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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NR6A1 Gene

protein-coding GIFtS: 62
GCID: GC09M127279

nuclear receptor subfamily 6, group A, member 1

(Previous symbol: GCNF)

Explore 16 diseases affiliated with
NR6A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 6, Group A, Member 1¹ ²		HRTR¹
GCNF¹ ² ³ ⁵		NR61²
RTR¹ ² ³		Germ Cell Nuclear Factor Variant 1²
GCNF1¹ ²		Nuclear Receptor Subfamily 6 Group A Member 1²
Retinoid Receptor-Related Testis-Specific Receptor² ³		Retinoic Acid Receptor-Related Testis-Associated Receptor²
HGCNF¹		Germ Cell Nuclear Factor³

External Ids:	HGNC: 7985¹	Entrez Gene: 2649²	Ensembl: ENSG00000148200⁷	OMIM: 602778⁵	UniProtKB: Q15406³

Export aliases for NR6A1 gene to outside databases

Previous GC identifers: GC09M118397 GC09M118928 GC09M120736 GC09M122658 GC09M124361 GC09M126319 GC09M096897

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR6A1:

This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression

pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and

bind DNA, but in vivo targets have not been identified. The gene expresses at least alternatively spliced transcript

variants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NR6A1_HUMAN, Q15406

Function: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved

in the regulation of gene expression in germ cell development during gametogenesis (By similarity)

Gene Wiki entry for NR6A1 (Germ cell nuclear factor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NR6A1 gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NR6A1 promoter sequence

Search SABiosciences Chromatin IP Primers for NR6A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR6A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q33.3

NR6A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR6A1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M127279: view genomic region (about GC identifiers)

Start:	127,279,888 bp from pter	End:	127,533,589 bp from pter
Size:	253,702 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NR6A1_HUMAN, Q15406 (See protein sequence)

Recommended Name: Nuclear receptor subfamily 6 group A member 1

Size: 480 amino acids; 54383 Da

Subunit: Homodimer. Interacts with UIMC1 (By similarity)

Subcellular location: Nucleus (Probable)

Secondary accessions: O00551 O00603 Q5T6F4 Q8NHQ0 Q92898 Q99802

Alternative splicing: 5 isoforms: Q15406-1 Q15406-2 Q15406-3 Q15406-4 Q15406-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NR6A1: NX_Q15406

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15406

NR6A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001480.3 NP_201591.2

ENSEMBL proteins:

ENSP00000420267 ENSP00000362686 ENSP00000413701 ENSP00000341135 ENSP00000420587

Reactome Protein details: Q15406
Human Recombinant Protein Products for NR6A1:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NR6A1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	ISS	--

NR6A1 for ontologies About GeneDecksing

NR6A1 Antibody Products:

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Assay Products for NR6A1:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for NR6A1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NR6A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NR6A1 for domains About GeneDecksing

5 InterPro domains/families:

IPR013088 Znf_NHR/GATA

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

IPR001628 Znf_hrmn_rcpt

IPR001723 Str_hrmn_rcpt

Graphical View of Domain Structure for InterPro Entry Q15406

ProtoNet protein and cluster: Q15406

2 Blocks protein families:

IPB000324 Vitamin D receptor signature

IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: NR6A1_HUMAN, Q15406

Similarity: Belongs to the nuclear hormone receptor family. NR6 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NR6A1_HUMAN, Q15406

Function: Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved

in the regulation of gene expression in germ cell development during gametogenesis (By similarity)

Genatlas biochemistry entry for NR6A1:

nuclear receptor subfamily 6,group A,member 1,steroid/thyroid receptor superfamily,potentially involved in

spermatogenic maturation

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	ISS	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	TAS	9134503
GO:0005515	protein binding	--	--

NR6A1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NR6A1:

Upregulation of Wnt/beta-caten

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Nr6a1):

cardiovascular system	digestive/alimentary	embryogenesis	endocrine/exocrine gland	homeostasis/metabolism
mortality/aging	nervous system	reproductive system	skeleton

NR6A1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for NR6A1: Nr6a1^tm1Coo Nr6a1^tm2Coo

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NR6A1

		10/431 SABiosciences Target genes for NR6A1 (see all 431):
		AAMP ACP5 ADCY9 AGPAT6 AKAP10 AKAP8L ALAS2 ALDH7A1 ALG13 ALKBH4

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NR6A1 Browse MicroRNA Expression Plasmids
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		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate NR6A1 (see all 16):
		hsa-miR-3607-3p hsa-miR-495 hsa-miR-181c hsa-miR-3664-5p hsa-miR-4272 hsa-miR-23a hsa-miR-3662 hsa-miR-181b

		SwitchGear 3'UTR luciferase reporter plasmid: NR6A1 3' UTR sequence

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR6A1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR6A1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NR6A1 (NM_033334)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NR6A1
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR6A1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Meiosis

