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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NRCAM Gene

protein-coding   GIFtS: 62
GCID: GC07M107788

neuronal cell adhesion molecule
 Explore 24 diseases affiliated with
NRCAM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NRCAM    

Aliases
for NRCAM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neuronal Cell Adhesion Molecule1 2     Bravo1
KIAA03431 3     Ng-CAM-Related1
Neuronal Surface Protein Bravo2 3     Nr-CAM3
NgCAM-Related Cell Adhesion Molecule2 3     HBravo1

External Ids:    HGNC: 79941   Entrez Gene: 48972   Ensembl: ENSG000000911297   OMIM: 6015815   UniProtKB: Q928233   

Export aliases for NRCAM gene to outside databases

Previous GC identifers: GC07M106271 GC07M107334 GC07M107348 GC07M107382 GC07M107575 GC07M102150


Summaries
for NRCAM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NRCAM:
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell
adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This
ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone
growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via
signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants
of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple
transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NRCAM_HUMAN, Q92823
Function: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular
assembly of the nodes of Ranvier (By similarity)

Gene Wiki entry for NRCAM


Genomic Views
for NRCAM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NRCAM gene promoter:
         Nkx3-1   AP-2alpha isoform 3   FOXD3   Nkx3-1 v1   AP-2alpha isoform 2   Nkx2-5   Roaz   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): NRCAM promoter sequence
   Search SABiosciences Chromatin IP Primers for NRCAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NRCAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31

NRCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRCAM gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M107788:  view genomic region     (about GC identifiers)

Start:
 107,788,071 bp from pter      End:
 108,097,161 bp from pter
Size:
 309,091 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 107,149,256-107,464,062     

Proteins
for NRCAM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NRCAM_HUMAN, Q92823 (See protein sequence)
Recommended Name: Neuronal cell adhesion molecule precursor  
Size: 1304 amino acids; 143890 Da
Subunit: Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Interacts with GLDN/gliomedin (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAC50765.1; Type=Erroneous initiation; Sequence=BAA20801.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for NRCAM:
1UEN (3D)        1UEY (3D)    
Secondary accessions: A4D0S3 E9PDA4 O15051 O15179 Q14BM2 Q9UHI3 Q9UHI4
Alternative splicing: 6 isoforms:  Q92823-1   Q92823-2   Q92823-3   Q92823-4   Q92823-5   Q92823-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NRCAM: NX_Q92823

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92823

    • NRCAM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001032209.1  NP_001180511.1  NP_001180512.1  NP_001180513.1  NP_005001.3  

    ENSEMBL proteins: 
     ENSP00000325269   ENSP00000368310   ENSP00000401244   ENSP00000398174   ENSP00000390421  
     ENSP00000390868   ENSP00000397544   ENSP00000408203   ENSP00000393663   ENSP00000368314  
     ENSP00000407858   ENSP00000368308  
    Reactome Protein details: Q92823
    Human Recombinant Protein Products: 
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    Novus Biologicals NRCAM Protein
    Novus Biologicals NRCAM Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NRCAM

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS8812479
    GO:0009897external side of plasma membrane NAS8812479
    GO:0030424axon ----
    GO:0043005neuron projection NAS8812479


    NRCAM for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NRCAM

    Protein Domains /
    Families
    for NRCAM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NRCAM for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS
     IPR003599 Ig_sub
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry Q92823

    ProtoNet protein and cluster: Q92823

    3 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB003962 Fibronectin type III repeat signature
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: NRCAM_HUMAN, Q92823
    Similarity: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family
    Similarity: Contains 5 fibronectin type-III domains
    Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for NRCAM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NRCAM_HUMAN, Q92823
    Function: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular
    assembly of the nodes of Ranvier (By similarity)

         Genatlas biochemistry entry for NRCAM:
    neuron-glia-CAM-related cell-adhesion molecule,murine Nrcam homolog

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NRCAM
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate NRCAM (see all 31):
    hsa-miR-3673 hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-4272 hsa-miR-200a hsa-miR-132 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: NRCAM 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030506ankyrin binding IDA14602817


    NRCAM for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NRCAM: Nrcamtm1Fgr Nrcamtm1Gmt
         7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Nrcam):
     behavior/neurological  growth/size  mortality/aging  muscle  nervous system 
     skeleton  vision/eye 

    NRCAM for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NRCAM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    2NrCAM interactions
    		NrCAM interactions1.00
    3Neurofascin interactions
    		Neurofascin interactions1.00
    4Interaction between L1 and Ankyrins
    		Interaction between L1 and Ankyrins1.00
    5WNT Signaling
    		WNT Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NRCAM
        WNT Signaling

    5/6        Reactome Pathways for NRCAM (see all 6)
        L1CAM interactions
    Developmental Biology
    Interaction between L1 and Ankyrins
    NrCAM interactions
    Axon guidance


