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Aliases for NRDE2 Gene

Aliases for NRDE2 Gene

  • NRDE-2, Necessary For RNA Interference, Domain Containing 2 3 5
  • C14orf102 3 4
  • Chromosome 14 Open Reading Frame 102 2
  • UPF0614 Protein C14orf102 3
  • Protein NRDE2 Homolog 3

External Ids for NRDE2 Gene

Previous HGNC Symbols for NRDE2 Gene

  • C14orf102

Previous GeneCards Identifiers for NRDE2 Gene

  • GC14M090742
  • GC14M090296
  • GC14M090328
  • GC14M090596

Summaries for NRDE2 Gene

GeneCards Summary for NRDE2 Gene

NRDE2 (NRDE-2, Necessary For RNA Interference, Domain Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRDE2 Gene

Genomics for NRDE2 Gene

Regulatory Elements for NRDE2 Gene

Enhancers for NRDE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NRDE2 on UCSC Golden Path with GeneCards custom track

Promoters for NRDE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRDE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRDE2 Gene

Chromosome:
14
Start:
90,267,856 bp from pter
End:
90,332,137 bp from pter
Size:
64,282 bases
Orientation:
Minus strand

Genomic View for NRDE2 Gene

Genes around NRDE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRDE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRDE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRDE2 Gene

Proteins for NRDE2 Gene

  • Protein details for NRDE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7Z3-NRDE2_HUMAN
    Recommended name:
    Protein NRDE2 homolog
    Protein Accession:
    Q9H7Z3
    Secondary Accessions:
    • B4DH71
    • Q4G0A7
    • Q9NWH6

    Protein attributes for NRDE2 Gene

    Size:
    1164 amino acids
    Molecular mass:
    132673 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NRDE2 Gene

Post-translational modifications for NRDE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRDE2 Gene

No data available for DME Specific Peptides for NRDE2 Gene

Domains & Families for NRDE2 Gene

Protein Domains for NRDE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRDE2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H7Z3

UniProtKB/Swiss-Prot:

NRDE2_HUMAN :
  • Belongs to the NRDE2 family.
  • Contains 5 HAT repeats.
Family:
  • Belongs to the NRDE2 family.
Similarity:
  • Contains 5 HAT repeats.
genes like me logo Genes that share domains with NRDE2: view

No data available for Gene Families for NRDE2 Gene

Function for NRDE2 Gene

Gene Ontology (GO) - Molecular Function for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NRDE2: view
genes like me logo Genes that share phenotypes with NRDE2: view

Animal Models for NRDE2 Gene

MGI Knock Outs for NRDE2:

Animal Model Products

CRISPR Products

miRNA for NRDE2 Gene

miRTarBase miRNAs that target NRDE2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRDE2 Gene

Localization for NRDE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRDE2 Gene COMPARTMENTS Subcellular localization image for NRDE2 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with NRDE2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NRDE2 Gene

Pathways & Interactions for NRDE2 Gene

SuperPathways for NRDE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016246 RNA interference IBA --
GO:0031048 chromatin silencing by small RNA IBA --
genes like me logo Genes that share ontologies with NRDE2: view

No data available for Pathways by source and SIGNOR curated interactions for NRDE2 Gene

Drugs & Compounds for NRDE2 Gene

No Compound Related Data Available

Transcripts for NRDE2 Gene

Unigene Clusters for NRDE2 Gene

NRDE-2, necessary for RNA interference, domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRDE2 Gene

No ASD Table

Relevant External Links for NRDE2 Gene

GeneLoc Exon Structure for
NRDE2
ECgene alternative splicing isoforms for
NRDE2

Expression for NRDE2 Gene

mRNA expression in normal human tissues for NRDE2 Gene

Protein differential expression in normal tissues from HIPED for NRDE2 Gene

This gene is overexpressed in Heart (16.0), Lung (12.7), Neutrophil (9.1), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRDE2 Gene



Protein tissue co-expression partners for NRDE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRDE2 Gene:

NRDE2

SOURCE GeneReport for Unigene cluster for NRDE2 Gene:

Hs.528131
genes like me logo Genes that share expression patterns with NRDE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NRDE2 Gene

Orthologs for NRDE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NRDE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRDE2 34
  • 81.52 (n)
  • 80.44 (a)
NRDE2 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRDE2 34
  • 82.87 (n)
  • 82.37 (a)
NRDE2 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrde2 34
  • 82.43 (n)
  • 80.7 (a)
Nrde2 16
Nrde2 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRDE2 34
  • 99.63 (n)
  • 99.66 (a)
NRDE2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrde2 34
  • 82.68 (n)
  • 80.94 (a)
oppossum
(Monodelphis domestica)
Mammalia NRDE2 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRDE2 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF102 34
  • 67.61 (n)
  • 64.05 (a)
NRDE2 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRDE2 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrde2 34
  • 60.77 (n)
  • 57.77 (a)
Str.19178 34
zebrafish
(Danio rerio)
Actinopterygii Dr.29156 34
LOC794348 34
  • 56.36 (n)
  • 51.07 (a)
nrde2 35
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4429 34
worm
(Caenorhabditis elegans)
Secernentea nrde-2 35
  • 14 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G17712 34
  • 44.9 (n)
  • 32.05 (a)
rice
(Oryza sativa)
Liliopsida Os02g0772500 34
  • 41.55 (n)
  • 29.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
-- 35
  • 29 (a)
OneToMany
Species where no ortholog for NRDE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRDE2 Gene

ENSEMBL:
Gene Tree for NRDE2 (if available)
TreeFam:
Gene Tree for NRDE2 (if available)

Paralogs for NRDE2 Gene

(2) SIMAP similar genes for NRDE2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NRDE2: view

No data available for Paralogs for NRDE2 Gene

Variants for NRDE2 Gene

Sequence variations from dbSNP and Humsavar for NRDE2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7140914 - 90,318,083(+) CAACA(A/C/T)AAAAG reference, missense
rs3737035 - 90,279,078(+) GGCAA(C/T)TCTGA reference, missense
rs59039343 - 90,288,593(+) CTGTT(C/T)GTATA reference, missense
rs10184 -- 90,278,328(-) AGCAG(C/T)GGGAA utr-variant-3-prime
rs2401882 -- 90,314,629(+) AGAAG(G/T)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRDE2 Gene

Variant ID Type Subtype PubMed ID
esv2652044 CNV insertion 19546169
esv2749005 CNV deletion 23290073
esv3383627 CNV duplication 20981092
esv3581385 CNV loss 25503493

Variation tolerance for NRDE2 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRDE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRDE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRDE2 Gene

Disorders for NRDE2 Gene

Relevant External Links for NRDE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRDE2

No disorders were found for NRDE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRDE2 Gene

Publications for NRDE2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 65
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 65

Products for NRDE2 Gene

Sources for NRDE2 Gene

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