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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NRG4 Gene

protein-coding   GIFtS: 54
GCID: GC15M076233

Neuregulin 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuregulin 41 2
HRG42 5
Heregulin 42
pro-NRG42
Pro-Neuregulin-4, Membrane-Bound Isoform2
Pro-NRG43

External Ids:    HGNC: 298621   Entrez Gene: 1459572   Ensembl: ENSG000001697527   OMIM: 6108945   UniProtKB: Q8WWG13   

Export aliases for NRG4 gene to outside databases

Previous GC identifers: GC15M074022 GC15M052990


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NRG4 Gene:
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating
cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 (PubMed 10348342)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for NRG4 Gene: 
NRG4 (neuregulin 4) is a protein-coding gene. Diseases associated with NRG4 include transitional cell carcinoma, and breast cancer, and among its related super-pathways are GRB2 events in ERBB2 signaling and ErbB signaling pathway. GO annotations related to this gene include growth factor activity.

UniProtKB/Swiss-Prot: NRG4_HUMAN, Q8WWG1
Function: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2
coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does
not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity)

Gene Wiki entry for NRG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NRG4 gene promoter:
         AML1a   CUTL1   IRF-1   E4BP4   HFH-1   FOXJ2 (long isoform)   FOXJ2   Pax-4a   TGIF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRG4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NRG4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q23

NRG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRG4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M076233:  view genomic region     (about GC identifiers)

Start:
76,228,310 bp from pter      End:
76,352,136 bp from pter
Size:
123,827 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NRG4_HUMAN, Q8WWG1 (See protein sequence)
Recommended Name: Pro-neuregulin-4, membrane-bound isoform  
Size: 115 amino acids; 12722 Da
Subunit: Interacts with ERBB4 (By similarity)
Subcellular location: Pro-neuregulin-4, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein
(By similarity). Note=Does not seem to be active (By similarity)
Subcellular location: Neuregulin-4: Secreted (By similarity)
Secondary accessions: A6NIE8

Explore the universe of human proteins at neXtProt for NRG4: NX_Q8WWG1

Post-translational modifications:

  • UniProtKB: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth
    factor form (By similarity)
  • UniProtKB: Extensive glycosylation precedes the proteolytic cleavage (By similarity)
  • View neXtProt modification sites for NX_Q8WWG1

  • NRG4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_612640.1  
    ENSEMBL proteins: 
     ENSP00000457335   ENSP00000431810   ENSP00000432751   ENSP00000378367   ENSP00000456778  
     ENSP00000457838   ENSP00000454895   ENSP00000456029   ENSP00000455314   ENSP00000455167  
     ENSP00000436832   ENSP00000457626   ENSP00000441129   ENSP00000303071  
    Reactome Protein details: Q8WWG1
    Human Recombinant Protein Products for NRG4: 
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    Novus Biologicals NRG4 Proteins
    Novus Biologicals NRG4 Lysates
    Sino Biological Recombinant Protein for NRG4
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NRG4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    NRG4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for NRG4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry Q8WWG1

    ProtoNet protein and cluster: Q8WWG1

    1 Blocks protein domain: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: NRG4_HUMAN, Q8WWG1
    Domain: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing.
    Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity)
    Domain: ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)
    Similarity: Belongs to the neuregulin family
    Similarity: Contains 1 EGF-like domain


    NRG4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRG4_HUMAN, Q8WWG1
    Function: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2
    coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does
    not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
         
    NRG4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nrg4):
     normal 

    NRG4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NRG4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NRG4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRG4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NRG4 

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NRG4:
    hsa-miR-659 hsa-miR-544
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRG4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NRG4 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1SHC1 events in ERBB2 signaling
    SHC1 events in ERBB2 signaling0.92
    SHC1 events in ERBB4 signaling0.84
    GRB2 events in ERBB2 signaling0.92
    ErbB receptor signaling network0.34
    2ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    3Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    4PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    5Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NRG4
        Development ERBB-family signaling


    1 GeneGo (Thomson Reuters) Pathway for NRG4
        Development ERBB-family signaling

    3 BioSystems Pathways for NRG4
        ErbB signaling pathway
    ErbB4 signaling events
    ErbB receptor signaling network

    1 Sino Biological Pathway for NRG4 
        EGFR Signaling Pathway

    5/35        Reactome Pathways for NRG4 (see all 35)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF
    Downstream Signaling Events Of B Cell Receptor (BCR)


    1         Kegg Pathway  (Kegg details for NRG4):
        ErbB signaling pathway


    NRG4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRG4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/11 Interacting proteins for NRG4 (Q8WWG13 ENSP000003783674) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB4Q153033, ENSP000003422354I2D: score=1 STRING: ENSP00000342235
    CREB3O438893I2D: score=1 
    FATE1Q969F03I2D: score=1 
    EGFENSP000002651714STRING: ENSP00000265171
    EGFRENSP000002754934STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--
    GO:0045087innate immune response TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--

    NRG4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NRG4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NRG4

    1 Novoseek inferred chemical compound relationship for NRG4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 24.9 1 10348342 (1)

    Search CenterWatch for drugs/clinical trials and news about NRG4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NRG4 gene: 
    NM_138573.3  

    Unigene Cluster for NRG4:

