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Aliases for NRIP1 Gene

Aliases for NRIP1 Gene

  • Nuclear Receptor Interacting Protein 1 2 3 5
  • Nuclear Factor RIP140 2 3 4
  • Receptor-Interacting Protein 140 3 4
  • Nuclear Receptor-Interacting Protein 1 3
  • Receptor Interacting Protein 140 2
  • RIP140 3

External Ids for NRIP1 Gene

Previous GeneCards Identifiers for NRIP1 Gene

  • GC21M012997
  • GC21M015255
  • GC21M016333
  • GC21M001716

Summaries for NRIP1 Gene

Entrez Gene Summary for NRIP1 Gene

  • Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRIP1 Gene

NRIP1 (Nuclear Receptor Interacting Protein 1) is a Protein Coding gene. Diseases associated with NRIP1 include Embryonal Carcinoma and Infertility. Among its related pathways are Aryl Hydrocarbon Receptor and Ovarian Infertility Genes. Gene Ontology (GO) annotations related to this gene include receptor binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for NRIP1 Gene

  • Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.

Gene Wiki entry for NRIP1 Gene

Additional gene information for NRIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRIP1 Gene

Genomics for NRIP1 Gene

GeneHancer (GH) Regulatory Elements for NRIP1 Gene

Promoters and enhancers for NRIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I015048 Promoter/Enhancer 3.1 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.1 +8.1 8116 18.2 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B FOS SP3 NRIP1 ENSG00000236471 ENSG00000279390
GH21I015439 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.4 -377.3 -377314 7.1 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 SLC30A9 NRIP1 ENSG00000236471 GC21P015441 CYCSP42 LOC105369302 LOC101927745
GH21I015437 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 16.1 -372.1 -372135 0.3 BMI1 BATF IRF4 RELA FOSL1 POLR2A NFATC1 ATF7 ETV6 IKZF2 NRIP1 ENSG00000236471 USP25 GC21P015441 ENSG00000280082 LOC101927745 LOC105369302
GH21I015208 Enhancer 1.4 Ensembl ENCODE dbSUPER 13.8 -144.2 -144187 4 CLOCK FOXA2 MLX ARID4B NEUROD1 DMAP1 ZBTB7B YY1 FOS DEK NRIP1 GC21P015201 LOC105369292
GH21I015221 Enhancer 1.4 FANTOM5 Ensembl ENCODE 13.3 -157.6 -157631 4 FOXA2 ARID4B SIN3A DMAP1 BRCA1 ZNF48 SLC30A9 FOS RXRA SP5 NRIP1 GC21P015201 LOC105369292
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NRIP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRIP1 gene promoter:

Genomic Locations for NRIP1 Gene

Genomic Locations for NRIP1 Gene
chr21:14,961,235-15,065,936
(GRCh38/hg38)
Size:
104,702 bases
Orientation:
Minus strand
chr21:16,333,556-16,437,321
(GRCh37/hg19)

Genomic View for NRIP1 Gene

Genes around NRIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRIP1 Gene

Proteins for NRIP1 Gene

  • Protein details for NRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48552-NRIP1_HUMAN
    Recommended name:
    Nuclear receptor-interacting protein 1
    Protein Accession:
    P48552
    Secondary Accessions:
    • Q8IWE8

    Protein attributes for NRIP1 Gene

    Size:
    1158 amino acids
    Molecular mass:
    126942 Da
    Quaternary structure:
    • Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1 (By similarity). Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366. Interacts with RORA.

    Three dimensional structures from OCA and Proteopedia for NRIP1 Gene

neXtProt entry for NRIP1 Gene

Post-translational modifications for NRIP1 Gene

  • Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.
  • Ubiquitination at isoforms=1115

No data available for DME Specific Peptides for NRIP1 Gene

Domains & Families for NRIP1 Gene

Gene Families for NRIP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NRIP1 Gene

Suggested Antigen Peptide Sequences for NRIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48552

UniProtKB/Swiss-Prot:

NRIP1_HUMAN :
  • Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homodimers and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding.
Domain:
  • Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homodimers and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding.
genes like me logo Genes that share domains with NRIP1: view

Function for NRIP1 Gene

Molecular function for NRIP1 Gene

GENATLAS Biochemistry:
nuclear receptor interacting protein,widely expressed,modulating transcriptional activation by the estrogen receptor
UniProtKB/Swiss-Prot Function:
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.
UniProtKB/Swiss-Prot Induction:
Expressed in a circadian manner in the liver (at protein level).

