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Aliases for NRBP1 Gene

Aliases for NRBP1 Gene

  • Nuclear Receptor Binding Protein 1 2 3
  • NRBP 3 4 6
  • BCON3 3 4
  • Myeloid Leukemia Factor 1 Adaptor Molecule 3
  • Multiple Domain Putative Nuclear Protein 3
  • Nuclear Receptor Binding Protein 2
  • Nuclear Receptor-Binding Protein 3
  • MUDPNP 3
  • MADM 3

External Ids for NRBP1 Gene

Previous HGNC Symbols for NRBP1 Gene

  • NRBP

Previous GeneCards Identifiers for NRBP1 Gene

  • GC02P027563
  • GC02P027504
  • GC02P027651

Summaries for NRBP1 Gene

GeneCards Summary for NRBP1 Gene

NRBP1 (Nuclear Receptor Binding Protein 1) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is WNK4.

UniProtKB/Swiss-Prot for NRBP1 Gene

  • May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Gene Wiki entry for NRBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBP1 Gene

Genomics for NRBP1 Gene

Regulatory Elements for NRBP1 Gene

Genomic Location for NRBP1 Gene

Start:
27,427,790 bp from pter
End:
27,442,259 bp from pter
Size:
14,470 bases
Orientation:
Plus strand

Genomic View for NRBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBP1 Gene

Proteins for NRBP1 Gene

  • Protein details for NRBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHY1-NRBP_HUMAN
    Recommended name:
    Nuclear receptor-binding protein
    Protein Accession:
    Q9UHY1
    Secondary Accessions:
    • B3KV40
    • D6W558
    • Q53FZ5
    • Q96SU3

    Protein attributes for NRBP1 Gene

    Size:
    535 amino acids
    Molecular mass:
    59845 Da
    Quaternary structure:
    • Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity).

neXtProt entry for NRBP1 Gene

Proteomics data for NRBP1 Gene at MOPED

Post-translational modifications for NRBP1 Gene

  • Ubiquitination at Lys517
  • Modification sites at PhosphoSitePlus

Other Protein References for NRBP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NRBP1 Gene

Domains for NRBP1 Gene

Gene Families for NRBP1 Gene

Protein Domains for NRBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHY1

UniProtKB/Swiss-Prot:

NRBP_HUMAN :
  • Q9UHY1
Domain:
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NRBP1: view

Function for NRBP1 Gene

Molecular function for NRBP1 Gene

UniProtKB/Swiss-Prot Function: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Gene Ontology (GO) - Molecular Function for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 11956649
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with NRBP1: view
genes like me logo Genes that share phenotypes with NRBP1: view

Animal Models for NRBP1 Gene

MGI Knock Outs for NRBP1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NRBP1 Gene

Localization for NRBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBP1 Gene

Cytoplasm, cell cortex. Endomembrane system. Cell projection, lamellipodium. Note=Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRBP1 Gene COMPARTMENTS Subcellular localization image for NRBP1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005938 cell cortex IEA --
GO:0012505 endomembrane system IDA 11956649
GO:0016020 membrane IEA --
GO:0030027 lamellipodium IEA --
genes like me logo Genes that share ontologies with NRBP1: view

Pathways for NRBP1 Gene

genes like me logo Genes that share pathways with NRBP1: view

Pathways by source for NRBP1 Gene

Gene Ontology (GO) - Biological Process for NRBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IDA 11956649
GO:0008152 metabolic process --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NRBP1: view

Transcripts for NRBP1 Gene

Unigene Clusters for NRBP1 Gene

Nuclear receptor binding protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRBP1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRBP1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13: -

ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for NRBP1 Gene

GeneLoc Exon Structure for
NRBP1
ECgene alternative splicing isoforms for
NRBP1

Expression for NRBP1 Gene

mRNA expression in normal human tissues for NRBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRBP1 Gene

SOURCE GeneReport for Unigene cluster for NRBP1 Gene Hs.515876

mRNA Expression by UniProt/SwissProt for NRBP1 Gene

Q9UHY1-NRBP_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined with high levels in the testis.
genes like me logo Genes that share expressions with NRBP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NRBP1 Gene

Orthologs for NRBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NRBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRBP1 35
  • 99.63 (n)
  • 100 (a)
NRBP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRBP1 35
  • 95.14 (n)
  • 99.63 (a)
NRBP1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRBP1 35
  • 95.83 (n)
  • 99.63 (a)
NRBP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrbp1 35
  • 93.27 (n)
  • 98.32 (a)
Nrbp1 16
Nrbp1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRBP1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRBP1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrbp1 35
  • 92.9 (n)
  • 99.25 (a)
chicken
(Gallus gallus)
Aves NRBP1 35
  • 76.69 (n)
  • 88.16 (a)
NRBP1 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRBP1 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6276 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nrbp1 35
  • 77.31 (n)
  • 88.02 (a)
Str.6647 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9281 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13170 35
nrbp1 35
  • 73.7 (n)
  • 83.84 (a)
nrbp1 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007996 35
  • 59.91 (n)
  • 62.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Madm 35
  • 56.54 (n)
  • 53.16 (a)
Madm 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-11 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5793 36
  • 48 (a)
OneToMany
Species with no ortholog for NRBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRBP1 Gene

ENSEMBL:
Gene Tree for NRBP1 (if available)
TreeFam:
Gene Tree for NRBP1 (if available)

Paralogs for NRBP1 Gene

Paralogs for NRBP1 Gene

Selected SIMAP similar genes for NRBP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRBP1: view

Variants for NRBP1 Gene

Sequence variations from dbSNP and Humsavar for NRBP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs704791 -- 27,434,300(+) GCTTC(C/T)TTCTT intron-variant
rs780100 -- 27,429,286(+) TTCTA(G/T)GGGCC intron-variant
rs780101 -- 27,430,469(+) TTTTT(C/T)TTTTT intron-variant
rs780102 -- 27,436,624(+) GAATA(C/T)GTTTG intron-variant, utr-variant-3-prime
rs780103 -- 27,438,153(+) CCAGC(C/G/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRBP1 Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
nsv817684 CNV Gain 17921354
esv267441 CNV Insertion 20981092

Relevant External Links for NRBP1 Gene

HapMap Linkage Disequilibrium report
NRBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBP1 Gene

Disorders for NRBP1 Gene

(1) University of Copenhagen DISEASES for NRBP1 Gene

genes like me logo Genes that share disorders with NRBP1: view

No data available for UniProtKB/Swiss-Prot for NRBP1 Gene

Publications for NRBP1 Gene

  1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. (PMID: 11956649) De Langhe S. … Heisterkamp N. (Int. J. Mol. Med. 2002) 2 3 4 23
  2. The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure. (PMID: 15084397) Chua J.J.E. … Chow V.T.K. (Virus Res. 2004) 3 4 23
  3. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. (PMID: 10843813) Hooper J.D. … Antalis T.M. (Genomics 2000) 2 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. (PMID: 17052710) Wang H. … Wu J. (FEBS Lett. 2006) 3 23

Products for NRBP1 Gene

  • Addgene plasmids for NRBP1

Sources for NRBP1 Gene

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