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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NRP2 Gene

protein-coding GIFtS: 64
GCID: GC02P206510

neuropilin 2

Explore 39 diseases affiliated with
NRP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neuropilin 2¹ ²		Neuropilin-2¹
VEGF165R2¹ ² ³		Neuropilin-2a(17)¹
Vascular Endothelial Cell Growth Factor 165 Receptor 2² ³		Neuropilin-2a(22)¹
NPN2² ⁵		Neuropilin-2b(0)¹
NP2²		Receptor For VEGF165 And Semaphorins Class3²
PRO2714²		VEGF1265R2⁵

External Ids:	HGNC: 8005¹	Entrez Gene: 8828²	Ensembl: ENSG00000118257⁷	OMIM: 602070⁵	UniProtKB: O60462³

Export aliases for NRP2 gene to outside databases

Previous GC identifers: GC02P204763 GC02P205271 GC02P206749 GC02P206372 GC02P206254 GC02P198397

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NRP2:

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to

SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F

protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with

vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance,

and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NRP2_HUMAN, O60462

Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform

of PGF

Gene Wiki entry for NRP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NRP2 gene promoter:
USF1 USF-1:USF-2 Cdc5 MEF-2A CREB PPAR-gamma1 USF-1 Msx-1 PPAR-gamma2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NRP2 promoter sequence

Search SABiosciences Chromatin IP Primers for NRP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q33.3

NRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRP2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P206510: view genomic region (about GC identifiers)

Start:	206,546,714 bp from pter	End:	206,662,857 bp from pter
Size:	116,144 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NRP2_HUMAN, O60462 (See protein sequence)

Recommended Name: Neuropilin-2 precursor

Size: 931 amino acids; 104859 Da

Subunit: Heterodimer with NRP1. Binds PLXNB1

Subcellular location: Membrane; Single-pass type I membrane protein

Subcellular location: Isoform s9: Secreted

4 PDB 3D structures from and Proteopedia for NRP2:

2QQJ (3D)

2QQK (3D)

2QQL (3D)

2QQO (3D)

Secondary accessions: E9PF66 O14820 O14821 Q53TQ4 Q53TS3 Q7LBX7 Q9H2D4 Q9H2D5 Q9H2E2 Q9H2E3 Q9H2E4

Alternative splicing: 6 isoforms: O60462-1 O60462-2 O60462-3 O60462-4 O60462-5 O60462-6

Explore the universe of human proteins at neXtProt for NRP2: NX_O60462

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60462

NRP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_003863.2 NP_061004.3 NP_957716.1 NP_957718.1 NP_957719.1 NP_958436.1

ENSEMBL proteins:

ENSP00000353582 ENSP00000404279 ENSP00000387519 ENSP00000349632 ENSP00000350432

ENSP00000407626 ENSP00000272849 ENSP00000439658 ENSP00000439261 ENSP00000347238

Reactome Protein details: O60462
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NRP2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002116	semaphorin receptor complex	NAS	19909241
GO:0005576	extracellular region	IEA	--
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	TAS	9288754

NRP2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NRP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NRP2 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR000859 CUB_dom

IPR000998 MAM_dom

IPR014648 Neuropilin

IPR022579 Neuropilin1_C

IPR000421 Coagulation_fac_5/8-C_type_dom

Graphical View of Domain Structure for InterPro Entry O60462

ProtoNet protein and cluster: O60462

3 Blocks protein families:

IPB000421 Coagulation factor 5/8 type C domain (FA58C)

IPB000859 CUB domain

IPB000998 MAM domain signature

UniProtKB/Swiss-Prot: NRP2_HUMAN, O60462

Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin

and VEGF binding

Similarity: Belongs to the neuropilin family

Similarity: Contains 2 CUB domains

Similarity: Contains 2 F5/8 type C domains

Similarity: Contains 1 MAM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NRP2_HUMAN, O60462

Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform

of PGF

Genatlas biochemistry entry for NRP2:

neuropilin 2,cell surface glycoprotein expressed by the developing nervous system,semaphorin 3C and 3F

receptor,implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial

growth factor-165 receptor

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		8/132 QIAGEN miScript miRNA Assays for microRNAs that regulate NRP2 (see all 132):
		hsa-miR-146a hsa-miR-106a hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-877* hsa-miR-149 hsa-miR-200b

