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Aliases for NRBP2 Gene

Aliases for NRBP2 Gene

  • Nuclear Receptor Binding Protein 2 2 3 5
  • Transformation-Related Gene 16 Protein 4
  • Nuclear Receptor-Binding Protein 2 3
  • Transformation-Related Protein 16 3
  • Pp9320 3
  • TRG-16 4
  • TRG16 3

External Ids for NRBP2 Gene

Previous GeneCards Identifiers for NRBP2 Gene

  • GC08M144988
  • GC08M144917
  • GC08M140168
  • GC08M144919

Summaries for NRBP2 Gene

GeneCards Summary for NRBP2 Gene

NRBP2 (Nuclear Receptor Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NRBP1.

UniProtKB/Swiss-Prot for NRBP2 Gene

  • May regulate apoptosis of neural progenitor cells during their differentiation.

Additional gene information for NRBP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP2 Gene

Genomics for NRBP2 Gene

Regulatory Elements for NRBP2 Gene

Enhancers for NRBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H144455 1.4 Ensembl ENCODE 12.1 -615.5 -615473 1.6 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 ZNF766 ZNF416 ZNF251 ZNF623 ZNF7 ZNF250 ZNF16 LRRC14 VPS28 CPSF1 ZNF517 ZNF34
GH08H143903 1.2 Ensembl ENCODE dbSUPER 11.6 -63.6 -63593 1.8 PKNOX1 RFX1 SIN3A MNT ELF1 BMI1 RAD21 RFX5 POLR2A HSF1 PLEC MAF1 EPPK1 PUF60 SHARPIN MIR661 NRBP2 SCRIB SPATC1 PARP10
GH08H143905 1.2 ENCODE dbSUPER 11.6 -65.3 -65285 1.5 ELF3 TBP FOXA2 ARID4B SIN3A DMAP1 RAD21 ZBTB7B RARA SLC30A9 PLEC EPPK1 PUF60 MIR661 NRBP2 SCRIB SPATC1 PARP10 EXOSC4 ENSG00000255224
GH08H144002 1.1 Ensembl ENCODE 10.8 -163.5 -163530 3.5 HDAC1 PKNOX1 FOXA2 THRB RAD21 YY1 SCRT2 RCOR1 ATF7 CEBPB PLEC WDR97 EXOSC4 ENSG00000255224 MIR661 GPAA1 CYC1 MAF1 SHARPIN NRBP2
GH08H143010 0.2 dbSUPER 4.5 +829.8 829754 0.5 C8orf31 ENSG00000253715 LY6D NRBP2 LY6E GC08P142999
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRBP2 on UCSC Golden Path with GeneCards custom track

Promoters for NRBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232154 -26 1201 RB1 SIN3A ZBTB40 GLIS2 ATF7 EGR2 SMARCA5 SP3 HCFC1 ELF1

Genomic Locations for NRBP2 Gene

Genomic Locations for NRBP2 Gene
chr8:143,830,016-143,840,974
(GRCh38/hg38)
Size:
10,959 bases
Orientation:
Minus strand
chr8:144,915,755-144,924,200
(GRCh37/hg19)

Genomic View for NRBP2 Gene

Genes around NRBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP2 Gene

Proteins for NRBP2 Gene

  • Protein details for NRBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSY0-NRBP2_HUMAN
    Recommended name:
    Nuclear receptor-binding protein 2
    Protein Accession:
    Q9NSY0
    Secondary Accessions:
    • B4DF59
    • Q2HIX8
    • Q597G7
    • Q8NCX8
    • Q8WYS5

    Protein attributes for NRBP2 Gene

    Size:
    501 amino acids
    Molecular mass:
    57803 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI13874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB70864.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NRBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRBP2 Gene

Post-translational modifications for NRBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NRBP2 Gene

Domains & Families for NRBP2 Gene

Gene Families for NRBP2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NRBP2 Gene

Suggested Antigen Peptide Sequences for NRBP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSY0

UniProtKB/Swiss-Prot:

NRBP2_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP2: view

Function for NRBP2 Gene

Molecular function for NRBP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate apoptosis of neural progenitor cells during their differentiation.

