Aliases for NRG1 Gene
External Ids for NRG1 Gene
Previous HGNC Symbols for NRG1 Gene
Previous GeneCards Identifiers for NRG1 Gene
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
GeneCards Summary for NRG1 Gene
NRG1 (Neuregulin 1) is a Protein Coding gene. Diseases associated with NRG1 include Schizophrenia and Malignant Peripheral Nerve Sheath Tumor. Among its related pathways are p70S6K Signaling and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is NRG3.
UniProtKB/Swiss-Prot for NRG1 Gene
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.