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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NRN1 Gene

protein-coding   GIFtS: 50
GCID: GC06M005943

neuritin 1
 Explore 6 diseases affiliated with
NRN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NRN1    

Aliases
for NRN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neuritin 11 2
NRN1 2 3 5
DJ380B8.21
Neuritin1

External Ids:    HGNC: 179721   Entrez Gene: 512992   Ensembl: ENSG000001247857   OMIM: 6074095   UniProtKB: Q9NPD73   

Export aliases for NRN1 gene to outside databases

Previous GC identifers: GC06M005983 GC06M005873


Summaries
for NRN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NRN1:
This gene is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal
structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and
neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol
(GPI)-anchored proteins. In vitro assays demonstrated that this protein promotes neurite outgrowth and arborization,
suggesting its role in promoting neuritogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NRN1_HUMAN, Q9NPD7
Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical
cells (By similarity)




Genomic Views
for NRN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NRN1 gene promoter:
         FOXJ2 (long isoform)   Cart-1   MyoD   CUTL1   FOXJ2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NRN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NRN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.1   Ensembl cytogenetic band:  6p25.1   HGNC cytogenetic band: 6p25.1

NRN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRN1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M005943:  view genomic region     (about GC identifiers)

Start:
 5,998,232 bp from pter      End:
 6,007,633 bp from pter
Size:
 9,402 bases      Orientation:
 minus strand

Proteins
for NRN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NRN1_HUMAN, Q9NPD7 (See protein sequence)
Recommended Name: Neuritin precursor  
Size: 142 amino acids; 15333 Da
Subunit: Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming
GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One
of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors
CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents
binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core
constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of
the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in
combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact
their biogenesis and protein processing (By similarity)
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential). Cell junction, synapse (By similarity)
Secondary accessions: B2RA93 Q7Z4Y1

Explore the universe of human proteins at neXtProt for NRN1: NX_Q9NPD7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NPD7

    • NRN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057672.1  
    ENSEMBL proteins: 
     ENSP00000244766  

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    Uscn Proteins for NRN1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0030054cell junction IEA--
    GO:0031225anchored to membrane IEA--
    GO:0045202synapse IEA--


    NRN1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NRN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NRN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026144 Neuritin_fam

    Graphical View of Domain Structure for InterPro Entry Q9NPD7

    ProtoNet protein and cluster: Q9NPD7

    UniProtKB/Swiss-Prot: NRN1_HUMAN, Q9NPD7
    Similarity: Belongs to the neuritin family


    Function
    for NRN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NRN1_HUMAN, Q9NPD7
    Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical
    cells (By similarity)

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate NRN1 (see all 42):
    hsa-miR-374a hsa-miR-449a hsa-miR-647 hsa-miR-4324 hsa-miR-34c-5p hsa-miR-449b hsa-miR-186* hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmid: NRN1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    1 GenomeRNAi human phenotype for NRN1:
     Elongated cells 

    Animal Models:
         Mouse knock-out Nrn1tm1.2Ndiv for NRN1
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nrn1):
     behavior/neurological  cellular  growth/size  nervous system  no phenotypic analysis 

    NRN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NRN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRN1

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development IEA--


    NRN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NRN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NRN1
    Search CenterWatch for drugs/clinical trials and news about NRN1 

    Transcripts
    for NRN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NRN1 gene: 
    NM_016588.2  

    Unigene Cluster for NRN1:

    Neuritin 1
    Hs.103291  [show with all ESTs]
    Unigene Representative Sequence: BC042019
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244766(uc021ykx.1 uc003mwu.3) ENST00000495850

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate NRN1 (see all 42):
    hsa-miR-374a hsa-miR-449a hsa-miR-647 hsa-miR-4324 hsa-miR-34c-5p hsa-miR-449b hsa-miR-186* hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmid: NRN1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRN1 (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRN1

    Additional cDNA sequence: 

    AF114833.1 AF136631.1 AJ420483.1 AK093824.1 AK314095.1 BC002683.2 BC042019.1 

    10 DOTS entries:

    DT.445436  DT.100792356  DT.100792349  DT.100792353  DT.121355089  DT.100029054  DT.100792345  DT.91928122 
    DT.97762304  DT.95175068 

    24/200 AceView cDNA sequences (see all 200):

    BQ720570 AI919239 CD107153 NM_016588 BQ679962 CD519184 BC002683 CR620311 
    BU150419 AF136631 CR624108 BU177968 BM974374 CR614740 BQ774533 BU190549 
    BU185614 W17083 BM704247 BQ005144 BX279990 AA054618 BE296947 CR610397 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NRN1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:        -           -     -     -     -                           
    SP2:                    -     -     -     -                           
    SP3:                          -           -                           
    SP4:                                      -                           
    SP5:                                                                  


