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Aliases for NRBF2 Gene

Aliases for NRBF2 Gene

  • Nuclear Receptor Binding Factor 2 2 3
  • Comodulator Of PPAR And RXR 1 2 3
  • Comodulator Of PPAR And RXR 2 2 3
  • NRBF-2 3 4
  • Nuclear Receptor Binding Factor-2 3
  • Nuclear Receptor-Binding Factor 2 3
  • Comodulator Of PPAR And RXR 4
  • COPR1 3
  • COPR2 3
  • COPR 4

External Ids for NRBF2 Gene

Previous GeneCards Identifiers for NRBF2 Gene

  • GC10P064237
  • GC10P064563
  • GC10P064893
  • GC10P058884

Summaries for NRBF2 Gene

GeneCards Summary for NRBF2 Gene

NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for NRBF2 Gene

  • May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).

Gene Wiki entry for NRBF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBF2 Gene

Genomics for NRBF2 Gene

Regulatory Elements for NRBF2 Gene

Genomic Location for NRBF2 Gene

Start:
63,133,247 bp from pter
End:
63,155,031 bp from pter
Size:
21,785 bases
Orientation:
Plus strand

Genomic View for NRBF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRBF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBF2 Gene

Proteins for NRBF2 Gene

  • Protein details for NRBF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F24-NRBF2_HUMAN
    Recommended name:
    Nuclear receptor-binding factor 2
    Protein Accession:
    Q96F24
    Secondary Accessions:
    • A6PW36
    • B4DWS0
    • Q86UR2
    • Q96NP6
    • Q9H0S9
    • Q9H2I2

    Protein attributes for NRBF2 Gene

    Size:
    287 amino acids
    Molecular mass:
    32378 Da
    Quaternary structure:
    • Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand. Interacts with SCOC.
    SequenceCaution:
    • Sequence=AAG44735.1; Type=Frameshift; Positions=234, 251, 278; Evidence={ECO:0000305};

    Alternative splice isoforms for NRBF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRBF2 Gene

Proteomics data for NRBF2 Gene at MOPED

Post-translational modifications for NRBF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRBF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NRBF2 Gene

Domains for NRBF2 Gene

Protein Domains for NRBF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRBF2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRBF2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NRBF2 Gene

Function for NRBF2 Gene

Molecular function for NRBF2 Gene

UniProtKB/Swiss-Prot Function: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).

Gene Ontology (GO) - Molecular Function for NRBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NRBF2: view

miRNA for NRBF2 Gene

miRTarBase miRNAs that target NRBF2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NRBF2 Gene

Localization for NRBF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBF2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRBF2 Gene COMPARTMENTS Subcellular localization image for NRBF2 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NRBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NRBF2: view

Pathways for NRBF2 Gene

genes like me logo Genes that share pathways with NRBF2: view

Pathways by source for NRBF2 Gene

Gene Ontology (GO) - Biological Process for NRBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NRBF2: view

Compounds for NRBF2 Gene

(4) Novoseek inferred chemical compound relationships for NRBF2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 60.7 7
phosphotyrosine 36.6 1
phosphatidylinositol 36.3 1
proline 20.3 1
genes like me logo Genes that share compounds with NRBF2: view

Transcripts for NRBF2 Gene

Unigene Clusters for NRBF2 Gene

Nuclear receptor binding factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRBF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for NRBF2 Gene

GeneLoc Exon Structure for
NRBF2
ECgene alternative splicing isoforms for
NRBF2

Expression for NRBF2 Gene

mRNA expression in normal human tissues for NRBF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRBF2 Gene

This gene is overexpressed in Whole Blood (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRBF2 Gene

SOURCE GeneReport for Unigene cluster for NRBF2 Gene Hs.449628

mRNA Expression by UniProt/SwissProt for NRBF2 Gene

Q96F24-NRBF2_HUMAN
Tissue specificity: Detected in keratinocytes, liver and placenta.
genes like me logo Genes that share expressions with NRBF2: view

Orthologs for NRBF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRBF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRBF2 35
  • 99.77 (n)
  • 99.65 (a)
NRBF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRBF2 35
  • 92.45 (n)
  • 93.38 (a)
NRBF2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRBF2 35
  • 89.9 (n)
  • 92.33 (a)
NRBF2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrbf2 35
  • 85.08 (n)
  • 88.81 (a)
Nrbf2 16
Nrbf2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRBF2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRBF2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrbf2 35
  • 84.85 (n)
  • 91.26 (a)
chicken
(Gallus gallus)
Aves NRBF2 35
  • 78.98 (n)
  • 82.23 (a)
NRBF2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRBF2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrbf2 35
  • 66.78 (n)
  • 63.99 (a)
zebrafish
(Danio rerio)
Actinopterygii NRBF2 (2 of 2) 36
  • 52 (a)
OneToMany
nrbf2b 35
  • 60.9 (n)
  • 62.03 (a)
nrbf2b 36
  • 59 (a)
OneToMany
wufb26d03 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for NRBF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRBF2 Gene

ENSEMBL:
Gene Tree for NRBF2 (if available)
TreeFam:
Gene Tree for NRBF2 (if available)

Paralogs for NRBF2 Gene

genes like me logo Genes that share paralogs with NRBF2: view

No data available for Paralogs for NRBF2 Gene

Variants for NRBF2 Gene

Sequence variations from dbSNP and Humsavar for NRBF2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2539 -- 63,154,767(-) GAGGT(C/T)ATCAT utr-variant-3-prime
rs13095 -- 63,154,612(-) CCGGC(C/G)ACCAT utr-variant-3-prime
rs868798 -- 63,135,250(-) CTGTA(C/T)TTCAT intron-variant
rs871689 -- 63,134,287(+) TTCTT(G/T)TCAGA intron-variant
rs871690 -- 63,134,299(+) TGGCC(A/G)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRBF2 Gene

Variant ID Type Subtype PubMed ID
esv2677353 CNV Deletion 23128226

Relevant External Links for NRBF2 Gene

HapMap Linkage Disequilibrium report
NRBF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRBF2 Gene

Disorders for NRBF2 Gene

(2) Novoseek inferred disease relationships for NRBF2 Gene

Disease -log(P) Hits PubMed IDs
metastasis 0 1
tumors 0 1
genes like me logo Genes that share disorders with NRBF2: view

No data available for UniProtKB/Swiss-Prot for NRBF2 Gene

Publications for NRBF2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Isolation and functional analysis of a keratinocyte-derived, ligand- regulated nuclear receptor comodulator. (PMID: 15610520) Flores A.M. … Aneskievich B.J. (J. Invest. Dermatol. 2004) 3 4
  4. Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. (PMID: 10786636) Yasumo H. … Osumi T. (Biochim. Biophys. Acta 2000) 2 3
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for NRBF2 Gene

Sources for NRBF2 Gene

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