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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NRIP1 Gene

protein-coding   GIFtS: 62
GCID: GC21M016333

nuclear receptor interacting protein 1
 Explore 27 diseases affiliated with
NRIP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NRIP1    

Aliases
for NRIP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Nuclear Receptor Interacting Protein 11 2
Nuclear Factor RIP1402 3 11
RIP1401 2 5
Receptor-Interacting Protein 1402 3
Nuclear Receptor-Interacting Protein 12
Receptor Interacting Protein 1402

External Ids:    HGNC: 80011   Entrez Gene: 82042   Ensembl: ENSG000001805307   OMIM: 6024905   UniProtKB: P485523   

Export aliases for NRIP1 gene to outside databases

Previous GC identifers: GC21M012997 GC21M015255 GC21M001716


Summaries
for NRIP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NRIP1:
Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the
hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates
transcriptional activity of the estrogen receptor. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NRIP1_HUMAN, P48552
Function: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates
transcriptional repression by nuclear hormone receptors

Gene Wiki entry for NRIP1


Genomic Views
for NRIP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NRIP1 gene promoter:
         ISGF-3   Spz1   NF-YA   Nkx2-5   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NRIP1 promoter sequence

   Search SABiosciences Chromatin IP Primers for NRIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11.2   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q11.2
Nature(405: 311-319) cytogenetic band:   21q11
NRIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRIP1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M016333:   GeneLoc Nature:405,311-319
Start:
 16,333,556 bp from pter       1,997,831 bp from centromere
End:
 16,437,321 bp from pter 2,005,069 bp from centromere
Size:
 103,766 bases 7,239 bases
Orientation:
 minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: X84373
genomic clones: P30P13 P270M7


Proteins
for NRIP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NRIP1_HUMAN, P48552 (See protein sequence)
Recommended Name: Nuclear receptor-interacting protein 1  
Size: 1158 amino acids; 126942 Da
Subunit: Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with
HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain);
the interaction results in promoting the repressor activity of NR2C1 (By similarity). Interacts with CTBP1, CTBP2,
ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and
YWHAH. Interacts with ZNF366
Subcellular location: Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding
to ligand-bound NR3C1
2 PDB 3D structures from and Proteopedia for NRIP1:
2GPO (3D)        2GPP (3D)    
Secondary accessions: Q8IWE8

Explore the universe of human proteins at neXtProt for NRIP1: NX_P48552

Post-translational modifications:

  • Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes
    • interaction with CTBP1. Phosphorylation enhances interaction with YWHAH1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48552

    • NRIP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003480.2  
    ENSEMBL proteins: 
     ENSP00000383060   ENSP00000383063   ENSP00000412114   ENSP00000327213  

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    Uscn Proteins for NRIP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex IEA--
    GO:0005634nucleus IDA12773562


    NRIP1 for ontologies           About GeneDecksing



    NRIP1 Antibody Products: 
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    ThermoFisher Antibody for NRIP1

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    Uscn ELISAs and CLIAs for NRIP1

    Protein Domains /
    Families
    for NRIP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NRIP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026649 NRIP1

    Graphical View of Domain Structure for InterPro Entry P48552

    ProtoNet protein and cluster: P48552

    UniProtKB/Swiss-Prot: NRIP1_HUMAN, P48552
    Domain: Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The
    C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homodimers and
    heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity).
    Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase
    (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms,
    depending on cell type. RD2 is dependent on CTBP binding


    Function
    for NRIP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NRIP1_HUMAN, P48552
    Function: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates
    transcriptional repression by nuclear hormone receptors

         Genatlas biochemistry entry for NRIP1:
    nuclear receptor interacting protein,widely expressed,modulating transcriptional activation by the estrogen receptor

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NRIP1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRIP1
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate NRIP1 (see all 97):
    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-30a hsa-miR-208b hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: NRIP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRIP1 (see all 4)
    OriGene shRNA RFP: NRIP1
    OriGene siRNA: NRIP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRIP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NRIP1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NRIP1 (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRIP1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NRIP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP1

    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS15572661
    GO:0003714transcription corepressor activity IDA10364267
    GO:0005102receptor binding ----
    GO:0005515protein binding IPI19401155
    GO:0030331estrogen receptor binding IPI7641693


    NRIP1 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nrip1):
     endocrine/exocrine gland  growth/size  reproductive system 

    NRIP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NRIP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Ligand-dependent activation of the ESR1/AP-1 pathway
    		Development_Ligand-dependent activation of the ESR1/AP-1 pathway1.00
    		Development Ligand-dependent activation of the ESR1/AP-1 pathway1.00
    2Adipogenesis
    		Adipogenesis1.00
    3Ovarian Infertility Genes
    		Ovarian Infertility Genes1.00
    4Coregulation of Androgen receptor activity
    		Coregulation of Androgen receptor activity1.00
    5Retinoic acid receptors-mediated signaling
    		Retinoic acid receptors-mediated signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NRIP1
        Development Ligand-dependent activation of the ESR1/AP-1 pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NRIP1
        AHR Pathway
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for NRIP1
        Development Ligand-dependent activation of the ESR1/AP-1 pathway

