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Aliases for NRM Gene

Aliases for NRM Gene

  • Nurim (Nuclear Envelope Membrane Protein) 2 3
  • Nuclear Rim Protein 3 4
  • NRM29 3 4
  • Nuclear Envelope Membrane Protein 4

External Ids for NRM Gene

Previous GeneCards Identifiers for NRM Gene

  • GC06M030711
  • GC06M030426
  • GC06M030761
  • GC06M030763

Summaries for NRM Gene

Entrez Gene Summary for NRM Gene

  • The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for NRM Gene

NRM (Nurim (Nuclear Envelope Membrane Protein)) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRM Gene

Genomics for NRM Gene

Regulatory Elements for NRM Gene

Genomic Location for NRM Gene

Chromosome:
6
Start:
30,688,047 bp from pter
End:
30,691,420 bp from pter
Size:
3,374 bases
Orientation:
Minus strand

Genomic View for NRM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NRM Gene

  • Protein details for NRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXM6-NRM_HUMAN
    Recommended name:
    Nurim
    Protein Accession:
    Q8IXM6
    Secondary Accessions:
    • B0S7R0
    • B0S7R1
    • I3XIE2
    • I3XIE3
    • Q5JP57
    • Q5JP58
    • Q5JP59
    • Q5JP60
    • Q8WU45
    • Q9BSX3
    • Q9UN92

    Protein attributes for NRM Gene

    Size:
    262 amino acids
    Molecular mass:
    29379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRM Gene

Proteomics data for NRM Gene at MOPED

Post-translational modifications for NRM Gene

  • Ubiquitination at Lys 121, Lys 184, and Lys 249
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NRM Gene

Domains & Families for NRM Gene

Protein Domains for NRM Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IXM6

UniProtKB/Swiss-Prot:

NRM_HUMAN :
  • Belongs to the nurim family.
Family:
  • Belongs to the nurim family.
genes like me logo Genes that share domains with NRM: view

No data available for Gene Families for NRM Gene

Function for NRM Gene

Gene Ontology (GO) - Molecular Function for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRM: view

Phenotypes for NRM Gene

genes like me logo Genes that share phenotypes with NRM: view

miRNA for NRM Gene

miRTarBase miRNAs that target NRM

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NRM Gene

Localization for NRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRM Gene

Nucleus inner membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005635 nuclear envelope IDA 10402458
GO:0005637 nuclear inner membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NRM: view

No data available for Subcellular locations from COMPARTMENTS for NRM Gene

Pathways & Interactions for NRM Gene

SuperPathways for NRM Gene

No Data Available

Interacting Proteins for NRM Gene

Selected Interacting proteins: Q8IXM6-NRM_HUMAN for NRM Gene via UniProtKB

Gene Ontology (GO) - Biological Process for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRM: view

No data available for Pathways by source and SIGNOR curated interactions for NRM Gene

Drugs & Compounds for NRM Gene

No Compound Related Data Available

Transcripts for NRM Gene

Unigene Clusters for NRM Gene

Nurim (nuclear envelope membrane protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRM Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - -
SP8:
SP9: - - -

Relevant External Links for NRM Gene

GeneLoc Exon Structure for
NRM
ECgene alternative splicing isoforms for
NRM

Expression for NRM Gene

mRNA expression in normal human tissues for NRM Gene

mRNA differential expression in normal tissues according to GTEx for NRM Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for NRM Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NRM Gene



SOURCE GeneReport for Unigene cluster for NRM Gene Hs.519993

genes like me logo Genes that share expression patterns with NRM: view

Protein tissue co-expression partners for NRM Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NRM Gene

Orthologs for NRM Gene

This gene was present in the common ancestor of animals.

Orthologs for NRM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRM 35
  • 91.3 (n)
  • 93.57 (a)
NRM 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRM 35
  • 92.1 (n)
  • 95.18 (a)
NRM 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrm 35
  • 87.68 (n)
  • 94.38 (a)
Nrm 16
Nrm 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRM 35
  • 99.75 (n)
  • 99.62 (a)
NRM 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrm 35
  • 87.15 (n)
  • 93.57 (a)
oppossum
(Monodelphis domestica)
Mammalia NRM 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRM 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489431 35
  • 58.3 (n)
  • 55.56 (a)
zebrafish
(Danio rerio)
Actinopterygii nrm 35
  • 58.2 (n)
  • 52.42 (a)
nrm 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005818 35
  • 45.75 (n)
  • 35.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7655 35
  • 50.18 (n)
  • 37.36 (a)
CG7655 36
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for NRM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRM Gene

ENSEMBL:
Gene Tree for NRM (if available)
TreeFam:
Gene Tree for NRM (if available)

Paralogs for NRM Gene

No data available for Paralogs for NRM Gene

Variants for NRM Gene

Structural Variations from Database of Genomic Variants (DGV) for NRM Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
nsv884094 CNV Loss 21882294
dgv1917e1 CNV Complex 17122850
dgv6527n71 CNV Loss 21882294
dgv6528n71 CNV Loss 21882294

Variation tolerance for NRM Gene

Residual Variation Intolerance Score: 58.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRM Gene

HapMap Linkage Disequilibrium report
NRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NRM Gene

Disorders for NRM Gene

Relevant External Links for NRM

Genetic Association Database (GAD)
NRM
Human Genome Epidemiology (HuGE) Navigator
NRM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRM
genes like me logo Genes that share disorders with NRM: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRM Gene

Publications for NRM Gene

  1. Early sorting of inner nuclear membrane proteins is conserved. (PMID: 17517639) Braunagel S.C. … Summers M.D. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 67
  2. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. (PMID: 10402458) Rolls M.M. … Rapoport T.A. (J. Cell Biol. 1999) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. (PMID: 23092226) Chen H. … Zhou R. (Curr. Mol. Med. 2012) 67
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 67

Products for NRM Gene

Sources for NRM Gene

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