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NRK Gene

protein-coding   GIFtS: 52
GCID: GC0XP105067

Nik Related Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nik Related Kinase1 2
EC 2.7.11.13 8
NESK2 5
Nik-Related Protein Kinase2
EC 2.7.118

External Ids:    HGNC: 253911   Entrez Gene: 2034472   Ensembl: ENSG000001235727   OMIM: 3007915   UniProtKB: Q7Z2Y53   

Export aliases for NRK gene to outside databases

Previous GC identifers: GC0XP103839 GC0XP104872 GC0XP094691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRK Gene:
The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be
involved in the induction of actin polymerization in late embryogenesis.(provided by RefSeq, Jun 2010)

GeneCards Summary for NRK Gene:
NRK (Nik related kinase) is a protein-coding gene. Diseases associated with NRK include hypermobility syndrome, and hyperinsulinemic hypoglycemia. GO annotations related to this gene include protein serine/threonine kinase activity and small GTPase regulator activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: NRK_HUMAN, Q7Z2Y5
Function: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages
of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity)

Gene Wiki entry for NRK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRK gene promoter:
         AP-1   ATF-2   CREB   AREB6   MZF-1   deltaCREB   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRK promoter sequence
   Search Chromatin IP Primers for NRK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

NRK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRK gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP105067:  view genomic region     (about GC identifiers)

Start:
105,066,536 bp from pter      End:
105,202,602 bp from pter
Size:
136,067 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NRK_HUMAN, Q7Z2Y5 (See protein sequence)
Recommended Name: Nik-related protein kinase  
Size: 1582 amino acids; 178479 Da
Secondary accessions: Q32ND6 Q5H9K2 Q6ZMP2
Alternative splicing: 3 isoforms:  Q7Z2Y5-1   Q7Z2Y5-2   Q7Z2Y5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NRK: NX_Q7Z2Y5

Explore proteomics data for NRK at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NRK (Q7Z2Y5) (see all 6)
     WMAPEVI  GTPYWMAPE  LNLLITISG  FIGTPYWMAPEV 


    See NRK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940867.2  
    ENSEMBL proteins: 
     ENSP00000434830   ENSP00000438378   ENSP00000438785   ENSP00000438148  

    NRK Human Recombinant Protein Products:

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    Novus Biologicals NRK Protein
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    Cloud-Clone Corp. CLIAs for NRK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Nik related kinase
    MSN subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR001180 Citron
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q7Z2Y5

    ProtoNet protein and cluster: Q7Z2Y5

    1 Blocks protein domain: IPB001180 Citron-like

    UniProtKB/Swiss-Prot: NRK_HUMAN, Q7Z2Y5
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 CNH domain
    Similarity: Contains 1 protein kinase domain


    NRK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRK_HUMAN, Q7Z2Y5
    Function: May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages
    of embryogenesis. Involved in the TNF-alpha-induced signaling pathway (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005083small GTPase regulator activity IEA--
         
    NRK for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NRK:
     Decreased CYP1A1 activity afte  Decreased focal adhesion (FA)   Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nrk):
     embryogenesis  mortality/aging  reproductive system 

    NRK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nrktm1Mkom for NRK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NRK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NRK

    miRNA
    Products:
        
    miRTarBase miRNAs that target NRK:
    hsa-mir-335-5p (MIRT018046)

    Block miRNA regulation of human, mouse, rat NRK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRK (see all 116):
    hsa-miR-323-3p hsa-miR-26a-2* hsa-miR-607 hsa-miR-1258 hsa-miR-128 hsa-miR-374a hsa-miR-30d hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidNRK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NRK
    Predesigned siRNA for gene silencing in human, mouse, rat NRK

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for NRK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NRK (NM_017719)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRK

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NRK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--

    NRK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NRK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF receptor signaling pathway
    TNF receptor signaling pathway


    1 BioSystems Pathway for NRK
        TNF receptor signaling pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRK
    Interactions:

        Search GeneGlobe Interaction Network for NRK

    1 Interacting protein for NRK (Q7Z2Y53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CFL1P235283I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007256activation of JNKK activity ----
    GO:0007567parturition ----
    GO:0008285negative regulation of cell proliferation ----
    GO:0023014signal transduction by phosphorylation IBA--

    NRK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NRK gene: 
    NM_198465.3  

    Unigene Cluster for NRK:

