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NRAS Gene

protein-coding GIFtS: 65

GC01M115048

neuroblastoma RAS viral (v-ras) oncogene homolog
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALPS4 ^², ⁵
HRAS1 ^³
N-ras ^²
NRAS1 ^²
OTTHUMP00000013879 ^²

Descriptions
N-ras protein part 4 ^²
Transforming protein N-Ras ^³
neuroblastoma RAS viral (v-ras) oncogene homolog ^²
v-ras neuroblastoma RAS viral oncogene homolog ^²

External Ids
HGNC: 7989¹
Entrez Gene: 4893²
UniProtKB: P01111³
Ensembl: ENSG00000213281⁷

Search outside databases for aliases for NRAS gene

Previous GC identifers: GC01M115662 GC01M114131 GC01M114349 GC01M114548 GC01M114961

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NRAS:

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and

the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by

the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated

to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a

guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic

leukemia (JMML). [provided by RefSeq]

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111

Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Gene Wiki entry for NRAS (Neuroblastoma_RAS_viral_oncogene_homolog)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NRAS gene

Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.2

NRAS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M115048: (about GC identifiers)

Start:	115,051,108 bp from pter
End:	115,061,038 bp from pter
Size:	9,931 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111 (See protein sequence)

Recommended Name: GTPase NRas precursor

Size: 189 amino acids; 21229 Da

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane;

Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus

PDB structures from and Proteopedia :

3CON (3D)

Secondary accessions: Q14971 Q15104 Q15282

Post-translational modifications:

Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation

regulates rapid exchange between plasma membrane and Golgi¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002515.1

ENSEMBL proteins:

ENSP00000358548 ENSP00000385392

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (N ras + c Ha ras, Ras, NRAS)
	Human Recombinant Proteins from Abnova (NRAS)

OriGene Purified Recombinant Human Protein: NRAS

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005622	intracellular	IEA	--
GO:0005624	membrane fraction	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for NRAS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NRAS
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for NRAS (N-ras)
	Antibodies from Abcam (N ras + c Ha ras, Ras, NRAS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NRAS)
	Novus Biologicals Antibodies for NRAS

Assays for NRAS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01111

ProtoNet protein and cluster: P01111

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NRAS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NRAS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002524

Applied Biosystems Silencer® siRNAs for NRAS

Sigma-Aldrich siRNA and siRNA Panels for NRAS

Sigma-Aldrich shRNA Panels for NRAS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NRAS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002524
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002524
untagged cDNA clone in CMV expression vector: NM_002524

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002524

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111

Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Enzyme regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP.

Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating

protein (GAP)

Genatlas biochemistry entry for NRAS:

neuroblastoma Ras viral (v-ras) oncogene homolog

14 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nras):

	cellular	digestive/alimentary	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	limbs/digits/tail
liver/biliary system	normal	skin/coat/nails	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/88 Sigma-Aldrich "Your Favorite Gene" Pathways for NRAS (Your Favorite Gene powered by Ingenuity) (see all 88 )

HIF1&alpha
PI3K/AKT Signaling
Melanoma Signaling
ERK/MAPK Signaling
Thrombin Signaling

GeneDecks NRAS for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NRAS

1 Interacting protein for NRAS (P01111²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
PLCE1 Q9P212² MINT-65550
About this table
5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007265 Ras protein signal transduction EXP 11520933
GO:0007569 cell aging IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008542 visual learning IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NRAS
2 Novoseek chemical compound relationships for NRAS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	10.21	5	18450602 (2), 16467864 (1), 16281072 (1)
oligonucleotide	0.00	1	8255093 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NRAS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NRAS)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002524

Sigma-Aldrich siRNA and siRNA Panels for NRAS

Sigma-Aldrich shRNA Panels for NRAS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002524

REFSEQ mRNAs for NRAS gene:

NM_002524.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002524

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002524
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002524
                                 untagged cDNA clone in CMV expression vector: NM_002524

Additional cDNA sequence:

AF493919.1 AY941100.1 AY941101.1 BC005219.1 BC013214.1 BT019734.1 BT019735.1 CR595772.1

CR596134.1 CR598435.1 CR605091.1 CR615916.1 X02751.1

16 DOTS entries:

DT.40115049 DT.100693486 DT.100811463 DT.92360379 DT.121460043 DT.100693463 DT.121460084 DT.100693473

DT.121459944 DT.121460006 DT.100041872 DT.100766644 DT.121460114 DT.91838834 DT.92474344 DT.92474389

24/1776 AceView cDNA sequences (see all 1776 ):

