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NREP Gene

protein-coding   GIFtS: 47
GCID: GC05M110999

Neuronal Regeneration Related Protein

(Previous names: chromosome 5 open reading frame 13, neuronal regeneration...)
(Previous symbol: C5orf13)
  Search for NREP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuronal Regeneration Related Protein1 2     Neuronal Regeneration Related Protein Homolog (Rat)1
C5orf131 2 3 5     D4S1142
Neuronal Protein 3.11 2 3     PRO18732
P3112 3 5     SEZ172
Protein P3112 3     Neuronal Regeneration Related Protein Homolog2
PTZ172 5     Neuronal Regeneration-Related Protein2
Chromosome 5 Open Reading Frame 131     

External Ids:    HGNC: 168341   Entrez Gene: 93152   Ensembl: ENSG000001349867   OMIM: 6073325   UniProtKB: Q166123   

Export aliases for NREP gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NREP Gene:
NREP (neuronal regeneration related protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: NREP_HUMAN, Q16612
Function: May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal
regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces
differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid
regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not
of TGFB3 (By similarity). May play a role in the regulation of alveolar generation

Gene Wiki entry for NREP (C5orf13) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NREP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNREP promoter sequence
   Search Chromatin IP Primers for NREP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NREP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.1   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22.1

NREP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NREP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M110999:  view genomic region     (about GC identifiers)

Start:
110,998,318 bp from pter      End:
111,333,161 bp from pter
Size:
334,844 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NREP_HUMAN, Q16612 (See protein sequence)
Recommended Name: Neuronal regeneration-related protein  
Size: 68 amino acids; 7909 Da
Subunit: Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a
decrease in TGFB autoinduction (By similarity). Interacts with FLNA
Developmental stage: In embryos of gestational week (gw) 24, detected mostly in the epithelial cells of saccular
surfaces. In gw 39, detected in the cells lining the alveolar surfaces as well as in the mesenchyme (at protein
level)
Secondary accessions: B2RDN8 B7Z5D2 D3DSZ8
Alternative splicing: 2 isoforms:  Q16612-1   Q16612-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NREP: NX_Q16612

Explore proteomics data for NREP at MOPED

Post-translational modifications: 

  • Phosphorylated on Ser-59. Phosphorylation decreases stability and activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NREP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (11 alternative transcripts): 
    NP_001135946.1  NP_001135947.1  NP_001135948.1  NP_001135949.1  NP_001135950.1  NP_001135951.1  NP_001135952.1  NP_001135953.1  
    NP_001135954.1  NP_001135955.1  NP_004763.1  

    ENSEMBL proteins: 
     ENSP00000427595   ENSP00000426834   ENSP00000368993   ENSP00000257435   ENSP00000402965  
     ENSP00000378996   ENSP00000422278   ENSP00000423320   ENSP00000416617   ENSP00000399766  
     ENSP00000422630   ENSP00000403383   ENSP00000392559   ENSP00000427149   ENSP00000427476  
     ENSP00000422046   ENSP00000422514   ENSP00000408839  

    NREP Human Recombinant Protein Products:

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    Novus Biologicals NREP Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NREP 

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for NREP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024417 Neuronal_3.1

    Graphical View of Domain Structure for InterPro Entry Q16612

    ProtoNet protein and cluster: Q16612


    Find genes that share domains with NREP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NREP_HUMAN, Q16612
    Function: May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal
    regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces
    differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid
    regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not
    of TGFB3 (By similarity). May play a role in the regulation of alveolar generation
    Induction: Down-regulated in emphysematous lung compared to normal lung

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with NREP           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NREP:
     Increased gamma-H2AX phosphory  Large nuclei 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nrep):
     behavior/neurological 

    Find genes that share phenotypes with NREP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nreptm1Wcw for NREP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NREP
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NREP

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    hsa-mir-29b-3p (MIRT048382), hsa-mir-98-5p (MIRT027728), hsa-mir-215-5p (MIRT024413), hsa-mir-192-5p (MIRT026664)

