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Aliases for NRDC Gene

Aliases for NRDC Gene

  • Nardilysin Convertase 2 3 4 5
  • Nardilysin (N-Arginine Dibasic Convertase) 2 3
  • N-Arginine Dibasic Convertase 2 4
  • NRD Convertase 3 4
  • EC 4 61
  • NRD1 3 4
  • Nardilysin 3
  • EC 3.4.24 61
  • NRD-C 4
  • HNRD1 3
  • HNRD2 3

External Ids for NRDC Gene

Previous HGNC Symbols for NRDC Gene

  • NRD1

Summaries for NRDC Gene

Entrez Gene Summary for NRDC Gene

  • This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for NRDC Gene

NRDC (Nardilysin Convertase) is a Protein Coding gene. An important paralog of this gene is IDE.

UniProtKB/Swiss-Prot for NRDC Gene

  • Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Gene Wiki entry for NRDC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRDC Gene

Genomics for NRDC Gene

Regulatory Elements for NRDC Gene

Enhancers for NRDC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F051563 1.4 Ensembl ENCODE 10.2 +310.9 310920 9.3 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000266993 RNU6-1281P EPS15 ENSG00000227070 ZCCHC11 ENSG00000272100 MIR761 NRDC RNU6-877P CALR4P
GH01F051642 1.3 FANTOM5 Ensembl ENCODE 10.3 +235.1 235137 3.5 PKNOX1 JUN ZNF384 RAD21 CTBP1 ZNF366 PRDM10 FOS KLF8 ZNF362 OSBPL9 ENSG00000212624 MIR761 NRDC RNU6-877P LOC105378719 GAPDHP51
GH01F051733 1.1 Ensembl ENCODE 10.6 +144.6 144637 3.0 PKNOX1 WRNIP1 ZNF366 HMG20B REST ZFP69B GLIS1 THRAP3 IKZF1 CEBPA ZCCHC11 ENSG00000266993 NRDC MIR761 GC01P051733
GH01F051736 1.1 Ensembl ENCODE 10.6 +142.0 142019 0.6 HDGF TBL1XR1 JUN FEZF1 ZBTB40 CHAMP1 ZNF316 FOXK2 NFE2 MAFK NRDC MIR761 GC01P051733 ENSG00000266993
GH01F051728 1.1 ENCODE 10.4 +149.0 149031 3.4 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 FOS TXNDC12 NRDC MIR761 KTI12 RNU6-877P OSBPL9 GC01P051732 ENSG00000212624
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRDC on UCSC Golden Path with GeneCards custom track

Promoters for NRDC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001520167 937 4001 CREB3L1 MLX DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21

Genomic Location for NRDC Gene

51,789,191 bp from pter
51,878,937 bp from pter
89,747 bases
Minus strand

Genomic View for NRDC Gene

Genes around NRDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRDC Gene

Proteins for NRDC Gene

  • Protein details for NRDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NI41
    • O15241
    • O15242
    • Q5VUL0
    • Q96HB2
    • Q9NU57

    Protein attributes for NRDC Gene

    1150 amino acids
    Molecular mass:
    131572 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRDC Gene


neXtProt entry for NRDC Gene

Selected DME Specific Peptides for NRDC Gene


Post-translational modifications for NRDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NRDC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M16 family.
  • Belongs to the peptidase M16 family.
genes like me logo Genes that share domains with NRDC: view

No data available for Gene Families for NRDC Gene

Function for NRDC Gene

Molecular function for NRDC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of polypeptides, preferably at -Xaa- -Arg-Lys-, and less commonly at -Arg- -Arg-Xaa-, in which Xaa is not Arg or Lys.
UniProtKB/Swiss-Prot Function:
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Enzyme Numbers (IUBMB) for NRDC Gene

Gene Ontology (GO) - Molecular Function for NRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA,NAS 9581555
GO:0005515 protein binding IPI 18355445
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IBA --
genes like me logo Genes that share ontologies with NRDC: view
genes like me logo Genes that share phenotypes with NRDC: view

Animal Models for NRDC Gene

MGI Knock Outs for NRDC:

Animal Model Products

  • Taconic Biosciences Mouse Models for NRDC

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRDC Gene

Localization for NRDC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRDC gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3

Gene Ontology (GO) - Cellular Components for NRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS 12463163
GO:0009986 cell surface TAS 12463163
genes like me logo Genes that share ontologies with NRDC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NRDC Gene

