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Aliases for NRP1 Gene

Aliases for NRP1 Gene

  • Neuropilin 1 2 3 5
  • Vascular Endothelial Cell Growth Factor 165 Receptor 3 4
  • VEGF165R 3 4
  • NRP 3 4
  • Transmembrane Receptor 3
  • CD304 Antigen 4
  • Neuropilin-1 3
  • BDCA4 3
  • CD304 3
  • NP1 3

External Ids for NRP1 Gene

Previous GeneCards Identifiers for NRP1 Gene

  • GC10M033616
  • GC10M033470
  • GC10M033506
  • GC10M033466

Summaries for NRP1 Gene

Entrez Gene Summary for NRP1 Gene

  • This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NRP1 Gene

NRP1 (Neuropilin 1) is a Protein Coding gene. Diseases associated with NRP1 include Acute Hemorrhagic Leukoencephalitis and Angiomatous Meningioma. Among its related pathways are Phospholipase-C Pathway and CREB Pathway. GO annotations related to this gene include heparin binding and growth factor binding. An important paralog of this gene is NRP2.

UniProtKB/Swiss-Prot for NRP1 Gene

  • The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).

  • The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Gene Wiki entry for NRP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRP1 Gene

Genomics for NRP1 Gene

Regulatory Elements for NRP1 Gene

Enhancers for NRP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G033270 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +63.3 63284 4.7 PKNOX1 SIN3A FEZF1 ZNF2 YY1 GLIS2 FOS ZNF263 SP3 TSHZ1 NRP1 ITGB1 GC10M033237 RN7SL398P
GH10G033247 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +84.4 84351 8.8 SOX13 PKNOX1 FOXA2 SAP130 HINFP JUN ZNF384 RARA GATA2 POLR2A ENSG00000238258 NRP1 CCDC7 GC10M033237
GH10G033261 1.6 Ensembl ENCODE dbSUPER 11.8 +72.0 71979 5.1 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS NRP1 ENSG00000226842 GC10M033237 ENSG00000238258
GH10G033232 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +98.8 98788 9.6 SIN3A FEZF1 BMI1 RAD21 ZNF121 GATA2 SCRT2 FOS ZNF263 OVOL3 ENSG00000238258 NRP1 GC10M033237
GH10G033364 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -29.7 -29721 2.4 GTF2F1 JUN MAX FOSL1 CBX5 GATA2 FOS MAFK IKZF2 TCF7L2 NRP1 LOC105376488 LOC105376489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRP1 Gene

Chromosome:
10
Start:
33,177,491 bp from pter
End:
33,336,262 bp from pter
Size:
158,772 bases
Orientation:
Minus strand

Genomic View for NRP1 Gene

Genes around NRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRP1 Gene

Proteins for NRP1 Gene

  • Protein details for NRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14786-NRP1_HUMAN
    Recommended name:
    Neuropilin-1
    Protein Accession:
    O14786
    Secondary Accessions:
    • B0LPG9
    • O60461
    • Q5T7F1
    • Q5T7F2
    • Q5T7F3
    • Q86T59
    • Q96I90
    • Q96IH5

    Protein attributes for NRP1 Gene

    Size:
    923 amino acids
    Molecular mass:
    103134 Da
    Quaternary structure:
    • Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1. Interacts with VEGFA (PubMed:26503042).

    Three dimensional structures from OCA and Proteopedia for NRP1 Gene

    Alternative splice isoforms for NRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRP1 Gene

Post-translational modifications for NRP1 Gene

  • Ubiquitination at posLast=5353 and Lys106
  • Glycosylation at Asn150, Asn261, posLast=300300, Asn522, posLast=612612, posLast=827827, posLast=830830, and posLast=842842
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NRP1 (NRP1)

Assay Products

No data available for DME Specific Peptides for NRP1 Gene

Domains & Families for NRP1 Gene

Gene Families for NRP1 Gene

Graphical View of Domain Structure for InterPro Entry

O14786

UniProtKB/Swiss-Prot:

NRP1_HUMAN :
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
  • Belongs to the neuropilin family.
Domain:
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.
Family:
  • Belongs to the neuropilin family.
genes like me logo Genes that share domains with NRP1: view

Function for NRP1 Gene

Molecular function for NRP1 Gene

GENATLAS Biochemistry:
neuropilin 1,cell surface glycoprotein,expressed by the developing nervous system, complexing with plexin 1(PLXN1),implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor,with dominant negative form resulting from the deletion of an extracellular domain,necessary component of receptor complexes for some,but not all,secreted semaphorin family members
UniProtKB/Swiss-Prot Function:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
UniProtKB/Swiss-Prot Function:
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Gene Ontology (GO) - Molecular Function for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005021 vascular endothelial growth factor-activated receptor activity IEA,NAS 19909241
GO:0005515 protein binding IPI 16763549
GO:0008201 heparin binding IEA --
GO:0015026 coreceptor activity TAS 21245381
GO:0017154 semaphorin receptor activity NAS,IEA 19909241
genes like me logo Genes that share ontologies with NRP1: view
genes like me logo Genes that share phenotypes with NRP1: view

Animal Models for NRP1 Gene

MGI Knock Outs for NRP1:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRP1 Gene

Localization for NRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRP1 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 4
endosome 4
cytoskeleton 3
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex NAS 19909241
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005769 early endosome ISS 23639442
GO:0005829 cytosol IDA 21245381
genes like me logo Genes that share ontologies with NRP1: view

