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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NRG2 Gene

protein-coding GIFtS: 57
GCID: GC05M139207

neuregulin 2

Explore 13 diseases affiliated with
NRG2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neuregulin 2¹ ²		Divergent Of Neuregulin-1²
NTAK¹ ² ³		Neural- And Thymus-Derived Activator For ErbB Kinases²
HRG2¹ ²		Pro-NRG2³
Don-1¹		Pro-Neuregulin-2, Membrane-Bound Isoform²
DON1²		Pro-NRG2³

External Ids:	HGNC: 7998¹	Entrez Gene: 9542²	Ensembl: ENSG00000158458⁷	OMIM: 603818⁵	UniProtKB: O14511³

Export aliases for NRG2 gene to outside databases

Previous GC identifers: GC05M139049 GC05M139810 GC05M139210 GC05M139255 GC05M134369

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NRG2:

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction

with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial,

and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1,

another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes

by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located

close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.

Alternative transcript variants encoding distinct isoforms have been described. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511

Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2

coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also

promote the heterodimerization with the EGF receptor

Gene Wiki entry for NRG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NRG2 gene promoter:
SRF USF1 Pax-5 Egr-1 SRF (504 AA) Nkx2-5 Egr-4 CREB HEN1 USF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NRG2 promoter sequence

Search SABiosciences Chromatin IP Primers for NRG2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRG2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23-q33 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q23-q33

NRG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRG2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M139207: view genomic region (about GC identifiers)

Start:	139,226,364 bp from pter	End:	139,422,884 bp from pter
Size:	196,521 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511 (See protein sequence)

Recommended Name: Pro-neuregulin-2, membrane-bound isoform precursor

Size: 850 amino acids; 91679 Da

Subunit: Interacts with ERBB3 and ERBB4

Subcellular location: Pro-neuregulin-2, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein (By

similarity). Note=Does not seem to be active (By similarity)

Subcellular location: Neuregulin-2: Secreted (By similarity)

Alternative splicing: 8 isoforms: O14511-1 O14511-2 O14511-3 O14511-4 O14511-5 O14511-6 O14511-7 O14511-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NRG2: NX_O14511

Post-translational modifications:

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth

factor form (By similarity)¹

Extensive glycosylation precedes the proteolytic cleavage (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14511

NRG2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001171864.1 NP_004874.1 NP_053584.1 NP_053585.1 NP_053586.1

ENSEMBL proteins:

ENSP00000289422 ENSP00000354910 ENSP00000342660 ENSP00000289409 ENSP00000351323

ENSP00000367483 ENSP00000444235 ENSP00000438753 ENSP00000378251

Reactome Protein details: O14511
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	Uscn Proteins for NRG2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

NRG2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NRG2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR002154 Neuregulin_1_C

IPR000742 EG-like_dom

IPR013098 Ig_I-set

Graphical View of Domain Structure for InterPro Entry O14511

ProtoNet protein and cluster: O14511

3 Blocks protein families:

IPB002154 Neuregulin family signature

IPB003598 Immunoglobulin C-2 type

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511

Domain: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation

of the proteolytic processing involves initial intracellular domain dimerization (By similarity)

Domain: ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)

Similarity: Belongs to the neuregulin family

Similarity: Contains 1 EGF-like domain

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511

Function: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2

coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also

promote the heterodimerization with the EGF receptor

Genatlas biochemistry entry for NRG2:

neuregulin 2 multipotent epidermal growth factor-like factor with several splice variants,expressed in adult brain and

developing heart,binding ERBB3 and ERBB4,involved in growth and differentiation of epithelial,neuronal,glial and other

cell types

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		hsa-miR-3678-3p hsa-miR-4254 hsa-miR-328 hsa-miR-3607-3p hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-124

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRG2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005006	epidermal growth factor-activated receptor activity	--	--
GO:0005102	receptor binding	TAS	9168114
GO:0005154	epidermal growth factor receptor binding	--	--
GO:0008083	growth factor activity	IEA	--
GO:0043125	ErbB-3 class receptor binding	--	--

NRG2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NRG2:

Decreased G3BP1 protein expres

Synthetic lethal with imatinib

Animal Models:
Mouse knock-out Nrg2^tm1Bus for NRG2
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nrg2):

growth/size

mortality/aging

reproductive system

NRG2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/27 super-pathways (see all 27) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PIP3 activates AKT signaling

