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Aliases for NRF1 Gene

Aliases for NRF1 Gene

  • Nuclear Respiratory Factor 1 2 3
  • Alpha Palindromic-Binding Protein 2 3 4
  • ALPHA-PAL 3 4
  • NRF-1 4

External Ids for NRF1 Gene

Summaries for NRF1 Gene

Entrez Gene Summary for NRF1 Gene

  • This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

GeneCards Summary for NRF1 Gene

NRF1 (Nuclear Respiratory Factor 1) is a Protein Coding gene. Diseases associated with NRF1 include skin carcinoma in situ. Among its related pathways are Metabolism and Metabolism.

UniProtKB/Swiss-Prot for NRF1 Gene

  • Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication

Gene Wiki entry for NRF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRF1 Gene

Genomics for NRF1 Gene

Genomic Location for NRF1 Gene

Start:
129,611,714 bp from pter
End:
129,757,082 bp from pter
Size:
145,369 bases
Orientation:
Plus strand

Genomic View for NRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRF1 Gene

Regulatory Elements for NRF1 Gene

Proteins for NRF1 Gene

  • Protein details for NRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16656-NRF1_HUMAN
    Recommended name:
    Nuclear respiratory factor 1
    Protein Accession:
    Q16656
    Secondary Accessions:
    • A8K4C6
    • B4DDV6
    • Q15305
    • Q96AN2

    Protein attributes for NRF1 Gene

    Size:
    503 amino acids
    Molecular mass:
    53541 Da
    Quaternary structure:
    • Homodimer. Binds DNA as a dimer. Interacts with PPRC1.

    Alternative splice isoforms for NRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRF1 Gene

Proteomics data for NRF1 Gene at MOPED

Post-translational modifications for NRF1 Gene

Other Protein References for NRF1 Gene

No data available for DME Specific Peptides for NRF1 Gene

Domains for NRF1 Gene

Protein Domains for NRF1 Gene

Suggested Antigen Peptide Sequences for NRF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16656

UniProtKB/Swiss-Prot:

NRF1_HUMAN
Family:
  • Belongs to the NRF1/Ewg family.:
    • Q16656
genes like me logo Genes that share domains with NRF1: view

No data available for Gene Families for NRF1 Gene

Function for NRF1 Gene

Molecular function for NRF1 Gene

GENATLAS Biochemistry: nuclear respiratory factor 1,involved in the regulation of mitochondrial biogenesis and in oxidative phosphorylation
UniProtKB/Swiss-Prot Function: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication

Gene Ontology (GO) - Molecular Function for NRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 19674972
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 19674972
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRF1: view

Phenotypes for NRF1 Gene

MGI mutant phenotypes for NRF1:
inferred from 1 alleles
GenomeRNAi human phenotypes for NRF1:
genes like me logo Genes that share phenotypes with NRF1: view

miRNA for NRF1 Gene

miRTarBase miRNAs that target NRF1
Targeting motifs for NRF1 Gene
HOMER Transcription Factor Regulatory Elements motif NRF1
  • Consensus sequence: CTGCGCATGCGC Submotif: canonical Cell Type: MCF7

No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targeting for NRF1 Gene

Localization for NRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRF1 Gene COMPARTMENTS Subcellular localization image for NRF1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NRF1: view

Pathways for NRF1 Gene

genes like me logo Genes that share pathways with NRF1: view

Pathways by source for NRF1 Gene

Gene Ontology (GO) - Biological Process for NRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006091 generation of precursor metabolites and energy TAS 7629110
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8034649
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with NRF1: view

Compounds for NRF1 Gene

(5) HMDB Compounds for NRF1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Heme
  • (protoporphyrinato)iron
14875-96-8
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(13) Novoseek inferred chemical compound relationships for NRF1 Gene

Compound -log(P) Hits PubMed IDs
pgc1 77.2 1
aicar 51.3 2
citrate 41.8 1
atp 33.7 4
oxygen 29.9 5
genes like me logo Genes that share compounds with NRF1: view

Transcripts for NRF1 Gene

Unigene Clusters for NRF1 Gene

Nuclear respiratory factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for NRF1 Gene

GeneLoc Exon Structure for
NRF1
ECgene alternative splicing isoforms for
NRF1

Expression for NRF1 Gene

mRNA expression in normal human tissues for NRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRF1 Gene

