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Aliases for NRBP2 Gene

Aliases for NRBP2 Gene

  • Nuclear Receptor Binding Protein 2 2 3 5
  • Transformation-Related Gene 16 Protein 4
  • Nuclear Receptor-Binding Protein 2 3
  • Transformation-Related Protein 16 3
  • TRG-16 4
  • Pp9320 3
  • TRG16 3

External Ids for NRBP2 Gene

Previous GeneCards Identifiers for NRBP2 Gene

  • GC08M144988
  • GC08M144917
  • GC08M140168
  • GC08M144919

Summaries for NRBP2 Gene

GeneCards Summary for NRBP2 Gene

NRBP2 (Nuclear Receptor Binding Protein 2) is a Protein Coding gene. Diseases associated with NRBP2 include Mental Retardation-Hypotonic Facies Syndrome, X-Linked. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NRBP1.

UniProtKB/Swiss-Prot for NRBP2 Gene

  • May regulate apoptosis of neural progenitor cells during their differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP2 Gene

Genomics for NRBP2 Gene

Regulatory Elements for NRBP2 Gene

Enhancers for NRBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F144002 1.1 Ensembl ENCODE 10.8 -163.5 -163530 3.5 HDAC1 PKNOX1 SAP130 MAX CEBPG THRB RAD21 YY1 GATA3 SCRT2 PLEC WDR97 EXOSC4 ENSG00000255224 MIR6847 MIR661 GPAA1 CYC1 MAF1 SHARPIN
GH08F143905 0.9 ENCODE 11.6 -65.3 -65285 1.5 HDAC1 ELF3 TBP ARID4B DMAP1 ZNF48 RAD21 RARA SLC30A9 CBX5 PLEC EPPK1 PUF60 MIR661 NRBP2 MIR6845 MIR937 SCRIB SPATC1 PARP10
GH08F143903 0.8 Ensembl ENCODE 11.6 -63.6 -63593 1.8 PKNOX1 RFX1 POLR2A KLF9 MNT RAD21 TRIM28 PLEC EPPK1 PUF60 MIR661 MIR6845 NRBP2 MIR937 SCRIB PARP10 SPATC1
GH08F143841 0.9 ENCODE 0.8 -0.5 -538 2.6 CBX3 CREB3L1 SIN3A ZBTB40 KAT2B GLIS2 SCRT2 ZNF143 EGR2 ZNF280D NAPRT NRBP2 MIR6845 GC08M143801
GH08F143840 0.5 ENCODE 0.8 +0.9 891 0.2 FOXP2 ZBTB40 PRDM2 GC08P143837 NRBP2 MIR6845
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRBP2 on UCSC Golden Path with GeneCards custom track

Promoters for NRBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404267 -126 1401 CREB3L1 SIN3A ZBTB40 KAT2B GLIS2 EGR2 SP3 REST SP1 GLIS1

Genomic Location for NRBP2 Gene

Chromosome:
8
Start:
143,830,016 bp from pter
End:
143,840,974 bp from pter
Size:
10,959 bases
Orientation:
Minus strand

Genomic View for NRBP2 Gene

Genes around NRBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP2 Gene

Proteins for NRBP2 Gene

  • Protein details for NRBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSY0-NRBP2_HUMAN
    Recommended name:
    Nuclear receptor-binding protein 2
    Protein Accession:
    Q9NSY0
    Secondary Accessions:
    • B4DF59
    • Q2HIX8
    • Q597G7
    • Q8NCX8
    • Q8WYS5

    Protein attributes for NRBP2 Gene

    Size:
    501 amino acids
    Molecular mass:
    57803 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI13874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB70864.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NRBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRBP2 Gene

Post-translational modifications for NRBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NRBP2 Gene

Domains & Families for NRBP2 Gene

Gene Families for NRBP2 Gene

Protein Domains for NRBP2 Gene

Suggested Antigen Peptide Sequences for NRBP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSY0

UniProtKB/Swiss-Prot:

NRBP2_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP2: view

Function for NRBP2 Gene

Molecular function for NRBP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate apoptosis of neural progenitor cells during their differentiation.

