Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NRBP2 Gene

Aliases for NRBP2 Gene

  • Nuclear Receptor Binding Protein 2 2 3
  • Transformation-Related Gene 16 Protein 4
  • Nuclear Receptor-Binding Protein 2 3
  • Transformation-Related Protein 16 3
  • Pp9320 3
  • TRG-16 4
  • TRG16 3

External Ids for NRBP2 Gene

Previous GeneCards Identifiers for NRBP2 Gene

  • GC08M144988
  • GC08M144917
  • GC08M140168
  • GC08M144919

Summaries for NRBP2 Gene

GeneCards Summary for NRBP2 Gene

NRBP2 (Nuclear Receptor Binding Protein 2) is a Protein Coding gene. Diseases associated with NRBP2 include medulloblastoma. GO annotations related to this gene include nucleotide binding and protein kinase activity. An important paralog of this gene is NRBP1.

UniProtKB/Swiss-Prot for NRBP2 Gene

  • May regulate apoptosis of neural progenitor cells during their differentiation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP2 Gene

Genomics for NRBP2 Gene

Regulatory Elements for NRBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NRBP2 Gene

143,830,717 bp from pter
143,842,028 bp from pter
11,312 bases
Minus strand

Genomic View for NRBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP2 Gene

Proteins for NRBP2 Gene

  • Protein details for NRBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear receptor-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DF59
    • Q2HIX8
    • Q597G7
    • Q8NCX8
    • Q8WYS5

    Protein attributes for NRBP2 Gene

    501 amino acids
    Molecular mass:
    57803 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI13874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB70864.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NRBP2 Gene


neXtProt entry for NRBP2 Gene

Proteomics data for NRBP2 Gene at MOPED

Post-translational modifications for NRBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NRBP2 Gene

Domains for NRBP2 Gene

Gene Families for NRBP2 Gene

Protein Domains for NRBP2 Gene


Suggested Antigen Peptide Sequences for NRBP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NSY0
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP2: view

Function for NRBP2 Gene

Molecular function for NRBP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate apoptosis of neural progenitor cells during their differentiation.

Gene Ontology (GO) - Molecular Function for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with NRBP2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRBP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NRBP2 Gene

Localization for NRBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP2 Gene


Subcellular locations from

Jensen Localization Image for NRBP2 Gene COMPARTMENTS Subcellular localization image for NRBP2 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with NRBP2: view

Pathways for NRBP2 Gene

SuperPathways for NRBP2 Gene

No Data Available

Interacting Proteins for NRBP2 Gene

Gene Ontology (GO) - Biological Process for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016242 negative regulation of macroautophagy IMP 22354037
GO:0030182 neuron differentiation ISS --
GO:0043524 negative regulation of neuron apoptotic process ISS --
genes like me logo Genes that share ontologies with NRBP2: view

No data available for Pathways by source for NRBP2 Gene

Transcripts for NRBP2 Gene

Unigene Clusters for NRBP2 Gene

Nuclear receptor binding protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - -
SP4: -
SP5: -

Relevant External Links for NRBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRBP2 Gene

mRNA expression in normal human tissues for NRBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NRBP2 Gene

This gene is overexpressed in Spinal cord (22.1) and Frontal cortex (17.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NRBP2 Gene

SOURCE GeneReport for Unigene cluster for NRBP2 Gene Hs.521926

genes like me logo Genes that share expressions with NRBP2: view

Expression partners for NRBP2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NRBP2 Gene

Orthologs for NRBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NRBP2 35
  • 89.29 (n)
  • 93.45 (a)
NRBP2 36
  • 93 (a)
(Canis familiaris)
Mammalia NRBP2 35
  • 88.15 (n)
  • 92.37 (a)
NRBP2 36
  • 91 (a)
(Pan troglodytes)
Mammalia NRBP2 35
  • 99.2 (n)
  • 100 (a)
NRBP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nrbp2 35
  • 88.34 (n)
  • 95.28 (a)
(Mus musculus)
Mammalia Nrbp2 16
Nrbp2 36
  • 94 (a)
(Monodelphis domestica)
Mammalia NRBP2 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia NRBP2 36
  • 76 (a)
(Gallus gallus)
Aves NRBP2 35
  • 70.11 (n)
  • 68.13 (a)
NRBP2 36
  • 66 (a)
(Anolis carolinensis)
Reptilia NRBP2 36
  • 69 (a)
(Danio rerio)
Actinopterygii nrbp2 35
  • 66.74 (n)
  • 66.1 (a)
nrbp2 36
  • 63 (a)
NRBP2 (1 of 2) 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Madm 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea hpo-11 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 36
  • 38 (a)
Species with no ortholog for NRBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NRBP2 Gene

Gene Tree for NRBP2 (if available)
Gene Tree for NRBP2 (if available)

Paralogs for NRBP2 Gene

Paralogs for NRBP2 Gene

Selected SIMAP similar genes for NRBP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRBP2: view

Variants for NRBP2 Gene

Sequence variations from dbSNP and Humsavar for NRBP2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3866 -- 143,834,573(+) GCAGG(C/G)AGTAT utr-variant-3-prime, intron-variant
rs7465214 -- 143,835,363(+) GCCCC(A/G)GCCAG utr-variant-3-prime, downstream-variant-500B, intron-variant
rs10091644 -- 143,831,703(+) CAGAG(A/G)TAAAT intron-variant
rs10101668 -- 143,843,692(+) aataa(C/G)tttag upstream-variant-2KB
rs11290730 -- 143,843,658(+) ATTTG(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRBP2 Gene

Variant ID Type Subtype PubMed ID
dgv7935n71 CNV Loss 21882294
dgv7939n71 CNV Loss 21882294
dgv7940n71 CNV Loss 21882294
dgv7943n71 CNV Loss 21882294
nsv891766 CNV Loss 21882294
dgv7944n71 CNV Loss 21882294
dgv7945n71 CNV Loss 21882294
dgv7946n71 CNV Loss 21882294
nsv466009 CNV Loss 19166990
nsv891776 CNV Loss 21882294
nsv824782 CNV Gain+Loss 20364138

Relevant External Links for NRBP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP2 Gene

Disorders for NRBP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NRBP2 Gene in MalaCards »

(1) Diseases for NRBP2 Gene including...

(1) University of Copenhagen DISEASES for NRBP2 Gene

genes like me logo Genes that share disorders with NRBP2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for NRBP2 Gene

Publications for NRBP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Nuclear receptor binding protein 2 is induced during neural progenitor differentiation and affects cell survival. (PMID: 18619852) Larsson J. … Forsberg-Nilsson K. (Mol. Cell. Neurosci. 2008) 3
  5. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3

Products for NRBP2 Gene

  • Addgene plasmids for NRBP2

Sources for NRBP2 Gene

Back to Top