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Aliases for NRN1 Gene

Aliases for NRN1 Gene

  • Neuritin 1 2 3
  • NRN 3 4 6
  • DJ380B8.2 3
  • Neuritin 3

External Ids for NRN1 Gene

Summaries for NRN1 Gene

Entrez Gene Summary for NRN1 Gene

  • This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for NRN1 Gene

NRN1 (Neuritin 1) is a Protein Coding gene. Diseases associated with NRN1 include astrocytoma. An important paralog of this gene is NRN1L.

UniProtKB/Swiss-Prot for NRN1 Gene

  • Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRN1 Gene

Genomics for NRN1 Gene

Genomic Location for NRN1 Gene

Start:
5,997,999 bp from pter
End:
6,007,605 bp from pter
Size:
9,607 bases
Orientation:
Minus strand

Genomic View for NRN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRN1 Gene

Regulatory Elements for NRN1 Gene

Proteins for NRN1 Gene

  • Protein details for NRN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPD7-NRN1_HUMAN
    Recommended name:
    Neuritin
    Protein Accession:
    Q9NPD7
    Secondary Accessions:
    • B2RA93
    • Q7Z4Y1

    Protein attributes for NRN1 Gene

    Size:
    142 amino acids
    Molecular mass:
    15333 Da
    Quaternary structure:
    • Component of the outer core of AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

neXtProt entry for NRN1 Gene

Proteomics data for NRN1 Gene at MOPED

Post-translational modifications for NRN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRN1 Gene

No data available for DME Specific Peptides for NRN1 Gene

Domains for NRN1 Gene

Protein Domains for NRN1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NRN1_HUMAN
Family:
  • Belongs to the neuritin family.:
    • Q9NPD7
genes like me logo Genes that share domains with NRN1: view

No data available for Gene Families for NRN1 Gene

Function for NRN1 Gene

Molecular function for NRN1 Gene

UniProtKB/Swiss-Prot Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
genes like me logo Genes that share phenotypes with NRN1: view

Animal Models for NRN1 Gene

MGI Knock Outs for NRN1:

miRNA for NRN1 Gene

miRTarBase miRNAs that target NRN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for NRN1 Gene

Localization for NRN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRN1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRN1 Gene COMPARTMENTS Subcellular localization image for NRN1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0030054 cell junction IEA --
GO:0031225 anchored component of membrane IEA --
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with NRN1: view

Pathways for NRN1 Gene

SuperPathways for NRN1 Gene

No Data Available

Interacting Proteins for NRN1 Gene

Gene Ontology (GO) - Biological Process for NRN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with NRN1: view

No data available for Pathways by source for NRN1 Gene

Transcripts for NRN1 Gene

Unigene Clusters for NRN1 Gene

Neuritin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for NRN1 Gene

GeneLoc Exon Structure for
NRN1
ECgene alternative splicing isoforms for
NRN1

Expression for NRN1 Gene

mRNA expression in normal human tissues for NRN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRN1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.9), Brain - Cortex (5.5), Brain - Anterior cingulate cortex (BA24) (4.8), and Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NRN1 Gene

SOURCE GeneReport for Unigene cluster for NRN1 Gene Hs.103291

genes like me logo Genes that share expressions with NRN1: view

Orthologs for NRN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRN1 36
  • 100 (n)
  • 100 (a)
NRN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRN1 36
  • 97.18 (n)
  • 97.89 (a)
NRN1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRN1 36
  • 98.12 (n)
  • 98.59 (a)
NRN1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrn1 36
  • 96.71 (n)
  • 97.18 (a)
Nrn1 16
Nrn1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRN1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 56 (a)
OneToMany
-- 37
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nrn1 36
  • 96.71 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves NRN1 36
  • 81.29 (n)
  • 80.58 (a)
NRN1 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRN1 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nrn1-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nrn1 36
  • 76.72 (n)
  • 72.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11184 36
zebrafish
(Danio rerio)
Actinopterygii Dr.29231 36
nrn1a 36
  • 66.9 (n)
  • 68.31 (a)
nrn1a 37
  • 70 (a)
OneToMany
nrn1b 37
  • 50 (a)
OneToMany
Species with no ortholog for NRN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRN1 Gene

ENSEMBL:
Gene Tree for NRN1 (if available)
TreeFam:
Gene Tree for NRN1 (if available)

Paralogs for NRN1 Gene

Paralogs for NRN1 Gene

Selected SIMAP similar genes for NRN1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NRN1 Gene

genes like me logo Genes that share paralogs with NRN1: view

Variants for NRN1 Gene

Sequence variations from dbSNP and Humsavar for NRN1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs107738 -- 6,001,895(-) TGTTT(A/G)GGGTA intron-variant
rs582186 -- 6,001,148(+) GGGGC(A/G)TTTAG intron-variant
rs582677 -- 6,007,829(+) GGGCA(C/T)CGGGG upstream-variant-2KB
rs609764 -- 6,009,312(+) GTTCT(C/T)GCCCT upstream-variant-2KB
rs642151 -- 6,003,953(+) CGGGA(A/G)GACCG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NRN1 Gene

Variant ID Type Subtype PubMed ID
nsv436891 CNV Insertion 17901297
nsv483131 CNV Loss 15286789

Relevant External Links for NRN1 Gene

HapMap Linkage Disequilibrium report
NRN1
Human Gene Mutation Database (HGMD)
NRN1

Disorders for NRN1 Gene

(1) MalaCards Diseases for NRN1 Gene

Search for NRN1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for NRN1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for NRN1

Genetic Association Database (GAD)
NRN1
Human Genome Epidemiology (HuGE) Navigator
NRN1
genes like me logo Genes that share disorders with NRN1: view

No data available for UniProtKB/Swiss-Prot for NRN1 Gene

Publications for NRN1 Gene

  1. Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. (PMID: 9122250) Naeve G.S. … Theill L.E. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia. (PMID: 19569075) Chandler D. … Jablensky A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23 49
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NRN1 Gene

Sources for NRN1 Gene

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