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NRP1 Gene

protein-coding   GIFtS: 69
GCID: GC10M033466

Neuropilin 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuropilin 11 2     CD3042
NRP2 3 5     NP12
VEGF165R2 3 5     neuropilin-12
Vascular Endothelial Cell Growth Factor 165 Receptor2 3     Transmembrane Receptor2
BDCA42     CD304 Antigen3

External Ids:    HGNC: 80041   Entrez Gene: 88292   Ensembl: ENSG000000992507   OMIM: 6020695   UniProtKB: O147863   

Export aliases for NRP1 gene to outside databases

Previous GC identifers: GC10M033216 GC10M033616 GC10M033470 GC10M033506


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRP1 Gene:
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate
in several different types of signaling pathways that control cell migration. Neuropilins contain a large
N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains.
These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind
many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the
ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family
members. Several alternatively spliced transcript variants that encode different protein isoforms have been
described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for NRP1 Gene:
NRP1 (neuropilin 1) is a protein-coding gene. Diseases associated with NRP1 include acute hemorrhagic leukoencephalitis, and retinal vascular disease. GO annotations related to this gene include heparin binding and coreceptor activity. An important paralog of this gene is DCBLD1.

UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786
Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in
angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It
mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The
VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well
as increased chemotaxis. It may regulate VEGF-induced angiogenesis
Function: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce
apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has
an averse effect on blood vessel number and integrity

Gene Wiki entry for NRP1 (Neuropilin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRP1 gene promoter:
         CREB   MyoD   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRP1 promoter sequence
   Search Chromatin IP Primers for NRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12   Ensembl cytogenetic band:  10p11.22   HGNC cytogenetic band: 10p12

NRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRP1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M033466:  view genomic region     (about GC identifiers)

Start:
33,466,419 bp from pter      End:
33,625,190 bp from pter
Size:
158,772 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786 (See protein sequence)
Recommended Name: Neuropilin-1 precursor  
Size: 923 amino acids; 103134 Da
Subunit: Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1
6 PDB 3D structures from and Proteopedia for NRP1:
1KEX (3D)        2QQI (3D)        2QQM (3D)        2QQN (3D)        3I97 (3D)        4DEQ (3D)    
Secondary accessions: B0LPG9 O60461 Q5T7F1 Q5T7F2 Q5T7F3 Q86T59 Q96I90 Q96IH5
Alternative splicing: 3 isoforms:  O14786-1   O14786-2   O14786-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NRP1: NX_O14786

Explore proteomics data for NRP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys53, Lys106
  • Glycosylation2 at Asn150, Asn261, Asn300, Asn522, Ser612, Thr827, Ser829, Thr830, Asn842, Ser844
  • Modification sites at PhosphoSitePlus

  • See NRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001019799.1  NP_001019800.1  NP_001231901.1  NP_001231902.1  NP_003864.4  

    ENSEMBL proteins: 
     ENSP00000364009   ENSP00000265371   ENSP00000390447   ENSP00000416147   ENSP00000476896  
     ENSP00000393071   ENSP00000363954   ENSP00000363955   ENSP00000363956   ENSP00000408911  
     ENSP00000390567   ENSP00000364001   ENSP00000379317   ENSP00000363949  
    Reactome Protein details: O14786

    NRP1 Human Recombinant Protein Products:

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    OriGene Purified Proteins for NRP1
    OriGene Protein Over-expression Lysate for NRP1
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    Novus Biologicals NRP1 Proteins
    Novus Biologicals NRP1 Lysates
    Sino Biological Recombinant Protein for NRP1
    Sino Biological Cell Lysate for NRP1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NRP1

    NRP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NRP1
    R&D Systems Antibodies for NRP1 (Neuropilin-1)
    Cell Signaling Technology (CST) Antibodies for NRP1 
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    OriGene Custom Antibody Services for NRP1
    Novus Biologicals NRP1 Antibodies
    Abcam antibodies for NRP1 (O14786, Q5T7F3)
    Cloud-Clone Corp. Antibodies for NRP1
    ThermoFisher Antibody for NRP1
    LSBio Antibodies in human, mouse, rat for NRP1

    NRP1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NRP1
    Cloud-Clone Corp. CLIAs for NRP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    Selected InterPro protein domains (see all 8):
     IPR000859 CUB_dom
     IPR000998 MAM_dom
     IPR014648 Neuropilin
     IPR022579 Neuropilin1_C
     IPR000421 Coagulation_fac_5/8-C_type_dom

