Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NRBF2 Gene

protein-coding   GIFtS: 51
GCID: GC10P064893

Nuclear Receptor Binding Factor 2

  Search for NRBF2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Receptor Binding Factor 21 2     COPR22
Comodulator Of PPAR And RXR 11 2     Nuclear Receptor Binding Factor-22
Comodulator Of PPAR And RXR 21 2     Nuclear Receptor-Binding Factor 22
NRBF-22 3     COPR3
COPR12     Comodulator Of PPAR And RXR3

External Ids:    HGNC: 196921   Entrez Gene: 299822   Ensembl: ENSG000001485727   UniProtKB: Q96F243   

Export aliases for NRBF2 gene to outside databases

Previous GC identifers: GC10P064237 GC10P064563 GC10P058884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NRBF2 Gene:
NRBF2 (nuclear receptor binding factor 2) is a protein-coding gene.

UniProtKB/Swiss-Prot: NRBF2_HUMAN, Q96F24
Function: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional
activator (in vitro)

Gene Wiki entry for NRBF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRBF2 gene promoter:
         AhR   USF1   NF-1   CUTL1   Nkx2-5   AP-4   Arnt   MEF-2A   USF-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRBF2 promoter sequence
   Search Chromatin IP Primers for NRBF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRBF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.1

NRBF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRBF2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P064893:  view genomic region     (about GC identifiers)

Start:
64,893,007 bp from pter      End:
64,914,786 bp from pter
Size:
21,780 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NRBF2_HUMAN, Q96F24 (See protein sequence)
Recommended Name: Nuclear receptor-binding factor 2  
Size: 287 amino acids; 32378 Da
Subunit: Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound
ligand. Interacts with SCOC
Sequence caution: Sequence=AAG44735.1; Type=Frameshift; Positions=234, 251, 278;
Secondary accessions: A6PW36 Q86UR2 Q96NP6 Q9H0S9 Q9H2I2
Alternative splicing: 2 isoforms:  Q96F24-1   Q96F24-2   

Explore the universe of human proteins at neXtProt for NRBF2: NX_Q96F24

Explore proteomics data for NRBF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NRBF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269334.1  NP_110386.2  

    ENSEMBL proteins: 
     ENSP00000277746   ENSP00000397502  
    Reactome Protein details: Q96F24

    NRBF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NRBF2
    OriGene Protein Over-expression Lysate for NRBF2
    OriGene MassSpec for NRBF2
    OriGene Custom Protein Services for NRBF2
    GenScript Custom Purified and Recombinant Proteins Services for NRBF2
    Novus Biologicals NRBF2 Proteins
    Novus Biologicals NRBF2 Lysates
    Sino Biological Recombinant Protein for NRBF2
    Sino Biological Cell Lysate for NRBF2
    ProSpec Recombinant Protein for NRBF2
    Cloud-Clone Corp. Proteins for NRBF2

     
    Search eBioscience for Proteins for NRBF2 

    NRBF2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NRBF2 
    OriGene Antibodies for NRBF2
    OriGene Custom Antibody Services for NRBF2
    Novus Biologicals NRBF2 Antibodies
    Abcam antibodies for NRBF2
    Cloud-Clone Corp. Antibodies for NRBF2
    ThermoFisher Antibodies for NRBF2
    LSBio Antibodies in human, mouse, rat for NRBF2

    NRBF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NRBF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NRBF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NRBF2
    Cloud-Clone Corp. CLIAs for NRBF2
    Search eBioscience for ELISAs for NRBF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR015056 DUF1875

    Graphical View of Domain Structure for InterPro Entry Q96F24

    ProtoNet protein and cluster: Q96F24


    Find genes that share domains with NRBF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRBF2_HUMAN, Q96F24
    Function: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional
    activator (in vitro)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRBF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NRBF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NRBF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NRBF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NRBF2:
    hsa-mir-98-5p (MIRT027700), hsa-mir-331-3p (MIRT043423)

    Block miRNA regulation of human, mouse, rat NRBF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRBF2 (see all 33):
    hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-128 hsa-miR-30d hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidNRBF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NRBF2
    Predesigned siRNA for gene silencing in human, mouse, rat NRBF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NRBF2

    Clone
    Products:
         
    OriGene clones in human, mouse for NRBF2 (see all 7)
    OriGene ORF clones in mouse, rat for NRBF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NRBF2 (NM_030759)
    Sino Biological Human cDNA Clone for NRBF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRBF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRBF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NRBF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for NRBF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRBF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NRBF2_HUMAN, Q96F24: Nucleus (By similarity). Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with NRBF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NRBF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    2Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67


