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Aliases for NRROS Gene

Aliases for NRROS Gene

  • Negative Regulator Of Reactive Oxygen Species 2 3 5
  • Leucine-Rich Repeat-Containing Protein 33 3 4
  • LRRC33 3 4
  • Leucine Rich Repeat Containing 33 2
  • ELLP3030 3
  • UNQ3030 3
  • GARPL1 3

External Ids for NRROS Gene

Previous HGNC Symbols for NRROS Gene

  • LRRC33

Previous GeneCards Identifiers for NRROS Gene

  • GC03P196371
  • GC03P196374

Summaries for NRROS Gene

GeneCards Summary for NRROS Gene

NRROS (Negative Regulator Of Reactive Oxygen Species) is a Protein Coding gene. An important paralog of this gene is LRRC32.

UniProtKB/Swiss-Prot for NRROS Gene

  • Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRROS Gene

Genomics for NRROS Gene

Regulatory Elements for NRROS Gene

Enhancers for NRROS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G196619 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17 -19.1 -19086 3.2 PKNOX1 FOXA2 ATF1 MLX ARID4B FOS ZNF263 SP5 MXD4 JUNB NRROS LINC01063 TCTEX1D2 SENP5 PCYT1A RNF168 WDR53
GH03G196622 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.9 -15.3 -15309 4.0 PKNOX1 TBL1XR1 ZBTB40 CBX5 RELB ETV6 IKZF2 CREM CBFB JUNB NRROS LINC01063 TCTEX1D2 SENP5 WDR53
GH03G196611 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.5 -27.5 -27497 2.0 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A YY1 ELK1 GATA2 FOS LINC01063 NRROS CEP19 WDR53
GH03G196629 1.6 Ensembl ENCODE dbSUPER 14.2 -7.2 -7196 6.2 HDGF PKNOX1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 CBX5 ZNF143 NRROS CEP19 LINC01063 TCTEX1D2 SDHAP1 WDR53
GH03G196638 1.7 FANTOM5 ENCODE dbSUPER 13.2 +3.1 3093 8.5 HDGF PKNOX1 ATF1 CREB3L1 ARNT WRNIP1 SIN3A GLI4 YY1 ZNF121 NRROS LINC00969 MUC4 SENP5 ENSG00000249626 RNF168 PCYT1A UBXN7 PIGX GC03M196709
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRROS on UCSC Golden Path with GeneCards custom track

Promoters for NRROS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000164442 604 2201 HDGF ATF1 CREB3L1 ARNT WRNIP1 GLI4 ZNF121 ZNF143 ZNF207 FOS

Genomic Location for NRROS Gene

Chromosome:
3
Start:
196,639,686 bp from pter
End:
196,662,004 bp from pter
Size:
22,319 bases
Orientation:
Plus strand

Genomic View for NRROS Gene

Genes around NRROS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRROS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRROS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRROS Gene

Proteins for NRROS Gene

  • Protein details for NRROS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YC3-NRROS_HUMAN
    Recommended name:
    Negative regulator of reactive oxygen species
    Protein Accession:
    Q86YC3

    Protein attributes for NRROS Gene

    Size:
    692 amino acids
    Molecular mass:
    76366 Da
    Quaternary structure:
    • Interacts with CYBB/NOX2; the interaction is direct (By similarity). Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors.

neXtProt entry for NRROS Gene

Post-translational modifications for NRROS Gene

  • Ubiquitination at posLast=350350 and posLast=576576
  • Glycosylation at posLast=2121, posLast=7474, Asn155, Asn232, Asn292, Asn309, Asn312, Asn408, Asn427, Asn500, and posLast=622622
  • Modification sites at PhosphoSitePlus

Other Protein References for NRROS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRROS Gene

Domains & Families for NRROS Gene

Protein Domains for NRROS Gene

Suggested Antigen Peptide Sequences for NRROS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRROS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NRROS Gene

