NRIP3 Gene
protein-coding GIFtS : 47
GCID: GC11 M009001
nuclear receptor interacting protein 3 (Previous name: chromosome 11 open reading frame 14 ) (Previous symbol: C11orf14 )
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Aliasesfor NRIP3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Nuclear Receptor Interacting Protein 3 1 2 C11orf141 2 3 Sarcoma Antigen NY-SAR-1052 3 Chromosome 11 Open Reading Frame 141 NY-SAR-1052 Nuclear Receptor-Interacting Protein 32
Export aliases for NRIP3 gene to outside databases Previous GC identifers: GC11M009043 GC11M008968 GC11M008960 GC11M008673
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Summariesfor NRIP3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor NRIP3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NRIP3 gene promoter: ISGF-3 LHX3b/Lhx3b LUN-1 AREB6 CREB Ik-2 deltaCREB LHX3a/Lhx3a STAT3 ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for NRIP3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NRIP3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.3 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.3 NRIP3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M009001: view genomic region
(about GC identifiers )
Start:
9,002,123 bp from pter
End:
9,025,596 bp from pter
Size:
23,474 bases
Orientation:
minus strand
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Proteinsfor NRIP3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NRIP3_HUMAN, Q9NQ35 (See
protein sequence )Recommended Name: Nuclear receptor-interacting protein 3 Size : 241 amino acids; 26975 Da
Secondary accessions : Q86WD9Explore the universe of human proteins at neXtProt for NRIP3: NX_Q9NQ35 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NQ35 NRIP3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_065696.1 ENSEMBL proteins: ENSP00000310205 ENSP00000435785 ENSP00000432002 ENSP00000432451 ENSP00000433845 Human Recombinant Protein Products: NRIP3 Antibody Products: Assay Products for NRIP3:
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Protein
Domains / Familiesfor NRIP3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NRIP3 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NQ35 ProtoNet protein and cluster: Q9NQ35
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Functionfor NRIP3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NRIP3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NRIP3 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NRIP3 (NM_020645 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRIP3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NRIP3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP3
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004190 aspartic-type endopeptidase activity
IEA --
NRIP3 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for NRIP3 :
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Pathways & Interactionsfor NRIP3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRIP3 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for NRIP3 (ENSP00000310205 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006508 proteolysis
IEA --
NRIP3 for ontologies About GeneDecksing
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Drugs & Compoundsfor NRIP3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NRIP3 Search CenterWatch for drugs/clinical trials and news about NRIP3
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Transcriptsfor NRIP3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NRIP3 gene: NM_020645.2 Unigene Cluster for NRIP3:
Nuclear receptor interacting protein 3 Hs.523467 [show with all ESTs ] Unigene Representative Sequence: NM_020645 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000309166 (uc001mhg.2 ) ENST00000534759 ENST00000531142 ENST00000531090 (uc010rbu.1 )ENST00000525100 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NRIP3 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NRIP3 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NRIP3 (NM_020645 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRIP3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NRIP3
Additional cDNA sequence: AK024750.1 AK093229.1 AK098694.1 AK296484.1 AY211930.1 BC008835.2
4 DOTS entries : DT.213005 DT.95268744
DT.95268743 DT.95111301 24/87 AceView cDNA sequences (see all 87 ):
CA446775 R85059 AI123819 AA609577 BU632617 AI123829 AI248400 BX117508 AK098694 AI912608 CD370834 BP370720 AV728555 BX508197 AW013867 BU860655 AA609058 BI548996 BG717335 AA293782 BF979576 BP370332 AA928382 AA446522 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for NRIP3 About this scheme ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b SP1 :                     -       SP2 :         -   -   -               SP3 :   -                         SP4 :                           SP5 :                          
ECgene alternative splicing isoforms for NRIP3
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Expression for NRIP3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NRIP3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCTGACTCGG
About this image NRIP3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See NRIP3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NRIP3 SOURCE GeneReport for Unigene cluster: Hs.523467 SABiosciences Custom PCR Arrays for NRIP3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NRIP3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NRIP3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NRIP3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NRIP3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP3
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Orthologsfor NRIP3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for NRIP3 gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
NRIP31
nuclear receptor interacting protein 3
67.22(n) 64.58(a)
 
423050 XM_420983.3 XP_420983.3
lizard (Anolis carolinensis)
Reptilia
NRIP36
--
67(a)
1 ↔ 1
1(64441962-64476919)
zebrafish (Danio rerio)
Actinopterygii
nrip26
nuclear receptor interacting protein 2
30(a)
1 → many
4(16640679-16697628)
ENSEMBL Gene Tree for NRIP3 (if available)TreeFam Gene Tree for NRIP3 (if available)
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Paralogsfor NRIP3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NRIP3 gene NRIP2 2 1 SIMAP similar gene for NRIP3 using alignment to 5 protein entries: NRIP3_HUMAN (see all proteins ):NRIP2
NRIP3 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for NRIP3 PGOHUM00000257922
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Genomic Variantsfor NRIP3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for NRIP3 (9002123 - 9025596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for NRIP3 2 CNVs : 3837 6953
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor NRIP3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NRIP3 for disorders About GeneDecksing
OMIM gene information: 613125
OMIM disorders : --4 diseases for NRIP3 : About MalaCards sarcoma acute myeloid leukemia myeloid leukemia leukemia Export disorders for NRIP3 gene to outside databases
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Publicationsfor NRIP3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NRIP3 gene integrated from 9 sources : (articles sorted by number of sources associating them with NRIP3) Utopia : connect your pdf to the dynamic world of online information
Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127) 1 , 2 , 3 Amid C.... Schmidt E.R. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Immunomic analysis of human sarcoma. (PubMed id 12601173) 1 , 2 Lee S.-Y.... Scanlan M.J. (2003) NRIP3: a novel translocation partner of MLL detected in a pediatric acute myeloid leukemia with complex chromosome 11 rearrangements . (PubMed id 19454493) 1 Balgobind B.V....Van den Heuvel-Eibrink M.M. (2009) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 Abdelmohsen K....Gorospe M. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NRIP3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NRIP3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NRIP3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing NRIP3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NRIP3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NRIP3 gene: Search GeneIP for patents involving NRIP3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NRIP3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for NRIP3 OriGene shRNA RFP for NRIP3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NRIP3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NRIP3 OriGene Protein Over-expression Lysate for NRIP3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NRIP3 OriGene 3'-UTR Clone for NRIP3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NRIP3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NRIP3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for NRIP3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NRIP3 OriGene Custom Protein Services for NRIP3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NRIP3 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRIP3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NRIP3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NRIP3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NRIP3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NRIP3
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NRIP3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP3
ThermoFisher Antibodies for NRIP3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NRIP3
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