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Aliases for NRN1 Gene

Aliases for NRN1 Gene

  • Neuritin 1 2 3 5
  • NRN 3 4
  • DJ380B8.2 3
  • Neuritin 3

External Ids for NRN1 Gene

Previous GeneCards Identifiers for NRN1 Gene

  • GC06M005983
  • GC06M005943
  • GC06M005873

Summaries for NRN1 Gene

Entrez Gene Summary for NRN1 Gene

  • This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for NRN1 Gene

NRN1 (Neuritin 1) is a Protein Coding gene. Diseases associated with NRN1 include Astrocytoma and Degenerative Myopia. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is NRN1L.

UniProtKB/Swiss-Prot for NRN1 Gene

  • Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.

Additional gene information for NRN1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRN1 Gene

Genomics for NRN1 Gene

Regulatory Elements for NRN1 Gene

Enhancers for NRN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H005979 0.9 FANTOM5 Ensembl ENCODE 20.7 +27.6 27556 1.1 MAX NRN1 GC06P005976 GC06P005986
GH06H005995 1.5 FANTOM5 Ensembl ENCODE 11.6 +9.7 9667 4.5 PKNOX1 KLF17 BMI1 GLIS2 ZNF366 RUNX3 EGR2 SP3 ZNF680 ZEB2 NRN1 ENSG00000216360 LYRM4 LOC105374898
GH06H006545 1.2 Ensembl ENCODE 11.3 -539.2 -539190 2.2 TBP HDGF PKNOX1 ATF1 RB1 SIN3A BATF ZNF2 RAD21 RFX5 NRN1 F13A1 LY86 GC06M006539
GH06H006005 1.4 FANTOM5 ENCODE 8.9 +0.1 134 4 ATF1 SIN3A ZNF2 GLIS2 ZNF143 ATF7 SP3 SP5 YY2 TSHZ1 LOC442155 NRN1 PPP1R3G LOC105374898
GH06H006003 1.1 Ensembl ENCODE 10 +3.5 3516 2 ZSCAN4 KLF17 GLI4 ZNF2 ZNF121 GLIS2 ZNF366 EGR2 REST ZNF398 NRN1 LOC105374898
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRN1 on UCSC Golden Path with GeneCards custom track

Promoters for NRN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000192610 -695 201 CBX8 ATF1 POLR2A ZNF837 ZNF512 ZNF629 SIN3A ZNF2 EZH2

Genomic Locations for NRN1 Gene

Genomic Locations for NRN1 Gene
9,607 bases
Minus strand

Genomic View for NRN1 Gene

Genes around NRN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRN1 Gene

Proteins for NRN1 Gene

  • Protein details for NRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RA93
    • Q7Z4Y1

    Protein attributes for NRN1 Gene

    142 amino acids
    Molecular mass:
    15333 Da
    Quaternary structure:
    • Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for NRN1 Gene

Post-translational modifications for NRN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRN1 Gene

Antibody Products

No data available for DME Specific Peptides for NRN1 Gene

Domains & Families for NRN1 Gene

Gene Families for NRN1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NRN1 Gene


Suggested Antigen Peptide Sequences for NRN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neuritin family.
  • Belongs to the neuritin family.
genes like me logo Genes that share domains with NRN1: view

Function for NRN1 Gene

Molecular function for NRN1 Gene

UniProtKB/Swiss-Prot Function:
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.