    ECgene alternative splicing isoforms for NRN1

    Expression
    for NRN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NRN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGCTATGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NRN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NRN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NRN1

    SOURCE GeneReport for Unigene cluster: Hs.103291
        SABiosciences Custom PCR Arrays for NRN1
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    In Situ
    Assay Products:     
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    Orthologs
    for NRN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NRN1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nrn11 , 5 neuritin 11, 5 96.71(n)1
    97.18(a)1    		   13 (14.44 cM)5
    684041  NM_153529.11  NP_705757.11 
     367256255 
    chicken
    (Gallus gallus)    		 Aves NRN11 neuritin 1 81.29(n)
    80.58(a)    		   420873  NM_001198731.1  NP_001185660.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NRN16
    		 --
    		 70(a)
    		 1 ↔ 1
    		 GL343421.1(567183-604296)
    African clawed frog
    (Xenopus laevis)    		 Amphibia nrn1-A2 neuritin 1/candidate plasticity gene 15 80.25(n)    AF378092.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.292312 Transcribed sequence with weak similarity to protein more 73.96(n)    CK360748.1 


    ENSEMBL Gene Tree for NRN1 (if available)
    TreeFam Gene Tree for NRN1 (if available) 

    Paralogs
    for NRN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NRN1 gene
    NRN1L2  
    1 SIMAP similar gene for NRN1 using alignment to 1 protein entry:     NRN1_HUMAN:
    NRN1L

    NRN1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NRN1
    PGOHUM00000247542


    Genomic Variants
    for NRN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/221 NCBI SNPs in NRN1 are shown (see all 221)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs121538591,2
    		C,H--5998231(+) CCCCCA/TTTTCA 1 -- ds50014Minor allele frequency- T:0.00NS EA 416
    rs2004576711,2
    		--5998334(+) TCTCT-/CTTTTT 1 -- ut310--------
    rs38343161,2
    		C,--5998335(-) AAAAA-/AGAGAG 1 -- ut310--------
    rs709759391,2
    		C--5998335(+) TTTTTT/-AAAAT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs10527271,2
    		C--5998392(-) TTAATC/TTAAAA 1 -- ut310--------
    rs1853845921,2
    		--5998510(+) GACGGA/TTGCAT 1 -- ut310--------
    rs1461480771,2
    		--5998619(+) TCTCCC/TTCCTA 1 -- ut310--------
    rs1995485331,2
    		--5998894(+) CCAAC-/AAAAAA 1 -- ut310--------
    rs2005267861,2
    		--5999239(+) GCTGCC/TGAGAG 2 S syn10--------
    rs1401634121,2
    		C,F,--5999254(+) ACCAGG/AAGCAC 2 /L syn12Minor allele frequency- A:0.01NA EU 4423

    HapMap Linkage Disequilibrium report for NRN1 (5998232 - 6007633 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NRN1
         1 CNV: 0072

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    Disorders / Diseases
    for NRN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NRN1 for disorders           About GeneDecksing

    OMIM gene information: 607409    OMIM disorders: --

    6 diseases for NRN1:    About MalaCards
    spinal cord injury    neuronitis    seizures    astrocytoma
    hypoxia    schizophrenia

    1 Novoseek disease relationship for NRN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 16723126 (1)

    Human Genome Epidemiology (HuGE) Navigator: NRN1 (1 document)

    Export disorders for NRN1 gene to outside databases

    Publications
    for NRN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NRN1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with NRN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. (PubMed id 9122250)1, 2, 3, 9 Naeve G.S....Theill L.E. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Impact of Neuritin 1 (NRN1) polymorphisms on fluid in telligence in schizophrenia. (PubMed id 19569075)1, 9 Chandler D....Jablensky A. (2010)
    6. Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. (PubMed id 16723126)1, 9 Le Jan S....Germain S. (2006)
    7. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PubMed id 18265009)1, 9 Fujino T....Nedivi E. (2008)
    8. Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits. (PubMed id 21652774)1 Akten B....Sahin M. (2011)
    9. Neuritin expression and its relation with proliferati on, apoptosis, and angiogenesis in human astrocytoma. (PubMed id 20405246)1 Zhang L....Zhen H.N. (2011)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for NRN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NRN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51299 HGNC: 17972 AceView: NRN1 Ensembl:ENSG00000124785 euGenes: HUgn51299
    ECgene: NRN1 H-InvDB: NRN1

    Other Databases showing NRN1 gene

    (According to HUGE)
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    Specialized Databases showing NRN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NRN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NRN1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NRN1 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for NRN1 gene:
    Search GeneIP for patents involving NRN1

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