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NRG3 Gene

protein-coding   GIFtS: 63
GCID: GC10P083625

Neuregulin 3

  See NRG3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuregulin 31 2     Neuregulin 3 Variant 52
HRG32     Neuregulin 3 Variant 62
Neuregulin 3 Variant 12     Neuregulin 3 Variant 72
Neuregulin 3 Variant 102     Neuregulin 3 Variant 82
Neuregulin 3 Variant 112     Neuregulin 3 Variant 92
Neuregulin 3 Variant 122     Neuregulin-3-Like Polypeptide2
Neuregulin 3 Variant 132     pro-NRG32
Neuregulin 3 Variant 142     Pro-Neuregulin-3, Membrane-Bound Isoform2
Neuregulin 3 Variant 32     Pro-NRG33
Neuregulin 3 Variant 42     

External Ids:    HGNC: 79991   Entrez Gene: 107182   Ensembl: ENSG000001857377   OMIM: 6055335   UniProtKB: P569753   

Export aliases for NRG3 gene to outside databases

Previous GC identifers: GC10U990072 GC10P083766 GC10P083299 GC10P077483


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRG3 Gene:
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane
tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand
binding activates intracellular signaling cascades and the induction of cellular responses including
proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3
has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to
influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes
mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus
for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants
encoding distinct isoforms. Additional transcript variants have been described but their biological validity has
not been verified.(provided by RefSeq, Sep 2009)

GeneCards Summary for NRG3 Gene:
NRG3 (neuregulin 3) is a protein-coding gene. Diseases associated with NRG3 include schizoaffective disorder, and schizophrenia. GO annotations related to this gene include growth factor activity and transmembrane receptor protein tyrosine kinase activator activity. An important paralog of this gene is NRG2.

UniProtKB/Swiss-Prot: NRG3_HUMAN, P56975
Function: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine
phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May
be a survival factor for oligodendrocytes

Gene Wiki entry for NRG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRG3 gene promoter:
         E2F-3a   E2F-5   E2F-1   E2F   E2F-2   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRG3 promoter sequence
   Search Chromatin IP Primers for NRG3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22-q23   Ensembl cytogenetic band:  10q23.1   HGNC cytogenetic band: 10q22-q23

NRG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRG3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P083625:  view genomic region     (about GC identifiers)

Start:
83,635,070 bp from pter      End:
84,746,935 bp from pter
Size:
1,111,866 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NRG3_HUMAN, P56975 (See protein sequence)
Recommended Name: Pro-neuregulin-3, membrane-bound isoform precursor  
Size: 720 amino acids; 77901 Da
Subunit: Interacts with ERBB4
Developmental stage: Isoform 3 is expressed in fetal brain but not in other fetal tissues
Secondary accessions: A4D7U1 Q0PEH2 Q5VYH3
Alternative splicing: 4 isoforms:  P56975-1   P56975-2   P56975-3   P56975-4   

Explore the universe of human proteins at neXtProt for NRG3: NX_P56975

Explore proteomics data for NRG3 at MOPED

Post-translational modifications: 

  • Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth
    factor form1
  • Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated1
  • Glycosylation2 at Thr276, Thr277, Thr278, Ser280, Thr281
  • Modification sites at PhosphoSitePlus

  • See NRG3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001010848.2  NP_001159444.1  NP_001159445.1  

    ENSEMBL proteins: 
     ENSP00000361214   ENSP00000384796   ENSP00000361215   ENSP00000473669   ENSP00000451858  
     ENSP00000385804   ENSP00000451376   ENSP00000441201   ENSP00000440377  
    Reactome Protein details: P56975

    NRG3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NRG3

     
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    Cloud-Clone Corp. ELISAs for NRG3
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    Search eBioscience for ELISAs for NRG3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P56975

    ProtoNet protein and cluster: P56975

    1 Blocks protein domain: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: NRG3_HUMAN, P56975
    Domain: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing.
    Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity)
    Domain: ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)
    Similarity: Belongs to the neuregulin family
    Similarity: Contains 1 EGF-like domain


    Find genes that share domains with NRG3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRG3_HUMAN, P56975
    Function: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine
    phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May
    be a survival factor for oligodendrocytes

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005515protein binding ----
    GO:0008083growth factor activity NAS9275162
    GO:0030297transmembrane receptor protein tyrosine kinase activator activity NAS9275162
    GO:0030971receptor tyrosine kinase binding NAS9275162
         
    Find genes that share ontologies with NRG3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NRG3:
     Decreased TP53 protein express  Decreased homologous recombina 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nrg3):
     endocrine/exocrine gland  integument 