    Graphical View of Domain Structure for InterPro Entry O14786

    ProtoNet protein and cluster: O14786

    3 Blocks protein domains:
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB000859 CUB domain
    IPB000998 MAM domain signature


    UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786
    Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for
    heparin and VEGF binding
    Similarity: Belongs to the neuropilin family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 2 F5/8 type C domains
    Similarity: Contains 1 MAM domain


    NRP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRP1_HUMAN, O14786
    Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in
    angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It
    mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The
    VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well
    as increased chemotaxis. It may regulate VEGF-induced angiogenesis
    Function: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce
    apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has
    an averse effect on blood vessel number and integrity

         Genatlas biochemistry entry for NRP1:
    neuropilin 1,cell surface glycoprotein,expressed by the developing nervous system, complexing with plexin
    1(PLXN1),implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial
    growth factor-165 receptor,with dominant negative form resulting from the deletion of an extracellular
    domain,necessary component of receptor complexes for some,but not all,secreted semaphorin family members

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005021vascular endothelial growth factor-activated receptor activity NAS19909241
    GO:0005515protein binding IPI16763549
    GO:0008201heparin binding IEA--
    GO:0015026coreceptor activity TAS--
    GO:0017154semaphorin receptor activity NAS19909241
         
    NRP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NRP1:
     Increased peripheral focal adh  Increased resistance to Trastu  Weaker migration 

         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nrp1):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  immune system  mortality/aging  nervous system  vision/eye 

    NRP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NRP1: Nrp1tm2.1Ddg Nrp1tm1Hfu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NRP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NRP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NRP1:
    hsa-mir-16-5p (MIRT031601), hsa-mir-1 (MIRT001352), hsa-mir-181a-5p (MIRT025124), hsa-mir-124-3p (MIRT022578), hsa-mir-186-5p (MIRT021183), hsa-mir-335-5p (MIRT017659)

    Block miRNA regulation of human, mouse, rat NRP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRP1 (see all 80):
    hsa-miR-3607-3p hsa-miR-361-5p hsa-miR-376b hsa-miR-4272 hsa-miR-200a hsa-miR-1244 hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidNRP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NRP1
    Predesigned siRNA for gene silencing in human, mouse, rat NRP1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for NRP1 (see all 16)
    OriGene ORF clones in mouse, rat for NRP1
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    GenScript: all cDNA clones in your preferred vector (see all 3): NRP1 (NM_003873)
    Sino Biological Human cDNA Clone for NRP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRP1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for NRP1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRP1_HUMAN, O14786: Cell membrane; Single-pass type I membrane protein
    NRP1_HUMAN, O14786: Isoform 2: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol4
    cytoskeleton2
    endoplasmic reticulum2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002116semaphorin receptor complex NAS19909241
    GO:0005576extracellular region IEA--
    GO:0005829cytosol IDA--
    GO:0005883neurofilament IEA--
    GO:0005886plasma membrane TAS--

    NRP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NRP1 About   (see all 23)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1VEGF Pathway
    VEGF Family Ligands and Receptor Interactions0.66
    Development VEGF family signaling0.36
    2VEGF Signaling Pathway
    VEGF Signaling Pathway0.34
    VEGF Signaling0.34
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    PPAR Pathway0.66
    Cellular Apoptosis Pathway0.85
    Rac1 Pathway0.65
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    CHL1 interactions0.00
    5Semaphorin interactions
    Semaphorin interactions0.43
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion0.00
    Sema3A PAK dependent Axon repulsion0.00
    CRMPs in Sema3A signaling0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NRP1
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NRP1 (see all 26)
        MAPK Signaling
    Nuclear Receptor Activation by Vitamin-A
    DHA Signaling
    Actin-Based Motility by Rho Family GTPases
    Telomerase Components in Cell Signaling

    1 Cell Signaling Technology (CST) Pathway for NRP1
        Neuroscience

    2 GeneGo (Thomson Reuters) Pathways for NRP1
        Development VEGF-family signaling
    Neurophysiological process Receptor-mediated axon growth repulsion

    2 BioSystems Pathways for NRP1
        VEGFR1 specific signals
    Signaling events mediated by VEGFR1 and VEGFR2

    1 Sino Biological Pathway for NRP1
        VEGF Signaling

    Selected Reactome Pathways for NRP1 (see all 6)
        CRMPs in Sema3A signaling
    Signal transduction by L1
    Sema3A PAK dependent Axon repulsion
    SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
    CHL1 interactions

