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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NRN1L Gene

protein-coding   GIFtS: 40
GCID: GC16P067918

Neuritin 1-Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuritin 1-Like1 2
MRCC24462
UNQ24462
Neuritin-Like Protein2

External Ids:    HGNC: 298111   Entrez Gene: 1239042   Ensembl: ENSG000001880387   UniProtKB: Q496H83   

Export aliases for NRN1L gene to outside databases

Previous GC identifers: GC16P066478 GC16P053791


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NRN1L Gene: 
NRN1L (neuritin 1-like) is a protein-coding gene. Diseases associated with NRN1L include neuronitis. An important paralog of this gene is NRN1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NRN1L gene promoter:
         NF-1   NF-1/L   SREBP-1c   CUTL1   E47   SREBP-1b   PPAR-alpha   HEN1   SREBP-1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRN1L promoter sequence
   Search SABiosciences Chromatin IP Primers for NRN1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRN1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

NRN1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRN1L gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067918:  view genomic region     (about GC identifiers)

Start:
67,918,708 bp from pter      End:
67,922,758 bp from pter
Size:
4,051 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NRN1L_HUMAN, Q496H8 (See protein sequence)
Recommended Name: Neuritin-like protein precursor  
Size: 165 amino acids; 17786 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
Secondary accessions: Q6UWH7

Explore the universe of human proteins at neXtProt for NRN1L: NX_Q496H8

Explore proteomics data for NRN1L at MOPED 

NRN1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

NRN1L Protein Expression

REFSEQ proteins: NP_940845.1  
ENSEMBL proteins: 
 ENSP00000342411   ENSP00000459748   ENSP00000464568  

Human Recombinant Protein Products for NRN1L: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0031225anchored to membrane IEA--

NRN1L for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for NRN1L


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026144 Neuritin_fam

Graphical View of Domain Structure for InterPro Entry Q496H8

ProtoNet protein and cluster: Q496H8

UniProtKB/Swiss-Prot: NRN1L_HUMAN, Q496H8
Similarity: Belongs to the neuritin family


NRN1L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nrn1l):
 normal 

NRN1L for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for NRN1L 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRN1L

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007399nervous system development IEA--

NRN1L for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NRN1L

Search CenterWatch for drugs/clinical trials and news about NRN1L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NRN1L gene: 
NM_198443.1  

Unigene Cluster for NRN1L:

Neuritin 1-like
Hs.435464  [show with all ESTs]
Unigene Representative Sequence: CD049026
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000339176(uc002euu.3) ENST00000576758 ENST00000576147
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AY358782.1 BC100863.2 BC100864.1 BC100865.1 BC100866.2 

4 DOTS entries:

DT.40197268  DT.99979772  DT.92018122  DT.99977681 

24/250 AceView cDNA sequences (see all 250):

BM829412 AW008559 BG152495 BM904759 AL547368 CA392269 BP365234 BX343656 
AI880232 Z41467 CA392332 BU181407 AA581635 BE267681 AK128582 NM_198443 
BG392209 BU625527 BU540877 BQ084297 AY358782 BC053598 CD674788 BQ226185 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NRN1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCCCTGCGC
NRN1L Expression
About this image


See NRN1L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.435464
    SABiosciences Custom PCR Arrays for NRN1L
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRN1L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NRN1L gene from 3/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nrn1l1 , 5 neuritin 1-like1, 5 76.37(n)1
80.38(a)1
  8 (53.06 cM)5
2347001  NM_175024.31  NP_778189.11 
 1058935675 
lizard
(Anolis carolinensis)
Reptilia NRN1L6
Uncharacterized protein
36(a)
1 ↔ 1
GL343295.1(531351-536517)
zebrafish
(Danio rerio)
Actinopterygii nrn1la6
nrn1lb6
neuritin 1-like b
34(a)
33(a)
1 ↔ many
1 ↔ many
18(21564830-21639509)
7(30354006-30358108)


ENSEMBL Gene Tree for NRN1L (if available)
TreeFam Gene Tree for NRN1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NRN1L gene
NRN12  
1 SIMAP similar gene for NRN1L using alignment to 3 protein entries:     NRN1L_HUMAN (see all proteins):
NRN1

NRN1L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/60 SNPs in NRN1L are shown (see all 60)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs563581361,2
C,F--67919216(+) AAAATA/GTTTAT 1 -- int14Minor allele frequency- G:0.21WA CSA 124
rs791492571,2
C,F--67919362(+) ACCTGC/TGGCCC 1 -- int12Minor allele frequency- T:0.19CSA WA 120
rs124474251,2
C,F,H--67919535(+) TGCTCC/TCAGGT 1 -- int19Minor allele frequency- T:0.01NS EA NA 608
rs1156665751,2
C,F--67919656(+) GCAGCG/CGGCCC 2 /A syn12Minor allele frequency- C:0.00WA NA 4570
rs2016036621,2
C--67919679(+) CACCAC/TATACC 2 T I mis10--------
rs1508981091,2
F--67919695(+) TTCGCC/TGAGTG 2 A syn11Minor allele frequency- G:0.00NA 4536
rs1397762381,2
F--67919696(+) TCGCCG/AAGTGT 2 /K /E mis11Minor allele frequency- A:0.00NA 4536
rs1443619851,2
C,F--67919730(+) GGGCCG/TCGGAG 2 R L mis11Minor allele frequency- T:0.00NA 4528
rs1833349891,2
--67919731(+) GGCCGA/CGGAGG 2 R syn10--------
rs2011700671,2
C,F--67919766(+) CCGGCG/AGGTGT 1 -- int11Minor allele frequency- A:0.00EU 959

HapMap Linkage Disequilibrium report for NRN1L (67918708 - 67922758 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for NRN1L:    About this table     
Variant IDTypeSubtypePubMed ID
nsv1844CNV Loss18451855
nsv906813CNV Loss21882294
nsv524363CNV Loss19592680
nsv906814CNV Loss21882294
nsv522852CNV Gain19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for NRN1L:    About MalaCards
neuronitis    


NRN1L for disorders           About GeneDecksing

Genetic Association Database (GAD): NRN1L

Export disorders for NRN1L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NRN1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with NRN1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
  2. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PubMed id 18265009)1 Fujino T....Nedivi E. (2008)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 123904 HGNC: 29811 AceView: RCD-8andUNQ2446 Ensembl:ENSG00000188038 euGenes: HUgn123904
ECgene: NRN1L H-InvDB: NRN1L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for NRN1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for NRN1L gene:
Search GeneIP for patents involving NRN1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for NRN1L
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRN1L
 inGenious Targeting Laboratory - Custom generated mouse model solutions for NRN1L
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NRN1L
Customized:
 lentivirus for stable overexpression of NRN1L
 lentivirus expression plasmids for stable overexpression of NRN1L
 adenovirus for overexpression of NRN1L
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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