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Aliases for NRAP Gene

Aliases for NRAP Gene

  • Nebulin Related Anchoring Protein 2 3 5
  • N-RAP 3 4
  • Nebulin-Related Anchoring Protein 2
  • Nebulin-Related-Anchoring Protein 3

External Ids for NRAP Gene

Previous GeneCards Identifiers for NRAP Gene

  • GC10M114244
  • GC10M114582
  • GC10M115479
  • GC10M115013
  • GC10M115338
  • GC10M108975

Summaries for NRAP Gene

GeneCards Summary for NRAP Gene

NRAP (Nebulin Related Anchoring Protein) is a Protein Coding gene. Diseases associated with NRAP include Myopathy, Myofibrillar, 5. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is NEB.

UniProtKB/Swiss-Prot for NRAP Gene

  • May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.

Gene Wiki entry for NRAP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRAP Gene

Genomics for NRAP Gene

Regulatory Elements for NRAP Gene

Enhancers for NRAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F113788 1.1 Ensembl ENCODE 9.8 -124.8 -124834 1.1 BMI1 ETV6 FOS CREM CBFB JUNB MAFF SMARCA4 IKZF1 STAT3 CASP7 ENSG00000234393 RNU6-709P PLEKHS1 ADRB1 NRAP MIR4483 ENSG00000212589
GH10F113736 0.7 Ensembl 9.9 -72.0 -71974 0.2 CTCF NFIA HLF CEBPB CEBPG RAD21 ATF4 HNF1A ATF3 CEBPA NRAP PLEKHS1 ENSG00000234393
GH10F113539 0.7 Ensembl 9.6 +124.3 124327 0.8 GATAD2A FOXA3 JUND ZFHX2 ATF3 ZKSCAN8 CEBPA PRDM10 ZNF548 EGR2 NHLRC2 NRAP HABP2 ENSG00000230018
GH10F114356 0.7 Ensembl ENCODE 9 -693.0 -692996 1.0 JUND ZFHX2 IKZF1 ABLIM1 TDRD1 NRAP GC10P114357 LOC105378494
GH10F113750 0.6 ENCODE 9.4 -88.8 -88768 5.2 STAT1 PKNOX1 PBX2 ZNF133 USF2 CASP7 ENSG00000234393 NRAP PLEKHS1 MIR4483
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NRAP on UCSC Golden Path with GeneCards custom track

Genomic Location for NRAP Gene

Chromosome:
10
Start:
113,588,716 bp from pter
End:
113,664,127 bp from pter
Size:
75,412 bases
Orientation:
Minus strand

Genomic View for NRAP Gene

Genes around NRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRAP Gene

Proteins for NRAP Gene

  • Protein details for NRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VF7-NRAP_HUMAN
    Recommended name:
    Nebulin-related-anchoring protein
    Protein Accession:
    Q86VF7
    Secondary Accessions:
    • O15500
    • Q5VWI3
    • Q5VWI4
    • Q6MZK3
    • Q6N026
    • Q6N059
    • Q6NSH8
    • Q6PDB0
    • Q719H6
    • Q86TC5
    • Q86TD6
    • Q86TE6
    • Q86VF6
    • Q8N3R6
    • Q8N8F9
    • Q8TCH0
    • Q96MG4

    Protein attributes for NRAP Gene

    Size:
    1730 amino acids
    Molecular mass:
    197074 Da
    Quaternary structure:
    • Interacts with actin, alpha-actinin, KLHL41, TLN1 and VCL. Interacts with CSRP3.
    SequenceCaution:
    • Sequence=AAH58825.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70130.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAQ09536.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRAP Gene

Post-translational modifications for NRAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NRAP Gene

Domains & Families for NRAP Gene

Gene Families for NRAP Gene

Protein Domains for NRAP Gene

Suggested Antigen Peptide Sequences for NRAP Gene

Graphical View of Domain Structure for InterPro Entry

Q86VF7

UniProtKB/Swiss-Prot:

NRAP_HUMAN :
  • Contains 1 LIM zinc-binding domain.
  • Contains 44 nebulin repeats.
Domain:
  • Contains 1 LIM zinc-binding domain.
Similarity:
  • Contains 44 nebulin repeats.
genes like me logo Genes that share domains with NRAP: view

Function for NRAP Gene

Molecular function for NRAP Gene

GENATLAS Biochemistry:
nebulin-related actin binding protein,expressed exclusively in striated muscle
UniProtKB/Swiss-Prot Function:
May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix.

Gene Ontology (GO) - Molecular Function for NRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 9339382
GO:0005515 protein binding IPI 15205937
GO:0008270 zinc ion binding IEA --
GO:0017166 vinculin binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NRAP: view

Phenotypes for NRAP Gene

GenomeRNAi human phenotypes for NRAP:
genes like me logo Genes that share phenotypes with NRAP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRAP Gene

Localization for NRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRAP Gene

Note=Localized at the myotendinous junction in skeletal muscle and at the intercalated disk in cardiac muscle. .

