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NRROS Gene

protein-coding   GIFtS: 34
GCID: GC03P196374

Negative Regulator Of Reactive Oxygen Species

(Previous name: leucine rich repeat containing 33)
(Previous symbol: LRRC33)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Negative Regulator Of Reactive Oxygen Species1 2     ELLP30302
LRRC331 2 3 5     GARPL12
Leucine Rich Repeat Containing 331 2     UNQ30302
Leucine-Rich Repeat-Containing Protein 332 3     

External Ids:    HGNC: 246131   Entrez Gene: 3753872   Ensembl: ENSG000001740047   OMIM: 6153225   UniProtKB: Q86YC33   

Export aliases for NRROS gene to outside databases

Previous GC identifer: GC03P196371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NRROS Gene:
NRROS (negative regulator of reactive oxygen species) is a protein-coding gene. An important paralog of this gene is LRRC32.

UniProtKB/Swiss-Prot: NRROS_HUMAN, Q86YC3
Function: May play a critical role in desensitizing TLR signaling through inhibition of Toll-like
receptor-mediated NF-kappa-B activation and cytokine production




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NRROS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRROS promoter sequence
   Search Chromatin IP Primers for NRROS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRROS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

NRROS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRROS gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P196374:  view genomic region     (about GC identifiers)

Start:
196,366,557 bp from pter      End:
196,388,875 bp from pter
Size:
22,319 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NRROS_HUMAN, Q86YC3 (See protein sequence)
Recommended Name: Negative regulator of reactive oxygen species precursor  
Size: 692 amino acids; 76366 Da
Subunit: Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors

Explore the universe of human proteins at neXtProt for NRROS: NX_Q86YC3

Explore proteomics data for NRROS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys350, Lys576
  • Glycosylation2 at Asn21, Asn74, Asn155, Asn232, Asn292, Asn309, Asn312, Asn408, Asn427, Asn500,
                                 Asn622
  • Modification sites at PhosphoSitePlus

  • See NRROS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940967.1  
    ENSEMBL proteins: 
     ENSP00000328625  

    NRROS Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for NRROS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q86YC3

    ProtoNet protein and cluster: Q86YC3

    UniProtKB/Swiss-Prot: NRROS_HUMAN, Q86YC3
    Similarity: Contains 21 LRR (leucine-rich) repeats


    Find genes that share domains with NRROS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRROS_HUMAN, Q86YC3
    Function: May play a critical role in desensitizing TLR signaling through inhibition of Toll-like
    receptor-mediated NF-kappa-B activation and cytokine production

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NRROS           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for NRROS:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased cell number and incr 

         1 MGI phenotypic allele for Lrrc33 (no phenotypes)

    Find genes that share phenotypes with NRROS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nrrostm1Lex for NRROS

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRROS
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    SwitchGear 3'UTR luciferase reporter plasmidNRROS 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRROS_HUMAN, Q86YC3: Cell membrane; Single-pass type I membrane protein

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NRROS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRROS
    Interactions:

        Search GeneGlobe Interaction Network for NRROS

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NRROS (ENSP000003286254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045087innate immune response IEA--

    Find genes that share ontologies with NRROS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRROS



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NRROS gene: 
    NM_198565.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328557(uc003fwv.3) ENST00000461791
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidNRROS 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NRROS
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    Selected AceView cDNA sequences (see all 122):

    BE673281 AA448292 AW193851 AL133913 BM694954 BM709023 BQ130655 BG105919 
    BI760115 BP432100 BU732488 AA132190 BU159626 BM564927 CR619710 AI810352 
    AK000529 AW299992 BM694867 BU731672 BE326876 CB529905 BC022542 BC044233 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRROS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NRROS Expression
    About this image


    NRROS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    NRROS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRROS Protein Expression

    UniProtKB/Swiss-Prot: NRROS_HUMAN, Q86YC3
    Tissue specificity: Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine
    and spleen

        Custom PCR Arrays for NRROS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRROS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NRROS gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc335
    Nrros1
    leucine rich repeat containing 335
    negative regulator of reactive oxygen species1
    82.32(n)1
    80.78(a)1
      16 (22.40 cM)5
    2241091  NM_146069.41  NP_666181.21 
     321427855 
    chicken
    (Gallus gallus)
    Aves LRRC331 leucine rich repeat containing 33 63.35(n)
    54.68(a)
      424857  XM_004936996.1  XP_004937053.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRROS6
    negative regulator of reactive oxygen species
    52(a)
    1 ↔ 1
    3(30776395-30782895)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nrros1 negative regulator of reactive oxygen species 50.2(n)
    44.96(a)
      100498580  NM_001244986.1  NP_001231915.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nrros1 negative regulator of reactive oxygen species 47.67(n)
    39.72(a)
      445318  NM_001003775.2  NP_001003775.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51956
    --
    12(a)
    1 → many
    3L(20447790-20457962)
    worm
    (Caenorhabditis elegans)
    Secernentea lron-156
    Protein LRON-15 (lron-15) mRNA, complete cds
    12(a)
    1 → many
    II(6540217-6544892) WBGene00016974


    ENSEMBL Gene Tree for NRROS (if available)
    TreeFam Gene Tree for NRROS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRROS gene
    LRRC322  
    1 SIMAP similar gene for NRROS using alignment to 1 protein entry:     NRROS_HUMAN:
    LRRC32

    Find genes that share paralogs with NRROS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRROS (see all 724)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs632560621,2
    C--196220351(+) GAGAC-/GATGAGG 1 -- us2k10--------
    rs1846171721,2
    --196220365(+) GTGGGC/TGGATC 1 -- us2k10--------
    rs1421895271,2
    --196220417(+) GAAATC/TCCATC 1 -- us2k10--------
    rs1882956631,2
    --196220527(+) CAGAGG/TTTGCA 1 -- us2k10--------
    rs1140808431,2
    C,F--196220630(+) GTTATG/TGTGAC 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs800803441,2
    C,F--196220725(+) TAGAAA/GTTAAA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs9860111,2
    C,F,A,H--196220748(+) ccaacT/Agattg 1 -- us2k1 tfbs313Minor allele frequency- A:0.20MN EA NS NA WA CSA 852
    rs1809777641,2
    --196220829(+) TTTGCA/CACAAT 1 -- us2k10--------
    rs1842096111,2
    --196220928(+) AAGACA/GGAGTC 1 -- us2k10--------
    rs1463319581,2
    --196220965(+) AATGGC/TGTGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NRROS (196366557 - 196388875 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NRROS: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRROS
    DNA2.0 Custom Variant and Variant Library Synthesis for NRROS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615322    OMIM disorders: --


    Find genes that share disorders with NRROS           About GenesLikeMe


    Export disorders for NRROS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRROS gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NRROS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-I_B activation. (PubMed id 23545260)1, 2 Liu J....Yang R. (Biochem. Biophys. Res. Commun. 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375387 HGNC: 24613 AceView: FLJ20522andUNQ3030 Ensembl:ENSG00000174004 euGenes: HUgn375387
    ECgene: NRROS H-InvDB: NRROS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRROS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRROS gene:
    Search GeneIP for patents involving NRROS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Custom PCR Arrays for NRROS Search Chromatin IP Primers for NRROS
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     Browse ESI BIO Cell Lines and PureStem Progenitors for NRROS
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     Search Addgene for plasmids for NRROS
      Search eBioscience for proteins for NRROS
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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