    Nik related kinase
    Hs.209527  [show with all ESTs]
    Unigene Representative Sequence: BX538345
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243300(uc004emd.3 uc011msi.2) ENST00000428173(uc010npc.1)
    ENST00000536164 ENST00000540278
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NRK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRK (see all 116):
    hsa-miR-323-3p hsa-miR-26a-2* hsa-miR-607 hsa-miR-1258 hsa-miR-128 hsa-miR-374a hsa-miR-30d hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidNRK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NRK
    Predesigned siRNA for gene silencing in human, mouse, rat NRK
    Clone
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    OriGene clones in human, mouse for NRK (see all 6)
    OriGene ORF clones in mouse, rat for NRK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NRK (NM_017719)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRK
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NRK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRK
      QuantiTect SYBR Green Assays in human, mouse, rat NRK
      QuantiFast Probe-based Assays in human, mouse, rat NRK

    Additional mRNA sequence: 

    AK131549.1 AK293500.1 AK300377.1 BC108702.1 BX538345.1 

    5 DOTS entries:

    DT.114556  DT.97777096  DT.121320158  DT.121320173  DT.121320168 

    Selected AceView cDNA sequences (see all 74):

    AI358516 AI917597 AI016408 AW664774 BQ181298 AI016565 AK131549 BQ771725 
    AA992147 AI803353 AI280290 AA779246 AW102594 AI209073 AA742454 AI473381 
    AW594026 BM683045 BQ774422 BX108491 R62577 CF593374 NM_198465 BX538345 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRK expression in normal human tissues (normalized intensities)      NRK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NRK Expression
    About this image


    NRK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
             TGFbeta3+BMP7-induced chondrocytes
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             Zeugopod
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             Extraocular Muscles
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             TGFbeta3+BMP7-induced chondrocytes
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
    NRK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.209527
        Custom PCR Arrays for NRK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NRK gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrk1 , 5 Nik related kinase1, 5 79.03(n)1
    71.03(a)1
      X (61.15 cM)5
    272061  NM_013724.21  NP_038752.21 
     1389144315 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-81j8.66
    si:dkey-81j8.6
    16(a)
    many ↔ many
    10(20689881-20708201) ENSDARG00000088831


    ENSEMBL Gene Tree for NRK (if available)
    TreeFam Gene Tree for NRK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRK gene
    TAOK22  MAP4K52  TAOK32  TNIK2  MAP4K22  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for NRK using alignment to 5 protein entries:     NRK_HUMAN (see all proteins) (see all similar genes):
    PAK4    MYO3A    STK24    MST4    STK4    MARK4
    STK3    MAP4K4    MAP3K2    DKFZp686J1430    NEK6    RPS6KA2
    STK11    STK25    MAP2K5    TNIK    CDK4    MINK1

    NRK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRK (see all 1651)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409564
    A colorectal adenocarcinoma sample4--see VAR_0409562 I L mis40--------
    VAR_0409524
    A breast infiltrating ductal carcinoma sample4--see VAR_0409522 S C mis40--------
    rs1908117201,2
    --94689985(+) CGCACC/TGGCCC 1 -- us2k10--------
    rs1808344861,2
    --94690047(+) GCCAGC/GCTCTT 1 -- us2k10--------
    rs1436861701,2
    C--94690669(+) TTGCAA/GCTAGT 1 -- us2k10--------
    rs1885847941,2
    --105034200(+) ACGGGA/GCATTT 1 -- us2k10--------
    rs2016831171,2
    --105034360(+) AATGT-/GTATGT 1 -- us2k10--------
    rs1811588301,2
    --105034633(+) TTTGGG/TGGAAG 1 -- us2k10--------
    rs169848451,2
    C,F,H--105034696(+) GAGACC/GCGGTT 1 -- us2k17Minor allele frequency- G:0.01NA NS EA 556
    rs1482379111,2
    --105034876(+) GTGGGA/GAGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NRK (105066536 - 105202602 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NRK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740368CNV Deletion23290073
    esv2676289CNV Deletion23128226
    esv2660063CNV Deletion23128226
    esv2140378CNV Deletion18987734
    esv2482028CNV Deletion19546169
    esv4419CNV Deletion18987735
    esv2636339CNV Deletion19546169
    esv2752312CNV Gain17911159
    nsv521259CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): NRK

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRK
    DNA2.0 Custom Variant and Variant Library Synthesis for NRK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300791    OMIM disorders: --

    7 diseases for NRK:    About MalaCards
    hypermobility syndrome    hyperinsulinemic hypoglycemia    sotos syndrome    hypoglycemia
    choroiditis    cerebritis    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for NRK:
    Hypermobility syndrome     Sotos syndrome

    NRK for disorders           About GeneDecksing


    Export disorders for NRK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRK gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with NRK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    5. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    8. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
    9. Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family. (PubMed id 12837278)1 Nakano K.... Kitamura N. (Exp. Cell Res. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 203447 HGNC: 25391 AceView: NRK Ensembl:ENSG00000123572 euGenes: HUgn203447
    ECgene: NRK H-InvDB: NRK

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRK gene:
    Search GeneIP for patents involving NRK

    GeneCards and IP:
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