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NRAP gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for NRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005916 fascia adherens IEA,ISS --
GO:0005927 muscle tendon junction IEA,ISS --
GO:0030016 myofibril IEA --
genes like me logo Genes that share ontologies with NRAP: view

Pathways & Interactions for NRAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for NRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NRAP: view

No data available for Pathways by source and SIGNOR curated interactions for NRAP Gene

Transcripts for NRAP Gene

Unigene Clusters for NRAP Gene

Nebulin-related anchoring protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NRAP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b · 30c ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for NRAP Gene

GeneLoc Exon Structure for
NRAP
ECgene alternative splicing isoforms for
NRAP

Expression for NRAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NRAP Gene

This gene is overexpressed in Muscle - Skeletal (x35.2) and Heart - Left Ventricle (x13.2).

Protein differential expression in normal tissues from HIPED for NRAP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (28.8), Heart (13.3), Spinal cord (12.0), and Brain (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NRAP Gene



NURSA nuclear receptor signaling pathways regulating expression of NRAP Gene:

NRAP

SOURCE GeneReport for Unigene cluster for NRAP Gene:

Hs.268788

mRNA Expression by UniProt/SwissProt for NRAP Gene:

Q86VF7-NRAP_HUMAN
Tissue specificity: Expressed in cardiac and skeletal muscle.
genes like me logo Genes that share expression patterns with NRAP: view

Primer Products

No data available for Protein tissue co-expression partners for NRAP Gene

Orthologs for NRAP Gene

This gene was present in the common ancestor of animals.

Orthologs for NRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRAP 34 35
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia NRAP 34 35
  • 90.49 (n)
cow
(Bos Taurus)
Mammalia NRAP 34 35
  • 89.48 (n)
rat
(Rattus norvegicus)
Mammalia Nrap 34
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Nrap 34 16 35
  • 85.26 (n)
oppossum
(Monodelphis domestica)
Mammalia NRAP 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRAP 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NRAP 34 35
  • 74.16 (n)
lizard
(Anolis carolinensis)
Reptilia NRAP 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nrap 34
  • 69.12 (n)
zebrafish
(Danio rerio)
Actinopterygii NRAP 35
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6755 34
worm
(Caenorhabditis elegans)
Secernentea F42H10.3 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for NRAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NRAP Gene

ENSEMBL:
Gene Tree for NRAP (if available)
TreeFam:
Gene Tree for NRAP (if available)

Paralogs for NRAP Gene

Paralogs for NRAP Gene

(3) SIMAP similar genes for NRAP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NRAP: view

Variants for NRAP Gene

Sequence variations from dbSNP and Humsavar for NRAP Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1014033 -- 113,597,732(-) CATTT(C/T)GTACA intron-variant
rs10430682 -- 113,662,130(+) AGTCA(C/T)ATTTG intron-variant
rs10430683 -- 113,662,518(+) CCCAA(A/G)CTCAA intron-variant
rs10509982 -- 113,617,744(+) TGTCA(A/C)TTAAC intron-variant
rs10509983 -- 113,636,446(+) GCAAC(C/T)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRAP Gene

Variant ID Type Subtype PubMed ID
nsv7555 CNV deletion 18451855
nsv7211 OTHER inversion 18451855
nsv526006 CNV loss 19592680
nsv522830 CNV loss 19592680
nsv1048819 CNV gain 25217958
esv3624604 CNV gain 21293372
esv3624603 CNV gain 21293372
esv3577738 CNV gain 25503493
esv3428654 CNV insertion 20981092
esv3380212 CNV insertion 20981092
esv3309646 CNV mobile element insertion 20981092

Variation tolerance for NRAP Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 32.12; 99.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NRAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRAP Gene

Disorders for NRAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for NRAP Gene - From: DISEASES

Disorder Aliases PubMed IDs
myopathy, myofibrillar, 5
  • myofibrillar myopathy 5
- elite association - COSMIC cancer census association via MalaCards
Search NRAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for NRAP

Genetic Association Database (GAD)
NRAP
Human Genome Epidemiology (HuGE) Navigator
NRAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRAP
genes like me logo Genes that share disorders with NRAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NRAP Gene

Publications for NRAP Gene

  1. Genomic organization, alternative splicing, and expression of human and mouse N-RAP, a nebulin-related LIM protein of striated muscle. (PMID: 12789664) Mohiddin S.A. … Fananapazir L. (Cell Motil. Cytoskeleton 2003) 2 3 4 22 64
  2. Decreased interactions of mutant muscle LIM protein (MLP) with N-RAP and alpha-actinin and their implication for hypertrophic cardiomyopathy. (PMID: 15205937) Gehmlich K. … FA1rst D.O. (Cell Tissue Res. 2004) 3 4 22 64
  3. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. (PMID: 10320340) Luo G. … Horowits R. (Biochemistry 1999) 2 3 22 64
  4. Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes. (PMID: 9339382) Luo G. … Horowits R. (Genomics 1997) 3 4 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for NRAP Gene

Sources for NRAP Gene

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