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Aliases for NRM Gene

Aliases for NRM Gene

  • Nurim 2 3 3
  • Nurim (Nuclear Envelope Membrane Protein) 2 3 5
  • Nuclear Rim Protein 3 4
  • NRM29 3 4
  • Nuclear Envelope Membrane Protein 4

External Ids for NRM Gene

Previous GeneCards Identifiers for NRM Gene

  • GC06M030711
  • GC06M030426
  • GC06M030761
  • GC06M030763

Summaries for NRM Gene

Entrez Gene Summary for NRM Gene

  • The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for NRM Gene

NRM (Nurim) is a Protein Coding gene.

Additional gene information for NRM Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRM Gene

Genomics for NRM Gene

Regulatory Elements for NRM Gene

Enhancers for NRM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H030611 1.7 Ensembl ENCODE dbSUPER 55.9 +75.9 75868 8.7 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 MDC1 DDX39B TRIM39 PPP1R10 ABCF1 NRM DHX16 ZNRD1 GTF2H4 TRIM26
GH06H031538 1.4 ENCODE dbSUPER 61.7 -849.7 -849719 4.9 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 MCM3 PPARGC1A MEF2D ATF6B LSM2 LY6G5B DDX39B MDC1 PPP1R10 NRM DHX16 MSH5 TCF19
GH06H030715 1.5 ENCODE dbSUPER 43.4 -28.1 -28107 7.7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC MDC1 LY6G5B TRIM39 DDX39B DHX16 ABCF1 PPP1R10 ZNRD1 NRM HCG18
GH06H030554 1.4 ENCODE dbSUPER 35.7 +134.8 134796 3.6 DMAP1 YY1 SLC30A9 ZNF143 SP3 SSRP1 GLIS1 NBN NR2C1 KDM1A DDX39B TRIM39 DHX16 PPP1R10 NRM ZNRD1 MDC1 TCF19 ETF1P1 ENSG00000233892
GH06H030678 1.9 FANTOM5 ENCODE dbSUPER 24.7 +6.1 6095 13.5 MLX DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC MEF2D PPP1R10 MDC1 IER3 NRM TRIM39 RPL7P4 DHX16 ABCF1 HLA-E PPP1R18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRM on UCSC Golden Path with GeneCards custom track

Promoters for NRM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195425 520 1001 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Locations for NRM Gene

Genomic Locations for NRM Gene
chr6:30,688,047-30,691,420
(GRCh38/hg38)
Size:
3,374 bases
Orientation:
Minus strand
chr6:30,655,824-30,659,197
(GRCh37/hg19)

Genomic View for NRM Gene

Genes around NRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NRM Gene

  • Protein details for NRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXM6-NRM_HUMAN
    Recommended name:
    Nurim
    Protein Accession:
    Q8IXM6
    Secondary Accessions:
    • B0S7R0
    • B0S7R1
    • I3XIE2
    • I3XIE3
    • Q5JP57
    • Q5JP58
    • Q5JP59
    • Q5JP60
    • Q8WU45
    • Q9BSX3
    • Q9UN92

    Protein attributes for NRM Gene

    Size:
    262 amino acids
    Molecular mass:
    29379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRM Gene

Post-translational modifications for NRM Gene

  • Ubiquitination at posLast=121121, Lys184, and Lys249
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRM Gene

Domains & Families for NRM Gene

Gene Families for NRM Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NRM Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IXM6

UniProtKB/Swiss-Prot:

NRM_HUMAN :
  • Belongs to the nurim family.
Family:
  • Belongs to the nurim family.
genes like me logo Genes that share domains with NRM: view

Function for NRM Gene

Phenotypes From GWAS Catalog for NRM Gene

Gene Ontology (GO) - Molecular Function for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRM: view
genes like me logo Genes that share phenotypes with NRM: view

Animal Model Products

CRISPR Products

miRNA for NRM Gene

miRTarBase miRNAs that target NRM

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRM Gene

Localization for NRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRM Gene

Nucleus inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRM gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA 10402458
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NRM: view

Pathways & Interactions for NRM Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRM: view

No data available for Pathways by source and SIGNOR curated interactions for NRM Gene

Drugs & Compounds for NRM Gene

No Compound Related Data Available

Transcripts for NRM Gene

Unigene Clusters for NRM Gene

Nurim (nuclear envelope membrane protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRM Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - -
SP8:
SP9: - - -

Relevant External Links for NRM Gene

GeneLoc Exon Structure for
NRM
ECgene alternative splicing isoforms for
NRM

Expression for NRM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRM Gene

mRNA differential expression in normal tissues according to GTEx for NRM Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for NRM Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRM Gene



Protein tissue co-expression partners for NRM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRM Gene:

NRM

SOURCE GeneReport for Unigene cluster for NRM Gene:

Hs.519993

Evidence on tissue expression from TISSUES for NRM Gene

  • Blood(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NRM: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRM Gene

Orthologs for NRM Gene

This gene was present in the common ancestor of animals.

Orthologs for NRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRM 33 34
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia NRM 33 34
  • 92.1 (n)
cow
(Bos Taurus)
Mammalia NRM 33 34
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Nrm 33 16 34
  • 87.68 (n)
rat
(Rattus norvegicus)
Mammalia Nrm 33
  • 87.15 (n)
oppossum
(Monodelphis domestica)
Mammalia NRM 34
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRM 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489431 33
  • 58.3 (n)
zebrafish
(Danio rerio)
Actinopterygii nrm 33 34
  • 58.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7655 33 34
  • 50.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005818 33
  • 45.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for NRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRM Gene

ENSEMBL:
Gene Tree for NRM (if available)
TreeFam:
Gene Tree for NRM (if available)

Paralogs for NRM Gene

No data available for Paralogs for NRM Gene

Variants for NRM Gene

Sequence variations from dbSNP and Humsavar for NRM Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1002322612 -- 30,691,176(+) CTGTC(C/T)CTCCG upstream-variant-2KB, utr-variant-5-prime
rs1004005392 -- 30,692,238(+) CACGA(C/T)TGCTC upstream-variant-2KB
rs1004067064 -- 30,692,936(+) CAGTT(A/G)GATCA upstream-variant-2KB
rs1005031678 -- 30,688,402(+) CATGC(G/T)CTAAA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1005569430 -- 30,693,096(+) GTGGA(A/G)GTTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRM Gene

Variant ID Type Subtype PubMed ID
nsv830626 CNV loss 17160897
nsv601481 CNV loss 21841781
nsv601264 CNV loss 21841781
nsv1144137 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185
esv3411275 CNV duplication 20981092
esv3367670 CNV insertion 20981092
esv2759413 CNV loss 17122850
esv2731791 CNV deletion 23290073
esv2670269 CNV deletion 23128226

Variation tolerance for NRM Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRM Gene

Disorders for NRM Gene

Relevant External Links for NRM

Genetic Association Database (GAD)
NRM
Human Genome Epidemiology (HuGE) Navigator
NRM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRM

No disorders were found for NRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRM Gene

Publications for NRM Gene

  1. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. (PMID: 10402458) Rolls MM … Rapoport TA (The Journal of cell biology 1999) 2 3 4 60
  2. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. (PMID: 23092226) Chen H … Zhou R (Current molecular medicine 2012) 3 4 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 45 60
  5. Early sorting of inner nuclear membrane proteins is conserved. (PMID: 17517639) Braunagel SC … Summers MD (Proceedings of the National Academy of Sciences of the United States of America 2007) 2 3 60

Products for NRM Gene

Sources for NRM Gene

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