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Aliases for NRARP Gene

Aliases for NRARP Gene

  • NOTCH-Regulated Ankyrin Repeat Protein 2 3 5

External Ids for NRARP Gene

Previous GeneCards Identifiers for NRARP Gene

  • GC09M139315
  • GC09M140194
  • GC09M109653

Summaries for NRARP Gene

GeneCards Summary for NRARP Gene

NRARP (NOTCH-Regulated Ankyrin Repeat Protein) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathways. An important paralog of this gene is PPP1R27.

UniProtKB/Swiss-Prot for NRARP Gene

  • Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRARP Gene

Genomics for NRARP Gene

Regulatory Elements for NRARP Gene

Promoters for NRARP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NRARP on UCSC Golden Path with GeneCards custom track

Genomic Location for NRARP Gene

Chromosome:
9
Start:
137,299,631 bp from pter
End:
137,302,251 bp from pter
Size:
2,621 bases
Orientation:
Minus strand

Genomic View for NRARP Gene

Genes around NRARP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRARP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRARP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRARP Gene

Proteins for NRARP Gene

  • Protein details for NRARP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6K4-NRARP_HUMAN
    Recommended name:
    Notch-regulated ankyrin repeat-containing protein
    Protein Accession:
    Q7Z6K4
    Secondary Accessions:
    • B8A4K5

    Protein attributes for NRARP Gene

    Size:
    114 amino acids
    Molecular mass:
    12492 Da
    Quaternary structure:
    • Interacts with LEF1.

neXtProt entry for NRARP Gene

Proteomics data for NRARP Gene at MOPED

Post-translational modifications for NRARP Gene

No Post-translational modifications

Other Protein References for NRARP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NRARP Gene

Domains & Families for NRARP Gene

Gene Families for NRARP Gene

Protein Domains for NRARP Gene

Suggested Antigen Peptide Sequences for NRARP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6K4

UniProtKB/Swiss-Prot:

NRARP_HUMAN :
  • Belongs to the NRARP family.
  • Contains 2 ANK repeats.
Family:
  • Belongs to the NRARP family.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with NRARP: view

Function for NRARP Gene

Molecular function for NRARP Gene

UniProtKB/Swiss-Prot Function:
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).
UniProtKB/Swiss-Prot Induction:
In endothelial cells by Notch signaling.
genes like me logo Genes that share phenotypes with NRARP: view

Animal Models for NRARP Gene

MGI Knock Outs for NRARP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NRARP Gene

Localization for NRARP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRARP Gene COMPARTMENTS Subcellular localization image for NRARP gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NRARP Gene

Pathways & Interactions for NRARP Gene

SuperPathways for NRARP Gene

Superpath Contained pathways
1 Notch Signaling Pathways
genes like me logo Genes that share pathways with NRARP: view

Pathways by source for NRARP Gene

1 R&D Systems pathway for NRARP Gene

SIGNOR curated interactions for NRARP Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NRARP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001569 patterning of blood vessels IEA,IBA --
GO:0001938 positive regulation of endothelial cell proliferation IEA,IBA --
GO:0002040 sprouting angiogenesis IEA --
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA,IBA --
genes like me logo Genes that share ontologies with NRARP: view

Drugs & Compounds for NRARP Gene

No Compound Related Data Available

Transcripts for NRARP Gene

mRNA/cDNA for NRARP Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(92) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NRARP Gene

NOTCH-regulated ankyrin repeat protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRARP Gene

No ASD Table

Relevant External Links for NRARP Gene

GeneLoc Exon Structure for
NRARP
ECgene alternative splicing isoforms for
NRARP

Expression for NRARP Gene

mRNA expression in normal human tissues for NRARP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRARP Gene

This gene is overexpressed in Colon - Transverse (x6.7).

SOURCE GeneReport for Unigene cluster for NRARP Gene Hs.732282

genes like me logo Genes that share expression patterns with NRARP: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NRARP Gene

Orthologs for NRARP Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRARP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRARP 35
  • 95.03 (n)
  • 98.25 (a)
NRARP 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRARP 35
  • 96.78 (n)
  • 98.25 (a)
NRARP 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrarp 35
  • 93.86 (n)
  • 100 (a)
Nrarp 16
Nrarp 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NRARP 35
  • 100 (n)
  • 100 (a)
NRARP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrarp 35
  • 93.27 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia NRARP 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRARP 35
  • 88.89 (n)
  • 88.6 (a)
NRARP 36
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nrarpa 35
  • 84.52 (n)
  • 90.18 (a)
nrarpa 36
  • 89 (a)
OneToMany
nrarpb 36
  • 87 (a)
OneToMany
Species with no ortholog for NRARP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRARP Gene

ENSEMBL:
Gene Tree for NRARP (if available)
TreeFam:
Gene Tree for NRARP (if available)

Paralogs for NRARP Gene

Paralogs for NRARP Gene

genes like me logo Genes that share paralogs with NRARP: view

Variants for NRARP Gene

Sequence variations from dbSNP and Humsavar for NRARP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs4075315 -- 137,299,289(-) GCACA(A/G)AAAGT downstream-variant-500B
rs4075316 -- 137,299,240(-) CTCCT(A/G)GCAGG downstream-variant-500B
rs6606557 -- 137,302,676(+) GAGGG(C/T)GACCT upstream-variant-2KB
rs6606558 -- 137,302,682(+) GACCT(A/C)TCCCG upstream-variant-2KB
rs6606559 -- 137,302,708(+) GGCAT(C/G)TCAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NRARP Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
nsv894631 CNV Loss 21882294
dgv8457n71 CNV Gain 21882294
nsv894637 CNV Loss 21882294
nsv894643 CNV Loss 21882294
dgv8458n71 CNV Loss 21882294
nsv894645 CNV Loss 21882294
nsv894646 CNV Loss 21882294
nsv825185 CNV Gain 20364138
nsv894649 CNV Loss 21882294
dgv8459n71 CNV Loss 21882294
nsv825189 CNV Gain 20364138
nsv825190 CNV Gain 20364138

Variation tolerance for NRARP Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRARP Gene

HapMap Linkage Disequilibrium report
NRARP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRARP Gene

Disorders for NRARP Gene

Relevant External Links for NRARP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRARP

No disorders were found for NRARP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRARP Gene

Publications for NRARP Gene

  1. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling. (PMID: 25985737) Zhu P. … Fan Z. (Nat. Commun. 2015) 3 4 67
  2. Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation. (PMID: 24778018) Imaoka T. … Shimada Y. (Anticancer Res. 2014) 3
  3. Expanding the substantial interactome of NEMO using protein microarrays. (PMID: 20098747) Fenner B.J. … Prehn J.H. (PLoS ONE 2010) 3
  4. Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. (PMID: 19154719) Phng L.K. … Gerhardt H. (Dev. Cell 2009) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for NRARP Gene

Sources for NRARP Gene

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