Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NRBP2 Gene

Aliases for NRBP2 Gene

  • Nuclear Receptor Binding Protein 2 2 3 5
  • Transformation-Related Gene 16 Protein 4
  • Nuclear Receptor-Binding Protein 2 3
  • Transformation-Related Protein 16 3
  • Pp9320 3
  • TRG-16 4
  • TRG16 3

External Ids for NRBP2 Gene

Previous GeneCards Identifiers for NRBP2 Gene

  • GC08M144988
  • GC08M144917
  • GC08M140168
  • GC08M144919

Summaries for NRBP2 Gene

GeneCards Summary for NRBP2 Gene

NRBP2 (Nuclear Receptor Binding Protein 2) is a Protein Coding gene. Diseases associated with NRBP2 include Coloboma Of Macula. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NRBP1.

UniProtKB/Swiss-Prot for NRBP2 Gene

  • May regulate apoptosis of neural progenitor cells during their differentiation.

Additional gene information for NRBP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP2 Gene

Genomics for NRBP2 Gene

GeneHancer (GH) Regulatory Elements for NRBP2 Gene

Promoters and enhancers for NRBP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I143841 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 -0.5 -538 2.6 RB1 SIN3A ZBTB40 GLIS2 ZNF143 ATF7 EGR2 SMARCA5 SP3 ZNF280D NRBP2 NAPRT GC08P143837 GC08M143801
GH08I143840 Enhancer 0.4 ENCODE 550.8 +0.9 890 0.2 ZNF311 ZBTB40 PRDM2 NRBP2 GC08P143837 MIR6845 GC08M143801
GH08I144455 Enhancer 1.3 Ensembl ENCODE 12.1 -615.5 -615472 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 POLR2B ZNF766 ZNF251 ZNF623 ZNF7 LRRC14 ZNF250 ZNF16 CPSF1 VPS28 ZNF517 ZNF34
GH08I143905 Enhancer 1.1 ENCODE dbSUPER 11.6 -65.3 -65284 1.5 ELF3 CLOCK FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B RAD21 ZNF48 PLEC EPPK1 PUF60 MIR661 NRBP2 SCRIB SPATC1 PARP10 EXOSC4 ENSG00000255224
GH08I143903 Enhancer 1 Ensembl ENCODE dbSUPER 11.6 -63.6 -63592 1.8 PKNOX1 RFX1 SIN3A MNT ELF1 BMI1 RAD21 RFX5 POLR2A HSF1 PLEC EPPK1 PUF60 MIR661 NRBP2 SCRIB PARP10 SPATC1 EXOSC4 ENSG00000255224
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NRBP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NRBP2 gene promoter:

Genomic Locations for NRBP2 Gene

Genomic Locations for NRBP2 Gene
10,959 bases
Minus strand

Genomic View for NRBP2 Gene

Genes around NRBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP2 Gene

Proteins for NRBP2 Gene

  • Protein details for NRBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear receptor-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DF59
    • Q2HIX8
    • Q597G7
    • Q8NCX8
    • Q8WYS5

    Protein attributes for NRBP2 Gene

    501 amino acids
    Molecular mass:
    57803 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI13874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB70864.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NRBP2 Gene


neXtProt entry for NRBP2 Gene

Post-translational modifications for NRBP2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NRBP2 Gene

Domains & Families for NRBP2 Gene

Gene Families for NRBP2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NRBP2 Gene

Suggested Antigen Peptide Sequences for NRBP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP2: view

Function for NRBP2 Gene

Molecular function for NRBP2 Gene

UniProtKB/Swiss-Prot Function:
May regulate apoptosis of neural progenitor cells during their differentiation.

Phenotypes From GWAS Catalog for NRBP2 Gene

Gene Ontology (GO) - Molecular Function for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NRBP2: view
genes like me logo Genes that share phenotypes with NRBP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRBP2 Gene

Localization for NRBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRBP2 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with NRBP2: view

Pathways & Interactions for NRBP2 Gene

SuperPathways for NRBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA,IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0007399 nervous system development IEA --
GO:0016242 negative regulation of macroautophagy IMP 22354037
GO:0030182 neuron differentiation ISS --
genes like me logo Genes that share ontologies with NRBP2: view

No data available for Pathways by source and SIGNOR curated interactions for NRBP2 Gene

Drugs & Compounds for NRBP2 Gene

No Compound Related Data Available

Transcripts for NRBP2 Gene

Unigene Clusters for NRBP2 Gene

Nuclear receptor binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - -
SP4: -
SP5: -

Relevant External Links for NRBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRBP2 Gene

Protein differential expression in normal tissues from HIPED for NRBP2 Gene

This gene is overexpressed in Spinal cord (22.1) and Frontal cortex (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRBP2 Gene

Protein tissue co-expression partners for NRBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NRBP2 Gene:


SOURCE GeneReport for Unigene cluster for NRBP2 Gene:


Evidence on tissue expression from TISSUES for NRBP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NRBP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRBP2 Gene

Orthologs for NRBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NRBP2 33 34
  • 99.2 (n)
(Mus musculus)
Mammalia Nrbp2 34
  • 94 (a)
(Bos Taurus)
Mammalia NRBP2 34 33
  • 89.29 (n)
(Rattus norvegicus)
Mammalia Nrbp2 33
  • 88.34 (n)
(Canis familiaris)
Mammalia NRBP2 34 33
  • 88.15 (n)
(Monodelphis domestica)
Mammalia NRBP2 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia NRBP2 34
  • 76 (a)
(Gallus gallus)
Aves NRBP2 34 33
  • 70.11 (n)
(Anolis carolinensis)
Reptilia NRBP2 34
  • 69 (a)
(Danio rerio)
Actinopterygii nrbp2 33 34
  • 66.74 (n)
NRBP2 (1 of 2) 34
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Madm 34
  • 38 (a)
(Caenorhabditis elegans)
Secernentea hpo-11 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 34
  • 38 (a)
Species where no ortholog for NRBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NRBP2 Gene

Gene Tree for NRBP2 (if available)
Gene Tree for NRBP2 (if available)

Paralogs for NRBP2 Gene

Paralogs for NRBP2 Gene

(2) SIMAP similar genes for NRBP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRBP2: view

Variants for NRBP2 Gene

Sequence variations from dbSNP and Humsavar for NRBP2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1064795388 likely-pathogenic, not provided 143,829,279(-) C/T downstream_transcript_variant
rs1000186951 -- 143,838,538(-) T/C intron_variant
rs1000541986 -- 143,829,341(-) C/T downstream_transcript_variant
rs1000757052 -- 143,833,693(-) T/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001148691 -- 143,834,209(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NRBP2 Gene

Variant ID Type Subtype PubMed ID
dgv3931n106 CNV deletion 24896259
nsv1077075 CNV deletion 25765185
nsv1161815 CNV deletion 26073780
nsv466009 CNV loss 19166990
nsv612896 CNV loss 21841781
nsv612897 CNV loss 21841781
nsv824782 CNV gain+loss 20364138
nsv950014 CNV deletion 24416366

Variation tolerance for NRBP2 Gene

Gene Damage Index Score: 3.71; 57.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NRBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP2 Gene

Disorders for NRBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
coloboma of macula
  • agenesis of macula
- elite association - COSMIC cancer census association via MalaCards
Search NRBP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NRBP2

genes like me logo Genes that share disorders with NRBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRBP2 Gene

Publications for NRBP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for NRBP2 Gene

  • Addgene plasmids for NRBP2

Sources for NRBP2 Gene

Loading form....