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Aliases for NRG4 Gene

Aliases for NRG4 Gene

  • Neuregulin 4 2 3 5
  • Pro-NRG4 3 4
  • Heregulin 4 3
  • HRG4 3

External Ids for NRG4 Gene

Previous GeneCards Identifiers for NRG4 Gene

  • GC15M074022
  • GC15M076233
  • GC15M052990

Summaries for NRG4 Gene

Entrez Gene Summary for NRG4 Gene

  • The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NRG4 Gene

NRG4 (Neuregulin 4) is a Protein Coding gene. Diseases associated with NRG4 include immunodeficiency 13 and cone-rod dystrophy. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include receptor binding and growth factor activity.

UniProtKB/Swiss-Prot for NRG4 Gene

  • Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).

Gene Wiki entry for NRG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRG4 Gene

Genomics for NRG4 Gene

Regulatory Elements for NRG4 Gene

Promoters for NRG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRG4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRG4 Gene

Chromosome:
15
Start:
75,935,969 bp from pter
End:
76,059,795 bp from pter
Size:
123,827 bases
Orientation:
Minus strand

Genomic View for NRG4 Gene

Genes around NRG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRG4 Gene

Proteins for NRG4 Gene

  • Protein details for NRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWG1-NRG4_HUMAN
    Recommended name:
    Pro-neuregulin-4, membrane-bound isoform
    Protein Accession:
    Q8WWG1
    Secondary Accessions:
    • A6NIE8

    Protein attributes for NRG4 Gene

    Size:
    115 amino acids
    Molecular mass:
    12722 Da
    Quaternary structure:
    • Interacts with ERBB4.

neXtProt entry for NRG4 Gene

Proteomics data for NRG4 Gene at MOPED

Post-translational modifications for NRG4 Gene

  • Extensive glycosylation precedes the proteolytic cleavage.
  • Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
  • Glycosylation at Asn 39

Antibody Products

No data available for DME Specific Peptides for NRG4 Gene

Domains & Families for NRG4 Gene

Protein Domains for NRG4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NRG4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WWG1

UniProtKB/Swiss-Prot:

NRG4_HUMAN :
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • Belongs to the neuregulin family.
Domain:
  • The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
  • ERBB receptor binding is elicited entirely by the EGF-like domain.
  • Contains 1 EGF-like domain.
Family:
  • Belongs to the neuregulin family.
genes like me logo Genes that share domains with NRG4: view

No data available for Gene Families for NRG4 Gene

Function for NRG4 Gene

Molecular function for NRG4 Gene

UniProtKB/Swiss-Prot Function:
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).

Gene Ontology (GO) - Molecular Function for NRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
genes like me logo Genes that share ontologies with NRG4: view

Phenotypes for NRG4 Gene

GenomeRNAi human phenotypes for NRG4:
MGI mutant phenotypes for NRG4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NRG4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NRG4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRG4 Gene

Localization for NRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRG4 Gene

Pro-neuregulin-4, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Note=Does not seem to be active. {ECO:0000250}.
Neuregulin-4: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRG4 Gene COMPARTMENTS Subcellular localization image for NRG4 gene
Compartment Confidence
extracellular 4
plasma membrane 4
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NRG4 Gene

Pathways & Interactions for NRG4 Gene

SuperPathways for NRG4 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 Signaling by ERBB2
4 Immune System
5 Downstream signaling events of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with NRG4: view

Pathways by source for NRG4 Gene

1 KEGG pathway for NRG4 Gene
1 GeneGo (Thomson Reuters) pathway for NRG4 Gene

SIGNOR curated interactions for NRG4 Gene

Activates:

Gene Ontology (GO) - Biological Process for NRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS --
genes like me logo Genes that share ontologies with NRG4: view

Drugs & Compounds for NRG4 Gene

(1) Drugs for NRG4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NRG4: view

Transcripts for NRG4 Gene

Unigene Clusters for NRG4 Gene

Neuregulin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRG4 Gene

No ASD Table

Relevant External Links for NRG4 Gene

GeneLoc Exon Structure for
NRG4
ECgene alternative splicing isoforms for
NRG4

Expression for NRG4 Gene

mRNA expression in normal human tissues for NRG4 Gene

mRNA differential expression in normal tissues according to GTEx for NRG4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.2), Brain - Cerebellum (x5.3), and Pancreas (x4.2).

SOURCE GeneReport for Unigene cluster for NRG4 Gene Hs.732438

genes like me logo Genes that share expression patterns with NRG4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NRG4 Gene

Orthologs for NRG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRG4 36
  • 98 (a)
OneToOne
NRG4 35
  • 98.84 (n)
  • 98.26 (a)
cow
(Bos Taurus)
Mammalia NRG4 35
  • 87.83 (n)
  • 86.09 (a)
dog
(Canis familiaris)
Mammalia NRG4 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrg4 16
Nrg4 36
  • 76 (a)
OneToOne
Nrg4 35
  • 82.61 (n)
  • 75.65 (a)
oppossum
(Monodelphis domestica)
Mammalia NRG4 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRG4 36
  • 41 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrg4 35
  • 84.64 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves NRG4 35
  • 69.44 (n)
  • 62.04 (a)
NRG4 36
  • 59 (a)
OneToOne
Species with no ortholog for NRG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NRG4 Gene

ENSEMBL:
Gene Tree for NRG4 (if available)
TreeFam:
Gene Tree for NRG4 (if available)

Paralogs for NRG4 Gene

genes like me logo Genes that share paralogs with NRG4: view

No data available for Paralogs for NRG4 Gene

Variants for NRG4 Gene

Sequence variations from dbSNP and Humsavar for NRG4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs334938 -- 76,006,070(-) TTCCC(A/G)GAGGC intron-variant
rs335718 -- 75,941,751(+) caggg(A/G)gcagg downstream-variant-500B
rs335719 -- 75,942,616(+) GTGAC(A/C)CACTG utr-variant-3-prime
rs335720 -- 75,943,008(+) AGTTA(C/T)TTGCA utr-variant-3-prime
rs335726 -- 75,957,454(-) agttg(C/G)aaaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRG4 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
nsv904398 CNV Gain 21882294
nsv518214 CNV Loss 19592680
nsv518261 CNV Loss 19592680
esv2749900 CNV Deletion 23290073

Variation tolerance for NRG4 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRG4 Gene

HapMap Linkage Disequilibrium report
NRG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRG4 Gene

Disorders for NRG4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NRG4 Gene - From: OMIM

Disorder Aliases PubMed IDs
immunodeficiency 13
  • icl
cone-rod dystrophy
  • cone-rod dystrophy 5
- elite association - COSMIC cancer census association via MalaCards
Search NRG4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRG4

Genetic Association Database (GAD)
NRG4
Human Genome Epidemiology (HuGE) Navigator
NRG4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRG4
genes like me logo Genes that share disorders with NRG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRG4 Gene

Publications for NRG4 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Characterization of the cell membrane-associated products of the Neuregulin 4 gene. (PMID: 17684490) Hayes N.V. … Gullick W.J. (Oncogene 2008) 3 23
  3. Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. (PMID: 17545517) Hayes N.V. … Gullick W.J. (Clin. Cancer Res. 2007) 3 23
  4. Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients. (PMID: 15583696) Memon A.A. … Nexo E. (Br. J. Cancer 2004) 3 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for NRG4 Gene

Sources for NRG4 Gene

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