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NRAP Gene

protein-coding   GIFtS: 52
GCID: GC10M115338

Nebulin-Related Anchoring Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nebulin-Related Anchoring Protein1 2
N-RAP2 3
Nebulin-Related-Anchoring Protein2

External Ids:    HGNC: 79881   Entrez Gene: 48922   Ensembl: ENSG000001978937   OMIM: 6028735   UniProtKB: Q86VF73   

Export aliases for NRAP gene to outside databases

Previous GC identifers: GC10M114244 GC10M114582 GC10M115479 GC10M115013 GC10M108975


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NRAP Gene:
NRAP (nebulin-related anchoring protein) is a protein-coding gene. Diseases associated with NRAP include hypertrophic cardiomyopathy, and lateral sclerosis. GO annotations related to this gene include muscle alpha-actinin binding and actin binding. An important paralog of this gene is LASP1.

UniProtKB/Swiss-Prot: NRAP_HUMAN, Q86VF7
Function: May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in
transmitting tension from the myofibrils to the extracellular matrix (By similarity)

Gene Wiki entry for NRAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NRAP gene promoter:
         MEF-2A   AP-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNRAP promoter sequence
   Search Chromatin IP Primers for NRAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24-q26   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q24-q26

NRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NRAP gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M115338:  view genomic region     (about GC identifiers)

Start:
115,348,475 bp from pter      End:
115,423,886 bp from pter
Size:
75,412 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NRAP_HUMAN, Q86VF7 (See protein sequence)
Recommended Name: Nebulin-related-anchoring protein  
Size: 1730 amino acids; 197074 Da
Subunit: Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL (By similarity)
Sequence caution: Sequence=AAH58825.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH70130.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAQ09536.1; Type=Erroneous initiation; Sequence=BAC04884.1; Type=Erroneous initiation;
Secondary accessions: O15500 Q5VWI3 Q5VWI4 Q6MZK3 Q6N026 Q6N059 Q6NSH8 Q6PDB0 Q719H6 Q86TC5
Q86TD6 Q86TE6 Q86VF6 Q8N3R6 Q8N8F9 Q8TCH0 Q96MG4
Alternative splicing: 4 isoforms:  Q86VF7-1   Q86VF7-2   Q86VF7-3   Q86VF7-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for NRAP: NX_Q86VF7

Explore proteomics data for NRAP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NRAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001248392.1  NP_006166.3  NP_932326.2  

    ENSEMBL proteins: 
     ENSP00000358367   ENSP00000353078   ENSP00000353666   ENSP00000358365  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000900 Nebulin_repeat
     IPR028447 N-RAP
     IPR001781 Znf_LIM
     IPR013998 Nebulin

    Graphical View of Domain Structure for InterPro Entry Q86VF7

    ProtoNet protein and cluster: Q86VF7

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: NRAP_HUMAN, Q86VF7
    Similarity: Contains 1 LIM zinc-binding domain
    Similarity: Contains 44 nebulin repeats


    NRAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NRAP_HUMAN, Q86VF7
    Function: May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in
    transmitting tension from the myofibrils to the extracellular matrix (By similarity)

         Genatlas biochemistry entry for NRAP:
    nebulin-related actin binding protein,expressed exclusively in striated muscle

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding NAS9339382
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0017166vinculin binding IEA--
    GO:0051371muscle alpha-actinin binding ISS--
         
    NRAP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NRAP
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NRAP_HUMAN, Q86VF7: Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk
    in cardiac muscle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005916fascia adherens ISS--
    GO:0005927muscle tendon junction ISS--
    GO:0030016myofibril IEA--

    NRAP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NRAP
    Interactions:

        GeneGlobe Interaction Network for NRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NRAP (Q86VF73 ENSP000003530784) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCLP182063, ENSP000002119984I2D: score=2 STRING: ENSP00000211998
    ACTA1P681333, ENSP000003556454I2D: score=1 STRING: ENSP00000355645
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    KLHL41O606623, ENSP000002846694I2D: score=1 STRING: ENSP00000284669
    TLN1Q9Y4903, ENSP000003160294I2D: score=1 STRING: ENSP00000316029
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0030036actin cytoskeleton organization ----

    NRAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NRAP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NRAP gene (3 alternative transcripts): 
    NM_001261463.1  NM_006175.4  NM_198060.3  

    Unigene Cluster for NRAP:

    Nebulin-related anchoring protein
    Hs.268788  [show with all ESTs]
    Unigene Representative Sequence: BX640730
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369360(uc009xyb.3 uc001lak.3) ENST00000359988(uc001laj.3 uc001lal.3)
    ENST00000360478 ENST00000369358

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidNRAP 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NRAP
      QuantiTect SYBR Green Assays in human, mouse, rat NRAP
      QuantiFast Probe-based Assays in human, mouse, rat NRAP

    Additional mRNA sequence: 

    AF542553.1 AK056605.1 AK056969.1 AK096875.1 AK096886.1 AL831980.2 AL832025.2 AL832330.2 
    AL832457.3 AY081943.2 AY177620.1 AY177621.1 BC005933.1 BC017866.1 BC058825.1 BC070130.1 
    BC126407.1 BC143751.1 BX640682.2 BX640730.1 BX641052.1 BX647658.1 

    7 DOTS entries:

    DT.91775380  DT.111537  DT.101985309  DT.304542  DT.100789917  DT.92416784  DT.99981377 

    Selected AceView cDNA sequences (see all 141):

