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NRM Gene

protein-coding   GIFtS: 48
GCID: GC06M030655

Nurim (Nuclear Envelope Membrane Protein)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nurim (Nuclear Envelope Membrane Protein)1 2
Nuclear Rim Protein2 3
NRM292 3
nurim2
Nuclear Envelope Membrane Protein3

External Ids:    HGNC: 80031   Entrez Gene: 112702   Ensembl: ENSG000001374047   UniProtKB: Q8IXM63   

Export aliases for NRM gene to outside databases

Previous GC identifers: GC06M030711 GC06M030426 GC06M030761 GC06M030763


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRM Gene:
The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane,
where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine
carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode
different protein isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for NRM Gene:
NRM (nurim (nuclear envelope membrane protein)) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  
NT_167248.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRM gene promoter:
         GR   AP-1   ATF-2   GR-beta   STAT3   GR-alpha   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRM promoter sequence
   Search Chromatin IP Primers for NRM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

NRM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRM gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030655:  view genomic region     (about GC identifiers)

Start:
30,655,824 bp from pter      End:
30,659,197 bp from pter
Size:
3,374 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167246 2,003,922-2,006,865      Chr6-,NT_113891.2 2,167,899-2,170,842      Chr6-,NT_167244 1,967,472-1,970,415     
Chr6-,NT_167245 1,949,488-1,952,431      Chr6-,NT_167247 2,037,711-2,040,654      Chr6-,NT_167248 1,948,759-1,951,702     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NRM_HUMAN, Q8IXM6 (See protein sequence)
Recommended Name: Nurim  
Size: 262 amino acids; 29379 Da
Secondary accessions: B0S7R0 B0S7R1 Q5JP57 Q5JP58 Q5JP59 Q5JP60 Q8WU45 Q9BSX3 Q9UN92
Alternative splicing: 2 isoforms:  Q8IXM6-1   Q8IXM6-2   

Explore the universe of human proteins at neXtProt for NRM: NX_Q8IXM6

Explore proteomics data for NRM at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys121, Lys184, Lys249
  • Modification sites at PhosphoSitePlus

  • See NRM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257636.1  NP_001257637.1  NP_001257638.1  NP_001257639.1  NP_009174.1  

    ENSEMBL proteins: 
     ENSP00000397892   ENSP00000365602   ENSP00000259953   ENSP00000365603  

    NRM Human Recombinant Protein Products:

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    Novus Biologicals NRM Protein
    Novus Biologicals NRM Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NRM

     
    Search eBioscience for Proteins for NRM 

     
    antibodies-online proteins for NRM (2 products) 

     
    antibodies-online peptides for NRM

    NRM Antibody Products:

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    ThermoFisher Antibodies for NRM
    antibodies-online antibodies for NRM (8 products) 

    NRM Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for NRM
    Cloud-Clone Corp. CLIAs for NRM
    Search eBioscience for ELISAs for NRM 
    antibodies-online kits for NRM (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009915 NnrU

    Graphical View of Domain Structure for InterPro Entry Q8IXM6

    ProtoNet protein and cluster: Q8IXM6

    UniProtKB/Swiss-Prot: NRM_HUMAN, Q8IXM6
    Similarity: Belongs to the nurim family


    Find genes that share domains with NRM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with NRM           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NRM:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NRM

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NRM (see all 11):
    hsa-miR-125a-5p hsa-miR-4299 hsa-miR-3125 hsa-miR-3916 hsa-miR-3158-3p hsa-miR-544b hsa-miR-125b hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidNRM 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NRM

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NRM (NM_007243)
    Sino Biological Human cDNA Clone for NRM
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRM

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRM_HUMAN, Q8IXM6: Nucleus inner membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA10402458
    GO:0005637nuclear inner membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NRM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRM
    Interactions:

        Search GeneGlobe Interaction Network for NRM

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NRM (ENSP000002599534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNGB1ENSP000002511024STRING: ENSP00000251102
    CNGB3ENSP000003166054STRING: ENSP00000316605
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with NRM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NRM gene (5 alternative transcripts): 
    NM_001270707.1  NM_001270708.1  NM_001270709.1  NM_001270710.1  NM_007243.2  

    Unigene Cluster for NRM:

    Nurim (nuclear envelope membrane protein)
    Hs.519993  [show with all ESTs]
    Unigene Representative Sequence: NM_007243
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495946 ENST00000444096 ENST00000482141 ENST00000474864 ENST00000376420
    ENST00000462857 ENST00000470733 ENST00000259953(uc003nrc.3 uc003nre.3)
    ENST00000376421
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NRM (see all 11):
    hsa-miR-125a-5p hsa-miR-4299 hsa-miR-3125 hsa-miR-3916 hsa-miR-3158-3p hsa-miR-544b hsa-miR-125b hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidNRM 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NRM
    Predesigned siRNA for gene silencing in human, mouse, rat NRM
    Clone
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    OriGene ORF clones in mouse, rat for NRM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NRM (NM_007243)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRM
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NRM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRM
      QuantiTect SYBR Green Assays in human, mouse, rat NRM
      QuantiFast Probe-based Assays in human, mouse, rat NRM

    Additional mRNA sequence: 