    1         Kegg Pathway  (Kegg details for NRCAM):
        Cell adhesion molecules (CAMs)


    NRCAM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NRCAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/22 Interacting proteins for NRCAM (Q928233 ENSP000003683144) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNTN2Q022463, ENSP000003306334I2D: score=2 STRING: ENSP00000330633
    HSPA12AO433013, ENSP000003582114I2D: score=2 STRING: ENSP00000358211
    PTPRBP234673, ENSP000003349284I2D: score=2 STRING: ENSP00000334928
    ANK2Q014843, ENSP000003495884I2D: score=1 STRING: ENSP00000349588
    NFASCO948563, ENSP000003531544I2D: score=1 STRING: ENSP00000353154
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEP11866539
    GO:0001764neuron migration NAS11483367
    GO:0007409axonogenesis NAS8812479
    GO:0007411axon guidance TAS--
    GO:0007413axonal fasciculation NAS8812479


    NRCAM for ontologies           About GeneDecksing



    Drugs & Compounds
    for NRCAM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NRCAM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NRCAM
    3 Novoseek chemical compound relationships for NRCAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 26.5 5 15466474 (2), 10586239 (1), 17548513 (1)
    tyrosine 0 1 9049255 (1)
    potassium 0 1 12687693 (1)

    Search CenterWatch for drugs/clinical trials and news about NRCAM 

    Transcripts
    for NRCAM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NRCAM gene (6 alternative transcripts): 
    NM_001037132.2  NM_001193582.1  NM_001193583.1  NM_001193584.1  NM_005010.4  NM_001037133.1  

    Unigene Cluster for NRCAM:

    Neuronal cell adhesion molecule
    Hs.21422  [show with all ESTs]
    Unigene Representative Sequence: NM_001193582
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522550(uc003vez.3) ENST00000351718 ENST00000379024 ENST00000425651
    ENST00000445634 ENST00000415105 ENST00000465585 ENST00000417701 ENST00000489800
    ENST00000442580 ENST00000419936 ENST00000456431 ENST00000418239 ENST00000379028(uc022aka.1 uc011kmk.2 uc003vfd.3 uc003vfe.3 uc003vfc.3)
    ENST00000413765(uc003vfa.3 uc011kmj.2) ENST00000379022

    miRNA
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    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate NRCAM (see all 31):
    hsa-miR-3673 hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-4272 hsa-miR-200a hsa-miR-132 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: NRCAM 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NRCAM (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB002341.1 AB075506.1 AJ001054.1 AJ001057.1 AK092330.1 AK294195.1 AK299870.1 AY528240.1 
    BC098401.1 BC114570.1 BC115736.1 BX538010.1 

    18 DOTS entries:

    DT.97821201  DT.100737120  DT.97869753  DT.86771759  DT.100737142  DT.86859587  DT.100735884  DT.101970549 
    DT.121068564  DT.422568  DT.101967885  DT.121068581  DT.121068627  DT.121068636  DT.70102170  DT.91782811 
    DT.121068585  DT.40282744 

    24/152 AceView cDNA sequences (see all 152):

    BF939818 AI422418 BI793309 BM664768 BQ720297 AI191660 AA805238 CK300166 
    AK127035 BM675169 CB155841 AI031622 F11538 AA186616 BM966836 BF940053 
    BF511567 AA405668 Z38393 AJ001054 AA885787 AI056167 AI273785 F09200 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NRCAM    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^
    SP1:                                                                                                                                                  -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:        -     -               
    SP2:        -     -               
    SP3:                              


    ECgene alternative splicing isoforms for NRCAM

    Expression
    for NRCAM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NRCAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGGGTCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NRCAM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeForegutForegut Endoderm CellsEndoderm
    LungTracheaBasal CellsLung
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    White adipocyte-like cells (Differentiation of ...)Adipose
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage

    See NRCAM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NRCAM

    SOURCE GeneReport for Unigene cluster: Hs.21422

    UniProtKB/Swiss-Prot: NRCAM_HUMAN, Q92823
    Tissue specificity: Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate
    nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus

        SABiosciences Expression via Pathway-Focused PCR Arrays including NRCAM: 
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              WNT Signaling Targets in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRCAM

    Orthologs
    for NRCAM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NRCAM gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NRCAM1 neuronal cell adhesion molecule 77.42(n)
    81.15(a)    		   396202  NM_205266.1  NP_990597.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NRCAM6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 5(56211530-56289083)
    zebrafish
    (Danio rerio)    		 Actinopterygii BC055495.12   -- 71.62(n)   393466  BC055495.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Nrg1 , 3 neuronal cell adhesion cell adhesion
    molecule3
    Neuroglian1    		 32(a)3
    44.36(n)1
    35.19(a)1    		   317921  NM_167160.21  NP_727274.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea lad-13
    lad-21    		 neural adhesion protein3
    Protein LAD-21    		 28(a)
    (best of 2)3
    43.6(n)1
    30.26(a)1    		   IV(8062655-8082948)3
    1770781  NM_001028325.11  NP_001023496.11 


