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NRG2 Gene

protein-coding   GIFtS: 59
GCID: GC05M139207

Neuregulin 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuregulin 21 2     HRG22
Divergent Of Neuregulin-11 2     pro-NRG22
Neural- And Thymus-Derived Activator For ErbB Kinases1 2     Pro-Neuregulin-2, Membrane-Bound Isoform2
NTAK2 3     Pro-NRG23
DON12     

External Ids:    HGNC: 79981   Entrez Gene: 95422   Ensembl: ENSG000001584587   OMIM: 6038185   UniProtKB: O145113   

Export aliases for NRG2 gene to outside databases

Previous GC identifers: GC05M139049 GC05M139810 GC05M139210 GC05M139255 GC05M134369


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NRG2 Gene:
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through
interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial,
neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to
that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate
distinct biological processes by acting at different sites in tissues and eliciting different biological
responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus,
but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been
described. (provided by RefSeq, May 2010)

GeneCards Summary for NRG2 Gene:
NRG2 (neuregulin 2) is a protein-coding gene. GO annotations related to this gene include growth factor activity and receptor binding. An important paralog of this gene is NRG3.

UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511
Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2
coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May
also promote the heterodimerization with the EGF receptor

Gene Wiki entry for NRG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRG2 gene promoter:
         SRF   USF1   Pax-5   Egr-1   SRF (504 AA)   Nkx2-5   Egr-4   CREB   HEN1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRG2 promoter sequence
   Search Chromatin IP Primers for NRG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23-q33   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q23-q33

NRG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRG2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M139207:  view genomic region     (about GC identifiers)

Start:
139,226,364 bp from pter      End:
139,422,884 bp from pter
Size:
196,521 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511 (See protein sequence)
Recommended Name: Pro-neuregulin-2, membrane-bound isoform precursor  
Size: 850 amino acids; 91679 Da
Subunit: Interacts with ERBB3 and ERBB4
Alternative splicing: 8 isoforms:  O14511-1   O14511-2   O14511-3   O14511-4   O14511-5   O14511-6   O14511-7   O14511-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NRG2: NX_O14511

Explore proteomics data for NRG2 at MOPED

Post-translational modifications: 

  • Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth
    factor form (By similarity)1
  • Extensive glycosylation precedes the proteolytic cleavage (By similarity)1
  • Glycosylation2 at Asn52, Asn53, Asn147, Asn278, Thr333, Thr334, Asn346
  • Modification sites at PhosphoSitePlus

  • See NRG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001171864.1  NP_004874.1  NP_053584.1  NP_053585.1  NP_053586.1  

    ENSEMBL proteins: 
     ENSP00000289422   ENSP00000354910   ENSP00000342660   ENSP00000289409   ENSP00000351323  
     ENSP00000367483   ENSP00000444235   ENSP00000438753   ENSP00000378251  
    Reactome Protein details: O14511

    NRG2 Human Recombinant Protein Products:

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    Novus Biologicals NRG2 Lysate
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for NRG2

     
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    antibodies-online proteins for NRG2 (9 products) 

     
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    NRG2 Assay Products:

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    Cloud-Clone Corp. ELISAs for NRG2
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    antibodies-online kits for NRG2 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR002154 Neuregulin_1_C
     IPR000742 EG-like_dom
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry O14511

    ProtoNet protein and cluster: O14511

    3 Blocks protein domains:
    IPB002154 Neuregulin family signature
    IPB003598 Immunoglobulin C-2 type
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511
    Domain: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing.
    Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity)
    Domain: ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)
    Similarity: Belongs to the neuregulin family
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    Find genes that share domains with NRG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRG2_HUMAN, O14511
    Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2
    coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May
    also promote the heterodimerization with the EGF receptor

         Genatlas biochemistry entry for NRG2:
    neuregulin 2 multipotent epidermal growth factor-like factor with several splice variants,expressed in adult brain
    and developing heart,binding ERBB3 and ERBB4,involved in growth and differentiation of epithelial,neuronal,glial
    and other cell types

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9168114
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with NRG2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NRG2:
     Decreased G3BP1 protein expres  Synthetic lethal with imatinib 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nrg2):
     growth/size/body  mortality/aging  reproductive system 

