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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NRGN Gene

protein-coding   GIFtS: 59
GCID: GC11P124609

Neurogranin (Protein Kinase C Substrate, RC3)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurogranin (Protein Kinase C Substrate, RC3)1 2     neurogranin2
RC32 3     ng2
Calmodulin-Binding Protein2     Protein Kinase C Substrate2
hng2     Ng3

External Ids:    HGNC: 80001   Entrez Gene: 49002   Ensembl: ENSG000001541467   OMIM: 6023505   UniProtKB: Q926863   

Export aliases for NRGN gene to outside databases

Previous GC identifers: GC11P126610 GC11P126122 GC11P124643 GC11P124147 GC11P124114 GC11P120552


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NRGN Gene:
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a
postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains
four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated
sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control
of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during
development as well as in adult subjects. (provided by RefSeq, Jul 2008)

GeneCards Summary for NRGN Gene: 
NRGN (neurogranin (protein kinase C substrate, RC3)) is a protein-coding gene. Diseases associated with NRGN include jacobsen syndrome, and paraneoplastic cerebellar degeneration. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot: NEUG_HUMAN, Q92686
Function: Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic
development and remodeling. Binds to calmodulin in the absence of calcium (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NRGN gene promoter:
         Max1   Spz1   LCR-F1   CREB   S8   deltaCREB   LyF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRGN promoter sequence
   Search SABiosciences Chromatin IP Primers for NRGN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24

NRGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRGN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P124609:  view genomic region     (about GC identifiers)

Start:
124,609,829 bp from pter      End:
124,617,869 bp from pter
Size:
8,041 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEUG_HUMAN, Q92686 (See protein sequence)
Recommended Name: Neurogranin  
Size: 78 amino acids; 7618 Da

Explore the universe of human proteins at neXtProt for NRGN: NX_Q92686

Explore proteomics data for NRGN at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-36 by PHK (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92686

  • NRGN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NRGN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001119653.1  NP_006167.1  

    ENSEMBL proteins: 
     ENSP00000399591   ENSP00000432255   ENSP00000284292  

    Human Recombinant Protein Products for NRGN: 
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    Novus Biologicals NRGN Protein
    Novus Biologicals NRGN Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NRGN 


    NRGN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NRGN
    R&D Systems Antibodies for NRGN (Neurogranin)
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    LSBio Antibodies in human, mouse, rat for NRGN 

    Assay Products for NRGN: 
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    Cloud-Clone Corp. ELISAs for NRGN 
    Cloud-Clone Corp. CLIAs for NRGN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q92686

    ProtoNet protein and cluster: Q92686

    UniProtKB/Swiss-Prot: NEUG_HUMAN, Q92686
    Similarity: Belongs to the neurogranin family
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 IQ domain


    NRGN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUG_HUMAN, Q92686
    Function: Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic
    development and remodeling. Binds to calmodulin in the absence of calcium (By similarity)

         Genatlas biochemistry entry for NRGN:
    neurogranin,rat Ng/RC3 homolog gene encoding a brain-specific protein expressed in telencephalic neurons,target of
    thyroid hormone in brain (thyroid hormone-responsive element in the first intron)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
         
    NRGN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NRGN:
     Increased cell number in G1, a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nrgn):
     behavior/neurological  nervous system 

    NRGN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NRGN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NRGN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRGN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NRGN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRGN
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate NRGN (see all 28):
    hsa-miR-596 hsa-miR-148b* hsa-miR-330-5p hsa-miR-658 hsa-miR-1908 hsa-miR-650 hsa-miR-877* hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidNRGN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): NRGN (NM_001126181)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of NRGN 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRGN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NRGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for NRGN (Q926863 ENSP000002842924) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    PRKCBP057713, ENSP000003053554I2D: score=2 STRING: ENSP00000305355
    PRKCGP051293, ENSP000002634314I2D: score=2 STRING: ENSP00000263431
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10075657
    GO:0007399nervous system development TAS10075657

