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Aliases for NRGN Gene

Aliases for NRGN Gene

  • Neurogranin (Protein Kinase C Substrate, RC3) 2 3
  • RC3 3 4
  • Ng 3 4
  • Calmodulin-Binding Protein 3
  • Protein Kinase C Substrate 3
  • Hng 3

External Ids for NRGN Gene

Previous GeneCards Identifiers for NRGN Gene

  • GC11P126610
  • GC11P126122
  • GC11P124643
  • GC11P124147
  • GC11P124114
  • GC11P124609
  • GC11P120552

Summaries for NRGN Gene

Entrez Gene Summary for NRGN Gene

  • Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRGN Gene

NRGN (Neurogranin (Protein Kinase C Substrate, RC3)) is a Protein Coding gene. Diseases associated with NRGN include polyendocrine-polyneuropathy syndrome and jacobsen syndrome. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for NRGN Gene

  • Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRGN Gene

Genomics for NRGN Gene

Regulatory Elements for NRGN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NRGN Gene

Chromosome:
11
Start:
124,739,846 bp from pter
End:
124,747,210 bp from pter
Size:
7,365 bases
Orientation:
Plus strand

Genomic View for NRGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRGN Gene

Proteins for NRGN Gene

  • Protein details for NRGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92686-NEUG_HUMAN
    Recommended name:
    Neurogranin
    Protein Accession:
    Q92686

    Protein attributes for NRGN Gene

    Size:
    78 amino acids
    Molecular mass:
    7618 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRGN Gene

Proteomics data for NRGN Gene at MOPED

Post-translational modifications for NRGN Gene

  • Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRGN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NRGN Gene

Domains & Families for NRGN Gene

Protein Domains for NRGN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92686

UniProtKB/Swiss-Prot:

NEUG_HUMAN :
  • Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.
  • Belongs to the neurogranin family.
Domain:
  • Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.
  • Contains 1 collagen-like domain.
  • Contains 1 IQ domain.
Family:
  • Belongs to the neurogranin family.
genes like me logo Genes that share domains with NRGN: view

No data available for Gene Families for NRGN Gene

Function for NRGN Gene

Molecular function for NRGN Gene

GENATLAS Biochemistry:
neurogranin,rat Ng/RC3 homolog gene encoding a brain-specific protein expressed in telencephalic neurons,target of thyroid hormone in brain (thyroid hormone-responsive element in the first intron)
UniProtKB/Swiss-Prot Function:
Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).

Gene Ontology (GO) - Molecular Function for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA --
GO:0070300 phosphatidic acid binding IEA --
genes like me logo Genes that share ontologies with NRGN: view

Phenotypes for NRGN Gene

genes like me logo Genes that share phenotypes with NRGN: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRGN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NRGN Gene

Localization for NRGN Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRGN Gene COMPARTMENTS Subcellular localization image for NRGN gene
Compartment Confidence
cytoskeleton 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0012510 trans-Golgi network transport vesicle membrane IEA --
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with NRGN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NRGN Gene

Pathways & Interactions for NRGN Gene

SuperPathways for NRGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10075657
GO:0007399 nervous system development TAS 10075657
GO:0008306 associative learning IEA --
GO:0021537 telencephalon development IEA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with NRGN: view

No data available for Pathways by source and SIGNOR curated interactions for NRGN Gene

Drugs & Compounds for NRGN Gene

(8) Drugs for NRGN Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Levothyroxine Approved Pharma 0
Nitric Oxide Approved Pharma 540
Phosphatidylserine Approved Nutra 0
Bisphenol A Experimental Pharma 12

(8) Additional Compounds for NRGN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aroclor 1254
glutamate
PHOSPHATIDYLCHOLINE
Phosphatidylinositol
phosphoinositide
genes like me logo Genes that share compounds with NRGN: view

Transcripts for NRGN Gene

mRNA/cDNA for NRGN Gene

Unigene Clusters for NRGN Gene

Neurogranin (protein kinase C substrate, RC3):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRGN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRGN Gene

