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Aliases for NRSN1 Gene

Aliases for NRSN1 Gene

  • Neurensin 1 2 3 5
  • Vesicular Membrane Protein P24 2 3 4
  • Vesicular Membrane Protein Of 24 KDa 3 4
  • Neuro-P24 3 4
  • VMP 3 4
  • Vesicular Membrain Protein P24 3
  • P24 3

External Ids for NRSN1 Gene

Previous HGNC Symbols for NRSN1 Gene

  • VMP

Previous GeneCards Identifiers for NRSN1 Gene

  • GC06P024235

Summaries for NRSN1 Gene

GeneCards Summary for NRSN1 Gene

NRSN1 (Neurensin 1) is a Protein Coding gene. Diseases associated with NRSN1 include louse-borne relapsing fever. An important paralog of this gene is NRSN2.

UniProtKB/Swiss-Prot for NRSN1 Gene

  • May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity).

Gene Wiki entry for NRSN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRSN1 Gene

Genomics for NRSN1 Gene

Regulatory Elements for NRSN1 Gene

Enhancers for NRSN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NRSN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRSN1 Gene

Chromosome:
6
Start:
24,126,122 bp from pter
End:
24,154,900 bp from pter
Size:
28,779 bases
Orientation:
Plus strand

Genomic View for NRSN1 Gene

Genes around NRSN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRSN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRSN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRSN1 Gene

Proteins for NRSN1 Gene

  • Protein details for NRSN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ57-NRSN1_HUMAN
    Recommended name:
    Neurensin-1
    Protein Accession:
    Q8IZ57
    Secondary Accessions:
    • B2RAV4
    • Q8N8R6
    • Q96P21

    Protein attributes for NRSN1 Gene

    Size:
    195 amino acids
    Molecular mass:
    21475 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRSN1 Gene

Proteomics data for NRSN1 Gene at MOPED

Post-translational modifications for NRSN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRSN1 Gene

Antibody Products

No data available for DME Specific Peptides for NRSN1 Gene

Domains & Families for NRSN1 Gene

Protein Domains for NRSN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRSN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZ57

UniProtKB/Swiss-Prot:

NRSN1_HUMAN :
  • Belongs to the VMP family.
Family:
  • Belongs to the VMP family.
genes like me logo Genes that share domains with NRSN1: view

No data available for Gene Families for NRSN1 Gene

Function for NRSN1 Gene

Molecular function for NRSN1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory consolidation (By similarity).
genes like me logo Genes that share phenotypes with NRSN1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRSN1 Gene

Localization for NRSN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRSN1 Gene

Membrane; Multi-pass membrane protein. Note=Localizes mainly to neurites.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRSN1 Gene COMPARTMENTS Subcellular localization image for NRSN1 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NRSN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA,ISS --
GO:0030133 transport vesicle TAS 12463420
GO:0043025 neuronal cell body IEA,ISS --
genes like me logo Genes that share ontologies with NRSN1: view

Pathways & Interactions for NRSN1 Gene

SuperPathways for NRSN1 Gene

No Data Available

Interacting Proteins for NRSN1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367752%0d%0a9606.ENSP00000296695%0d%0a9606.ENSP00000359375%0d%0a
Selected Interacting proteins: Q8IZ57-NRSN1_HUMAN ENSP00000367752 for NRSN1 Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for NRSN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NRSN1 Gene

Drugs & Compounds for NRSN1 Gene

No Compound Related Data Available

Transcripts for NRSN1 Gene

Unigene Clusters for NRSN1 Gene

Neurensin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRSN1 Gene

No ASD Table

Relevant External Links for NRSN1 Gene

GeneLoc Exon Structure for
NRSN1
ECgene alternative splicing isoforms for
NRSN1

Expression for NRSN1 Gene

mRNA expression in normal human tissues for NRSN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRSN1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x7.3), Brain - Frontal Cortex (BA9) (x7.1), Brain - Cortex (x6.2), Brain - Hypothalamus (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for NRSN1 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRSN1 Gene



SOURCE GeneReport for Unigene cluster for NRSN1 Gene Hs.726270

mRNA Expression by UniProt/SwissProt for NRSN1 Gene

Q8IZ57-NRSN1_HUMAN
Tissue specificity: Expressed in brain. Not detectable in other tissues tested.
genes like me logo Genes that share expression patterns with NRSN1: view

Protein tissue co-expression partners for NRSN1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NRSN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRSN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRSN1 35
  • 89.06 (n)
  • 92.82 (a)
NRSN1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRSN1 35
  • 83.59 (n)
  • 85.13 (a)
NRSN1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrsn1 35
  • 86.84 (n)
  • 92.31 (a)
Nrsn1 16
Nrsn1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRSN1 35
  • 99.32 (n)
  • 100 (a)
NRSN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrsn1 35
  • 86.32 (n)
  • 92.31 (a)
oppossum
(Monodelphis domestica)
Mammalia NRSN1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRSN1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRSN1 35
  • 76.75 (n)
  • 76.92 (a)
NRSN1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRSN1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrsn1 35
  • 74.69 (n)
  • 78.53 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
nrsn1 35
  • 63.53 (n)
  • 61.78 (a)
nrsn1 36
  • 60 (a)
OneToOne
Species with no ortholog for NRSN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRSN1 Gene

ENSEMBL:
Gene Tree for NRSN1 (if available)
TreeFam:
Gene Tree for NRSN1 (if available)

Paralogs for NRSN1 Gene

Paralogs for NRSN1 Gene

(1) SIMAP similar genes for NRSN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NRSN1: view

Variants for NRSN1 Gene

Sequence variations from dbSNP and Humsavar for NRSN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17299946 - 24,134,448(+) CCTCA(A/G)TTTGG reference, missense
rs11544636 - 24,145,668(+) ACACA(C/T)ATGCT reference, missense
rs1053047 -- 24,147,255(+) TGTTC(A/G)TCTCA utr-variant-3-prime
rs6149483 -- 24,126,152(+) GGGGA(-/GGC/GGCGGCGGCGGC)GGCGG upstream-variant-2KB
rs1356999 -- 24,127,514(-) TGCCA(A/T)CTATA intron-variant

Variation tolerance for NRSN1 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRSN1 Gene

HapMap Linkage Disequilibrium report
NRSN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NRSN1 Gene

Disorders for NRSN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRSN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
louse-borne relapsing fever
  • relapsing fever, louse-borne
- elite association - COSMIC cancer census association via MalaCards
Search NRSN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRSN1

Genetic Association Database (GAD)
NRSN1
Human Genome Epidemiology (HuGE) Navigator
NRSN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRSN1
genes like me logo Genes that share disorders with NRSN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRSN1 Gene

Publications for NRSN1 Gene

  1. Cloning, expression and characterization of a novel human VMP gene. (PMID: 12463420) Cheng C. … Mao Y. (Mol. Biol. Rep. 2002) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3
  4. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for NRSN1 Gene

Sources for NRSN1 Gene

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