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Aliases for NRP2 Gene

Aliases for NRP2 Gene

  • Neuropilin 2 2 3
  • Vascular Endothelial Cell Growth Factor 165 Receptor 2 3 4
  • VEGF165R2 3 4
  • NPN2 3 6
  • Receptor For VEGF165 And Semaphorins Class3 3
  • Neuropilin-2a(17) 3
  • Neuropilin-2a(22) 3
  • Neuropilin-2b(0) 3
  • Neuropilin-2 3
  • VEGF1265R2 6
  • PRO2714 3
  • NP2 3

External Ids for NRP2 Gene

Previous GeneCards Identifiers for NRP2 Gene

  • GC02P204763
  • GC02P205271
  • GC02P206510
  • GC02P206749
  • GC02P206372
  • GC02P206254
  • GC02P198397

Summaries for NRP2 Gene

Entrez Gene Summary for NRP2 Gene

  • This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRP2 Gene

NRP2 (Neuropilin 2) is a Protein Coding gene. Diseases associated with NRP2 include wallerian degeneration and infantile epileptic encephalopathy. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include receptor activity and growth factor binding. An important paralog of this gene is F5.

UniProtKB/Swiss-Prot for NRP2 Gene

  • High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF

Gene Wiki entry for NRP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRP2 Gene

Genomics for NRP2 Gene

Regulatory Elements for NRP2 Gene

Genomic Location for NRP2 Gene

Start:
205,681,990 bp from pter
End:
205,798,133 bp from pter
Size:
116,144 bases
Orientation:
Plus strand

Genomic View for NRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRP2 Gene

Proteins for NRP2 Gene

  • Protein details for NRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60462-NRP2_HUMAN
    Recommended name:
    Neuropilin-2
    Protein Accession:
    O60462
    Secondary Accessions:
    • E9PF66
    • O14820
    • O14821
    • Q53TQ4
    • Q53TS3
    • Q7LBX7
    • Q9H2D4
    • Q9H2D5
    • Q9H2E2
    • Q9H2E3
    • Q9H2E4

    Protein attributes for NRP2 Gene

    Size:
    931 amino acids
    Molecular mass:
    104859 Da
    Quaternary structure:
    • Heterodimer with NRP1. Binds PLXNB1.

    Three dimensional structures from OCA and Proteopedia for NRP2 Gene

    Alternative splice isoforms for NRP2 Gene

neXtProt entry for NRP2 Gene

Proteomics data for NRP2 Gene at MOPED

Post-translational modifications for NRP2 Gene

  • Glycosylation at Asn152, Asn157, Thr595, Thr600, Thr603, Thr607, Asn629, Ser672, and Asn839
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRP2 Gene

Domains for NRP2 Gene

Graphical View of Domain Structure for InterPro Entry

O60462

UniProtKB/Swiss-Prot:

NRP2_HUMAN :
  • O60462
Domain:
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding
  • Contains 2 CUB domains.
  • Contains 2 F5/8 type C domains.
  • Contains 1 MAM domain.
Family:
  • Belongs to the neuropilin family.
genes like me logo Genes that share domains with NRP2: view

No data available for Gene Families for NRP2 Gene

Function for NRP2 Gene

Molecular function for NRP2 Gene

GENATLAS Biochemistry: neuropilin 2,cell surface glycoprotein expressed by the developing nervous system,semaphorin 3C and 3F receptor,implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor
UniProtKB/Swiss-Prot Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF

Gene Ontology (GO) - Molecular Function for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9288754
GO:0005021 vascular endothelial growth factor-activated receptor activity NAS 11112349
GO:0005515 protein binding --
GO:0008201 heparin binding IEA --
GO:0017154 semaphorin receptor activity NAS 11112349
genes like me logo Genes that share ontologies with NRP2: view
genes like me logo Genes that share phenotypes with NRP2: view

Animal Models for NRP2 Gene

MGI Knock Outs for NRP2:

miRNA for NRP2 Gene

miRTarBase miRNAs that target NRP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NRP2 Gene

Localization for NRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRP2 Gene

Membrane; Single-pass type I membrane protein.
Isoform s9: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRP2 Gene COMPARTMENTS Subcellular localization image for NRP2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex NAS 19909241
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 9288754
GO:0016021 integral component of membrane NAS 11112349
genes like me logo Genes that share ontologies with NRP2: view

Pathways for NRP2 Gene

genes like me logo Genes that share pathways with NRP2: view

Pathways by source for NRP2 Gene

1 Sino Biological pathway for NRP2 Gene
2 Cell Signaling Technology pathways for NRP2 Gene
1 GeneGo (Thomson Reuters) pathway for NRP2 Gene
1 R&D Systems pathway for NRP2 Gene

Gene Ontology (GO) - Biological Process for NRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 11112349
GO:0001755 neural crest cell migration --
GO:0001764 neuron migration --
GO:0001938 positive regulation of endothelial cell proliferation TAS 21245381
GO:0007155 cell adhesion NAS 11112349
genes like me logo Genes that share ontologies with NRP2: view

