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Aliases for NRN1 Gene

Aliases for NRN1 Gene

  • Neuritin 1 2 3 5
  • NRN 3 4
  • DJ380B8.2 3
  • Neuritin 3

External Ids for NRN1 Gene

Previous GeneCards Identifiers for NRN1 Gene

  • GC06M005983
  • GC06M005943
  • GC06M005873

Summaries for NRN1 Gene

Entrez Gene Summary for NRN1 Gene

  • This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for NRN1 Gene

NRN1 (Neuritin 1) is a Protein Coding gene. Diseases associated with NRN1 include Astrocytoma and Degenerative Myopia. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is NRN1L.

UniProtKB/Swiss-Prot for NRN1 Gene

  • Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRN1 Gene

Genomics for NRN1 Gene

Regulatory Elements for NRN1 Gene

Enhancers for NRN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F005981 0.5 Ensembl 20.8 +25.8 25805 0.4 JUND NRN1 GC06P005986 GC06P005976
GH06F005979 0.8 FANTOM5 Ensembl ENCODE 20.6 +27.5 27456 1.3 MAX NRN1 GC06P005976 GC06P005986
GH06F005988 0.8 Ensembl ENCODE 16.6 +18.0 17975 1.5 SCRT2 NRN1 GC06P005986 LOC105374898
GH06F005991 0.3 FANTOM5 14.8 +16.2 16207 0.1 NRN1 LOC105374898 GC06P005986
GH06F005995 0.9 FANTOM5 Ensembl ENCODE 11.6 +9.7 9667 4.5 PKNOX1 GLIS2 KLF7 SP3 CBX8 ZNF585B SMARCA4 GLIS1 MYNN KDM1A ENSG00000216360 NRN1 LYRM4 LOC105374898
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NRN1 on UCSC Golden Path with GeneCards custom track

Promoters for NRN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001877839 505 1401 ZNF76 KLF17 RAD21 ZNF335 GLIS2 ZNF366 ZNF207 ZNF391 EGR2 SP3

Genomic Location for NRN1 Gene

Chromosome:
6
Start:
5,997,999 bp from pter
End:
6,007,605 bp from pter
Size:
9,607 bases
Orientation:
Minus strand

Genomic View for NRN1 Gene

Genes around NRN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRN1 Gene

Proteins for NRN1 Gene

  • Protein details for NRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPD7-NRN1_HUMAN
    Recommended name:
    Neuritin
    Protein Accession:
    Q9NPD7
    Secondary Accessions:
    • B2RA93
    • Q7Z4Y1

    Protein attributes for NRN1 Gene

    Size:
    142 amino acids
    Molecular mass:
    15333 Da
    Quaternary structure:
    • Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for NRN1 Gene

Post-translational modifications for NRN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRN1 Gene

Antibody Products

No data available for DME Specific Peptides for NRN1 Gene

Domains & Families for NRN1 Gene

Protein Domains for NRN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPD7

UniProtKB/Swiss-Prot:

NRN1_HUMAN :
  • Belongs to the neuritin family.
Family:
  • Belongs to the neuritin family.
genes like me logo Genes that share domains with NRN1: view

No data available for Gene Families for NRN1 Gene

Function for NRN1 Gene

Molecular function for NRN1 Gene

UniProtKB/Swiss-Prot Function:
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.

Gene Ontology (GO) - Molecular Function for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with NRN1: view
genes like me logo Genes that share phenotypes with NRN1: view

Animal Models for NRN1 Gene

MGI Knock Outs for NRN1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRN1 Gene

Localization for NRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRN1 Gene COMPARTMENTS Subcellular localization image for NRN1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0031225 anchored component of membrane IEA --
GO:0032281 AMPA glutamate receptor complex IEA --
genes like me logo Genes that share ontologies with NRN1: view