    Neuregulin 4
    Hs.732438  [show with all ESTs]
    Unigene Representative Sequence: CR749519
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000567467 ENST00000569343 ENST00000566417 ENST00000461391(uc002bbo.3)
    ENST00000472094 ENST00000394907 ENST00000568073(uc010bkm.1) ENST00000565661
    ENST00000562114 ENST00000567936 ENST00000563204(uc002bbp.2) ENST00000563910
    ENST00000498750 ENST00000567126 ENST00000568203 ENST00000563582 ENST00000535975
    ENST00000305435
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NRG4:
    hsa-miR-659 hsa-miR-544
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    Additional mRNA sequence: 

    AK307362.1 AM392364.1 AM392365.1 AM392366.1 BC017568.1 CR749519.1 

    7 DOTS entries:

    DT.92420331  DT.101976338  DT.121074058  DT.40225171  DT.121074034  DT.91807155  DT.97806293 

    24/25 AceView cDNA sequences (see all 25):

    F29883 BF061527 AA861006 CN478955 BX538100 CA450218 BG195285 BC017568 
    BM797082 BX095400 AA884717 AI743118 BI464093 BF793585 NM_138573 CR749519 
    BE787057 BG207240 BE706435 BG217742 C00540 H56479 BF126566 H56480 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NRG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NRG4 Expression
    About this image


    Genevestigator expression for NRG4

    SOURCE GeneReport for Unigene cluster: Hs.732438
        SABiosciences Expression via Pathway-Focused PCR Array including NRG4: 
              Neurotrophins & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NRG4 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrg41 , 5 neuregulin 41, 5 82.61(n)1
    75.65(a)1
      9 (29.87 cM)5
    839611  NM_032002.21  NP_114391.11 
     552202225 
    chicken
    (Gallus gallus)
    Aves NRG41 neuregulin 4 69.47(n)
    62.62(a)
      415354  NM_001030544.1  NP_001025715.1 


    ENSEMBL Gene Tree for NRG4 (if available)
    TreeFam Gene Tree for NRG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NRG4 gene
    9 SIMAP similar genes for NRG4 using alignment to 7 protein entries:     NRG4_HUMAN (see all proteins):
    DKFZp779N0541    DKFZp779N1944    NRG3    EPGN    NRG1    NRG2
    LRP1B    EGF    TGFA

    NRG4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1379 SNPs in NRG4 are shown (see all 1379)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs773956711,2
    C--56293348(+) AAAAA-/AAAT  
            
    CTTGC
    1 -- int10--------
    rs16992751,2
    C,F,H--76233840(-) actacT/Ggtgaa 1 -- ds5001 ese313Minor allele frequency- G:0.02MN NA WA CSA 443
    rs1414086651,2
    C--76233851(+) CAAAAG/TGTAGA 1 -- ds50010--------
    rs1680431,2
    C--76233948(+) tccttC/Ttacat 1 -- ds5001 ese33Minor allele frequency- T:0.00MN NA 188
    rs740240281,2
    C,F--76234072(+) ACAAAG/AATTAC 1 -- ds50012Minor allele frequency- A:0.14WA 120
    rs48864681,2
    C,F,A,H--76234083(+) gttttG/Atcaca 1 -- ds500112Minor allele frequency- A:0.04NS EA NA 1250
    rs3357181,2
    C,H--76234092(+) cagggG/Agcagg 1 -- ds5001 ese314Minor allele frequency- A:0.01MN NA WA CSA EA 563
    rs1165225391,2
    C,F--76234226(+) TTCAAA/CATGGT 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs24558921,2
    C,A--76234279(-) tttGGG/TGGTTT 1 -- ds50010--------
    rs606392191,2
    C--76234301(+) AAAAAC/AATATG 1 -- ds50011Minor allele frequency- A:0.00WA 2

    HapMap Linkage Disequilibrium report for NRG4 (76228310 - 76352136 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NRG4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749900CNV Deletion23290073
    esv2749895CNV Deletion23290073
    esv2749898CNV Deletion23290073
    nsv518261CNV Loss19592680
    nsv518214CNV Loss19592680
    nsv904398CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610894    OMIM disorders: --

    4 diseases for NRG4:    About MalaCards
    transitional cell carcinoma    breast cancer    prostate cancer    prostatitis


    NRG4 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NRG4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 21 2 15141382 (2)
    tumors 0 6 16469638 (1)

    Genetic Association Database (GAD): NRG4
    Human Genome Epidemiology (HuGE) Navigator: NRG4 (3 documents)

    Export disorders for NRG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NRG4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NRG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. (PubMed id 10348342)1, 9 Harari D....Yarden Y. (1999)
    5. Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients. (PubMed id 15583696)1, 9 Memon A.A....Nexo E. (2004)
    6. Characterization of the cell membrane-associated products of the Neuregulin 4 gene. (PubMed id 17684490)1, 9 Hayes N.V....Gullick W.J. (2008)
    7. Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. (PubMed id 17545517)1, 9 Hayes N.V....Gullick W.J. (2007)
    8. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 Kottgen A....Gieger C. (2013)
    9. Seventy-five genetic loci influencing the human red bl ood cell. (PubMed id 23222517)1 van der Harst P....Chambers J.C. (2012)
    10. Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. (PubMed id 23033483)1 Bernard J.K....Frey M.R. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 145957 HGNC: 29862 AceView: LOC145957 Ensembl:ENSG00000169752 euGenes: HUgn145957
    ECgene: NRG4 Kegg: 145957 H-InvDB: NRG4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NRG4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NRG4 gene:
    Search GeneIP for patents involving NRG4

    Licensable Technologies for NRG4 gene:
    Weizmann Institute:"Neuregulin-4 (NRG4), a Novel Growth Factor Which Acts Through the Erbb4 Receptor Tyrosine Kinase; Sequences, Antibodies To and Uses Thereof."
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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