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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NRP1 Gene

protein-coding GIFtS: 69
GCID: GC10M033506

neuropilin 1

Explore 94 diseases affiliated with
NRP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neuropilin 1¹ ²		BDCA4²
NRP¹ ² ³ ⁵		NP1²
VEGF165R¹ ² ³ ⁵		Neuropilin-1¹
CD304¹ ²		Transmembrane Receptor²
Vascular Endothelial Cell Growth Factor 165 Receptor² ³		CD304 Antigen³

External Ids:	HGNC: 8004¹	Entrez Gene: 8829²	Ensembl: ENSG00000099250⁷	OMIM: 602069⁵	UniProtKB: O14786³

Export aliases for NRP1 gene to outside databases

Previous GC identifers: GC10M033216 GC10M033616 GC10M033470

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NRP1:

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in

several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal

extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins

also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and

various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and

co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several

alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

(provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786

Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in

angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It

mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The

VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as

increased chemotaxis. It may regulate VEGF-induced angiogenesis

Function: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce

apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an

averse effect on blood vessel number and integrity

Gene Wiki entry for NRP1 (Neuropilin 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NRP1 gene promoter:
CREB MyoD STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NRP1 promoter sequence

Search SABiosciences Chromatin IP Primers for NRP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12 Ensembl cytogenetic band: 10p11.22 HGNC cytogenetic band: 10p12

NRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRP1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M033506: view genomic region (about GC identifiers)

Start:	33,466,419 bp from pter	End:	33,625,190 bp from pter
Size:	158,772 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786 (See protein sequence)

Recommended Name: Neuropilin-1 precursor

Size: 923 amino acids; 103134 Da

Subunit: Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1

Subcellular location: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

6 PDB 3D structures from and Proteopedia for NRP1:

1KEX (3D)

2QQI (3D)

2QQM (3D)

2QQN (3D)

3I97 (3D)

4DEQ (3D)

Secondary accessions: B0LPG9 O60461 Q5T7F2 Q5T7F3 Q86T59 Q96IH5

Alternative splicing: 2 isoforms: O14786-1 O14786-2

Explore the universe of human proteins at neXtProt for NRP1: NX_O14786

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14786

NRP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001019799.1 NP_001019800.1 NP_001231901.1 NP_001231902.1 NP_003864.4

ENSEMBL proteins:

ENSP00000265371 ENSP00000364009 ENSP00000390447 ENSP00000416147 ENSP00000393071

ENSP00000363955 ENSP00000363954 ENSP00000363956 ENSP00000408911 ENSP00000390567

ENSP00000364001 ENSP00000379317 ENSP00000363949

Reactome Protein details: O14786
Human Recombinant Protein Products:

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	Novus Biologicals NRP1 Proteins Novus Biologicals NRP1 Lysates
	Sino Biological Recombinant Protein for NRP1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NRP1

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002116	semaphorin receptor complex	NAS	19909241
GO:0005576	extracellular region	IEA	--
GO:0005829	cytosol	IDA	--
GO:0005883	neurofilament	IEA	--
GO:0005886	plasma membrane	TAS	--

NRP1 for ontologies About GeneDecksing

NRP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NRP1
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	ThermoFisher Antibody for NRP1

Assay Products for NRP1:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NRP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NRP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NRP1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR000859 CUB_dom

IPR000998 MAM_dom

IPR014648 Neuropilin

IPR022579 Neuropilin1_C

IPR000421 Coagulation_fac_5/8-C_type_dom

Graphical View of Domain Structure for InterPro Entry O14786

ProtoNet protein and cluster: O14786

3 Blocks protein families:

IPB000421 Coagulation factor 5/8 type C domain (FA58C)

IPB000859 CUB domain

IPB000998 MAM domain signature

UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786

Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin

and VEGF binding

Similarity: Belongs to the neuropilin family

Similarity: Contains 2 CUB domains

Similarity: Contains 2 F5/8 type C domains

Similarity: Contains 1 MAM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786

Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in

angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It

mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The

VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as

increased chemotaxis. It may regulate VEGF-induced angiogenesis

Function: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce

apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an

averse effect on blood vessel number and integrity

Genatlas biochemistry entry for NRP1:

neuropilin 1,cell surface glycoprotein,expressed by the developing nervous system, complexing with plexin

1(PLXN1),implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial

growth factor-165 receptor,with dominant negative form resulting from the deletion of an extracellular

domain,necessary component of receptor complexes for some,but not all,secreted semaphorin family members

miRNA Products:		miRTarBase miRNAs that target NRP1: hsa-mir-1 (MIRT001352)

		OriGene 3'-UTR Clone: NRP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRP1
		8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate NRP1 (see all 80):
		hsa-miR-3607-3p hsa-miR-361-5p hsa-miR-376b hsa-miR-4272 hsa-miR-200a hsa-miR-1244 hsa-miR-3148 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: NRP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRP1 (see all 7) OriGene shRNA RFP: NRP1 OriGene siRNA: NRP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRP1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for NRP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRP1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRP1 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NRP1 (NM_003873)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRP1

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005021	vascular endothelial growth factor-activated receptor activity	NAS	19909241
GO:0005515	protein binding	IPI	--
GO:0008201	heparin binding	IEA	--
GO:0015026	coreceptor activity	TAS	--
GO:0017154	semaphorin receptor activity	NAS	19909241

NRP1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for NRP1:

Increased peripheral focal adh

Increased resistance to Trastu

Weaker migration

Animal Models:
Mouse knock-outs for NRP1: Nrp1^tm2.1Ddg Nrp1^tm1Hfu
9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Nrp1):

cardiovascular system	cellular	craniofacial	embryogenesis	growth/size
immune system	mortality/aging	nervous system	vision/eye

NRP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/12 pathways (see all 12)
Apoptotic Pathways in Synovial Fibroblasts	1.00	Cellular Apoptosis Pathway	0.65
p53 Mediated Apoptosis	0.84	ERK5 Signaling	0.61
Mitochondrial Apoptosis	0.73	eIF2 Pathway	0.60
Telomerase Components in Cell Signaling	0.72	Rac1 Pathway	0.58

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Signal transduction by L1	0.12

VEGF Family Ligands and Receptor Interactions

	VEGF Family Ligands and Receptor Interactions	1.00			Development VEGF-family signaling	0.36
	Development_VEGF-family signaling	0.36

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	1.00			CRMPs in Sema3A signaling	0.36
	Sema3A PAK dependent Axon repulsion	0.45

Signaling by VEGF

	Signaling by VEGF	1.00			Neurophilin interactions with VEGF and VEGFR	0.36
	VEGF ligand-receptor interactions	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for NRP1

	Development VEGF-family signaling
	Neurophysiological process Receptor-mediated axon growth repulsion

5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NRP1 (see all 26)

	MAPK Signaling
	Nuclear Receptor Activation by Vitamin-A
	DHA Signaling
	Actin-Based Motility by Rho Family GTPases
	Telomerase Components in Cell Signaling

1 Cell Signaling Technology (CST) Pathway for NRP1

Neuroscience

2 GeneGo (Thomson Reuters) Pathways for NRP1

	Development VEGF-family signaling
	Neurophysiological process Receptor-mediated axon growth repulsion

2 BioSystems Pathways for NRP1

	Signaling events mediated by VEGFR1 and VEGFR2
	VEGFR1 specific signals

5/13 Reactome Pathways for NRP1 (see all 13)

	CRMPs in Sema3A signaling
	L1CAM interactions
	Developmental Biology
	VEGF ligand-receptor interactions
	Signaling by VEGF

