Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NRDE2 Gene

Aliases for NRDE2 Gene

  • NRDE-2, Necessary For RNA Interference, Domain Containing 2 3
  • C14orf102 3 4
  • Chromosome 14 Open Reading Frame 102 2
  • UPF0614 Protein C14orf102 3
  • Protein NRDE2 Homolog 3

External Ids for NRDE2 Gene

Previous HGNC Symbols for NRDE2 Gene

  • C14orf102

Previous GeneCards Identifiers for NRDE2 Gene

  • GC14M090742

Summaries for NRDE2 Gene

GeneCards Summary for NRDE2 Gene

NRDE2 (NRDE-2, Necessary For RNA Interference, Domain Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRDE2 Gene

Genomics for NRDE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NRDE2 Gene

90,267,856 bp from pter
90,332,137 bp from pter
64,282 bases
Minus strand

Genomic View for NRDE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRDE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRDE2 Gene

No data available for Regulatory Elements for NRDE2 Gene

Proteins for NRDE2 Gene

  • Protein details for NRDE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NRDE2 homolog
    Protein Accession:
    Secondary Accessions:
    • B4DH71
    • Q4G0A7
    • Q9NWH6

    Protein attributes for NRDE2 Gene

    1164 amino acids
    Molecular mass:
    132673 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NRDE2 Gene

Proteomics data for NRDE2 Gene at MOPED

Post-translational modifications for NRDE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRDE2 Gene

No data available for DME Specific Peptides for NRDE2 Gene

Domains for NRDE2 Gene

Protein Domains for NRDE2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9H7Z3
  • Belongs to the NRDE2 family.
  • Contains 5 HAT repeats.
genes like me logo Genes that share domains with NRDE2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NRDE2 Gene

Function for NRDE2 Gene

Gene Ontology (GO) - Molecular Function for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NRDE2: view

Phenotypes for NRDE2 Gene

genes like me logo Genes that share phenotypes with NRDE2: view

Animal Model Products

CRISPR Products

miRNA for NRDE2 Gene

miRTarBase miRNAs that target NRDE2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NRDE2 Gene

Localization for NRDE2 Gene

Gene Ontology (GO) - Cellular Components for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with NRDE2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NRDE2 Gene

Pathways for NRDE2 Gene

SuperPathways for NRDE2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRDE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRDE2: view

No data available for Pathways by source for NRDE2 Gene

Transcripts for NRDE2 Gene

Unigene Clusters for NRDE2 Gene

NRDE-2, necessary for RNA interference, domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRDE2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NRDE2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRDE2 Gene

No ASD Table

Relevant External Links for NRDE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRDE2 Gene

mRNA expression in normal human tissues for NRDE2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRDE2 Gene

SOURCE GeneReport for Unigene cluster for NRDE2 Gene Hs.528131

genes like me logo Genes that share expressions with NRDE2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NRDE2 Gene

Orthologs for NRDE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NRDE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NRDE2 35
  • 99.63 (n)
  • 99.66 (a)
NRDE2 36
  • 100 (a)
(Bos Taurus)
Mammalia NRDE2 35
  • 81.52 (n)
  • 80.44 (a)
NRDE2 36
  • 80 (a)
(Canis familiaris)
Mammalia NRDE2 35
  • 82.87 (n)
  • 82.37 (a)
NRDE2 36
  • 81 (a)
(Mus musculus)
Mammalia Nrde2 35
  • 82.43 (n)
  • 80.7 (a)
Nrde2 16
Nrde2 36
  • 80 (a)
(Monodelphis domestica)
Mammalia NRDE2 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NRDE2 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Nrde2 35
  • 82.68 (n)
  • 80.94 (a)
(Gallus gallus)
Aves C5H14ORF102 35
  • 67.61 (n)
  • 64.05 (a)
NRDE2 36
  • 62 (a)
(Anolis carolinensis)
Reptilia NRDE2 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nrde2 35
  • 60.77 (n)
  • 57.77 (a)
Str.19178 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4429 35
(Danio rerio)
Actinopterygii Dr.29156 35
LOC794348 35
  • 56.36 (n)
  • 51.07 (a)
nrde2 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea nrde-2 36
  • 14 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G17712 35
  • 44.9 (n)
  • 32.05 (a)
(Oryza sativa)
Liliopsida Os02g0772500 35
  • 41.55 (n)
  • 29.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
-- 36
  • 29 (a)
Species with no ortholog for NRDE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRDE2 Gene

Gene Tree for NRDE2 (if available)
Gene Tree for NRDE2 (if available)

Paralogs for NRDE2 Gene

Selected SIMAP similar genes for NRDE2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NRDE2: view

No data available for Paralogs for NRDE2 Gene

Variants for NRDE2 Gene

Sequence variations from dbSNP and Humsavar for NRDE2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10184 -- 90,278,328(-) AGCAG(C/T)GGGAA utr-variant-3-prime
rs716122 -- 90,325,969(-) AAATG(G/T)AAAAT intron-variant
rs943986 -- 90,307,373(+) AGGCT(A/G)TAATT intron-variant
rs1952476 -- 90,298,821(+) CTAGT(A/G)TCACT intron-variant
rs2094653 -- 90,318,483(+) ATTTG(A/G)TTCAG intron-variant

Relevant External Links for NRDE2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NRDE2 Gene

Disorders for NRDE2 Gene

No disorders were found for NRDE2 Gene.

No data available for UniProtKB/Swiss-Prot for NRDE2 Gene

Publications for NRDE2 Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  4. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for NRDE2 Gene

Sources for NRDE2 Gene

Back to Top