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Aliases for NRP2 Gene

Aliases for NRP2 Gene

  • Neuropilin 2 2 3 5
  • Vascular Endothelial Cell Growth Factor 165 Receptor 2 3 4
  • VEGF165R2 3 4
  • Receptor For VEGF165 And Semaphorins Class3 3
  • Neuropilin-2a(17) 3
  • Neuropilin-2a(22) 3
  • Neuropilin-2b(0) 3
  • Neuropilin-2 3
  • PRO2714 3
  • NPN2 3
  • NP2 3

External Ids for NRP2 Gene

Previous GeneCards Identifiers for NRP2 Gene

  • GC02P204763
  • GC02P205271
  • GC02P206510
  • GC02P206749
  • GC02P206372
  • GC02P206254
  • GC02P198397

Summaries for NRP2 Gene

Entrez Gene Summary for NRP2 Gene

  • This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRP2 Gene

NRP2 (Neuropilin 2) is a Protein Coding gene. Diseases associated with NRP2 include Wallerian Degeneration and Lymphedema. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include receptor activity and growth factor binding. An important paralog of this gene is NRP1.

UniProtKB/Swiss-Prot for NRP2 Gene

  • High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Gene Wiki entry for NRP2 Gene

Additional gene information for NRP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRP2 Gene

Genomics for NRP2 Gene

Regulatory Elements for NRP2 Gene

Enhancers for NRP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H205705 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17 +25.5 25497 4 HDGF PKNOX1 TBL1XR1 RB1 SIN3A BMI1 BATF ZNF143 ZNF207 ATF7 NRP2 ENSG00000225216 INO80D GC02P205736
GH02H205711 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +31.6 31574 4 BATF ZNF143 FOS RUNX3 IKZF2 CREM SMARCA5 JUNB ELF1 ZNF623 NRP2 ENSG00000225216 INO80D GC02P205736
GH02H205678 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14 -2.3 -2293 3 PKNOX1 ZFP64 FEZF1 ZNF2 RAD21 ETS1 ZNF366 ZSCAN5C ZNF143 ZNF391 NRP2 GC02P205616
GH02H205729 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +50.6 50616 5 FOXA2 BACH1 ZNF316 POLR2A FOS NFE2 MAFK NFE2L2 EZH2 FOXA3 ENSG00000225216 NRP2 ADAM23 GC02P205736
GH02H205753 1.2 Ensembl ENCODE dbSUPER 15.3 +74.6 74602 5 ESRRA JUN CEBPB THRB NR2F2 RARA ZFHX2 JUND GATA3 FOS NRP2 GC02P205747 ENSG00000225216
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRP2 Gene

Chromosome:
2
Start:
205,681,990 bp from pter
End:
205,798,133 bp from pter
Size:
116,144 bases
Orientation:
Plus strand

Genomic View for NRP2 Gene

Genes around NRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRP2 Gene

Proteins for NRP2 Gene

  • Protein details for NRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60462-NRP2_HUMAN
    Recommended name:
    Neuropilin-2
    Protein Accession:
    O60462
    Secondary Accessions:
    • E9PF66
    • O14820
    • O14821
    • Q53TQ4
    • Q53TS3
    • Q7LBX7
    • Q9H2D4
    • Q9H2D5
    • Q9H2E2
    • Q9H2E3
    • Q9H2E4

    Protein attributes for NRP2 Gene

    Size:
    931 amino acids
    Molecular mass:
    104859 Da
    Quaternary structure:
    • Heterodimer with NRP1. Binds PLXNB1.

    Three dimensional structures from OCA and Proteopedia for NRP2 Gene

    Alternative splice isoforms for NRP2 Gene

neXtProt entry for NRP2 Gene

Post-translational modifications for NRP2 Gene

  • Glycosylation at posLast=152152, posLast=157157, Thr607, posLast=629629, Ser672, and Asn839
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NRP2 (NRP2)

No data available for DME Specific Peptides for NRP2 Gene

Domains & Families for NRP2 Gene

Gene Families for NRP2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

O60462

UniProtKB/Swiss-Prot:

NRP2_HUMAN :
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
  • Belongs to the neuropilin family.
Domain:
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Family:
  • Belongs to the neuropilin family.
genes like me logo Genes that share domains with NRP2: view

Function for NRP2 Gene

Molecular function for NRP2 Gene

GENATLAS Biochemistry:
neuropilin 2,cell surface glycoprotein expressed by the developing nervous system,semaphorin 3C and 3F receptor,implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor
UniProtKB/Swiss-Prot Function:
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Phenotypes From GWAS Catalog for NRP2 Gene

Gene Ontology (GO) - Molecular Function for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9288754
GO:0005021 vascular endothelial growth factor-activated receptor activity IEA,NAS 11112349
GO:0008201 heparin binding IEA --
GO:0017154 semaphorin receptor activity NAS,IEA 11112349
GO:0019838 growth factor binding TAS 21245381
genes like me logo Genes that share ontologies with NRP2: view
genes like me logo Genes that share phenotypes with NRP2: view

Animal Models for NRP2 Gene

MGI Knock Outs for NRP2:

Animal Model Products

CRISPR Products

miRNA for NRP2 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRP2 Gene

Localization for NRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRP2 Gene

Membrane; Single-pass type I membrane protein.
Isoform s9: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRP2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
peroxisome 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex NAS 19909241
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS,IEA 9288754
GO:0016021 integral component of membrane IEA,NAS 11112349
genes like me logo Genes that share ontologies with NRP2: view

Pathways & Interactions for NRP2 Gene

genes like me logo Genes that share pathways with NRP2: view

SIGNOR curated interactions for NRP2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 11112349
GO:0001755 neural crest cell migration IEA --
GO:0001764 neuron migration IEA --
GO:0001938 positive regulation of endothelial cell proliferation TAS 21245381
GO:0003148 outflow tract septum morphogenesis ISS --
genes like me logo Genes that share ontologies with NRP2: view

Drugs & Compounds for NRP2 Gene

(3) Drugs for NRP2 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daunorubicin Approved Pharma DNA topoisomerase II inhibitor 284

(1) Additional Compounds for NRP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRP2: view

Transcripts for NRP2 Gene

Unigene Clusters for NRP2 Gene

Neuropilin 2:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NRP2 Gene

GeneLoc Exon Structure for
NRP2
ECgene alternative splicing isoforms for
NRP2

Expression for NRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRP2 Gene

This gene is overexpressed in Esophagus - Muscularis (x4.6), Colon - Sigmoid (x4.3), and Esophagus - Gastroesophageal Junction (x4.2).

Protein differential expression in normal tissues from HIPED for NRP2 Gene

This gene is overexpressed in Serum (28.7) and Uterus (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of NRP2 Gene:

NRP2

SOURCE GeneReport for Unigene cluster for NRP2 Gene:

Hs.471200

Evidence on tissue expression from TISSUES for NRP2 Gene

  • Nervous system(4.7)
  • Lung(2.8)
  • Skin(2.6)
  • Eye(2.5)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with NRP2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRP2 Gene

Orthologs for NRP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRP2 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia NRP2 33 34
  • 91.37 (n)
cow
(Bos Taurus)
Mammalia NRP2 33 34
  • 90.82 (n)
mouse
(Mus musculus)
Mammalia Nrp2 33 16 34
  • 89.01 (n)
rat
(Rattus norvegicus)
Mammalia Nrp2 33
  • 87.93 (n)
oppossum
(Monodelphis domestica)
Mammalia NRP2 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRP2 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRP2 33 34
  • 75.69 (n)
lizard
(Anolis carolinensis)
Reptilia NRP2 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrp2 33
  • 70.72 (n)
Str.14279 33
zebrafish
(Danio rerio)
Actinopterygii nrp2b 33 34
  • 64.65 (n)
nrp2a 34
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5393 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7396 34
  • 22 (a)
OneToMany
Species where no ortholog for NRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRP2 Gene

ENSEMBL:
Gene Tree for NRP2 (if available)
TreeFam:
Gene Tree for NRP2 (if available)

Paralogs for NRP2 Gene

Variants for NRP2 Gene

Sequence variations from dbSNP and Humsavar for NRP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs200483574 Benign 205,776,521(+) GCACT(-/A)GCTGA intron-variant, downstream-variant-500B, reference, frameshift-variant
rs1000014176 -- 205,752,934(+) GACCA(C/T)CTGGG nc-transcript-variant, reference, missense
rs1000070137 -- 205,794,601(+) GGATG(C/T)GGCCA intron-variant
rs1000087072 -- 205,752,623(+) CACTG(A/G)CAGAC intron-variant
rs1000101832 -- 205,721,917(+) GCTCC(C/T)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRP2 Gene

Variant ID Type Subtype PubMed ID
esv25775 CNV gain 19812545
nsv3123 CNV insertion 18451855
nsv460021 CNV gain 19166990
nsv524370 CNV loss 19592680
nsv526779 CNV loss 19592680
nsv584246 CNV gain 21841781
nsv834514 CNV gain 17160897

Variation tolerance for NRP2 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRP2 Gene

Human Gene Mutation Database (HGMD)
NRP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP2 Gene

Disorders for NRP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NRP2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
lymphedema
  • lymphatic edema
- elite association - COSMIC cancer census association via MalaCards
Search NRP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRP2

Genetic Association Database (GAD)
NRP2
Human Genome Epidemiology (HuGE) Navigator
NRP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRP2
genes like me logo Genes that share disorders with NRP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRP2 Gene

Publications for NRP2 Gene

  1. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PMID: 9331348) Chen H … Tessier-Lavigne M (Neuron 1997) 2 3 4 22 60
  2. Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. (PMID: 17427189) Wu S … Zhang D (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 45 60
  3. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (PMID: 11112349) Rossignol M … Klagsbrun M (Genomics 2000) 3 4 22 60
  4. Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]. (PMID: 10748121) Gluzman-Poltorak Z … Neufeld G (The Journal of biological chemistry 2000) 3 4 22 60
  5. Neuropilin-2 acts as a modulator of Sema3A-dependent glioma cell migration. (PMID: 19855168) Nasarre C … Bagnard D (Cell adhesion & migration 2009) 3 22 60

Products for NRP2 Gene

Sources for NRP2 Gene

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