AA977969 AW024266 AA446246 BP383529 BF969612 AI905766 BE615767 AW515621

CF140474 AI636822 AI092959 BM667890 AW069440 CF121779 AI536782 BU156589

CR598435 BF725317 AW674304 BG257341 BQ941042 AI754026 AI207185 AA171411

highest scoring ESTs for NRAS:

BM473479 BX421385 AI245939 AW015544 BE093979 BE094084 BE884314 BF218537 BF815030 BM473613

Unigene Cluster for NRAS:

Neuroblastoma RAS viral (v-ras) oncogene homolog

Hs.486502 [show with all ESTs]

Unigene Representative Sequence: NM_002524

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000369535 ENST00000406761

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NRAS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NRAS

¹ / ² / ³

7 probe-sets matching NRAS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1539_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X02751	0.80	0.70	0.75	1
224985_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
202647_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002524	0.40	0.50	0.45	1
202646_s_at²	U133-A	2	0.91	0.46	--	--	--	--	--	--	--
224985_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202647_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202646_s_at²	U133Plus2	2	0.91	0.46	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.486502
Expression variation in blood from EXPOLDB for NRAS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NRAS gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NRAS¹	--	neuroblastoma RAS viral (v-ras) oncogene homolog	95.77(n) 100(a)	403872 XM_843536.1 XP_848629.1
chimpanzee (Pan troglodytes)	NRAS¹	--	neuroblastoma RAS viral (v-ras) oncogene homolog	99.82(n) 100(a)	742713 XM_001149822.1 XP_001149822.1
cow (Bos taurus)	NRAS¹	--	neuroblastoma RAS viral (v-ras) oncogene homolog	95.24(n) 100(a)	506322 XM_582752.3 XP_582752.2
rat (Rattus norvegicus)	Nras¹	--	neuroblastoma ras oncogene	90.83(n) 99.47(a)	24605 NM_080766.1 NP_542944.1
mouse (Mus musculus)	Nras^{1, 5}	3 (48.50 cM)⁵	neuroblastoma ras oncogene^{1, 5}	91.71(n)¹ 99.47(a)¹	18176¹ NM_010937.2¹ NP_035067.2¹ AK011704⁵ AK150357⁵ (see all 24)

About this table Species with no ortholog for NRAS

ENSEMBL Gene Tree for NRAS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NRAS gene

KRAS² HRAS² ERAS²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/96 NCBI SNPs in NRAS are shown (see all 96 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs14804^1,2	A,C,F,H	115051366(-)	`AAGCAC/TATGAA`	1	--	ut3¹		14	MN NS EU EA WA	1622
	rs9724644^1,2	F,H	115051551(-)	`ATTTCA/GGTGGA`	1	--	ut3¹		5	NS EU EA WA	580
	rs9724642^1,2	F,H	115051892(-)	`CAAACG/ATGAAA`	1	--	ut3¹		5	NS EU EA WA	570
--	rs11554290^1,2	H	115058052(-)	`TGGACA/GAGAAG`	1	Q/R	mis¹		4	EU EA WA	404
--	rs9724643^1,2	F	115051822(-)	`TTTTTA/CCTGTT`	1	--	ut3¹		1	NS	154
	rs969273^1,2	C,F,H,O	115058192(-)	`CATTGT/CATTCC`	1	--	int¹		12	MN EU EA WA NS	1250
	rs6671984^1,2	A,C,F,H	115059044(+)	`GGCTAT/CATTAG`	1	--	int¹		15	EU EA WA NS	1490
	rs9724630^1,2	C,F,H	115057240(-)	`CATAGA/GACCAT`	1	--	int¹		10	NS EA WA	886
	rs9724631^1,2	F,H	115057087(-)	`AAGCTC/TCTTTT`	1	--	int¹		5	NS EU EA WA	568
	rs9724632^1,2	F,H	115057027(-)	`actctG/Tcctgg`	1	--	int¹		5	NS EU EA WA	524

About this table

HapMap Linkage Disequilibrium images for NRAS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164790

UniProtKB/Swiss-Prot: RASN_HUMAN, P01111

Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML

is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of

myelodysplastic syndrome (MDS) and 2% of leukemia

Mutations which change AA 12, 13 or 61 activate the potential of Ras to transform cultured

cells and are implicated in a variety of human tumors

10/20 Novoseek disease relationships for NRAS gene (see all 20 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	75.58	94	15917418 (5), 18227705 (5), 18375819 (4), 16899595 (4) (see all 31)
preleukemia	74.50	1	7949098 (1)
myelodysplastic syndromes	65.68	4	15257941 (2), 15474158 (1), 9379676 (1)
leukemogenesis	61.93	1	9680114 (1)
somatic mutations	61.58	5	15188009 (1), 10216104 (1), 17507627 (1), 18000165 (1) (see all 5)
nevi	59.21	8	16845322 (2), 17518771 (1), 17507627 (1)
nevi melanocytic	50.67	2	16845322 (1), 15009714 (1)
metastatic melanoma	50.06	2	14695152 (1), 17518771 (1)
uveal melanoma	48.80	1	14522897 (1)
karyotype abnormal	41.57	1	9305595 (1)

