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NRN1L Gene

protein-coding   GIFtS: 40
GCID: GC16P067918

Neuritin 1-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuritin 1-Like1 2
MRCC24462
UNQ24462
Neuritin-Like Protein2

External Ids:    HGNC: 298111   Entrez Gene: 1239042   Ensembl: ENSG000001880387   UniProtKB: Q496H83   

Export aliases for NRN1L gene to outside databases

Previous GC identifers: GC16P066478 GC16P053791


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NRN1L Gene:
NRN1L (neuritin 1-like) is a protein-coding gene. An important paralog of this gene is NRN1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRN1L gene promoter:
         NF-1   NF-1/L   SREBP-1c   CUTL1   E47   SREBP-1b   PPAR-alpha   HEN1   SREBP-1a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRN1L promoter sequence
   Search Chromatin IP Primers for NRN1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRN1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

NRN1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRN1L gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067918:  view genomic region     (about GC identifiers)

Start:
67,918,708 bp from pter      End:
67,922,758 bp from pter
Size:
4,051 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NRN1L_HUMAN, Q496H8 (See protein sequence)
Recommended Name: Neuritin-like protein precursor  
Size: 165 amino acids; 17786 Da
Secondary accessions: Q6UWH7

Explore the universe of human proteins at neXtProt for NRN1L: NX_Q496H8

REFSEQ proteins: NP_940845.1  
ENSEMBL proteins: 
 ENSP00000342411   ENSP00000459748   ENSP00000464568  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR026144 Neuritin_fam

Graphical View of Domain Structure for InterPro Entry Q496H8

ProtoNet protein and cluster: Q496H8

UniProtKB/Swiss-Prot: NRN1L_HUMAN, Q496H8
Similarity: Belongs to the neuritin family


Find genes that share domains with NRN1L           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nrn1l):
 normal 

Find genes that share phenotypes with NRN1L           About GenesLikeMe

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NRN1L_HUMAN, Q496H8: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
extracellular3

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0031225anchored component of membrane IEA--

Find genes that share ontologies with NRN1L           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for NRN1L

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007399nervous system development IEA--

Find genes that share ontologies with NRN1L           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for NRN1L



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NRN1L gene: 
NM_198443.1  

Unigene Cluster for NRN1L:

Neuritin 1-like
Hs.435464  [show with all ESTs]
Unigene Representative Sequence: CD049026
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000339176(uc002euu.3) ENST00000576758 ENST00000576147
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Additional mRNA sequence: 

AY358782.1 BC100863.2 BC100864.1 BC100865.1 BC100866.2 

4 DOTS entries:

DT.40197268  DT.99979772  DT.92018122  DT.99977681 

Selected AceView cDNA sequences (see all 250):

CR618363 CF131585 AL547368 BG743470 BQ002387 BU181407 BU521280 Z41467 
AL557520 BQ084297 AI811269 AK128582 BC043616 AI880232 BF432145 BQ229187 
BM904759 BM464234 BC053598 BU195214 BG152495 BX377983 BE296550 BX343656 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NRN1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCCCTGCGC
NRN1L Expression
About this image

NRN1L Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.435464
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NRN1L gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nrn1l1 , 5 neuritin 1-like1, 5 82.49(n)1
87.88(a)1
  8 (53.06 cM)5
2347001  NM_175024.31  NP_778189.11 
 1058935675 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
30(a)
many ↔ many
20(5458592-5461795)
lizard
(Anolis carolinensis)
Reptilia NRN1L6
neuritin 1-like
40(a)
1 ↔ 1
GL343295.1(531351-536517)
zebrafish
(Danio rerio)
Actinopterygii nrn1lb6
nrn1la6
neuritin 1-like a
35(a)
34(a)
1 ↔ many
1 ↔ many
7(30354006-30358108) ENSDARG00000061149
18(21564830-21639509) ENSDARG00000069368


ENSEMBL Gene Tree for NRN1L (if available)
TreeFam Gene Tree for NRN1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NRN1L gene
NRN12  
1 SIMAP similar gene for NRN1L using alignment to 3 protein entries:     NRN1L_HUMAN (see all proteins):
NRN1

Find genes that share paralogs with NRN1L           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NRN1L (see all 60)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs563581361,2
C,F--67919216(+) AAAATA/GTTTAT 1 -- int14Minor allele frequency- G:0.21WA CSA 124
rs791492571,2
C,F--67919362(+) ACCTGC/TGGCCC 1 -- int12Minor allele frequency- T:0.19CSA WA 120
rs124474251,2
C,F,H--67919535(+) TGCTCC/TCAGGT 1 -- int19Minor allele frequency- T:0.01NS EA NA 608
rs1156665751,2
C,F--67919656(+) GCAGCG/CGGCCC 2 /A syn12Minor allele frequency- C:0.00WA NA 4570
rs2016036621,2
C--67919679(+) CACCAC/TATACC 2 T I mis10--------
rs1508981091,2
F--67919695(+) TTCGCC/TGAGTG 2 A syn11Minor allele frequency- G:0.00NA 4536
rs1397762381,2
F--67919696(+) TCGCCG/AAGTGT 2 /K /E mis11Minor allele frequency- A:0.00NA 4536
rs1443619851,2
C,F--67919730(+) GGGCCG/TCGGAG 2 R L mis11Minor allele frequency- T:0.00NA 4528
rs1833349891,2
--67919731(+) GGCCGA/CGGAGG 2 R syn10--------
rs2011700671,2
C,F--67919766(+) CCGGCG/AGGTGT 1 -- int11Minor allele frequency- A:0.00EU 959

HapMap Linkage Disequilibrium report for NRN1L (67918708 - 67922758 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for NRN1L:    About this table    
Variant IDTypeSubtypePubMed ID
nsv1844CNV Loss18451855
nsv906813CNV Loss21882294
nsv524363CNV Loss19592680
nsv906814CNV Loss21882294
nsv522852CNV Gain19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with NRN1L           About GenesLikeMe

Genetic Association Database (GAD): NRN1L

Export disorders for NRN1L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NRN1L gene integrated from 10 sources:
(articles sorted by number of sources associating them with NRN1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
  2. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PubMed id 18265009)1 Fujino T....Nedivi E. (J. Comp. Neurol. 2008)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 123904 HGNC: 29811 AceView: RCD-8andUNQ2446 Ensembl:ENSG00000188038 euGenes: HUgn123904
ECgene: NRN1L H-InvDB: NRN1L

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NRN1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NRN1L gene:
Search GeneIP for patents involving NRN1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Proteins for NRN1L
 Antibodies for NRN1L
 ELISAs for NRN1L
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 Browse ESI BIO Cell Lines and PureStem Progenitors for NRN1L
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRN1L
 Browse SwitchGear 3'UTR luciferase reporter plasmids for NRN1L
 SwitchGear Promoter luciferase reporter plasmids for NRN1L
 Search ThermoFisher Antibodies for NRN1L
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRN1L
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRN1L
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NRN1L
 LSBio Antibodies in human, mouse, rat for NRN1L
Customized transgenic rodents for:
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 Tissue-specific gene expresssion
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 Browse compounds at ApexBio
 Search Addgene for plasmids for NRN1L
  Search eBioscience for proteins for NRN1L
  Search eBioscience for elisas for NRN1L
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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