    Block miRNA regulation of human, mouse, rat NREP using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NREP_HUMAN, Q16612: Cytoplasm

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with NREP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NREP
    Interactions:

        Search GeneGlobe Interaction Network for NREP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for NREP (Q166121, 2, 3 ENSP000004033834) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000272333Q9UMN62, 3, ENSP000002222704MINT-8249964 I2D: score=2 STRING: ENSP00000222270
    KMT2BQ9UMN62, 3MINT-8249964 I2D: score=2 
    EEF1A1P681042, 3MINT-8249953 I2D: score=2 
    IGSF21Q96ID52, 3, ENSP000002512964MINT-64285 I2D: score=4 STRING: ENSP00000251296
    EIF6P565371EBI-718657,EBI-372243
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017015regulation of transforming growth factor beta receptor signaling pathway IEA--
    GO:0031103axon regeneration IEA--
    GO:0045664regulation of neuron differentiation IEA--

    Find genes that share ontologies with NREP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NREP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NREP gene (11 alternative transcripts): 
    NM_001142474.1  NM_001142475.1  NM_001142476.1  NM_001142477.1  NM_001142478.1  NM_001142479.1  NM_001142480.1  NM_001142481.1  
    NM_001142482.1  NM_001142483.1  NM_004772.2  

    Unigene Cluster for NREP:

    Neuronal regeneration related protein
    Hs.36053  [show with all ESTs]
    Unigene Representative Sequence: NM_001142483
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000514515(uc003kpk.3) ENST00000509025 ENST00000379671(uc011cvo.2)
    ENST00000257435(uc003kpm.3 uc011cvp.2 uc011cvq.2 uc011cvr.2 uc011cvs.2)
    ENST00000446294(uc011cvk.2 uc011cvl.2 uc011cvm.2 uc011cvn.2)
    ENST00000395634 ENST00000515855 ENST00000507742 ENST00000509979 ENST00000450761
    ENST00000419114 ENST00000509427 ENST00000453526 ENST00000455559 ENST00000508870
    ENST00000513100 ENST00000504018 ENST00000508161
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NREP
      QuantiFast Probe-based Assays in human, mouse, rat NREP

    Additional mRNA sequence: 

    AF119859.1 AK298779.1 AK307346.1 AK309667.1 AK310585.1 AK315617.1 BC011050.1 BC019068.2 
    BC072013.1 BC072443.1 U30521.1 U36189.1 

    Selected DOTS entries (see all 46):

    DT.100846375  DT.95080590  DT.420637  DT.100846383  DT.100846378  DT.100846365  DT.101974074  DT.92461153 
    DT.121468359  DT.100730958  DT.100659343  DT.100766891  DT.100809932  DT.97841224  DT.87015645  DT.207399 
    DT.95080645  DT.120846838  DT.100772303  DT.100846382  DT.99981881  DT.120846737  DT.100846374  DT.120846766 

    Selected AceView cDNA sequences (see all 804):

    BM876293 BM759797 AA358206 AA332487 AA311684 AI432016 CR594948 CR590608 
    BX386605 AI753231 BC072443 T33579 BM475627 BE766462 BE552319 AI923288 
    AA082723 T33349 BU172481 AA452615 AA186849 AI937061 CR605504 AA732794 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NREP (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ·
    SP1:                          -     -     -     -     -     -     -     -           -     -                 -     -                                             
    SP2:                          -     -     -     -     -     -     -     -           -     -                 -     -     -                                       
    SP3:                                -     -     -     -     -     -     -           -     -                 -     -     -                                       
    SP4:                                -     -     -     -     -     -     -           -                       -     -     -                                       
    SP5:                          -     -     -     -     -     -     -     -           -     -                 -     -     -                                       

    ExUns: 8g · 8h · 8i · 8j · 8k · 8l · 8m
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for NREP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NREP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAGTACCC
    NREP Expression
    About this image


    NREP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             N2/LSB/S/F8/CHIR-induced cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    NREP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NREP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.36053

