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Aliases for NRON Gene

Subcategory (RNA class) for NRON Gene

lncRNA

Quality Score for this RNA gene is

4.2

Aliases for NRON Gene

  • Non-Protein Coding RNA, Repressor Of NFAT 2 3 5
  • Noncoding Repressor Of NFAT 2 3
  • Non-Protein Coding RNA 194 2
  • NCRNA00194 3

External Ids for NRON Gene

ORGUL Members for NRON Gene

Previous GeneCards Identifiers for NRON Gene

  • GC00U921663
  • GC09U901411
  • GC09M129172
  • GC09M129175
  • GC09M129178

Summaries for NRON Gene

GeneCards Summary for NRON Gene

NRON (Non-Protein Coding RNA, Repressor Of NFAT) is an RNA Gene, and is affiliated with the lncRNA class.

fRNAdb sequence ontologies for NRON Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for NRON

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for NRON Gene

Genomics for NRON Gene

Regulatory Elements for NRON Gene

Enhancers for NRON Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F126410 1.5 FANTOM5 Ensembl ENCODE 0.8 -1.7 -1721 3.2 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 MVB12B ZBTB34 NRON GC09P126427
GH09F126403 0.8 Ensembl 0.4 +7.3 7303 0.4 ZNF121 ATF3 CEBPB ZNF24 MVB12B ENSG00000252985 NRON
GH09F126422 1.1 FANTOM5 Ensembl ENCODE 0.4 -12.8 -12797 1.0 HDGF ESRRA TSC22D4 CDC5L FOSL1 CTBP1 GATA3 NCOR1 RCOR1 FOS LOC101929116 MVB12B ZBTB34 GC09P126427 NRON
GH09F126395 1.2 Ensembl ENCODE 0.4 +14.9 14903 0.4 JUND JUN FOS ZEB1 MVB12B ENSG00000252985 NRON
GH09F126420 1 Ensembl ENCODE 0.4 -11.1 -11112 1.6 RING1 ATF1 ZMYM3 ZIC2 ZKSCAN1 ZNF23 ZMIZ1 FOSL2 FOS CREM MVB12B GC09P126427 NRON
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NRON on UCSC Golden Path with GeneCards custom track

Genomic Location for NRON Gene

Chromosome:
9
Start:
126,407,775 bp from pter
End:
126,410,504 bp from pter
Size:
2,730 bases
Orientation:
Minus strand

Genomic View for NRON Gene

Genes around NRON on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRON Gene

ORGUL Member Location for NRON Gene

ORGUL Member Location for NRON gene

Proteins for NRON Gene

Post-translational modifications for NRON Gene

No Post-translational modifications

No data available for DME Specific Peptides for NRON Gene

Domains & Families for NRON Gene

Gene Families for NRON Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRON: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NRON Gene

Function for NRON Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRON Gene

Localization for NRON Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRON Gene COMPARTMENTS Subcellular localization image for NRON gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NRON Gene

Pathways & Interactions for NRON Gene

SuperPathways for NRON Gene

No Data Available

Interacting Proteins for NRON Gene

Gene Ontology (GO) - Biological Process for NRON Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NRON Gene

Transcripts for NRON Gene

fRNAdb Secondary structures for NRON Gene

  • FR077125
  • NONHSAG053456

mRNA/cDNA for NRON Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NRON Gene

No ASD Table

Relevant External Links for NRON Gene

GeneLoc Exon Structure for
NRON
ECgene alternative splicing isoforms for
NRON

Expression for NRON Gene

mRNA expression in normal human tissues for NRON Gene

NURSA nuclear receptor signaling pathways regulating expression of NRON Gene:

NRON

SOURCE GeneReport for Unigene cluster for NRON Gene:

Hs.742606
genes like me logo Genes that share expression patterns with NRON: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NRON Gene

Orthologs for NRON Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRON Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRON 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRON 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRON 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nron 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRON 35 35
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NRON 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRON 35
  • 83 (a)
OneToOne
Species where no ortholog for NRON was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NRON Gene

ENSEMBL:
Gene Tree for NRON (if available)
TreeFam:
Gene Tree for NRON (if available)

Paralogs for NRON Gene

No data available for Paralogs for NRON Gene

Variants for NRON Gene

Sequence variations from dbSNP and Humsavar for NRON Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10987268 -- 126,407,702(+) CTACG(A/G)CATGT intron-variant, downstream-variant-500B
rs10987269 -- 126,407,963(+) GGCCA(A/G)GGAAG intron-variant, nc-transcript-variant
rs10987270 -- 126,408,964(+) GCGCC(C/T)ACCTT intron-variant, nc-transcript-variant
rs10987271 -- 126,410,968(+) CTGCA(A/G)CCTCC intron-variant, upstream-variant-2KB
rs111315649 -- 126,412,116(+) AGAGC(A/G)GGCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRON Gene

Variant ID Type Subtype PubMed ID
esv3621766 CNV gain 21293372

Relevant External Links for NRON Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRON

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NRON Gene

Disorders for NRON Gene

Relevant External Links for NRON

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRON

No disorders were found for NRON Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRON Gene

Publications for NRON Gene

  1. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. (PMID: 16141075) Willingham A.T. … Schultz P.G. (Science 2005) 1 2 3 64
  2. The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. (PMID: 25728138) Imam H. … Jameel S. (Sci Rep 2015) 3 64
  3. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. (PMID: 21983832) Liu Z. … Lenardo M.J. (Nat. Immunol. 2011) 3 64
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 64
  5. Identification and classification of conserved RNA secondary structures in the human genome. (PMID: 16628248) Pedersen J.S. … Haussler D. (PLoS Comput. Biol. 2006) 1

Products for NRON Gene

Sources for NRON Gene

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