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NRDE2 Gene

protein-coding   GIFtS: 38
GCID: GC14M090742

NRDE-2, Necessary For RNA Interference, Domain Containing

(Previous name: chromosome 14 open reading frame 102)
(Previous symbol: C14orf102)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NRDE-2, Necessary For RNA Interference, Domain Containing1 2
C14orf1021 2 3
Chromosome 14 Open Reading Frame 1021
Protein NRDE2 Homolog2
UPF0614 Protein C14orf1022

External Ids:    HGNC: 201861   Entrez Gene: 550512   Ensembl: ENSG000001197207   UniProtKB: Q9H7Z33   

Export aliases for NRDE2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NRDE2 Gene:
NRDE2 (NRDE-2, necessary for RNA interference, domain containing) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NRDE2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NRDE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRDE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.11   Ensembl cytogenetic band:  14q32.11   HGNC cytogenetic band: 14q32.11

NRDE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRDE2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M090742:  view genomic region     (about GC identifiers)

Start:
90,742,580 bp from pter      End:
90,798,481 bp from pter
Size:
55,902 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NRDE2_HUMAN, Q9H7Z3 (See protein sequence)
Recommended Name: Protein NRDE2 homolog  
Size: 1164 amino acids; 132673 Da
Sequence caution: Sequence=BAB14830.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DH71 Q4G0A7 Q9NWH6

Explore the universe of human proteins at neXtProt for NRDE2: NX_Q9H7Z3

Explore proteomics data for NRDE2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NRDE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060440.2  
    ENSEMBL proteins: 
     ENSP00000346335   ENSP00000452107   ENSP00000451025   ENSP00000452071   ENSP00000350579  

    NRDE2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search antibodies-online for peptides for NRDE2

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    Search eBioscience for ELISAs for NRDE2 
    antibodies-online kits for NRDE2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013633 NRDE-2

    Graphical View of Domain Structure for InterPro Entry Q9H7Z3

    ProtoNet protein and cluster: Q9H7Z3

    UniProtKB/Swiss-Prot: NRDE2_HUMAN, Q9H7Z3
    Similarity: Belongs to the NRDE2 family
    Similarity: Contains 5 HAT repeats


    Find genes that share domains with NRDE2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with NRDE2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NRDE2:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nrde2):
     mortality/aging 

    Find genes that share phenotypes with NRDE2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NRDE2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NRDE2:
    hsa-mir-149-5p (MIRT045459), hsa-mir-196a-5p (MIRT048282)

    Block miRNA regulation of human, mouse, rat NRDE2 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidNRDE2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with NRDE2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRDE2
    Interactions:

        Search GeneGlobe Interaction Network for NRDE2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NRDE2 (Q9H7Z31, 3 ENSP000003463354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNPS1Q152871, 3, ENSP000003158594EBI-1042642,EBI-395959 I2D: score=2 STRING: ENSP00000315859
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with NRDE2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRDE2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NRDE2 gene (2 alternative transcripts): 
    NM_199043.1  NM_017970.3  

    Unigene Cluster for NRDE2:

    NRDE-2, necessary for RNA interference, domain containing
    Hs.528131  [show with all ESTs]
    Unigene Representative Sequence: AK024113
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354366(uc001xyi.2 uc001xyj.2) ENST00000556189 ENST00000553409
    ENST00000557732 ENST00000555903 ENST00000554464 ENST00000557064 ENST00000557106
    ENST00000357904(uc010atp.1)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidNRDE2 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NRDE2
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      QuantiTect SYBR Green Assays in human, mouse, rat NRDE2
      QuantiFast Probe-based Assays in human, mouse, rat NRDE2

    Additional mRNA sequence: 

    AK000870.1 AK024113.1 AK294958.1 AL832941.1 BC008925.2 BC021805.1 BC033136.1 BC098568.1 
    BC109040.1 BC118673.1 BC122532.1 

    10 DOTS entries:

    DT.101981959  DT.443671  DT.70105514  DT.120770965  DT.100698094  DT.40129789  DT.432730  DT.99990684 
    DT.100695417  DT.120770920 

    Selected AceView cDNA sequences (see all 125):

    AI536956 CR605863 BE672432 AI660721 CA454690 AW003217 AI348282 AI279810 
    CB850562 F24734 NM_199043 BU608177 NM_017970 BF593438 BE466430 CA309475 
    BE326856 AA477624 AW090761 BX281786 BU194109 BC008925 BP351002 AA346979 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRDE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NRDE2 Expression
    About this image