Function for NRROS Gene

Molecular function for NRROS Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.
genes like me logo Genes that share phenotypes with NRROS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NRROS

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRROS Gene

Localization for NRROS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRROS Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRROS gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
extracellular 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NRROS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NRROS: view

Pathways & Interactions for NRROS Gene

SuperPathways for NRROS Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRROS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process ISS,IEA --
GO:0006954 inflammatory response ISS --
GO:0006955 immune response ISS,IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with NRROS: view

No data available for Pathways by source and SIGNOR curated interactions for NRROS Gene

Drugs & Compounds for NRROS Gene

No Compound Related Data Available

Transcripts for NRROS Gene

mRNA/cDNA for NRROS Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRROS Gene

No ASD Table

Relevant External Links for NRROS Gene

GeneLoc Exon Structure for
NRROS
ECgene alternative splicing isoforms for
NRROS

Expression for NRROS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRROS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRROS Gene

This gene is overexpressed in Whole Blood (x7.5) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for NRROS Gene

This gene is overexpressed in Cervix (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRROS Gene



Protein tissue co-expression partners for NRROS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRROS Gene:

NRROS

mRNA Expression by UniProt/SwissProt for NRROS Gene:

Q86YC3-NRROS_HUMAN
Tissue specificity: Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen.
genes like me logo Genes that share expression patterns with NRROS: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRROS Gene

Orthologs for NRROS Gene

This gene was present in the common ancestor of animals.

Orthologs for NRROS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRROS 35
  • 97 (a)
OneToOne
LRRC33 34
  • 95.71 (n)
cow
(Bos Taurus)
Mammalia NRROS 34
  • 84.44 (n)
LRRC33 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrros 34
  • 82.56 (n)
mouse
(Mus musculus)
Mammalia Nrros 34 16 35
  • 82.32 (n)
dog
(Canis familiaris)
Mammalia NRROS 34 35
  • 74.01 (n)
oppossum
(Monodelphis domestica)
Mammalia NRROS 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRROS 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC33 34
  • 63.35 (n)
NRROS 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRROS 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrros 34
  • 50.2 (n)
zebrafish
(Danio rerio)
Actinopterygii nrros 34 35
  • 47.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5195 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-15 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
ManyToMany
Species where no ortholog for NRROS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRROS Gene

ENSEMBL:
Gene Tree for NRROS (if available)
TreeFam:
Gene Tree for NRROS (if available)

Paralogs for NRROS Gene

Paralogs for NRROS Gene

(1) SIMAP similar genes for NRROS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NRROS: view

Variants for NRROS Gene

Sequence variations from dbSNP and Humsavar for NRROS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000012951 -- 196,647,514(+) TTCAA(A/T)ATATA intron-variant
rs1000070804 -- 196,662,470(+) GTAAT(C/T)CCAGC downstream-variant-500B
rs1000173897 -- 196,644,698(+) AACCC(C/T)GGAGG intron-variant
rs1000211817 -- 196,648,869(+) CACCC(C/T)CAGCC intron-variant
rs1000250213 -- 196,658,865(+) CTCGG(A/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRROS Gene

Variant ID Type Subtype PubMed ID
nsv1003066 CNV gain 25217958
nsv1003135 CNV gain 25217958
nsv1014526 CNV gain 25217958
nsv1014692 CNV gain 25217958
nsv829828 CNV loss 17160897

Variation tolerance for NRROS Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRROS Gene

Human Gene Mutation Database (HGMD)
NRROS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRROS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRROS Gene

Disorders for NRROS Gene

Relevant External Links for NRROS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRROS

No disorders were found for NRROS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRROS Gene

Publications for NRROS Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-I_B activation. (PMID: 23545260) Liu J. … Yang R. (Biochem. Biophys. Res. Commun. 2013) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. (PMID: 24550525) Su X. … Yang R. (J. Leukoc. Biol. 2014) 3 64
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3 64

Products for NRROS Gene

Sources for NRROS Gene

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