    AY177620 AJ711969 F25153 NM_006175 F30818 F17933 AA176595 AJ346143 
    AY177621 BQ954264 F20620 F20589 F31637 AF542553 F29371 C02691 
    AA180013 AA176955 BX500384 Z36252 AJ572712 AK096886 F26078 F19086 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NRAP (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for NRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NRAP expression in normal human tissues (normalized intensities)      NRAP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCACCCTGA
    NRAP Expression
    About this image


    NRAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Skeletal Muscle (Muscoskeletal System)
    NRAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NRAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268788

    UniProtKB/Swiss-Prot: NRAP_HUMAN, Q86VF7
    Tissue specificity: Expressed in cardiac and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NRAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NRAP gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nrap1 , 5 nebulin-related anchoring protein1, 5 85.26(n)1
    86.23(a)1
      19 (51.80 cM)5
    181751  NM_008733.41  NP_032759.31 
     563200355 
    chicken
    (Gallus gallus)
    Aves NRAP1 nebulin-related anchoring protein 74.16(n)
    72.77(a)
      423899  XM_003641526.2  XP_003641574.1 
    lizard
    (Anolis carolinensis)
    Reptilia NRAP6
    nebulin-related anchoring protein
    72(a)
    1 ↔ 1
    GL343204.1(640233-728265)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nrap1 nebulin-related anchoring protein 69.12(n)
    66.26(a)
      100487160  XM_002939500.2  XP_002939546.2 
    zebrafish
    (Danio rerio)
    Actinopterygii NRAP6
    nebulin-related anchoring protein
    57(a)
    1 ↔ 1
    12(32250714-32282561) ENSDARG00000009341
    worm
    (Caenorhabditis elegans)
    Secernentea F42H10.36
    Protein F42H10.3, isoform a (F42H10.3) mRNA, compl...
    19(a)
    1 → many
    III(8484158-8488365) WBGene00018367


    ENSEMBL Gene Tree for NRAP (if available)
    TreeFam Gene Tree for NRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NRAP gene
    LASP12  NEB2  NEBL2  
    3 SIMAP similar genes for NRAP using alignment to 4 protein entries:     NRAP_HUMAN (see all proteins):
    NEB    CRIP1    CRIP2

    NRAP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NRAP (see all 2100)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411485271,2
    Cuntested1115350589(+) TCGTCG/AACACT 6 /V syn11Minor allele frequency- A:0.00NA 4552
    rs1416341971,2
    --115349916(+) TGGGTG/TAATAG 3 -- int10--------
    rs115756901,2
    C,F,H--115349933(+) TCCCTT/CGGAAA 3 -- int115Minor allele frequency- C:0.01NS EA NA 1284
    rs115757931,2
    C,F--115350047(+) TGAACC/GTCTCT 3 -- int12Minor allele frequency- G:0.01NS 90
    rs70898831,2
    C,F,A,H--115350100(+) TTGGCA/GTAAGT 3 -- int114Minor allele frequency- G:0.31NS NA WA CSA EA 702
    rs115757941,2
    C,F,H--115350143(+) ACAGAG/ACCTGG 3 -- int19Minor allele frequency- A:0.04NS EA WA CSA 621
    rs1491943991,2
    C--115350170(+) GAGAA-/GTGGTGGT 3 -- int10--------
    rs115757951,2
    F--115350175(+) GTGGTGGT/-TATTA 3 -- int12Minor allele frequency- -:0.04NS 90
    rs115757961,2
    C,F,H--115350264(+) GGAACG/ATGGCA 3 -- int16Minor allele frequency- A:0.00NS EA 506
    rs1445082701,2
    C--115350299(+) CACCAA/GGGGAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for NRAP (115348475 - 115423886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NRAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273918CNV Insertion20981092
    nsv522830CNV Loss19592680
    nsv7555CNV Loss18451855
    nsv526006CNV Loss19592680
    dgv822n71CNV Loss21882294
    nsv896015CNV Gain21882294
    nsv7211OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602873    OMIM disorders: --

    4 diseases for NRAP:    About MalaCards
    hypertrophic cardiomyopathy    lateral sclerosis    amyotrophic lateral sclerosis    alzheimer's disease


    NRAP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NRAP
    Human Genome Epidemiology (HuGE) Navigator: NRAP (3 documents)

    Export disorders for NRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NRAP gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with NRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, alternative splicing, and expression of human and mouse N-RAP, a nebulin-related LIM protein of striated muscle. (PubMed id 12789664)1, 2, 3, 9 Mohiddin S.A....Fananapazir L. (Cell Motil. Cytoskeleton 2003)
    2. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. (PubMed id 10320340)1, 3, 9 Luo G.... Horowits R. (Biochemistry 1999)
    3. Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes. (PubMed id 9339382)1, 2, 9 Luo G.... Horowits R. (Genomics 1997)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)1, 4 Chen X....Kong X. (PLoS ONE 2010)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. Complete cDNA sequence and tissue localization of N-RAP, a novel nebulin-related protein of striated muscle. (PubMed id 9295142)1, 9 Luo G....Horowits R. (Cell Motil. Cytoskeleton 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4892 HGNC: 7988 AceView: NRAP Ensembl:ENSG00000197893 euGenes: HUgn4892
    ECgene: NRAP H-InvDB: NRAP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NRAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NRAP gene:
    Search GeneIP for patents involving NRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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