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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NRM Gene

protein-coding   GIFtS: 46
GCID: GC06M030655

Nurim (Nuclear Envelope Membrane Protein)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nurim (Nuclear Envelope Membrane Protein)1 2
Nuclear Rim Protein2 3
NRM292 3
nurim2
Nuclear Envelope Membrane Protein3

External Ids:    HGNC: 80031   Entrez Gene: 112702   Ensembl: ENSG000001374047   UniProtKB: Q8IXM63   

Export aliases for NRM gene to outside databases

Previous GC identifers: GC06M030711 GC06M030426 GC06M030761 GC06M030763


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NRM Gene:
The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane,
where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine
carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode
different protein isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for NRM Gene: 
NRM (nurim (nuclear envelope membrane protein)) is a protein-coding gene. Diseases associated with NRM include lipodystrophy, and systemic lupus erythematosus. GO annotations related to this gene include molecular_function.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NRM gene promoter:
         GR   AP-1   ATF-2   GR-beta   STAT3   GR-alpha   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRM promoter sequence
   Search SABiosciences Chromatin IP Primers for NRM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

NRM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRM gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M030655:  view genomic region     (about GC identifiers)

Start:
30,655,824 bp from pter      End:
30,659,197 bp from pter
Size:
3,374 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167248 1,948,759-1,951,702      Chr6-,NT_167247 2,037,711-2,040,654      Chr6-,NT_167245 1,949,488-1,952,431     
Chr6-,NT_167244 1,967,472-1,970,415      Chr6-,NT_167246 2,003,922-2,006,865      Chr6-,NT_113891.2 2,167,899-2,170,842     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NRM_HUMAN, Q8IXM6 (See protein sequence)
Recommended Name: Nurim  
Size: 262 amino acids; 29379 Da
Subcellular location: Nucleus inner membrane; Multi-pass membrane protein
Secondary accessions: B0S7R0 B0S7R1 Q5JP57 Q5JP58 Q5JP59 Q5JP60 Q8WU45 Q9BSX3 Q9UN92
Alternative splicing: 2 isoforms:  Q8IXM6-1   Q8IXM6-2   

Explore the universe of human proteins at neXtProt for NRM: NX_Q8IXM6

Explore proteomics data for NRM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IXM6

  • NRM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NRM Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001257636.1  NP_001257637.1  NP_001257638.1  NP_001257639.1  NP_009174.1  

    ENSEMBL proteins: 
     ENSP00000397892   ENSP00000365602   ENSP00000259953   ENSP00000365603  

    Human Recombinant Protein Products for NRM: 
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    Novus Biologicals NRM Protein
    Novus Biologicals NRM Lysate
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for NRM 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA10402458
    GO:0005637nuclear inner membrane IEA--
    GO:0016021integral to membrane IEA--

    NRM for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for NRM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009915 NnrU

    Graphical View of Domain Structure for InterPro Entry Q8IXM6

    ProtoNet protein and cluster: Q8IXM6

    UniProtKB/Swiss-Prot: NRM_HUMAN, Q8IXM6
    Similarity: Belongs to the nurim family


    NRM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    NRM for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NRM:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NRM 
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    hsa-miR-125a-5p hsa-miR-4299 hsa-miR-3125 hsa-miR-3916 hsa-miR-3158-3p hsa-miR-544b hsa-miR-125b hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidNRM 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRM

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    NRM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NRM

    Search CenterWatch for drugs/clinical trials and news about NRM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NRM gene (5 alternative transcripts): 
    NM_001270707.1  NM_001270708.1  NM_001270709.1  NM_001270710.1  NM_007243.2  

    Unigene Cluster for NRM:

    Nurim (nuclear envelope membrane protein)
    Hs.519993  [show with all ESTs]
    Unigene Representative Sequence: NM_007243
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495946 ENST00000444096 ENST00000482141 ENST00000474864 ENST00000376420
    ENST00000462857 ENST00000470733 ENST00000259953(uc003nrc.3 uc003nre.3)
    ENST00000376421
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRM
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate NRM (see all 11):
    hsa-miR-125a-5p hsa-miR-4299 hsa-miR-3125 hsa-miR-3916 hsa-miR-3158-3p hsa-miR-544b hsa-miR-125b hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidNRM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NRM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRM
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                         Customized lentivirus expression plasmids for stable overexpression of NRM 
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    Additional mRNA sequence: 

    AF143676.1 AK075509.1 AK298152.1 AK315190.1 AY358411.1 BC004509.2 BC021260.1 BC039865.1 
    NR_073065.1 NR_073066.1 NR_073072.1 

    10 DOTS entries:

    DT.314022  DT.97858981  DT.100815657  DT.100815653  DT.121386396  DT.121386419  DT.91767632  DT.91767636 
    DT.97858980  DT.100815665 

    24/28 AceView cDNA sequences (see all 28):

