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NRIP1 Gene

protein-coding   GIFtS: 64
GCID: GC21M016333

Nuclear Receptor Interacting Protein 1

  See NRIP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Nuclear Receptor Interacting Protein 11 2
Nuclear Factor RIP1402 3 11
Receptor Interacting Protein 1401 2
Receptor-Interacting Protein 1402 3
RIP1402 5
Nuclear Receptor-Interacting Protein 12

External Ids:    HGNC: 80011   Entrez Gene: 82042   Ensembl: ENSG000001805307   OMIM: 6024905   UniProtKB: P485523   

Export aliases for NRIP1 gene to outside databases

Previous GC identifers: GC21M012997 GC21M015255 GC21M001716


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRIP1 Gene:
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the
hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates
transcriptional activity of the estrogen receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for NRIP1 Gene:
NRIP1 (nuclear receptor interacting protein 1) is a protein-coding gene. Diseases associated with NRIP1 include granuloma inguinale. GO annotations related to this gene include histone deacetylase binding and transcription coactivator activity.

UniProtKB/Swiss-Prot: NRIP1_HUMAN, P48552
Function: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates
transcriptional repression by nuclear hormone receptors

Gene Wiki entry for NRIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRIP1 gene promoter:
         ISGF-3   Spz1   NF-YA   Nkx2-5   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRIP1 promoter sequence

   Search Chromatin IP Primers for NRIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11.2   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q11.2
Nature(405: 311-319) cytogenetic band:   21q11
NRIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRIP1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M016333:   GeneLoc Nature:405,311-319
Start:
16,333,556 bp from pter       1,997,831 bp from centromere
End:
16,437,321 bp from pter 2,005,069 bp from centromere
Size:
103,766 bases 7,239 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: X84373
genomic clones: P30P13 P270M7


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NRIP1_HUMAN, P48552 (See protein sequence)
Recommended Name: Nuclear receptor-interacting protein 1  
Size: 1158 amino acids; 126942 Da
Subunit: Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts
with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding
domain); the interaction results in promoting the repressor activity of NR2C1 (By similarity). Interacts with
CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with
both NR3C1 and YWHAH. Interacts with ZNF366
2 PDB 3D structures from and Proteopedia for NRIP1:
2GPO (3D)        2GPP (3D)    
Secondary accessions: Q8IWE8

Explore the universe of human proteins at neXtProt for NRIP1: NX_P48552

Explore proteomics data for NRIP1 at MOPED

Post-translational modifications: 

  • Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes
    interaction with CTBP1. Phosphorylation enhances interaction with YWHAH1
  • Ubiquitination2 at Lys1115
  • Modification sites at PhosphoSitePlus

  • See NRIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003480.2  
    ENSEMBL proteins: 
     ENSP00000383060   ENSP00000383063   ENSP00000412114   ENSP00000327213  

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    Cloud-Clone Corp. Proteins for NRIP1

     
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    Search eBioscience for ELISAs for NRIP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026649 NRIP1

    Graphical View of Domain Structure for InterPro Entry P48552

    ProtoNet protein and cluster: P48552

    UniProtKB/Swiss-Prot: NRIP1_HUMAN, P48552
    Domain: Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The
    C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homodimers and
    heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By
    similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone
    deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent
    mechanisms, depending on cell type. RD2 is dependent on CTBP binding


    Find genes that share domains with NRIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRIP1_HUMAN, P48552
    Function: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates
    transcriptional repression by nuclear hormone receptors

         Genatlas biochemistry entry for NRIP1:
    nuclear receptor interacting protein,widely expressed,modulating transcriptional activation by the estrogen
    receptor

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0003714transcription corepressor activity IDA10364267
    GO:0005102receptor binding ----
    GO:0005515protein binding IPI1266503
    GO:0030331estrogen receptor binding IPI7641693
         
    Find genes that share ontologies with NRIP1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nrip1):
     endocrine/exocrine gland  growth/size/body  reproductive system 

    Find genes that share phenotypes with NRIP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRIP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NRIP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRIP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NRIP1

    miRNA
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    miRTarBase miRNAs that target NRIP1:
    hsa-mir-615-3p (MIRT040328), hsa-mir-24-3p (MIRT030442), hsa-mir-590-3p (MIRT016179), hsa-mir-15b-5p (MIRT046539)

    Block miRNA regulation of human, mouse, rat NRIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRIP1 (see all 97):
    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-30a hsa-miR-208b hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidNRIP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NRIP1
    Predesigned siRNA for gene silencing in human, mouse, rat NRIP1

    Gene Editing
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    OriGene clones in human, mouse for NRIP1 (see all 7)
    OriGene ORF clones in mouse, rat for NRIP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NRIP1 (NM_003489)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRIP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRIP1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRIP1_HUMAN, P48552: Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon
    binding to ligand-bound NR3C1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0030054cell junction IDA--