    Find genes that share phenotypes with NRG3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRG3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRG3
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    hsa-miR-21* hsa-miR-100* hsa-miR-607 hsa-miR-3938 hsa-miR-562 hsa-miR-188-5p hsa-miR-4305 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector (see all 3): NRG3 (NM_001165972)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRG3_HUMAN, P56975: Pro-neuregulin-3, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein
    (By similarity). Note=Does not seem to be active (By similarity)
    NRG3_HUMAN, P56975: Neuregulin-3: Secreted (By similarity)
    NRG3_HUMAN, P56975: Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also
    proteolytically released as a soluble form
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS9275162
    GO:0005887integral component of plasma membrane NAS9275162

    Find genes that share ontologies with NRG3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NRG3 About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    ErbB receptor signaling network0.00
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59


    Find genes that share SuperPaths with NRG3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NRG3 (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for NRG3
        Development ERBB-family signaling

    3 BioSystems Pathways for NRG3
        ErbB signaling pathway
    ErbB4 signaling events
    ErbB receptor signaling network

    Selected Reactome Pathways for NRG3 (see all 10)
        GRB2 events in ERBB2 signaling
    PI3K events in ERBB2 signaling
    SHC1 events in ERBB2 signaling
    Signaling by ERBB2
    SHC1 events in ERBB4 signaling

    1 PharmGKB Pathway for NRG3
        EGFR Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for NRG3):
        ErbB signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including NRG3: 
              Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NRG3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NRG3 (P569753 ENSP000003612144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB4Q153033, ENSP000003422354I2D: score=1 STRING: ENSP00000342235
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS9275162
    GO:0007171activation of transmembrane receptor protein tyrosine kinase activity NAS9275162
    GO:0007389pattern specification process IEA--
    GO:0009790embryo development ----
    GO:0030879mammary gland development ----

    Find genes that share ontologies with NRG3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRG3

    1 Novoseek inferred chemical compound relationship for NRG3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 27.9 2 10867024 (1), 9275162 (1)

    1 PharmGKB related drug/compound annotation for NRG3 gene    About this table
    Drug/compound PharmGKB Annotation
    iloperidoneCA  



    Find genes that share compounds with NRG3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NRG3 gene (3 alternative transcripts): 
    NM_001010848.3  NM_001165972.1  NM_001165973.1  

    Unigene Cluster for NRG3:

    Neuregulin 3
    Hs.125119  [show with all ESTs]
    Unigene Representative Sequence: NM_001010848
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372141 ENST00000404547 ENST00000372142(uc021pvb.1 uc001kco.2 uc010qlz.1 uc021pvc.1 uc001kcp.2 uc001kcq.2 uc021pvd.1 uc021pve.1 uc021pvf.1 uc021pvg.1 uc021pvh.1 uc021pvi.1 uc021pvk.1 uc001kcr.2 uc021pvl.1)
    ENST00000602794 ENST00000555784 ENST00000404576 ENST00000556918 ENST00000545131
    ENST00000537893
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    hsa-miR-21* hsa-miR-100* hsa-miR-607 hsa-miR-3938 hsa-miR-562 hsa-miR-188-5p hsa-miR-4305 hsa-miR-30d
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    Additional mRNA sequence: 

    AK098823.1 AK122886.1 AK296563.1 BC136811.1 BC143665.1 DQ001411.1 DQ338459.1 DQ857894.1 
    HM068873.1 HM068874.1 HM068875.1 HM068876.1 HM068877.1 HM068878.1 HM068879.1 HM068880.1 
    HM068881.1 HM068882.1 HM068883.1 HM068884.1 HM068885.1 

    7 DOTS entries:

    DT.414526  DT.435919  DT.100654406  DT.414525  DT.40192313  DT.65288047  DT.40232947 

    Selected AceView cDNA sequences (see all 46):

    F11490 T33154 CR617978 BX375183 BI755620 Z43631 F06398 AK098823 
    AA778232 F09150 BX510200 BQ221016 AV725307 H23651 AV728505 AW964333 
    AA704915 AW237372 F02688 Z39692 BF573698 D81083 R05509 BU729696 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACATAGGA
    NRG3 Expression
    About this image


    NRG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 14 entries
             Mature B-Cells Peripheral Blood
    NRG3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRG3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125119

