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NRP2 Gene

protein-coding   GIFtS: 67
GCID: GC02P206510

Neuropilin 2

  See NRP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropilin 21 2     neuropilin-22
Vascular Endothelial Cell Growth Factor 165 Receptor 22 3     neuropilin-2a(17)2
VEGF165R22 3     neuropilin-2a(22)2
NPN22 5     neuropilin-2b(0)2
NP22     Receptor For VEGF165 And Semaphorins Class32
PRO27142     VEGF1265R25

External Ids:    HGNC: 80051   Entrez Gene: 88282   Ensembl: ENSG000001182577   OMIM: 6020705   UniProtKB: O604623   

Export aliases for NRP2 gene to outside databases

Previous GC identifers: GC02P204763 GC02P205271 GC02P206749 GC02P206372 GC02P206254 GC02P198397


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRP2 Gene:
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds
to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and
SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and
interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular
development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been
identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NRP2 Gene:
NRP2 (neuropilin 2) is a protein-coding gene. Diseases associated with NRP2 include wallerian degeneration, and infantile epileptic encephalopathy. GO annotations related to this gene include growth factor binding and receptor activity. An important paralog of this gene is DCBLD1.

UniProtKB/Swiss-Prot: NRP2_HUMAN, O60462
Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2
isoform of PGF

Gene Wiki entry for NRP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRP2 gene promoter:
         USF1   USF-1:USF-2   Cdc5   MEF-2A   CREB   PPAR-gamma1   USF-1   Msx-1   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRP2 promoter sequence
   Search Chromatin IP Primers for NRP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.3   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q33.3

NRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P206510:  view genomic region     (about GC identifiers)

Start:
206,546,714 bp from pter      End:
206,662,857 bp from pter
Size:
116,144 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NRP2_HUMAN, O60462 (See protein sequence)
Recommended Name: Neuropilin-2 precursor  
Size: 931 amino acids; 104859 Da
Subunit: Heterodimer with NRP1. Binds PLXNB1
4 PDB 3D structures from and Proteopedia for NRP2:
2QQJ (3D)        2QQK (3D)        2QQL (3D)        2QQO (3D)    
Secondary accessions: E9PF66 O14820 O14821 Q53TQ4 Q53TS3 Q7LBX7 Q9H2D4 Q9H2D5 Q9H2E2 Q9H2E3
Q9H2E4
Alternative splicing: 6 isoforms:  O60462-1   O60462-2   O60462-3   O60462-4   O60462-5   O60462-6   

Explore the universe of human proteins at neXtProt for NRP2: NX_O60462

Explore proteomics data for NRP2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn152, Asn157, Thr595, Thr600, Thr603, Thr607, Asn629, Ser672, Asn839
  • Modification sites at PhosphoSitePlus

  • See NRP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_003863.2  NP_061004.3  NP_957716.1  NP_957718.1  NP_957719.1  NP_958436.1  

    ENSEMBL proteins: 
     ENSP00000353582   ENSP00000404279   ENSP00000387519   ENSP00000349632   ENSP00000350432  
     ENSP00000272849   ENSP00000407626   ENSP00000439658   ENSP00000439261   ENSP00000347238  
    Reactome Protein details: O60462

    NRP2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NRP2
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    Novus Biologicals NRP2 Proteins
    Novus Biologicals NRP2 Lysates
    Sino Biological Recombinant Protein for NRP2
    Sino Biological Cell Lysate for NRP2
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    Cloud-Clone Corp. Proteins for NRP2

     
    Search eBioscience for Proteins for NRP2 

     
    antibodies-online proteins for NRP2 (5 products) 

     
    antibodies-online peptides for NRP2

    NRP2 Antibody Products:

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    antibodies-online antibodies for NRP2 (46 products) 

    NRP2 Assay Products:

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    Cloud-Clone Corp. ELISAs for NRP2
    Cloud-Clone Corp. CLIAs for NRP2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000859 CUB_dom
     IPR000998 MAM_dom
     IPR014648 Neuropilin
     IPR022579 Neuropilin1_C
     IPR000421 Coagulation_fac_5/8-C_type_dom

    Graphical View of Domain Structure for InterPro Entry O60462

    ProtoNet protein and cluster: O60462

    3 Blocks protein domains:
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB000859 CUB domain
    IPB000998 MAM domain signature


    UniProtKB/Swiss-Prot: NRP2_HUMAN, O60462
    Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for
    heparin and VEGF binding
    Similarity: Belongs to the neuropilin family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 2 F5/8 type C domains
    Similarity: Contains 1 MAM domain


