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Aliases for NRAP Gene

Aliases for NRAP Gene

  • Nebulin-Related Anchoring Protein 2 3
  • N-RAP 3 4
  • Nebulin-Related-Anchoring Protein 3

External Ids for NRAP Gene

Previous GeneCards Identifiers for NRAP Gene

  • GC10M114244
  • GC10M114582
  • GC10M115479
  • GC10M115013
  • GC10M115338
  • GC10M108975

Summaries for NRAP Gene

GeneCards Summary for NRAP Gene

NRAP (Nebulin-Related Anchoring Protein) is a Protein Coding gene. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is NEBL.

UniProtKB/Swiss-Prot for NRAP Gene

  • May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.

Gene Wiki entry for NRAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRAP Gene

Genomics for NRAP Gene

Regulatory Elements for NRAP Gene

Genomic Location for NRAP Gene

Start:
113,588,716 bp from pter
End:
113,664,127 bp from pter
Size:
75,412 bases
Orientation:
Minus strand

Genomic View for NRAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRAP Gene

Proteins for NRAP Gene

  • Protein details for NRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VF7-NRAP_HUMAN
    Recommended name:
    Nebulin-related-anchoring protein
    Protein Accession:
    Q86VF7
    Secondary Accessions:
    • O15500
    • Q5VWI3
    • Q5VWI4
    • Q6MZK3
    • Q6N026
    • Q6N059
    • Q6NSH8
    • Q6PDB0
    • Q719H6
    • Q86TC5
    • Q86TD6
    • Q86TE6
    • Q86VF6
    • Q8N3R6
    • Q8N8F9
    • Q8TCH0
    • Q96MG4

    Protein attributes for NRAP Gene

    Size:
    1730 amino acids
    Molecular mass:
    197074 Da
    Quaternary structure:
    • Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL.
    SequenceCaution:
    • Sequence=AAH58825.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70130.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAQ09536.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRAP Gene

Proteomics data for NRAP Gene at MOPED

Post-translational modifications for NRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NRAP Gene

No data available for DME Specific Peptides for NRAP Gene

Domains for NRAP Gene

Protein Domains for NRAP Gene

Suggested Antigen Peptide Sequences for NRAP Gene

Graphical View of Domain Structure for InterPro Entry

Q86VF7

UniProtKB/Swiss-Prot:

NRAP_HUMAN :
  • Q86VF7
Domain:
  • Contains 1 LIM zinc-binding domain.
Similarity:
  • Contains 44 nebulin repeats.
genes like me logo Genes that share domains with NRAP: view

No data available for Gene Families for NRAP Gene

Function for NRAP Gene

Molecular function for NRAP Gene

GENATLAS Biochemistry: nebulin-related actin binding protein,expressed exclusively in striated muscle
UniProtKB/Swiss-Prot Function: May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.

Gene Ontology (GO) - Molecular Function for NRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 9339382
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0017166 vinculin binding --
GO:0051371 muscle alpha-actinin binding ISS --
genes like me logo Genes that share ontologies with NRAP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NRAP Gene

Localization for NRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRAP Gene

Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. .

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRAP Gene COMPARTMENTS Subcellular localization image for NRAP gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005916 fascia adherens ISS --
GO:0005927 muscle tendon junction ISS --
GO:0030016 myofibril --
genes like me logo Genes that share ontologies with NRAP: view

Pathways for NRAP Gene

SuperPathways for NRAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRAP: view

No data available for Pathways by source for NRAP Gene

Transcripts for NRAP Gene

Unigene Clusters for NRAP Gene

Nebulin-related anchoring protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NRAP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NRAP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for NRAP Gene

GeneLoc Exon Structure for
NRAP
ECgene alternative splicing isoforms for
NRAP

Expression for NRAP Gene

mRNA expression in normal human tissues for NRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRAP Gene

This gene is overexpressed in Muscle - Skeletal (35.2) and Heart - Left Ventricle (13.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NRAP Gene

SOURCE GeneReport for Unigene cluster for NRAP Gene Hs.268788

mRNA Expression by UniProt/SwissProt for NRAP Gene

Q86VF7-NRAP_HUMAN
Tissue specificity: Expressed in cardiac and skeletal muscle.
genes like me logo Genes that share expressions with NRAP: view

In Situ Assay Products

Orthologs for NRAP Gene

This gene was present in the common ancestor of animals.

Orthologs for NRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRAP 35
  • 99.4 (n)
  • 98.96 (a)
NRAP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRAP 35
  • 89.48 (n)
  • 90.87 (a)
NRAP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRAP 35
  • 90.49 (n)
  • 91.9 (a)
NRAP 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrap 35
  • 85.26 (n)
  • 86.23 (a)
Nrap 16
Nrap 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRAP 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRAP 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrap 35
  • 85.27 (n)
  • 86.86 (a)
chicken
(Gallus gallus)
Aves NRAP 35
  • 74.16 (n)
  • 72.77 (a)
NRAP 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRAP 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrap 35
  • 69.12 (n)
  • 66.26 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6755 35
zebrafish
(Danio rerio)
Actinopterygii NRAP 36
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F42H10.3 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for NRAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRAP Gene

ENSEMBL:
Gene Tree for NRAP (if available)
TreeFam:
Gene Tree for NRAP (if available)

Paralogs for NRAP Gene

Paralogs for NRAP Gene

Selected SIMAP similar genes for NRAP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRAP: view

Variants for NRAP Gene

Sequence variations from dbSNP and Humsavar for NRAP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1140 -- 113,594,813(-) CTACC(A/G)TTCAC intron-variant
rs713585 -- 113,624,354(-) CTATA(C/T)ATCAA intron-variant
rs868738 - 113,621,988(-) ATGCC(C/T)GCAAA reference, missense
rs885567 -- 113,597,420(+) TACTA(C/T)GGCTC intron-variant
rs1014033 -- 113,597,732(-) CATTT(C/T)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRAP Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
dgv822n71 CNV Loss 21882294
nsv7555 CNV Loss 18451855
nsv896015 CNV Gain 21882294
nsv522830 CNV Loss 19592680
esv273918 CNV Insertion 20981092
nsv526006 CNV Loss 19592680

Relevant External Links for NRAP Gene

HapMap Linkage Disequilibrium report
NRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRAP Gene

Disorders for NRAP Gene

Relevant External Links for NRAP

Genetic Association Database (GAD)
NRAP
Human Genome Epidemiology (HuGE) Navigator
NRAP
genes like me logo Genes that share disorders with NRAP: view

No data available for UniProtKB/Swiss-Prot for NRAP Gene

Publications for NRAP Gene

  1. Genomic organization, alternative splicing, and expression of human and mouse N-RAP, a nebulin-related LIM protein of striated muscle. (PMID: 12789664) Mohiddin S.A. … Fananapazir L. (Cell Motil. Cytoskeleton 2003) 2 3 4 23
  2. Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes. (PMID: 9339382) Luo G. … Horowits R. (Genomics 1997) 3 4 23
  3. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. (PMID: 10320340) Luo G. … Horowits R. (Biochemistry 1999) 2 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for NRAP Gene

Sources for NRAP Gene

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