    ENSEMBL Gene Tree for NRCAM (if available)
    TreeFam Gene Tree for NRCAM (if available) 

    Paralogs
    for NRCAM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NRCAM gene
    CHL12  CNTN22  DSCAM2  CNTN62  CNTN52  CNTN42  NFASC2  CNTN32  
    SDK22  SDK12  DSCAML12  L1CAM2  CNTN12  
    11 SIMAP similar genes for NRCAM using alignment to 12 protein entries:     NRCAM_HUMAN (see all proteins):
    NFASC    PXDN    L1CAM    CHL1    MUSK    ROBO3
    FGFR1    ROBO1    ROBO2    CNTN5    CNTN2

    NRCAM for paralogs           About GeneDecksing



    Genomic Variants
    for NRCAM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5558 NCBI SNPs in NRCAM are shown (see all 5558)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs102403371,2
    		C,--102166639(+) ATACCA/Gggtgg 5 -- int10--------
    rs102404671,2
    		C,--102166699(+) ataccA/Gggtgg 5 -- int10--------
    rs113980291,2
    		C--102181893(+) TAAGGG/-ACTAC 5 -- int11Minor allele frequency- -:0.00NA 2
    rs2015696691,2
    		C--102203813(+) TAGAAA/CCCCCC 1 -- int10--------
    rs796977781,2
    		F,--102209928(+) AAAAAA/GAAAAA 5 -- int11Minor allele frequency- G:0.02EA 120
    rs1135922701,2
    		C--102229626(+) TTGCAA/TGGCAA 5 -- int11Minor allele frequency- T:0.00NA 2
    rs351746171,2
    		C--102239523(+) TCTGCT/-TTTTT 5 -- int11Minor allele frequency- -:0.50NA 2
    rs2010089581,2
    		C--102251078(-) ACATTC/TTTTTT 4 -- int10--------
    rs777958871,2
    		C,--102261452(+) AGATAA/GATCTC 1 -- int10--------
    rs717723161,2
    		C--102291903(+) TAATCAAAGTT/-
                AAAAC     		4 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for NRCAM (107788071 - 108038071 bp, first 250kb of NRCAM)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NRCAM
         2 CNVs: 4554 23822
         1 Indel: 64915

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    Disorders / Diseases
    for NRCAM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NRCAM for disorders           About GeneDecksing

    OMIM gene information: 601581    OMIM disorders: --

    20/24 diseases for NRCAM (see all 24):    About MalaCards
    st. louis encephalitis    neuronitis    autism spectrum disorder    corpus callosum
    masa syndrome    crash syndrome    intellectual disability    papillary thyroid carcinoma
    encephalitis    thyroid carcinoma    hydrocephalus    paraplegia
    hepatic adenoma    cataract    thyroiditis    adenoma
    melanoma    colon cancer    colorectal cancer    hepatitis

    1 disease from the University of Copenhagen DISEASES database for NRCAM:
    Hydrocephalus

    3 Novoseek disease relationships for NRCAM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma b16 44.8 6 16357171 (2), 12183361 (1)
    tumors 0 3 16357171 (1), 12183361 (1)
    melanoma 0 2 16357171 (1), 12183361 (1)

    Human Genome Epidemiology (HuGE) Navigator: NRCAM (11 documents)

    Export disorders for NRCAM gene to outside databases

    Publications
    for NRCAM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NRCAM gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with NRCAM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31. (PubMed id 8812479)1, 2, 3 Lane R.P....Dreyer W.J. (1996)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily. (PubMed id 11483367)1, 2 Dry K.... Platzer M. (2001)
    5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    6. Association analysis of the NrCAM gene in autism and in subsets of families with severe obsessive-compulsive or self-stimulatory behaviors. (PubMed id 17106428)1, 9 Sakurai T....Buxbaum J.D. (2006)
    7. Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites. (PubMed id 8922386)1, 9 Volkmer H....Rathjen F.G. (1996)
    8. Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. (PubMed id 12183361)1, 9 Conacci-Sorrell M.E....Ben-Ze'ev A. (2002)
    9. Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. (PubMed id 11866539)1, 9 Aitkenhead M....Hughes C.C. (2002)
    10. Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. (PubMed id 9049255)1, 9 Sakurai T....Grumet M. (1997)

    External Searches for NRCAM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing NRCAM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4897 HGNC: 7994 AceView: NRCAM Ensembl:ENSG00000091129 euGenes: HUgn4897
    ECgene: NRCAM Kegg: 4897 H-InvDB: NRCAM

    Other Databases showing NRCAM gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0343

    Specialized Databases showing NRCAM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NRCAM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NRCAM Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NRCAM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NRCAM gene:
    Search GeneIP for patents involving NRCAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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