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Aliases for NRD1 Gene

Aliases for NRD1 Gene

  • Nardilysin (N-Arginine Dibasic Convertase) 2 3
  • NRD Convertase 3 4
  • EC 3.4.24.61 4 63
  • NRD-C 3 4
  • N-Arginine Dibasic Convertase 4
  • Nardilysin 3
  • EC 3.4.24 63
  • HNRD1 3
  • HNRD2 3

External Ids for NRD1 Gene

Summaries for NRD1 Gene

Entrez Gene Summary for NRD1 Gene

  • This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for NRD1 Gene

NRD1 (Nardilysin (N-Arginine Dibasic Convertase)) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and epidermal growth factor binding. An important paralog of this gene is IDE.

UniProtKB/Swiss-Prot for NRD1 Gene

  • Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs

Gene Wiki entry for NRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRD1 Gene

Genomics for NRD1 Gene

Genomic Location for NRD1 Gene

Start:
51,789,191 bp from pter
End:
51,878,937 bp from pter
Size:
89,747 bases
Orientation:
Minus strand

Genomic View for NRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRD1 Gene

Regulatory Elements for NRD1 Gene

Proteins for NRD1 Gene

  • Protein details for NRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43847-NRDC_HUMAN
    Recommended name:
    Nardilysin
    Protein Accession:
    O43847
    Secondary Accessions:
    • A6NI41
    • O15241
    • O15242
    • Q5VUL0
    • Q96HB2
    • Q9NU57

    Protein attributes for NRD1 Gene

    Size:
    1150 amino acids
    Molecular mass:
    131572 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NRD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRD1 Gene

Proteomics data for NRD1 Gene at MOPED

Selected DME Specific Peptides for NRD1 Gene

Post-translational modifications for NRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys325, Lys341, Lys351, and Lys228

Domains for NRD1 Gene

Graphical View of Domain Structure for InterPro Entry

O43847

UniProtKB/Swiss-Prot:

NRDC_HUMAN
Family:
  • Belongs to the peptidase M16 family.:
    • O43847
genes like me logo Genes that share domains with NRD1: view

No data available for Gene Families for NRD1 Gene

Function for NRD1 Gene

Molecular function for NRD1 Gene

GENATLAS Biochemistry: nardilysin,N-arginine dibasic convertase,expressed in testis and in embryonic nervous system,involved in development
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of polypeptides, preferably at -Xaa- -Arg-Lys-, and less commonly at -Arg- -Arg-Xaa-, in which Xaa is not Arg or Lys
UniProtKB/Swiss-Prot Function: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs

Enzyme Numbers (IUBMB) for NRD1 Gene

Gene Ontology (GO) - Molecular Function for NRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004222 metalloendopeptidase activity NAS 9581555
GO:0005515 protein binding IPI 18355445
GO:0046872 metal ion binding IEA --
GO:0048408 epidermal growth factor binding TAS 12463163
genes like me logo Genes that share ontologies with NRD1: view
genes like me logo Genes that share phenotypes with NRD1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NRD1 Gene

Localization for NRD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRD1 Gene COMPARTMENTS Subcellular localization image for NRD1 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 1

Gene Ontology (GO) - Cellular Components for NRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005829 cytosol TAS 12463163
GO:0009986 cell surface TAS 12463163
genes like me logo Genes that share ontologies with NRD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NRD1 Gene

Pathways for NRD1 Gene

SuperPathways for NRD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 9581555
GO:0007528 neuromuscular junction development TAS 9479496
GO:0008283 cell proliferation TAS 12463163
GO:0016477 cell migration TAS 15544571
GO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA 18355445
genes like me logo Genes that share ontologies with NRD1: view

No data available for Pathways by source for NRD1 Gene

Compounds for NRD1 Gene

(2) Novoseek inferred chemical compound relationships for NRD1 Gene

Compound -log(P) Hits PubMed IDs
spermine 51.3 3
arginine 42.1 5
genes like me logo Genes that share compounds with NRD1: view

Transcripts for NRD1 Gene

Unigene Clusters for NRD1 Gene

Nardilysin (N-arginine dibasic convertase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - - - -
SP9: -
SP10: - -
SP11: - - - - -
SP12:
SP13: - - -
SP14:
SP15:
SP16:

ExUns: 19b · 19c ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:

ExUns: 37 ^ 38 ^ 39
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NRD1 Gene