Pathways & Interactions for NRDC Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,NAS 9581555
GO:0007528 neuromuscular junction development TAS 9479496
GO:0008283 cell proliferation TAS 12463163
GO:0016477 cell migration TAS 15544571
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with NRDC: view

No data available for Pathways by source and SIGNOR curated interactions for NRDC Gene

Drugs & Compounds for NRDC Gene

(2) Drugs for NRDC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NRDC: view

Transcripts for NRDC Gene

Unigene Clusters for NRDC Gene

Nardilysin (N-arginine dibasic convertase):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRDC Gene

No ASD Table

Relevant External Links for NRDC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRDC Gene

NURSA nuclear receptor signaling pathways regulating expression of NRDC Gene:


SOURCE GeneReport for Unigene cluster for NRDC Gene:


mRNA Expression by UniProt/SwissProt for NRDC Gene:

Tissue specificity: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NRDC Gene

Orthologs for NRDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NRDC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NRD1 34 35
  • 99.59 (n)
(Bos Taurus)
Mammalia NRD1 34 35
  • 93.96 (n)
(Canis familiaris)
Mammalia NRD1 34 35
  • 93.6 (n)
(Mus musculus)
Mammalia Nrd1 34 16 35
  • 90.59 (n)
(Rattus norvegicus)
Mammalia Nrd1 34
  • 89.24 (n)
(Monodelphis domestica)
Mammalia NRD1 35
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia NRD1 35
  • 75 (a)
(Gallus gallus)
Aves NRD1 34 35
  • 75.63 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 70 (a)
-- 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nrd1 34
  • 66.27 (n)
(Danio rerio)
Actinopterygii NRD1 (1 of 2) 35
  • 69 (a)
si:dkey-193b15.9 34
  • 68 (n)
nrd1 35
  • 64 (a)
wufk24c07 34
fruit fly
(Drosophila melanogaster)
Insecta CG10588 35
  • 31 (a)
CG2025 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE23 35
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06900 34
  • 47.34 (n)
(Oryza sativa)
Liliopsida Os03g0336300 34
  • 47.87 (n)
Species where no ortholog for NRDC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRDC Gene

Gene Tree for NRDC (if available)
Gene Tree for NRDC (if available)

Paralogs for NRDC Gene

Paralogs for NRDC Gene

genes like me logo Genes that share paralogs with NRDC: view

Variants for NRDC Gene

Sequence variations from dbSNP and Humsavar for NRDC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1004815 -- 51,793,053(+) CCCAC(C/G/T)CACCA intron-variant, upstream-variant-2KB
rs10158826 -- 51,801,838(+) gctgg(A/C)atgca intron-variant
rs10526165 -- 51,872,869(+) GTTAC(-/CTTTA)CTTTA intron-variant
rs1053031 -- 51,837,451(-) GGTTA(G/T)ATTGT intron-variant, upstream-variant-2KB
rs10551352 -- 51,870,936(+) AAAAA(-/CT)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRDC Gene

Variant ID Type Subtype PubMed ID
nsv956714 CNV insertion 24416366
nsv829837 CNV loss 17160897
nsv519495 CNV loss 19592680
nsv512738 CNV insertion 21212237
nsv1110660 CNV insertion 24896259
esv3586044 CNV gain 21293372
esv3349028 CNV insertion 20981092
esv2551965 CNV insertion 19546169
esv1684865 CNV insertion 17803354
esv1546529 CNV insertion 17803354
dgv82n106 CNV deletion 24896259

Variation tolerance for NRDC Gene

Residual Variation Intolerance Score: 3.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRDC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRDC Gene

Disorders for NRDC Gene

Relevant External Links for NRDC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NRDC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRDC Gene

Publications for NRDC Gene

  1. Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. (PMID: 9479496) Fumagalli P. … Taramelli R. (Genomics 1998) 2 3 4 22 64
  2. Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. (PMID: 9581555) Hospital V. … Cohen P. (Biochem. J. 1997) 2 3 4 22 64
  3. Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines. (PMID: 11042131) Winter A.G. … Pierotti A.R. (Biochem. J. 2000) 3 4 22 64
  4. Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. (PMID: 18355445) Hiraoka Y. … Nishi E. (Biochem. Biophys. Res. Commun. 2008) 3 22 64
  5. Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons. (PMID: 17442499) Bernstein H.G. … Reiser G. (Neuroscience 2007) 3 22 64

Products for NRDC Gene

Sources for NRDC Gene

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