    1 PharmGKB Pathway for NRP1
        VEGF Signaling Pathway

    2 Kegg Pathways  (Kegg details for NRP1):
        Axon guidance
    HTLV-I infection


    NRP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRP1 (see all 6): 
              Neurogenesis in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              WNT Signaling Targets in human mouse rat
              VEGF Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NRP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NRP1 (O147861, 2, 3 ENSP000002653714) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VEGFAP156921, 2, 3, ENSP000003611254EBI-1187100,EBI-1026643 MINT-2834244 MINT-2834194 MINT-2834269 I2D: score=4 STRING: ENSP00000361125
    KDRP359681, 2, 3, ENSP000002639234EBI-1187100,EBI-1005487 MINT-2834292 I2D: score=3 STRING: ENSP00000263923
    PGFP497633, ENSP000002386074I2D: score=2 STRING: ENSP00000238607
    PLXNA1Q9UIW23, ENSP000002517724I2D: score=2 STRING: ENSP00000251772
    VEGFBP497653, ENSP000003111274I2D: score=2 STRING: ENSP00000311127
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ----
    GO:0001569patterning of blood vessels ISS--
    GO:0001764neuron migration ISS--
    GO:0001938positive regulation of endothelial cell proliferation TAS--
    GO:0002042cell migration involved in sprouting angiogenesis ISS--

    NRP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NRP1

    2 DrugBank Compounds for NRP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    PaliferminFGF-7 (see all 5)162394-19-6target--9094999 9890894 10821861
    Pegaptanib-- 222716-86-1target--17717967

    Selected Novoseek inferred chemical compound relationships for NRP1 gene (see all 44)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 83.1 429 12618892 (5), 19837659 (5), 12142468 (4), 16211223 (4) (see all 99)
    tyrosine 66.1 92 15254962 (2), 9565626 (1), 9924144 (1), 16155937 (1) (see all 80)
    matrigel 36.2 5 18065694 (1), 18559514 (1), 20102335 (1), 12588764 (1)
    bcma 30.6 2 16572839 (1), 15692072 (1)
    gp 130 23.4 4 8157624 (1), 7813426 (1), 10835339 (1)
    phosphotyrosine 21 1 12535520 (1)
    erlotinib 20.3 1 17030089 (1)
    heparin 16.5 14 18325345 (4), 16899214 (2), 15695515 (2), 16014624 (1) (see all 9)
    phosphatidylinositol 13.3 1 18922901 (1)
    threonine 12.3 7 8415726 (1), 16155937 (1), 20363638 (1), 8199354 (1) (see all 7)



    NRP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NRP1 gene (5 alternative transcripts): 
    NM_001024628.2  NM_001024629.2  NM_001244972.1  NM_001244973.1  NM_003873.5  

    Unigene Cluster for NRP1:

    Neuropilin 1
    Hs.131704  [show with all ESTs]
    Unigene Representative Sequence: NM_003873
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374875 ENST00000265371 ENST00000413802 ENST00000418675 ENST00000466932
    ENST00000431894 ENST00000374821 ENST00000374822 ENST00000374823(uc001ixb.2)
    ENST00000432372 ENST00000455749 ENST00000374867(uc001iwv.4 uc001iwy.4 uc009xlz.3 uc001iwx.4 uc001iww.4 uc001iwz.2 uc001ixa.2 uc001ixc.1)
    ENST00000395995 ENST00000374816
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate NRP1 (see all 80):
    hsa-miR-3607-3p hsa-miR-361-5p hsa-miR-376b hsa-miR-4272 hsa-miR-200a hsa-miR-1244 hsa-miR-3148 hsa-miR-130b
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NRP1 (NM_003873)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRP1
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      QuantiTect SYBR Green Assays in human, mouse, rat NRP1
      QuantiFast Probe-based Assays in human, mouse, rat NRP1

    Additional mRNA sequence: 

    AB209641.1 AF016050.1 AF018956.1 AF086016.1 AF145712.1 AF268691.1 AF280547.1 AK091354.1 
    AK292822.1 AL833608.1 AY249243.1 BC007533.1 BC007737.2 BT006995.1 BX510902.1 BX648025.1 
    BX648250.1 CR749333.1 NR_045259.1 

    Selected DOTS entries (see all 36):