    Find genes that share phenotypes with NRG2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nrg2tm1Bus for NRG2

       genOway: Develop your customized and physiologically relevant rodent model for NRG2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NRG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRG2 (see all 46):
    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-328 hsa-miR-3607-3p hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidNRG2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NRG2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 5): NRG2 (NM_013981)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRG2_HUMAN, O14511: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein
    (By similarity). Note=Does not seem to be active (By similarity)
    NRG2_HUMAN, O14511: Neuregulin-2: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    cytosol2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NRG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NRG2 About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    ErbB receptor signaling network0.00
    2Development EGFR signaling pathway
    Development ERBB family signaling0.57
    GRB7 events in ERBB2 signaling0.00
    3Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    4Signaling by FGFR
    Signaling by FGFR0.91
    Signaling by PDGF0.87
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.83
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR in Cancer0.82
    Downstream signal transduction0.90
    NGF signalling via TRKA from the plasma membrane0.71
    5PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72


    Find genes that share SuperPaths with NRG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NRG2 (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for NRG2
        Development ERBB-family signaling

    3 BioSystems Pathways for NRG2
        ErbB signaling pathway
    ErbB receptor signaling network
    ErbB2/ErbB3 signaling events

    Selected Reactome Pathways for NRG2 (see all 12)
        Downregulation of ERBB2:ERBB3 signaling
    GRB7 events in ERBB2 signaling
    GRB2 events in ERBB2 signaling
    PI3K events in ERBB2 signaling
    SHC1 events in ERBB2 signaling

    1 PharmGKB Pathway for NRG2
        EGFR Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for NRG2):
        ErbB signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRG2: 
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NRG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for NRG2 (O145113 ENSP000002894224) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB3P218603, ENSP000002671014I2D: score=3 STRING: ENSP00000267101
    ERBB4Q153033, ENSP000003422354I2D: score=2 STRING: ENSP00000342235
    ERBB2ENSP000002695714STRING: ENSP00000269571
    ERBB2IPENSP000003703304STRING: ENSP00000370330
    EREGENSP000002448694STRING: ENSP00000244869
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9168114
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009790embryo development IEA--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    Find genes that share ontologies with NRG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRG2

    2 Novoseek inferred chemical compound relationships for NRG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 41.2 3 9168115 (2), 16462207 (1)
    acetylcholine 24.1 4 15207852 (1), 16944454 (1), 15961242 (1)



    Find genes that share compounds with NRG2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NRG2 gene (7 alternative transcripts): 
    NM_001184935.1  NM_004883.2  NM_013981.3  NM_013982.2  NM_013983.2  NM_013984.1  NM_013985.1  

    Unigene Cluster for NRG2:

    Neuregulin 2
    Hs.408515  [show with all ESTs]
    Unigene Representative Sequence: NM_013982
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289422 ENST00000361474 ENST00000340391 ENST00000289409 ENST00000358522
    ENST00000378238 ENST00000519478 ENST00000518130 ENST00000541337(uc003lev.2 uc003lew.2 uc003lex.2 uc003ley.2 uc021yed.1)
    ENST00000545385 ENST00000394770
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    hsa-miR-3678-3p hsa-miR-4254 hsa-miR-328 hsa-miR-3607-3p hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-124
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    Additional mRNA sequence: 

    AB005060.1 BC103983.1 BC103984.1 BC107068.2 BC114333.1 BC114334.1 U92987.1 

    8 DOTS entries:

    DT.306524  DT.120797475  DT.91668529  DT.95283893  DT.100743126  DT.120797490  DT.40256392  DT.120797462 

    Selected AceView cDNA sequences (see all 38):

    NM_013984 AW297193 AB005060 BF435400 NM_013981 NM_013982 NM_004883 BF108794 
    CK819047 BX281777 NM_013985 NM_013983 CK819048 AW188240 BM126549 AK124504 
    AI660204 BF058845 BF059101 BF058128 BM126172 BM126469 U92987 AW002861 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCGCAGCT
    NRG2 Expression
    About this image


    NRG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
    NRG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408515

    UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511
    Tissue specificity: Restricted to the cerebellum in the adult

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NRG2: 
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NRG2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrg21 , 5 neuregulin 21, 5 91.01(n)1
    96.43(a)1
      18 (19.38 cM)5
    1000421501  NM_001167891.11  NP_001161363.11 
     360177075 
    chicken
    (Gallus gallus)
    Aves NRG21 neuregulin 2 73.48(n)
    75.51(a)
      427606  XM_003642041.2  XP_003642089.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRG26
    neuregulin 2
    72(a)
    1 ↔ 1
    4(78570325-78649366)
    zebrafish
    (Danio rerio)
    Actinopterygii nrg2a1 neuregulin 2a 66.83(n)
    63.61(a)
      100006951  NM_001099254.1  NP_001092724.1 