    AY358411 CR616786 NM_007243 BC004509 BF839747 BC021260 BC039865 CR609683 
    CR592223 AK075509 CR604044 CR596567 CR604619 CR618359 CR619257 BX375665 
    CR623441 BX447254 CR606826 CR614897 CR597197 CR608026 AF143676 BX381388 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NRM (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                                            -     -           -     -                                                   
    SP2:                                            -     -                 -                                                   
    SP3:                                                  -           -     -                                                   
    SP4:                                            -     -                 -     -                                             
    SP5:                                            -     -           -     -     -                                             


    ECgene alternative splicing isoforms for NRM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NRM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTCTCCC
    NRM Expression
    About this image


    See NRM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NRM

    SOURCE GeneReport for Unigene cluster: Hs.519993
        SABiosciences Custom PCR Arrays for NRM
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NRM gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrm1 , 5 nurim (nuclear envelope membrane protein)1, 5 87.4(n)1
    94.27(a)1
      17 (18.72 cM)5
    1065821  NM_134122.21  NP_598883.11 
     358613185 
    lizard
    (Anolis carolinensis)
    Reptilia NRM6
    Uncharacterized protein
    59(a)
    1 ↔ 1
    2(191899771-191910091)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480584092   -- 73.29(n)    48058409 
    zebrafish
    (Danio rerio)
    Actinopterygii nrm1 nurim (nuclear envelope membrane protein 57.78(n)
    52.16(a)
      570027  NM_001045195.1  NP_001038660.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76551 CG7655 49.66(n)
    36.6(a)
      42128  NM_142389.2  NP_650646.1 


    ENSEMBL Gene Tree for NRM (if available)
    TreeFam Gene Tree for NRM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/52 SNPs in NRM are shown (see all 52)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406488601,2
    C--30657734(+) TTTGCC/GCCTCC 8 -- int10--------
    rs1156464021,2
    C--30658076(+) TGTTTC/TCCCCA 8 -- int11Minor allele frequency- T:0.01NA 120
    rs10754961,2
    C,F,A,H--30658239(-) ATGTGG/TTGTTC 8 -- int141Minor allele frequency- T:0.45MN NS EA NA WA CSA 4031
    rs1411506621,2
    --30658382(+) ACTCCC/GGTCAC 8 -- int1 nc-transcript-variant0--------
    rs22697031,2
    C,F,H--30658385(-) GCGGTG/AACCGG 8 -- int1 nc-transcript-variant21Minor allele frequency- A:0.06EA MN NS NA WA EU 4641
    rs1156655261,2
    C,F--30658445(+) TCCTTG/CAGTTC 8 -- int1 nc-transcript-variant1Minor allele frequency- C:0.02WA 118
    rs1140894711,2
    C,F--30658508(+) GTTCGA/TGTTCC 8 -- int1 nc-transcript-variant3Minor allele frequency- T:0.02WA NA EU 827
    rs1512608471,2
    C,F--30658739(+) GAGCAG/ATGCAG 13 /L nc-transcript-variantus2k1 syn11Minor allele frequency- A:0.00NA 4112
    rs1180465231,2
    C,F--30658905(+) CTTCCC/ACATCC 8 -- nc-transcript-variantus2k1 ut511Minor allele frequency- A:0.05EA 120
    rs1854098981,2
    --30658978(+) GTTAGA/CATCCC 8 -- us2k1 ut510--------

    HapMap Linkage Disequilibrium report for NRM (30655824 - 30659197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NRM:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670269CNV Deletion23128226
    esv2731791CNV Deletion23290073
    dgv6528n71CNV Loss21882294
    nsv884094CNV Loss21882294
    dgv6527n71CNV Loss21882294
    nsv830626CNV Loss17160897
    nsv884086CNV Gain21882294
    dgv1917e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for NRM:    About MalaCards
    lipodystrophy    systemic lupus erythematosus    tuberculosis    lupus erythematosus
    gastric cancer


    NRM for disorders           About GeneDecksing

    Genetic Association Database (GAD): NRM
    Human Genome Epidemiology (HuGE) Navigator: NRM (8 documents)

    Export disorders for NRM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NRM gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NRM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. (PubMed id 10402458)1, 2, 3 Rolls M.M.... Rapoport T.A. (1999)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    4. Early sorting of inner nuclear membrane proteins is c onserved. (PubMed id 17517639)1, 3 Braunagel S.C....Summers M.D. (2007)
    5. Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane. (PubMed id 15542857)1, 2 Hofemeister H. and O'Hare P. (2005)
    6. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. (PubMed id 23092226)1 Chen H.... Zhou R. (2012)
    7. Association of connexin43 with E3 ubiquitin ligase TRI M21 reveals a mechanism for gap junction phosphodegron control. (PubMed id 23106098)1 Chen V.C....Naus C.C. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Contribution of a haplotype in the HLA region to anti- cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, indepe ndently of HLA-DRB1. (PubMed id 19950296)4 Okada Y....Yamamoto K. (2009)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11270 HGNC: 8003 AceView: NRM Ensembl:ENSG00000137404 euGenes: HUgn11270
    ECgene: NRM H-InvDB: NRM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NRM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NRM gene:
    Search GeneIP for patents involving NRM

    GeneCards and IP:
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