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Aliases for NRN1 Gene

Aliases for NRN1 Gene

  • Neuritin 1 2 3 5
  • NRN 3 4
  • DJ380B8.2 3
  • Neuritin 3

External Ids for NRN1 Gene

Previous GeneCards Identifiers for NRN1 Gene

  • GC06M005983
  • GC06M005943
  • GC06M005873

Summaries for NRN1 Gene

Entrez Gene Summary for NRN1 Gene

  • This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for NRN1 Gene

NRN1 (Neuritin 1) is a Protein Coding gene. Diseases associated with NRN1 include Astrocytoma and Degenerative Myopia. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is NRN1L.

UniProtKB/Swiss-Prot for NRN1 Gene

  • Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.

Additional gene information for NRN1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRN1 Gene

Genomics for NRN1 Gene

GeneHancer (GH) Regulatory Elements for NRN1 Gene

Promoters and enhancers for NRN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I006005 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 558.9 +0.1 134 4 ATF1 SIN3A ZNF2 GLIS2 ZNF213 ZNF143 ATF7 KLF13 SP3 SP5 NRN1 LOC442155 PPP1R3G GC06M005970 LOC105374898 GC06P005986
GH06I006003 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 560 +3.5 3516 2 ZSCAN4 KLF17 MZF1 SIN3A GLI4 ZNF2 ZNF335 ZNF121 GLIS2 ZNF213 NRN1 GC06M005970 LOC105374898 GC06P005986
GH06I005995 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.7 +9.7 9667 4.5 PKNOX1 SIN3A GLIS2 RUNX3 KLF13 SP3 CBX8 ZNF585B GLIS1 MYNN NRN1 ENSG00000216360 LYRM4 LOC105374898 GC06M005970 GC06P005986
GH06I005979 Enhancer 0.7 FANTOM5 Ensembl ENCODE 20.7 +27.6 27556 1.1 MAX NRN1 GC06P005976 GC06P005986 GC06M005970
GH06I006545 Enhancer 1.1 Ensembl ENCODE 11.3 -539.2 -539190 2.2 HDGF PKNOX1 ATF1 RB1 BATF ZNF2 KLF5 IRF4 RAD21 RFX5 NRN1 F13A1 LY86 GC06M006539 GC06P006543 LY86-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NRN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRN1 gene promoter:

Genomic Locations for NRN1 Gene

Genomic Locations for NRN1 Gene
chr6:5,997,999-6,007,605
(GRCh38/hg38)
Size:
9,607 bases
Orientation:
Minus strand
chr6:5,998,232-6,007,633
(GRCh37/hg19)

Genomic View for NRN1 Gene

Genes around NRN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRN1 Gene

Proteins for NRN1 Gene

  • Protein details for NRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPD7-NRN1_HUMAN
    Recommended name:
    Neuritin
    Protein Accession:
    Q9NPD7
    Secondary Accessions:
    • B2RA93
    • Q7Z4Y1

    Protein attributes for NRN1 Gene

    Size:
    142 amino acids
    Molecular mass:
    15333 Da
    Quaternary structure:
    • Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for NRN1 Gene

Post-translational modifications for NRN1 Gene

No Post-translational modifications

Other Protein References for NRN1 Gene

Antibody Products

No data available for DME Specific Peptides for NRN1 Gene

Domains & Families for NRN1 Gene

Gene Families for NRN1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NRN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPD7

UniProtKB/Swiss-Prot:

NRN1_HUMAN :
  • Belongs to the neuritin family.
Family:
  • Belongs to the neuritin family.
genes like me logo Genes that share domains with NRN1: view

Function for NRN1 Gene

Molecular function for NRN1 Gene

UniProtKB/Swiss-Prot Function:
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.