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Gene Editing
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		GenScript: all cDNA clones in your preferred vector (see all 6): NRP2 (NM_003872)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRP2

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	9288754
GO:0005021	vascular endothelial growth factor-activated receptor activity	NAS	19909241
GO:0005515	protein binding	--	--
GO:0008201	heparin binding	IEA	--
GO:0017154	semaphorin receptor activity	NAS	19909241

NRP2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NRP2:

Decreased focal adhesion (FA)

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out Nrp2^tm1Ddg for NRP2
15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Nrp2) (see all 16):

behavior/neurological	cardiovascular system	cellular	craniofacial	embryogenesis
growth/size	homeostasis/metabolism	immune system	integument	mortality/aging
muscle	nervous system	no phenotypic analysis	reproductive system	respiratory system

NRP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/12 pathways (see all 12)
Apoptotic Pathways in Synovial Fibroblasts	1.00	Cellular Apoptosis Pathway	0.65
p53 Mediated Apoptosis	0.84	ERK5 Signaling	0.61
Mitochondrial Apoptosis	0.73	eIF2 Pathway	0.60
Telomerase Components in Cell Signaling	0.72	Rac1 Pathway	0.58

Signaling by VEGF

	Signaling by VEGF	1.00			Neurophilin interactions with VEGF and VEGFR	0.36
	VEGF ligand-receptor interactions	1.00

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NRP2

Development VEGF-family signaling

5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NRP2 (see all 23)

	MAPK Signaling
	Nuclear Receptor Activation by Vitamin-A
	DHA Signaling
	Actin-Based Motility by Rho Family GTPases
	Telomerase Components in Cell Signaling

2 Cell Signaling Technology (CST) Pathways for NRP2

	Angiogenesis
	Neuroscience

1 GeneGo (Thomson Reuters) Pathway for NRP2

Development VEGF-family signaling

2 BioSystems Pathways for NRP2

	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2

5/8 Reactome Pathways for NRP2 (see all 8)

	L1CAM interactions
	Developmental Biology
	Signaling by VEGF
	VEGF ligand-receptor interactions
	NrCAM interactions

NRP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NRP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/23 Interacting proteins for NRP2 (O60462³ ENSP00000353582⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PGF	P49763³, ENSP00000238607⁴	I2D: score=3 STRING: ENSP00000238607
SEMA3F	Q13275³, ENSP00000002829⁴	I2D: score=3 STRING: ENSP00000002829
FLT1	P17948³, ENSP00000282397⁴	I2D: score=2 STRING: ENSP00000282397
RYK	P34925³, ENSP00000296084⁴	I2D: score=1 STRING: ENSP00000296084
PLXNA1	Q9UIW2³, ENSP00000251772⁴	I2D: score=1 STRING: ENSP00000251772

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	NAS	11112349
GO:0001755	neural crest cell migration	IEA	--
GO:0001938	positive regulation of endothelial cell proliferation	TAS	--
GO:0007155	cell adhesion	NAS	11112349
GO:0007411	axon guidance	TAS	--

NRP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NRP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NRP2
3 Novoseek chemical compound relationships for NRP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	80.6	89	12845630 (5), 19918856 (4), 19409892 (3), 14871832 (2) (see all 46)
tyrosine	15.1	2	18680722 (1), 15655556 (1)
heparin	0	3	10748121 (2), 11394892 (1)

1 PharmGKB related drug/compound annotation for NRP2 gene

Drug/compound	PharmGKB Annotation
daunorubicin	CA

About this table

Search CenterWatch for drugs/clinical trials and news about NRP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NRP2 gene (6 alternative transcripts):

NM_003872.2 NM_018534.3 NM_201264.1 NM_201266.1 NM_201267.1 NM_201279.1

Unigene Cluster for NRP2:

Neuropilin 2

Hs.471200 [show with all ESTs]

Unigene Representative Sequence: AL833606

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000464003 ENST00000360409(uc002vaw.3 uc002vax.3 uc002vay.3)

ENST00000450507 ENST00000417189(uc010fud.3) ENST00000478013 ENST00000357118(uc002vau.3 uc002vav.3)

