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Aliases for NRADDP Gene

Aliases for NRADDP Gene

  • Neurotrophin Receptor Associated Death Domain, Pseudogene 2 3

External Ids for NRADDP Gene

Summaries for NRADDP Gene

Entrez Gene Summary for NRADDP Gene

  • The neurotrophin receptor alike death domain proteins belong to the death domain superfamily and are involved in mediating apoptosis. This gene has been inactivated by mutation and is nonfunctional in humans. [provided by RefSeq, Oct 2008]

GeneCards Summary for NRADDP Gene

NRADDP (Neurotrophin Receptor Associated Death Domain, Pseudogene) is a Pseudogene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRADDP Gene

Genomics for NRADDP Gene

Genomic Location for NRADDP Gene

Chromosome:
3
Start:
47,011,542 bp from pter
End:
47,013,467 bp from pter
Size:
1,926 bases
Orientation:
Plus strand

Genomic View for NRADDP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for NRADDP Gene

No data available for Regulatory Elements for NRADDP Gene

Proteins for NRADDP Gene

Post-translational modifications for NRADDP Gene

No Post-translational modifications

No data available for DME Specific Peptides for NRADDP Gene

Domains & Families for NRADDP Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NRADDP Gene

Function for NRADDP Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NRADDP Gene

Localization for NRADDP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NRADDP Gene

Pathways & Interactions for NRADDP Gene

SuperPathways for NRADDP Gene

No Data Available

Interacting Proteins for NRADDP Gene

Gene Ontology (GO) - Biological Process for NRADDP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NRADDP Gene

Drugs & Compounds for NRADDP Gene

No Compound Related Data Available

Transcripts for NRADDP Gene

mRNA/cDNA for NRADDP Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NRADDP Gene

Neurotrophin receptor associated death domain, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRADDP Gene

No ASD Table

Relevant External Links for NRADDP Gene

GeneLoc Exon Structure for
NRADDP
ECgene alternative splicing isoforms for
NRADDP

Expression for NRADDP Gene

mRNA expression in normal human tissues for NRADDP Gene

mRNA differential expression in normal tissues according to GTEx for NRADDP Gene

This gene is overexpressed in Whole Blood (x8.2), Skin - Not Sun Exposed (Suprapubic) (x5.3), and Esophagus - Mucosa (x4.5).

SOURCE GeneReport for Unigene cluster for NRADDP Gene Hs.201522

genes like me logo Genes that share expression patterns with NRADDP: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NRADDP Gene

Orthologs for NRADDP Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for NRADDP Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Nradd 16
Species with no ortholog for NRADDP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NRADDP Gene

ENSEMBL:
Gene Tree for NRADDP (if available)
TreeFam:
Gene Tree for NRADDP (if available)

Paralogs for NRADDP Gene

No data available for Paralogs for NRADDP Gene

Variants for NRADDP Gene

Sequence variations from dbSNP and Humsavar for NRADDP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs936186 -- 47,011,527(+) TATTA(A/C/T)CCACT upstream-variant-2KB
rs1013448 -- 47,013,276(+) GGGAA(G/T)AAAAC nc-transcript-variant
rs1982510 -- 47,011,447(+) GAGAG(A/C)AGCAG upstream-variant-2KB
rs2278963 -- 47,013,379(+) TTCTG(A/C)CCTTT nc-transcript-variant
rs35407196 -- 47,013,072(+) GCTAG(-/T)AGAAT nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NRADDP Gene

Variant ID Type Subtype PubMed ID
nsv428417 CNV Loss 18775914
nsv876755 CNV Loss 21882294
nsv876756 CNV Gain 21882294
nsv876757 CNV Loss 21882294

Relevant External Links for NRADDP Gene

HapMap Linkage Disequilibrium report
NRADDP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NRADDP Gene

Disorders for NRADDP Gene

Relevant External Links for NRADDP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NRADDP
genes like me logo Genes that share disorders with NRADDP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NRADDP Gene

Publications for NRADDP Gene

  1. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 2 67
  2. Comparative genomics search for losses of long-established genes on the human lineage. (PMID: 18085818) Zhu J. … Haussler D. (PLoS Comput. Biol. 2007) 2 67
  3. NRADD, a novel membrane protein with a death domain involved in mediating apoptosis in response to ER stress. (PMID: 12728256) Wang X. … Vincenz C. (Cell Death Differ. 2003) 67
  4. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. (PMID: 12095158) Frankowski H. … Bredesen D.E. (Neuromolecular Med. 2002) 67

Products for NRADDP Gene

Sources for NRADDP Gene

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