    DT.95079366  DT.100842118  DT.95079364  DT.316620  DT.99989377  DT.101984950  DT.121253908  DT.92425896 
    DT.100761247  DT.121253887  DT.92030573  DT.100842099  DT.121642543  DT.95186420  DT.75149118  DT.86821083 
    DT.97842399  DT.95139739  DT.95169770  DT.95297338  DT.121253933  DT.121630519  DT.121631638  DT.121635095 

    Selected AceView cDNA sequences (see all 346):

    AI474278 AW769458 AA609131 H88305 BQ897097 BM263250 D82789 AW069568 
    AA446416 AF086016 AI636303 CB240576 BE877043 T54603 BM670615 BM998074 
    BX473948 AI581430 AI358687 AF280547 AL597838 AI524399 AA181921 BQ023037 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NRP1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^
    SP1:                                      -                                                     -                       -           -     -           -         
    SP2:                                      -                                                     -                       -                 -           -         
    SP3:                                      -                                                     -                       -                 -           -         
    SP4:                                      -                                                     -                       -                 -                     
    SP5:                                      -                                                     -                                                               

    ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                          
    SP2:                                          
    SP3:                          -               
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for NRP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NRP1 Expression
    About this image


    NRP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 9 entries
             Arterial Endothelial Cells Arteries
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Angioblasts Proepicardium
     
     Tooth (Integumentary System)    fully expand to see all 6 entries
             Odontoblasts Dentin
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Hypertrophic Chondrocytes Stylopod Growth Plate
             Bone Marrow
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Arterial Endothelial Cells Dorsal Aorta
    NRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131704

    UniProtKB/Swiss-Prot: NRP1_HUMAN, O14786
    Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the
    blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In
    adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney
    and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRP1 (see all 6): 
              Neurogenesis in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              WNT Signaling Targets in human mouse rat
              VEGF Signaling in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for NRP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrp11 , 5 neuropilin 11, 5 87.36(n)1
    93.28(a)1
      8 (75.78 cM)5
    181861  NM_008737.21  NP_032763.21 
     1283590735 
    chicken
    (Gallus gallus)
    Aves NRP11 neuropilin 1 78.21(n)
    83.18(a)
      395560  NM_204782.1  NP_990113.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRP16
    neuropilin 1
    79(a)
    1 ↔ 1
    6(12050085-12209652)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978042 A5-protein 76.77(n)    D10467.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nrp12 neuropilin 1 76.54(n)   353246  AB088776.1 


    ENSEMBL Gene Tree for NRP1 (if available)
    TreeFam Gene Tree for NRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRP1 gene
    DCBLD12  EDIL32  MFGE82  DCBLD22  F82  RS12  NRP22  F52  
    Selected SIMAP similar genes for NRP1 using alignment to 19 protein entries:     NRP1_HUMAN (see all proteins) (see all similar genes):
    DKFZp781F1414    DKFZp686A03134    NRP2    DKFZp686J1169    DIET1    C1S
    MALRD1    DDR1    CNTNAP2    MDGA1    TMPRSS15    CDCP2
    F8C    TLL1    CUBN    NPNT    MAMDC2    SEZ6

    NRP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRP1 (see all 3445)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745929131,2
    C,Funtested133514075(+) AATATA/C/TATCTC 6 -- int13CSA WA 122
    rs617619961,2
    C,F--33365322(-) AAGGGG/ACCCTT 4 -- int1 ds50014Minor allele frequency- A:0.20NS WA 196
    rs1835139541,2
    --33365360(+) ATTGTC/TATTAT 4 -- int1 ds50010--------
    rs25061361,2
    C,F,A--33365402(+) AAACTC/TTCCTA 4 -- int1 ds500111Minor allele frequency- T:0.49NA NS WA CSA EA 446
    rs25061371,2
    C,F,O,A,H--33365440(+) TCATAC/TCCAAC 4 -- int1 ds500125Minor allele frequency- T:0.48NA NS EA WA CSA 2454
    rs1879455761,2
    --33365466(+) AATGCA/CGCGTG 4 -- int1 ds50010--------
    rs25061381,2
    C,F,O--33365468(+) TGCAGC/TGTGGG 4 -- int1 ds500114Minor allele frequency- T:0.48NA NS WA CSA EA 564
    rs785940851,2
    F--33365472(+) GCGTGG/AGTGCA 4 -- int1 ds50011Minor allele frequency- A:0.03WA 118
    rs1932238971,2
    --33365516(+) TGCAAG/TAACAA 4 -- int1 ds50010--------
    rs1411606371,2
    --33365544(+) GTGAAC/TATGAT 4 -- int1 ds50010--------