    UniProtKB/Swiss-Prot: NREP_HUMAN, Q16612
    Tissue specificity: Expressed in lung (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NREP gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrep1 , 5 DNA segment, human D4S1145
    neuronal regeneration related protein1
    82.35(n)1
    76.47(a)1
      18 (18.18 cM)5
    275281  NM_001109988.11  NP_001103458.11 
     334370195 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.3552 Xenopus laevis gene 12-3 mRNA 83.38(n)    U41854.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570441002   -- 82.65(n)    57044100 


    ENSEMBL Gene Tree for NREP (if available)
    TreeFam Gene Tree for NREP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NREP gene
    1 SIMAP similar gene for NREP using alignment to 5 protein entries:     NREP_HUMAN (see all proteins):
    LOC392642

    Find genes that share paralogs with NREP           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NREP
    PGOHUM00000233149 PGOHUM00000249663


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NREP (see all 3457)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37339941,2
    C--106271941(+) GCGCGA/CGCGCC 2 -- int10--------
    rs1423872591,2
    --106271958(+) CCCCGC/TACCCG 2 -- int10--------
    rs1876147021,2
    --106272068(+) GGAGCA/GCGGCG 2 -- int10--------
    rs2018980381,2
    --106272081(+) GCAAA-/TTCCCC 2 -- int10--------
    rs1931773421,2
    --106272399(+) ACACAA/CAGAGT 2 -- int10--------
    rs789653861,2
    C,F--106272413(+) CGAAGG/CATGCA 2 -- int13Minor allele frequency- C:0.21CSA WA 121
    rs1513068371,2
    --106272609(+) GTGATC/GGGCCC 2 -- int10--------
    rs1405945781,2
    C--106272610(+) TGATCA/GGCCCA 2 -- int10--------
    rs2015344831,2
    --106272692(+) TTTTT-/AAAAAT 2 -- int10--------
    rs65945351,2
    C,F,A--106272704(+) GAGGAT/CTGCTT 2 -- int16Minor allele frequency- C:0.20NA WA 246

    HapMap Linkage Disequilibrium report for NREP (110998318 - 111248318 bp, first 250kb of NREP)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NREP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NREP
    DNA2.0 Custom Variant and Variant Library Synthesis for NREP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607332    OMIM disorders: --


    Find genes that share disorders with NREP           About GenesLikeMe


    Export disorders for NREP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NREP gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with NREP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of P311 as a potential gene regulating alveolar generation. (PubMed id 16484684)1, 2 Zhao L.... Vu T.H. (Am. J. Respir. Cell Mol. Biol. 2006)
    2. Regulation of glioma cell migration by serine-phosphorylated P311. (PubMed id 16229809)1, 2 McDonough W.S.... Berens M.E. (Neoplasia 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. P311 accelerates nerve regeneration of the axotomized facial nerve. (PubMed id 15485502)1, 3 Fujitani M....Yamashita T. (J. Neurochem. 2004)
    6. Metallothionein mediates gene expression of 3.1 mRNA (PTZ17) related to epileptic seizure. (PubMed id 10981724)1, 3 Miura N. and Naganuma A. (FEBS Lett. 2000)
    7. An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood. (PubMed id 8261136)1, 3 Studler J.M....LAcvi-Strauss M. (Eur. J. Neurosci. 1993)
    8. P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype. (PubMed id 12417574)1, 9 Pan D....Schuger L. (J. Clin. Invest. 2002)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. [Effects of P 311 on the migration of epidermal stem cells in mice with superficial partial-thickness burn and injured cell model in vitro]. (PubMed id 22967977)1 Sun W....Luo G.X. (Zhonghua Shao Shang Za Zhi 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9315 HGNC: 16834 AceView: C5orf13 Ensembl:ENSG00000134986 euGenes: HUgn9315
    ECgene: NREP H-InvDB: NREP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NREP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NREP gene:
    Search GeneIP for patents involving NREP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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