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NRSN2 Gene

protein-coding GIFtS: 50
GCID: GC20P000327

Neurensin 2

(Previous name: chromosome 20 open reading frame 98)
(Previous symbol: C20orf98)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Neurensin 2¹ ²
C20orf98¹ ² ³
Chromosome 20 Open Reading Frame 98¹
dJ1103G7.6²
neurensin-2²

External Ids:	HGNC: 16229¹	Entrez Gene: 80023²	Ensembl: ENSG00000125841⁷	OMIM: 610666⁵	UniProtKB: Q9GZP1³

Export aliases for NRSN2 gene to outside databases

Previous GC identifer: GC20P000276

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NRSN2 Gene:

NRSN2 (neurensin 2) is a protein-coding gene. Diseases associated with NRSN2 include hepatocellular carcinoma, and neuronitis. An important paralog of this gene is NRSN1.

UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1

Function: May play a role in maintenance and/or transport of vesicles

Gene Wiki entry for NRSN2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000020.11 NT_011387.9 NC_018931.2

Regulatory elements:

Regulatory transcription factor binding sites in the NRSN2 gene promoter:
HFH-3 Spz1 AML1a Tal-1 Olf-1 E47 C/EBPalpha CHOP-10 FOXI1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NRSN2 promoter sequence

Search Chromatin IP Primers for NRSN2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRSN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

NRSN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRSN2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P000327: view genomic region (about GC identifiers)

Start:	327,370 bp from pter	End:	340,304 bp from pter
Size:	12,935 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1 (See protein sequence)

Recommended Name: Neurensin-2

Size: 204 amino acids; 21983 Da

Caution: It is uncertain whether Met-1 or Met-2 is the initiator

Secondary accessions: A8K3B2 Q6FII5 Q9NUD3

Explore the universe of human proteins at neXtProt for NRSN2: NX_Q9GZP1

Explore proteomics data for NRSN2 at MOPED

Post-translational modifications:

Ubiquitination² at Lys21

Modification sites at PhosphoSitePlus

See NRSN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_079234.1

ENSEMBL proteins:

ENSP00000477135 ENSP00000371728 ENSP00000477349 ENSP00000371722 ENSP00000476925

ENSP00000477183 ENSP00000476543

NRSN2 Human Recombinant Protein Products:

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NRSN2 Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR024883 Neurensin

Graphical View of Domain Structure for InterPro Entry Q9GZP1

ProtoNet protein and cluster: Q9GZP1

UniProtKB/Swiss-Prot: NRSN2_HUMAN, Q9GZP1

Similarity: Belongs to the VMP family

NRSN2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NRSN2_HUMAN, Q9GZP1

Function: May play a role in maintenance and/or transport of vesicles

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

NRSN2 for ontologies About GeneDecksing

Animal Models:

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miRNA Products:		miRTarBase miRNAs that target NRSN2: hsa-mir-7-5p (MIRT025872), hsa-mir-331-3p (MIRT043401), hsa-let-7e-5p (MIRT051533), hsa-mir-671-5p (MIRT039265)

		Block miRNA regulation of human, mouse, rat NRSN2 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate NRSN2:
		hsa-miR-3184 hsa-miR-631 hsa-miR-143 hsa-miR-324-3p hsa-miR-488 hsa-miR-766 hsa-miR-3661 hsa-miR-423-5p

		SwitchGear 3'UTR luciferase reporter plasmid: NRSN2 3' UTR sequence

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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRSN2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NRSN2_HUMAN, Q9GZP1: Membrane; Multi-pass membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
cytosol	1
nucleus	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	--
GO:0016021	integral component of membrane	IEA	--
GO:0016023	cytoplasmic membrane-bounded vesicle	--	--
GO:0030133	transport vesicle	ISS	--
GO:0043025	neuronal cell body	IEA	--

NRSN2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for NRSN2
Interactions:

Search GeneGlobe Interaction Network for NRSN2

2 Interacting proteins for NRSN2 (Q9GZP1^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANKZF1	Q9H8Y5²^,³	MINT-65647 I2D: score=4
GOLM1	Q8NBJ4²^,³	MINT-64979 I2D: score=4

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

NRSN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for NRSN2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NRSN2 gene:

NM_024958.2

Unigene Cluster for NRSN2:

Neurensin 2

Hs.416024 [show with all ESTs]

Unigene Representative Sequence: NM_024958

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000609179 ENST00000492242 ENST00000382291(uc002wdi.4) ENST00000609504

ENST00000382285 ENST00000608467 ENST00000470439 ENST00000608736 ENST00000608875

miRNA Products:		Block miRNA regulation of human, mouse, rat NRSN2 using miScript Target Protectors
		8 qRT-PCR Assays for microRNAs that regulate NRSN2:
		hsa-miR-3184 hsa-miR-631 hsa-miR-143 hsa-miR-324-3p hsa-miR-488 hsa-miR-766 hsa-miR-3661 hsa-miR-423-5p

		SwitchGear 3'UTR luciferase reporter plasmid: NRSN2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NRSN2
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		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NRSN2
		QuantiTect SYBR Green Assays in human, mouse, rat NRSN2
		QuantiFast Probe-based Assays in human, mouse, rat NRSN2

