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Aliases for NRAS Gene

Aliases for NRAS Gene

  • Neuroblastoma RAS Viral Oncogene Homolog 2 3 5
  • Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog 2 3
  • Transforming Protein N-Ras 3 4
  • V-Ras Neuroblastoma RAS Viral Oncogene Homolog 3
  • N-Ras Protein Part 4 3
  • GTPase NRas 3
  • HRAS1 4
  • ALPS4 3
  • N-Ras 3
  • NRAS1 3
  • CMNS 3
  • NCMS 3
  • NS6 3

External Ids for NRAS Gene

Previous GeneCards Identifiers for NRAS Gene

  • GC01M115662
  • GC01M114131
  • GC01M114349
  • GC01M114548
  • GC01M114961
  • GC01M115048
  • GC01M115247
  • GC01M113105

Summaries for NRAS Gene

Entrez Gene Summary for NRAS Gene

  • This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]

GeneCards Summary for NRAS Gene

NRAS (Neuroblastoma RAS Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with NRAS include Ras-Associated Autoimmune Leukoproliferative Disorder and Melanocytic Nevus Syndrome, Congenital, Somatic. Among its related pathways are RET signaling and VEGF Signaling Pathway. GO annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for NRAS Gene

  • Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Gene Wiki entry for NRAS Gene

PharmGKB "VIP" Summary for NRAS Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for NRAS Gene

Genomics for NRAS Gene

Regulatory Elements for NRAS Gene

Enhancers for NRAS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F114712 0.4 ENCODE 0.8 +3.6 3621 1.0 ZNF121 POLR2A DENND2C CSDE1 NRAS RN7SL432P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRAS on UCSC Golden Path with GeneCards custom track

Promoters for NRAS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NRAS Gene

114,704,464 bp from pter
114,716,894 bp from pter
12,431 bases
Minus strand

Genomic View for NRAS Gene

Genes around NRAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRAS Gene

Proteins for NRAS Gene

  • Protein details for NRAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTPase NRas
    Protein Accession:
    Secondary Accessions:
    • Q14971
    • Q15104
    • Q15282

    Protein attributes for NRAS Gene

    189 amino acids
    Molecular mass:
    21229 Da
    Quaternary structure:
    • Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7.
    • Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumors.

    Three dimensional structures from OCA and Proteopedia for NRAS Gene

neXtProt entry for NRAS Gene

Post-translational modifications for NRAS Gene

  • Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).
  • Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
  • Ubiquitination at Lys 128
  • Modification sites at PhosphoSitePlus

Other Protein References for NRAS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NRAS Gene

Domains & Families for NRAS Gene

Gene Families for NRAS Gene

Suggested Antigen Peptide Sequences for NRAS Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with NRAS: view

Function for NRAS Gene

Molecular function for NRAS Gene

GENATLAS Biochemistry:
neuroblastoma Ras viral (v-ras) oncogene homolog
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
UniProtKB/Swiss-Prot Function:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Gene Ontology (GO) - Molecular Function for NRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005525 GTP binding IEA --
GO:0032403 protein complex binding IDA 23209302
genes like me logo Genes that share ontologies with NRAS: view
genes like me logo Genes that share phenotypes with NRAS: view

Human Phenotype Ontology for NRAS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NRAS Gene

MGI Knock Outs for NRAS:

Animal Model Products

miRNA for NRAS Gene

miRTarBase miRNAs that target NRAS

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NRAS Gene

Localization for NRAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRAS Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRAS gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
cytosol 4
nucleus 3
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005794 Golgi apparatus IEA,IDA 21968647
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with NRAS: view

Pathways & Interactions for NRAS Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 IL-2 Pathway
4 Glioma
5 fMLP Pathway
genes like me logo Genes that share pathways with NRAS: view

Pathways by source for NRAS Gene

SIGNOR curated interactions for NRAS Gene

Gene Ontology (GO) - Biological Process for NRAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0007165 signal transduction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with NRAS: view

Drugs & Compounds for NRAS Gene

(20) Drugs for NRAS Gene - From: PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1980
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2690
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1974
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 737
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1918

(2) Additional Compounds for NRAS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for NRAS Gene

Compound Action Cas Number
Kobe0065 Ras inhibitor 436133-68-5
kobe2602 Ras inhibitor 454453-49-7
Salirasib Inhibitor of active Ras protein 162520-00-5
genes like me logo Genes that share compounds with NRAS: view

Transcripts for NRAS Gene

mRNA/cDNA for NRAS Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1776) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NRAS Gene

Neuroblastoma RAS viral (v-ras) oncogene homolog:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRAS Gene

No ASD Table

Relevant External Links for NRAS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NRAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NRAS Gene

This gene is overexpressed in Brain (10.2), Peripheral blood mononuclear cells (9.0), and Bone (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NRAS Gene

Protein tissue co-expression partners for NRAS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NRAS Gene:


SOURCE GeneReport for Unigene cluster for NRAS Gene:

genes like me logo Genes that share expression patterns with NRAS: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NRAS Gene

