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Aliases for NR6A1 Gene

Aliases for NR6A1 Gene

  • Nuclear Receptor Subfamily 6, Group A, Member 1 2 3
  • GCNF 3 4 6
  • Retinoid Receptor-Related Testis-Specific Receptor 3 4
  • HGCNF 3 4
  • HRTR 3 4
  • RTR 3 4
  • Retinoic Acid Receptor-Related Testis-Associated Receptor 3
  • Nuclear Receptor Subfamily 6 Group A Member 1 3
  • Germ Cell Nuclear Factor Variant 1 3
  • Germ Cell Nuclear Factor 4
  • CT150 3
  • GCNF1 3
  • NR61 3

External Ids for NR6A1 Gene

Previous Symbols for NR6A1 Gene

  • GCNF

Summaries for NR6A1 Gene

Entrez Gene Summary for NR6A1 Gene

  • This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

GeneCards Summary for NR6A1 Gene

NR6A1 (Nuclear Receptor Subfamily 6, Group A, Member 1) is a Protein Coding gene. Among its related pathways are Oct4 in Mammalian ESC Pluripotency and Wnt / Hedgehog / Notch. GO annotations related to this gene include protein homodimerization activity and steroid hormone receptor activity. An important paralog of this gene is NR5A1.

UniProtKB/Swiss-Prot for NR6A1 Gene

  • Orphan nuclear receptor. Binds to a response element containing the sequence 5-TCAAGGTCA-3. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).

Gene Wiki entry for NR6A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR6A1 Gene

Genomics for NR6A1 Gene

Genomic Location for NR6A1 Gene

Start:
124,517,275 bp from pter
End:
124,771,310 bp from pter
Size:
254,036 bases
Orientation:
Minus strand

Genomic View for NR6A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR6A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR6A1 Gene

Regulatory Elements for NR6A1 Gene

Proteins for NR6A1 Gene

  • Protein details for NR6A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15406-NR6A1_HUMAN
    Recommended name:
    Nuclear receptor subfamily 6 group A member 1
    Protein Accession:
    Q15406
    Secondary Accessions:
    • O00551
    • O00603
    • Q5T6F4
    • Q8NHQ0
    • Q92898
    • Q99802

    Protein attributes for NR6A1 Gene

    Size:
    480 amino acids
    Molecular mass:
    54383 Da
    Quaternary structure:
    • Homodimer. Interacts with UIMC1 (By similarity).

    Alternative splice isoforms for NR6A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR6A1 Gene

Proteomics data for NR6A1 Gene at MOPED

Post-translational modifications for NR6A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR6A1 Gene

No data available for DME Specific Peptides for NR6A1 Gene

Domains for NR6A1 Gene

Gene Families for NR6A1 Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

UniProtKB/Swiss-Prot:

NR6A1_HUMAN
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.:
    • Q15406
Family:
  • Belongs to the nuclear hormone receptor family. NR6 subfamily.:
    • Q15406
genes like me logo Genes that share domains with NR6A1: view

Function for NR6A1 Gene

Molecular function for NR6A1 Gene

GENATLAS Biochemistry: nuclear receptor subfamily 6,group A,member 1,steroid/thyroid receptor superfamily,potentially involved in spermatogenic maturation
UniProtKB/Swiss-Prot Function: Orphan nuclear receptor. Binds to a response element containing the sequence 5-TCAAGGTCA-3. May be involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for NR6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with NR6A1: view
genes like me logo Genes that share phenotypes with NR6A1: view

Animal Models for NR6A1 Gene

MGI Knock Outs for NR6A1:

miRNA for NR6A1 Gene

miRTarBase miRNAs that target NR6A1

Transcription Factor Targeting for NR6A1 Gene

Selected GeneGlobe predicted Target genes for NR6A1

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for NR6A1 Gene

Localization for NR6A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR6A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR6A1 Gene COMPARTMENTS Subcellular localization image for NR6A1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for NR6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex ISS --
genes like me logo Genes that share ontologies with NR6A1: view

Pathways for NR6A1 Gene

genes like me logo Genes that share pathways with NR6A1: view

Pathways by source for NR6A1 Gene

1 Qiagen pathway for NR6A1 Gene
1 Cell Signaling Technology pathway for NR6A1 Gene

Gene Ontology (GO) - Biological Process for NR6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007276 gamete generation ISS --
genes like me logo Genes that share ontologies with NR6A1: view

Compounds for NR6A1 Gene

(5) Novoseek inferred chemical compound relationships for NR6A1 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 63.4 18
retinoid 52.5 5
protamine 37.7 3
estrogen 19 1
cholesterol 0 1
genes like me logo Genes that share compounds with NR6A1: view