Additional mRNA sequence:

AF116644.1 AK026982.1 AK290527.1 AL136915.1 BC001963.1 CR533441.1

13 DOTS entries:

DT.115052 DT.92429173 DT.100036296 DT.120814621 DT.100753414 DT.100781440 DT.120814645 DT.91639958

DT.120814623 DT.120814647 DT.120814667 DT.40223179 DT.97772793

Selected AceView cDNA sequences (see all 190):

BM786491 AL521031 BX461594 AI339114 AF116644 C01911 CN482359 BX366483

CR612829 CR608694 BC001963 AL537771 CR599413 AA775842 BU165921 BE792891

BX375264 BU162800 AU279425 BM692549 NM_024958 BI752977 BU176302 BI752424

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for NRSN2 (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c
SP1:											-		-		-		-				-								-		-		-
SP2:			-		-		-		-		-		-		-		-				-								-		-		-
SP3:											-		-		-		-				-
SP4:													-		-		-				-
SP5:															-		-				-

ECgene alternative splicing isoforms for NRSN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NRSN2 expression in normal human tissues (normalized intensities) NRSN2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CAGGAACTAG

About this image

NRSN2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Smooth Muscle (Muscoskeletal System)
Juxtaglomerular Cells Afferent Arteriole

Kidney (Urinary System)
Juxtaglomerular Cells Afferent Arteriole

Brain (Nervous System)
Cerebral Cortex

NRSN2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NRSN2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.416024

Custom PCR Arrays for NRSN2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRSN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NRSN2 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nrsn2^{1 , 5}	neurensin 2^{1, 5}	69.85(n)¹ 58.79(a)¹		2 (74.89 cM)⁵ 228777¹ NM_001009948.1¹ NP_001009948.1¹ 152368755⁵
chicken (Gallus gallus)	Aves	NRSN2⁶	neurensin 2	48(a)	1 ↔ 1	20(10309574-10313704)
lizard (Anolis carolinensis)	Reptilia	NRSN2⁶	neurensin 2	62(a)	1 ↔ 1	GL343346.1(1090566-1095348)
zebrafish (Danio rerio)	Actinopterygii	NRSN2⁶	neurensin 2	26(a)	1 ↔ 1	19(28840570-28853078) ENSDARG00000056572

ENSEMBL Gene Tree for NRSN2 (if available)
TreeFam Gene Tree for NRSN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NRSN2 gene

NRSN1²

1 SIMAP similar gene for NRSN2 using alignment to 6 protein entries: NRSN2_HUMAN (see all proteins):

NRSN1

NRSN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150502697^1,2		--	325403(+)	`TGCCCA/GGCTAT`	1	--	us2k¹		0	--	--	--	--
rs184608235^1,2		--	325430(+)	`GAGACA/GGGGTT`	1	--	us2k¹		0	--	--	--	--
rs139802284^1,2		--	325432(+)	`GACGGA/GGTTTT`	1	--	us2k¹		0	--	--	--	--
rs142284057^1,2		--	325442(+)	`TGCCAG/TGTGGC`	1	--	us2k¹		0	--	--	--	--
rs188551882^1,2		--	325487(+)	`CACCCA/GCCTTG`	1	--	us2k¹		0	--	--	--	--
rs146391221^1,2		--	325648(+)	`TCTTGA/GCATCC`	1	--	us2k¹		0	--	--	--	--
rs73574595^1,2	C,F	--	325850(+)	`GGATCC/TCACCT`	1	--	us2k¹		3		WA CSA	122
rs6051353^1,2	C,F,A,H	--	326016(+)	`CTCTTT/CGCTGA`	1	--	us2k¹		24		NS EA NA CSA WA	2771
rs181318300^1,2		--	326017(+)	`TCTTTA/GCTGAT`	1	--	us2k¹		0	--	--	--	--
rs79652959^1,2	C,F	--	326099(+)	`TCAGAT/CCACAT`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for NRSN2 (327370 - 340304 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for NRSN2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv912559	CNV	Loss	21882294
nsv458838	CNV	Loss	19166990

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NRSN2

DNA2.0 Custom Variant and Variant Library Synthesis for NRSN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610666 OMIM disorders: --

2 diseases for NRSN2: About MalaCards

hepatocellular carcinoma neuronitis

NRSN2 for disorders About GeneDecksing

Genetic Association Database (GAD): NRSN2

Export disorders for NRSN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NRSN2 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with NRSN2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PubMed id 16527258)^{1, 3} Nakanishi K....Taketani S. (Brain Res. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (Nature 2001)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (Genome Res. 2001)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (amp 2011)
Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)⁴ Luciano M....Deary I.J. (Biol Psychol 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma. (PubMed id 19824122)¹ Ma H.Q....Xia J.C. (World J. Gastroenterol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80023	HGNC: 16229	AceView: C20orf98	Ensembl:ENSG00000125841	euGenes: HUgn80023
ECgene: NRSN2	H-InvDB: NRSN2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NRSN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NRSN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NRSN2 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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NRSN2 Gene

Neurensin 2

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NRSN2 Gene

Neurensin 2

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