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Aliases for NRBP1 Gene

Aliases for NRBP1 Gene

  • Nuclear Receptor Binding Protein 1 2 3 5
  • BCON3 3 4
  • NRBP 3 4
  • Myeloid Leukemia Factor 1 Adaptor Molecule 3
  • Multiple Domain Putative Nuclear Protein 3
  • Nuclear Receptor Binding Protein 2
  • MUDPNP 3
  • MADM 3

External Ids for NRBP1 Gene

Previous HGNC Symbols for NRBP1 Gene

  • NRBP

Previous GeneCards Identifiers for NRBP1 Gene

  • GC02P027563
  • GC02P027504
  • GC02P027651

Summaries for NRBP1 Gene

GeneCards Summary for NRBP1 Gene

NRBP1 (Nuclear Receptor Binding Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is WNK4.

UniProtKB/Swiss-Prot for NRBP1 Gene

  • May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Gene Wiki entry for NRBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP1 Gene

Genomics for NRBP1 Gene

Regulatory Elements for NRBP1 Gene

Promoters for NRBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRBP1 Gene

Chromosome:
2
Start:
27,427,790 bp from pter
End:
27,442,259 bp from pter
Size:
14,470 bases
Orientation:
Plus strand

Genomic View for NRBP1 Gene

Genes around NRBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP1 Gene

Proteins for NRBP1 Gene

  • Protein details for NRBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHY1-NRBP_HUMAN
    Recommended name:
    Nuclear receptor-binding protein
    Protein Accession:
    Q9UHY1
    Secondary Accessions:
    • B3KV40
    • D6W558
    • Q53FZ5
    • Q96SU3

    Protein attributes for NRBP1 Gene

    Size:
    535 amino acids
    Molecular mass:
    59845 Da
    Quaternary structure:
    • Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity).

neXtProt entry for NRBP1 Gene

Proteomics data for NRBP1 Gene at MOPED

Post-translational modifications for NRBP1 Gene

  • Ubiquitination at Lys 517
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NRBP1 Gene

Domains & Families for NRBP1 Gene

Gene Families for NRBP1 Gene

Protein Domains for NRBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHY1

UniProtKB/Swiss-Prot:

NRBP_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP1: view

Function for NRBP1 Gene

Molecular function for NRBP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Gene Ontology (GO) - Molecular Function for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NRBP1: view
genes like me logo Genes that share phenotypes with NRBP1: view

Animal Models for NRBP1 Gene

MGI Knock Outs for NRBP1:

Animal Model Products

CRISPR Products

miRNA for NRBP1 Gene

miRTarBase miRNAs that target NRBP1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRBP1 Gene

Localization for NRBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP1 Gene

Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRBP1 Gene COMPARTMENTS Subcellular localization image for NRBP1 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with NRBP1: view

Pathways & Interactions for NRBP1 Gene

genes like me logo Genes that share pathways with NRBP1: view

Pathways by source for NRBP1 Gene

Gene Ontology (GO) - Biological Process for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IEA,IBA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NRBP1: view

No data available for SIGNOR curated interactions for NRBP1 Gene

Drugs & Compounds for NRBP1 Gene

No Compound Related Data Available

Transcripts for NRBP1 Gene

Unigene Clusters for NRBP1 Gene

Nuclear receptor binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13: -

ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for NRBP1 Gene

GeneLoc Exon Structure for
NRBP1
ECgene alternative splicing isoforms for
NRBP1

Expression for NRBP1 Gene

mRNA expression in normal human tissues for NRBP1 Gene

Protein differential expression in normal tissues from HIPED for NRBP1 Gene

This gene is overexpressed in Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRBP1 Gene



SOURCE GeneReport for Unigene cluster for NRBP1 Gene Hs.515876

mRNA Expression by UniProt/SwissProt for NRBP1 Gene

Q9UHY1-NRBP_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined with high levels in the testis.
genes like me logo Genes that share expression patterns with NRBP1: view

Protein tissue co-expression partners for NRBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NRBP1 Gene

Orthologs for NRBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRBP1 35
  • 95.14 (n)
  • 99.63 (a)
NRBP1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRBP1 35
  • 95.83 (n)
  • 99.63 (a)
NRBP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrbp1 35
  • 93.27 (n)
  • 98.32 (a)
Nrbp1 16
Nrbp1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRBP1 35
  • 99.63 (n)
  • 100 (a)
NRBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrbp1 35
  • 92.9 (n)
  • 99.25 (a)
oppossum
(Monodelphis domestica)
Mammalia NRBP1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRBP1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRBP1 35
  • 76.69 (n)
  • 88.16 (a)
NRBP1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRBP1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrbp1 35
  • 77.31 (n)
  • 88.02 (a)
Str.6647 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6276 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13170 35
nrbp1 35
  • 73.7 (n)
  • 83.84 (a)
nrbp1 36
  • 84 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9281 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007996 35
  • 59.91 (n)
  • 62.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Madm 35
  • 56.54 (n)
  • 53.16 (a)
Madm 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-11 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 36
  • 48 (a)
OneToMany
Species with no ortholog for NRBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRBP1 Gene

ENSEMBL:
Gene Tree for NRBP1 (if available)
TreeFam:
Gene Tree for NRBP1 (if available)

Paralogs for NRBP1 Gene

Paralogs for NRBP1 Gene

(2) SIMAP similar genes for NRBP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRBP1: view

Variants for NRBP1 Gene

Sequence variations from dbSNP and Humsavar for NRBP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_041359 -
VAR_041360 An ovarian mucinous carcinoma sample
VAR_041361 -
rs704791 -- 27,434,300(+) GCTTC(C/T)TTCTT intron-variant
rs809673 -- 27,433,169(+) ccacc(A/G)cgtcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRBP1 Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
nsv817684 CNV Gain 17921354
esv267441 CNV Insertion 20981092

Variation tolerance for NRBP1 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRBP1 Gene

HapMap Linkage Disequilibrium report
NRBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP1 Gene

Disorders for NRBP1 Gene

Relevant External Links for NRBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRBP1

No disorders were found for NRBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRBP1 Gene

Publications for NRBP1 Gene

  1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. (PMID: 11956649) De Langhe S. … Heisterkamp N. (Int. J. Mol. Med. 2002) 2 3 4 23 67
  2. Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. (PMID: 17052710) Wang H. … Wu J. (FEBS Lett. 2006) 3 23
  3. The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure. (PMID: 15084397) Chua J.J.E. … Chow V.T.K. (Virus Res. 2004) 3 23
  4. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. (PMID: 10843813) Hooper J.D. … Antalis T.M. (Genomics 2000) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NRBP1 Gene

Sources for NRBP1 Gene

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