    5 BioSystems Pathways for NRIP1 
        Adipogenesis
    Ovarian Infertility Genes
    FOXA1 transcription factor network
    Retinoic acid receptors-mediated signaling
    Coregulation of Androgen receptor activity



    NRIP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NRIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/113 Interacting proteins for NRIP1 (P485521, 2, 3 ENSP000003272134) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP70Q8NHQ11, 2, 3, ENSP000002649824EBI-746484,EBI-739624 MINT-67759 I2D: score=5 STRING: ENSP00000264982
    PRMT1Q998732, 3MINT-3379810 MINT-3380537 MINT-3379909 MINT-3379739 I2D: score=3 
    RARAP102762, 3, ENSP000002540664MINT-5209920 I2D: score=6 STRING: ENSP00000254066
    CCDC85BQ158342, 3, ENSP000003116954MINT-68286 I2D: score=5 STRING: ENSP00000311695
    TEX11Q8IYF32, 3, ENSP000003409954MINT-67211 I2D: score=5 STRING: ENSP00000340995
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10364267
    GO:0001543ovarian follicle rupture IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0019915lipid storage IEA--


    NRIP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NRIP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NRIP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NRIP1

    1 DrugBank Compound for NRIP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE-- --target--10592235

    10/13 Novoseek chemical compound relationships for NRIP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoid 68 27 11467847 (3), 14506269 (3), 19862326 (3), 15180561 (2) (see all 11)
    retinoic acid 61 105 17880687 (11), 11467847 (7), 14581481 (6), 15632153 (5) (see all 16)
    estrogen 57.6 36 15632153 (5), 7641693 (3), 10428779 (2), 10656848 (2) (see all 17)
    steroid 37.5 14 9280066 (1), 9774463 (1), 10659697 (1), 10428779 (1) (see all 10)
    4-hydroxytamoxifen 37.1 1 7641693 (1)
    geldanamycin 37 1 14668343 (1)
    estradiol 33.9 10 12554755 (2), 10656848 (2), 9774463 (1), 10725345 (1) (see all 5)
    tcdd 28.8 1 10428779 (1)
    leucine 5.95 1 9774688 (1)
    lipid 4.6 6 16923809 (1), 17391100 (1), 20205832 (1), 18794372 (1)

    Search CenterWatch for drugs/clinical trials and news about NRIP1 

    Transcripts
    for NRIP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NRIP1 gene: 
    NM_003489.3  

    Unigene Cluster for NRIP1:

    Nuclear receptor interacting protein 1
    Hs.155017  [show with all ESTs]
    Unigene Representative Sequence: NM_003489
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400199 ENST00000400202 ENST00000411932 ENST00000318948(uc002yjx.2)


    miRNA
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    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate NRIP1 (see all 97):
    hsa-miR-411* hsa-miR-607 hsa-miR-3607-3p hsa-miR-4272 hsa-miR-30d hsa-miR-30a hsa-miR-208b hsa-miR-4325
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK123818.1 AK289786.1 BC040361.1 X84373.1 

    2 DOTS entries:

    DT.417589  DT.40271499 

    24/190 AceView cDNA sequences (see all 190):

    CK819825 BU681671 AI672268 BP336927 BI335848 AA855125 D82512 BM711435 
    BM141733 AI432495 AA775158 AA316125 AW272717 BM802782 AI536946 BU620665 
    CR623476 BM724660 BG392643 AA449089 BC040361 BQ221955 AI086104 AW271632 

    GeneLoc Exon Structure


    Expression
    for NRIP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NRIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAACTGTACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NRIP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See NRIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NRIP1

    SOURCE GeneReport for Unigene cluster: Hs.155017
        SABiosciences Expression via Pathway-Focused PCR Arrays including NRIP1: 
              Estrogen Receptor Signaling in human mouse rat
              Prostate Cancer in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRIP1

    Orthologs
    for NRIP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NRIP1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nrip11 , 5 nuclear receptor interacting protein 11, 5 83.15(n)1
    84.7(a)1    		   16 (43.65 cM)5
    2689031  NM_173440.21  NP_775616.11 
     762874005 
    chicken
    (Gallus gallus)    		 Aves NRIP11 nuclear receptor interacting protein 1 76.09(n)
    71.22(a)    		   427966  XM_425538.3  XP_425538.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NRIP16
    		 --
    		 61(a)
    		 1 ↔ 1
    		 GL343230.1(2051237-2054749)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686652 hypothetical protein MGC68665 76.2(n)    BC063719.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7964071 RIP140-A 49.33(n)
    40.12(a)    		   796407  XM_001336701.1  XP_001336737.1 


    ENSEMBL Gene Tree for NRIP1 (if available)
    TreeFam Gene Tree for NRIP1 (if available) 