    NRDE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRDE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528131
        Custom PCR Arrays for NRDE2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRDE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NRDE2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrde21 , 5 cDNA sequence BC0022305
    nrde-2 necessary for RNA interference, domain containing1
    82.43(n)1
    80.7(a)1
      12 (50.43 cM)5
    2178271  NM_183155.21  NP_898978.21 
     1001254525 
    chicken
    (Gallus gallus)
    Aves C5H14ORF1021 chromosome 5 open reading frame, human C14orf102 67.61(n)
    64.05(a)
      423404  XM_421314.4  XP_421314.3 
    lizard
    (Anolis carolinensis)
    Reptilia NRDE26
    NRDE-2, necessary for RNA interference, domain con...
    58(a)
    1 ↔ 1
    1(12599842-12633452)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.191782 Transcribed sequence with weak similarity to protein more 70.86(n)    AL846978.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.291562 Transcribed sequence with moderate similarity to protein more 74.32(n)    BQ261152.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nrde-26
    Protein NRDE-2 (nrde-2) mRNA, complete cds
    14(a)
    1 ↔ 1
    II(10242593-10247638) WBGene00011333
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G177121 AT3G17712 44.9(n)
    32.05(a)
      7922332  NM_001161148.1  NP_001154620.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07725001 Os02g0772500 41.55(n)
    29.67(a)
      4330879  NM_001054800.1  NP_001048265.1 


    ENSEMBL Gene Tree for NRDE2 (if available)
    TreeFam Gene Tree for NRDE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRDE2 gene
    2 SIMAP similar genes for NRDE2 using alignment to 5 protein entries:     NRDE2_HUMAN (see all proteins):
    DKFZp666I2110    C14orf102

    Find genes that share paralogs with NRDE2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRDE2 (see all 1275)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005421501,2
    Cuntested190756870(+) GAACTA/GCAGGA 2 Q * stg10--------
    rs116210071,2
    C,F,H--90743967(+) ACAGCG/ATGCTC 1 -- int110Minor allele frequency- A:0.17NS EA NA CSA WA 764
    rs284075311,2
    C,F--90743973(+) TGCTCG/AGCTCC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1394478151,2
    --90744037(+) TTCCAA/CACTCA 1 -- int10--------
    rs286124751,2
    C--90744057(+) GGACCC/TGCTGA 1 -- int10--------
    rs1864054731,2
    --90744067(+) AAGAGC/TGGGTT 1 -- int10--------
    rs789676881,2
    C,F--90744132(+) CTCCAG/CGCGGA 1 -- int12Minor allele frequency- C:0.10WA 120
    rs171266411,2
    C,F,H--90744146(+) ATCGCC/AGCCGA 1 -- int114Minor allele frequency- A:0.05NA NS EA WA 1438
    rs454630971,2
    C,F--90744188(+) TGCAGG/ACCAGA 1 -- int17Minor allele frequency- A:0.18NA CSA WA EA 366
    rs791559821,2
    C,F--90744317(+) CACCAC/AGACAC 1 -- int12Minor allele frequency- A:0.13NA EA 240

    HapMap Linkage Disequilibrium report for NRDE2 (90742580 - 90798481 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NRDE2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRDE2
    DNA2.0 Custom Variant and Variant Library Synthesis for NRDE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRDE2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with NRDE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    3. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Joint influence of small-effect genetic variants on human longevity. (PubMed id 20834067)1 Yashin A.I....Ukraintseva S.V. (Aging (Albany NY) 2010)
    10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55051 HGNC: 20186 AceView: C14orf102 Ensembl:ENSG00000119720 euGenes: HUgn55051
    ECgene: NRDE2 H-InvDB: NRDE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRDE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRDE2 gene:
    Search GeneIP for patents involving NRDE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat NRDE2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NRDE2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRDE2 Predesigned siRNA for gene silencing in human, mouse, rat NRDE2
     QuantiFast Probe-based Assays in human, mouse, rat NRDE2 QuantiTect SYBR Green Assays in human, mouse, rat NRDE2
     Custom PCR Arrays for NRDE2 Search Chromatin IP Primers for NRDE2
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     GenScript Custom Purified and Recombinant Proteins Services for NRDE2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NRDE2
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     Browse ESI BIO Cell Lines and PureStem Progenitors for NRDE2
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     SwitchGear 3'UTR luciferase reporter plasmids for NRDE2
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      Search antibodies-online for peptides for NRDE2
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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