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NRGN Gene

protein-coding   GIFtS: 59
GCID: GC11P124609

Neurogranin (Protein Kinase C Substrate, RC3)

  See NRGN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neurogranin (Protein Kinase C Substrate, RC3)1 2     neurogranin2
RC32 3     ng2
Calmodulin-Binding Protein2     Protein Kinase C Substrate2
hng2     Ng3

External Ids:    HGNC: 80001   Entrez Gene: 49002   Ensembl: ENSG000001541467   OMIM: 6023505   UniProtKB: Q926863   
ORGUL members:         

Export aliases for NRGN gene to outside databases

Previous GC identifers: GC11P126610 GC11P126122 GC11P124643 GC11P124147 GC11P124114 GC11P120552


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRGN Gene:
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a
postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains
four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated
sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control
of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during
development as well as in adult subjects. (provided by RefSeq, Jul 2008)

GeneCards Summary for NRGN Gene:
NRGN (neurogranin (protein kinase C substrate, RC3)) is a protein-coding gene. Diseases associated with NRGN include paraneoplastic cerebellar degeneration, and jacobsen syndrome. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot: NEUG_HUMAN, Q92686
Function: Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic
development and remodeling. Binds to calmodulin in the absence of calcium (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRGN gene promoter:
         Max1   Spz1   LCR-F1   CREB   S8   deltaCREB   LyF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRGN promoter sequence
   Search Chromatin IP Primers for NRGN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24

NRGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRGN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P124609:  view genomic region     (about GC identifiers)

Start:
124,609,742 bp from pter      End:
124,617,106 bp from pter
Size:
7,365 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NEUG_HUMAN, Q92686 (See protein sequence)
Recommended Name: Neurogranin  
Size: 78 amino acids; 7618 Da

Explore the universe of human proteins at neXtProt for NRGN: NX_Q92686

Explore proteomics data for NRGN at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts
    several learning- and memory-associated functions (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NRGN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001119653.1  NP_006167.1  

    ENSEMBL proteins: 
     ENSP00000284292   ENSP00000399591  

    NRGN Human Recombinant Protein Products:

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    Novus Biologicals NRGN Protein
    Novus Biologicals NRGN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NRGN

     
    Search eBioscience for Proteins for NRGN 

     
    antibodies-online proteins for NRGN (7 products) 

     
    antibodies-online peptides for NRGN

    NRGN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NRGN
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    Abcam antibodies for NRGN
    Cloud-Clone Corp. Antibodies for NRGN
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    antibodies-online antibodies for NRGN (26 products) 

    NRGN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NRGN
    Cloud-Clone Corp. CLIAs for NRGN
    Search eBioscience for ELISAs for NRGN 
    antibodies-online kits for NRGN (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q92686

    ProtoNet protein and cluster: Q92686

    UniProtKB/Swiss-Prot: NEUG_HUMAN, Q92686
    Domain: Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical
    conformation (By similarity)
    Similarity: Belongs to the neurogranin family
    Similarity: Contains 1 collagen-like domain
    Similarity: Contains 1 IQ domain


    Find genes that share domains with NRGN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUG_HUMAN, Q92686
    Function: Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic
    development and remodeling. Binds to calmodulin in the absence of calcium (By similarity)

         Genatlas biochemistry entry for NRGN:
    neurogranin,rat Ng/RC3 homolog gene encoding a brain-specific protein expressed in telencephalic neurons,target of
    thyroid hormone in brain (thyroid hormone-responsive element in the first intron)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with NRGN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NRGN:
     Increased cell number in G1, a 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nrgn):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with NRGN           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NRGN

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NRGN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRGN (see all 28):
    hsa-miR-596 hsa-miR-148b* hsa-miR-330-5p hsa-miR-658 hsa-miR-1908 hsa-miR-650 hsa-miR-877* hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidNRGN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NRGN

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    GenScript: all cDNA clones in your preferred vector (see all 2): NRGN (NM_001126181)
    Sino Biological Human cDNA Clone for NRGN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRGN

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRGN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRGN
    Interactions:

        GeneGlobe Interaction Network for NRGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for NRGN (Q926863 ENSP000002842924) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    PRKCBP057713, ENSP000003053554I2D: score=2 STRING: ENSP00000305355
    PRKCGP051293, ENSP000002634314I2D: score=2 STRING: ENSP00000263431
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10075657
    GO:0007399nervous system development TAS10075657

    Find genes that share ontologies with NRGN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRGN (NEUG)

    1 HMDB Compound for NRGN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for NRGN gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pkcs 69.1 1 8519597 (1)
    aroclor 1254 50.4 2 10614638 (2)
    phosphatidylserine 47.3 2 7533539 (1), 7840634 (1)
    calcium 40.7 32 7840634 (3), 7896819 (3), 15469893 (2), 16797925 (2) (see all 14)
    bisphenol a 33.3 3 15498886 (2), 17412439 (1)
    nmda 27 4 9138717 (1), 17140601 (1), 10088994 (1)
    phosphatidylinositol 24.2 5 8519597 (2)
    phosphatidylcholine 18.5 5 8519597 (2)
    phospholipid 17.4 2 8611023 (1), 1826685 (1)
    phosphoinositide 13.9 1 8611023 (1)



    Find genes that share compounds with NRGN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NRGN gene (2 alternative transcripts): 
    NM_001126181.1  NM_006176.2  

    Unigene Cluster for NRGN:

    Neurogranin (protein kinase C substrate, RC3)
    Hs.524116  [show with all ESTs]
    Unigene Representative Sequence: BM548510
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284292(uc001qaq.2) ENST00000412681(uc001qar.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NRGN (see all 28):
    hsa-miR-596 hsa-miR-148b* hsa-miR-330-5p hsa-miR-658 hsa-miR-1908 hsa-miR-650 hsa-miR-877* hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidNRGN 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): NRGN (NM_001126181)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRGN
    Primer
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    OriGene qPCR primer pairs and template standards for NRGN
    OriGene qSTAR qPCR primer pairs in human, mouse for NRGN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRGN
      QuantiTect SYBR Green Assays in human, mouse, rat NRGN
      QuantiFast Probe-based Assays in human, mouse, rat NRGN

    Additional mRNA sequence: 

    BC002835.2 BT007325.1 U89165.1 Y09689.1 

    13 DOTS entries:

    DT.452566  DT.92429839  DT.95284674  DT.206890  DT.91716298  DT.92042928  DT.92414920  DT.120717876 
    DT.75102947  DT.86843104  DT.95284671  DT.100754886  DT.120717885 

    Selected AceView cDNA sequences (see all 157):

    BT007325 BM923818 BM701366 CA445014 C02047 F01422 AI498929 AI383972 
    BP350470 BQ028841 BC002835 AA777530 BX091785 AW590389 CA422673 AA354640 
    AI203843 Y09689 CA447471 BM985307 AI125174 H22488 AI355950 BE675089 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGTGCT
    NRGN Expression
    About this image


    NRGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 28 entries
             Thalamus
             Globus Pallidus   
     
     Lung (Respiratory System)
             Alveolar type II cells
    NRGN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRGN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524116

    UniProtKB/Swiss-Prot: NEUG_HUMAN, Q92686
    Tissue specificity: In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and
    basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NRGN gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrgn5 neurogranin   --   9 (20.78 cM) 37544492 
    chicken
    (Gallus gallus)
    Aves NRGN6
    neurogranin (protein kinase C substrate, RC3)
    72(a)
    1 ↔ 1
    24(294677-296798) ENSGALG00000018942
    lizard
    (Anolis carolinensis)
    Reptilia NRGN6
    neurogranin (protein kinase C substrate, RC3)
    68(a)
    1 ↔ 1
    GL343322.1(80478-80666)
    zebrafish
    (Danio rerio)
    Actinopterygii nrgna6
    neurogranin (protein kinase C substrate, RC3) a
    60(a)
    1 ↔ 1
    5(59838779-59849270) ENSDARG00000039626