Gene Ontology (GO) - Molecular Function for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NRBP2: view
genes like me logo Genes that share phenotypes with NRBP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NRBP2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NRBP2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRBP2 Gene

Localization for NRBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRBP2 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with NRBP2: view

Pathways & Interactions for NRBP2 Gene

SuperPathways for NRBP2 Gene

No Data Available

Interacting Proteins for NRBP2 Gene

Selected Interacting proteins: Q9NSY0-NRBP2_HUMAN for NRBP2 Gene via IID

Gene Ontology (GO) - Biological Process for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IBA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0007399 nervous system development IEA --
GO:0016242 negative regulation of macroautophagy IMP 22354037
GO:0030182 neuron differentiation ISS --
genes like me logo Genes that share ontologies with NRBP2: view

No data available for Pathways by source and SIGNOR curated interactions for NRBP2 Gene

Transcripts for NRBP2 Gene

Unigene Clusters for NRBP2 Gene

Nuclear receptor binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NRBP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for NRBP2 Gene

GeneLoc Exon Structure for
NRBP2
ECgene alternative splicing isoforms for
NRBP2

Expression for NRBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRBP2 Gene

Protein differential expression in normal tissues from HIPED for NRBP2 Gene

This gene is overexpressed in Spinal cord (22.1) and Frontal cortex (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NRBP2 Gene



Protein tissue co-expression partners for NRBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRBP2 Gene:

NRBP2

SOURCE GeneReport for Unigene cluster for NRBP2 Gene:

Hs.521926
genes like me logo Genes that share expression patterns with NRBP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NRBP2 Gene

Orthologs for NRBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRBP2 34 35
  • 99.2 (n)
mouse
(Mus musculus)
Mammalia Nrbp2 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRBP2 34 35
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia Nrbp2 34
  • 88.34 (n)
dog
(Canis familiaris)
Mammalia NRBP2 34 35
  • 88.15 (n)
oppossum
(Monodelphis domestica)
Mammalia NRBP2 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRBP2 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRBP2 34 35
  • 70.11 (n)
lizard
(Anolis carolinensis)
Reptilia NRBP2 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nrbp2 34 35
  • 66.74 (n)
NRBP2 (1 of 2) 35
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Madm 35
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-11 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 35
  • 38 (a)
OneToMany
Species where no ortholog for NRBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NRBP2 Gene

ENSEMBL:
Gene Tree for NRBP2 (if available)
TreeFam:
Gene Tree for NRBP2 (if available)

Paralogs for NRBP2 Gene

Paralogs for NRBP2 Gene

(2) SIMAP similar genes for NRBP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRBP2: view

Variants for NRBP2 Gene

Sequence variations from dbSNP and Humsavar for NRBP2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10091644 -- 143,831,703(+) CAGAG(A/G)TAAAT intron-variant, downstream-variant-500B
rs111235139 -- 143,836,048(+) CGGGG(C/T)GTGGT intron-variant, reference, missense
rs111489996 -- 143,838,606(+) CCAGG(C/T)CTGCC intron-variant, upstream-variant-2KB
rs111595359 -- 143,836,277(+) AAAGG(G/T)GGGAA intron-variant
rs111660102 -- 143,840,351(+) ACTCT(A/G)CGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRBP2 Gene

Variant ID Type Subtype PubMed ID
nsv950014 CNV deletion 24416366
nsv824782 CNV gain+loss 20364138
nsv612897 CNV loss 21841781
nsv612896 CNV loss 21841781
nsv466009 CNV loss 19166990
nsv1161815 CNV deletion 26073780
nsv1077075 CNV deletion 25765185
dgv3931n106 CNV deletion 24896259

Variation tolerance for NRBP2 Gene

Gene Damage Index Score: 3.71; 57.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP2 Gene

Disorders for NRBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mental retardation-hypotonic facies syndrome, x-linked
  • mental retardation-hypotonic facies syndrome, x-linked, 1
- elite association - COSMIC cancer census association via MalaCards
Search NRBP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRBP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRBP2
genes like me logo Genes that share disorders with NRBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRBP2 Gene

Publications for NRBP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for NRBP2 Gene

Sources for NRBP2 Gene

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