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Aliases for NRON Gene

Subcategory (RNA class) for NRON Gene

lncRNA

Quality Score for this RNA gene is

4.2

Aliases for NRON Gene

  • Non-Protein Coding RNA, Repressor Of NFAT 2 3 5
  • Noncoding Repressor Of NFAT 2 3
  • Non-Protein Coding RNA 194 2
  • NCRNA00194 3

External Ids for NRON Gene

Previous GeneCards Identifiers for NRON Gene

  • GC00U921663
  • GC09U901411
  • GC09M129172
  • GC09M129175
  • GC09M129178

Summaries for NRON Gene

GeneCards Summary for NRON Gene

NRON (Non-Protein Coding RNA, Repressor Of NFAT) is an RNA Gene, and is affiliated with the lncRNA class.

fRNAdb sequence ontologies for NRON Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for NRON

Additional gene information for NRON Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for NRON Gene

Genomics for NRON Gene

Regulatory Elements for NRON Gene

Enhancers for NRON Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H126410 1.2 Ensembl ENCODE dbSUPER 0.7 -1.1 -1107 1 PKNOX1 TBL1XR1 SIN3A RELA ATF7 RUNX3 IKZF2 MAZ NR2F1 CBFB MVB12B NRON GC09P126427
GH09H126371 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +35.6 35577 5 ELF3 FOXA2 MLX ZFP64 ARID4B DMAP1 DNMT3B RARA MIXL1 EGR2 MVB12B ENSG00000252985 NRON
GH09H126398 1.1 ENCODE dbSUPER 0.4 +11.8 11838 0 CTCF RB1 MAX ARID4B ZNF2 RAD21 TEAD3 CTBP1 SMC3 ZNF143 ENSG00000252985 MVB12B NRON
GH09H126413 0.6 FANTOM5 0.7 -3.0 -3004 0 ZNF316 ZSCAN4 MAFG NFE2 EMSY MVB12B ZBTB34 NRON GC09P126427
GH09H126423 1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -12.8 -12777 0 MVB12B ZBTB34 GC09P126427 NRON
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRON on UCSC Golden Path with GeneCards custom track

Genomic Location for NRON Gene

Chromosome:
9
Start:
126,407,775 bp from pter
End:
126,410,504 bp from pter
Size:
2,730 bases
Orientation:
Minus strand

Genomic View for NRON Gene

Genes around NRON on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRON Gene

ORGUL Member Location for NRON Gene

ORGUL Member Location for NRON gene

Proteins for NRON Gene

Post-translational modifications for NRON Gene

No Post-translational modifications

No data available for DME Specific Peptides for NRON Gene

Domains & Families for NRON Gene

Gene Families for NRON Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRON: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NRON Gene

Function for NRON Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for NRON
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRON Gene

Localization for NRON Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRON gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NRON Gene

Pathways & Interactions for NRON Gene

No Data Available

Interacting Proteins for NRON Gene

Gene Ontology (GO) - Biological Process for NRON Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NRON Gene

Drugs & Compounds for NRON Gene

No Compound Related Data Available

Transcripts for NRON Gene

fRNAdb Secondary structures for NRON Gene

  • FR077125
  • NONHSAG053456

mRNA/cDNA for NRON Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for NRON
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NRON Gene

No ASD Table

Relevant External Links for NRON Gene

GeneLoc Exon Structure for
NRON
ECgene alternative splicing isoforms for
NRON

Expression for NRON Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRON Gene

NURSA nuclear receptor signaling pathways regulating expression of NRON Gene:

NRON

SOURCE GeneReport for Unigene cluster for NRON Gene:

Hs.742606
genes like me logo Genes that share expression patterns with NRON: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRON Gene

Orthologs for NRON Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRON Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRON 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRON 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRON 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nron 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRON 34 34
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NRON 34
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRON 34
  • 83 (a)
OneToOne
Species where no ortholog for NRON was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NRON Gene

ENSEMBL:
Gene Tree for NRON (if available)
TreeFam:
Gene Tree for NRON (if available)

Paralogs for NRON Gene

No data available for Paralogs for NRON Gene

Variants for NRON Gene

Sequence variations from dbSNP and Humsavar for NRON Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001179961 -- 126,411,274(+) TTTAC(A/T)TTGTG intron-variant, upstream-variant-2KB
rs1001413419 -- 126,411,782(+) TTAAA(A/G)TAACT intron-variant, upstream-variant-2KB
rs1001466712 -- 126,411,410(+) ACAAT(A/T)AAAAA intron-variant, upstream-variant-2KB
rs1001494243 -- 126,407,493(+) GGAGG(A/G)CGTCA intron-variant, downstream-variant-500B
rs1001990752 -- 126,407,479(+) TTTGT(C/G)ACTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NRON Gene

Variant ID Type Subtype PubMed ID
esv3621766 CNV gain 21293372

Relevant External Links for NRON Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRON

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NRON Gene

Disorders for NRON Gene

Relevant External Links for NRON

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRON

No disorders were found for NRON Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRON Gene

Publications for NRON Gene

  1. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. (PMID: 16141075) Willingham AT … Schultz PG (Science (New York, N.Y.) 2005) 1 2 3 60
  2. Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure. (PMID: 28296001) Xuan L … Yang BF (Journal of cellular and molecular medicine 2017) 3 60
  3. Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation. (PMID: 27291871) Li J … Zhang H (Nature communications 2016) 3 60
  4. The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. (PMID: 25728138) Imam H … Jameel S (Scientific reports 2015) 3 60
  5. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. (PMID: 21983832) Liu Z … Lenardo MJ (Nature immunology 2011) 3 60

Products for NRON Gene

Sources for NRON Gene

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