    ENSEMBL Gene Tree for NRG2 (if available)
    TreeFam Gene Tree for NRG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRG2 gene
    NRG32  NRG12  
    3 SIMAP similar genes for NRG2 using alignment to 4 protein entries:     NRG2_HUMAN (see all proteins):
    EGF    NRG1    NRG4

    Find genes that share paralogs with NRG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRG2 (see all 3329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172449461,2
    F--139225892(+) CAGCTG/CTGGTC 5 -- ds50011Minor allele frequency- C:0.03EA 120
    rs105906801,2
    C--139225916(+) GTACC-/ACTGTTAT 5 -- ds50010--------
    rs8890211,2
    C,F,H--139226026(-) GGTGGG/TTGAGG 5 -- ds500121Minor allele frequency- T:0.02EA NA NS WA CSA 1499
    rs1397784731,2
    --139226098(+) TCCAAC/TGCTGA 5 -- ds50010--------
    rs1886930841,2
    C--139226150(+) CCCCAA/GCAGCC 5 -- ds50010--------
    rs1149850511,2
    C,F--139226550(+) CTGGAG/AACGAG 5 -- ut311Minor allele frequency- A:0.02WA 118
    rs1498095441,2
    C--139226664(+) TCCCAA/GCGTGA 5 -- ut310--------
    rs732694951,2
    C,F--139226735(+) ACGACC/TTGTAA 5 -- ut312Minor allele frequency- T:0.05WA 120
    rs759564451,2
    C,F--139226882(+) TAACAG/ACTGTG 5 -- ut311Minor allele frequency- A:0.08WA 118
    rs1449932671,2
    --139226947(+) TACCCC/TAGCTC 5 -- ut310--------

    HapMap Linkage Disequilibrium report for NRG2 (139226364 - 139422884 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for NRG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1004341CNV Deletion20482838
    esv2667289CNV Deletion23128226
    esv2674763CNV Deletion23128226
    esv272607CNV Insertion20981092
    esv267857CNV Insertion20981092
    esv26674CNV Loss19812545
    nsv830506CNV Loss17160897
    nsv526406CNV Gain19592680
    nsv471051CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRG2
    DNA2.0 Custom Variant and Variant Library Synthesis for NRG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603818    OMIM disorders: --


    Find genes that share disorders with NRG2           About GenesLikeMe

    1 Novoseek inferred disease relationship for NRG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 30.5 1 9866830 (1)

    Genetic Association Database (GAD): NRG2
    Human Genome Epidemiology (HuGE) Navigator: NRG2 (4 documents)

    Export disorders for NRG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRG2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with NRG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human neuregulin 2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q. (PubMed id 10369162)1, 2, 9 Ring H.Z.... Francke U. (Hum. Genet. 1999)
    2. Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene. (PubMed id 17563728)1, 4, 9 Fan B.J....Pang C.P. (Mol. Vis. 2007)
    3. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. (PubMed id 9168115)1, 3, 9 Carraway K.L. III... Lai C. (Nature 1997)
    4. A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4. (PubMed id 9348101)1, 2, 9 Higashiyama S....Ishiguro H. (J. Biochem. 1997)
    5. Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. (PubMed id 9199335)1, 2, 9 Busfield S.J....Gearing D.P. (Mol. Cell. Biol. 1997)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia. (PubMed id 17598910)1, 4 Benzel I....Purvis I. (Behav Brain Funct 2007)
    8. Ligands for ErbB-family receptors encoded by a neuregulin-like gene. (PubMed id 9168114)1, 3 Chang H....McMahan U.J. (Nature 1997)
    9. Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing. (PubMed id 15961242)1, 9 Ponomareva O.N....Rimer M. (Neuroscience 2005)
    10. Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA. (PubMed id 10974560)1, 9 Yamada K....Nagatsu T. (Gene 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9542 HGNC: 7998 AceView: NRG2 Ensembl:ENSG00000158458 euGenes: HUgn9542
    ECgene: NRG2 Kegg: 9542 H-InvDB: NRG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRG2 gene:
    Search GeneIP for patents involving NRG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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