    AF143676.1 AK075509.1 AK298152.1 AK315190.1 AY358411.1 BC004509.2 BC021260.1 BC039865.1 
    NR_073065.1 NR_073066.1 NR_073072.1 

    10 DOTS entries:

    DT.314022  DT.97858981  DT.100815657  DT.100815653  DT.121386396  DT.121386419  DT.91767632  DT.91767636 
    DT.97858980  DT.100815665 

    Selected AceView cDNA sequences (see all 28):

    BC004509 AY358411 CR616786 BF839747 BC021260 BC039865 NM_007243 CR604619 
    CR606826 AF143676 CR604044 CR614897 CR608026 CR596567 CR619257 BX375665 
    BX447254 CR609683 CR592223 CR597197 AK075509 CR623441 CR618359 AW577340 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NRM (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                                            -     -           -     -                                                   
    SP2:                                            -     -                 -                                                   
    SP3:                                                  -           -     -                                                   
    SP4:                                            -     -                 -     -                                             
    SP5:                                            -     -           -     -     -                                             


    ECgene alternative splicing isoforms for NRM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTCTCCC
    NRM Expression
    About this image

    NRM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519993
        Custom PCR Arrays for NRM
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NRM gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrm1 , 5 nurim (nuclear envelope membrane protein)1, 5 87.68(n)1
    94.38(a)1
      17 (18.72 cM)5
    1065821  NM_134122.21  NP_598883.11 
     358613185 
    lizard
    (Anolis carolinensis)
    Reptilia NRM6
    nurim (nuclear envelope membrane protein)
    59(a)
    1 ↔ 1
    2(191899771-191910091)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480584092   -- 73.29(n)    48058409 
    zebrafish
    (Danio rerio)
    Actinopterygii nrm1 nurim (nuclear envelope membrane protein 58.2(n)
    52.42(a)
      570027  NM_001045195.1  NP_001038660.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76551 CG7655 50.18(n)
    37.36(a)
      42128  NM_142389.3  NP_650646.1 


    ENSEMBL Gene Tree for NRM (if available)
    TreeFam Gene Tree for NRM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRM (see all 52)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406488601,2
    C--30657734(+) TTTGCC/GCCTCC 8 -- int10--------
    rs1156464021,2
    C--30658076(+) TGTTTC/TCCCCA 8 -- int11Minor allele frequency- T:0.01NA 120
    rs10754961,2
    C,F,A,H--30658239(-) ATGTGG/TTGTTC 8 -- int141Minor allele frequency- T:0.45MN NS EA NA WA CSA 4031
    rs1411506621,2
    --30658382(+) ACTCCC/GGTCAC 8 -- int1 nc-transcript-variant0--------
    rs22697031,2
    C,F,H--30658385(-) GCGGTG/AACCGG 8 -- int1 nc-transcript-variant21Minor allele frequency- A:0.06EA MN NS NA WA EU 4641
    rs1156655261,2
    C,F--30658445(+) TCCTTG/CAGTTC 8 -- int1 nc-transcript-variant1Minor allele frequency- C:0.02WA 118
    rs1140894711,2
    C,F--30658508(+) GTTCGA/TGTTCC 8 -- int1 nc-transcript-variant3Minor allele frequency- T:0.02WA NA EU 827
    rs1512608471,2
    C,F--30658739(+) GAGCAG/ATGCAG 13 /L nc-transcript-variantus2k1 syn11Minor allele frequency- A:0.00NA 4112
    rs1180465231,2
    C,F--30658905(+) CTTCCC/ACATCC 8 -- nc-transcript-variantus2k1 ut511Minor allele frequency- A:0.05EA 120
    rs1854098981,2
    --30658978(+) GTTAGA/CATCCC 8 -- us2k1 ut510--------

    HapMap Linkage Disequilibrium report for NRM (30655824 - 30659197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NRM:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670269CNV Deletion23128226
    esv2731791CNV Deletion23290073
    dgv6528n71CNV Loss21882294
    nsv884094CNV Loss21882294
    dgv6527n71CNV Loss21882294
    nsv830626CNV Loss17160897
    nsv884086CNV Gain21882294
    dgv1917e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with NRM           About GenesLikeMe

    Genetic Association Database (GAD): NRM
    Human Genome Epidemiology (HuGE) Navigator: NRM (8 documents)

    Export disorders for NRM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRM gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with NRM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. (PubMed id 10402458)1, 2, 3 Rolls M.M.... Rapoport T.A. (J. Cell Biol. 1999)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    4. Early sorting of inner nuclear membrane proteins is conserved. (PubMed id 17517639)1, 3 Braunagel S.C....Summers M.D. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    5. Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane. (PubMed id 15542857)1, 2 Hofemeister H. and O'Hare P. (J. Biol. Chem. 2005)
    6. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. (PubMed id 23092226)1 Chen H.... Zhou R. (Curr. Mol. Med. 2012)
    7. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1. (PubMed id 19950296)4 Okada Y....Yamamoto K. (Arthritis Rheum. 2009)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11270 HGNC: 8003 AceView: NRM Ensembl:ENSG00000137404 euGenes: HUgn11270
    ECgene: NRM H-InvDB: NRM

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRM gene:
    Search GeneIP for patents involving NRM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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