NRN1L Gene
protein-coding GIFtS: 37
GCID: GC16P067918
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neuritin 1-like
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Aliases
for NRN1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuritin 1-Like1 2 | | MRCC24461 2 | | UNQ24461 2 | | Neuritin-Like Protein2 |
Export aliases for NRN1L gene to outside databasesPrevious GC identifers: GC16P066478 GC16P053791 |
Summaries
for NRN1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NRN1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NRN1L gene promoter:
NF-1 NF-1/L SREBP-1c CUTL1 E47 SREBP-1b PPAR-alpha HEN1 SREBP-1a Hand1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NRN1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRN1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1NRN1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P067918: view genomic region
(about GC identifiers)
Start:
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67,918,708 bp from pter |
End:
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67,922,758 bp from pter |
Size:
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4,051 bases |
Orientation:
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plus strand |
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Proteins
for NRN1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NRN1L_HUMAN, Q496H8 (See
protein sequence)Recommended Name: Neuritin-like protein precursor Size: 165 amino acids; 17786 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
Secondary accessions: Q6UWH7Explore the universe of human proteins at neXtProt for NRN1L: NX_Q496H8
NRN1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940845.1
ENSEMBL proteins: ENSP00000342411 ENSP00000459748 ENSP00000464568
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0031225 | anchored to membrane |
IEA | -- |
NRN1L for ontologies About GeneDecksing
NRN1L Antibody Products:
Assay Products for NRN1L: |
Protein
Domains /
Families
for NRN1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NRN1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q496H8ProtoNet protein and cluster: Q496H8 UniProtKB/Swiss-Prot: NRN1L_HUMAN, Q496H8Similarity: Belongs to the neuritin family |
Function
for NRN1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRN1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRN1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NRN1L (NM_198443) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRN1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRN1L |
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Nrn1l):
NRN1L for phenotypes About GeneDecksing
|
Pathways & Interactions
for NRN1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRN1L
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007399 | nervous system development |
IEA | -- |
NRN1L for ontologies About GeneDecksing
|
Drugs & Compounds
for NRN1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NRN1L
Search CenterWatch for drugs/clinical trials and news about NRN1L
|
Transcripts
for NRN1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NRN1L gene: NM_198443.1 Unigene Cluster for NRN1L: Neuritin 1-like Hs.435464 [show with all ESTs]Unigene Representative Sequence: CD0490263 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339176(uc002euu.3) ENST00000576758 ENST00000576147
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRN1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRN1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NRN1L (NM_198443) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRN1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRN1L |
Additional cDNA sequence: AY358782.1 BC100863.2 BC100864.1 BC100865.1 BC100866.2 4 DOTS entries: DT.40197268 DT.99979772 DT.92018122 DT.99977681 24/250 AceView cDNA sequences (see all 250): BQ226185 AW008559 BM454289 BM829412 BC064567 CA392269 NM_198443 AI880232 BP365234 BG743470 BX377984 AL557520 BE886384 AA581635 NM_014329 BQ229187 Z41467 BC043616 BX343656 CR618363 BE933369 BG392209 BM722884 BM464234
GeneLoc Exon Structure
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Expression
for NRN1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NRN1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCCTGCGC
About this image
See NRN1L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.435464
SABiosciences Custom PCR Arrays for NRN1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRN1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NRN1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRN1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRN1L |
Orthologs
for NRN1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NRN1L gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for NRN1L (if available)
TreeFam Gene Tree for NRN1L (if available) |
Paralogs
for NRN1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NRN1L gene
- NRN12
1 SIMAP similar gene for NRN1L using alignment to 3 protein entries: NRN1L_HUMAN (see all proteins):NRN1
NRN1L for paralogs About GeneDecksing
|
Genomic Variants
for NRN1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NRN1L (67918708 - 67922758 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NRN1L
1 CNV: 35395 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRN1L |
|
Disorders
/ Diseases
for NRN1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NRN1L for disorders About GeneDecksing
1  disease for NRN1L: About MalaCardsneuronitis
Export disorders for NRN1L gene to outside databases
|
Publications
for NRN1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NRN1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with NRN1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PubMed id 18265009)1 Fujino T....Nedivi E. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NRN1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NRN1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NRN1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NRN1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NRN1L | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NRN1L gene:
Search GeneIP for patents involving NRN1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NRN1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NRN1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRN1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRN1L | | | OriGene Protein Over-expression Lysate for NRN1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NRN1L | | OriGene 3'-UTR Clone for NRN1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRN1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRN1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NRN1L | | OriGene Custom Protein Services for NRN1L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NRN1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRN1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRN1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRN1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRN1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRN1L |
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 | | | NRN1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for NRN1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRN1L |
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