GeneLoc Exon Structure for
NRD1
ECgene alternative splicing isoforms for
NRD1

Expression for NRD1 Gene

mRNA expression in normal human tissues for NRD1 Gene

mRNA differential expression in normal tissues according to GTEx for NRD1 Gene

This gene is overexpressed in Muscle - Skeletal (5.3) and Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRD1 Gene

SOURCE GeneReport for Unigene cluster for NRD1 Gene Hs.584782

mRNA Expression by UniProt/SwissProt for NRD1 Gene

O43847-NRDC_HUMAN
Tissue specificity: Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues
genes like me logo Genes that share expressions with NRD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NRD1 Gene

Orthologs for NRD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRD1 35
  • 99.59 (n)
  • 99.84 (a)
NRD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRD1 35
  • 93.96 (n)
  • 95.37 (a)
NRD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRD1 35
  • 93.6 (n)
  • 96.16 (a)
NRD1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrd1 35
  • 90.59 (n)
  • 93.38 (a)
Nrd1 16
Nrd1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRD1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRD1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrd1 35
  • 89.24 (n)
  • 93.19 (a)
chicken
(Gallus gallus)
Aves NRD1 35
  • 75.63 (n)
  • 79.51 (a)
NRD1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nrd1 35
  • 66.27 (n)
  • 66.54 (a)
zebrafish
(Danio rerio)
Actinopterygii nrd1 36
  • 64 (a)
OneToMany
NRD1 (1 of 2) 36
  • 69 (a)
OneToMany
si:dkey-193b15.9 35
  • 68 (n)
  • 74.17 (a)
wufk24c07 35
fruit fly
(Drosophila melanogaster)
Insecta CG10588 36
  • 31 (a)
OneToMany
CG2025 36
  • 31 (a)
OneToMany
CG2025 37
  • 36 (a)
CG10588 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE23 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06900 35
  • 47.34 (n)
  • 35.76 (a)
rice
(Oryza sativa)
Liliopsida Os03g0336300 35
  • 47.87 (n)
  • 36.56 (a)
Species with no ortholog for NRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRD1 Gene

ENSEMBL:
Gene Tree for NRD1 (if available)
TreeFam:
Gene Tree for NRD1 (if available)

Paralogs for NRD1 Gene

Paralogs for NRD1 Gene

Selected SIMAP similar genes for NRD1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NRD1: view

Variants for NRD1 Gene

Sequence variations from dbSNP and Humsavar for NRD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8375 -- 51,800,570(-) AAGCC(C/G/T)GAGAC reference, synonymous-codon
rs706495 -- 51,827,966(+) ATTTA(A/G)TTCAC intron-variant
rs736756 -- 51,878,742(+) CCCCA(A/C)CCCAG utr-variant-5-prime, upstream-variant-2KB
rs856605 -- 51,831,886(-) cagtg(A/G)tgtga intron-variant
rs856606 -- 51,830,784(-) GAAGC(C/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRD1 Gene

Variant ID Type Subtype PubMed ID
esv1546529 CNV Insertion 17803354
nsv519495 CNV Loss 19592680
nsv829837 CNV Loss 17160897
esv2551965 CNV Insertion 19546169
nsv512738 CNV Insertion 21212237
esv1684865 CNV Insertion 17803354

Relevant External Links for NRD1 Gene

HapMap Linkage Disequilibrium report
NRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRD1 Gene

Disorders for NRD1 Gene

(1) Novoseek inferred disease relationships for NRD1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for NRD1

Genetic Association Database (GAD)
NRD1
Human Genome Epidemiology (HuGE) Navigator
NRD1
genes like me logo Genes that share disorders with NRD1: view

No data available for UniProtKB/Swiss-Prot for NRD1 Gene

Publications for NRD1 Gene

  1. Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. (PMID: 9479496) Fumagalli P. … Taramelli R. (Genomics 1998) 2 3 4 23
  2. Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. (PMID: 9581555) Hospital V. … Cohen P. (Biochem. J. 1997) 2 3 4 23
  3. Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines. (PMID: 11042131) Winter A.G. … Pierotti A.R. (Biochem. J. 2000) 3 4 23
  4. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. (PMID: 11432822) Nishi E. … Klagsbrun M. (EMBO J. 2001) 3 23
  5. Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation. (PMID: 15544571) Hospital V. … Prat A. (Protein Pept. Lett. 2004) 3 23

Products for NRD1 Gene

Sources for NRD1 Gene

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