8/10 pathways (see all 10)
PIP3 activates AKT signaling	1.00	PI3K/AKT activation	0.97
PI3K/AKT Signaling in Cancer	1.00	GAB1 signalosome	0.96
PI3K events in ERBB2 signaling	1.00	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI3K events in ERBB4 signaling	1.00	Signaling by SCF-KIT	0.72

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NRG2

Development ERBB-family signaling

5/58 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NRG2 (see all 58)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 GeneGo (Thomson Reuters) Pathway for NRG2

Development ERBB-family signaling

3 BioSystems Pathways for NRG2

	ErbB signaling pathway
	ErbB receptor signaling network
	ErbB2/ErbB3 signaling events

5/35 Reactome Pathways for NRG2 (see all 35)

	Signaling by EGFR in Cancer
	Downregulation of ERBB2:ERBB3 signaling
	Downstream signal transduction
	Signal Transduction
	Signaling by PDGF

1 PharmGKB Pathway for NRG2

EGFR Inhibitor Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for NRG2):

ErbB signaling pathway

NRG2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NRG2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/11 Interacting proteins for NRG2 (O14511³ ENSP00000289422⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB3	P21860³, ENSP00000267101⁴	I2D: score=3 STRING: ENSP00000267101
ERBB4	Q15303³, ENSP00000342235⁴	I2D: score=2 STRING: ENSP00000342235
ERBB2	ENSP00000269571⁴	STRING: ENSP00000269571
EREG	ENSP00000244869⁴	STRING: ENSP00000244869
HBEGF	ENSP00000230990⁴	STRING: ENSP00000230990

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9168114
GO:0007173	epidermal growth factor receptor signaling pathway	--	--
GO:0009790	embryo development	IEA	--

NRG2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NRG2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NRG2
2 Novoseek chemical compound relationships for NRG2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	41.2	3	9168115 (2), 16462207 (1)
acetylcholine	24.1	4	15207852 (1), 16944454 (1), 15961242 (1)

Search CenterWatch for drugs/clinical trials and news about NRG2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NRG2 gene (7 alternative transcripts):

NM_001184935.1 NM_004883.2 NM_013981.3 NM_013982.2 NM_013983.2 NM_013984.1 NM_013985.1

Unigene Cluster for NRG2:

Neuregulin 2

Hs.408515 [show with all ESTs]

Unigene Representative Sequence: NM_013982

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000289422 ENST00000361474 ENST00000340391 ENST00000289409 ENST00000358522

ENST00000378238 ENST00000519478 ENST00000518130 ENST00000541337(uc003lev.2 uc003lew.2 uc003lex.2 uc003ley.2 uc021yed.1)

ENST00000545385 ENST00000394770

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		hsa-miR-3678-3p hsa-miR-4254 hsa-miR-328 hsa-miR-3607-3p hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-124

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Additional cDNA sequence:

AB005060.1 BC103983.1 BC103984.1 BC107068.2 BC114333.1 BC114334.1 U92987.1

8 DOTS entries:

DT.306524 DT.120797475 DT.91668529 DT.95283893 DT.100743126 DT.120797490 DT.40256392 DT.120797462

24/38 AceView cDNA sequences (see all 38):

NM_013981 NM_013982 AW188240 NM_013985 AW297193 CK819048 BX281777 BF108794

NM_013984 CK819047 NM_004883 AB005060 NM_013983 BF435400 BF058845 AI073386

BM126469 BF058128 BM126172 BM126549 U92987 BX089049 AK124504 BF059101

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NRG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCGCAGCT

About this image

NRG2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NRG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NRG2

SOURCE GeneReport for Unigene cluster: Hs.408515

UniProtKB/Swiss-Prot: NRG2_HUMAN, O14511

Tissue specificity: Restricted to the cerebellum in the adult

SABiosciences Expression via Pathway-Focused PCR Arrays including NRG2:

Growth Factors in human mouse rat

Neurotrophins & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NRG2 gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nrg2^{1 , 5}	neuregulin 2^{1, 5}	91.28(n)¹ 95.5(a)¹		18 (19.38 cM)⁵ 100042150¹ NM_001167891.1¹ NP_001161363.1¹ 36017707⁵
chicken (Gallus gallus)	Aves	NRG2¹	neuregulin 2	73.96(n) 76.81(a)		427606 XM_003642041.1 XP_003642089.1
lizard (Anolis carolinensis)	Reptilia	NRG2⁶	--	73(a)	1 ↔ 1	4(78570325-78647353)
zebrafish (Danio rerio)	Actinopterygii	nrg2a¹	neuregulin 2a	62.84(n) 57.76(a)		100006951 NM_001099254.1 NP_001092724.1

ENSEMBL Gene Tree for NRG2 (if available)
TreeFam Gene Tree for NRG2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NRG2 gene

NRG3² NRG1²

3 SIMAP similar genes for NRG2 using alignment to 4 protein entries: NRG2_HUMAN (see all proteins):

EGF NRG1 NRG4

NRG2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34425274^1,2	C	--	134413387(+)	`CTTTC-/TTTTTT`	1	--	int¹		0	--	--	--	--
rs117244946^1,2	F,	--	139225892(+)	`CAGCTG/CTGGTC`	5	--	ds500¹		1		EA	120
rs10590680^1,2	C,	--	139225916(+)	`GTACC-/ACTGTTAT`	5	--	ds500¹		0	--	--	--	--
rs889021^1,2	C,F,H,	--	139226026(-)	`GGTGGG/TTGAGG`	5	--	ds500¹		21		EA NA NS WA CSA	1499
rs139778473^1,2		--	139226098(+)	`TCCAAC/TGCTGA`	5	--	ds500¹		0	--	--	--	--
rs188693084^1,2		--	139226150(+)	`CCCCAA/GCAGCC`	5	--	ds500¹		0	--	--	--	--
rs114985051^1,2	F,	--	139226550(+)	`CTGGAG/AACGAG`	5	--	ut3¹		1		WA	118
rs149809544^1,2		--	139226664(+)	`TCCCAA/GCGTGA`	5	--	ut3¹		0	--	--	--	--
rs73269495^1,2	C,	--	139226735(+)	`ACGACC/TTGTAA`	5	--	ut3¹		2		WA	120
rs75956445^1,2	F,	--	139226882(+)	`TAACAG/ACTGTG`	5	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for NRG2 (139226364 - 139422884 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NRG2
3 CNVs: 81056 64315 93253
1 Indel: 93254

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NRG2 for disorders           About GeneDecksing

OMIM gene information: 603818    OMIM disorders: --

13 diseases for NRG2:    About MalaCards

charcot-marie-tooth disease tooth disease transitional cell carcinoma neuronitis

pheochromocytoma glaucoma multiple myeloma myeloma

breast cancer schizophrenia carcinoma pancreatitis

adenocarcinoma

1 Novoseek disease relationship for NRG2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	30.5	1	9866830 (1)

Human Genome Epidemiology (HuGE) Navigator: NRG2 (4 documents)

Export disorders for NRG2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NRG2 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with NRG2)

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The human neuregulin 2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q. (PubMed id 10369162)^{1, 2, 9} Ring H.Z.... Francke U. (1999)
Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. (PubMed id 9168115)^{1, 3, 9} Carraway K.L....Lai C. (1997)
A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4. (PubMed id 9348101)^{1, 2, 9} Higashiyama S....Ishiguro H. (1997)
Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus. (PubMed id 9199335)^{1, 2, 9} Busfield S.J....Gearing D.P. (1997)
Ligands for ErbB-family receptors encoded by a neuregulin-like gene. (PubMed id 9168114)^{1, 3} Chang H....McMahan U.J. (1997)
Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene. (PubMed id 17563728)^{1, 9} Fan B.J....Pang C.P. (2007)
Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing. (PubMed id 15961242)^{1, 9} Ponomareva O.N....Rimer M. (2005)
Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA. (PubMed id 10974560)^{1, 9} Yamada K....Nagatsu T. (2000)
The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis. (PubMed id 14722120)^{1, 9} Nakano N....Wada Y. (2004)
ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis. (PubMed id 17962208)^{1, 9} Revillion F....Peyrat J.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9542	HGNC: 7998	AceView: NRG2	Ensembl:ENSG00000158458	euGenes: HUgn9542
ECgene: NRG2	Kegg: 9542	H-InvDB: NRG2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NRG2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NRG2 gene
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Patent Information for NRG2 gene:
Search GeneIP for patents involving NRG2

GeneCards and IP:
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