Orthologs for NRAS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NRAS Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia N-RAS 35
  • 100 (a)
  • 95.77 (n)
(Pan troglodytes)
Mammalia NRAS 34 35
  • 99.82 (n)
(Monodelphis domestica)
Mammalia NRAS 35
  • 98 (a)
-- 35
  • 84 (a)
(Bos Taurus)
Mammalia NRAS 34 35
  • 95.24 (n)
(Mus musculus)
Mammalia Nras 34 16 35
  • 91.71 (n)
(Rattus norvegicus)
Mammalia Nras 34
  • 90.83 (n)
(Ornithorhynchus anatinus)
Mammalia NRAS 35
  • 75 (a)
(Gallus gallus)
Aves N-RAS 35
  • 97 (a)
  • 81.13 (n)
(Anolis carolinensis)
Reptilia NRAS 35
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC549517 34
  • 78.48 (n)
Str.17112 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.895 34
(Danio rerio)
Actinopterygii nras 34 35
  • 78.72 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Ras85D 36 35
  • 85 (a)
(Caenorhabditis elegans)
Secernentea let-60 35
  • 76 (a)
C08F8.7 36
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAS1 35
  • 36 (a)
RAS2 35
  • 35 (a)
Species where no ortholog for NRAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRAS Gene

Gene Tree for NRAS (if available)
Gene Tree for NRAS (if available)

Paralogs for NRAS Gene

Paralogs for NRAS Gene

genes like me logo Genes that share paralogs with NRAS: view

Variants for NRAS Gene

Sequence variations from dbSNP and Humsavar for NRAS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11554290 Keratinocytic non-epidermolytic nevus (KNEN) [MIM:162900], Melanocytic nevus syndrome, congenital (CMNS) [MIM:137550], Melanosis, neurocutaneous (NCMS) [MIM:249400], Thyroid cancer, non-medullary, 2 (NMTC2) [MIM:188470], Pathogenic 114,713,908(-) TGGAC(A/C/G/T)AGAAG reference, missense
rs121434595 Melanocytic nevus syndrome, congenital (CMNS) [MIM:137550], Pathogenic 114,716,124(-) CAGGT(A/C/G/T)GTGTT reference, missense
rs121434596 Leukemia, juvenile myelomonocytic (JMML) [MIM:607785], RAS-associated autoimmune leukoproliferative disorder (RALD) [MIM:614470], Pathogenic 114,716,123(-) AGGTG(A/C/G/T)TGTTG reference, missense
rs121913237 Leukemia, juvenile myelomonocytic (JMML) [MIM:607785], Keratinocytic non-epidermolytic nevus (KNEN) [MIM:162900], Pathogenic 114,716,126(-) AGCAG(A/C/G/T)TGGTG reference, missense
rs121913250 Leukemia, Pathogenic 114,716,127(-) GAGCA(A/C/G/T)GTGGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NRAS Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV loss 19812545
nsv946157 CNV duplication 23825009

Variation tolerance for NRAS Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRAS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRAS Gene

Disorders for NRAS Gene

MalaCards: The human disease database

(60) MalaCards diseases for NRAS Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ras-associated autoimmune leukoproliferative disorder
  • autoimmune lymphoproliferative syndrome type iv
melanocytic nevus syndrome, congenital, somatic
  • spitz nevus or nevus spilus, somatic
thyroid cancer, nonmedullary, 2
  • thyroid carcinoma, follicular, somatic
noonan syndrome 6
  • nras gene related noonan syndrome
neurocutaneous melanosis, somatic
  • melanosis, neurocutaneous
- elite association - COSMIC cancer census association via MalaCards
Search NRAS in MalaCards View complete list of genes associated with diseases


  • Keratinocytic non-epidermolytic nevus (KNEN) [MIM:162900]: Epidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood. {ECO:0000269 PubMed:22499344}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. {ECO:0000269 PubMed:17332249}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Melanocytic nevus syndrome, congenital (CMNS) [MIM:137550]: A syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip. {ECO:0000269 PubMed:18633438, ECO:0000269 PubMed:23392294}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Melanosis, neurocutaneous (NCMS) [MIM:249400]: A rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma. {ECO:0000269 PubMed:23392294}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. {ECO:0000269 PubMed:19966803}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • RAS-associated autoimmune leukoproliferative disorder (RALD) [MIM:614470]: A disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies. {ECO:0000269 PubMed:17517660}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Thyroid cancer, non-medullary, 2 (NMTC2) [MIM:188470]: A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. {ECO:0000269 PubMed:12727991}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for NRAS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NRAS: view

No data available for Genatlas for NRAS Gene

Publications for NRAS Gene

  1. Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma. (PMID: 20140953) Conway C. … Newton-Bishop J.A. (Genes Chromosomes Cancer 2010) 3 22 46 64
  2. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. (PMID: 19047918) Yoshida N. … Kojima S. (Pediatr. Res. 2009) 3 22 46 64
  3. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. (PMID: 18450602) Schlenk R.F. … DAPhner H. (N. Engl. J. Med. 2008) 3 22 46 64
  4. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. (PMID: 18615679) Agaram N.P. … Antonescu C.R. (Genes Chromosomes Cancer 2008) 3 22 46 64
  5. Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. (PMID: 17507627) Thomas N.E. … Conway K. (Cancer Epidemiol. Biomarkers Prev. 2007) 3 22 46 64

Products for NRAS Gene

Sources for NRAS Gene

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