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Aliases for NRBP1 Gene

Aliases for NRBP1 Gene

  • Nuclear Receptor Binding Protein 1 2 3 5
  • BCON3 3 4
  • NRBP 3 4
  • Myeloid Leukemia Factor 1 Adaptor Molecule 3
  • Multiple Domain Putative Nuclear Protein 3
  • Nuclear Receptor Binding Protein 2
  • Nuclear Receptor-Binding Protein 3
  • MUDPNP 3
  • MADM 3

External Ids for NRBP1 Gene

Previous HGNC Symbols for NRBP1 Gene

  • NRBP

Previous GeneCards Identifiers for NRBP1 Gene

  • GC02P027563
  • GC02P027504
  • GC02P027651

Summaries for NRBP1 Gene

GeneCards Summary for NRBP1 Gene

NRBP1 (Nuclear Receptor Binding Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is NRBP2.

UniProtKB/Swiss-Prot for NRBP1 Gene

  • May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Gene Wiki entry for NRBP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP1 Gene

Genomics for NRBP1 Gene

Regulatory Elements for NRBP1 Gene

Enhancers for NRBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G026562 1.4 Ensembl ENCODE 26.1 -865.0 -864975 1.3 HDGF FOXA2 PKNOX1 ARNT CREB3L1 MLX AGO1 ZFP64 ARID4B SIN3A GTF3C2 NRBP1 CAD GTF3C2-AS1 LOC105374363 SNX17 PPM1G KCNK3 HADHA OST4
GH02G026717 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 13.2 -705.5 -705536 10.1 HDGF FOXA2 MLX CREB3L1 SIN3A DMAP1 YY1 ZNF766 FOS ZNF263 CENPA GPN1 CAD LOC105374363 ZNF512 NRBP1 GTF3C2-AS1 KCNK3 SLC35F6 ENSG00000235267
GH02G026754 2 FANTOM5 Ensembl ENCODE dbSUPER 12 -670.4 -670381 5.8 HDGF FOXA2 PKNOX1 ARNT ZFP64 SIN3A ARID4B YY1 SLC30A9 ZNF766 NRBP1 KCNK3 KHK GPN1 SLC35F6 GC02P026705
GH02G027183 1.3 Ensembl ENCODE 17.1 -242.7 -242736 2.8 PKNOX1 FOXA2 ARID4B SIN3A ZNF48 YY1 GLIS2 CBX5 ZNF207 ZNF263 GTF3C2 SNX17 GPN1 ZNF512 NRBP1 CAD GTF3C2-AS1 ATRAID LOC105374363 ENSG00000236099
GH02G027069 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -351.3 -351297 14.9 MLX CREB3L1 AGO1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 KHK SNX17 ZNF512 CAD GTF3C2 ENSG00000235267 GPN1 OST4 HADHA NRBP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRBP1 on UCSC Golden Path with GeneCards custom track

Promoters for NRBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114423 1310 2201 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for NRBP1 Gene

Chromosome:
2
Start:
27,427,790 bp from pter
End:
27,442,259 bp from pter
Size:
14,470 bases
Orientation:
Plus strand

Genomic View for NRBP1 Gene

Genes around NRBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP1 Gene

Proteins for NRBP1 Gene

  • Protein details for NRBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHY1-NRBP_HUMAN
    Recommended name:
    Nuclear receptor-binding protein
    Protein Accession:
    Q9UHY1
    Secondary Accessions:
    • B3KV40
    • D6W558
    • Q53FZ5
    • Q96SU3

    Protein attributes for NRBP1 Gene

    Size:
    535 amino acids
    Molecular mass:
    59845 Da
    Quaternary structure:
    • Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity).

neXtProt entry for NRBP1 Gene

Post-translational modifications for NRBP1 Gene

  • Ubiquitination at posLast=517517
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRBP1 Gene

Domains & Families for NRBP1 Gene

Gene Families for NRBP1 Gene

Protein Domains for NRBP1 Gene

Suggested Antigen Peptide Sequences for NRBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHY1

UniProtKB/Swiss-Prot:

NRBP_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP1: view

Function for NRBP1 Gene

Molecular function for NRBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Gene Ontology (GO) - Molecular Function for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 11956649
GO:0005524 ATP binding IEA --
GO:0042802 identical protein binding IEA --
GO:0042803 protein homodimerization activity ISS,IEA --
genes like me logo Genes that share ontologies with NRBP1: view
genes like me logo Genes that share phenotypes with NRBP1: view

Animal Models for NRBP1 Gene

MGI Knock Outs for NRBP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NRBP1

