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Aliases for NRIP2 Gene

Aliases for NRIP2 Gene

  • Nuclear Receptor Interacting Protein 2 2 3 5

External Ids for NRIP2 Gene

Previous GeneCards Identifiers for NRIP2 Gene

  • GC12M002813
  • GC12M002935

Summaries for NRIP2 Gene

GeneCards Summary for NRIP2 Gene

NRIP2 (Nuclear Receptor Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is NRIP3.

UniProtKB/Swiss-Prot for NRIP2 Gene

  • Down-regulates transcriptional activation by nuclear receptors such as NR1F2.

Gene Wiki entry for NRIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRIP2 Gene

Genomics for NRIP2 Gene

Regulatory Elements for NRIP2 Gene

Enhancers for NRIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NRIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRIP2 Gene

2,824,882 bp from pter
2,835,544 bp from pter
10,663 bases
Minus strand

Genomic View for NRIP2 Gene

Genes around NRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRIP2 Gene

Proteins for NRIP2 Gene

  • Protein details for NRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear receptor-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • A2RRE3
    • B4DV61

    Protein attributes for NRIP2 Gene

    281 amino acids
    Molecular mass:
    31331 Da
    Quaternary structure:
    • Interacts with NR1F2, RARA and THRB in a ligand-dependent manner.

    Alternative splice isoforms for NRIP2 Gene


neXtProt entry for NRIP2 Gene

Proteomics data for NRIP2 Gene at MOPED

Post-translational modifications for NRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRIP2 Gene

Domains & Families for NRIP2 Gene

Protein Domains for NRIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRIP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NRIP2 Gene

Function for NRIP2 Gene

Molecular function for NRIP2 Gene

UniProtKB/Swiss-Prot Function:
Down-regulates transcriptional activation by nuclear receptors such as NR1F2.
genes like me logo Genes that share phenotypes with NRIP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRIP2 Gene

Localization for NRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRIP2 Gene

Subcellular locations from

Jensen Localization Image for NRIP2 Gene COMPARTMENTS Subcellular localization image for NRIP2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NRIP2 Gene

Pathways & Interactions for NRIP2 Gene

SuperPathways for NRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with NRIP2: view

No data available for Pathways by source and SIGNOR curated interactions for NRIP2 Gene

Drugs & Compounds for NRIP2 Gene

No Compound Related Data Available

Transcripts for NRIP2 Gene

mRNA/cDNA for NRIP2 Gene

Unigene Clusters for NRIP2 Gene

Nuclear receptor interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRIP2 Gene

No ASD Table

Relevant External Links for NRIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRIP2 Gene

mRNA expression in normal human tissues for NRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRIP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.1), Brain - Cerebellum (x6.6), and Nerve - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for NRIP2 Gene

This gene is overexpressed in Stomach (15.8), Heart (14.5), Uterus (12.4), and Gallbladder (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRIP2 Gene

SOURCE GeneReport for Unigene cluster for NRIP2 Gene Hs.530816

genes like me logo Genes that share expression patterns with NRIP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NRIP2 Gene

Orthologs for NRIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NRIP2 35
  • 80.78 (n)
  • 73.72 (a)
NRIP2 36
  • 71 (a)
(Canis familiaris)
Mammalia NRIP2 35
  • 87.7 (n)
  • 82.4 (a)
NRIP2 36
  • 79 (a)
(Mus musculus)
Mammalia Nrip2 35
  • 86.03 (n)
  • 83.41 (a)
Nrip2 16
Nrip2 36
  • 62 (a)
(Pan troglodytes)
Mammalia NRIP2 35
  • 99.53 (n)
  • 98.58 (a)
NRIP2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nrip2 35
  • 85.3 (n)
  • 81.22 (a)
(Monodelphis domestica)
Mammalia NRIP2 36
  • 62 (a)
(Danio rerio)
Actinopterygii nrip2 35
  • 61.2 (n)
  • 58.47 (a)
nrip2 36
  • 36 (a)
Species with no ortholog for NRIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRIP2 Gene

Gene Tree for NRIP2 (if available)
Gene Tree for NRIP2 (if available)

Paralogs for NRIP2 Gene

Paralogs for NRIP2 Gene

(1) SIMAP similar genes for NRIP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRIP2: view

Variants for NRIP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NRIP2 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV Loss 17160897
nsv832311 CNV Loss 17160897

Variation tolerance for NRIP2 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for NRIP2 Gene

Disorders for NRIP2 Gene

Relevant External Links for NRIP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRIP2 Gene

Publications for NRIP2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Composition and three-dimensional EM structure of double affinity- purified, human prespliceosomal A complexes. (PMID: 17332742) Behzadnia N. … Luehrmann R. (EMBO J. 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for NRIP2 Gene

Sources for NRIP2 Gene