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Aliases for NRGN Gene

Aliases for NRGN Gene

  • Neurogranin (Protein Kinase C Substrate, RC3) 2 3
  • RC3 3 4
  • Ng 3 4
  • Calmodulin-Binding Protein 3
  • Protein Kinase C Substrate 3
  • Neurogranin 3
  • Hng 3

External Ids for NRGN Gene

Previous GeneCards Identifiers for NRGN Gene

  • GC11P126610
  • GC11P126122
  • GC11P124643
  • GC11P124147
  • GC11P124114
  • GC11P124609
  • GC11P120552

Summaries for NRGN Gene

Entrez Gene Summary for NRGN Gene

  • Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRGN Gene

NRGN (Neurogranin (Protein Kinase C Substrate, RC3)) is a Protein Coding gene. Diseases associated with NRGN include jacobsen syndrome and paraneoplastic cerebellar degeneration. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for NRGN Gene

  • Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRGN Gene

Genomics for NRGN Gene

Regulatory Elements for NRGN Gene

Genomic Location for NRGN Gene

124,739,846 bp from pter
124,747,210 bp from pter
7,365 bases
Plus strand

Genomic View for NRGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRGN Gene

Proteins for NRGN Gene

  • Protein details for NRGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for NRGN Gene

    78 amino acids
    Molecular mass:
    7618 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NRGN Gene

Proteomics data for NRGN Gene at MOPED

Post-translational modifications for NRGN Gene

  • Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRGN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRGN Gene

Domains for NRGN Gene

Protein Domains for NRGN Gene


Suggested Antigen Peptide Sequences for NRGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92686
  • Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.
  • Contains 1 collagen-like domain.
  • Contains 1 IQ domain.
  • Belongs to the neurogranin family.
genes like me logo Genes that share domains with NRGN: view

No data available for Gene Families for NRGN Gene

Function for NRGN Gene

Molecular function for NRGN Gene

GENATLAS Biochemistry: neurogranin,rat Ng/RC3 homolog gene encoding a brain-specific protein expressed in telencephalic neurons,target of thyroid hormone in brain (thyroid hormone-responsive element in the first intron)
UniProtKB/Swiss-Prot Function: Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).

Gene Ontology (GO) - Molecular Function for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with NRGN: view

Phenotypes for NRGN Gene

MGI mutant phenotypes for NRGN:
inferred from 2 alleles
GenomeRNAi human phenotypes for NRGN:
genes like me logo Genes that share phenotypes with NRGN: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NRGN Gene

Localization for NRGN Gene

Subcellular locations from

Jensen Localization Image for NRGN Gene COMPARTMENTS Subcellular localization image for NRGN gene
Compartment Confidence
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with NRGN: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NRGN Gene

Pathways for NRGN Gene

SuperPathways for NRGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10075657
GO:0007399 nervous system development TAS 10075657
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with NRGN: view

No data available for Pathways by source for NRGN Gene

Compounds for NRGN Gene

(1) HMDB Compounds for NRGN Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(16) Novoseek inferred chemical compound relationships for NRGN Gene

Compound -log(P) Hits PubMed IDs
pkcs 69.1 1
aroclor 1254 50.4 2
phosphatidylserine 47.3 2
calcium 40.7 22
bisphenol a 33.3 3
genes like me logo Genes that share compounds with NRGN: view

Transcripts for NRGN Gene

mRNA/cDNA for NRGN Gene

Unigene Clusters for NRGN Gene

Neurogranin (protein kinase C substrate, RC3):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRGN Gene

No ASD Table

Relevant External Links for NRGN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRGN Gene

mRNA expression in normal human tissues for NRGN Gene

mRNA differential expression in normal tissues according to GTEx for NRGN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (8.5), Brain - Cortex (8.0), Brain - Frontal Cortex (BA9) (7.5), Brain - Anterior cingulate cortex (BA24) (5.7), Brain - Caudate (basal ganglia) (5.1), and Brain - Amygdala (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRGN Gene

SOURCE GeneReport for Unigene cluster for NRGN Gene Hs.524116

mRNA Expression by UniProt/SwissProt for NRGN Gene

Tissue specificity: In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.
genes like me logo Genes that share expressions with NRGN: view

Orthologs for NRGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRGN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NRGN 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia NRGN 36
  • 97 (a)
(Canis familiaris)
Mammalia NRGN 36
  • 41 (a)
(Mus musculus)
Mammalia Nrgn 16
Nrgn 36
  • 96 (a)
(Monodelphis domestica)
Mammalia NRGN 36
  • 95 (a)
(Gallus gallus)
Aves NRGN 36
  • 72 (a)
(Anolis carolinensis)
Reptilia NRGN 36
  • 68 (a)
(Danio rerio)
Actinopterygii nrgna 36
  • 60 (a)
Species with no ortholog for NRGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRGN Gene

Gene Tree for NRGN (if available)
Gene Tree for NRGN (if available)

Paralogs for NRGN Gene

Selected SIMAP similar genes for NRGN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NRGN: view

No data available for Paralogs for NRGN Gene

Variants for NRGN Gene

Sequence variations from dbSNP and Humsavar for NRGN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs655104 -- 124,738,408(-) TGTAA(A/C)AAAAA upstream-variant-2KB
rs1128993 -- 124,740,034(+) CCCCA(C/T)CCCCG utr-variant-5-prime
rs11399333 -- 124,740,115(+) GGCCC(-/G)GGGGG intron-variant
rs12278912 -- 124,742,263(+) CTCTT(A/G)GGGGC intron-variant
rs34046382 -- 124,741,885(+) CAGGG(-/G)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRGN Gene

Variant ID Type Subtype PubMed ID
dgv1321n71 CNV Loss 21882294

Relevant External Links for NRGN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRGN Gene

Disorders for NRGN Gene

(2) University of Copenhagen DISEASES for NRGN Gene

(3) Novoseek inferred disease relationships for NRGN Gene

Disease -log(P) Hits PubMed IDs
hypothyroidism 37.2 2
schizophrenia 14.8 5
neurological disorders 0 1

Relevant External Links for NRGN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NRGN: view

No data available for UniProtKB/Swiss-Prot for NRGN Gene

Publications for NRGN Gene

  1. Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN). (PMID: 9143500) Martinez de Arrieta C. … Coloma A. (Genomics 1997) 2 3 4 23
  2. Cloning cDNA for human neurogranin. (PMID: 8929222) Mertsalov I.B. … Tsetlin V.I. (Bioorg. Khim. 1996) 3 4 23
  3. Association of the gene encoding neurogranin with schizophrenia in males. (PMID: 17140601) Ruano D. … Palha J.A. (J Psychiatr Res 2008) 3 23 48
  4. Structure and chromosomal localization of human neurogranin gene. (PMID: 9499372) Mertsalov I.B. … Tsetlin V.I. (Bioorg. Khim. 1997) 3 4 23
  5. Common variants conferring risk of schizophrenia. (PMID: 19571808) Stefansson H. … Collier D.A. (Nature 2009) 3 23 48

Products for NRGN Gene

Sources for NRGN Gene

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