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Aliases for NR4A3 Gene

Aliases for NR4A3 Gene

  • Nuclear Receptor Subfamily 4, Group A, Member 3 2 3
  • CSMF 3 4 6
  • Mitogen-Induced Nuclear Orphan Receptor 3 4
  • Neuron-Derived Orphan Receptor 1 3 4
  • Nuclear Hormone Receptor NOR-1 3 4
  • MINOR 3 4
  • NOR1 3 4
  • TEC 3 4
  • CHN 3 4
  • Chondrosarcoma, Extraskeletal Myxoid, Fused To EWS 3
  • Nuclear Receptor Subfamily 4 Group A Member 3 3
  • Translocated In Extraskeletal Chondrosarcoma 3

External Ids for NR4A3 Gene

Summaries for NR4A3 Gene

Entrez Gene Summary for NR4A3 Gene

  • This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for NR4A3 Gene

NR4A3 (Nuclear Receptor Subfamily 4, Group A, Member 3) is a Protein Coding gene. Diseases associated with NR4A3 include chondrosarcoma, extraskeletal myxoid and chondrosarcoma. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include sequence-specific DNA binding and steroid hormone receptor activity. An important paralog of this gene is AR.

UniProtKB/Swiss-Prot for NR4A3 Gene

  • Binds to the B1A response-element

Gene Wiki entry for NR4A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR4A3 Gene

Genomics for NR4A3 Gene

Genomic Location for NR4A3 Gene

Start:
99,821,855 bp from pter
End:
99,866,891 bp from pter
Size:
45,037 bases
Orientation:
Plus strand

Genomic View for NR4A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR4A3 Gene

Regulatory Elements for NR4A3 Gene

Transcription factor binding sites by QIAGEN in the NR4A3 gene promoter:

Proteins for NR4A3 Gene

  • Protein details for NR4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92570-NR4A3_HUMAN
    Recommended name:
    Nuclear receptor subfamily 4 group A member 3
    Protein Accession:
    Q92570
    Secondary Accessions:
    • A2A3I7
    • Q12935
    • Q14979
    • Q16420
    • Q4VXA8
    • Q4VXA9
    • Q9UEK2
    • Q9UEK3

    Protein attributes for NR4A3 Gene

    Size:
    626 amino acids
    Molecular mass:
    68230 Da
    Quaternary structure:
    • Interacts with SIX3(via homeobox); differentially regulates the transcriptional activities NR4A3.
    SequenceCaution:
    • Sequence=AAB02581.1; Type=Frameshift; Positions=4, 20; Evidence={ECO:0000305}; Sequence=AAB36006.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NR4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR4A3 Gene

Proteomics data for NR4A3 Gene at MOPED

Post-translational modifications for NR4A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR4A3 Gene

No data available for DME Specific Peptides for NR4A3 Gene

Domains for NR4A3 Gene

Gene Families for NR4A3 Gene

UniProtKB/Swiss-Prot:

NR4A3_HUMAN
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.:
    • Q92570
Family:
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.:
    • Q92570
genes like me logo Genes that share domains with NR4A3: view

Function for NR4A3 Gene

Molecular function for NR4A3 Gene

GENATLAS Biochemistry: nuclear receptor subfamily 4,group A,member 3, the steroid/thyroid receptor superfamily,with variants generated by alternative splicing,involved in extraskeletal and skeletal myxoid chondrosarcoma EMC with translocation t(9;22)(q22;q12) see EWS,EWSR,and in neural development processes
UniProtKB/Swiss-Prot Function: Binds to the B1A response-element

Gene Ontology (GO) - Molecular Function for NR4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding NAS 8634690
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003707 steroid hormone receptor activity IEA --
GO:0004887 thyroid hormone receptor activity TAS 8570200
genes like me logo Genes that share ontologies with NR4A3: view
genes like me logo Genes that share phenotypes with NR4A3: view

Animal Models for NR4A3 Gene

MGI Knock Outs for NR4A3:

miRNA for NR4A3 Gene

miRTarBase miRNAs that target NR4A3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NR4A3 Gene