1 PharmGKB Pathway for NRP1

VEGF Signaling Pathway

1 Kegg Pathway (Kegg details for NRP1):

Axon guidance

NRP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NRP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for NRP1 (O14786^{1, 2, 3} ENSP00000265371⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KDR	P35968²^,³, ENSP00000263923⁴	MINT-2834292 I2D: score=3 STRING: ENSP00000263923
PGF	P49763³, ENSP00000238607⁴	I2D: score=2 STRING: ENSP00000238607
PLXNA1	Q9UIW2³, ENSP00000251772⁴	I2D: score=2 STRING: ENSP00000251772
VEGFB	P49765³, ENSP00000311127⁴	I2D: score=2 STRING: ENSP00000311127
FGF4	P08620³, ENSP00000168712⁴	I2D: score=1 STRING: ENSP00000168712

About this table

Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	--	--
GO:0001569	patterning of blood vessels	IEA	--
GO:0001938	positive regulation of endothelial cell proliferation	TAS	--
GO:0007155	cell adhesion	IEA	--
GO:0007165	signal transduction	TAS	9288753

NRP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NRP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NRP1

2 DrugBank Compounds for NRP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Palifermin	FGF-7 (see all 5)	162394-19-6	target	--	9094999 9890894 10821861
Pegaptanib	--	222716-86-1	target	--	17717967

10/44 Novoseek chemical compound relationships for NRP1 gene (see all 44) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	83.1	429	12618892 (5), 19837659 (5), 12142468 (4), 16211223 (4) (see all 99)
tyrosine	66.1	92	15254962 (2), 9565626 (1), 9924144 (1), 16155937 (1) (see all 80)
matrigel	36.2	5	18065694 (1), 18559514 (1), 20102335 (1), 12588764 (1)
bcma	30.6	2	16572839 (1), 15692072 (1)
gp 130	23.4	4	8157624 (1), 7813426 (1), 10835339 (1)
phosphotyrosine	21	1	12535520 (1)
erlotinib	20.3	1	17030089 (1)
heparin	16.5	14	18325345 (4), 16899214 (2), 15695515 (2), 16014624 (1) (see all 9)
phosphatidylinositol	13.3	1	18922901 (1)
threonine	12.3	7	8415726 (1), 16155937 (1), 20363638 (1), 8199354 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about NRP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NRP1 gene (5 alternative transcripts):

NM_001024628.2 NM_001024629.2 NM_001244972.1 NM_001244973.1 NM_003873.5

Unigene Cluster for NRP1:

Neuropilin 1

Hs.131704 [show with all ESTs]

Unigene Representative Sequence: NM_003873

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265371 ENST00000374875 ENST00000413802 ENST00000418675 ENST00000466932

ENST00000431894 ENST00000374822 ENST00000374821 ENST00000374823(uc001ixb.2)

ENST00000432372 ENST00000455749 ENST00000374867(uc001iwv.4 uc001iwy.4 uc009xlz.3 uc001iwx.4 uc001iww.4 uc001iwz.2 uc001ixa.2 uc001ixc.1)

ENST00000395995 ENST00000374816

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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRP1

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRP1

Additional cDNA sequence:

AB209641.1 AF016050.1 AF018956.1 AF086016.1 AF145712.1 AF268691.1 AF280547.1 AK091354.1

AK292822.1 AL833608.1 AY249243.1 BC007533.1 BC007737.2 BT006995.1 BX510902.1 BX648025.1

BX648250.1 CR749333.1 NR_045259.1

24/36 DOTS entries (see all 36):

DT.95079366 DT.100842118 DT.95079364 DT.316620 DT.99989377 DT.101984950 DT.121253908 DT.92425896

DT.100761247 DT.121253887 DT.92030573 DT.100842099 DT.121642543 DT.95186420 DT.75149118 DT.86821083

DT.95139739 DT.95169770 DT.95297338 DT.121253933 DT.121630519 DT.121631638 DT.121635095 DT.40246275

24/346 AceView cDNA sequences (see all 346):

D82789 AA454667 AF086016 BC007533 AI473540 H88305 AA609131 AI636303

CB240576 BU628968 BM999961 AV726290 BX337066 BU838374 BE877043 AW069568

AL701129 AI474278 BM263250 AW769458 BQ897097 AA446416 AA181921 AF280547

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NRP1 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	^	14	^
SP1:													-																		-								-				-		-				-
SP2:													-																		-								-						-				-
SP3:													-																		-								-						-				-
SP4:													-																		-								-						-
SP5:													-																		-

