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Aliases for NRP1 Gene

Aliases for NRP1 Gene

  • Neuropilin 1 2 3 5
  • Vascular Endothelial Cell Growth Factor 165 Receptor 3 4
  • VEGF165R 3 4
  • NRP 3 4
  • Transmembrane Receptor 3
  • CD304 Antigen 4
  • BDCA4 3
  • CD304 3
  • NP1 3

External Ids for NRP1 Gene

Previous GeneCards Identifiers for NRP1 Gene

  • GC10M033616
  • GC10M033470
  • GC10M033506
  • GC10M033466

Summaries for NRP1 Gene

Entrez Gene Summary for NRP1 Gene

  • This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NRP1 Gene

NRP1 (Neuropilin 1) is a Protein Coding gene. Diseases associated with NRP1 include acute hemorrhagic leukoencephalitis and angiomatous meningioma. Among its related pathways are Axon guidance and HTLV-I infection. GO annotations related to this gene include heparin binding and growth factor binding. An important paralog of this gene is NRP2.

UniProtKB/Swiss-Prot for NRP1 Gene

  • The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.

  • The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Gene Wiki entry for NRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRP1 Gene

Genomics for NRP1 Gene

Regulatory Elements for NRP1 Gene

Enhancers for NRP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRP1 Gene

Chromosome:
10
Start:
33,177,491 bp from pter
End:
33,336,262 bp from pter
Size:
158,772 bases
Orientation:
Minus strand

Genomic View for NRP1 Gene

Genes around NRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRP1 Gene

Proteins for NRP1 Gene

  • Protein details for NRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14786-NRP1_HUMAN
    Recommended name:
    Neuropilin-1
    Protein Accession:
    O14786
    Secondary Accessions:
    • B0LPG9
    • O60461
    • Q5T7F1
    • Q5T7F2
    • Q5T7F3
    • Q86T59
    • Q96I90
    • Q96IH5

    Protein attributes for NRP1 Gene

    Size:
    923 amino acids
    Molecular mass:
    103134 Da
    Quaternary structure:
    • Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1.

    Three dimensional structures from OCA and Proteopedia for NRP1 Gene

    Alternative splice isoforms for NRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRP1 Gene

Proteomics data for NRP1 Gene at MOPED

Post-translational modifications for NRP1 Gene

  • Ubiquitination at Lys 53 and Lys 106
  • Glycosylation at Asn 150, Asn 261, Asn 300, Asn 522, Ser 612, Thr 827, Thr 830, and Asn 842
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NRP1 (NRP1)

No data available for DME Specific Peptides for NRP1 Gene

Domains & Families for NRP1 Gene

Gene Families for NRP1 Gene

Graphical View of Domain Structure for InterPro Entry

O14786

UniProtKB/Swiss-Prot:

NRP1_HUMAN :
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
  • Belongs to the neuropilin family.
Domain:
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
  • Contains 2 CUB domains.
  • Contains 2 F5/8 type C domains.
  • Contains 1 MAM domain.
Family:
  • Belongs to the neuropilin family.
genes like me logo Genes that share domains with NRP1: view

Function for NRP1 Gene

Molecular function for NRP1 Gene

GENATLAS Biochemistry:
neuropilin 1,cell surface glycoprotein,expressed by the developing nervous system, complexing with plexin 1(PLXN1),implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor,with dominant negative form resulting from the deletion of an extracellular domain,necessary component of receptor complexes for some,but not all,secreted semaphorin family members
UniProtKB/Swiss-Prot Function:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
UniProtKB/Swiss-Prot Function:
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
genes like me logo Genes that share phenotypes with NRP1: view

Animal Models for NRP1 Gene

MGI Knock Outs for NRP1:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRP1 Gene

Localization for NRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRP1 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRP1 Gene COMPARTMENTS Subcellular localization image for NRP1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
endosome 4
cytoskeleton 3
endoplasmic reticulum 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 21245381
GO:0005883 neurofilament IEA --
GO:0097443 sorting endosome ISS 23639442
genes like me logo Genes that share ontologies with NRP1: view

Pathways & Interactions for NRP1 Gene

genes like me logo Genes that share pathways with NRP1: view

SIGNOR curated interactions for NRP1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS 24401374
GO:0001569 patterning of blood vessels ISS 24401374
GO:0001764 neuron migration ISS --
GO:0002040 sprouting angiogenesis ISS 24401374
GO:0002042 cell migration involved in sprouting angiogenesis ISS --
genes like me logo Genes that share ontologies with NRP1: view

Drugs & Compounds for NRP1 Gene

(23) Drugs for NRP1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palifermin Approved Pharma binder, Target 0
pegaptanib Approved, Investigational Pharma Target 0
Ranibizumab Approved Pharma 463
Angiogenesis Inhibitors Pharma 4008
Antibodies Pharma 5531