    Find genes that share SuperPaths with NRBF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NRBF2
        Nuclear Receptor transcription pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRBF2
    Interactions:

        Search GeneGlobe Interaction Network for NRBF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for NRBF2 (Q96F243 ENSP000002777464) via UniProtKB, MINT, STRING, and/or I2D (see all 360)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with NRBF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRBF2

    4 Novoseek inferred chemical compound relationships for NRBF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 60.7 7 9268386 (1), 9326613 (1), 7759503 (1), 12538627 (1) (see all 7)
    phosphotyrosine 36.6 2 9254595 (1)
    phosphatidylinositol 36.3 1 9398740 (1)
    proline 20.3 1 8585605 (1)



    Find genes that share compounds with NRBF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NRBF2 gene (2 alternative transcripts): 
    NM_001282405.1  NM_030759.4  

    Unigene Cluster for NRBF2:

    Nuclear receptor binding factor 2
    Hs.449628  [show with all ESTs]
    Unigene Representative Sequence: NM_030759
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000277746(uc001jmj.4 uc010qip.2) ENST00000435510
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NRBF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NRBF2 (see all 33):
    hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-128 hsa-miR-30d hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidNRBF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NRBF2
    Predesigned siRNA for gene silencing in human, mouse, rat NRBF2
    Clone
    Products:
         
    OriGene clones in human, mouse for NRBF2 (see all 7)
    OriGene ORF clones in mouse, rat for NRBF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NRBF2 (NM_030759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NRBF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRBF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NRBF2
    OriGene qSTAR qPCR primer pairs in human, mouse for NRBF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRBF2
      QuantiTect SYBR Green Assays in human, mouse, rat NRBF2
      QuantiFast Probe-based Assays in human, mouse, rat NRBF2

    Additional mRNA sequence: 

    AF267866.1 AK054957.1 AK225256.1 AK225257.1 AK301656.1 AL136656.1 AY267839.1 AY267840.1 
    BC001345.1 BC011707.1 

    10 DOTS entries:

    DT.454737  DT.92434306  DT.100787012  DT.99947102  DT.95368543  DT.100758158  DT.120639547  DT.121328142 
    DT.100787011  DT.121252424 

    Selected AceView cDNA sequences (see all 174):

    Z38777 AA779349 BM465124 AA764862 BG390600 BX441595 BQ000526 BG259813 
    BI752263 AA825679 AI468725 AY267839 F07167 CR615835 CR603566 AW995786 
    F05492 CR607933 AA931195 BP335338 BI819246 BC011707 CR613482 Z42598 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NRBF2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                    -                                 
    SP2:                    -           -                     
    SP3:                                                      


    ECgene alternative splicing isoforms for NRBF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NRBF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NRBF2 Expression
    About this image


    NRBF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    NRBF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRBF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449628

    UniProtKB/Swiss-Prot: NRBF2_HUMAN, Q96F24
    Tissue specificity: Detected in keratinocytes, liver and placenta

        Custom PCR Arrays for NRBF2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NRBF2
    OriGene qSTAR qPCR primer pairs in human, mouse for NRBF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRBF2
    QuantiTect SYBR Green Assays in human, mouse, rat NRBF2
    QuantiFast Probe-based Assays in human, mouse, rat NRBF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRBF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NRBF2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrbf21 , 5 nuclear receptor binding factor 21, 5 85.08(n)1
    88.81(a)1
      10 (34.89 cM)5
    6413401  NM_001036293.21  NP_001031370.11 
     672666895 
    chicken
    (Gallus gallus)
    Aves NRBF21 nuclear receptor binding factor 2 78.98(n)
    82.23(a)
      423656  NM_001199533.1  NP_001186462.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRBF26
    nuclear receptor binding factor 2
    71(a)
    1 ↔ 1
    GL343204.1(2516918-2535687)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nrbf21 nuclear receptor binding factor 2 66.78(n)
    63.99(a)
      548937  NM_001016183.3  NP_001016183.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb26d032 Transcribed sequence with weak similarity to protein more 73.42(n)    CK027811.1 


    ENSEMBL Gene Tree for NRBF2 (if available)
    TreeFam Gene Tree for NRBF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NRBF2 gene

    Find genes that share paralogs with NRBF2           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for NRBF2
    PGOHUM00000238667 PGOHUM00000235041 PGOHUM00000244140 PGOHUM00000238018 PGOHUM00000249773