    NRGN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NRGN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NRGN (NEUG)

    1 HMDB Compound for NRGN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/16 Novoseek inferred chemical compound relationships for NRGN gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 69.1 1 8519597 (1)
    aroclor 1254 50.4 2 10614638 (2)
    phosphatidylserine 47.3 2 7533539 (1), 7840634 (1)
    calcium 40.7 32 7840634 (3), 7896819 (3), 15469893 (2), 16797925 (2) (see all 14)
    bisphenol a 33.3 3 15498886 (2), 17412439 (1)
    nmda 27 4 9138717 (1), 17140601 (1), 10088994 (1)
    phosphatidylinositol 24.2 5 8519597 (2)
    phosphatidylcholine 18.5 5 8519597 (2)
    phospholipid 17.4 2 8611023 (1), 1826685 (1)
    phosphoinositide 13.9 1 8611023 (1)

    Search CenterWatch for drugs/clinical trials and news about NRGN / NEUG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NRGN gene (2 alternative transcripts): 
    NM_001126181.1  NM_006176.2  

    Unigene Cluster for NRGN:

    Neurogranin (protein kinase C substrate, RC3)
    Hs.524116  [show with all ESTs]
    Unigene Representative Sequence: BM548510
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412681(uc001qar.2) ENST00000526916 ENST00000284292(uc001qaq.2)


    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate NRGN (see all 28):
    hsa-miR-596 hsa-miR-148b* hsa-miR-330-5p hsa-miR-658 hsa-miR-1908 hsa-miR-650 hsa-miR-877* hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidNRGN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NRGN
    Clone
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    OriGene ORF clones in mouse, rat for NRGN
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRGN
    Sirion Biotech Customized lentivirus for stable overexpression of NRGN 
                         Customized lentivirus expression plasmids for stable overexpression of NRGN 
    Primer
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    OriGene qPCR primer pairs and template standards for NRGN
    OriGene qSTAR qPCR primer pairs in human, mouse for NRGN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NRGN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NRGN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NRGN

    Additional mRNA sequence: 

    BC002835.2 BT007325.1 U89165.1 Y09689.1 

    13 DOTS entries:

    DT.452566  DT.92429839  DT.95284674  DT.206890  DT.91716298  DT.92042928  DT.92414920  DT.120717876 
    DT.75102947  DT.86843104  DT.95284671  DT.100754886  DT.120717885 

    24/157 AceView cDNA sequences (see all 157):

    AI383972 BX091785 AI498929 CA422673 AI203843 AA354640 BM923818 CA445014 
    BQ028841 BP350470 AA777530 C02047 H22488 BM701366 BC002835 BM985307 
    AW590389 Y09689 F01422 CA447471 BT007325 AI125174 AI885287 H41184 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NRGN expression in normal human tissues (normalized intensities)      NRGN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGTGCT
    NRGN Expression
    About this image


    NRGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Thalamus
             Globus Pallidus   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See NRGN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NRGN

    SOURCE GeneReport for Unigene cluster: Hs.524116

    UniProtKB/Swiss-Prot: NEUG_HUMAN, Q92686
    Tissue specificity: In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and
    basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NRGN gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrgn1 , 5 neurogranin1, 5 91.45(n)1
    96.15(a)1
      9 (20.78 cM)5
    640111  NM_022029.21  NP_071312.11 
     375444925 
    chicken
    (Gallus gallus)
    Aves NRGN6
    neurogranin (protein kinase C substrate, RC3)
    67(a)
    1 ↔ 1
    24(294677-296798)
    lizard
    (Anolis carolinensis)
    Reptilia NRGN6
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343322.1(80478-80666)
    zebrafish
    (Danio rerio)
    Actinopterygii nrgna6
    neurogranin (protein kinase C substrate, RC3) a
    55(a)
    1 ↔ 1
    5(59838779-59849270)