    Find genes that share domains with NRP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRP2_HUMAN, O60462
    Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2
    isoform of PGF

         Genatlas biochemistry entry for NRP2:
    neuropilin 2,cell surface glycoprotein expressed by the developing nervous system,semaphorin 3C and 3F
    receptor,implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial
    growth factor-165 receptor

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9288754
    GO:0005021vascular endothelial growth factor-activated receptor activity NAS11112349
    GO:0005515protein binding ----
    GO:0008201heparin binding IEA--
    GO:0017154semaphorin receptor activity NAS11112349
         
    Find genes that share ontologies with NRP2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NRP2:
     Decreased focal adhesion (FA)   Increased HPV18 LCR reporter a 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Nrp2) (see all 16):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  nervous system  no phenotypic analysis  reproductive system  respiratory system 

    Find genes that share phenotypes with NRP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nrp2tm1Ddg for NRP2

       genOway: Develop your customized and physiologically relevant rodent model for NRP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NRP2:
    hsa-mir-331-3p (MIRT019236), hsa-mir-335-5p (MIRT017537), hsa-mir-10b-5p (MIRT025587)

    Block miRNA regulation of human, mouse, rat NRP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRP2 (see all 132):
    hsa-miR-146a hsa-miR-106a hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-877* hsa-miR-149 hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NRP2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 6): NRP2 (NM_003872)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRP2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRP2_HUMAN, O60462: Membrane; Single-pass type I membrane protein
    NRP2_HUMAN, O60462: Isoform s9: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    peroxisome2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002116semaphorin receptor complex NAS19909241
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS9288754
    GO:0016021integral component of membrane NAS11112349

    Find genes that share ontologies with NRP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NRP2 About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    PPAR Pathway0.66
    Cellular Apoptosis Pathway0.85
    Rac1 Pathway0.65
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    NrCAM interactions0.00
    3Signaling by VEGF
    Signaling by VEGF
    VEGF ligand-receptor interactions0.00
    Neurophilin interactions with VEGF and VEGFR0.00
    4CREB Pathway
    CREB Pathway0.68
    Activation of PKC through GPCR0.63
    5p70S6K Signaling
    p70S6K Signaling0.60
    Renin-Angiotensin Pathway0.60


    Find genes that share SuperPaths with NRP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NRP2
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NRP2 (see all 23)
        MAPK Signaling
    Nuclear Receptor Activation by Vitamin-A
    DHA Signaling
    Actin-Based Motility by Rho Family GTPases
    Telomerase Components in Cell Signaling

    2 Cell Signaling Technology (CST) Pathways for NRP2
        Angiogenesis
    Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for NRP2
        Development VEGF-family signaling

    2 BioSystems Pathways for NRP2
        VEGFR1 specific signals
    Signaling events mediated by VEGFR1 and VEGFR2

    1 Sino Biological Pathway for NRP2
        VEGF Signaling

    2 Reactome Pathways for NRP2
        NrCAM interactions
    Neurophilin interactions with VEGF and VEGFR


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRP2: 
              Neurogenesis in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              VEGF Signaling in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NRP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NRP2 (O604623 ENSP000003535824) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PGFP497633, ENSP000002386074I2D: score=3 STRING: ENSP00000238607
    SEMA3FQ132753, ENSP000000028294I2D: score=3 STRING: ENSP00000002829
    FLT1P179483, ENSP000002823974I2D: score=2 STRING: ENSP00000282397
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    NRP1O147863, ENSP000002653714I2D: score=1 STRING: ENSP00000265371
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis NAS11112349
    GO:0001755neural crest cell migration IEA--
    GO:0001938positive regulation of endothelial cell proliferation TAS--
    GO:0007155cell adhesion NAS11112349
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with NRP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRP2

    3 Novoseek inferred chemical compound relationships for NRP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 80.6 89 12845630 (5), 19918856 (4), 19409892 (3), 14871832 (2) (see all 46)
    tyrosine 15.1 2 18680722 (1), 15655556 (1)
    heparin 0 3 10748121 (2), 11394892 (1)

    1 PharmGKB related drug/compound annotation for NRP2 gene    About this table
    Drug/compound PharmGKB Annotation
    daunorubicinCA  



    Find genes that share compounds with NRP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NRP2 gene (6 alternative transcripts): 
    NM_003872.2  NM_018534.3  NM_201264.1  NM_201266.1  NM_201267.1  NM_201279.1  

    Unigene Cluster for NRP2:

    Neuropilin 2
    Hs.471200  [show with all ESTs]
    Unigene Representative Sequence: AL833606
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000464003 ENST00000360409(uc002vaw.3 uc002vax.3 uc002vay.3)
    ENST00000450507 ENST00000417189(uc010fud.3) ENST00000478013 ENST00000357118(uc002vau.3 uc002vav.3)
    ENST00000357785 ENST00000272849 ENST00000412873 ENST00000483917 ENST00000477199
    ENST00000478054 ENST00000460987 ENST00000468256 ENST00000485684 ENST00000472299
    ENST00000467850 ENST00000540178
    miRNA
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    hsa-miR-146a hsa-miR-106a hsa-miR-128 hsa-miR-342-3p hsa-miR-519a hsa-miR-877* hsa-miR-149 hsa-miR-200b
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      QuantiFast Probe-based Assays in human, mouse, rat NRP2

    Additional mRNA sequence: 

    AF016098.1 AF022859.1 AF022860.1 AF280544.1 AF280545.1 AF280546.1 AK130198.1 AK290934.1 
    AK307367.1 AK307616.1 AL833606.1 BC009222.2 BC018631.1 BC101525.1 BC104770.1 BC117413.1 
    BC143237.1 BC143238.1 BC143608.1 BX537423.1 

    22 DOTS entries:

    DT.75167264  DT.100789324  DT.40110815  DT.92436824  DT.100789325  DT.100789326  DT.92021211  DT.95083064 
    DT.92436822  DT.117986  DT.95097071  DT.102842919  DT.75132949  DT.97844725  DT.40110814  DT.70104222 
    DT.409302  DT.95219751  DT.100715088  DT.75147934  DT.91950198  DT.91937575 

    Selected AceView cDNA sequences (see all 424):

    AI150714 BF732653 BM694688 AI468518 AI784594 N29077 CB053557 AI139975 
    CA976157 BE549811 AA047241 AU132493 CD518840 N44559 AI718749 BU729653 
    AA233301 AI282185 AA463866 BI793012 T35750 AI078546 CA444100 BE504942 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NRP2 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                            -                 -                                   -                 -                                       
    SP2:                                            -                 -                                   -                                                         
    SP3:              -     -                       -                                                                                                               
    SP4:        -     -     -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
    SP1:        -     -                           
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for NRP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGACAAGA
    NRP2 Expression
    About this image


    NRP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 6 entries
             Angioblasts Embryonic Capillary Plexus
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Angioblasts Embryonic Capillary Plexus
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 5 entries
             Cardiac Neural Crest Cells Cardiac Neural Crest
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Venous Endothelial Cells Cardinal Veins
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
    NRP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471200
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRP2: 
              Neurogenesis in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              VEGF Signaling in human mouse rat
              Angiogenesis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NRP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrp21 , 5 neuropilin 21, 5 89.01(n)1
    94.52(a)1
      1 (31.35 cM)5
    181871  NM_001077403.11  NP_001070871.11 
     627032855 
    chicken
    (Gallus gallus)
    Aves NRP21 neuropilin 2 75.69(n)
    77.56(a)
      374157  NM_204284.1  NP_989615.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRP26
    neuropilin 2
    76(a)
    1 ↔ 1
    GL343208.1(948566-1237279)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.142792 Transcribed sequence with moderate similarity to protein more 80.1(n)    137715912 
    zebrafish
    (Danio rerio)
    Actinopterygii AY437404.12   -- 76.02(n)    AY437404.1 


    ENSEMBL Gene Tree for NRP2 (if available)
    TreeFam Gene Tree for NRP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRP2 gene
    DCBLD12  EDIL32  MFGE82  DCBLD22  F82  NRP12  RS12  F52  
    Selected SIMAP similar genes for NRP2 using alignment to 7 protein entries:     NRP2_HUMAN (see all proteins) (see all similar genes):
    DKFZp686J1169    F8C    DKFZp686A03134    NRP1    CSMD3    DKFZp781F1414
    DMBT1    TLL2    RS1    SPAG10    TLL1    DDR1
    PCOLCE    BMP1    C1S    CUBN    SEZ6    DDR2

    Find genes that share paralogs with NRP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRP2 (see all 2385)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439545611,2
    C,Funtested1206050030(+) TACACC/TCTGGA 6 T syn11Minor allele frequency- T:0.00NA 4550
    rs345034311,2
    C--198421924(+) TTCTTC/-GCCTT 6 -- int11Minor allele frequency- -:0.50NA 2
    rs113854571,2
    C--198430461(+) AGCATG/-GTCCT 6 -- int12Minor allele frequency- -:0.25CSA 4
    rs780050531,2
    C--198437405(+) AAAAAA/TATATA 6 -- int10--------
    rs679756621,2
    C--198437906(+) TTTTT-/T/TTT 
            