Pathways & Interactions for NRP1 Gene

genes like me logo Genes that share pathways with NRP1: view

SIGNOR curated interactions for NRP1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS 24401374
GO:0001569 branching involved in blood vessel morphogenesis ISS 24401374
GO:0001764 neuron migration ISS --
GO:0001938 positive regulation of endothelial cell proliferation TAS 21245381
GO:0002040 sprouting angiogenesis ISS 24401374
genes like me logo Genes that share ontologies with NRP1: view

Drugs & Compounds for NRP1 Gene

(26) Drugs for NRP1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palifermin Approved Pharma binder, Target 0
pegaptanib Approved, Investigational Pharma Target 0
Ranibizumab Approved Pharma 486
Angiogenesis Inhibitors Pharma 4257
Antibodies Pharma 6394

(27) Additional Compounds for NRP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for NRP1 Gene

Compound Action Cas Number
EG00229 Nrp1 inhibitor 1210945-69-9
genes like me logo Genes that share compounds with NRP1: view

Drug Products

Transcripts for NRP1 Gene

Unigene Clusters for NRP1 Gene

Neuropilin 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - -
SP10:
SP11:

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NRP1 Gene

GeneLoc Exon Structure for
NRP1
ECgene alternative splicing isoforms for
NRP1

Expression for NRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NRP1 Gene

This gene is overexpressed in Amniocyte (14.5), Serum (11.7), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NRP1 Gene:

NRP1

SOURCE GeneReport for Unigene cluster for NRP1 Gene:

Hs.131704

mRNA Expression by UniProt/SwissProt for NRP1 Gene:

O14786-NRP1_HUMAN
Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Evidence on tissue expression from TISSUES for NRP1 Gene

  • Kidney(4.6)
  • Muscle(4.5)
  • Liver(4.4)
  • Bone marrow(4.3)
  • Nervous system(4.3)
  • Heart(3.2)
  • Lung(3.1)
  • Spleen(2.9)
  • Lymph node(2.6)
  • Blood(2.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with NRP1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRP1 Gene

Orthologs for NRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRP1 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia NRP1 34 35
  • 91.57 (n)
cow
(Bos Taurus)
Mammalia NRP1 34 35
  • 90.58 (n)
oppossum
(Monodelphis domestica)
Mammalia NRP1 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrp1 34
  • 87.74 (n)
mouse
(Mus musculus)
Mammalia Nrp1 34 16 35
  • 87.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NRP1 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRP1 34 35
  • 78.21 (n)
lizard
(Anolis carolinensis)
Reptilia NRP1 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrp1 34
  • 71.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397804 34
zebrafish
(Danio rerio)
Actinopterygii nrp1a 34 35
  • 66.25 (n)
nrp1b 35
  • 51 (a)
OneToMany
nrp1 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7396 35
  • 23 (a)
OneToMany
Species where no ortholog for NRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRP1 Gene

ENSEMBL:
Gene Tree for NRP1 (if available)
TreeFam:
Gene Tree for NRP1 (if available)

Paralogs for NRP1 Gene

Variants for NRP1 Gene

Sequence variations from dbSNP and Humsavar for NRP1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs875989818 Uncertain significance 33,330,706(-) GCAAG(G/T)AAGTG splice-donor-variant
rs1000002801 -- 33,293,342(+) ACAGG(A/G)GCCTC intron-variant
rs1000016611 -- 33,266,124(+) TTCTC(C/T)TTCTT intron-variant
rs1000025753 -- 33,270,918(+) CAATA(A/G)TTTAG intron-variant
rs1000049792 -- 33,322,709(+) CACCA(A/G)TTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRP1 Gene

Variant ID Type Subtype PubMed ID
dgv393n106 CNV deletion 24896259
esv2662402 CNV deletion 23128226
esv2678844 CNV deletion 23128226
esv27085 CNV loss 19812545
esv2735262 CNV deletion 23290073
esv3546134 CNV deletion 23714750
esv3622850 CNV loss 21293372
esv4611 CNV loss 18987735
esv8432 CNV loss 19470904
nsv1068297 CNV deletion 25765185
nsv1133985 CNV deletion 24896259
nsv24782 CNV deletion 16902084
nsv528133 CNV loss 19592680
nsv6299 CNV insertion 18451855
nsv825336 CNV loss 20364138
nsv831829 CNV loss 17160897

Variation tolerance for NRP1 Gene

Residual Variation Intolerance Score: 9.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRP1 Gene

Human Gene Mutation Database (HGMD)
NRP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP1 Gene

Disorders for NRP1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for NRP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute hemorrhagic leukoencephalitis
  • acute haemorrhagic leucoencephalitis of weston hurst
angiomatous meningioma
brachial plexus lesion
  • brachial plexus lesions
exudative vitreoretinopathy 1
  • retinopathy of prematurity
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards
Search NRP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRP1

Genetic Association Database (GAD)
NRP1
Human Genome Epidemiology (HuGE) Navigator
NRP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRP1
genes like me logo Genes that share disorders with NRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRP1 Gene

Publications for NRP1 Gene

  1. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. (PMID: 9529250) Soker S. … Klagsbrun M. (Cell 1998) 2 3 4 22 64
  2. Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes. (PMID: 18785001) Schneider B.P. … Sledge G.W. (Breast Cancer Res. Treat. 2009) 3 22 46 64
  3. The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer. (PMID: 18638267) Nagy N. … SzAcll M. (Wound Repair Regen 2008) 3 22 46 64
  4. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. (PMID: 21682944) Alkelai A. … Lerer B. (Int. J. Neuropsychopharmacol. 2012) 3 46 64
  5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva L.K. … Teixeira M.G. (Eur. J. Hum. Genet. 2010) 3 46 64

Products for NRP1 Gene

Sources for NRP1 Gene

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