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Aliases for NRROS Gene

Aliases for NRROS Gene

  • Negative Regulator Of Reactive Oxygen Species 2 3 5
  • Leucine-Rich Repeat-Containing Protein 33 3 4
  • LRRC33 3 4
  • Leucine Rich Repeat Containing 33 2
  • ELLP3030 3
  • UNQ3030 3
  • GARPL1 3

External Ids for NRROS Gene

Previous HGNC Symbols for NRROS Gene

  • LRRC33

Previous GeneCards Identifiers for NRROS Gene

  • GC03P196371
  • GC03P196374

Summaries for NRROS Gene

GeneCards Summary for NRROS Gene

NRROS (Negative Regulator Of Reactive Oxygen Species) is a Protein Coding gene. An important paralog of this gene is LRRC32.

UniProtKB/Swiss-Prot for NRROS Gene

  • Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRROS Gene

Genomics for NRROS Gene

Regulatory Elements for NRROS Gene

Enhancers for NRROS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NRROS on UCSC Golden Path with GeneCards custom track

Promoters for NRROS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRROS on UCSC Golden Path with GeneCards custom track

Genomic Location for NRROS Gene

Chromosome:
3
Start:
196,639,686 bp from pter
End:
196,662,004 bp from pter
Size:
22,319 bases
Orientation:
Plus strand

Genomic View for NRROS Gene

Genes around NRROS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRROS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRROS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRROS Gene

Proteins for NRROS Gene

  • Protein details for NRROS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YC3-NRROS_HUMAN
    Recommended name:
    Negative regulator of reactive oxygen species
    Protein Accession:
    Q86YC3

    Protein attributes for NRROS Gene

    Size:
    692 amino acids
    Molecular mass:
    76366 Da
    Quaternary structure:
    • Interacts with CYBB/NOX2; the interaction is direct (By similarity). Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors.

neXtProt entry for NRROS Gene

Proteomics data for NRROS Gene at MOPED

Post-translational modifications for NRROS Gene

  • Ubiquitination at Lys 350 and Lys 576
  • Glycosylation at Asn 21, Asn 74, Asn 155, Asn 232, Asn 292, Asn 309, Asn 312, Asn 408, Asn 427, Asn 500, and Asn 622
  • Modification sites at PhosphoSitePlus

Other Protein References for NRROS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRROS Gene

Domains & Families for NRROS Gene

Protein Domains for NRROS Gene

Suggested Antigen Peptide Sequences for NRROS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YC3

UniProtKB/Swiss-Prot:

NRROS_HUMAN :
  • Contains 21 LRR (leucine-rich) repeats.
Similarity:
  • Contains 21 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NRROS: view

No data available for Gene Families for NRROS Gene

Function for NRROS Gene

Molecular function for NRROS Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.
genes like me logo Genes that share phenotypes with NRROS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NRROS

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRROS Gene

Localization for NRROS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRROS Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for NRROS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with NRROS: view

No data available for Subcellular locations from COMPARTMENTS for NRROS Gene

Pathways & Interactions for NRROS Gene

SuperPathways for NRROS Gene

No Data Available

Interacting Proteins for NRROS Gene

Gene Ontology (GO) - Biological Process for NRROS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process IEA,ISS --
genes like me logo Genes that share ontologies with NRROS: view

No data available for Pathways by source and SIGNOR curated interactions for NRROS Gene

Drugs & Compounds for NRROS Gene

No Compound Related Data Available

Transcripts for NRROS Gene

mRNA/cDNA for NRROS Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NRROS Gene

No ASD Table

Relevant External Links for NRROS Gene

GeneLoc Exon Structure for
NRROS
ECgene alternative splicing isoforms for
NRROS

Expression for NRROS Gene

mRNA expression in normal human tissues for NRROS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRROS Gene

This gene is overexpressed in Whole Blood (x7.5) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for NRROS Gene

This gene is overexpressed in Cervix (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRROS Gene



mRNA Expression by UniProt/SwissProt for NRROS Gene

Q86YC3-NRROS_HUMAN
Tissue specificity: Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen.
genes like me logo Genes that share expression patterns with NRROS: view

Protein tissue co-expression partners for NRROS Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NRROS Gene

This gene was present in the common ancestor of animals.

Orthologs for NRROS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRROS 35
  • 84.44 (n)
  • 82.08 (a)
LRRC33 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRROS 35
  • 74.01 (n)
  • 68.32 (a)
NRROS 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrros 35
  • 82.32 (n)
  • 80.78 (a)
Nrros 16
Nrros 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC33 35
  • 95.71 (n)
  • 94.8 (a)
NRROS 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrros 35
  • 82.56 (n)
  • 79.77 (a)
oppossum
(Monodelphis domestica)
Mammalia NRROS 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRROS 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC33 35
  • 63.35 (n)
  • 54.68 (a)
NRROS 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRROS 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrros 35
  • 50.2 (n)
  • 44.96 (a)
zebrafish
(Danio rerio)
Actinopterygii nrros 35
  • 47.67 (n)
  • 39.72 (a)
nrros 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5195 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-15 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
ManyToMany
Species with no ortholog for NRROS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRROS Gene

ENSEMBL:
Gene Tree for NRROS (if available)
TreeFam:
Gene Tree for NRROS (if available)

Paralogs for NRROS Gene

Paralogs for NRROS Gene

(1) SIMAP similar genes for NRROS Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NRROS: view

Variants for NRROS Gene

Sequence variations from dbSNP and Humsavar for NRROS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1099215 -- 196,658,627(+) CTGAT(A/G)AACTT intron-variant
rs1872354 -- 196,653,571(+) TGGGG(A/G)CATGC intron-variant
rs1872355 -- 196,653,922(+) TCTTC(A/T)TTTTC intron-variant
rs1212534 -- 196,647,285(+) GAAAA(A/C)GTGTG intron-variant
rs2340532 -- 196,655,056(-) tttca(C/T)catgt intron-variant

Variation tolerance for NRROS Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRROS Gene

HapMap Linkage Disequilibrium report
NRROS
Human Gene Mutation Database (HGMD)
NRROS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NRROS Gene

Disorders for NRROS Gene

Relevant External Links for NRROS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRROS

No disorders were found for NRROS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRROS Gene

Publications for NRROS Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. (PMID: 24550525) Su X. … Yang R. (J. Leukoc. Biol. 2014) 3
  3. Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-I_B activation. (PMID: 23545260) Liu J. … Yang R. (Biochem. Biophys. Res. Commun. 2013) 3
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for NRROS Gene

Sources for NRROS Gene

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