Meiosis

1.00

Oct4 in Mammalian ESC Pluripotency

Oct4 in Mammalian ESC Pluripotency

1.00

Nuclear Receptor transcription pathway

Nuclear Receptor transcription pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NR6A1

Meiosis

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NR6A1

Oct4 in Mammalian ESC Pluripotency

1 Cell Signaling Technology (CST) Pathway for NR6A1

Wnt / Hedgehog / Notch

3 Reactome Pathways for NR6A1

	Generic Transcription Pathway
	Nuclear Receptor transcription pathway
	Gene Expression

NR6A1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NR6A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/11 Interacting proteins for NR6A1 (Q15406^{2, 3} ENSP00000420267⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNB5	O14775²^,³, ENSP00000261837⁴	MINT-63075 I2D: score=4 STRING: ENSP00000261837
DNMT3A	Q9Y6K1³, ENSP00000264709⁴	I2D: score=1 STRING: ENSP00000264709
UIMC1	Q96RL1³, ENSP00000366434⁴	I2D: score=2 STRING: ENSP00000366434
NCOR1	O75376³, ENSP00000268712⁴	I2D: score=1 STRING: ENSP00000268712
DNMT3B	Q9UBC3³, ENSP00000328547⁴	I2D: score=1 STRING: ENSP00000328547

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0006351	transcription, DNA-dependent	--	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0007276	gamete generation	ISS	--
GO:0007283	spermatogenesis	TAS	9134503

NR6A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NR6A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NR6A1
5 Novoseek chemical compound relationships for NR6A1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	63.4	24	20463469 (2), 19439415 (2), 19587013 (2), 12023888 (1) (see all 15)
retinoid	52.5	11	9134503 (2), 10940306 (2), 16155958 (1)
protamine	37.7	3	11578963 (2), 11606249 (1)
estrogen	19	1	10940306 (1)
cholesterol	0	1	12467566 (1)

Search CenterWatch for drugs/clinical trials and news about NR6A1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NR6A1 gene (3 alternative transcripts):

NM_001489.3 NM_033334.2 NM_033335.2

Unigene Cluster for NR6A1:

Nuclear receptor subfamily 6, group A, member 1

Hs.586460 [show with all ESTs]

Unigene Representative Sequence: BC030600

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000487099 ENST00000373584(uc004boq.1 uc004bor.1 uc010mwq.1)

ENST00000416460 ENST00000344523 ENST00000475178

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		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate NR6A1 (see all 16):
		hsa-miR-3607-3p hsa-miR-495 hsa-miR-181c hsa-miR-3664-5p hsa-miR-4272 hsa-miR-23a hsa-miR-3662 hsa-miR-181b

		SwitchGear 3'UTR luciferase reporter plasmid: NR6A1 3' UTR sequence

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Additional cDNA sequence:

AF004291.1 BC030600.1 BC042395.1 BC042406.1 HQ692858.1 HQ709185.1 S83309.1 U80802.1

3 DOTS entries:

DT.100698165 DT.92070028 DT.87046871

24/106 AceView cDNA sequences (see all 106):

BX116009 BQ278164 BF509290 BF373095 BU849660 BU622921 BI093487 BM728274

BM353106 BF224098 BF059563 BQ013408 AA991937 BI712988 AA563667 AI797388

BX509410 BE549861 BQ278173 AA609460 BE899143 BM977734 S83309 CK822092

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for NR6A1 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11
SP1:					-
SP2:					-		-
SP3:					-		-
SP4:

ECgene alternative splicing isoforms for NR6A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NR6A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTGTGTG

About this image

NR6A1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Somite

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

ES-J1 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Short-term differentiated embryoid bodies (Derivation of embryo...)

Long-time differentiated EBs (Derivation of embryo...)

See NR6A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR6A1

SOURCE GeneReport for Unigene cluster: Hs.586460

UniProtKB/Swiss-Prot: NR6A1_HUMAN, Q15406

Tissue specificity: Shows highest expression in the germ cells of the adult testis

SABiosciences Expression via Pathway-Focused PCR Arrays including NR6A1:

Embryonic Stem Cells in human mouse rat

Nuclear Receptors & Coregulators in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR6A1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR6A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NR6A1 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NR6A1¹	nuclear receptor subfamily 6, group A, member 1	80.9(n) 90.49(a)		772325 XM_001235477.2 XP_001235478.2
lizard (Anolis carolinensis)	Reptilia	NR6A1⁶	--	86(a)	1 ↔ 1	GL343937.1(67863-86683)
African clawed frog (Xenopus laevis)	Amphibia	Xl.377²	Xenopus laevis nuclear orphan receptor xGCNF mRNA, more	74.81(n)		U58683.1
zebrafish (Danio rerio)	Actinopterygii	nr6a1²	nuclear receptor subfamily 6, group A, member 1	76.68(n)		30506 AJ007703.1
fruit fly (Drosophila melanogaster)	Insecta	Hr4⁶	Hr4	5(a)	1 ↔ 1	X(1835973-1901989)
worm (Caenorhabditis elegans)	Secernentea	nhr-91⁶	Nuclear hormone receptor family member nhr-91	21(a)	1 ↔ 1	X(15309305-15314830)

