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Aliases for NRM Gene

Aliases for NRM Gene

  • Nurim (Nuclear Envelope Membrane Protein) 2 3 5
  • Nuclear Rim Protein 3 4
  • NRM29 3 4
  • Nuclear Envelope Membrane Protein 4
  • Nurim 3

External Ids for NRM Gene

Previous GeneCards Identifiers for NRM Gene

  • GC06M030711
  • GC06M030426
  • GC06M030761
  • GC06M030763

Summaries for NRM Gene

Entrez Gene Summary for NRM Gene

  • The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for NRM Gene

NRM (Nurim (Nuclear Envelope Membrane Protein)) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRM Gene

Genomics for NRM Gene

Regulatory Elements for NRM Gene

Enhancers for NRM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G030678 1.9 FANTOM5 ENCODE dbSUPER 15.8 +6.1 6095 13.5 CREB3L1 MLX AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 IER3 HLA-E PPP1R18 PPP1R10 NRM MDC1 ABCF1 C6orf136 LINC00243 TRIM39-RPP21
GH06G030611 1.7 Ensembl ENCODE dbSUPER 13.1 +75.9 75868 8.7 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ABCF1 PPP1R10 RPL3P2 NRM TRIM26 MIR877 GTF2H4 C6orf136 DDX39B DHX16
GH06G030715 1.5 ENCODE dbSUPER 13.2 -28.1 -28107 7.7 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 DHX16 DDX39B LY6G5B ABCF1 PAIP1P1 PPP1R10 TRIM26 HLA-K HLA-F-AS1 RPL3P2
GH06G030746 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -60.0 -60008 9.5 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 IER3 DHX16 LY6G5B GTF2H4 DDX39B PPP1R10 PAIP1P1 ABCF1 HLA-K VARS2
GH06G030757 2.1 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -72.9 -72899 14.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 IER3 VARS2 DDR1 C6orf136 PPP1R18 FLOT1 HCG18 LINC00243 PRR3 TUBB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRM on UCSC Golden Path with GeneCards custom track

Promoters for NRM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195425 520 1001 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for NRM Gene

Chromosome:
6
Start:
30,688,047 bp from pter
End:
30,691,420 bp from pter
Size:
3,374 bases
Orientation:
Minus strand

Genomic View for NRM Gene

Genes around NRM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for NRM Gene

  • Protein details for NRM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXM6-NRM_HUMAN
    Recommended name:
    Nurim
    Protein Accession:
    Q8IXM6
    Secondary Accessions:
    • B0S7R0
    • B0S7R1
    • I3XIE2
    • I3XIE3
    • Q5JP57
    • Q5JP58
    • Q5JP59
    • Q5JP60
    • Q8WU45
    • Q9BSX3
    • Q9UN92

    Protein attributes for NRM Gene

    Size:
    262 amino acids
    Molecular mass:
    29379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRM Gene

Post-translational modifications for NRM Gene

  • Ubiquitination at posLast=121121, Lys184, and posLast=249249
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRM Gene

Domains & Families for NRM Gene

Protein Domains for NRM Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IXM6

UniProtKB/Swiss-Prot:

NRM_HUMAN :
  • Belongs to the nurim family.
Family:
  • Belongs to the nurim family.
genes like me logo Genes that share domains with NRM: view

No data available for Gene Families for NRM Gene

Function for NRM Gene

Gene Ontology (GO) - Molecular Function for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRM: view
genes like me logo Genes that share phenotypes with NRM: view

Animal Model Products

CRISPR Products

miRNA for NRM Gene

miRTarBase miRNAs that target NRM

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRM Gene

Localization for NRM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRM Gene

Nucleus inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRM gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IDA 10402458
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NRM: view

Pathways & Interactions for NRM Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRM: view

No data available for Pathways by source and SIGNOR curated interactions for NRM Gene

Drugs & Compounds for NRM Gene

No Compound Related Data Available

Transcripts for NRM Gene

Unigene Clusters for NRM Gene

Nurim (nuclear envelope membrane protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRM Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - -
SP8:
SP9: - - -

Relevant External Links for NRM Gene

GeneLoc Exon Structure for
NRM
ECgene alternative splicing isoforms for
NRM

Expression for NRM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRM Gene

mRNA differential expression in normal tissues according to GTEx for NRM Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for NRM Gene

This gene is overexpressed in Nasal epithelium (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRM Gene



Protein tissue co-expression partners for NRM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRM Gene:

NRM

SOURCE GeneReport for Unigene cluster for NRM Gene:

Hs.519993

Evidence on tissue expression from TISSUES for NRM Gene

  • Blood(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NRM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRM Gene

Orthologs for NRM Gene

This gene was present in the common ancestor of animals.

Orthologs for NRM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRM 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia NRM 34 35
  • 92.1 (n)
cow
(Bos Taurus)
Mammalia NRM 34 35
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Nrm 34 16 35
  • 87.68 (n)
rat
(Rattus norvegicus)
Mammalia Nrm 34
  • 87.15 (n)
oppossum
(Monodelphis domestica)
Mammalia NRM 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRM 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489431 34
  • 58.3 (n)
zebrafish
(Danio rerio)
Actinopterygii nrm 34 35
  • 58.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7655 34 35
  • 50.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005818 34
  • 45.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for NRM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRM Gene

ENSEMBL:
Gene Tree for NRM (if available)
TreeFam:
Gene Tree for NRM (if available)

Paralogs for NRM Gene

No data available for Paralogs for NRM Gene

Variants for NRM Gene

Sequence variations from dbSNP and Humsavar for NRM Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1002322612 -- 30,691,176(+) CTGTC(C/T)CTCCG upstream-variant-2KB, utr-variant-5-prime
rs1004005392 -- 30,692,238(+) CACGA(C/T)TGCTC upstream-variant-2KB
rs1004067064 -- 30,692,936(+) CAGTT(A/G)GATCA upstream-variant-2KB
rs1005031678 -- 30,688,402(+) CATGC(G/T)CTAAA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1005569430 -- 30,693,096(+) GTGGA(A/G)GTTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRM Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv2759413 CNV loss 17122850
esv3367670 CNV insertion 20981092
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for NRM Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRM Gene

Disorders for NRM Gene

Relevant External Links for NRM

Genetic Association Database (GAD)
NRM
Human Genome Epidemiology (HuGE) Navigator
NRM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRM

No disorders were found for NRM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRM Gene

Publications for NRM Gene

  1. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. (PMID: 10402458) Rolls M.M. … Rapoport T.A. (J. Cell Biol. 1999) 2 3 4 64
  2. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. (PMID: 23092226) Chen H. … Zhou R. (Curr. Mol. Med. 2012) 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. Early sorting of inner nuclear membrane proteins is conserved. (PMID: 17517639) Braunagel S.C. … Summers M.D. (Proc. Natl. Acad. Sci. U.S.A. 2007) 2 3 64

Products for NRM Gene

Sources for NRM Gene

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