Phenotypes From GWAS Catalog for NRIP1 Gene

Gene Ontology (GO) - Molecular Function for NRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IDA 21628546
GO:0003712 transcription cofactor activity IEA --
GO:0003713 transcription coactivator activity NAS 15572661
GO:0003714 transcription corepressor activity IDA 10364267
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with NRIP1: view
genes like me logo Genes that share phenotypes with NRIP1: view

Animal Models for NRIP1 Gene

MGI Knock Outs for NRIP1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRIP1 Gene

Localization for NRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRIP1 Gene

Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRIP1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IEA --
GO:0000790 nuclear chromatin IDA 15831516
GO:0005634 nucleus IDA 7641693
GO:0005730 nucleolus IDA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with NRIP1: view

Pathways & Interactions for NRIP1 Gene

genes like me logo Genes that share pathways with NRIP1: view

SIGNOR curated interactions for NRIP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10364267
GO:0001543 ovarian follicle rupture IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with NRIP1: view

Drugs & Compounds for NRIP1 Gene

(8) Drugs for NRIP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE Experimental Pharma Target 0

(6) Additional Compounds for NRIP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRIP1: view

Transcripts for NRIP1 Gene

Unigene Clusters for NRIP1 Gene

Nuclear receptor interacting protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRIP1 Gene

No ASD Table

Relevant External Links for NRIP1 Gene

GeneLoc Exon Structure for
NRIP1
ECgene alternative splicing isoforms for
NRIP1

Expression for NRIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRIP1 Gene

mRNA differential expression in normal tissues according to GTEx for NRIP1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for NRIP1 Gene

This gene is overexpressed in Adrenal (65.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRIP1 Gene



Protein tissue co-expression partners for NRIP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRIP1 Gene:

NRIP1

SOURCE GeneReport for Unigene cluster for NRIP1 Gene:

Hs.155017

Evidence on tissue expression from TISSUES for NRIP1 Gene

  • Adrenal gland(5)
  • Blood(5)
  • Eye(5)
  • Gall bladder(5)
  • Heart(5)
  • Intestine(5)
  • Liver(5)
  • Lung(5)
  • Pancreas(5)
  • Nervous system(5)
  • Skin(4.1)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with NRIP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRIP1 Gene

Orthologs for NRIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRIP1 33 34
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia NRIP1 33 34
  • 88.09 (n)
rat
(Rattus norvegicus)
Mammalia Nrip1 33
  • 83.9 (n)
mouse
(Mus musculus)
Mammalia Nrip1 33 16 34
  • 83.12 (n)
dog
(Canis familiaris)
Mammalia NRIP1 33 34
  • 80.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NRIP1 34
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRIP1 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRIP1 33 34
  • 76.09 (n)
lizard
(Anolis carolinensis)
Reptilia NRIP1 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrip1 33
  • 61 (n)
Str.17425 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68665 33
zebrafish
(Danio rerio)
Actinopterygii nrip1b 33 34
  • 50.51 (n)
nrip1a 34
  • 34 (a)
OneToMany
Species where no ortholog for NRIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRIP1 Gene

ENSEMBL:
Gene Tree for NRIP1 (if available)
TreeFam:
Gene Tree for NRIP1 (if available)

Paralogs for NRIP1 Gene

(2) SIMAP similar genes for NRIP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NRIP1: view

No data available for Paralogs for NRIP1 Gene

Variants for NRIP1 Gene

Sequence variations from dbSNP and Humsavar for NRIP1 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs796052182 likely-benign, Long QT syndrome 14,967,553(-) T/C coding_sequence_variant, missense_variant
rs1000009610 -- 15,038,384(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000023839 -- 14,977,430(-) A/G intron_variant
rs1000074327 -- 15,038,703(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000078387 -- 15,020,913(-) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRIP1 Gene

Variant ID Type Subtype PubMed ID
esv1064466 CNV deletion 17803354
esv1174346 CNV deletion 17803354
esv1672496 CNV deletion 17803354
esv22747 CNV loss 19812545
esv2565555 CNV insertion 19546169
esv2664247 CNV deletion 23128226
esv2723186 CNV deletion 23290073
esv2723187 CNV deletion 23290073
esv3330601 CNV insertion 20981092
esv3424748 CNV duplication 20981092
esv3646440 CNV loss 21293372
nsv1071744 CNV deletion 25765185
nsv1152198 CNV insertion 26484159
nsv517307 CNV gain 19592680
nsv527611 CNV loss 19592680
nsv587050 CNV loss 21841781
nsv834048 CNV gain 17160897
nsv953342 CNV duplication 24416366

Variation tolerance for NRIP1 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRIP1 Gene

Human Gene Mutation Database (HGMD)
NRIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRIP1 Gene

Disorders for NRIP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NRIP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
infertility
- elite association - COSMIC cancer census association via MalaCards
Search NRIP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRIP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NRIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRIP1 Gene

Publications for NRIP1 Gene

  1. Preliminary molecular genetic analysis of the Receptor Interacting Protein 140 (RIP140) in women affected by endometriosis. (PMID: 16131398) Caballero V … Ruiz A (Journal of experimental & clinical assisted reproduction 2005) 3 4 22 44 58
  2. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. (PMID: 7641693) Cavaillès V … Parker MG (The EMBO journal 1995) 2 3 4 22 58
  3. Modulation of testicular receptor 4 activity by mitogen-activated protein kinase-mediated phosphorylation. (PMID: 16887930) Huq MD … Wei LN (Molecular & cellular proteomics : MCP 2006) 3 4 22 58
  4. Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. (PMID: 14736873) Christian M … Parker MG (The Journal of biological chemistry 2004) 3 4 22 58
  5. Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. (PMID: 15060175) Castet A … Cavaillès V (Nucleic acids research 2004) 3 4 22 58

Products for NRIP1 Gene

Sources for NRIP1 Gene

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