Phenotypes From GWAS Catalog for NRN1 Gene

Gene Ontology (GO) - Molecular Function for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with NRN1: view
genes like me logo Genes that share phenotypes with NRN1: view

Animal Models for NRN1 Gene

MGI Knock Outs for NRN1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRN1 Gene

Localization for NRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRN1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with NRN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NRN1 Gene

Pathways & Interactions for NRN1 Gene

genes like me logo Genes that share pathways with NRN1: view

Interacting Proteins for NRN1 Gene

Selected Interacting proteins: Q9NPD7-NRN1_HUMAN for NRN1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007399 nervous system development IEA --
GO:1990138 neuron projection extension IEA --
genes like me logo Genes that share ontologies with NRN1: view

No data available for SIGNOR curated interactions for NRN1 Gene

Drugs & Compounds for NRN1 Gene

No Compound Related Data Available

Transcripts for NRN1 Gene

Unigene Clusters for NRN1 Gene

Neuritin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for NRN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRN1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.5), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for NRN1 Gene

This gene is overexpressed in Cerebrospinal fluid (39.7) and Frontal cortex (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRN1 Gene

Protein tissue co-expression partners for NRN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRN1 Gene:


SOURCE GeneReport for Unigene cluster for NRN1 Gene:


Evidence on tissue expression from TISSUES for NRN1 Gene

  • Nervous system(4.9)
  • Adrenal gland(4.1)
genes like me logo Genes that share expression patterns with NRN1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRN1 Gene

Orthologs for NRN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NRN1 33 34
  • 100 (n)
(Canis familiaris)
Mammalia NRN1 33 34
  • 98.12 (n)
(Bos Taurus)
Mammalia NRN1 33 34
  • 97.18 (n)
(Mus musculus)
Mammalia Nrn1 33 16 34
  • 96.71 (n)
(Rattus norvegicus)
Mammalia Nrn1 33
  • 96.71 (n)
(Monodelphis domestica)
Mammalia NRN1 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
-- 34
  • 56 (a)
(Gallus gallus)
Aves NRN1 33 34
  • 81.29 (n)
(Anolis carolinensis)
Reptilia NRN1 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nrn1 33
  • 76.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia nrn1-A 33
(Danio rerio)
Actinopterygii nrn1a 33 34
  • 66.9 (n)
nrn1b 34
  • 50 (a)
Dr.29231 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11184 33
Species where no ortholog for NRN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRN1 Gene

Gene Tree for NRN1 (if available)
Gene Tree for NRN1 (if available)

Paralogs for NRN1 Gene

Paralogs for NRN1 Gene

(1) SIMAP similar genes for NRN1 Gene using alignment to 1 proteins: Pseudogenes for NRN1 Gene

genes like me logo Genes that share paralogs with NRN1: view

Variants for NRN1 Gene

Sequence variations from dbSNP and Humsavar for NRN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000007703 -- 5,998,955(+) GCGCG(A/C)GGGGG downstream-variant-500B, utr-variant-3-prime
rs1000040337 -- 5,998,587(+) GGAGC(C/T)CATCA nc-transcript-variant, utr-variant-3-prime
rs1000063669 -- 6,001,410(+) AGGAC(-/AG)GGGTG intron-variant
rs1000124269 -- 6,005,363(+) AAACA(A/G)CCAGA intron-variant, upstream-variant-2KB
rs1000457735 -- 6,004,229(+) ACCCT(C/T)GCGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NRN1 Gene

Variant ID Type Subtype PubMed ID
nsv436891 CNV insertion 17901297
esv3607988 CNV gain 21293372

Variation tolerance for NRN1 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRN1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRN1 Gene

Disorders for NRN1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NRN1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • astrocytic tumor
degenerative myopia
  • degenerative progressive high myopia
persistent hyperplastic primary vitreous
  • phpv
- elite association - COSMIC cancer census association via MalaCards
Search NRN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NRN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRN1 Gene

Publications for NRN1 Gene

  1. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. (PMID: 9122250) Naeve GS … Theill LE (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 60
  2. Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia. (PMID: 19569075) Chandler D … Jablensky A (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 22 45 60
  3. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PMID: 18265009) Fujino T … Nedivi E (The Journal of comparative neurology 2008) 3 22 60
  4. Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. (PMID: 16723126) Le Jan S … Germain S (FEBS letters 2006) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for NRN1 Gene

Sources for NRN1 Gene

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