    TTTTT
    12 -- int1 cds11NA 2
    rs1143153461,2
    F--198461435(+) TAACAT/CTTCCA 5 -- int11Minor allele frequency- C:0.01NA 120
    rs1997151021,2
    C--198511404(-) GCAGAA/GAAAAA 3 -- ds50010--------
    rs1408522031,2
    --205935771(+) ATGGTC/TTGGCA 6 -- us2k10--------
    rs2011370661,2
    --205935852(+) GTTCT-/TTGT  
     CCTTAGA
    TTGTC
    6 -- us2k10--------
    rs102116071,2
    C--205935873(+) CATCTT/CGGCAA 6 -- us2k13Minor allele frequency- C:0.04CSA WA EA 240

    HapMap Linkage Disequilibrium report for NRP2 (206546714 - 206662857 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NRP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3123CNV Insertion18451855
    nsv524370CNV Loss19592680
    nsv526779CNV Loss19592680
    nsv875732CNV Gain21882294
    esv25775CNV Gain19812545
    nsv875733CNV Gain21882294
    nsv460021CNV Gain19166990
    nsv834514CNV Gain17160897

    Human Gene Mutation Database (HGMD): NRP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRP2
    DNA2.0 Custom Variant and Variant Library Synthesis for NRP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602070    OMIM disorders: --

    2 diseases for NRP2:    
    About MalaCards
    wallerian degeneration    infantile epileptic encephalopathy


    Find genes that share disorders with NRP2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NRP2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 42.9 1 12412174 (1)
    tumors 38.1 21 18182619 (4), 16445911 (3), 17010410 (1), 19409892 (1) (see all 11)
    metastasis 29.4 23 19580679 (6), 19197975 (1), 16445911 (1), 19240167 (1) (see all 6)
    glioma 21 1 15160992 (1)
    cancer lung 12.6 3 12845630 (1), 15967098 (1)
    cancer 8.07 6 19580679 (2), 19409892 (1), 18182619 (1), 14760080 (1)
    adenocarcinoma 4.97 3 20041133 (1), 15476280 (1)
    colon cancer 0 2 16391856 (1), 16928828 (1)
    breast cancer 0 6 19580679 (4), 15802023 (1)
    nsclc 0 4 12412174 (4)

    Genetic Association Database (GAD): NRP2
    Human Genome Epidemiology (HuGE) Navigator: NRP2 (6 documents)

    Export disorders for NRP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRP2 gene, integrated from 10 sources (see all 170):
    (articles sorted by number of sources associating them with NRP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PubMed id 9331348)1, 2, 3, 9 Chen H.... Tessier-Lavigne M. (Neuron 1997)
    2. Association of the neuropilin-2 (NRP2) gene polymorphisms with autism in Chinese Han population. (PubMed id 17427189)1, 4, 9 Wu S....Zhang D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    3. Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF. (PubMed id 10748121)1, 2, 9 Gluzman-Poltorak Z.... Neufeld G. (J. Biol. Chem. 2000)
    4. Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms. (PubMed id 11112349)1, 2, 9 Rossignol M.... Klagsbrun M. (Genomics 2000)
    5. Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes. (PubMed id 18785001)1, 4 Schneider B.P....Sledge G.W. (Breast Cancer Res. Treat. 2009)
    6. Candidate gene analysis in primary lymphedema. (PubMed id 18564921)1, 4 Ferrell R.E....Finegold D.N. (Lymphat Res Biol 2008)
    7. Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PubMed id 10520995)1, 2 Tamagnone L.... Comoglio P.M. (Cell 1999)
    8. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. (PubMed id 9529250)2, 3 Soker S.... Klagsbrun M. (Cell 1998)
    9. Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression. (PubMed id 19580679)1, 9 Yasuoka H....Nakamura Y. (BMC Cancer 2009)
    10. Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephropathies and cytokine-stimulated proximal tubular cells. (PubMed id 19736548)1, 9 Schramek H....Mayer G. ( a journal of technical methods and pathology 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8828 HGNC: 8005 AceView: NRP2 Ensembl:ENSG00000118257 euGenes: HUgn8828
    ECgene: NRP2 H-InvDB: NRP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NRP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NRP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRP2 gene:
    Search GeneIP for patents involving NRP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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