    Find genes that share ontologies with NRIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NRIP1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Estrogen Pathway0.55
    2Transcription Ligand dependent activation of the ESR1 SP pathway
    Development Ligand dependent activation of the ESR1 AP 1 pathway0.37
    3Retinoic acid receptors-mediated signaling
    Retinoic acid receptors-mediated signaling
    4Ovarian Infertility Genes
    Ovarian Infertility Genes
    5FOXA1 transcription factor network
    FOXA1 transcription factor network

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NRIP1
        AHR Pathway
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for NRIP1
        Development Ligand-dependent activation of the ESR1/AP-1 pathway

    5 BioSystems Pathways for NRIP1
        Adipogenesis
    Ovarian Infertility Genes
    FOXA1 transcription factor network
    Retinoic acid receptors-mediated signaling
    Coregulation of Androgen receptor activity


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRIP1: 
              Estrogen Receptor Signaling in human mouse rat
              Prostate Cancer in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NRIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NRIP1 (P485521, 2, 3 ENSP000003272134) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT1Q998731, 2, 3EBI-746484,EBI-78738 MINT-3379810 MINT-3380537 MINT-3379909 MINT-3379739 I2D: score=3 
    CEP70Q8NHQ11, 2, 3, ENSP000002649824EBI-746484,EBI-739624 MINT-67759 I2D: score=5 STRING: ENSP00000264982
    RARAP102762, 3, ENSP000002540664MINT-5209920 I2D: score=6 STRING: ENSP00000254066
    CCDC85BQ158342, 3, ENSP000003116954MINT-68286 I2D: score=5 STRING: ENSP00000311695
    TEX11Q8IYF32, 3, ENSP000003409954MINT-67211 I2D: score=5 STRING: ENSP00000340995
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10364267
    GO:0001543ovarian follicle rupture IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0019915lipid storage IEA--

    Find genes that share ontologies with NRIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRIP1

    1 DrugBank Compound for NRIP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for NRIP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoid 68 27 11467847 (3), 14506269 (3), 19862326 (3), 15180561 (2) (see all 11)
    retinoic acid 61 105 17880687 (11), 11467847 (7), 14581481 (6), 15632153 (5) (see all 16)
    estrogen 57.6 36 15632153 (5), 7641693 (3), 10428779 (2), 10656848 (2) (see all 17)
    steroid 37.5 14 9280066 (1), 9774463 (1), 10659697 (1), 10428779 (1) (see all 10)
    4-hydroxytamoxifen 37.1 1 7641693 (1)
    geldanamycin 37 1 14668343 (1)
    estradiol 33.9 10 12554755 (2), 10656848 (2), 9774463 (1), 10725345 (1) (see all 5)
    tcdd 28.8 1 10428779 (1)
    leucine 5.95 1 9774688 (1)
    lipid 4.6 6 16923809 (1), 17391100 (1), 20205832 (1), 18794372 (1)



    Find genes that share compounds with NRIP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NRIP1 gene: 
    NM_003489.3  

    Unigene Cluster for NRIP1:

    Nuclear receptor interacting protein 1
    Hs.155017  [show with all ESTs]
    Unigene Representative Sequence: NM_003489
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400199 ENST00000400202 ENST00000411932 ENST00000318948(uc002yjx.2)

    miRNA
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    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-30a hsa-miR-208b hsa-miR-4325
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    GenScript: all cDNA clones in your preferred vector: NRIP1 (NM_003489)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NRIP1
      QuantiFast Probe-based Assays in human, mouse, rat NRIP1

    Additional mRNA sequence: 

    AK123818.1 AK289786.1 BC040361.1 X84373.1 

    2 DOTS entries:

    DT.417589  DT.40271499 

    Selected AceView cDNA sequences (see all 190):

    AI280217 AI536946 AW272717 AW299883 AI672268 BM141733 AI086104 BG392643 
    AI432495 BM802782 AA449089 AA775158 AA316125 AA855125 AI088568 AW664423 
    BG572709 CR623476 BI324954 BU620665 BU681671 AI859278 BM711435 BE082541 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTGTACA
    NRIP1 Expression
    About this image


    NRIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    NRIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.155017
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRIP1: 
              Estrogen Receptor Signaling in human mouse rat
              Prostate Cancer in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NRIP1
    OriGene qSTAR qPCR primer pairs in human, mouse for NRIP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRIP1
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    QuantiFast Probe-based Assays in human, mouse, rat NRIP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NRIP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrip11 , 5 nuclear receptor interacting protein 11, 5 83.12(n)1
    84.7(a)1
      16 (43.65 cM)5
    2689031  NM_173440.21  NP_775616.11 
     762874005 
    chicken
    (Gallus gallus)
    Aves NRIP11 nuclear receptor interacting protein 1 76.09(n)
    71.22(a)
      427966  XM_004938351.1  XP_004938408.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRIP16
    nuclear receptor interacting protein 1
    61(a)
    1 ↔ 1
    GL343230.1(2051237-2054749)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686652 hypothetical protein MGC68665 76.2(n)    BC063719.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nrip1b1 nuclear receptor interacting protein 1b 50.51(n)
    42.84(a)
      100001853  XM_005169195.1  XP_005169252.1 


