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Aliases for NRROS Gene

Aliases for NRROS Gene

  • Negative Regulator Of Reactive Oxygen Species 2 3
  • LRRC33 3 4 6
  • Leucine-Rich Repeat-Containing Protein 33 3 4
  • Leucine Rich Repeat Containing 33 2
  • ELLP3030 3
  • UNQ3030 3
  • GARPL1 3

External Ids for NRROS Gene

Previous HGNC Symbols for NRROS Gene

  • LRRC33

Previous GeneCards Identifiers for NRROS Gene

  • GC03P196371
  • GC03P196374

Summaries for NRROS Gene

GeneCards Summary for NRROS Gene

NRROS (Negative Regulator Of Reactive Oxygen Species) is a Protein Coding gene. An important paralog of this gene is LRRC32.

UniProtKB/Swiss-Prot for NRROS Gene

  • Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRROS Gene

Genomics for NRROS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NRROS Gene

Start:
196,639,686 bp from pter
End:
196,662,004 bp from pter
Size:
22,319 bases
Orientation:
Plus strand

Genomic View for NRROS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRROS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRROS Gene

No data available for Regulatory Elements for NRROS Gene

Proteins for NRROS Gene

  • Protein details for NRROS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YC3-NRROS_HUMAN
    Recommended name:
    Negative regulator of reactive oxygen species
    Protein Accession:
    Q86YC3
    Secondary Accessions:

    Protein attributes for NRROS Gene

    Size:
    692 amino acids
    Molecular mass:
    76366 Da
    Quaternary structure:
    • Interacts with CYBB/NOX2; the interaction is direct (By similarity). Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors.

neXtProt entry for NRROS Gene

Proteomics data for NRROS Gene at MOPED

Post-translational modifications for NRROS Gene

  • Ubiquitination at Lys350 and Lys576
  • Glycosylation at Asn21, Asn74, Asn155, Asn232, Asn292, Asn309, Asn312, Asn408, Asn427, Asn500, and Asn622
  • Modification sites at PhosphoSitePlus

Other Protein References for NRROS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRROS Gene

Domains for NRROS Gene

Protein Domains for NRROS Gene

Graphical View of Domain Structure for InterPro Entry

Q86YC3

UniProtKB/Swiss-Prot:

NRROS_HUMAN :
  • Q86YC3
Similarity:
  • Contains 21 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NRROS: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NRROS Gene

Function for NRROS Gene

Molecular function for NRROS Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.

Gene Ontology (GO) - Molecular Function for NRROS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NRROS: view
genes like me logo Genes that share phenotypes with NRROS: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRROS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NRROS Gene

Localization for NRROS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRROS Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for NRROS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NRROS: view

No data available for Subcellular locations from COMPARTMENTS for NRROS Gene

Pathways for NRROS Gene

SuperPathways for NRROS Gene

No Data Available

Interacting Proteins for NRROS Gene

Gene Ontology (GO) - Biological Process for NRROS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process ISS --
GO:0006954 inflammatory response ISS --
GO:0006955 immune response ISS --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with NRROS: view

No data available for Pathways by source for NRROS Gene

Transcripts for NRROS Gene

mRNA/cDNA for NRROS Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRROS

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRROS Gene

No ASD Table

Relevant External Links for NRROS Gene

GeneLoc Exon Structure for
NRROS
ECgene alternative splicing isoforms for
NRROS

Expression for NRROS Gene

mRNA expression in normal human tissues for NRROS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRROS Gene

This gene is overexpressed in Whole Blood (7.5) and Spleen (4.3).

Protein differential expression in normal tissues for NRROS Gene

This gene is overexpressed in Cervix (65.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NRROS Gene

mRNA Expression by UniProt/SwissProt for NRROS Gene

Q86YC3-NRROS_HUMAN
Tissue specificity: Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen.
genes like me logo Genes that share expressions with NRROS: view

Expression partners for NRROS Gene

In Situ Assay Products

Orthologs for NRROS Gene

This gene was present in the common ancestor of animals.

Orthologs for NRROS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRROS 35
  • 84.44 (n)
  • 82.08 (a)
LRRC33 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRROS 35
  • 74.01 (n)
  • 68.32 (a)
NRROS 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrros 35
  • 82.32 (n)
  • 80.78 (a)
Lrrc33 16
Nrros 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC33 35
  • 95.71 (n)
  • 94.8 (a)
NRROS 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrros 35
  • 82.56 (n)
  • 79.77 (a)
oppossum
(Monodelphis domestica)
Mammalia NRROS 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRROS 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC33 35
  • 63.35 (n)
  • 54.68 (a)
NRROS 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRROS 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrros 35
  • 50.2 (n)
  • 44.96 (a)
zebrafish
(Danio rerio)
Actinopterygii nrros 35
  • 47.67 (n)
  • 39.72 (a)
nrros 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5195 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-15 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
ManyToMany
Species with no ortholog for NRROS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRROS Gene

ENSEMBL:
Gene Tree for NRROS (if available)
TreeFam:
Gene Tree for NRROS (if available)

Paralogs for NRROS Gene

Paralogs for NRROS Gene

Selected SIMAP similar genes for NRROS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NRROS: view

Variants for NRROS Gene

Sequence variations from dbSNP and Humsavar for NRROS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs843516 -- 196,651,766(+) cgtct(C/T)aaaaa intron-variant
rs843517 -- 196,651,834(+) tcagc(A/G)gaaga intron-variant
rs843518 -- 196,652,348(+) TTACT(C/T)GCTAC intron-variant
rs843519 -- 196,652,866(+) GTGGC(C/G)AGGGA intron-variant
rs843520 -- 196,653,045(+) AGTGG(C/T)GGTGA intron-variant

Relevant External Links for NRROS Gene

HapMap Linkage Disequilibrium report
NRROS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NRROS Gene

Disorders for NRROS Gene

No disorders were found for NRROS Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NRROS Gene

Publications for NRROS Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-I_B activation. (PMID: 23545260) Liu J. … Yang R. (Biochem. Biophys. Res. Commun. 2013) 3 4
  4. Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. (PMID: 24550525) Su X. … Yang R. (J. Leukoc. Biol. 2014) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NRROS Gene

Sources for NRROS Gene

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