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NRBP1 Gene

protein-coding   GIFtS: 59
GCID: GC02P027651

Nuclear Receptor Binding Protein 1

(Previous name: nuclear receptor binding protein)
(Previous symbol: NRBP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Binding Protein 11 2     MUDPNP2
NRBP1 2 3 5     Multiple Domain Putative Nuclear Protein2
BCON32 3     Myeloid Leukemia Factor 1 Adaptor Molecule2
Nuclear Receptor Binding Protein1     Nuclear Receptor-Binding Protein2
MADM2     

External Ids:    HGNC: 79931   Entrez Gene: 299592   Ensembl: ENSG000001152167   OMIM: 6060105   UniProtKB: Q9UHY13   

Export aliases for NRBP1 gene to outside databases

Previous GC identifers: GC02P027563 GC02P027504 GC02P027393


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NRBP1 Gene:
NRBP1 (nuclear receptor binding protein 1) is a protein-coding gene. Diseases associated with NRBP1 include bell's palsy, and drug addiction. GO annotations related to this gene include protein kinase activity and protein homodimerization activity. An important paralog of this gene is WNK1.

UniProtKB/Swiss-Prot: NRBP_HUMAN, Q9UHY1
Function: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through
interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this
activity into the alteration of the intracellular membrane structure associated with flaviviral replication

Gene Wiki entry for NRBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRBP1 gene promoter:
         ER-alpha   AhR   AML1a   AP-1   NRSF form 1   ATF-2   NRSF form 2   Arnt   PPAR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRBP1 promoter sequence
   Search Chromatin IP Primers for NRBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

NRBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRBP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027651:  view genomic region     (about GC identifiers)

Start:
27,650,657 bp from pter      End:
27,665,126 bp from pter
Size:
14,470 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NRBP_HUMAN, Q9UHY1 (See protein sequence)
Recommended Name: Nuclear receptor-binding protein  
Size: 535 amino acids; 59845 Da
Subunit: Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1.
Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity)
Caution: Author states that kinase activity observed in PubMed:11956649 may be due to sample contamination. This
protein is predicted to be catalytically inactive
Secondary accessions: B3KV40 D6W558 Q53FZ5 Q96SU3

Explore the universe of human proteins at neXtProt for NRBP1: NX_Q9UHY1

Explore proteomics data for NRBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys517
  • Modification sites at PhosphoSitePlus

  • See NRBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037524.1  
    ENSEMBL proteins: 
     ENSP00000233557   ENSP00000369181   ENSP00000369192   ENSP00000403916   ENSP00000415406  
    Reactome Protein details: Q9UHY1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: nuclear receptor binding protein 1
    NRBP family

    2 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UHY1

    ProtoNet protein and cluster: Q9UHY1

    UniProtKB/Swiss-Prot: NRBP_HUMAN, Q9UHY1
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    NRBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRBP_HUMAN, Q9UHY1
    Function: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through
    interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this
    activity into the alteration of the intracellular membrane structure associated with flaviviral replication

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11956649
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    NRBP1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NRBP1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nrbp1):
     cellular  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 
     mortality/aging  tumorigenesis 

    NRBP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nrbp1tm1.2Dja for NRBP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRBP1
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    miRNA
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    miRTarBase miRNAs that target NRBP1:
    hsa-mir-320a (MIRT044641), hsa-mir-339-5p (MIRT042756), hsa-mir-196a-5p (MIRT048204), hsa-mir-181b-5p (MIRT047260), hsa-mir-615-3p (MIRT040406), hsa-mir-26b-5p (MIRT029933), hsa-mir-375 (MIRT019893)

    Block miRNA regulation of human, mouse, rat NRBP1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NRBP1:
    hsa-miR-548p hsa-miR-200c hsa-miR-19b hsa-miR-429 hsa-miR-200b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidNRBP1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRBP_HUMAN, Q9UHY1: Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium.
    Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005938cell cortex IEA--
    GO:0012505endomembrane system IDA11956649
    GO:0016020membrane IEA--
    GO:0030027lamellipodium IEA--

    NRBP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NRBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    2Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NRBP1
        Nuclear Receptor transcription pathway



    NRBP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRBP1
    Interactions:

        Search GeneGlobe Interaction Network for NRBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NRBP1 (Q9UHY11, 2, 3 ENSP000002335574) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253484 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253484 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253484 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253484 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253484 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006468protein phosphorylation ----
    GO:0006888ER to Golgi vesicle-mediated transport IDA11956649
    GO:0010467gene expression TAS--

    NRBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRBP1 (NRBP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NRBP1 gene: 
    NM_013392.2  

    Unigene Cluster for NRBP1:

    Nuclear receptor binding protein 1
    Hs.515876  [show with all ESTs]
    Unigene Representative Sequence: AK122664
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233557(uc002rko.3 uc002rkp.3) ENST00000379852 ENST00000379863
    ENST00000419281 ENST00000356442 ENST00000493768 ENST00000493746 ENST00000460499(uc002rkr.3)
    ENST00000486701
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate NRBP1:
    hsa-miR-548p hsa-miR-200c hsa-miR-19b hsa-miR-429 hsa-miR-200b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidNRBP1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NRBP1 (NM_013392)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRBP1
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      QuantiFast Probe-based Assays in human, mouse, rat NRBP1

    Additional mRNA sequence: 

    AF113249.1 AK001946.1 AK027538.1 AK092860.1 AK122664.1 AK130619.1 AK223136.1 AK225540.1 
    AK301345.1 AL136682.1 BC001221.1 

