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Aliases for NRDE2 Gene

Aliases for NRDE2 Gene

  • NRDE-2, Necessary For RNA Interference, Domain Containing 2 3 5
  • C14orf102 3 4
  • Chromosome 14 Open Reading Frame 102 2
  • UPF0614 Protein C14orf102 3
  • Protein NRDE2 Homolog 3

External Ids for NRDE2 Gene

Previous HGNC Symbols for NRDE2 Gene

  • C14orf102

Previous GeneCards Identifiers for NRDE2 Gene

  • GC14M090742
  • GC14M090296
  • GC14M090328
  • GC14M090596
  • GC14M090602
  • GC14M090821

Summaries for NRDE2 Gene

GeneCards Summary for NRDE2 Gene

NRDE2 (NRDE-2, Necessary For RNA Interference, Domain Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRDE2 Gene

Genomics for NRDE2 Gene

Regulatory Elements for NRDE2 Gene

Enhancers for NRDE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G090300 1.4 Ensembl ENCODE dbSUPER 18.1 +28.9 28896 5.3 FOXA2 MLX ARID4B RAD21 RARA YY1 ELK1 GATA2 ZNF366 PCBP1 NRDE2 CALM1 RPS18P2 KCNK13 PIR47953 PIR41665
GH14G090298 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +32.7 32716 1.8 ZNF316 MAFG MAX NFE2 EMSY MYC MAFK NRDE2 CALM1 KCNK13 PIR41665 PIR47953
GH14G090555 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -224.3 -224295 1.8 PKNOX1 ZBTB40 RELB USF2 JUNB ZEB2 REST TBX21 RAD51 NBN NRDE2 ENSG00000258875 CALM1 TTC7B GC14M091542 LOC105370620
GH14G090407 1.4 Ensembl ENCODE dbSUPER 10.3 -77.0 -76999 2.7 INSM2 KLF17 ZNF2 ZNF366 ZSCAN5C FOS ZNF391 EGR2 SP3 ZNF362 NRDE2 ENSG00000258424 LINC02317
GH14G090273 1.2 Ensembl ENCODE dbSUPER 11.3 +56.6 56557 3.2 CTCF ZIC2 YY1 SREBF1 ZFHX2 ZNF366 POLR2A SMARCA4 SCRT2 HNF4A NRDE2 KCNK13 PIR51620 GC14M091550
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRDE2 on UCSC Golden Path with GeneCards custom track

Promoters for NRDE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000071943 237 1400 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF207

Genomic Location for NRDE2 Gene

90,267,856 bp from pter
90,332,137 bp from pter
64,282 bases
Minus strand

Genomic View for NRDE2 Gene

Genes around NRDE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRDE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRDE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRDE2 Gene

Proteins for NRDE2 Gene

  • Protein details for NRDE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NRDE2 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DH71
    • Q4G0A7
    • Q9NWH6

    Protein attributes for NRDE2 Gene

    1164 amino acids
    Molecular mass:
    132673 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NRDE2 Gene

Post-translational modifications for NRDE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NRDE2 Gene

Domains & Families for NRDE2 Gene

Protein Domains for NRDE2 Gene

Suggested Antigen Peptide Sequences for NRDE2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NRDE2 family.
  • Belongs to the NRDE2 family.
genes like me logo Genes that share domains with NRDE2: view

No data available for Gene Families for NRDE2 Gene

Function for NRDE2 Gene

Gene Ontology (GO) - Molecular Function for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NRDE2: view
genes like me logo Genes that share phenotypes with NRDE2: view

Animal Models for NRDE2 Gene

MGI Knock Outs for NRDE2:

Animal Model Products

CRISPR Products

miRNA for NRDE2 Gene

miRTarBase miRNAs that target NRDE2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRDE2 Gene

Localization for NRDE2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRDE2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with NRDE2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NRDE2 Gene

Pathways & Interactions for NRDE2 Gene

SuperPathways for NRDE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016246 RNA interference IBA --
GO:0031048 chromatin silencing by small RNA IBA --
genes like me logo Genes that share ontologies with NRDE2: view

No data available for Pathways by source and SIGNOR curated interactions for NRDE2 Gene

Drugs & Compounds for NRDE2 Gene

No Compound Related Data Available

Transcripts for NRDE2 Gene

Unigene Clusters for NRDE2 Gene

NRDE-2, necessary for RNA interference, domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRDE2 Gene

No ASD Table

Relevant External Links for NRDE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRDE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRDE2 Gene

Protein differential expression in normal tissues from HIPED for NRDE2 Gene

This gene is overexpressed in Heart (16.0), Lung (12.7), Neutrophil (9.1), and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRDE2 Gene

Protein tissue co-expression partners for NRDE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRDE2 Gene:


SOURCE GeneReport for Unigene cluster for NRDE2 Gene:


Evidence on tissue expression from TISSUES for NRDE2 Gene

  • Nervous system(4.2)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with NRDE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRDE2 Gene

Orthologs for NRDE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NRDE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NRDE2 35 34
  • 99.63 (n)
(Canis familiaris)
Mammalia NRDE2 35 34
  • 82.87 (n)
(Rattus norvegicus)
Mammalia Nrde2 34
  • 82.68 (n)
(Mus musculus)
Mammalia Nrde2 16 35 34
  • 82.43 (n)
(Bos Taurus)
Mammalia NRDE2 35 34
  • 81.52 (n)
(Ornithorhynchus anatinus)
Mammalia NRDE2 35
  • 74 (a)
(Monodelphis domestica)
Mammalia NRDE2 35
  • 72 (a)
(Gallus gallus)
Aves C5H14ORF102 34
  • 67.61 (n)
NRDE2 35
  • 62 (a)
(Anolis carolinensis)
Reptilia NRDE2 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nrde2 34
  • 60.77 (n)
Str.19178 34
(Danio rerio)
Actinopterygii LOC794348 34
  • 56.36 (n)
nrde2 35
  • 48 (a)
Dr.29156 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4429 34
(Caenorhabditis elegans)
Secernentea nrde-2 35
  • 14 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G17712 34
  • 44.9 (n)
(Oryza sativa)
Liliopsida Os02g0772500 34
  • 41.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
-- 35
  • 29 (a)
Species where no ortholog for NRDE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRDE2 Gene

Gene Tree for NRDE2 (if available)
Gene Tree for NRDE2 (if available)

Paralogs for NRDE2 Gene

(2) SIMAP similar genes for NRDE2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NRDE2: view

No data available for Paralogs for NRDE2 Gene

Variants for NRDE2 Gene

Sequence variations from dbSNP and Humsavar for NRDE2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000042076 -- 90,275,683(+) GAAGT(C/G)CTTGT intron-variant
rs1000080683 -- 90,332,311(+) TAAGC(A/G/T)TTACT upstream-variant-2KB
rs1000120464 -- 90,294,256(+) CCTGC(A/T)GGTGG intron-variant
rs1000134832 -- 90,291,265(+) TGCTT(A/G)TCTGA intron-variant
rs1000210662 -- 90,308,972(+) GCGTG(A/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRDE2 Gene

Variant ID Type Subtype PubMed ID
esv2652044 CNV insertion 19546169
esv2749005 CNV deletion 23290073
esv3383627 CNV duplication 20981092
esv3581385 CNV loss 25503493

Variation tolerance for NRDE2 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRDE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRDE2 Gene

Disorders for NRDE2 Gene

Relevant External Links for NRDE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NRDE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRDE2 Gene

Publications for NRDE2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 64

Products for NRDE2 Gene

Sources for NRDE2 Gene

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