No ASD Table

Relevant External Links for NRGN Gene

GeneLoc Exon Structure for
NRGN
ECgene alternative splicing isoforms for
NRGN

Expression for NRGN Gene

mRNA expression in normal human tissues for NRGN Gene

mRNA differential expression in normal tissues according to GTEx for NRGN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.5), Brain - Cortex (x8.0), Brain - Frontal Cortex (BA9) (x7.5), Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Caudate (basal ganglia) (x5.1), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for NRGN Gene

This gene is overexpressed in Platelet (19.9), Brain (16.0), Frontal cortex (8.0), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRGN Gene



SOURCE GeneReport for Unigene cluster for NRGN Gene Hs.524116

mRNA Expression by UniProt/SwissProt for NRGN Gene

Q92686-NEUG_HUMAN
Tissue specificity: In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.
genes like me logo Genes that share expression patterns with NRGN: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for NRGN Gene

Orthologs for NRGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRGN 35
  • 100 (n)
  • 100 (a)
NRGN 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrgn 16
Nrgn 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRGN 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRGN 36
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRGN 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRGN 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRGN 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nrgna 36
  • 60 (a)
OneToOne
Species with no ortholog for NRGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRGN Gene

ENSEMBL:
Gene Tree for NRGN (if available)
TreeFam:
Gene Tree for NRGN (if available)

Paralogs for NRGN Gene

(1) SIMAP similar genes for NRGN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NRGN: view

No data available for Paralogs for NRGN Gene

Variants for NRGN Gene

Sequence variations from dbSNP and Humsavar for NRGN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs655104 -- 124,738,408(-) TGTAA(A/C)AAAAA upstream-variant-2KB
rs781491609 -- 124,738,610(+) GAAAG(A/G)AAGCA upstream-variant-2KB
rs778812086 -- 124,738,541(+) GACTC(A/T)GGCAT upstream-variant-2KB
rs773749710 -- 124,738,844(+) TTTTG(G/T)ACCCT upstream-variant-2KB
rs773416985 -- 124,738,163(+) AATTC(C/T)TCAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRGN Gene

Variant ID Type Subtype PubMed ID
dgv1321n71 CNV Loss 21882294

Variation tolerance for NRGN Gene

Residual Variation Intolerance Score: 58.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRGN Gene

HapMap Linkage Disequilibrium report
NRGN
Human Gene Mutation Database (HGMD)
NRGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRGN Gene

Disorders for NRGN Gene

MalaCards: The human disease database

(6) MalaCards diseases for NRGN Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
polyendocrine-polyneuropathy syndrome
  • pepns
jacobsen syndrome
  • chromosome 11q deletion
paraneoplastic cerebellar degeneration
hypothyroidism
  • thyroid deficiency
alzheimer disease
  • alzheimer disease, late-onset
- elite association
Search NRGN in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRGN

Genetic Association Database (GAD)
NRGN
Human Genome Epidemiology (HuGE) Navigator
NRGN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRGN
genes like me logo Genes that share disorders with NRGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRGN Gene

Publications for NRGN Gene

  1. Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN). (PMID: 9143500) Martinez de Arrieta C. … Coloma A. (Genomics 1997) 2 23 67
  2. Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma. (PMID: 20419098) Lin B. … Foltz G. (PLoS ONE 2010) 23 67
  3. Neurogranin enhances synaptic strength through its interaction with calmodulin. (PMID: 19713936) Zhong L. … Gerges N.Z. (EMBO J. 2009) 23 67
  4. Long-term potentiation: two pathways meet at neurogranin. (PMID: 19809472) Hayashi Y. (EMBO J. 2009) 23 67
  5. Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. (PMID: 18789340) Szabo S.T. … Du J. (Neuropharmacology 2009) 23 67

Products for NRGN Gene

Sources for NRGN Gene

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