Gene Ontology (GO) - Molecular Function for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NRBP2: view
genes like me logo Genes that share phenotypes with NRBP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRBP2 Gene

Localization for NRBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRBP2 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with NRBP2: view

Pathways & Interactions for NRBP2 Gene

SuperPathways for NRBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA,IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0007399 nervous system development IEA --
GO:0016242 negative regulation of macroautophagy IMP 22354037
GO:0030182 neuron differentiation ISS --
genes like me logo Genes that share ontologies with NRBP2: view

No data available for Pathways by source and SIGNOR curated interactions for NRBP2 Gene

Drugs & Compounds for NRBP2 Gene

No Compound Related Data Available

Transcripts for NRBP2 Gene

Unigene Clusters for NRBP2 Gene

Nuclear receptor binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for NRBP2 Gene

GeneLoc Exon Structure for
NRBP2
ECgene alternative splicing isoforms for
NRBP2

Expression for NRBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRBP2 Gene

Protein differential expression in normal tissues from HIPED for NRBP2 Gene

This gene is overexpressed in Spinal cord (22.1) and Frontal cortex (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRBP2 Gene



Protein tissue co-expression partners for NRBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRBP2 Gene:

NRBP2

SOURCE GeneReport for Unigene cluster for NRBP2 Gene:

Hs.521926

Evidence on tissue expression from TISSUES for NRBP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NRBP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRBP2 Gene

Orthologs for NRBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRBP2 33 34
  • 99.2 (n)
mouse
(Mus musculus)
Mammalia Nrbp2 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRBP2 33 34
  • 89.29 (n)
rat
(Rattus norvegicus)
Mammalia Nrbp2 33
  • 88.34 (n)
dog
(Canis familiaris)
Mammalia NRBP2 33 34
  • 88.15 (n)
oppossum
(Monodelphis domestica)
Mammalia NRBP2 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRBP2 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRBP2 33 34
  • 70.11 (n)
lizard
(Anolis carolinensis)
Reptilia NRBP2 34
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nrbp2 33 34
  • 66.74 (n)
NRBP2 (1 of 2) 34
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Madm 34
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-11 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 34
  • 38 (a)
OneToMany
Species where no ortholog for NRBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NRBP2 Gene

ENSEMBL:
Gene Tree for NRBP2 (if available)
TreeFam:
Gene Tree for NRBP2 (if available)

Paralogs for NRBP2 Gene

Paralogs for NRBP2 Gene

(2) SIMAP similar genes for NRBP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRBP2: view

Variants for NRBP2 Gene

Sequence variations from dbSNP and Humsavar for NRBP2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000035539 -- 143,841,885(+) CCGCT(C/G)TAAGC upstream-variant-2KB
rs1000186951 -- 143,838,538(+) TGAGG(C/T)CCTCT intron-variant, upstream-variant-2KB
rs1000541986 -- 143,829,341(+) CCACT(C/T)TTGCT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1000757052 -- 143,833,693(+) AAATT(G/T)AAAAG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001148691 -- 143,834,209(+) CCTTA(A/G)GGACA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NRBP2 Gene

Variant ID Type Subtype PubMed ID
nsv950014 CNV deletion 24416366
nsv824782 CNV gain+loss 20364138
nsv612897 CNV loss 21841781
nsv612896 CNV loss 21841781
nsv466009 CNV loss 19166990
nsv1161815 CNV deletion 26073780
nsv1077075 CNV deletion 25765185
dgv3931n106 CNV deletion 24896259

Variation tolerance for NRBP2 Gene

Gene Damage Index Score: 3.71; 57.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP2 Gene

Disorders for NRBP2 Gene

Relevant External Links for NRBP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRBP2

No disorders were found for NRBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRBP2 Gene

Publications for NRBP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for NRBP2 Gene

  • Addgene plasmids for NRBP2

Sources for NRBP2 Gene

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