    Selected DOTS entries (see all 27):

    DT.451391  DT.100679188  DT.100679183  DT.91641576  DT.95267243  DT.100679190  DT.100848260  DT.120989375 
    DT.120989394  DT.91974962  DT.92455969  DT.95297167  DT.100054484  DT.100059602  DT.100679192  DT.120989392 
    DT.120989418  DT.120989423  DT.92455947  DT.92455963  DT.92455968  DT.95084926  DT.95267237  DT.95267267 

    Selected AceView cDNA sequences (see all 529):

    CA418068 BM681787 BQ225378 AI697118 BM453441 BU508281 BP378554 BI765284 
    AW050898 BU174877 BM803867 BQ929838 AA320390 BM741542 CA441364 AI187729 
    AU279982 BP378383 BP374643 BF437012 BC001221 BU197037 BU180443 AI284294 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NRBP1 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^
    SP1:                                            -                                         -                                         -                 -         
    SP2:                                            -                                         -                                         -                 -         
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                  -         
    SP5:                                                                                      -                                         -                 -         

    ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
    SP1:        -                       -                                         -               
    SP2:        -                       -                                         -               
    SP3:        -                       -                                         -               
    SP4:        -           -     -     -     -                                   -               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NRBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATACTAGTG
    NRBP1 Expression
    About this image


    NRBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    NRBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515876

    UniProtKB/Swiss-Prot: NRBP_HUMAN, Q9UHY1
    Tissue specificity: Ubiquitously expressed in all tissues examined with high levels in the testis

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NRBP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrbp11 , 5 nuclear receptor binding protein 11, 5 93.27(n)1
    98.32(a)1
      5 (17.27 cM)5
    1922921  NM_147201.21  NP_671734.11 
     312408645 
    chicken
    (Gallus gallus)
    Aves NRBP11 nuclear receptor binding protein 1 76.69(n)
    88.16(a)
      421985  NM_001006420.1  NP_001006420.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRBP16
    nuclear receptor binding protein 1
    94(a)
    1 ↔ 1
    GL344394.1(11477-30896)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.62762 Xenopus laevis transcribed sequence with strong similarity more 82.06(n)    BU910154.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.131702 Transcribed sequence with moderate similarity to protein more 79.81(n)    57089800 
    fruit fly
    (Drosophila melanogaster)
    Insecta Madm1 MLF1-adaptor molecule 56.54(n)
    53.16(a)
      40710  NM_141324.2  NP_649581.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-116
    Protein HPO-11 (hpo-11) mRNA, complete cds
    38(a)
    1 → many
    I(7140278-7147230) WBGene00010427


    ENSEMBL Gene Tree for NRBP1 (if available)
    TreeFam Gene Tree for NRBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRBP1 gene
    WNK12  WNK42  WNK22  NRBP22  WNK32  
    2 SIMAP similar genes for NRBP1 using alignment to 4 protein entries:     NRBP_HUMAN (see all proteins):
    NRBP2    WNK4

    NRBP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRBP1 (see all 257)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413604
    An ovarian mucinous carcinoma sample4--see VAR_0413602 P L mis40--------
    rs1847674171,2
    --27649482(+) AAAGCA/GGAAGG 1 -- us2k10--------
    rs717242681,2
    C--27649527(+) GGAAACT/-CTAAT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1895795801,2
    --27649568(+) TTACCC/TTGGGC 1 -- us2k10--------
    rs1807068771,2
    --27649643(+) ACCAAG/TAAATT 1 -- us2k10--------
    rs1852296661,2
    --27649731(+) TCAGCC/TAACAG 1 -- us2k10--------
    rs17289111,2
    C,A--27649929(-) gtaatC/Accagc 1 -- us2k12Minor allele frequency- A:0.00CSA 2
    rs65476281,2
    C,A--27650180(+) tatatA/Tttttt 1 -- us2k1 tfbs3 trp30--------
    rs1395490021,2
    --27650228(+) ACACTC/TTGTTG 1 -- us2k10--------
    rs1450764231,2
    --27650293(+) GGCTCA/GAGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NRBP1 (27650657 - 27665126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NRBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267441CNV Insertion20981092
    nsv873754CNV Loss21882294
    nsv817684CNV Gain17921354
    nsv833614CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NRBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for NRBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606010    OMIM disorders: --

    7 diseases for NRBP1:    
    About MalaCards
    bell's palsy    drug addiction    myeloid leukemia    leukemia
    prostate cancer    prostatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for NRBP1:
    Bell's palsy

    NRBP1 for disorders           About GeneDecksing


    Export disorders for NRBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRBP1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with NRBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. (PubMed id 11956649)1, 2, 3, 9 De Langhe S.... Heisterkamp N. (Int. J. Mol. Med. 2002)
    2. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. (PubMed id 10843813)1, 2, 3 Hooper J.D.... Antalis T.M. (Genomics 2000)
    3. The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure. (PubMed id 15084397)1, 2, 9 Chua J.J.E.... Chow V.T.K. (Virus Res. 2004)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. (PubMed id 17052710)1, 9 Wang H....Wu J. (FEBS Lett. 2006)
    10. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (J. Med. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29959 HGNC: 7993 AceView: NRBP Ensembl:ENSG00000115216 euGenes: HUgn29959
    ECgene: NRBP1 H-InvDB: NRBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NRBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NRBP1 gene:
    Search GeneIP for patents involving NRBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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