    UniProtKB/Swiss-Prot: NRG3_HUMAN, P56975
    Tissue specificity: Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed
    at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas,
    spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including NRG3: 
              Growth Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NRG3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrg31 , 5 neuregulin 31, 5 90.12(n)1
    91.98(a)1
      14 (22.18 cM)5
    181831  NM_001190188.11  NP_001177117.11 
     383689525 
    chicken
    (Gallus gallus)
    Aves NRG31 neuregulin 3 80.27(n)
    81.6(a)
      428937  XM_426491.4  XP_426491.4 
    lizard
    (Anolis carolinensis)
    Reptilia NRG36
    neuregulin 3
    73(a)
    1 ↔ 1
    GL343199.1(2005130-2244743)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.319782 Xenopus laevis transcribed sequence 82.88(n)    CF548062.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018824951 pro-neuregulin-3, membrane-bound isoform-like 53.27(n)
    46.73(a)
      101882495  XM_005156254.1  XP_005156311.1 


    ENSEMBL Gene Tree for NRG3 (if available)
    TreeFam Gene Tree for NRG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRG3 gene
    NRG22  NRG12  
    2 SIMAP similar genes for NRG3 using alignment to 15 protein entries:     NRG3_HUMAN (see all proteins):
    NRG1    NRG4

    Find genes that share paralogs with NRG3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRG3 (see all 22602)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1177607401,2
    C,Funtested185117386(+) CTCCCA/C/G/
            
    CTGAG
    6 P syn11EA 120
    rs2003863861,2
    --77483822(+) CTGGGA/GCTCAG 4 G syn10--------
    rs111917671,2
    C--77519840(+) ACTTGG/TTTTTT 3 -- int1 trp31Minor allele frequency- T:0.00WA 2
    rs2015707951,2
    --77646232(+) GGGGA-/GGGGGGA 3 -- int10--------
    rs1439479781,2
    C--77646237(+) GGGGG-/GAGAGAG 3 -- int10--------
    rs773544141,2
    C--77666111(+) CTTCA-/CTGCCTCC 3 -- int10--------
    rs348241981,2
    C--77670998(+) AAAAA-/AGAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1435976271,2
    C--77705642(+) GATAC-/ATATATA 3 -- int10--------
    rs1393488091,2
    C--77717807(+) GTGTG-/TATATAT 3 -- int10--------
    rs122555481,2
    C--77717808(+) TGTGTG/ATATAT 3 -- int16Minor allele frequency- A:0.09NA WA CSA 11

    HapMap Linkage Disequilibrium report for NRG3 (83635070 - 83885070 bp, first 250kb of NRG3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NRG3 (see all 90):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739006CNV Deletion23290073
    esv2738995CNV Deletion23290073
    esv2671454CNV Deletion23128226
    esv2738962CNV Deletion23290073
    esv2739029CNV Deletion23290073
    esv2660411CNV Deletion23128226
    esv2738895CNV Deletion23290073
    esv1211637CNV Deletion17803354
    esv2738951CNV Deletion23290073
    esv2738873CNV Deletion23290073

    Human Gene Mutation Database (HGMD): NRG3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRG3
    DNA2.0 Custom Variant and Variant Library Synthesis for NRG3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605533    OMIM disorders: --

    2 diseases for NRG3:    
    About MalaCards
    schizoaffective disorder    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for NRG3:
    Schizophrenia

    Find genes that share disorders with NRG3           About GenesLikeMe

    2 Novoseek inferred disease relationships for NRG3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 43.3 6 18708184 (3), 19765633 (2), 19118813 (1)
    breast cancer 15 1 15141382 (1)

    Genetic Association Database (GAD): NRG3
    Human Genome Epidemiology (HuGE) Navigator: NRG3 (15 documents)

    Export disorders for NRG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRG3 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with NRG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. (PubMed id 9275162)1, 2, 3, 9 Zhang D.... Godowski P.J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Neuregulin 3 genetic variations and susceptibility to schizophrenia in a Chinese population. (PubMed id 18708184)1, 4, 9 Wang Y.C....Liou Y.J. (Biol. Psychiatry 2008)
    3. Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival. (PubMed id 16478787)1, 2, 9 Carteron C.... Cabedo H. (J. Cell Sci. 2006)
    4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain. (PubMed id 20713722)1, 4 Kao W.T.... Law A.J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP. (PubMed id 19776380)1, 4 Iijima M....Sobue G. (Neurology 2009)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia. (PubMed id 18521091)1, 4 Volpi S....Lavedan C. (Mol. Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10718 HGNC: 7999 AceView: NRG3 Ensembl:ENSG00000185737 euGenes: HUgn10718
    ECgene: NRG3 Kegg: 10718 H-InvDB: NRG3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NRG3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NRG3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NRG3 gene:
    Search GeneIP for patents involving NRG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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