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NRBF2 (see all 450)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928803551,2
    --64891045(+) CCCTCC/TTTACT 1 -- us2k10--------
    rs1131504511,2
    C--64891294(+) CTCTGC/TCTTCC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1846398691,2
    --64891493(+) GTGAGA/CCAGTG 1 -- us2k10--------
    rs47469731,2
    C,F,H--64891633(+) TCCAAA/GGTTTC 1 -- us2k115Minor allele frequency- G:0.02NA WA CSA EA 512
    rs1899124881,2
    --64891730(+) AATTAA/GTCAAT 1 -- us2k10--------
    rs741387471,2
    C,F--64891829(+) TTAAAG/CCAGAT 1 -- us2k13Minor allele frequency- C:0.15WA CSA 122
    rs1170111781,2
    C,F--64892015(+) GAGTTG/AAGGCA 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs47469741,2
    C,A,H--64892052(+) TCTTTG/TTTTAA 1 -- us2k14Minor allele frequency- T:0.24NA EA 244
    rs583507771,2
    C,F--64892089(+) GATTAC/TGCCCT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs347562671,2
    C--64892165(+) GAGCT-/CCATTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NRBF2 (64893007 - 64914786 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NRBF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677353CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NRBF2
    DNA2.0 Custom Variant and Variant Library Synthesis for NRBF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with NRBF2           About GenesLikeMe

    2 Novoseek inferred disease relationships for NRBF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 0 1 17699761 (1)
    tumors 0 1 15958587 (1)


    Export disorders for NRBF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NRBF2 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with NRBF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and functional analysis of a keratinocyte-derived, ligand- regulated nuclear receptor comodulator. (PubMed id 15610520)1, 2 Flores A.M.... Aneskievich B.J. (J. Invest. Dermatol. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. (PubMed id 10786636)1, 3 Yasumo H....Osumi T. (Biochim. Biophys. Acta 2000)
    6. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PubMed id 24026423)1 Shameer K....Kullo I.J. (Hum. Genet. 2014)
    7. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)2 McKnight N.C.... Tooze S.A. (EMBO J. 2012)
    8. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. (PubMed id 20368287)1 Pilot-Storck F....Goillot E. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29982 HGNC: 19692 AceView: NRBF2 Ensembl:ENSG00000148572 euGenes: HUgn29982
    ECgene: NRBF2 H-InvDB: NRBF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NRBF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NRBF2 gene:
    Search GeneIP for patents involving NRBF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NRBF2   OriGene RNAi products in human, mouse, rat for NRBF2  
     OriGene qPCR primer pairs and template standards for NRBF2   OriGene Protein Over-expression Lysate for NRBF2  
     OriGene MassSpec something-or-other for NRBF2   OriGene clones in human, mouse for NRBF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NRBF2   OriGene Purified Protein for NRBF2  
     OriGene ORF clones in mouse, rat for NRBF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NRBF2   OriGene Custom Protein Services for NRBF2  

     
     
     Block miRNA regulation of human, mouse, rat NRBF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NRBF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRBF2 Predesigned siRNA for gene silencing in human, mouse, rat NRBF2
     QuantiFast Probe-based Assays in human, mouse, rat NRBF2 QuantiTect SYBR Green Assays in human, mouse, rat NRBF2
     Custom PCR Arrays for NRBF2 Search Chromatin IP Primers for NRBF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRBF2  Search GeneGlobe Interaction Network for NRBF2
     Regulatory tfbs in NRBF2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NRBF2 GenScript cDNA clones with any tag delivered in your preferred vector for NRBF2
     GenScript Custom Assay Services for NRBF2 GenScript Custom overexpressing Cell Line Services for NRBF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for NRBF2 

     Search Tocris compounds for NRBF2
     Proteins for NRBF2
     Cell Lysates for NRBF2
     cDNA Clones for NRBF2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NRBF2 antibodies
     NRBF2 proteins
     NRBF2 lysates
     Antibodies for NRBF2
     See all of Abcam's Antibodies, Kits and Proteins for NRBF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NRBF2
     Proteins for NRBF2
     Antibodies for NRBF2
     ELISAs for NRBF2
     CLIAs for NRBF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for NRBF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRBF2
     SwitchGear 3'UTR luciferase reporter plasmids for NRBF2
     SwitchGear Promoter luciferase reporter plasmids for NRBF2
     ThermoFisher Antibodies for NRBF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NRBF2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRBF2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NRBF2
     LSBio Antibodies in human, mouse, rat for NRBF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NRBF2
      Search eBioscience for proteins for NRBF2
      Search eBioscience for elisas for NRBF2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NRBF2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4