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Aliases for NRDC Gene

Aliases for NRDC Gene

  • Nardilysin Convertase 2 3 4 5
  • Nardilysin (N-Arginine Dibasic Convertase) 2 3
  • N-Arginine Dibasic Convertase 2 4
  • NRD Convertase 3 4
  • EC 3.4.24.61 4 63
  • NRD1 3 4
  • EC 3.4.24 63
  • HNRD1 3
  • HNRD2 3
  • NRD-C 4

External Ids for NRDC Gene

Previous HGNC Symbols for NRDC Gene

  • NRD1

Summaries for NRDC Gene

Entrez Gene Summary for NRDC Gene

  • This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for NRDC Gene

NRDC (Nardilysin Convertase) is a Protein Coding gene. An important paralog of this gene is IDE.

UniProtKB/Swiss-Prot for NRDC Gene

  • Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Gene Wiki entry for NRDC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRDC Gene

Genomics for NRDC Gene

Regulatory Elements for NRDC Gene

Enhancers for NRDC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NRDC on UCSC Golden Path with GeneCards custom track

Promoters for NRDC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRDC on UCSC Golden Path with GeneCards custom track

Genomic Location for NRDC Gene

Chromosome:
1
Start:
51,789,191 bp from pter
End:
51,878,937 bp from pter
Size:
89,747 bases
Orientation:
Minus strand

Genomic View for NRDC Gene

Genes around NRDC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRDC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRDC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRDC Gene

Proteins for NRDC Gene

  • Protein details for NRDC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43847-NRDC_HUMAN
    Recommended name:
    Nardilysin
    Protein Accession:
    O43847
    Secondary Accessions:
    • A6NI41
    • O15241
    • O15242
    • Q5VUL0
    • Q96HB2
    • Q9NU57

    Protein attributes for NRDC Gene

    Size:
    1150 amino acids
    Molecular mass:
    131572 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRDC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRDC Gene

Proteomics data for NRDC Gene at MOPED

Selected DME Specific Peptides for NRDC Gene

Post-translational modifications for NRDC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NRDC Gene

Graphical View of Domain Structure for InterPro Entry

O43847

UniProtKB/Swiss-Prot:

NRDC_HUMAN :
  • Belongs to the peptidase M16 family.
Family:
  • Belongs to the peptidase M16 family.
genes like me logo Genes that share domains with NRDC: view

No data available for Gene Families for NRDC Gene

Function for NRDC Gene

Molecular function for NRDC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of polypeptides, preferably at -Xaa- -Arg-Lys-, and less commonly at -Arg- -Arg-Xaa-, in which Xaa is not Arg or Lys.
UniProtKB/Swiss-Prot Function:
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Enzyme Numbers (IUBMB) for NRDC Gene

Gene Ontology (GO) - Molecular Function for NRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IBA --
GO:0048408 epidermal growth factor binding TAS 12463163
genes like me logo Genes that share ontologies with NRDC: view
genes like me logo Genes that share phenotypes with NRDC: view

Animal Models for NRDC Gene

MGI Knock Outs for NRDC:

Animal Model Products

  • Taconic Biosciences Mouse Models for NRDC

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRDC Gene

Localization for NRDC Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NRDC Gene

Pathways & Interactions for NRDC Gene

SuperPathways for NRDC Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRDC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007528 neuromuscular junction development TAS 9479496
GO:0008152 metabolic process IEA --
GO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA 18355445
genes like me logo Genes that share ontologies with NRDC: view

No data available for Pathways by source and SIGNOR curated interactions for NRDC Gene

Drugs & Compounds for NRDC Gene

(2) Drugs for NRDC Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NRDC: view

Transcripts for NRDC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NRDC Gene

No ASD Table

Relevant External Links for NRDC Gene

GeneLoc Exon Structure for
NRDC
ECgene alternative splicing isoforms for
NRDC

Expression for NRDC Gene

mRNA Expression by UniProt/SwissProt for NRDC Gene

O43847-NRDC_HUMAN
Tissue specificity: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NRDC Gene

Orthologs for NRDC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NRDC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRD1 35
  • 93.96 (n)
  • 95.37 (a)
NRD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRD1 35
  • 93.6 (n)
  • 96.16 (a)
NRD1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrd1 35
  • 90.59 (n)
  • 93.38 (a)
Nrd1 16
Nrd1 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRD1 35
  • 99.59 (n)
  • 99.84 (a)
NRD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrd1 35
  • 89.24 (n)
  • 93.19 (a)
oppossum
(Monodelphis domestica)
Mammalia NRD1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRD1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRD1 35
  • 75.63 (n)
  • 79.51 (a)
NRD1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nrd1 35
  • 66.27 (n)
  • 66.54 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-193b15.9 35
  • 68 (n)
  • 74.17 (a)
wufk24c07 35
nrd1 36
  • 64 (a)
OneToMany
NRD1 (1 of 2) 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10588 36
  • 31 (a)
OneToMany
CG2025 36
  • 31 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE23 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06900 35
  • 47.34 (n)
  • 35.76 (a)
rice
(Oryza sativa)
Liliopsida Os03g0336300 35
  • 47.87 (n)
  • 36.56 (a)
Species with no ortholog for NRDC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRDC Gene

ENSEMBL:
Gene Tree for NRDC (if available)
TreeFam:
Gene Tree for NRDC (if available)

Paralogs for NRDC Gene

Paralogs for NRDC Gene

genes like me logo Genes that share paralogs with NRDC: view

Variants for NRDC Gene

Sequence variations from dbSNP and Humsavar for NRDC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_057058 -
rs8375 -- 51,800,570(-) AAGCC(C/G/T)GAGAC nc-transcript-variant, reference, synonymous-codon
rs706495 -- 51,827,966(+) ATTTA(A/G)TTCAC intron-variant
rs883058 -- 51,851,559(-) AAATC(A/T)TTTTT intron-variant
rs736756 -- 51,878,742(+) CCCCA(A/C)CCCAG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Variation tolerance for NRDC Gene

Residual Variation Intolerance Score: 3.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NRDC Gene

Disorders for NRDC Gene

Relevant External Links for NRDC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRDC

No disorders were found for NRDC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRDC Gene

Publications for NRDC Gene

  1. Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. (PMID: 9581555) Hospital V. … Cohen P. (Biochem. J. 1997) 2 3 4 23 67
  2. Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. (PMID: 9479496) Fumagalli P. … Taramelli R. (Genomics 1998) 2 3 23
  3. Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases. (PMID: 18355445) Hiraoka Y. … Nishi E. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons. (PMID: 17442499) Bernstein H.G. … Reiser G. (Neuroscience 2007) 3 23
  5. Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme. (PMID: 16923819) Nishi E. … Kita T. (J. Biol. Chem. 2006) 3 23

Products for NRDC Gene

Sources for NRDC Gene

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