NRIP2 Gene
protein-coding GIFtS: 47
GCID: GC12M002935
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nuclear receptor interacting protein 2
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Aliases
for NRIP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Interacting Protein 21 2 | | DKFZP761G19131 | | Nuclear Receptor-Interacting Protein 22 |
Export aliases for NRIP2 gene to outside databasesPrevious GC identifers: GC12M002813 GC12M002804 |
Summaries
for NRIP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NRIP2_HUMAN, Q9BQI9Function: Down-regulates transcriptional activation by nuclear receptors such as NR1F2 (By similarity)
Gene Wiki entry for NRIP2
|
Genomic Views
for NRIP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NRIP2 gene promoter:
c-Fos NF-1/L NF-1 AP-1 HTF Fra-1 FosB GATA-2 HFH-1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for NRIP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRIP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.33 Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p13.33NRIP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M002935: view genomic region
(about GC identifiers)
Start:
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2,934,514 bp from pter |
End:
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2,944,710 bp from pter |
Size:
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10,197 bases |
Orientation:
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minus strand |
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Proteins
for NRIP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NRIP2_HUMAN, Q9BQI9 (See
protein sequence)Recommended Name: Nuclear receptor-interacting protein 2 Size: 281 amino acids; 31331 Da
Subunit: Interacts with NR1F2, RARA and THRB in a ligand-dependent manner (By similarity)
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for NRIP2: NX_Q9BQI9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BQI9
NRIP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_113662.1
ENSEMBL proteins: ENSP00000337501 ENSP00000446283 ENSP00000438338
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NRIP2 for ontologies About GeneDecksing
NRIP2 Antibody Products:
Assay Products for NRIP2: |
Protein
Domains /
Families
for NRIP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NRIP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BQI9ProtoNet protein and cluster: Q9BQI9 |
Function
for NRIP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NRIP2_HUMAN, Q9BQI9Function: Down-regulates transcriptional activation by nuclear receptors such as NR1F2 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRIP2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRIP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NRIP2 (NM_031474) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRIP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRIP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004190 | aspartic-type endopeptidase activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
NRIP2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NRIP2:
|
Pathways & Interactions
for NRIP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRIP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for NRIP2 (Q9BQI92, 3 ENSP000003375014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006508 | proteolysis |
IEA | -- |
NRIP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NRIP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NRIP2
Search CenterWatch for drugs/clinical trials and news about NRIP2
|
Transcripts
for NRIP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NRIP2 gene: NM_031474.2 Unigene Cluster for NRIP2: Nuclear receptor interacting protein 2 Hs.530816 [show with all ESTs]Unigene Representative Sequence: NM_0314743 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000337508(uc001qlc.3 uc010sed.1) ENST00000542990 ENST00000542386
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRIP2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRIP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NRIP2 (NM_031474) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NRIP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRIP2 |
Additional cDNA sequence: AK054740.1 AL136557.1 BC036063.1 BC131562.1 2 DOTS entries: DT.40211045 DT.100018073 18 AceView cDNA sequences: NM_031474 AK098063 CA397932 CD518404 AK054740 AL136557 BP362674 AA297081 AA322737 BC036063 BI553579 BF370439 AW138498 BQ327862 AA367570 AI184847 BF747530 BQ329091
GeneLoc Exon Structure
|
Expression
for NRIP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NRIP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTAGGAGT
About this image
See NRIP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NRIP2
SOURCE GeneReport for Unigene cluster: Hs.530816
SABiosciences Custom PCR Arrays for NRIP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRIP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NRIP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRIP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRIP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP2 |
Orthologs
for NRIP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NRIP2 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for NRIP2 (if available)
TreeFam Gene Tree for NRIP2 (if available) |
Paralogs
for NRIP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NRIP2 gene
- NRIP32
1 SIMAP similar gene for NRIP2 using alignment to 4 protein entries: NRIP2_HUMAN (see all proteins):NRIP3
NRIP2 for paralogs About GeneDecksing
|
Genomic Variants
for NRIP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NRIP2 (2934514 - 2944710 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NRIP2
1 CNV: 4766 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRIP2 |
|
Disorders
/ Diseases
for NRIP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NRIP2 for disorders About GeneDecksing
2  diseases for NRIP2: About MalaCardsasthma neuronitis
Human Genome Epidemiology (HuGE) Navigator: NRIP2 (1 document)
Export disorders for NRIP2 gene to outside databases
|
Publications
for NRIP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NRIP2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with NRIP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. (PubMed id 17332742)1 Behzadnia N.... Luehrmann R. (2007)
- Association of the RIP2 gene with childhood atopic asthma. (PubMed id 17075290)1 Nakashima K....Tamari M. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NRIP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NRIP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NRIP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NRIP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NRIP2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NRIP2 gene:
Search GeneIP for patents involving NRIP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NRIP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NRIP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRIP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NRIP2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NRIP2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NRIP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRIP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NRIP2 | | OriGene Custom Protein Services for NRIP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NRIP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NRIP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRIP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRIP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRIP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRIP2 |
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| | | | Search Tocris compounds for NRIP2 |
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 | | | NRIP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP2 |
|  |  |  | | | | Search ThermoFisher Antibodies for NRIP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRIP2 |
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