    ENSEMBL Gene Tree for NRIP1 (if available)
    TreeFam Gene Tree for NRIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for NRIP1 gene
    2 SIMAP similar genes for NRIP1 using alignment to 2 protein entries:     NRIP1_HUMAN (see all proteins):
    NRIP1_var1    NRIP1_var2

    Find genes that share paralogs with NRIP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRIP1 (see all 2278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472737401,2
    --16333107(+) AACACA/GTGTAT 1 -- ds50010--------
    rs1863855741,2
    --16333136(+) TTGGAA/GAATTA 1 -- ds50010--------
    rs99783591,2
    H--16333209(+) CTGATA/GAAGTC 1 -- ds50014Minor allele frequency- G:0.00NS EA 394
    rs1922266011,2
    --16333249(+) ACATAC/TAGTCA 1 -- ds50010--------
    rs1407748131,2
    --16333252(+) TATAGC/TCAACA 1 -- ds50010--------
    rs21788951,2
    C,F,O,A,H--16333406(+) CTTGCT/CAGCCA 1 -- ds500116Minor allele frequency- C:0.16NA NS EA WA CSA 790
    rs1826340921,2
    --16333448(+) AAGGGA/CAAAAC 1 -- ds50010--------
    rs770399821,2
    F--16333496(+) TTTACG/ATTTAT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs787424741,2
    F--16333514(+) CTAAAA/TACCAG 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1430441171,2
    --16333604(+) TAAACA/GCTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NRIP1 (16333556 - 16437321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NRIP1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1174346CNV Deletion17803354
    esv2723187CNV Deletion23290073
    esv2664247CNV Deletion23128226
    esv1064466CNV Deletion17803354
    esv2723186CNV Deletion23290073
    esv1672496CNV Deletion17803354
    esv268950CNV Insertion20981092
    esv2565555CNV Insertion19546169
    nsv527611CNV Loss19592680
    dgv4680n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): NRIP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for NRIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602490    OMIM disorders: --

    1 disease for NRIP1:    
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    granuloma inguinale

    1 disease from the University of Copenhagen DISEASES database for NRIP1:
    Granuloma inguinale

    Find genes that share disorders with NRIP1           About GenesLikeMe

    9 Novoseek inferred disease relationships for NRIP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 44.5 10 17880687 (4), 11467847 (2), 15130509 (1), 14506269 (1)
    breast cancer 21.1 10 20410059 (2), 15632153 (2), 10828836 (1), 10612426 (1) (see all 8)
    necrosis 17.5 5 18269865 (1), 19232438 (1), 19910467 (1), 14668343 (1) (see all 5)
    down syndrome 0 2 9521594 (1)
    ovarian cancer 0 1 10828836 (1)
    infertility 0 1 16131398 (1)
    tumors 0 17 17880687 (5), 20410059 (2), 18269865 (1), 10589759 (1) (see all 8)
    alzheimers disease 0 1 9521594 (1)
    cancer 0 2 20410059 (1), 17880687 (1)

    Genetic Association Database (GAD): NRIP1
    Human Genome Epidemiology (HuGE) Navigator: NRIP1 (11 documents)

    Export disorders for NRIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRIP1 gene, integrated from 10 sources (see all 193):
    (articles sorted by number of sources associating them with NRIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Preliminary molecular genetic analysis of the receptor interacting protein 140 (RIP140) in women affected by endometriosis. (PubMed id 16131398)1, 2, 4, 9 Caballero V.... Ruiz A. (J. Exp. Clin. Assist. Reprod. 2005)
    2. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. (PubMed id 7641693)1, 2, 3, 9 Cavailles V.... Parker M.G. (EMBO J. 1995)
    3. Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140. (PubMed id 12773562)1, 2, 9 Tazawa H....Zilliacus J. (Mol. Cell. Biol. 2003)
    4. Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. (PubMed id 15060175)1, 2, 9 Castet A.... Cavailles V. (Nucleic Acids Res. 2004)
    5. Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids. (PubMed id 10364267)1, 2, 9 Subramaniam N.... Okret S. (J. Biol. Chem. 1999)
    6. Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome. (PubMed id 9521594)1, 3, 9 Katsanis N....Fisher E.M. (Hum. Genet. 1998)
    7. Receptor-interacting protein 140 binds c-Jun and inhibits estradiol- induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. (PubMed id 12554755)1, 2, 9 Teyssier C.... Chalbos D. (Mol. Endocrinol. 2003)
    8. Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140. (PubMed id 11266503)1, 2, 9 Zilliacus J....Gustafsson J.-A. (Mol. Endocrinol. 2001)
    9. Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. (PubMed id 14736873)1, 2, 9 Christian M.... Parker M.G. (J. Biol. Chem. 2004)
    10. Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP. (PubMed id 11509661)1, 2, 9 Vo N.... Goodman R.H. (Mol. Cell. Biol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8204 HGNC: 8001 AceView: NRIP1 Ensembl:ENSG00000180530 euGenes: HUgn8204
    ECgene: NRIP1 H-InvDB: NRIP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NRIP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRIP1 gene:
    Search GeneIP for patents involving NRIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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