About this table

Human Gene Mutation Database: NRAS
Genetic Association Database: NRAS
Human Genome Epidemiology Navigator: NRAS (22 documents)
Tumor Gene Database: NRAS
Breast Cancer Gene Database: NRAS

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/182 PubMed articles for NRAS gene (see all 182 ):

BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. (PubMed id 16098042)^{1, 3, 6} Akslen L.A....Kumar R. (2005)
DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. (PubMed id 16000296)^{3, 4} Swarthout J.T.... Linder M.E. (2005)
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. (PubMed id 15705808)^{3, 4} Rocks O....Bastiaens P.I.H. (2005)
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. (PubMed id 16076867)^{3, 6} Schnittger S....Falini B. (2005)
Ras gene mutations in patients with acute myeloid leukaemia and exposure to chemical agents. (PubMed id 14688017)^{3, 6} Barletta E....Costantini A.S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay. (PubMed id 1970154)^{3, 4} Yuasa Y.... Tonomura A. (1990)
All ras proteins are polyisoprenylated but only some are palmitoylated. (PubMed id 2661017)^{3, 4} Hancock J.F.... Marshall C.J. (1989)
Delection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay. (PubMed id 3276402)^{3, 4} Raybaud F.... Birnbaum D. (1988)
A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome. (PubMed id 3295562)^{3, 4} Hirai H.... Takaku F. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4893	HGNC: 7989	AceView: NRASandUNR	Ensembl:ENSG00000213281	euGenes: HUgn4893
ECgene: NRAS	H-InvDB: NRAS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NRAS	Genetics and Cytogenetics in Oncology and Haematology
NRASbase	http://bioinf.uta.fi/NRASbase/
NIEHS-SNPs	http://egp.gs.washington.edu/data/nras/
Wikipedia	http://en.wikipedia.org/wiki/RAS_proteins

Licensable Technologies for NRAS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NRAS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NRAS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NRAS		Antibodies for NRAS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NRAS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NRAS)
	Antibodies (NRAS)
	Chimera RNAi (NRAS)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for NRAS (N-ras)

	Recombinant Proteins (N ras + c Ha ras, Ras, NRAS)
	Antibodies (N ras + c Ha ras, Ras, NRAS)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for NRAS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NRAS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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NRAS Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for NRAS

Summaries
for NRAS

Genomic Location
for NRAS

Proteins
for NRAS

Protein Domains/
Families
for NRAS

Gene Function
for NRAS

Pathways & Interactions
for NRAS

Drugs & Compounds
for NRAS

Transcripts
for NRAS

Expression
for NRAS

Orthologs
for NRAS

Paralogs
for NRAS

SNPs/Variants
for NRAS

Disorders & Mutations
for NRAS

Medical News
for NRAS

Publications
for NRAS

Search for NRAS

Genome Databases showing NRAS

Other Databases showing NRAS

Specialized Databases showing NRAS

Licensable Technologies
for NRAS

Services
for NRAS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NRAS Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor NRAS

Summariesfor NRAS

Genomic Locationfor NRAS

Proteinsfor NRAS

Protein Domains/Familiesfor NRAS

Gene Functionfor NRAS

Pathways & Interactionsfor NRAS

Drugs & Compoundsfor NRAS

Transcriptsfor NRAS

Expression for NRAS

Orthologsfor NRAS

Paralogsfor NRAS

SNPs/Variantsfor NRAS

Disorders & Mutationsfor NRAS

Medical Newsfor NRAS

Publicationsfor NRAS

Search for NRAS

Genome Databases showing NRAS

Other Databases showing NRAS

Specialized Databases showing NRAS

Licensable Technologiesfor NRAS

Servicesfor NRAS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NRAS

Summaries
for NRAS

Genomic Location
for NRAS

Proteins
for NRAS

Protein Domains/
Families
for NRAS

Gene Function
for NRAS

Pathways & Interactions
for NRAS

Drugs & Compounds
for NRAS

Transcripts
for NRAS

Expression
for NRAS

Orthologs
for NRAS

Paralogs
for NRAS

SNPs/Variants
for NRAS

Disorders & Mutations
for NRAS

Medical News
for NRAS

Publications
for NRAS

Licensable Technologies
for NRAS

Services
for NRAS