ENST00000357785 ENST00000412873 ENST00000272849 ENST00000483917 ENST00000477199

ENST00000478054 ENST00000460987 ENST00000468256 ENST00000485684 ENST00000472299

ENST00000467850 ENST00000540178

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		8/132 QIAGEN miScript miRNA Assays for microRNAs that regulate NRP2 (see all 132):
		hsa-miR-146a hsa-miR-106a hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-877* hsa-miR-149 hsa-miR-200b

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Additional cDNA sequence:

AF016098.1 AF022859.1 AF022860.1 AF280544.1 AF280545.1 AF280546.1 AK130198.1 AK290934.1

AK307367.1 AK307616.1 AL833606.1 BC009222.2 BC018631.1 BC101525.1 BC104770.1 BC117413.1

BC143237.1 BC143238.1 BC143608.1 BX537423.1

22 DOTS entries:

DT.75167264 DT.100789324 DT.40110815 DT.92436824 DT.100789325 DT.100789326 DT.92021211 DT.95083064

DT.92436822 DT.117986 DT.95097071 DT.102842919 DT.75132949 DT.97844725 DT.40110814 DT.70104222

DT.409302 DT.95219751 DT.100715088 DT.75147934 DT.91950198 DT.91937575

24/424 AceView cDNA sequences (see all 424):

AI078546 AI139975 BM694688 N29077 AI129223 BM719658 AW468722 AI351435

AW294130 CD518840 AA464594 BM680412 BE549811 AA233301 NM_201264 BF058123

AI241539 AI468518 CK821132 AI692777 NM_018534 AI378498 CA976157 AI919413

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NRP2 (see all 11) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^	18	^
SP1:															-						-												-						-
SP2:															-						-												-
SP3:					-		-								-
SP4:			-		-		-
SP5:

ExUns:	19a	·	19b	^	20a	·	20b	^	21	^	22	^	23
SP1:			-		-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for NRP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NRP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGACAAGA

About this image

NRP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Cardinal Veins

Venous Endothelial Cells

Selective marker (cell-identifying gene)

Endothelium

Lateral Plate Mesoderm

Embryonic Capillary Plexus

Angioblasts

Endothelium

Lateral Plate Mesoderm

Proepicardium

Angioblasts

Endothelium

Bone

Autopod Perichondrium

Endochondral Preosteoblasts

Bone

Cervical Vertebrae

Endochondral Preosteoblasts

Bone

Lumbar Vertebrae

Endochondral Preosteoblasts

Bone

Sacral Vertebrae

Endochondral Preosteoblasts

Bone

Stylopod Perichondrium

Endochondral Preosteoblasts

Bone

Thoracic Rib

Endochondral Preosteoblasts

Bone

Thoracic Vertebrae

Endochondral Preosteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

Definitive endoderm-like cells (A scalable, suspensi...)

See NRP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NRP2

SOURCE GeneReport for Unigene cluster: Hs.471200

SABiosciences Expression via Pathway-Focused PCR Arrays including NRP2:

Neurogenesis in human mouse rat

Terminal Differentiation Markers in human mouse rat

VEGF Signaling in human mouse rat

Angiogenesis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NRP2 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NRP2¹	neuropilin 2	75.54(n) 77.26(a)		374157 NM_204284.1 NP_989615.1
lizard (Anolis carolinensis)	Reptilia	NRP2⁶	--	77(a)	1 ↔ 1	GL343208.1(953474-1096536)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.14279²	Transcribed sequence with moderate similarity to protein more	80.1(n)		137715912
zebrafish (Danio rerio)	Actinopterygii	AY437404.1²	--	76.02(n)		AY437404.1

ENSEMBL Gene Tree for NRP2 (if available)
TreeFam Gene Tree for NRP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NRP2 gene

DCBLD1² EDIL3² MFGE8² DCBLD2² NRP1² RS1²

18/29 SIMAP similar genes for NRP2 using alignment to 7 protein entries: NRP2_HUMAN (see all proteins) (see all similar genes):

