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Aliases for NREP Gene

Aliases for NREP Gene

  • Neuronal Regeneration Related Protein 2 3 5
  • Neuronal Protein 3.1 2 3 4
  • Protein P311 3 4
  • C5orf13 3 4
  • P311 3 4
  • Neuronal Regeneration Related Protein Homolog (Rat) 2
  • Neuronal Regeneration Related Protein Homolog 3
  • Neuronal Regeneration-Related Protein 3
  • Chromosome 5 Open Reading Frame 13 2
  • PRO1873 3
  • D4S114 3
  • PTZ17 3
  • SEZ17 3

External Ids for NREP Gene

Previous HGNC Symbols for NREP Gene

  • C5orf13

Previous GeneCards Identifiers for NREP Gene

  • GC05M110999

Summaries for NREP Gene

GeneCards Summary for NREP Gene

NREP (Neuronal Regeneration Related Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NREP Gene

  • May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Gene Wiki entry for NREP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NREP Gene

Genomics for NREP Gene

Regulatory Elements for NREP Gene

Enhancers for NREP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NREP on UCSC Golden Path with GeneCards custom track

Genomic Location for NREP Gene

Chromosome:
5
Start:
111,662,621 bp from pter
End:
111,997,464 bp from pter
Size:
334,844 bases
Orientation:
Minus strand

Genomic View for NREP Gene

Genes around NREP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NREP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NREP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NREP Gene

Proteins for NREP Gene

  • Protein details for NREP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16612-NREP_HUMAN
    Recommended name:
    Neuronal regeneration-related protein
    Protein Accession:
    Q16612
    Secondary Accessions:
    • B2RDN8
    • B7Z5D2
    • D3DSZ8

    Protein attributes for NREP Gene

    Size:
    68 amino acids
    Molecular mass:
    7909 Da
    Quaternary structure:
    • Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction (By similarity). Interacts with FLNA.

    Alternative splice isoforms for NREP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NREP Gene

Post-translational modifications for NREP Gene

  • Phosphorylated on Ser-59. Phosphorylation decreases stability and activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for P311

No data available for DME Specific Peptides for NREP Gene

Domains & Families for NREP Gene

Protein Domains for NREP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NREP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NREP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NREP Gene

Function for NREP Gene

Molecular function for NREP Gene

UniProtKB/Swiss-Prot Function:
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in emphysematous lung compared to normal lung.

Gene Ontology (GO) - Molecular Function for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365962
genes like me logo Genes that share ontologies with NREP: view
genes like me logo Genes that share phenotypes with NREP: view

Animal Models for NREP Gene

MGI Knock Outs for NREP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NREP Gene

Localization for NREP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NREP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NREP Gene COMPARTMENTS Subcellular localization image for NREP gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NREP: view

Pathways & Interactions for NREP Gene

SuperPathways for NREP Gene

No Data Available

Gene Ontology (GO) - Biological Process for NREP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0031103 axon regeneration IEA --
GO:0045664 regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with NREP: view

No data available for Pathways by source and SIGNOR curated interactions for NREP Gene

Drugs & Compounds for NREP Gene

No Compound Related Data Available

Transcripts for NREP Gene

Unigene Clusters for NREP Gene

Neuronal regeneration related protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NREP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - -
SP15: - - - - -
SP16: - - - - - - - - -
SP17: - - - - - -
SP18: - - -
SP19: - - -

ExUns: 8g · 8h · 8i · 8j · 8k · 8l · 8m
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for NREP Gene

GeneLoc Exon Structure for
NREP
ECgene alternative splicing isoforms for
NREP

Expression for NREP Gene

mRNA expression in normal human tissues for NREP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NREP Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.0) and Brain - Cerebellum (x8.5).

NURSA nuclear receptor signaling pathways regulating expression of NREP Gene:

NREP

SOURCE GeneReport for Unigene cluster for NREP Gene:

Hs.36053

mRNA Expression by UniProt/SwissProt for NREP Gene:

Q16612-NREP_HUMAN
Tissue specificity: Expressed in lung (at protein level).
genes like me logo Genes that share expression patterns with NREP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NREP Gene

Orthologs for NREP Gene

This gene was present in the common ancestor of chordates.

Orthologs for NREP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C10H5orf13 34
  • 88.73 (n)
  • 79.41 (a)
NREP 35
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NREP 34
  • 86.76 (n)
  • 75 (a)
NREP 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrep 34
  • 82.35 (n)
  • 76.47 (a)
Nrep 16
Nrep 35
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NREP 34
  • 99.51 (n)
  • 98.53 (a)
NREP 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrep 34
  • 83.82 (n)
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7661 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.355 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4351 34
Species where no ortholog for NREP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NREP Gene

ENSEMBL:
Gene Tree for NREP (if available)
TreeFam:
Gene Tree for NREP (if available)

Paralogs for NREP Gene

(1) SIMAP similar genes for NREP Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NREP Gene

genes like me logo Genes that share paralogs with NREP: view

No data available for Paralogs for NREP Gene

Variants for NREP Gene

Sequence variations from dbSNP and Humsavar for NREP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_051238 -
rs166253 -- 111,778,682(+) TGTTT(G/T)TGTTT intron-variant
rs168869 -- 111,790,027(+) GCCAT(C/G)AAGTA intron-variant
rs168870 -- 111,789,929(+) TTTGA(C/T)ATGAA intron-variant
rs168871 -- 111,789,770(+) TTGGC(A/C)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NREP Gene

Variant ID Type Subtype PubMed ID
esv2730594 CNV deletion 23290073
esv3606277 CNV gain 21293372
esv3606278 CNV gain 21293372
esv3606280 CNV loss 21293372
esv3606281 CNV gain 21293372
nsv1073481 CNV deletion 25765185
nsv476416 CNV novel sequence insertion 20440878
nsv599367 CNV gain 21841781
nsv819569 CNV gain 19587683
nsv968233 CNV duplication 23825009
nsv968975 CNV duplication 23825009

Variation tolerance for NREP Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NREP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NREP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NREP Gene

Disorders for NREP Gene

Relevant External Links for NREP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NREP

No disorders were found for NREP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NREP Gene

Publications for NREP Gene

  1. Identification of P311 as a potential gene regulating alveolar generation. (PMID: 16484684) Zhao L. … Vu T.H. (Am. J. Respir. Cell Mol. Biol. 2006) 3 4 65
  2. Regulation of glioma cell migration by serine-phosphorylated P311. (PMID: 16229809) McDonough W.S. … Berens M.E. (Neoplasia 2005) 3 4 65
  3. P311 accelerates nerve regeneration of the axotomized facial nerve. (PMID: 15485502) Fujitani M. … Yamashita T. (J. Neurochem. 2004) 2 3 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for NREP Gene

Sources for NREP Gene

Content