    HapMap Linkage Disequilibrium report for NRP1 (33466419 - 33625190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NRP1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678844CNV Deletion23128226
    esv2662402CNV Deletion23128226
    esv2735262CNV Deletion23290073
    esv4611CNV Deletion18987735
    nsv6299CNV Insertion18451855
    esv268350CNV Insertion20981092
    nsv24782CNV Loss16902084
    nsv825336CNV Loss20364138
    esv8432CNV Loss19470904
    esv27085CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for NRP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602069    OMIM disorders: --

    Selected diseases for NRP1 (see all 89):    
    About MalaCards
    acute hemorrhagic leukoencephalitis    retinal vascular disease    chorioangioma    multiple endocrine neoplasia type 2a
    alagille syndrome    cadasil    diabetic retinopathy    sporadic pheochromocytoma
    endotheliitis    proliferative diabetic retinopathy    primary effusion lymphoma    lymphoid leukemia
    choroiditis    digeorge syndrome    osteonecrosis    tetralogy of fallot
    hirschsprung's disease    dengue hemorrhagic fever    colon adenocarcinoma    multiple endocrine neoplasia

    2 diseases from the University of Copenhagen DISEASES database for NRP1:
    Acute hemorrhagic leukoencephalitis     Cancer

    NRP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for NRP1 gene (see all 68)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 50.7 155 17369861 (5), 12883660 (5), 15233640 (4), 16959272 (4) (see all 86)
    neovascularization 45.7 4 12412174 (1), 12608516 (1), 18818406 (1), 17196035 (1)
    cancer 37.4 33 17699853 (8), 20486537 (2), 19817889 (2), 11267935 (1) (see all 17)
    metastasis 33.5 17 15104297 (2), 9001250 (1), 17699853 (1), 19240167 (1) (see all 14)
    cadasil 33.1 1 19539236 (1)
    pancreatic cancer 32.4 27 15956974 (7), 20023433 (5), 17974973 (1), 20154461 (1) (see all 10)
    men 2a 32.4 1 7624118 (1)
    breast cancer 29.3 30 18715621 (3), 17550303 (2), 12216067 (2), 17162739 (2) (see all 16)
    alagille syndrome 28.4 1 10196361 (1)
    sarcoma avian 26.2 1 15137076 (1)

    Genetic Association Database (GAD): NRP1
    Human Genome Epidemiology (HuGE) Navigator: NRP1 (25 documents)

    Export disorders for NRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRP1 gene, integrated from 10 sources (see all 632):
    (articles sorted by number of sources associating them with NRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. (PubMed id 9529250)1, 2, 3, 9 Soker S.... Klagsbrun M. (Cell 1998)
    2. The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer. (PubMed id 18638267)1, 4, 9 Nagy N....SzAcll M. (Wound Repair Regen 2008)
    3. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. (PubMed id 9331348)1, 3, 9 Chen H.... Tessier-Lavigne M. (Neuron 1997)
    4. Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head. (PubMed id 20215856)1, 4, 9 Hong J.M....Kim S.Y. (amp 2010)
    5. Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes. (PubMed id 18785001)1, 4, 9 Schneider B.P....Sledge G.W. (Breast Cancer Res. Treat. 2009)
    6. Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF. (PubMed id 10748121)1, 2, 9 Gluzman-Poltorak Z.... Neufeld G. (J. Biol. Chem. 2000)
    7. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. (PubMed id 21682944)1, 4 Alkelai A....Lerer B. (Int. J. Neuropsychopharmacol. 2012)
    8. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    9. Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S0415). (PubMed id 20631636)1, 4 Gold P.J....Blanke C.D. (J Thorac Oncol 2010)
    10. Genetic association of the neuropilin-1 gene with type 1 diabetes in children: Neuropilin-1 expression in pancreatic islets. (PubMed id 20053475)1, 4 Hasan N.M....MacDonald M.J. (Diabetes Res. Clin. Pract. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8829 HGNC: 8004 AceView: NRP1 Ensembl:ENSG00000099250 euGenes: HUgn8829
    ECgene: NRP1 Kegg: 8829 H-InvDB: NRP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NRP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NRP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NRP1 gene:
    Search GeneIP for patents involving NRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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