Compounds for NRP2 Gene

(3) Novoseek inferred chemical compound relationships for NRP2 Gene

Compound -log(P) Hits PubMed IDs
vegf 80.6 61
tyrosine 15.1 2
heparin 0 3

(1) PharmGKB related drug/compound annotations for NRP2 Gene

Drug/compound Annotation
daunorubicin CA
genes like me logo Genes that share compounds with NRP2: view

Transcripts for NRP2 Gene

Unigene Clusters for NRP2 Gene

Neuropilin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRP2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NRP2 Gene

GeneLoc Exon Structure for
NRP2
ECgene alternative splicing isoforms for
NRP2

Expression for NRP2 Gene

mRNA expression in normal human tissues for NRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRP2 Gene

This gene is overexpressed in Esophagus - Muscularis (4.6), Colon - Sigmoid (4.3), and Esophagus - Gastroesophageal Junction (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRP2 Gene

SOURCE GeneReport for Unigene cluster for NRP2 Gene Hs.471200

genes like me logo Genes that share expressions with NRP2: view

No data available for mRNA Expression by UniProt/SwissProt for NRP2 Gene

Orthologs for NRP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRP2 35
  • 99.42 (n)
  • 99.68 (a)
NRP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRP2 35
  • 90.82 (n)
  • 96.44 (a)
NRP2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRP2 35
  • 91.37 (n)
  • 96.67 (a)
NRP2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrp2 35
  • 89.01 (n)
  • 94.52 (a)
Nrp2 16
Nrp2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRP2 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrp2 35
  • 87.93 (n)
  • 93.73 (a)
chicken
(Gallus gallus)
Aves NRP2 35
  • 75.69 (n)
  • 77.56 (a)
NRP2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRP2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrp2 35
  • 70.72 (n)
  • 72.18 (a)
Str.14279 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5393 35
zebrafish
(Danio rerio)
Actinopterygii nrp2a 36
  • 55 (a)
OneToMany
nrp2b 35
  • 64.65 (n)
  • 61.56 (a)
nrp2b 36
  • 59 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7396 36
  • 22 (a)
OneToMany
Species with no ortholog for NRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRP2 Gene

ENSEMBL:
Gene Tree for NRP2 (if available)
TreeFam:
Gene Tree for NRP2 (if available)

Paralogs for NRP2 Gene

Paralogs for NRP2 Gene

genes like me logo Genes that share paralogs with NRP2: view

Variants for NRP2 Gene

Sequence variations from dbSNP and Humsavar for NRP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9706 -- 205,797,619(+) CTGTC(A/G)TAAGA utr-variant-3-prime
rs10090 -- 205,682,821(-) GACAC(A/G)CGGGC utr-variant-5-prime, intron-variant
rs10773 -- 205,797,612(+) GGCTG(C/G)TCTGT utr-variant-3-prime
rs15994 -- 205,797,573(+) GTACG(C/G)AGGGC utr-variant-3-prime
rs698909 -- 205,689,820(+) CGAAT(A/G)TGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRP2 Gene

Variant ID Type Subtype PubMed ID
esv25775 CNV Gain 19812545
nsv834514 CNV Gain 17160897
nsv460021 CNV Gain 19166990
nsv875732 CNV Gain 21882294
nsv3123 CNV Insertion 18451855
nsv526779 CNV Loss 19592680
nsv524370 CNV Loss 19592680
nsv875733 CNV Gain 21882294

Relevant External Links for NRP2 Gene

HapMap Linkage Disequilibrium report
NRP2
Human Gene Mutation Database (HGMD)
NRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP2 Gene

Disorders for NRP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NRP2 Gene including...

Search for NRP2 Gene in MalaCards »

(12) Novoseek inferred disease relationships for NRP2 Gene

Disease -log(P) Hits PubMed IDs
neovascularization 42.9 1
tumors 38.1 16
metastasis 29.4 11
glioma 21 1
cancer lung 12.6 2

Relevant External Links for NRP2

Genetic Association Database (GAD)
NRP2
Human Genome Epidemiology (HuGE) Navigator
NRP2
genes like me logo Genes that share disorders with NRP2: view

No data available for UniProtKB/Swiss-Prot for NRP2 Gene

Publications for NRP2 Gene

  1. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PMID: 9331348) Chen H. … Tessier-Lavigne M. (Neuron 1997) 2 3 4 23
  2. Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF. (PMID: 10748121) Gluzman-Poltorak Z. … Neufeld G. (J. Biol. Chem. 2000) 3 4 23
  3. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (PMID: 11112349) Rossignol M. … Klagsbrun M. (Genomics 2000) 3 4 23
  4. Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. (PMID: 17427189) Wu S. … Zhang D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48
  5. Neuroendocrine cells along the digestive tract express neuropilin-2. (PMID: 11394892) Cohen T. … Neufeld G. (Biochem. Biophys. Res. Commun. 2001) 3 23

Products for NRP2 Gene

Sources for NRP2 Gene

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