancreas (11.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRSN2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NRSN2 Gene:
NRSN2SOURCE GeneReport for Unigene cluster for NRSN2 Gene:
Hs.416024Evidence on tissue expression from TISSUES for NRSN2 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs for NRSN2
-
OriGene qPCR primer pairs and template standards for NRSN2
- genomics-online: primer clones - Search results for 99 available NRSN2 gene related products
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No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRSN2 Gene
Orthologs for NRSN2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NRSN2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | NRSN2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NRSN2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nrsn2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Nrsn2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NRSN2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NRSN2 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NRSN2 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | NRSN2 34 |
|
OneToOne |
- Species where no ortholog for NRSN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for NRSN2 Gene
(1) SIMAP similar genes for NRSN2 Gene using alignment to 6 proteins:
Variants for NRSN2 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000119801 | -- | 355,342(+) | T/A | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
| rs1000332962 | -- | 349,455(+) | C/T | intron_variant | |
| rs1000416098 | -- | 351,770(+) | C/A | intron_variant | |
| rs1000680368 | -- | 346,083(+) | T/C | upstream_transcript_variant | |
| rs1000709181 | -- | 349,054(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4219n100 | CNV | gain | 25217958 |
| dgv771e214 | CNV | gain | 21293372 |
| esv3893263 | CNV | loss | 25118596 |
| nsv458838 | CNV | loss | 19166990 |
| nsv585168 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.10;
75.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NRSN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NRSN2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRSN2 Gene
Disorders for NRSN2 Gene
Additional Disease Information for NRSN2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NRSN2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRSN2 Gene
Publications for NRSN2 Gene
- Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. (PMID: 26055238) Wang X … Xia Q (Digestive diseases and sciences 2015) 2 3 58
- Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PMID: 16527258) Nakanishi K … Taketani S (Brain research 2006) 2 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
Products for NRSN2 Gene
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- Invitrogen Antibodies for NRSN2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for NRSN2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NRSN2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 38 available NRSN2 Antibodies ranked by validation data
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- antibodies-online: Search results for available NRSN2 related products ranked by validation data
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- Quality Products:
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Sources for NRSN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
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