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Aliases for NREP Gene

Aliases for NREP Gene

  • Neuronal Regeneration Related Protein 2 3
  • Neuronal Protein 3.1 2 3 4
  • Protein P311 3 4
  • C5orf13 3 4
  • P311 3 4
  • Neuronal Regeneration Related Protein Homolog (Rat) 2
  • Neuronal Regeneration Related Protein Homolog 3
  • Chromosome 5 Open Reading Frame 13 2
  • PRO1873 3
  • D4S114 3
  • PTZ17 3
  • SEZ17 3

External Ids for NREP Gene

Previous HGNC Symbols for NREP Gene

  • C5orf13

Previous GeneCards Identifiers for NREP Gene

  • GC05M110999

Summaries for NREP Gene

GeneCards Summary for NREP Gene

NREP (Neuronal Regeneration Related Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NREP Gene

  • May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Gene Wiki entry for NREP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NREP Gene

Genomics for NREP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NREP Gene

Chromosome:
5
Start:
111,662,621 bp from pter
End:
111,997,464 bp from pter
Size:
334,844 bases
Orientation:
Minus strand

Genomic View for NREP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NREP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NREP Gene

No data available for Regulatory Elements for NREP Gene

Proteins for NREP Gene

  • Protein details for NREP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16612-NREP_HUMAN
    Recommended name:
    Neuronal regeneration-related protein
    Protein Accession:
    Q16612
    Secondary Accessions:
    • B2RDN8
    • B7Z5D2
    • D3DSZ8

    Protein attributes for NREP Gene

    Size:
    68 amino acids
    Molecular mass:
    7909 Da
    Quaternary structure:
    • Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction (By similarity). Interacts with FLNA.

    Alternative splice isoforms for NREP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NREP Gene

Proteomics data for NREP Gene at MOPED

Post-translational modifications for NREP Gene

  • Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NREP Gene

Domains & Families for NREP Gene

Protein Domains for NREP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NREP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NREP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NREP Gene

Function for NREP Gene

Molecular function for NREP Gene

UniProtKB/Swiss-Prot Function:
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in emphysematous lung compared to normal lung.

Gene Ontology (GO) - Molecular Function for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365962
genes like me logo Genes that share ontologies with NREP: view

Phenotypes for NREP Gene

genes like me logo Genes that share phenotypes with NREP: view

Animal Models for NREP Gene

MGI Knock Outs for NREP:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NREP Gene

Localization for NREP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NREP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NREP Gene COMPARTMENTS Subcellular localization image for NREP gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NREP: view

Pathways & Interactions for NREP Gene

SuperPathways for NREP Gene

No Data Available

Gene Ontology (GO) - Biological Process for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0031103 axon regeneration IEA --
GO:0045664 regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with NREP: view

No data available for Pathways by source and SIGNOR curated interactions for NREP Gene

Drugs & Compounds for NREP Gene

No Compound Related Data Available

Transcripts for NREP Gene

Unigene Clusters for NREP Gene

Neuronal regeneration related protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NREP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NREP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - -
SP16: - - - - - - - - -
SP17: - - - - - -
SP18: - - -
SP19: - - -

ExUns: 8g · 8h · 8i · 8j · 8k · 8l · 8m
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for NREP Gene

GeneLoc Exon Structure for
NREP
ECgene alternative splicing isoforms for
NREP

Expression for NREP Gene

mRNA expression in normal human tissues for NREP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NREP Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.0) and Brain - Cerebellum (x8.5).

SOURCE GeneReport for Unigene cluster for NREP Gene Hs.36053

mRNA Expression by UniProt/SwissProt for NREP Gene

Q16612-NREP_HUMAN
Tissue specificity: Expressed in lung (at protein level).
genes like me logo Genes that share expression patterns with NREP: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NREP Gene

Orthologs for NREP Gene

This gene was present in the common ancestor of chordates.

Orthologs for NREP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C10H5orf13 35
  • 88.73 (n)
  • 79.41 (a)
NREP 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NREP 35
  • 86.76 (n)
  • 75 (a)
NREP 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrep 35
  • 82.35 (n)
  • 76.47 (a)
Nrep 16
Nrep 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NREP 35
  • 99.51 (n)
  • 98.53 (a)
NREP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrep 35
  • 83.82 (n)
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7661 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.355 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4351 35
Species with no ortholog for NREP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NREP Gene

ENSEMBL:
Gene Tree for NREP (if available)
TreeFam:
Gene Tree for NREP (if available)

Paralogs for NREP Gene

(1) SIMAP similar genes for NREP Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NREP Gene

genes like me logo Genes that share paralogs with NREP: view

No data available for Paralogs for NREP Gene

Variants for NREP Gene

Sequence variations from dbSNP and Humsavar for NREP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_051238 -

Variation tolerance for NREP Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NREP Gene

HapMap Linkage Disequilibrium report
NREP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NREP Gene

Disorders for NREP Gene

Relevant External Links for NREP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NREP
genes like me logo Genes that share disorders with NREP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NREP Gene

Publications for NREP Gene

  1. P311 accelerates nerve regeneration of the axotomized facial nerve. (PMID: 15485502) Fujitani M. … Yamashita T. (J. Neurochem. 2004) 2 67
  2. P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype. (PMID: 12417574) Pan D. … Schuger L. (J. Clin. Invest. 2002) 23 67
  3. Transcriptional activation in chondrocytes submitted to hydrostatic pressure. (PMID: 10912181) Sironen R. … Lammi M.J. (Biorheology 2000) 23 67
  4. Metallothionein mediates gene expression of 3.1 mRNA (PTZ17) related to epileptic seizure. (PMID: 10981724) Miura N. … Naganuma A. (FEBS Lett. 2000) 2 67
  5. An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood. (PMID: 8261136) Studler J.M. … LAcvi-Strauss M. (Eur. J. Neurosci. 1993) 2 67

Products for NREP Gene

Sources for NREP Gene

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