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Aliases for NRSN2 Gene

Aliases for NRSN2 Gene

  • Neurensin 2 2 3 5
  • C20orf98 3 4
  • Chromosome 20 Open Reading Frame 98 2
  • Neurensin-2 3
  • DJ1103G7.6 3

External Ids for NRSN2 Gene

Previous HGNC Symbols for NRSN2 Gene

  • C20orf98

Previous GeneCards Identifiers for NRSN2 Gene

  • GC20P000276
  • GC20P000327

Summaries for NRSN2 Gene

GeneCards Summary for NRSN2 Gene

NRSN2 (Neurensin 2) is a Protein Coding gene. An important paralog of this gene is NRSN1.

UniProtKB/Swiss-Prot for NRSN2 Gene

  • May play a role in maintenance and/or transport of vesicles.

Gene Wiki entry for NRSN2 Gene

Additional gene information for NRSN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRSN2 Gene

Genomics for NRSN2 Gene

GeneHancer (GH) Regulatory Elements for NRSN2 Gene

Promoters and enhancers for NRSN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I000345 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.0 960 3.7 MLX ZFP64 FEZF1 DMAP1 SLC30A9 ZNF213 E2F8 ZNF143 MCM3 SP3 LOC101929937 NRSN2 NRSN2-AS1 GC20M000344 ACTG1P3 TBC1D20 RBCK1 SOX12 SLC52A3
GH20I000377 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.7 +34.3 34340 6.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TRIB3 GC20P000382 GC20P000384 GC20P000385 GC20P000386 GC20P000387 GC20P000389 GC20P000390 SOX12 TBC1D20
GH20I000323 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.2 -20.2 -20219 7 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 SOX12 TBC1D20 ACTG1P3 ZCCHC3 C20orf96 NRSN2-AS1 NRSN2 DEFB132 RBCK1 DEFB129
GH20I000307 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -36.7 -36660 4.2 ELF3 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 BMI1 RAD21 ZNF366 SP5 NRSN2 NRSN2-AS1 DEFB129 ZCCHC3 SOX12 SLC52A3
GH20I000399 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +54.9 54929 4.7 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 TBC1D20 NRSN2 ACTG1P3 RBCK1 TRIB3 ZCCHC3 CSNK2A1 GC20P000382 GC20P000386 GC20P000390
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NRSN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRSN2 gene promoter:

Genomic Locations for NRSN2 Gene

Genomic Locations for NRSN2 Gene
chr20:346,726-359,660
(GRCh38/hg38)
Size:
12,935 bases
Orientation:
Plus strand
chr20:327,370-340,304
(GRCh37/hg19)

Genomic View for NRSN2 Gene

Genes around NRSN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRSN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRSN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRSN2 Gene

Proteins for NRSN2 Gene

  • Protein details for NRSN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZP1-NRSN2_HUMAN
    Recommended name:
    Neurensin-2
    Protein Accession:
    Q9GZP1
    Secondary Accessions:
    • A8K3B2
    • Q6FII5
    • Q9NUD3

    Protein attributes for NRSN2 Gene

    Size:
    204 amino acids
    Molecular mass:
    21983 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRSN2 Gene

Post-translational modifications for NRSN2 Gene

No data available for DME Specific Peptides for NRSN2 Gene

Domains & Families for NRSN2 Gene

Gene Families for NRSN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for NRSN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRSN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZP1

UniProtKB/Swiss-Prot:

NRSN2_HUMAN :
  • Belongs to the VMP family.
Family:
  • Belongs to the VMP family.
genes like me logo Genes that share domains with NRSN2: view

Function for NRSN2 Gene

Molecular function for NRSN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in maintenance and/or transport of vesicles.

Phenotypes From GWAS Catalog for NRSN2 Gene

Gene Ontology (GO) - Molecular Function for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NRSN2: view
genes like me logo Genes that share phenotypes with NRSN2: view

miRNA for NRSN2 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRSN2 Gene

Localization for NRSN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRSN2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRSN2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle ISS --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with NRSN2: view

Pathways & Interactions for NRSN2 Gene

SuperPathways for NRSN2 Gene

No Data Available

Interacting Proteins for NRSN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371722%0d%0a9606.ENSP00000403397%0d%0a9606.ENSP00000357150%0d%0a
Selected Interacting proteins: ENSP00000371722 Q9GZP1-NRSN2_HUMAN for NRSN2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NRSN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRSN2: view

No data available for Pathways by source and SIGNOR curated interactions for NRSN2 Gene

Drugs & Compounds for NRSN2 Gene

No Compound Related Data Available

Transcripts for NRSN2 Gene

Unigene Clusters for NRSN2 Gene

Neurensin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRSN2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: -
SP10: - -

Relevant External Links for NRSN2 Gene

GeneLoc Exon Structure for
NRSN2
ECgene alternative splicing isoforms for
NRSN2

Expression for NRSN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRSN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRSN2 Gene

This gene is overexpressed in Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for NRSN2 Gene

This gene is overexpressed in Frontal cortex (22.0), Testis (20.5), Retina (15.6), and Pancreas (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRSN2 Gene



Protein tissue co-expression partners for NRSN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRSN2 Gene:

NRSN2

SOURCE GeneReport for Unigene cluster for NRSN2 Gene:

Hs.416024

Evidence on tissue expression from TISSUES for NRSN2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NRSN2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRSN2 Gene

Orthologs for NRSN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRSN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRSN2 33 34
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia NRSN2 33 34
  • 88.51 (n)
cow
(Bos Taurus)
Mammalia NRSN2 33 34
  • 86.8 (n)
rat
(Rattus norvegicus)
Mammalia Nrsn2 33
  • 70.69 (n)
mouse
(Mus musculus)
Mammalia Nrsn2 33 16 34
  • 69.85 (n)
oppossum
(Monodelphis domestica)
Mammalia NRSN2 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRSN2 34
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRSN2 34
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NRSN2 34
  • 26 (a)
OneToOne
Species where no ortholog for NRSN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRSN2 Gene

ENSEMBL:
Gene Tree for NRSN2 (if available)
TreeFam:
Gene Tree for NRSN2 (if available)

Paralogs for NRSN2 Gene

Paralogs for NRSN2 Gene

(1) SIMAP similar genes for NRSN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NRSN2: view

Variants for NRSN2 Gene

Sequence variations from dbSNP and Humsavar for NRSN2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000119801 -- 355,342(+) T/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000332962 -- 349,455(+) C/T intron_variant
rs1000416098 -- 351,770(+) C/A intron_variant
rs1000680368 -- 346,083(+) T/C upstream_transcript_variant
rs1000709181 -- 349,054(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRSN2 Gene

Variant ID Type Subtype PubMed ID
dgv4219n100 CNV gain 25217958
dgv771e214 CNV gain 21293372
esv3893263 CNV loss 25118596
nsv458838 CNV loss 19166990
nsv585168 CNV loss 21841781

Variation tolerance for NRSN2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRSN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRSN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRSN2 Gene

Disorders for NRSN2 Gene

Additional Disease Information for NRSN2

No disorders were found for NRSN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRSN2 Gene

Publications for NRSN2 Gene

  1. Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. (PMID: 26055238) Wang X … Xia Q (Digestive diseases and sciences 2015) 2 3 58
  2. Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. (PMID: 16527258) Nakanishi K … Taketani S (Brain research 2006) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58

Products for NRSN2 Gene

Sources for NRSN2 Gene

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