(28) Additional Compounds for NRP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRP1: view

Transcripts for NRP1 Gene

Unigene Clusters for NRP1 Gene

Neuropilin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - -
SP10:
SP11:

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NRP1 Gene

GeneLoc Exon Structure for
NRP1
ECgene alternative splicing isoforms for
NRP1

Expression for NRP1 Gene

mRNA expression in normal human tissues for NRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NRP1 Gene

This gene is overexpressed in Amniocyte (14.5), Serum (11.7), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRP1 Gene



SOURCE GeneReport for Unigene cluster for NRP1 Gene Hs.131704

mRNA Expression by UniProt/SwissProt for NRP1 Gene

O14786-NRP1_HUMAN
Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
genes like me logo Genes that share expression patterns with NRP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for NRP1 Gene

Orthologs for NRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRP1 35
  • 90.58 (n)
  • 95.68 (a)
NRP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRP1 35
  • 91.57 (n)
  • 96.56 (a)
NRP1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrp1 35
  • 87.36 (n)
  • 93.28 (a)
Nrp1 16
Nrp1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRP1 35
  • 99.39 (n)
  • 99.67 (a)
NRP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrp1 35
  • 87.74 (n)
  • 93.38 (a)
oppossum
(Monodelphis domestica)
Mammalia NRP1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRP1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRP1 35
  • 78.21 (n)
  • 83.18 (a)
NRP1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRP1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrp1 35
  • 71.99 (n)
  • 73.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397804 35
zebrafish
(Danio rerio)
Actinopterygii nrp1 35
nrp1a 35
  • 66.25 (n)
  • 67.72 (a)
nrp1a 36
  • 65 (a)
OneToMany
nrp1b 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7396 36
  • 23 (a)
OneToMany
Species with no ortholog for NRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRP1 Gene

ENSEMBL:
Gene Tree for NRP1 (if available)
TreeFam:
Gene Tree for NRP1 (if available)

Paralogs for NRP1 Gene

Paralogs for NRP1 Gene

genes like me logo Genes that share paralogs with NRP1: view

Variants for NRP1 Gene

Sequence variations from dbSNP and Humsavar for NRP1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7079053 - 33,263,768(+) TTGGC(A/G)CAAAG nc-transcript-variant, reference, missense
rs2228637 - 33,207,648(-) CGATT(C/G)ATCAG nc-transcript-variant, reference, missense
rs2228638 - 33,186,354(-) CCCAC(A/G)TCGGC nc-transcript-variant, reference, missense
rs1537174 -- 33,254,938(-) CACCA(C/T)GTCCC intron-variant
rs1555319 -- 33,201,235(-) TGAAG(C/G)CTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRP1 Gene

Variant ID Type Subtype PubMed ID
nsv831829 CNV Loss 17160897
esv27085 CNV Loss 19812545
esv4611 CNV Deletion 18987735
esv2735262 CNV Deletion 23290073
esv2678844 CNV Deletion 23128226
nsv24782 CNV Loss 16902084
esv8432 CNV Loss 19470904
nsv825336 CNV Loss 20364138
nsv6299 CNV Insertion 18451855
nsv528133 CNV Loss 19592680
esv268350 CNV Insertion 20981092
esv2662402 CNV Deletion 23128226

Variation tolerance for NRP1 Gene

Residual Variation Intolerance Score: 9.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRP1 Gene

HapMap Linkage Disequilibrium report
NRP1
Human Gene Mutation Database (HGMD)
NRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP1 Gene

Disorders for NRP1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NRP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute hemorrhagic leukoencephalitis
  • acute haemorrhagic leucoencephalitis of weston hurst
angiomatous meningioma
truncus arteriosus
  • common aortico-pulmonary trunk
brachial plexus lesion
  • brachial plexus lesions
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search NRP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRP1

Genetic Association Database (GAD)
NRP1
Human Genome Epidemiology (HuGE) Navigator
NRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRP1
genes like me logo Genes that share disorders with NRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRP1 Gene

Publications for NRP1 Gene

  1. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. (PMID: 9529250) Soker S. … Klagsbrun M. (Cell 1998) 2 3 4 23 67
  2. Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells. (PMID: 20085644) Zhang S. … Wu D. (Mol. Cancer 2010) 3 23
  3. Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1. (PMID: 20363638) Novoa A. … Chapleur Y. (Bioorg. Med. Chem. 2010) 3 23
  4. Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes. (PMID: 18785001) Schneider B.P. … Sledge G.W. (Breast Cancer Res. Treat. 2009) 3 23
  5. Expression of the vascular endothelial growth factor receptor neuropilin-1 in the human endometrium. (PMID: 18996601) Hess A.P. … Kruessel J.S. (J. Reprod. Immunol. 2009) 3 23

Products for NRP1 Gene

Sources for NRP1 Gene

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