    ENSEMBL Gene Tree for NRGN (if available)
    TreeFam Gene Tree for NRGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRGN gene
    1 SIMAP similar gene for NRGN using alignment to 1 protein entry:     NEUG_HUMAN:
    GAP43

    Find genes that share paralogs with NRGN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRGN (see all 143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1128823001,2
    C,F--124607897(+) GAAGGG/ACTGTG 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs718834471,2
    C--124607922(+) TGGTG-/GGGGGG 2 -- us2k10--------
    rs1815764441,2
    --124607923(+) TTGGTC/GGGGGG 2 -- us2k10--------
    rs2015004641,2
    C--124607930(+) GGGGG-/G/GG  
            
    TGTTG
    2 -- us2k10--------
    rs1479440321,2
    --124608046(+) TCACCA/GAATCC 2 -- us2k10--------
    rs1418675521,2
    --124608219(+) CAAGGA/GCCTGA 2 -- us2k10--------
    rs1455179981,2
    --124608248(+) CACTTA/GGAGGA 2 -- us2k10--------
    rs6551041,2
    C,F,A,H--124608304(-) TGTAAC/AAAAAA 2 -- us2k116Minor allele frequency- A:0.02MN NA WA CSA EA 699
    rs1841847821,2
    --124608336(+) TGCTGC/GGAGAG 2 -- us2k10--------
    rs1163486551,2
    C,F--124608486(+) CGGGCC/GCAAAC 2 -- us2k11Minor allele frequency- G:0.07WA 118

    HapMap Linkage Disequilibrium report for NRGN (124609742 - 124617106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NRGN:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1321n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): NRGN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRGN
    DNA2.0 Custom Variant and Variant Library Synthesis for NRGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602350    OMIM disorders: --

    5 diseases for NRGN:    
    About MalaCards
    paraneoplastic cerebellar degeneration    jacobsen syndrome    cerebellar degeneration    hypothyroidism
    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for NRGN:
    Schizophrenia     Hypothyroidism

    Find genes that share disorders with NRGN           About GenesLikeMe

    3 Novoseek inferred disease relationships for NRGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypothyroidism 37.2 2 12889141 (1), 7539519 (1)
    schizophrenia 14.8 8 17140601 (4), 19571808 (1)
    neurological disorders 0 1 2285268 (1)

    Genetic Association Database (GAD): NRGN
    Human Genome Epidemiology (HuGE) Navigator: NRGN (4 documents)

    Export disorders for NRGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRGN gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with NRGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN). (PubMed id 9143500)1, 2, 3, 9 Martinez de Arrieta C.... Coloma A. (Genomics 1997)
    2. Association of the gene encoding neurogranin with schizophrenia in males. (PubMed id 17140601)1, 4, 9 Ruano D....Palha J.A. (J Psychiatr Res 2008)
    3. Structure and chromosomal localization of human neurogranin gene. (PubMed id 9499372)1, 2, 9 Mertsalov I.B.... Tsetlin V.I. (Bioorg. Khim. 1997)
    4. Cloning cDNA for human neurogranin. (PubMed id 8929222)1, 2, 9 Mertsalov I.B.... Tsetlin V.I. (Bioorg. Khim. 1996)
    5. Common variants conferring risk of schizophrenia. (PubMed id 19571808)1, 4, 9 Stefansson H....Collier D.A. (Nature 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. [Neurogranin: a brain-specific protein]. (PubMed id 12889141)1, 9 Li H.Y....Lu G.W. (Sheng Li Ke Xue Jin Zhan 2003)
    8. Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor. (PubMed id 12808095)1, 9 Devireddy L.R. and Green M.R. (Mol. Cell. Biol. 2003)
    9. Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia. (PubMed id 9329454)2, 9 Chang J.W.... Watson J.B. (J. Neuropathol. Exp. Neurol. 1997)
    10. The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron. (PubMed id 9886843)1, 9 MartA-nez de Arrieta C....Bernal J. (Endocrinology 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4900 HGNC: 8000 AceView: NRGN Ensembl:ENSG00000154146 euGenes: HUgn4900
    ECgene: NRGN H-InvDB: NRGN

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRGN gene:
    Search GeneIP for patents involving NRGN

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