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Aliases for NRCAM Gene

Aliases for NRCAM Gene

  • Neuronal Cell Adhesion Molecule 2 3
  • NgCAM-Related Cell Adhesion Molecule 2 4
  • Neuronal Surface Protein Bravo 4
  • Ng-CAM-Related 4
  • KIAA0343 4
  • Nr-CAM 4
  • HBravo 4

External Ids for NRCAM Gene

Previous GeneCards Identifiers for NRCAM Gene

  • GC07M106271
  • GC07M107334
  • GC07M107348
  • GC07M107382
  • GC07M107575
  • GC07M107788
  • GC07M102150

Summaries for NRCAM Gene

Entrez Gene Summary for NRCAM Gene

  • Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for NRCAM Gene

NRCAM (Neuronal Cell Adhesion Molecule) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include ankyrin binding and protein binding involved in heterotypic cell-cell adhesion. An important paralog of this gene is PRTG.

UniProtKB/Swiss-Prot for NRCAM Gene

  • Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity).

Gene Wiki entry for NRCAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRCAM Gene

Genomics for NRCAM Gene

Genomic Location for NRCAM Gene

Start:
108,147,623 bp from pter
End:
108,456,717 bp from pter
Size:
309,095 bases
Orientation:
Minus strand

Genomic View for NRCAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRCAM Gene

Proteins for NRCAM Gene

  • Protein details for NRCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92823-NRCAM_HUMAN
    Recommended name:
    Neuronal cell adhesion molecule
    Protein Accession:
    Q92823
    Secondary Accessions:
    • A4D0S3
    • E9PDA4
    • O15051
    • O15179
    • Q14BM2
    • Q9UHI3
    • Q9UHI4

    Protein attributes for NRCAM Gene

    Size:
    1304 amino acids
    Molecular mass:
    143890 Da
    Quaternary structure:
    • Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC.
    SequenceCaution:
    • Sequence=AAC50765.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA20801.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NRCAM Gene

    Alternative splice isoforms for NRCAM Gene

neXtProt entry for NRCAM Gene

Proteomics data for NRCAM Gene at MOPED

Post-translational modifications for NRCAM Gene

  • Glycosylation at Asn83, Asn223, Asn245, Asn251, Asn276, Asn314, Asn433, Asn507, Asn619, Asn716, Asn802, Asn858, Asn993, Asn1009, Asn1019, Asn1072, Asn1083, and Asn1115
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRCAM Gene

Domains for NRCAM Gene

Gene Families for NRCAM Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Graphical View of Domain Structure for InterPro Entry

Q92823

UniProtKB/Swiss-Prot:

NRCAM_HUMAN :
  • Q92823
Domain:
  • Contains 5 fibronectin type-III domains.
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
genes like me logo Genes that share domains with NRCAM: view

Function for NRCAM Gene

Molecular function for NRCAM Gene

GENATLAS Biochemistry: neuron-glia-CAM-related cell-adhesion molecule,murine Nrcam homolog
UniProtKB/Swiss-Prot Function: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity).

Gene Ontology (GO) - Molecular Function for NRCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23897819
GO:0030506 ankyrin binding IDA 14602817
GO:0086080 protein binding involved in heterotypic cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with NRCAM: view
genes like me logo Genes that share phenotypes with NRCAM: view

Animal Models for NRCAM Gene

MGI Knock Outs for NRCAM:

miRNA for NRCAM Gene

miRTarBase miRNAs that target NRCAM

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NRCAM Gene

Localization for NRCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRCAM Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRCAM Gene COMPARTMENTS Subcellular localization image for NRCAM gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NRCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8812479
GO:0009897 external side of plasma membrane NAS 8812479
GO:0030424 axon --
GO:0043005 neuron projection NAS 8812479
genes like me logo Genes that share ontologies with NRCAM: view

Pathways for NRCAM Gene

genes like me logo Genes that share pathways with NRCAM: view

Pathways by source for NRCAM Gene

1 KEGG pathway for NRCAM Gene

Gene Ontology (GO) - Biological Process for NRCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0001764 neuron migration NAS 11483367
GO:0007409 axonogenesis NAS 8812479
GO:0007411 axon guidance TAS --
GO:0007413 axonal fasciculation NAS 8812479
genes like me logo Genes that share ontologies with NRCAM: view

Compounds for NRCAM Gene

(3) Novoseek inferred chemical compound relationships for NRCAM Gene

Compound -log(P) Hits PubMed IDs
sodium 26.5 4
tyrosine 0 1
potassium 0 1
genes like me logo Genes that share compounds with NRCAM: view

Transcripts for NRCAM Gene

Unigene Clusters for NRCAM Gene

Neuronal cell adhesion molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRCAM Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^
SP1: -
SP2:
SP3:

ExUns: 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - -
SP2: - -
SP3:

Relevant External Links for NRCAM Gene

GeneLoc Exon Structure for
NRCAM
ECgene alternative splicing isoforms for
NRCAM

Expression for NRCAM Gene

mRNA expression in normal human tissues for NRCAM Gene

mRNA differential expression in normal tissues according to GTEx for NRCAM Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.7), Brain - Anterior cingulate cortex (BA24) (6.1), Brain - Cortex (4.6), and Brain - Amygdala (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRCAM Gene

SOURCE GeneReport for Unigene cluster for NRCAM Gene Hs.21422

mRNA Expression by UniProt/SwissProt for NRCAM Gene

Q92823-NRCAM_HUMAN
Tissue specificity: Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus
genes like me logo Genes that share expressions with NRCAM: view

Orthologs for NRCAM Gene

This gene was present in the common ancestor of animals.

Orthologs for NRCAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRCAM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRCAM 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRCAM 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrcam 35
  • 88.38 (n)
  • 93.39 (a)
Nrcam 16
Nrcam 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRCAM 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRCAM 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrcam 35
  • 88.17 (n)
  • 93.23 (a)
chicken
(Gallus gallus)
Aves NRCAM 35
  • 77.44 (n)
  • 81.15 (a)
NRCAM 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRCAM 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrcam 35
  • 70.59 (n)
  • 71.84 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
NRCAM (3 of 3) 36
  • 53 (a)
OneToMany
nrcama 35
  • 63.11 (n)
  • 63.29 (a)
nrcama 36
  • 61 (a)
OneToMany
nrcamb 36
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000720 35
  • 43.06 (n)
  • 35.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nrg 35
  • 44.15 (n)
  • 35.36 (a)
Nrg 36
  • 31 (a)
OneToOne
Nrg 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea lad-2 35
  • 44.04 (n)
  • 30.69 (a)
lad-2 36
  • 29 (a)
OneToMany
sax-7 36
  • 26 (a)
OneToMany
lad-1 37
  • 28 (a)
Y54G2A.25 37
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for NRCAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRCAM Gene

ENSEMBL:
Gene Tree for NRCAM (if available)
TreeFam:
Gene Tree for NRCAM (if available)

Paralogs for NRCAM Gene

genes like me logo Genes that share paralogs with NRCAM: view

Variants for NRCAM Gene

Sequence variations from dbSNP and Humsavar for NRCAM Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1155 -- 108,267,583(+) ATTTC(A/T)CACAT intron-variant
rs97904 -- 108,183,622(-) GAGGC(A/G)GAGGT intron-variant
rs107588 -- 108,181,304(-) GATTT(C/T)ATATT intron-variant
rs107589 -- 108,181,276(-) CAAGC(A/G)TACAG intron-variant
rs125686 -- 108,182,966(-) TTGTG(C/T)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRCAM Gene

Variant ID Type Subtype PubMed ID
nsv831089 CNV Loss 17160897
nsv831090 CNV Loss 17160897
nsv888941 CNV Loss 21882294
esv2735001 CNV Deletion 23290073
nsv5894 CNV Insertion 18451855
nsv509220 CNV Insertion 20534489
nsv365475 CNV Loss 16902084
esv1688012 CNV Deletion 17803354
esv270868 CNV Insertion 20981092
esv274616 CNV Insertion 20981092
esv1781344 CNV Insertion 17803354
esv1008394 CNV Insertion 20482838
nsv5895 CNV Insertion 18451855
dgv7438n71 CNV Loss 21882294
esv22031 CNV Loss 19812545

Relevant External Links for NRCAM Gene

HapMap Linkage Disequilibrium report
NRCAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRCAM Gene

Disorders for NRCAM Gene

(1) University of Copenhagen DISEASES for NRCAM Gene

(3) Novoseek inferred disease relationships for NRCAM Gene

Disease -log(P) Hits PubMed IDs
melanoma b16 44.8 3
tumors 0 2
melanoma 0 2

Relevant External Links for NRCAM

Genetic Association Database (GAD)
NRCAM
Human Genome Epidemiology (HuGE) Navigator
NRCAM
genes like me logo Genes that share disorders with NRCAM: view

No data available for UniProtKB/Swiss-Prot for NRCAM Gene

Publications for NRCAM Gene

  1. Association analysis of the NrCAM gene in autism and in subsets of families with severe obsessive-compulsive or self-stimulatory behaviors. (PMID: 17106428) Sakurai T. … Buxbaum J.D. (Psychiatr. Genet. 2006) 3 23 48
  2. Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31. (PMID: 8812479) Lane R.P. … Dreyer W.J. (Genomics 1996) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  4. The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily. (PMID: 11483367) Dry K. … Platzer M. (Gene 2001) 3 4
  5. Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites. (PMID: 8922386) Volkmer H. … Rathjen F.G. (J. Cell Biol. 1996) 3 23

Products for NRCAM Gene

Sources for NRCAM Gene

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