    ENSEMBL Gene Tree for NRGN (if available)
    TreeFam Gene Tree for NRGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NRGN gene
    1 SIMAP similar gene for NRGN using alignment to 1 protein entry:     NEUG_HUMAN:
    GAP43

    NRGN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 SNPs in NRGN are shown (see all 143)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128823001,2
    C,F--124607897(+) GAAGGG/ACTGTG 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs718834471,2
    C--124607922(+) TGGTG-/GGGGGG 2 -- us2k10--------
    rs1815764441,2
    --124607923(+) TTGGTC/GGGGGG 2 -- us2k10--------
    rs2015004641,2
    C--124607930(+) GGGGG-/G/GG  
            
    TGTTG
    2 -- us2k10--------
    rs1479440321,2
    --124608046(+) TCACCA/GAATCC 2 -- us2k10--------
    rs1418675521,2
    --124608219(+) CAAGGA/GCCTGA 2 -- us2k10--------
    rs1455179981,2
    --124608248(+) CACTTA/GGAGGA 2 -- us2k10--------
    rs6551041,2
    C,F,A,H--124608304(-) TGTAAC/AAAAAA 2 -- us2k116Minor allele frequency- A:0.02MN NA WA CSA EA 699
    rs1841847821,2
    --124608336(+) TGCTGC/GGAGAG 2 -- us2k10--------
    rs1163486551,2
    C,F--124608486(+) CGGGCC/GCAAAC 2 -- us2k11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for NRGN (124609829 - 124617869 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NRGN:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1321n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): NRGN
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NRGN
    DNA2.0 Custom Variant and Variant Library Synthesis for NRGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602350    OMIM disorders: --

    17 diseases for NRGN:    About MalaCards
    jacobsen syndrome    paraneoplastic cerebellar degeneration    cerebellar degeneration    hypothyroidism
    congenital hypothyroidism    schizophrenia    thyroiditis    bipolar disorder
    lateral sclerosis    amyotrophic lateral sclerosis    dementia    neuronitis
    glioblastoma    alzheimer's disease    cerebritis    prostatitis
    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for NRGN:
    Schizophrenia     Hypothyroidism

    NRGN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for NRGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypothyroidism 37.2 2 12889141 (1), 7539519 (1)
    schizophrenia 14.8 8 17140601 (4), 19571808 (1)
    neurological disorders 0 1 2285268 (1)

    Genetic Association Database (GAD): NRGN
    Human Genome Epidemiology (HuGE) Navigator: NRGN (4 documents)

    Export disorders for NRGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NRGN gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with NRGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN). (PubMed id 9143500)1, 2, 3, 9 Martinez de Arrieta C.... Coloma A. (1997)
    2. Association of the gene encoding neurogranin with schizophrenia in males. (PubMed id 17140601)1, 4, 9 Ruano D....Palha J.A. (2008)
    3. Structure and chromosomal localization of human neurogranin gene. (PubMed id 9499372)1, 2, 9 Mertsalov I.B.... Tsetlin V.I. (1997)
    4. Cloning cDNA for human neurogranin. (PubMed id 8929222)1, 2, 9 Mertsalov I.B.... Tsetlin V.I. (1996)
    5. Common variants conferring risk of schizophrenia. (PubMed id 19571808)1, 4, 9 Stefansson H....Collier D.A. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. [Neurogranin: a brain-specific protein] (PubMed id 12889141)1, 9 Li H.Y....Lu G.W. (2003)
    8. Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor. (PubMed id 12808095)1, 9 Devireddy L.R. and Green M.R. (2003)
    9. Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia. (PubMed id 9329454)2, 9 Chang J.W.... Watson J.B. (1997)
    10. The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron. (PubMed id 9886843)1, 9 Martinez de Arrieta C....Bernal J. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4900 HGNC: 8000 AceView: NRGN Ensembl:ENSG00000154146 euGenes: HUgn4900
    ECgene: NRGN H-InvDB: NRGN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NRGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NRGN gene:
    Search GeneIP for patents involving NRGN

    GeneCards and IP:
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