DKFZp686J1169 F8C DKFZp686A03134 NRP1 CSMD3 DKFZp781F1414

DMBT1 TLL2 RS1 SPAG10 TLL1 DDR1

PCOLCE BMP1 C1S CUBN SEZ6 DDR2

NRP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143954561^1,2	C,F	other	198508074(+)	`TACACC/TCTGGA`	6	T	syn¹		1		NA	4550
rs5837989^1,2	C,	--	198394064(+)	`AGGAGA/-AATGT`	6	--	us2k¹ tfbs³ trp³		2		NA	4
rs80179364^1,2	F,	--	198394309(+)	`AATCCC/TGCGCC`	6	--	us2k¹		1		WA	118
rs73983213^1,2	C,	--	198394353(+)	`AATCAC/TTTCTG`	6	--	us2k¹		2		WA	120
rs114945472^1,2	C,F,	--	198394470(+)	`NNNNAA/GCCACC`	6	--	us2k¹		1		NA	120
rs67827769^1,2	C	--	198395405(+)	`CCAAGG/-GCGGC`	6	--	us2k¹		1		NA	2
rs113185080^1,2		--	198396045(+)	`CTTCCA/GCTCGG`	6	--	ut5¹		2		CSA WA	119
rs10164557^1,2	C,	--	198397211(+)	`TGCTGA/GCAACC`	6	--	int¹		0	--	--	--	--
rs72939353^1,2	C,F,	--	198397448(+)	`GGGGAC/TCGCAT`	6	--	int¹		3		WA NA EA	358
rs7563993^1,2	C,	--	198397839(+)	`CACACC/GACTTT`	6	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for NRP2 (206546714 - 206662857 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NRP2
1 CNV: 68225
Human Gene Mutation Database (HGMD): NRP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NRP2 for disorders           About GeneDecksing

OMIM gene information: 602070    OMIM disorders: --

20/39 diseases for NRP2 (see all 39):    About MalaCards

malignant pleural mesothelioma wallerian degeneration adenoid cystic carcinoma malignant mesothelioma

adenoiditis malignant glioma lymphedema neuroendocrine tumor

rheumatoid arthritis colon cancer hemangioma neurofibromatosis

skin disease myeloid leukemia breast cancer ovarian carcinoma

carcinoma pancreatitis pancreatic carcinoma arthritis

10/12 Novoseek disease relationships for NRP2 gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	42.9	1	12412174 (1)
tumors	38.1	21	18182619 (4), 16445911 (3), 17010410 (1), 19409892 (1) (see all 11)
metastasis	29.4	23	19580679 (6), 19197975 (1), 16445911 (1), 19240167 (1) (see all 6)
glioma	21	1	15160992 (1)
cancer lung	12.6	3	12845630 (1), 15967098 (1)
cancer	8.07	6	19580679 (2), 19409892 (1), 18182619 (1), 14760080 (1)
adenocarcinoma	4.97	3	20041133 (1), 15476280 (1)
colon cancer	0	2	16391856 (1), 16928828 (1)
breast cancer	0	6	19580679 (4), 15802023 (1)
nsclc	0	4	12412174 (4)

Human Genome Epidemiology (HuGE) Navigator: NRP2 (6 documents)

Export disorders for NRP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NRP2 gene, integrated from 9 sources (see all 154):
(articles sorted by number of sources associating them with NRP2)

Utopia: connect your pdf to the dynamic
world of online information

Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PubMed id 9331348)^{1, 2, 3, 9} Chen H.... Tessier-Lavigne M. (1997)
Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF. (PubMed id 10748121)^{1, 2, 9} Gluzman-Poltorak Z.... Neufeld G. (2000)
Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (PubMed id 11112349)^{1, 2, 9} Rossignol M.... Klagsbrun M. (2000)
Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PubMed id 10520995)^{1, 2} Tamagnone L.... Comoglio P.M. (1999)
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. (PubMed id 9529250)^{2, 3} Soker S.... Klagsbrun M. (1998)
Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression . (PubMed id 19580679)^{1, 9} Yasuoka H....Nakamura Y. (2009)
Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephropathies and cytokine-stimulated proximal tubul ar cells. (PubMed id 19736548)^{1, 9} Schramek H....Mayer G. (2009)
Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. (PubMed id 18182619)^{1, 9} Gray M.J....Ellis L.M. (2008)
Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. (PubMed id 17427189)^{1, 9} Wu S....Zhang D. (2007)
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. (PubMed id 16816121)^{1, 9} Karpanen T....Alitalo K. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8828	HGNC: 8005	AceView: NRP2	Ensembl:ENSG00000118257	euGenes: HUgn8828
ECgene: NRP2	H-InvDB: NRP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NRP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NRP2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NRP2 gene
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Patent Information for NRP2 gene:
Search GeneIP for patents involving NRP2

GeneCards and IP:
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neuropilin 2

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