Transcripts for NR6A1 Gene

Unigene Clusters for NR6A1 Gene

Nuclear receptor subfamily 6, group A, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR6A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for NR6A1 Gene

GeneLoc Exon Structure for
NR6A1
ECgene alternative splicing isoforms for
NR6A1

Expression for NR6A1 Gene

mRNA expression in normal human tissues for NR6A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR6A1 Gene

This gene is overexpressed in Testis (11.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NR6A1 Gene

SOURCE GeneReport for Unigene cluster for NR6A1 Gene Hs.586460

mRNA Expression by UniProt/SwissProt for NR6A1 Gene

Q15406-NR6A1_HUMAN
Tissue specificity: Shows highest expression in the germ cells of the adult testis.
genes like me logo Genes that share expressions with NR6A1: view

Orthologs for NR6A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR6A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR6A1 36
  • 99.79 (n)
  • 99.58 (a)
NR6A1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NR6A1 36
  • 93.76 (n)
  • 97.92 (a)
NR6A1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR6A1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr6a1 36
  • 92.92 (n)
  • 98.33 (a)
Nr6a1 16
Nr6a1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR6A1 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR6A1 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr6a1 36
  • 91.53 (n)
  • 97.69 (a)
chicken
(Gallus gallus)
Aves NR6A1 36
  • 80.59 (n)
  • 90.26 (a)
NR6A1 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR6A1 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.377 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nr6a1 36
  • 75.37 (n)
  • 84.85 (a)
Str.6227 36
zebrafish
(Danio rerio)
Actinopterygii nr6a1 36
nr6a1a 36
  • 75.2 (n)
  • 81.82 (a)
nr6a1a 37
  • 77 (a)
OneToMany
nr6a1b 37
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ftz-f1 37
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhr-25 37
  • 16 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4084 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToOne
Species with no ortholog for NR6A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR6A1 Gene

ENSEMBL:
Gene Tree for NR6A1 (if available)
TreeFam:
Gene Tree for NR6A1 (if available)

Paralogs for NR6A1 Gene

Paralogs for NR6A1 Gene

Selected SIMAP similar genes for NR6A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NR6A1: view

Variants for NR6A1 Gene

Sequence variations from dbSNP and Humsavar for NR6A1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs722477 -- 124,712,315(+) AATAA(A/G)AGTCT intron-variant
rs915030 -- 124,525,699(+) TCTCT(A/C)TATAT intron-variant
rs915031 -- 124,527,523(+) ctttg(A/T)gagca intron-variant
rs1055611 -- 124,653,539(-) TAGTT(A/G)CTTGT intron-variant
rs1104924 -- 124,522,070(+) CCCTA(C/T)TCTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NR6A1 Gene

Variant ID Type Subtype PubMed ID
nsv466558 CNV Loss 19166990
nsv466559 CNV Loss 19166990
nsv526209 CNV Gain 19592680
nsv6712 CNV Loss 18451855
esv2669194 CNV Deletion 23128226
nsv893837 CNV Gain 21882294
nsv6713 CNV Insertion 18451855
nsv831721 CNV Gain 17160897
esv2457492 CNV Deletion 19546169
esv2482264 CNV Deletion 19546169

Relevant External Links for NR6A1 Gene

HapMap Linkage Disequilibrium report
NR6A1

Disorders for NR6A1 Gene

(1) University of Copenhagen DISEASES for NR6A1 Gene

(2) Novoseek inferred disease relationships for NR6A1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma embryonal 49.9 3
teratocarcinoma 48.5 1

Relevant External Links for NR6A1

Genetic Association Database (GAD)
NR6A1
Human Genome Epidemiology (HuGE) Navigator
NR6A1
genes like me logo Genes that share disorders with NR6A1: view

No data available for UniProtKB/Swiss-Prot for NR6A1 Gene

Publications for NR6A1 Gene

  1. Characterization of the human germ cell nuclear factor gene. (PMID: 8982251) Suesens U. … Borgmeyer U. (Biochim. Biophys. Acta 1996) 2 3 4 23
  2. Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation. (PMID: 9134503) Lei W. … Jetten A.M. (J. Mol. Endocrinol. 1997) 2 3 4 23
  3. cDNA cloning of two closely related forms of human germ cell nuclear factor (GCNF). (PMID: 9177477) Kapelle M. … Schleuning W.-D. (Biochim. Biophys. Acta 1997) 3 4 23
  4. Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF. (PMID: 9537518) Agoulnik I.Y. … Cooney A.J. (FEBS Lett. 1998) 3 4 23
  5. RAP80: a novel nuclear protein that interacts with the retinoid- related testis-associated receptor. (PMID: 12080054) Yan Z. … Jetten A.M. (J. Biol. Chem. 2002) 3 4 23

Products for NR6A1 Gene

Sources for NR6A1 Gene

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