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Aliases for NRIP2 Gene

Aliases for NRIP2 Gene

  • Nuclear Receptor Interacting Protein 2 2 3

External Ids for NRIP2 Gene

Previous GeneCards Identifiers for NRIP2 Gene

  • GC12M002813
  • GC12M002935

Summaries for NRIP2 Gene

GeneCards Summary for NRIP2 Gene

NRIP2 (Nuclear Receptor Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is NRIP3.

UniProtKB/Swiss-Prot for NRIP2 Gene

  • Down-regulates transcriptional activation by nuclear receptors such as NR1F2.

Gene Wiki entry for NRIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRIP2 Gene

Genomics for NRIP2 Gene

Regulatory Elements for NRIP2 Gene

Genomic Location for NRIP2 Gene

Start:
2,825,348 bp from pter
End:
2,835,544 bp from pter
Size:
10,197 bases
Orientation:
Minus strand

Genomic View for NRIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRIP2 Gene

Proteins for NRIP2 Gene

  • Protein details for NRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQI9-NRIP2_HUMAN
    Recommended name:
    Nuclear receptor-interacting protein 2
    Protein Accession:
    Q9BQI9
    Secondary Accessions:
    • A2RRE3
    • B4DV61

    Protein attributes for NRIP2 Gene

    Size:
    281 amino acids
    Molecular mass:
    31331 Da
    Quaternary structure:
    • Interacts with NR1F2, RARA and THRB in a ligand-dependent manner.

    Alternative splice isoforms for NRIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRIP2 Gene

Proteomics data for NRIP2 Gene at MOPED

Post-translational modifications for NRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRIP2 Gene

Domains for NRIP2 Gene

Protein Domains for NRIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRIP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NRIP2 Gene

Function for NRIP2 Gene

Molecular function for NRIP2 Gene

UniProtKB/Swiss-Prot Function: Down-regulates transcriptional activation by nuclear receptors such as NR1F2.

Gene Ontology (GO) - Molecular Function for NRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRIP2: view

Phenotypes for NRIP2 Gene

GenomeRNAi human phenotypes for NRIP2:
genes like me logo Genes that share phenotypes with NRIP2: view

Animal Model Products

CRISPR Products

miRNA for NRIP2 Gene

miRTarBase miRNAs that target NRIP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NRIP2 Gene

Localization for NRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRIP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRIP2 Gene COMPARTMENTS Subcellular localization image for NRIP2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NRIP2: view

Pathways for NRIP2 Gene

SuperPathways for NRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with NRIP2: view

No data available for Pathways by source for NRIP2 Gene

Transcripts for NRIP2 Gene

mRNA/cDNA for NRIP2 Gene

Unigene Clusters for NRIP2 Gene

Nuclear receptor interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRIP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NRIP2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRIP2 Gene

No ASD Table

Relevant External Links for NRIP2 Gene

GeneLoc Exon Structure for
NRIP2
ECgene alternative splicing isoforms for
NRIP2

Expression for NRIP2 Gene

mRNA expression in normal human tissues for NRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRIP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (7.1), Brain - Cerebellum (6.6), and Nerve - Tibial (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NRIP2 Gene

SOURCE GeneReport for Unigene cluster for NRIP2 Gene Hs.530816

genes like me logo Genes that share expressions with NRIP2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NRIP2 Gene

Orthologs for NRIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRIP2 35
  • 99.53 (n)
  • 98.58 (a)
NRIP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRIP2 35
  • 80.78 (n)
  • 73.72 (a)
NRIP2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRIP2 35
  • 87.7 (n)
  • 82.4 (a)
NRIP2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrip2 35
  • 86.03 (n)
  • 83.41 (a)
Nrip2 16
Nrip2 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRIP2 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrip2 35
  • 85.3 (n)
  • 81.22 (a)
zebrafish
(Danio rerio)
Actinopterygii nrip2 35
  • 61.2 (n)
  • 58.47 (a)
nrip2 36
  • 36 (a)
OneToOne
Species with no ortholog for NRIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRIP2 Gene

ENSEMBL:
Gene Tree for NRIP2 (if available)
TreeFam:
Gene Tree for NRIP2 (if available)

Paralogs for NRIP2 Gene

Paralogs for NRIP2 Gene

Selected SIMAP similar genes for NRIP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRIP2: view

Variants for NRIP2 Gene

Sequence variations from dbSNP and Humsavar for NRIP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7301350 -- 2,834,476(+) ACATC(C/T)CCGGT intron-variant
rs7301367 -- 2,834,531(+) GGGAG(C/T)GGGAC intron-variant
rs7307516 -- 2,831,697(+) ATTCT(A/G)TAAGT intron-variant
rs10848710 -- 2,832,561(+) ACCCT(C/G)TCCAG intron-variant
rs11062372 -- 2,833,678(+) TTCCA(C/G)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRIP2 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV Loss 17160897
nsv832311 CNV Loss 17160897

Relevant External Links for NRIP2 Gene

HapMap Linkage Disequilibrium report
NRIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRIP2 Gene

Disorders for NRIP2 Gene

Relevant External Links for NRIP2

Genetic Association Database (GAD)
NRIP2
Human Genome Epidemiology (HuGE) Navigator
NRIP2
genes like me logo Genes that share disorders with NRIP2: view

No data available for UniProtKB/Swiss-Prot for NRIP2 Gene

Publications for NRIP2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association of the RIP2 gene with childhood atopic asthma. (PMID: 17075290) Nakashima K. … Tamari M. (Allergol Int 2006) 3 48
  5. Composition and three-dimensional EM structure of double affinity- purified, human prespliceosomal A complexes. (PMID: 17332742) Behzadnia N. … Luehrmann R. (EMBO J. 2007) 3

Products for NRIP2 Gene

Sources for NRIP2 Gene

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