Pathways & Interactions for NRN1 Gene

genes like me logo Genes that share pathways with NRN1: view

Gene Ontology (GO) - Biological Process for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:1990138 neuron projection extension IEA --
genes like me logo Genes that share ontologies with NRN1: view

No data available for SIGNOR curated interactions for NRN1 Gene

Transcripts for NRN1 Gene

Unigene Clusters for NRN1 Gene

Neuritin 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for NRN1 Gene

GeneLoc Exon Structure for
NRN1
ECgene alternative splicing isoforms for
NRN1

Expression for NRN1 Gene

mRNA expression in normal human tissues for NRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRN1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.5), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for NRN1 Gene

This gene is overexpressed in Cerebrospinal fluid (39.7) and Frontal cortex (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRN1 Gene



Protein tissue co-expression partners for NRN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRN1 Gene:

NRN1

SOURCE GeneReport for Unigene cluster for NRN1 Gene:

Hs.103291
genes like me logo Genes that share expression patterns with NRN1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NRN1 Gene

Orthologs for NRN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRN1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia NRN1 34 35
  • 98.12 (n)
cow
(Bos Taurus)
Mammalia NRN1 34 35
  • 97.18 (n)
mouse
(Mus musculus)
Mammalia Nrn1 34 16 35
  • 96.71 (n)
rat
(Rattus norvegicus)
Mammalia Nrn1 34
  • 96.71 (n)
oppossum
(Monodelphis domestica)
Mammalia NRN1 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves NRN1 34 35
  • 81.29 (n)
lizard
(Anolis carolinensis)
Reptilia NRN1 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrn1 34
  • 76.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia nrn1-A 34
zebrafish
(Danio rerio)
Actinopterygii nrn1a 34 35
  • 66.9 (n)
nrn1b 35
  • 50 (a)
OneToMany
Dr.29231 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11184 34
Species where no ortholog for NRN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRN1 Gene

ENSEMBL:
Gene Tree for NRN1 (if available)
TreeFam:
Gene Tree for NRN1 (if available)

Paralogs for NRN1 Gene

Paralogs for NRN1 Gene

(1) SIMAP similar genes for NRN1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NRN1 Gene

genes like me logo Genes that share paralogs with NRN1: view

Variants for NRN1 Gene

Sequence variations from dbSNP and Humsavar for NRN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1011807 -- 6,005,233(-) GAGCA(A/G)GAGAG intron-variant, upstream-variant-2KB
rs1052727 -- 5,998,159(-) TTAAT(C/T)TAAAA nc-transcript-variant, utr-variant-3-prime
rs107738 -- 6,001,895(-) TGTTT(A/G)GGGTA intron-variant
rs111285530 -- 6,002,095(+) GAGGC(C/T)GCGTA intron-variant
rs111329525 -- 6,000,659(+) CCCAG(A/G)GAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRN1 Gene

Variant ID Type Subtype PubMed ID
esv3607988 CNV gain 21293372
nsv436891 CNV insertion 17901297

Variation tolerance for NRN1 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRN1 Gene

Human Gene Mutation Database (HGMD)
NRN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRN1 Gene

Disorders for NRN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NRN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
astrocytoma
  • astrocytic tumor
degenerative myopia
  • degenerative progressive high myopia
- elite association - COSMIC cancer census association via MalaCards
Search NRN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRN1

Genetic Association Database (GAD)
NRN1
Human Genome Epidemiology (HuGE) Navigator
NRN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRN1
genes like me logo Genes that share disorders with NRN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRN1 Gene

Publications for NRN1 Gene

  1. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. (PMID: 9122250) Naeve G.S. … Theill L.E. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia. (PMID: 19569075) Chandler D. … Jablensky A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 22 46 64
  3. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PMID: 18265009) Fujino T. … Nedivi E. (J. Comp. Neurol. 2008) 3 22 64
  4. Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. (PMID: 16723126) Le Jan S. … Germain S. (FEBS Lett. 2006) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for NRN1 Gene

Sources for NRN1 Gene

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