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Aliases for NRBF2 Gene

Aliases for NRBF2 Gene

  • Nuclear Receptor Binding Factor 2 2 3 5
  • Comodulator Of PPAR And RXR 1 2 3
  • Comodulator Of PPAR And RXR 2 2 3
  • NRBF-2 3 4
  • COPR 3 4
  • Nuclear Receptor Binding Factor-2 3
  • Comodulator Of PPAR And RXR 4
  • COPR1 3
  • COPR2 3

External Ids for NRBF2 Gene

Previous GeneCards Identifiers for NRBF2 Gene

  • GC10P064237
  • GC10P064563
  • GC10P064893
  • GC10P058884

Summaries for NRBF2 Gene

GeneCards Summary for NRBF2 Gene

NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway.

UniProtKB/Swiss-Prot for NRBF2 Gene

  • May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).

  • Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).

Gene Wiki entry for NRBF2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRBF2 Gene

Genomics for NRBF2 Gene

Regulatory Elements for NRBF2 Gene

Enhancers for NRBF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NRBF2 on UCSC Golden Path with GeneCards custom track

Promoters for NRBF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRBF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NRBF2 Gene

Chromosome:
10
Start:
63,133,247 bp from pter
End:
63,155,031 bp from pter
Size:
21,785 bases
Orientation:
Plus strand

Genomic View for NRBF2 Gene

Genes around NRBF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRBF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRBF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRBF2 Gene

Proteins for NRBF2 Gene

  • Protein details for NRBF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F24-NRBF2_HUMAN
    Recommended name:
    Nuclear receptor-binding factor 2
    Protein Accession:
    Q96F24
    Secondary Accessions:
    • A6PW36
    • B4DWS0
    • Q86UR2
    • Q96NP6
    • Q9H0S9
    • Q9H2I2

    Protein attributes for NRBF2 Gene

    Size:
    287 amino acids
    Molecular mass:
    32378 Da
    Quaternary structure:
    • Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand (PubMed:15610520). Interacts with SCOC (PubMed:22354037). Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (PubMed:24785657).
    SequenceCaution:
    • Sequence=AAG44735.1; Type=Frameshift; Positions=234, 251, 278; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NRBF2 Gene

    Alternative splice isoforms for NRBF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRBF2 Gene

Proteomics data for NRBF2 Gene at MOPED

Post-translational modifications for NRBF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRBF2 Gene

No data available for DME Specific Peptides for NRBF2 Gene

Domains & Families for NRBF2 Gene

Protein Domains for NRBF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NRBF2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NRBF2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NRBF2 Gene

Function for NRBF2 Gene

Molecular function for NRBF2 Gene

UniProtKB/Swiss-Prot Function:
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
UniProtKB/Swiss-Prot Function:
Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).

Phenotypes for NRBF2 Gene

genes like me logo Genes that share phenotypes with NRBF2: view

Animal Model Products

miRNA for NRBF2 Gene

miRTarBase miRNAs that target NRBF2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NRBF2 Gene

Localization for NRBF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRBF2 Gene

Nucleus. Cytoplasm. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRBF2 Gene COMPARTMENTS Subcellular localization image for NRBF2 gene
Compartment Confidence
nucleus 5
vacuole 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NRBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NRBF2: view

Pathways & Interactions for NRBF2 Gene

genes like me logo Genes that share pathways with NRBF2: view

Pathways by source for NRBF2 Gene

Gene Ontology (GO) - Biological Process for NRBF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010506 regulation of autophagy IMP 24785657
genes like me logo Genes that share ontologies with NRBF2: view

No data available for SIGNOR curated interactions for NRBF2 Gene

Drugs & Compounds for NRBF2 Gene

(2) Drugs for NRBF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for NRBF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NRBF2: view

Transcripts for NRBF2 Gene

Unigene Clusters for NRBF2 Gene

Nuclear receptor binding factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRBF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for NRBF2 Gene

GeneLoc Exon Structure for
NRBF2
ECgene alternative splicing isoforms for
NRBF2

Expression for NRBF2 Gene

mRNA expression in normal human tissues for NRBF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRBF2 Gene

This gene is overexpressed in Whole Blood (x7.7).

Protein differential expression in normal tissues from HIPED for NRBF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.2), Placenta (12.2), and Spleen (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRBF2 Gene



SOURCE GeneReport for Unigene cluster for NRBF2 Gene Hs.449628

mRNA Expression by UniProt/SwissProt for NRBF2 Gene

Q96F24-NRBF2_HUMAN
Tissue specificity: Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852).
genes like me logo Genes that share expression patterns with NRBF2: view

Protein tissue co-expression partners for NRBF2 Gene

Primer Products

Orthologs for NRBF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRBF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRBF2 35
  • 92.45 (n)
  • 93.38 (a)
NRBF2 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRBF2 35
  • 89.9 (n)
  • 92.33 (a)
NRBF2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrbf2 35
  • 85.08 (n)
  • 88.81 (a)
Nrbf2 16
Nrbf2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRBF2 35
  • 99.77 (n)
  • 99.65 (a)
NRBF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrbf2 35
  • 84.85 (n)
  • 91.26 (a)
oppossum
(Monodelphis domestica)
Mammalia NRBF2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRBF2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRBF2 35
  • 78.98 (n)
  • 82.23 (a)
NRBF2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRBF2 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrbf2 35
  • 66.78 (n)
  • 63.99 (a)
zebrafish
(Danio rerio)
Actinopterygii nrbf2b 35
  • 60.9 (n)
  • 62.03 (a)
wufb26d03 35
NRBF2 (2 of 2) 36
  • 52 (a)
OneToMany
nrbf2b 36
  • 59 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for NRBF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRBF2 Gene

ENSEMBL:
Gene Tree for NRBF2 (if available)
TreeFam:
Gene Tree for NRBF2 (if available)

Paralogs for NRBF2 Gene

genes like me logo Genes that share paralogs with NRBF2: view

No data available for Paralogs for NRBF2 Gene

Variants for NRBF2 Gene

Sequence variations from dbSNP and Humsavar for NRBF2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1533068 -- 63,132,407(+) AGCTC(A/C)CTTGA upstream-variant-2KB
rs1533069 -- 63,132,408(+) GCTCA(A/C)TTGAG upstream-variant-2KB
rs2539 -- 63,154,767(-) GAGGT(C/T)ATCAT utr-variant-3-prime
rs13095 -- 63,154,612(-) CCGGC(C/G)ACCAT utr-variant-3-prime
rs2016673 -- 63,135,033(-) ttttt(C/G)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRBF2 Gene

Variant ID Type Subtype PubMed ID
esv2677353 CNV Deletion 23128226

Variation tolerance for NRBF2 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NRBF2 Gene

Disorders for NRBF2 Gene

Relevant External Links for NRBF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRBF2

No disorders were found for NRBF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRBF2 Gene

Publications for NRBF2 Gene

  1. Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. (PMID: 25086043) Zhong Y. … Wang Q.J. (J. Biol. Chem. 2014) 3 4 67
  2. Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. (PMID: 10786636) Yasumo H. … Osumi T. (Biochim. Biophys. Acta 2000) 2 3
  3. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression. (PMID: 26073781) Darabi H. … Chenevix-Trench G. (Am. J. Hum. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for NRBF2 Gene

Sources for NRBF2 Gene

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