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Aliases for NRM Gene

Aliases for NRM Gene

  • Nurim (Nuclear Envelope Membrane Protein) 2 3
  • Nuclear Rim Protein 3 4
  • NRM29 3 4
  • Nuclear Envelope Membrane Protein 4
  • Nurim 3

External Ids for NRM Gene

Previous GeneCards Identifiers for NRM Gene

  • GC06M030711
  • GC06M030426
  • GC06M030761
  • GC06M030763

Summaries for NRM Gene

Entrez Gene Summary for NRM Gene

  • The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for NRM Gene

NRM (Nurim (Nuclear Envelope Membrane Protein)) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRM Gene

Genomics for NRM Gene

Regulatory Elements for NRM Gene

Genomic Location for NRM Gene

30,688,047 bp from pter
30,691,420 bp from pter
3,374 bases
Minus strand

Genomic View for NRM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NRM Gene

  • Protein details for NRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B0S7R0
    • B0S7R1
    • I3XIE2
    • I3XIE3
    • Q5JP57
    • Q5JP58
    • Q5JP59
    • Q5JP60
    • Q8WU45
    • Q9BSX3
    • Q9UN92

    Protein attributes for NRM Gene

    262 amino acids
    Molecular mass:
    29379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRM Gene


neXtProt entry for NRM Gene

Proteomics data for NRM Gene at MOPED

Post-translational modifications for NRM Gene

  • Ubiquitination at Lys121, Lys184, and Lys249
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NRM Gene

Domains for NRM Gene

Protein Domains for NRM Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nurim family.
  • Belongs to the nurim family.
genes like me logo Genes that share domains with NRM: view

No data available for Gene Families for NRM Gene

Function for NRM Gene

Gene Ontology (GO) - Molecular Function for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRM: view

Phenotypes for NRM Gene

GenomeRNAi human phenotypes for NRM:
genes like me logo Genes that share phenotypes with NRM: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NRM Gene

Localization for NRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRM Gene

Nucleus inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NRM Gene COMPARTMENTS Subcellular localization image for NRM gene
Compartment Confidence
nucleus 5
plasma membrane 3
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005635 nuclear envelope IDA 10402458
GO:0005637 nuclear inner membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NRM: view

Pathways for NRM Gene

SuperPathways for NRM Gene

No Data Available

Interacting Proteins for NRM Gene

Selected Interacting proteins: Q8IXM6-NRM_HUMAN for NRM Gene via UniProtKB

Gene Ontology (GO) - Biological Process for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRM: view

No data available for Pathways by source for NRM Gene

Transcripts for NRM Gene

Unigene Clusters for NRM Gene

Nurim (nuclear envelope membrane protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRM Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - -
SP9: - - -

Relevant External Links for NRM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRM Gene

mRNA expression in normal human tissues for NRM Gene

mRNA differential expression in normal tissues according to GTEx for NRM Gene

This gene is overexpressed in Whole Blood (5.0).

Protein differential expression in normal tissues for NRM Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NRM Gene

SOURCE GeneReport for Unigene cluster for NRM Gene Hs.519993

genes like me logo Genes that share expressions with NRM: view

Expression partners for NRM Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NRM Gene

Orthologs for NRM Gene

This gene was present in the common ancestor of animals.

Orthologs for NRM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NRM 35
  • 91.3 (n)
  • 93.57 (a)
NRM 36
  • 92 (a)
(Canis familiaris)
Mammalia NRM 35
  • 92.1 (n)
  • 95.18 (a)
NRM 36
  • 89 (a)
(Mus musculus)
Mammalia Nrm 35
  • 87.68 (n)
  • 94.38 (a)
Nrm 16
Nrm 36
  • 94 (a)
(Pan troglodytes)
Mammalia NRM 35
  • 99.75 (n)
  • 99.62 (a)
NRM 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nrm 35
  • 87.15 (n)
  • 93.57 (a)
(Monodelphis domestica)
Mammalia NRM 36
  • 63 (a)
(Anolis carolinensis)
Reptilia NRM 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489431 35
  • 58.3 (n)
  • 55.56 (a)
(Danio rerio)
Actinopterygii nrm 35
  • 58.2 (n)
  • 52.42 (a)
nrm 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005818 35
  • 45.75 (n)
  • 35.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7655 35
  • 50.18 (n)
  • 37.36 (a)
CG7655 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for NRM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRM Gene

Gene Tree for NRM (if available)
Gene Tree for NRM (if available)

Paralogs for NRM Gene

No data available for Paralogs for NRM Gene

Variants for NRM Gene

Sequence variations from dbSNP and Humsavar for NRM Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1075496 -- 30,690,462(-) ATGTG(G/T)TGTTC intron-variant
rs2269703 -- 30,690,608(-) GCGGT(A/G)ACCGG intron-variant, nc-transcript-variant
rs3130644 -- 30,692,888(+) tgggc(A/G)cagtg upstream-variant-2KB
rs6457256 -- 30,693,230(+) ctagg(C/T)gggtg upstream-variant-2KB
rs9357100 -- 30,692,033(+) aatta(C/G)ccggg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRM Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
nsv884094 CNV Loss 21882294
dgv1917e1 CNV Complex 17122850
dgv6527n71 CNV Loss 21882294
dgv6528n71 CNV Loss 21882294

Relevant External Links for NRM Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRM Gene

Disorders for NRM Gene

Relevant External Links for NRM

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NRM Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NRM Gene

Publications for NRM Gene

  1. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. (PMID: 10402458) Rolls M.M. … Rapoport T.A. (J. Cell Biol. 1999) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane. (PMID: 15542857) Hofemeister H. … O'Hare P. (J. Biol. Chem. 2005) 3 4
  4. Early sorting of inner nuclear membrane proteins is conserved. (PMID: 17517639) Braunagel S.C. … Summers M.D. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for NRM Gene

Sources for NRM Gene

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