ENSEMBL Gene Tree for NR6A1 (if available)
TreeFam Gene Tree for NR6A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NR6A1 gene

NR5A2² NR5A1²

18/21 SIMAP similar genes for NR6A1 using alignment to 4 protein entries: NR6A1_HUMAN (see all proteins) (see all similar genes):

NR2C2 BCOR-RARA RARB RORA NR3C2 PPARA

HNF4alpha NR2F1 HNF4G PPARG ESRRB ESRRG

NR4A2 THRB VDR ESR1 NR1F1 RXRB

NR6A1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148544173^1,2		--	127284302(+)	`AGGACG/TTGTTG`	2	--	ds500¹		0	--	--	--	--
rs144286846^1,2		--	127284305(+)	`ACTTGA/TTGGGT`	2	--	ds500¹		0	--	--	--	--
rs1104924^1,2	C,F,H	--	127284349(+)	`CCCTAC/TTCTCT`	2	--	ds500¹ ese³		10		MN NS EA NA	1166
rs141340739^1,2		--	127284414(+)	`GTTGCC/TGTCTC`	2	--	ds500¹		0	--	--	--	--
rs10986357^1,2	C,H	--	127284434(+)	`GCTTAG/CTGAAT`	2	--	ds500¹ ese³		4		NS EA	420
rs71495523^1,2	C,F	--	127284465(+)	`CCTTAC/TAGTGT`	2	--	ds500¹		3		NA	124
rs78876029^1,2	F	--	127284510(+)	`GCAATT/CTGCTC`	2	--	ds500¹		1		WA	118
rs116719805^1,2		--	127284530(+)	`CAAATG/CTATGA`	2	--	ds500¹		1		WA	118
rs182776978^1,2		--	127284533(+)	`ATGTAC/TGAGTC`	2	--	ds500¹		0	--	--	--	--
rs187766139^1,2		--	127284660(+)	`AAATAC/TAAAAG`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NR6A1 (127279888 - 127529888 bp, first 250kb of NR6A1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NR6A1
2 CNVs: 100780 100779

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NR6A1 for disorders           About GeneDecksing

OMIM gene information: 602778    OMIM disorders: --

16 diseases for NR6A1:    About MalaCards

nail-patella syndrome cleft lip/palate cleft lip acute promyelocytic leukemia

teratocarcinoma allergic asthma sjogren's syndrome embryonal carcinoma

asthma breast cancer carcinoma leukemia

cholesterol hypoxia thyroiditis neuronitis

1 disease from the University of Copenhagen DISEASES database for NR6A1:

Embryonal carcinoma

2 Novoseek disease relationships for NR6A1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma embryonal	49.9	4	9134503 (1), 10524192 (1), 8982251 (1)
teratocarcinoma	48.5	1	16954206 (1)

Human Genome Epidemiology (HuGE) Navigator: NR6A1 (2 documents)

Export disorders for NR6A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NR6A1 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with NR6A1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation. (PubMed id 9134503)^{1, 2, 3, 9} Lei W.... Jetten A.M. (1997)
Characterization of the human germ cell nuclear factor gene. (PubMed id 8982251)^{1, 2, 3, 9} Susens U. and Borgmeyer U. (1996)
RAP80: a novel nuclear protein that interacts with the retinoid- related testis-associated receptor. (PubMed id 12080054)^{1, 2, 9} Yan Z.... Jetten A.M. (2002)
Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF. (PubMed id 9537518)^{1, 2, 9} Agoulnik I.Y.... Cooney A.J. (1998)
cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF). (PubMed id 9177477)^{1, 2, 9} Kapelle M.... Schleuning W.-D. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of the repressor function of the nuclear orphan receptor retinoid receptor-related testis-associated receptor/germ cell nuclear factor. (PubMed id 10940306)^{1, 9} Yan Z. and Jetten A.M. (2000)
Germ cell nuclear factor: an orphan receptor with unexpected properties. (PubMed id 9846950)^{1, 9} Greschik H. and Schule R. (1998)
Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblasts. (PubMed id 11969338)^{1, 9} Mehta D.V....Jetten A.M. (2002)
Genomic structure of the gene for mouse germ-cell nuclear factor (GCNF). II. Comparison with the genomic structure of the human GCNF gene. (PubMed id 11387038)^{1, 9} Susens U. and Borgmeyer U. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2649	HGNC: 7985	AceView: NR6A1	Ensembl:ENSG00000148200	euGenes: HUgn2649
ECgene: NR6A1	H-InvDB: NR6A1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NR6A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NR6A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NR6A1 gene:
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GeneCards and IP:
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NR6A1 Gene

nuclear receptor subfamily 6, group A, member 1

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NR6A1 Gene

nuclear receptor subfamily 6, group A, member 1

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