CRISPR Products

miRNA for NRBP1 Gene

miRTarBase miRNAs that target NRBP1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NRBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRBP1 Gene

Localization for NRBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP1 Gene

Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRBP1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
GO:0005938 cell cortex IEA --
GO:0012505 endomembrane system IDA,IEA 11956649
genes like me logo Genes that share ontologies with NRBP1: view

Pathways & Interactions for NRBP1 Gene

genes like me logo Genes that share pathways with NRBP1: view

Pathways by source for NRBP1 Gene

Gene Ontology (GO) - Biological Process for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IBA,IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IDA 11956649
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with NRBP1: view

No data available for SIGNOR curated interactions for NRBP1 Gene

Drugs & Compounds for NRBP1 Gene

No Compound Related Data Available

Transcripts for NRBP1 Gene

Unigene Clusters for NRBP1 Gene

Nuclear receptor binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NRBP1

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13: -

ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for NRBP1 Gene

GeneLoc Exon Structure for
NRBP1
ECgene alternative splicing isoforms for
NRBP1

Expression for NRBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NRBP1 Gene

Protein differential expression in normal tissues from HIPED for NRBP1 Gene

This gene is overexpressed in Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRBP1 Gene



Protein tissue co-expression partners for NRBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRBP1 Gene:

NRBP1

SOURCE GeneReport for Unigene cluster for NRBP1 Gene:

Hs.515876

mRNA Expression by UniProt/SwissProt for NRBP1 Gene:

Q9UHY1-NRBP_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined with high levels in the testis.

Evidence on tissue expression from TISSUES for NRBP1 Gene

  • Nervous system(4.9)
  • Blood(4.2)
  • Pancreas(3.5)
  • Lung(2.9)
  • Skin(2.4)
  • Kidney(2.2)
  • Heart(2)
  • Liver(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with NRBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NRBP1 Gene

Orthologs for NRBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRBP1 35 34
  • 99.63 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRBP1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRBP1 35 34
  • 95.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NRBP1 35 34
  • 95.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nrbp1 16 35 34
  • 93.27 (n)
rat
(Rattus norvegicus)
Mammalia Nrbp1 34
  • 92.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NRBP1 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRBP1 35 34
  • 76.69 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRBP1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrbp1 34
  • 77.31 (n)
Str.6647 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6276 34
zebrafish
(Danio rerio)
Actinopterygii nrbp1 35 34
  • 73.7 (n)
OneToOne
Dr.13170 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9281 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007996 34
  • 59.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta Madm 34 35
  • 56.54 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-11 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 35
  • 48 (a)
OneToMany
Species where no ortholog for NRBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRBP1 Gene

ENSEMBL:
Gene Tree for NRBP1 (if available)
TreeFam:
Gene Tree for NRBP1 (if available)

Paralogs for NRBP1 Gene

Paralogs for NRBP1 Gene

(2) SIMAP similar genes for NRBP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRBP1: view

Variants for NRBP1 Gene

Sequence variations from dbSNP and Humsavar for NRBP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs753734841 An ovarian mucinous carcinoma sample 27,440,906(+) GACTC(C/T)GACAC upstream-variant-2KB, reference, missense
rs1000116662 -- 27,440,521(+) ACTGA(A/G)AGGGT intron-variant, upstream-variant-2KB
rs1000286482 -- 27,437,022(+) ATTAA(-/C)CAAAG intron-variant
rs1000431434 -- 27,432,522(+) TGCCT(A/G)GCCTG intron-variant
rs1000436881 -- 27,426,527(+) TTGAT(A/C)ATTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRBP1 Gene

Variant ID Type Subtype PubMed ID
esv3325195 CNV insertion 20981092
nsv1116367 CNV deletion 24896259
nsv581244 CNV loss 21841781
nsv817684 CNV gain 17921354
nsv833614 CNV gain 17160897

Variation tolerance for NRBP1 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP1 Gene

Disorders for NRBP1 Gene

Relevant External Links for NRBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRBP1

No disorders were found for NRBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRBP1 Gene

Publications for NRBP1 Gene

  1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. (PMID: 11956649) De Langhe S. … Heisterkamp N. (Int. J. Mol. Med. 2002) 2 3 4 22 64
  2. The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure. (PMID: 15084397) Chua J.J.E. … Chow V.T.K. (Virus Res. 2004) 3 4 22 64
  3. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. (PMID: 10843813) Hooper J.D. … Antalis T.M. (Genomics 2000) 2 3 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. (PMID: 17052710) Wang H. … Wu J. (FEBS Lett. 2006) 3 22 64

Products for NRBP1 Gene

  • Addgene plasmids for NRBP1

Sources for NRBP1 Gene

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