    Paralogs
    for NRIP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NRIP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1939 NCBI SNPs in NRIP1 are shown (see all 1939)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1472737401,2
    		--16333107(+) AACACA/GTGTAT 1 -- ds50010--------
    rs1863855741,2
    		--16333136(+) TTGGAA/GAATTA 1 -- ds50010--------
    rs99783591,2
    		H--16333209(+) CTGATA/GAAGTC 1 -- ds50014Minor allele frequency- G:0.00NS EA 394
    rs1922266011,2
    		--16333249(+) ACATAC/TAGTCA 1 -- ds50010--------
    rs1407748131,2
    		--16333252(+) TATAGC/TCAACA 1 -- ds50010--------
    rs21788951,2
    		C,F,O,A,H,--16333406(+) CTTGCT/CAGCCA 1 -- ds500116Minor allele frequency- C:0.16NA NS EA WA CSA 790
    rs1826340921,2
    		--16333448(+) AAGGGA/CAAAAC 1 -- ds50010--------
    rs770399821,2
    		F,--16333496(+) TTTACG/ATTTAT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs787424741,2
    		F,--16333514(+) CTAAAA/TACCAG 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1430441171,2
    		--16333604(+) TAAACA/GCTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NRIP1 (16333556 - 16437321 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for NRIP1
         2 CNVs: 67745 50732
         3 Indels: 103039 26928 26927
    Human Gene Mutation Database (HGMD): NRIP1

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    Disorders / Diseases
    for NRIP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NRIP1 for disorders           About GeneDecksing

    OMIM gene information: 602490    OMIM disorders: --

    20/27 diseases for NRIP1 (see all 27):    About MalaCards
    granuloma inguinale    polycystic ovary syndrome    systemic lupus erythematosus    lupus erythematosus
    male infertility    morbid obesity    sporadic breast cancer    down syndrome
    epithelial ovarian cancer    ovarian cancer    infertility    embryonal carcinoma
    breast cancer    migraine    osteoporosis    obesity
    endometriosis    prostate cancer    glioblastoma    ataxia

    1 disease from the University of Copenhagen DISEASES database for NRIP1:
    Granuloma inguinale

    9 Novoseek disease relationships for NRIP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 44.5 10 17880687 (4), 11467847 (2), 15130509 (1), 14506269 (1)
    breast cancer 21.1 10 20410059 (2), 15632153 (2), 10828836 (1), 10612426 (1) (see all 8)
    necrosis 17.5 5 18269865 (1), 19232438 (1), 19910467 (1), 14668343 (1) (see all 5)
    down syndrome 0 2 9521594 (1)
    ovarian cancer 0 1 10828836 (1)
    infertility 0 1 16131398 (1)
    tumors 0 17 17880687 (5), 20410059 (2), 18269865 (1), 10589759 (1) (see all 8)
    alzheimers disease 0 1 9521594 (1)
    cancer 0 2 20410059 (1), 17880687 (1)

    Genetic Association Database (GAD): NRIP1
    Human Genome Epidemiology (HuGE) Navigator: NRIP1 (11 documents)

    Export disorders for NRIP1 gene to outside databases

    Publications
    for NRIP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NRIP1 gene, integrated from 9 sources (see all 181):
    (articles sorted by number of sources associating them with NRIP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Preliminary molecular genetic analysis of the receptor interacting protein 140 (RIP140) in women affected by endometriosis. (PubMed id 16131398)1, 2, 4, 9 Caballero V.... Ruiz A. (2005)
    2. Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. (PubMed id 7641693)1, 2, 3, 9 Cavailles V.... Parker M.G. (1995)
    3. Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140. (PubMed id 12773562)1, 2, 9 Tazawa H....Zilliacus J. (2003)
    4. Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition. (PubMed id 15060175)1, 2, 9 Castet A.... Cavailles V. (2004)
    5. Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids. (PubMed id 10364267)1, 2, 9 Subramaniam N.... Okret S. (1999)
    6. Localisation of receptor interacting protein 140 (RIP 140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome. (PubMed id 9521594)1, 3, 9 Katsanis N....Fisher E.M. (1998)
    7. Receptor-interacting protein 140 binds c-Jun and inhibits estradiol- induced activator protein-1 activity by reversing glucocorticoid receptor-interacting protein 1 effect. (PubMed id 12554755)1, 2, 9 Teyssier C.... Chalbos D. (2003)
    8. Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140. (PubMed id 11266503)1, 2, 9 Zilliacus J....Gustafsson J.-A. (2001)
    9. Characterization of four autonomous repression domains in the corepressor receptor interacting protein 140. (PubMed id 14736873)1, 2, 9 Christian M.... Parker M.G. (2004)
    10. Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP. (PubMed id 11509661)1, 2, 9 Vo N.... Goodman R.H. (2001)

    External Searches for NRIP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    Genome Databases showing NRIP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8204 HGNC: 8001 AceView: NRIP1 Ensembl:ENSG00000180530 euGenes: HUgn8204
    ECgene: NRIP1 H-InvDB: NRIP1

    Other Databases showing NRIP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NRIP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NRIP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NRIP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NRIP1 gene:
    Search GeneIP for patents involving NRIP1

    GeneCards and IP:
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