NRSN2 Gene
protein-coding GIFtS: 45
GCID: GC20P000327
|
|
neurensin 2(Previous name: chromosome 20 open reading frame 98 )
(Previous symbol: C20orf98)
| |
Aliases
for NRSN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neurensin 21 2 | | C20orf981 2 3 | | DJ1103G7.61 | | Chromosome 20 Open Reading Frame 981 | | Neurensin-21 |
Export aliases for NRSN2 gene to outside databasesPrevious GC identifer: GC20P000276 |
Summaries
for NRSN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1Function: May play a role in maintenance and/or transport of vesicles
Gene Wiki entry for NRSN2
|
Genomic Views
for NRSN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NRSN2 gene promoter:
HFH-3 Spz1 AML1a Tal-1 Olf-1 E47 C/EBPalpha CHOP-10 FOXI1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NRSN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRSN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13NRSN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P000327: view genomic region
(about GC identifiers)
Start:
|
327,370 bp from pter |
End:
|
335,512 bp from pter |
Size:
|
8,143 bases |
Orientation:
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plus strand |
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Proteins
for NRSN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1 (See
protein sequence)Recommended Name: Neurensin-2 Size: 204 amino acids; 21983 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Caution: It is uncertain whether Met-1 or Met-2 is the initiator
Secondary accessions: A8K3B2 Q6FII5 Q9NUD3Explore the universe of human proteins at neXtProt for NRSN2: NX_Q9GZP1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9GZP1
NRSN2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_079234.1
ENSEMBL proteins: ENSP00000371728 ENSP00000371722
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NRSN2 for ontologies About GeneDecksing
NRSN2 Antibody Products:
Assay Products for NRSN2: |
Protein
Domains /
Families
for NRSN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NRSN2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9GZP1ProtoNet protein and cluster: Q9GZP1 UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1Similarity: Belongs to the VMP family |
Function
for NRSN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1Function: May play a role in maintenance and/or transport of vesicles
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRSN2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRSN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NRSN2 (NM_024958) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRSN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRSN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRSN2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
NRSN2 for ontologies About GeneDecksing
|
Pathways & Interactions
for NRSN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRSN2
2 Interacting proteins for NRSN2 (Q9GZP12, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
NRSN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NRSN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NRSN2
Search CenterWatch for drugs/clinical trials and news about NRSN2
|
Transcripts
for NRSN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NRSN2 gene: NM_024958.2 Unigene Cluster for NRSN2: Neurensin 2 Hs.416024 [show with all ESTs]Unigene Representative Sequence: NM_0249584 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000492242 ENST00000382291(uc002wdi.4) ENST00000382285 ENST00000470439
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRSN2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRSN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NRSN2 (NM_024958) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRSN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRSN2 |
Additional cDNA sequence: AF116644.1 AK026982.1 AK290527.1 AL136915.1 BC001963.1 CR533441.1 13 DOTS entries: DT.115052 DT.92429173 DT.100036296 DT.120814621 DT.100753414 DT.100781440 DT.120814645 DT.91639958 DT.120814623 DT.120814647 DT.120814667 DT.40223179 DT.97772793 24/190 AceView cDNA sequences (see all 190): CN482359 AA775842 BQ678542 NM_024958 BP372221 C01911 BC001963 CR612829 AI341814 BX375264 BQ067071 CR608694 BI752977 AI339114 BF511356 BI752424 BU162800 BX461594 AL136915 BM786491 AU279425 AL521031 AL537771 AI671560
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NRSN2 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c |
|---|
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| SP1: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NRSN2
|
Expression
for NRSN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NRSN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGGAACTAG
About this image
Genevestigator expression for NRSN2
SOURCE GeneReport for Unigene cluster: Hs.416024
SABiosciences Custom PCR Arrays for NRSN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRSN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NRSN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRSN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRSN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRSN2 |
Orthologs
for NRSN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NRSN2 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for NRSN2 (if available)
TreeFam Gene Tree for NRSN2 (if available) |
Paralogs
for NRSN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NRSN2 gene
- NRSN12
1 SIMAP similar gene for NRSN2 using alignment to 1 protein entry: NRSN2_HUMAN:NRSN1
NRSN2 for paralogs About GeneDecksing
|
Genomic Variants
for NRSN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NRSN2 (327370 - 335512 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NRSN2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRSN2 |
|
Disorders
/ Diseases
for NRSN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NRSN2 for disorders About GeneDecksing
OMIM gene information: 610666
OMIM disorders: --
2  diseases for NRSN2: About MalaCardshepatocellular carcinoma carcinoma
Export disorders for NRSN2 gene to outside databases
|
Publications
for NRSN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NRSN2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with NRSN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PubMed id 16527258)1, 3 Nakanishi K....Taketani S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Decreased expression of Neurensin-2 correlates with p oor prognosis in hepatocellular carcinoma. (PubMed id 19824122)1 Ma H.Q....Xia J.C. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for NRSN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NRSN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NRSN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NRSN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NRSN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NRSN2 gene:
Search GeneIP for patents involving NRSN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NRSN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NRSN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRSN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRSN2 | | | OriGene Protein Over-expression Lysate for NRSN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NRSN2 | | OriGene 3'-UTR Clone for NRSN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRSN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRSN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NRSN2 | | OriGene Custom Protein Services for NRSN2 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NRSN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRSN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRSN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRSN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRSN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRSN2 |
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 | | | NRSN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRSN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for NRSN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRSN2 |
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