SOURCE GeneReport for Unigene cluster for NRF1 Gene Hs.654363

mRNA Expression by UniProt/SwissProt for NRF1 Gene

Q16656-NRF1_HUMAN
Tissue specificity: Ubiquitously expressed with strongest expression in skeletal muscle
genes like me logo Genes that share expressions with NRF1: view

No data available for mRNA differential expression in normal tissues for NRF1 Gene

Orthologs for NRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRF1 35
  • 99.8 (n)
  • 100 (a)
NRF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRF1 35
  • 92.63 (n)
  • 99.75 (a)
NRF1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRF1 35
  • 93.9 (n)
  • 99.6 (a)
NRF1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrf1 35
  • 91.85 (n)
  • 99.78 (a)
Nrf1 16
Nrf1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRF1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRF1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrf1 35
  • 91.85 (n)
  • 99.78 (a)
chicken
(Gallus gallus)
Aves F 36
  • 99 (a)
OneToOne
NRF1 35
  • 83.43 (n)
  • 99.01 (a)
lizard
(Anolis carolinensis)
Reptilia NRF1 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3115 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nrf1 35
  • 77.76 (n)
  • 91.63 (a)
Str.3769 35
zebrafish
(Danio rerio)
Actinopterygii nrf1 35
  • 75.96 (n)
  • 91.83 (a)
nrf1 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ewg 36
  • 24 (a)
OneToOne
ewg 37
  • 60 (a)
Species with no ortholog for NRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRF1 Gene

ENSEMBL:
Gene Tree for NRF1 (if available)
TreeFam:
Gene Tree for NRF1 (if available)

Paralogs for NRF1 Gene

No data available for Paralogs for NRF1 Gene

Variants for NRF1 Gene

Sequence variations from dbSNP and Humsavar for NRF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs753947 -- 129,613,012(+) CTGGT(A/G)TCAAT intron-variant
rs1562833 -- 129,610,695(+) ATTAT(A/G)TGCAT upstream-variant-2KB
rs1668467 -- 129,611,180(+) GAGAC(A/C)CCTAG upstream-variant-2KB
rs1668468 -- 129,611,239(+) TGTAC(A/C)AAAAC upstream-variant-2KB
rs1806626 -- 129,689,833(-) GCCAC(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRF1 Gene

Variant ID Type Subtype PubMed ID
esv2674051 CNV Deletion 23128226
nsv5948 CNV Insertion 18451855
esv23078 CNV Gain 19812545
nsv516024 CNV Gain+Loss 19592680

Relevant External Links for NRF1 Gene

HapMap Linkage Disequilibrium report
NRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRF1 Gene

Disorders for NRF1 Gene

(1) MalaCards Diseases for NRF1 Gene

Search for NRF1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for NRF1 Gene

(7) Novoseek inferred disease relationships for NRF1 Gene

Disease -log(P) Hits PubMed IDs
mitochondrial diseases 43.2 1
oncocytoma 32 1
niddm 7.44 1
breast cancer 0 1
tumors 0 1

Relevant External Links for NRF1

Genetic Association Database (GAD)
NRF1
Human Genome Epidemiology (HuGE) Navigator
NRF1
genes like me logo Genes that share disorders with NRF1: view

No data available for UniProtKB/Swiss-Prot for NRF1 Gene

Publications for NRF1 Gene

  1. Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. (PMID: 7629110) Gopalakrishnan L. … Scarpulla R.C. (J. Biol. Chem. 1995) 3 4 23
  2. A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development. (PMID: 8034649) Efiok B.J.S. … Safer B. (J. Biol. Chem. 1994) 3 4 23
  3. NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. (PMID: 8253388) Virbasius C.A. … Scarpulla R.C. (Genes Dev. 1993) 3 4 23
  4. The pre-mRNA of nuclear respiratory factor 1, a regulator of mitochondrial biogenesis, is alternatively spliced in human tissues and cell lines. (PMID: 8541844) Spelbrink J.N. … Van den Bogert C. (Hum. Mol. Genet. 1995) 3 4 23
  5. Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding. (PMID: 9228045) Gugneja S. … Scarpulla R.C. (J. Biol. Chem. 1997) 3 4 23

Products for NRF1 Gene

  • Addgene plasmids for NRF1

Sources for NRF1 Gene

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