ExUns:	15a	·	15b	·	15c	^	16	^	17	^	18a	·	18b
SP1:
SP2:
SP3:									-
SP4:
SP5:

ECgene alternative splicing isoforms for NRP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NRP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NRP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Endothelium

Arteries

Arterial endothelial cells

Selective marker (cell-identifying gene)

Endothelium

Heart

Dorsal Aorta

Arterial Endothelial Cells

Endothelium

Lateral Plate Mesoderm

Embryonic Capillary Plexus

Angioblasts

Endothelium

Lateral Plate Mesoderm

Paired Dorsal Aorta

Arterial endothelial cells

Endothelium

Lateral Plate Mesoderm

Endothelium

Venous Endothelial Cells

Endothelium

Bone

Autopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Stylopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Zeugopod Growth Plate

Hypertrophic Chondrocytes

Bone, Cartilage

Brain

Substantia Nigra pars Compacta

Embryonic Dopaminergic Neurons

Dopaminergic neurons

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

Trophoblast-like cells (Generation of tropho...)

CD31, CD144 positive cells (Two-step protocol fo...)

Primordial germ cell-like cells (Reconstitution of mo...)

Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

Mesendoderm (Derivation and sorti...)

See NRP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NRP1

SOURCE GeneReport for Unigene cluster: Hs.131704

UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786

Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood

vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult

tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and

pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules

SABiosciences Expression via Pathway-Focused PCR Arrays including NRP1 (see all 6):

Neurogenesis in human mouse rat

Estrogen Receptor Signaling in human mouse rat

Terminal Differentiation Markers in human mouse rat

WNT Signaling Targets in human mouse rat

VEGF Signaling in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NRP1 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NRP1¹	neuropilin 1	77.63(n) 82.02(a)		395560 NM_204782.1 NP_990113.1
lizard (Anolis carolinensis)	Reptilia	NRP1⁶	--	80(a)	1 ↔ 1	6(12111641-12204845)
African clawed frog (Xenopus laevis)	Amphibia	LOC397804²	A5-protein	76.77(n)		D10467.1
zebrafish (Danio rerio)	Actinopterygii	nrp1²	neuropilin 1	76.54(n)		353246 AB088776.1

ENSEMBL Gene Tree for NRP1 (if available)
TreeFam Gene Tree for NRP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NRP1 gene

DCBLD1² EDIL3² NRP2² MFGE8² DCBLD2² RS1²

18/34 SIMAP similar genes for NRP1 using alignment to 20 protein entries: NRP1_HUMAN (see all proteins) (see all similar genes):

DKFZp686A03134 DKFZp781F1414 NRP2 DKFZp686J1169 C1S NETO2

C10orf112 CNTNAP2 LRP12 MDGA1 TMPRSS15 DDR1

CDCP2 F8C TLL1 CUBN NPNT MAMDC2

NRP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74592913^1,2	C,F,	unknown	33614648(+)	`AATATA/C/TATCTC`	6	--	int¹		3		CSA WA	122
rs61761996^1,2	C,F,	--	33465925(-)	`AAGGGG/ACCCTT`	4	--	ds500¹ int¹		4		NS WA	196
rs183513954^1,2		--	33465963(+)	`ATTGTC/TATTAT`	4	--	int¹ ds500¹		0	--	--	--	--
rs2506136^1,2	C,F,A,	--	33466005(+)	`AAACTC/TTCCTA`	4	--	ds500¹ int¹		11		NA NS WA CSA EA	446
rs2506137^1,2	C,F,O,A,H,	--	33466043(+)	`TCATAC/TCCAAC`	4	--	int¹ ds500¹		25		NA NS EA WA CSA	2454
rs187945576^1,2		--	33466069(+)	`AATGCA/CGCGTG`	4	--	int¹ ds500¹		0	--	--	--	--
rs2506138^1,2	C,F,O,	--	33466071(+)	`TGCAGC/TGTGGG`	4	--	ds500¹ int¹		14		NA NS WA CSA EA	564
rs78594085^1,2	F,	--	33466075(+)	`GCGTGG/AGTGCA`	4	--	int¹ ds500¹		1		WA	118
rs193223897^1,2		--	33466119(+)	`TGCAAG/TAACAA`	4	--	ds500¹ int¹		0	--	--	--	--
rs141160637^1,2		--	33466147(+)	`GTGAAC/TATGAT`	4	--	int¹ ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NRP1 (33466419 - 33625190 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for NRP1
5 Indels: 11469 70951 61001 42771 39739

