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Aliases for NRN1L Gene

Aliases for NRN1L Gene

  • Neuritin 1 Like 2 3
  • Neuritin 1-Like 3 5
  • MRCC2446 3
  • UNQ2446 3

External Ids for NRN1L Gene

Previous GeneCards Identifiers for NRN1L Gene

  • GC16P066478
  • GC16P067918
  • GC16P053791

Summaries for NRN1L Gene

GeneCards Summary for NRN1L Gene

NRN1L (Neuritin 1 Like) is a Protein Coding gene. An important paralog of this gene is NRN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRN1L Gene

Genomics for NRN1L Gene

Regulatory Elements for NRN1L Gene

Genomic Location for NRN1L Gene

67,884,805 bp from pter
67,888,855 bp from pter
4,051 bases
Plus strand

Genomic View for NRN1L Gene

Genes around NRN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRN1L Gene

Proteins for NRN1L Gene

  • Protein details for NRN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuritin-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6UWH7

    Protein attributes for NRN1L Gene

    165 amino acids
    Molecular mass:
    17786 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRN1L Gene

Proteomics data for NRN1L Gene at MOPED

Post-translational modifications for NRN1L Gene

No Post-translational modifications

Other Protein References for NRN1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRN1L Gene

Domains & Families for NRN1L Gene

Protein Domains for NRN1L Gene


Suggested Antigen Peptide Sequences for NRN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neuritin family.
  • Belongs to the neuritin family.
genes like me logo Genes that share domains with NRN1L: view

No data available for Gene Families for NRN1L Gene

Function for NRN1L Gene

Phenotypes for NRN1L Gene

MGI mutant phenotypes for NRN1L:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NRN1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NRN1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRN1L Gene

Localization for NRN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRN1L Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for NRN1L Gene COMPARTMENTS Subcellular localization image for NRN1L gene
Compartment Confidence
plasma membrane 4
extracellular 3

Gene Ontology (GO) - Cellular Components for NRN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0046658 anchored component of plasma membrane IEA --
genes like me logo Genes that share ontologies with NRN1L: view

Pathways & Interactions for NRN1L Gene

SuperPathways for NRN1L Gene

No Data Available

Interacting Proteins for NRN1L Gene

Gene Ontology (GO) - Biological Process for NRN1L Gene


No data available for Pathways by source and SIGNOR curated interactions for NRN1L Gene

Drugs & Compounds for NRN1L Gene

No Compound Related Data Available

Transcripts for NRN1L Gene

mRNA/cDNA for NRN1L Gene

Unigene Clusters for NRN1L Gene

Neuritin 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRN1L Gene

No ASD Table

Relevant External Links for NRN1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRN1L Gene

mRNA expression in normal human tissues for NRN1L Gene

SOURCE GeneReport for Unigene cluster for NRN1L Gene Hs.435464

genes like me logo Genes that share expression patterns with NRN1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NRN1L Gene

Orthologs for NRN1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRN1L Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NRN1L 35
  • 74.3 (n)
  • 70.99 (a)
(Mus musculus)
Mammalia Nrn1l 35
  • 82.49 (n)
  • 87.88 (a)
Nrn1l 16
Nrn1l 36
  • 75 (a)
(Pan troglodytes)
Mammalia NRN1L 35
  • 98.92 (n)
  • 98.39 (a)
NRN1L 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Nrn1l 35
  • 83.16 (n)
  • 85.86 (a)
(Gallus gallus)
Aves -- 36
  • 30 (a)
(Anolis carolinensis)
Reptilia NRN1L 36
  • 40 (a)
(Danio rerio)
Actinopterygii nrn1la 36
  • 34 (a)
nrn1lb 36
  • 35 (a)
Species with no ortholog for NRN1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRN1L Gene

Gene Tree for NRN1L (if available)
Gene Tree for NRN1L (if available)

Paralogs for NRN1L Gene

Paralogs for NRN1L Gene

(1) SIMAP similar genes for NRN1L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NRN1L: view

Variants for NRN1L Gene

Sequence variations from dbSNP and Humsavar for NRN1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs79149257 -- 67,885,459(+) ACCTG(C/T)GGCCC intron-variant
rs138120680 -- 67,886,178(+) ACAGC(A/G)CCTGC reference, synonymous-codon
rs73593844 -- 67,886,027(+) TCCGG(A/C)GGAGG reference, missense
rs73594554 -- 67,886,146(+) GCTCC(A/G)AAACC reference, missense
rs144361985 -- 67,885,827(+) GGGCC(A/G/T)CGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NRN1L Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906813 CNV Loss 21882294
nsv1844 CNV Loss 18451855
nsv906814 CNV Loss 21882294

Variation tolerance for NRN1L Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NRN1L Gene

Disorders for NRN1L Gene

Relevant External Links for NRN1L

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NRN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRN1L Gene

Publications for NRN1L Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  3. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PMID: 18265009) Fujino T. … Nedivi E. (J. Comp. Neurol. 2008) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for NRN1L Gene

Sources for NRN1L Gene