Phenotypes From GWAS Catalog for NRN1 Gene

Gene Ontology (GO) - Molecular Function for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with NRN1: view
genes like me logo Genes that share phenotypes with NRN1: view

Animal Models for NRN1 Gene

MGI Knock Outs for NRN1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRN1 Gene

Localization for NRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRN1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with NRN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NRN1 Gene

Pathways & Interactions for NRN1 Gene

genes like me logo Genes that share pathways with NRN1: view

Interacting Proteins for NRN1 Gene

Selected Interacting proteins: Q9NPD7-NRN1_HUMAN for NRN1 Gene via IID

Symbol External ID(s) Details
NGF
TRIM21

Gene Ontology (GO) - Biological Process for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0007399 nervous system development IEA --
GO:1990138 neuron projection extension IEA --
genes like me logo Genes that share ontologies with NRN1: view

No data available for SIGNOR curated interactions for NRN1 Gene

Drugs & Compounds for NRN1 Gene

No Compound Related Data Available

Transcripts for NRN1 Gene

Unigene Clusters for NRN1 Gene

Neuritin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for NRN1 Gene

GeneLoc Exon Structure for
NRN1
ECgene alternative splicing isoforms for
NRN1

Expression for NRN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRN1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.5), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for NRN1 Gene

This gene is overexpressed in Cerebrospinal fluid (39.7) and Frontal cortex (22.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NRN1 Gene



Protein tissue co-expression partners for NRN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRN1 Gene:

NRN1

SOURCE GeneReport for Unigene cluster for NRN1 Gene:

Hs.103291

Evidence on tissue expression from TISSUES for NRN1 Gene

  • Nervous system(4.9)
  • Adrenal gland(4.1)
genes like me logo Genes that share expression patterns with NRN1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRN1 Gene

Orthologs for NRN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRN1 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia NRN1 33 34
  • 98.12 (n)
cow
(Bos Taurus)
Mammalia NRN1 33 34
  • 97.18 (n)
mouse
(Mus musculus)
Mammalia Nrn1 33 16 34
  • 96.71 (n)
rat
(Rattus norvegicus)
Mammalia Nrn1 33
  • 96.71 (n)
oppossum
(Monodelphis domestica)
Mammalia NRN1 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves NRN1 33 34
  • 81.29 (n)
lizard
(Anolis carolinensis)
Reptilia NRN1 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrn1 33
  • 76.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia nrn1-A 33
zebrafish
(Danio rerio)
Actinopterygii nrn1a 33 34
  • 66.9 (n)
nrn1b 34
  • 50 (a)
OneToMany
Dr.29231 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11184 33
Species where no ortholog for NRN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRN1 Gene

ENSEMBL:
Gene Tree for NRN1 (if available)
TreeFam:
Gene Tree for NRN1 (if available)

Paralogs for NRN1 Gene

Paralogs for NRN1 Gene

(1) SIMAP similar genes for NRN1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NRN1 Gene

genes like me logo Genes that share paralogs with NRN1: view

Variants for NRN1 Gene

Sequence variations from dbSNP and Humsavar for NRN1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000007703 -- 5,998,955(-) C/A 3_prime_UTR_variant
rs1000040337 -- 5,998,587(-) C/T 3_prime_UTR_variant
rs1000063669 -- 6,001,410(-) AG/ intron_variant
rs1000124269 -- 6,005,363(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000457735 -- 6,004,229(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NRN1 Gene

Variant ID Type Subtype PubMed ID
esv3607988 CNV gain 21293372
nsv436891 CNV insertion 17901297

Variation tolerance for NRN1 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRN1 Gene

Human Gene Mutation Database (HGMD)
NRN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRN1 Gene

Disorders for NRN1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NRN1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
astrocytoma
  • astrocytic tumor
degenerative myopia
  • degenerative progressive high myopia
persistent hyperplastic primary vitreous
  • congenital retinal detachment
- elite association - COSMIC cancer census association via MalaCards
Search NRN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRN1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NRN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRN1 Gene

Publications for NRN1 Gene

  1. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. (PMID: 9122250) Naeve GS … Theill LE (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  2. Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia. (PMID: 19569075) Chandler D … Jablensky A (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 22 44 58
  3. cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PMID: 18265009) Fujino T … Nedivi E (The Journal of comparative neurology 2008) 3 22 58
  4. Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. (PMID: 16723126) Le Jan S … Germain S (FEBS letters 2006) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for NRN1 Gene

Sources for NRN1 Gene

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