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NRP1 for disorders           About GeneDecksing

OMIM gene information: 602069    OMIM disorders: --

20/94 diseases for NRP1 (see all 94):    About MalaCards

human t-cell leukemia virus type 1 proliferative diabetic retinopathy non-small cell lung carcinoma diabetic retinopathy

dengue hemorrhagic fever malignant pleural mesothelioma multiple endocrine neoplasia hemorrhagic fever

alagille syndrome cadasil primary effusion lymphoma b-cell lymphomas

myeloid leukemia chorioangioma malignant glioma carcinoma

retinal vascular disease acute lymphoblastic leukemia rheumatoid arthritis basal cell carcinoma

2 diseases from the University of Copenhagen DISEASES database for NRP1:

Cancer Acute hemorrhagic leukoencephalitis

10/68 Novoseek disease relationships for NRP1 gene (see all 68) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	50.7	155	17369861 (5), 12883660 (5), 15233640 (4), 16959272 (4) (see all 86)
neovascularization	45.7	4	12412174 (1), 12608516 (1), 18818406 (1), 17196035 (1)
cancer	37.4	33	17699853 (8), 20486537 (2), 19817889 (2), 11267935 (1) (see all 17)
metastasis	33.5	17	15104297 (2), 9001250 (1), 17699853 (1), 19240167 (1) (see all 14)
cadasil	33.1	1	19539236 (1)
pancreatic cancer	32.4	27	15956974 (7), 20023433 (5), 17974973 (1), 20154461 (1) (see all 10)
men 2a	32.4	1	7624118 (1)
breast cancer	29.3	30	18715621 (3), 17550303 (2), 12216067 (2), 17162739 (2) (see all 16)
alagille syndrome	28.4	1	10196361 (1)
sarcoma avian	26.2	1	15137076 (1)

Human Genome Epidemiology (HuGE) Navigator: NRP1 (25 documents)

Export disorders for NRP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NRP1 gene, integrated from 9 sources (see all 610):
(articles sorted by number of sources associating them with NRP1)

Utopia: connect your pdf to the dynamic
world of online information

Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. (PubMed id 9529250)^{1, 2, 3, 9} Soker S.... Klagsbrun M. (1998)
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PubMed id 9331348)^{1, 3, 9} Chen H.... Tessier-Lavigne M. (1997)
Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF. (PubMed id 10748121)^{1, 2, 9} Gluzman-Poltorak Z.... Neufeld G. (2000)
Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling. (PubMed id 16763549)^{1, 2} Shintani Y.... Hori M. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Crystal structure of the human neuropilin-1 b1 domain. (PubMed id 12517344)^{1, 2} Lee C.C.... Spraggon G. (2003)
Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity. (PubMed id 10688880)^{1, 2} Gagnon M.L.... Klagsbrun M. (2000)
Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. (PubMed id 10520995)^{1, 2} Tamagnone L.... Comoglio P.M. (1999)
Neuropilin is a receptor for the axonal chemorepellent semaphorin III. (PubMed id 9288753)^{1, 2} He Z. and Tessier-Lavigne M. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8829	HGNC: 8004	AceView: NRP1	Ensembl:ENSG00000099250	euGenes: HUgn8829
ECgene: NRP1	Kegg: 8829	H-InvDB: NRP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NRP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NRP1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NRP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NRP1 gene:
Search GeneIP for patents involving NRP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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neuropilin 1

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NRP1 Gene

neuropilin 1

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