Aliases for NRROS Gene
External Ids for NRROS Gene
Previous Symbols for NRROS Gene
GeneCards Summary for NRROS Gene
NRROS (Negative Regulator Of Reactive Oxygen Species) is a Protein Coding gene. An important paralog of this gene is LRRC32.
UniProtKB/Swiss-Prot for NRROS Gene
Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.