NRM Gene
protein-coding GIFtS: 44
GCID: GC06M030655
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|
nurim (nuclear envelope membrane protein)
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Aliases
for NRM gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nurim (Nuclear Envelope Membrane Protein)1 2 | | NRM291 2 3 | | Nuclear Rim Protein2 3 | | Nurim1 | | Nuclear Envelope Membrane Protein3 |
Export aliases for NRM gene to outside databasesPrevious GC identifers: GC06M030711 GC06M030426 GC06M030761 GC06M030763 |
Summaries
for NRM gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NRM:
The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where itis tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferaseenzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms.(provided by RefSeq, Jul 2012)
|
Genomic Views
for NRM gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NRM gene promoter:
GR AP-1 ATF-2 GR-beta STAT3 GR-alpha c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NRM
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRM |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.33 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3NRM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M030655: view genomic region
(about GC identifiers)
Start:
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30,655,824 bp from pter |
End:
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30,659,197 bp from pter |
Size:
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3,374 bases |
Orientation:
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minus strand |
6 alternative locations:
| Chr6-,ALT_REF_LOCI_3 30,646,089-30,660,072 | Chr6-,ALT_REF_LOCI_2 30,645,693-30,687,826 | Chr6-,ALT_REF_LOCI_5 30,649,134-30,652,077 | | Chr6-,ALT_REF_LOCI_4 30,623,581-30,626,524 | Chr6-,ALT_REF_LOCI_1 30,664,073-30,675,318 | Chr6-,ALT_REF_LOCI_6 30,645,360-30,683,886 | |
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Proteins
for NRM gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NRM_HUMAN, Q8IXM6 (See
protein sequence)Recommended Name: Nurim Size: 262 amino acids; 29379 Da
Subcellular location: Nucleus inner membrane; Multi-pass membrane protein
Secondary accessions: B0S7R0 B0S7R1 Q5JP57 Q5JP58 Q5JP59 Q5JP60 Q8WU45 Q9BSX3 Q9UN92Alternative splicing: 2 isoforms: Q8IXM6-1 Q8IXM6-2 Explore the universe of human proteins at neXtProt for NRM: NX_Q8IXM6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IXM6
NRM Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001257636.1 NP_001257637.1 NP_001257638.1 NP_001257639.1 NP_009174.1
ENSEMBL proteins: ENSP00000259953 ENSP00000365602 ENSP00000397892 ENSP00000365603
Human Recombinant Protein Products for NRM:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NRM for ontologies About GeneDecksing
NRM Antibody Products:
Assay Products for NRM: |
Protein
Domains /
Families
for NRM gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NRM for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IXM6ProtoNet protein and cluster: Q8IXM6 UniProtKB/Swiss-Prot: NRM_HUMAN, Q8IXM6Similarity: Belongs to the nurim family |
Function
for NRM gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
NRM for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for NRM:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRM (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRM
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NRM (NM_007243) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRM | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRM |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRM |
|
Pathways & Interactions
for NRM gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRM
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
NRM for ontologies About GeneDecksing
|
Drugs & Compounds
for NRM gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NRM
Search CenterWatch for drugs/clinical trials and news about NRM
|
Transcripts
for NRM gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NRM gene (5 alternative transcripts): NM_001270707.1 NM_001270708.1 NM_001270709.1 NM_001270710.1 NM_007243.2 Unigene Cluster for NRM: Nurim (nuclear envelope membrane protein) Hs.519993 [show with all ESTs]Unigene Representative Sequence: NM_0072439 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000259953(uc003nrc.3 uc003nre.3) ENST00000470733 ENST00000482141
ENST00000462857 ENST00000376420 ENST00000474864 ENST00000444096 ENST00000495946
ENST00000376421
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRM (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRM
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NRM (NM_007243) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRM | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRM |
Additional cDNA sequence: AF143676.1 AK075509.1 AK298152.1 AK315190.1 AY358411.1 BC004509.2 BC021260.1 BC039865.1 NR_073065.1 NR_073066.1 NR_073072.1 10 DOTS entries: DT.314022 DT.97858981 DT.100815657 DT.100815653 DT.121386396 DT.121386419 DT.91767632 DT.91767636 DT.100815665 DT.97858980 24/28 AceView cDNA sequences (see all 28): BC039865 BF839747 AY358411 BC021260 CR616786 NM_007243 BC004509 CR608026 CR618359 CR609683 CR614897 CR596567 BX447254 CR623441 CR592223 AF143676 CR606826 CR597197 CR604044 CR619257 AK075509 CR604619 BX375665 AW976659
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NRM (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g |
|---|
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| SP1: | | | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NRM
|
Expression
for NRM gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NRM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACTCTCCC
About this image
See NRM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NRM
SOURCE GeneReport for Unigene cluster: Hs.519993
SABiosciences Custom PCR Arrays for NRM
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRM
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NRM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRM | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRM |
Orthologs
for NRM gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NRM gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for NRM (if available)
TreeFam Gene Tree for NRM (if available) |
Paralogs
for NRM gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NRM gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NRM (30655824 - 30659197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NRM
1 CNV: 3600 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRM |
|
Disorders
/ Diseases
for NRM gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NRM for disorders About GeneDecksing
5  diseases for NRM: About MalaCardssystemic lupus erythematosus lupus erythematosus lipodystrophy tuberculosis
mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: NRM (8 documents)
Export disorders for NRM gene to outside databases
|
Publications
for NRM gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NRM gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with NRM) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. (PubMed id 10402458)1, 2, 3 Rolls M.M.... Rapoport T.A. (1999)
- Early sorting of inner nuclear membrane proteins is c onserved. (PubMed id 17517639)1, 3 Braunagel S.C....Summers M.D. (2007)
- Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane. (PubMed id 15542857)1, 2 Hofemeister H. and O'Hare P. (2005)
- The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. (PubMed id 23092226)1 Chen H.... Zhou R. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PubMed id 16702430)2 Shiina T.... Bahram S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for NRM gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NRM gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NRM gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NRM gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NRM | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NRM gene:
Search GeneIP for patents involving NRM
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NRM gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NRM | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRM | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRM | | | OriGene Protein Over-expression Lysate for NRM | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NRM | | OriGene 3'-UTR Clone for NRM | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRM | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRM | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NRM | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NRM | | OriGene Custom Protein Services for NRM | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NRM | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRM | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRM | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRM |
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| | | | Search Tocris compounds for NRM |
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 | | | NRM Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRM |
|  |  |  |  | | | | ThermoFisher Antibodies for NRM |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRM |
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