Localization for NR4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR4A3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR4A3 Gene COMPARTMENTS Subcellular localization image for NR4A3 gene
Compartment Confidence
nucleus 4
cytosol 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NR4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8634690
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with NR4A3: view

Pathways for NR4A3 Gene

genes like me logo Genes that share pathways with NR4A3: view

Gene Ontology (GO) - Biological Process for NR4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007411 axon guidance IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NR4A3: view

Compounds for NR4A3 Gene

(3) Novoseek inferred chemical compound relationships for NR4A3 Gene

Compound -log(P) Hits PubMed IDs
nor 1 96.7 27
tyrosine 19.8 5
steroid 14.5 4
genes like me logo Genes that share compounds with NR4A3: view

Transcripts for NR4A3 Gene

Unigene Clusters for NR4A3 Gene

Nuclear receptor subfamily 4, group A, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR4A3 Gene

No ASD Table

Relevant External Links for NR4A3 Gene

GeneLoc Exon Structure for
NR4A3
ECgene alternative splicing isoforms for
NR4A3

Expression for NR4A3 Gene

mRNA expression in normal human tissues for NR4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR4A3 Gene

This gene is overexpressed in Heart - Atrial Appendage (6.1), Muscle - Skeletal (4.8), Artery - Tibial (4.7), and Adipose - Visceral (Omentum) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NR4A3 Gene

SOURCE GeneReport for Unigene cluster for NR4A3 Gene Hs.279522

mRNA Expression by UniProt/SwissProt for NR4A3 Gene

Q92570-NR4A3_HUMAN
Tissue specificity: Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta
genes like me logo Genes that share expressions with NR4A3: view

Orthologs for NR4A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR4A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR4A3 36
  • 99.37 (n)
  • 99.53 (a)
NR4A3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NR4A3 36
  • 92.31 (n)
  • 93.56 (a)
NR4A3 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR4A3 36
  • 91.37 (n)
  • 91.85 (a)
mouse
(Mus musculus)
Mammalia Nr4a3 36
  • 88.96 (n)
  • 92.77 (a)
Nr4a3 16
Nr4a3 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR4A3 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR4A3 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr4a3 36
  • 88.66 (n)
  • 92.94 (a)
chicken
(Gallus gallus)
Aves NR4A3 36
  • 79.34 (n)
  • 81.49 (a)
NR4A3 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR4A3 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr4a3 36
  • 62.02 (n)
  • 61.62 (a)
Str.5118 36
zebrafish
(Danio rerio)
Actinopterygii nr4a3 36
  • 60.78 (n)
  • 60.84 (a)
nr4a3 37
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hr38 37
  • 27 (a)
OneToMany
Hr38 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea nhr-6 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToMany
Species with no ortholog for NR4A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR4A3 Gene

ENSEMBL:
Gene Tree for NR4A3 (if available)
TreeFam:
Gene Tree for NR4A3 (if available)

Paralogs for NR4A3 Gene

Paralogs for NR4A3 Gene

Selected SIMAP similar genes for NR4A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NR4A3: view

Variants for NR4A3 Gene

Sequence variations from dbSNP and Humsavar for NR4A3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1405209 -- 99,823,263(-) GTCTC(A/G)CCACC intron-variant
rs1526267 -- 99,827,463(-) ACCTC(A/G)TCCCC intron-variant
rs1918008 -- 99,824,109(-) GCTCC(G/T)GCTTG intron-variant
rs1918009 -- 99,823,766(-) CCAGG(C/G)AAAGG intron-variant
rs2416879 -- 99,851,390(-) AATGT(A/G)AATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NR4A3 Gene

Variant ID Type Subtype PubMed ID
nsv893621 CNV Gain 21882294
nsv528025 CNV Gain 19592680
nsv893622 CNV Loss 21882294
nsv831668 CNV Gain+Loss 17160897
esv1004519 CNV Insertion 20482838

Relevant External Links for NR4A3 Gene

HapMap Linkage Disequilibrium report
NR4A3

Disorders for NR4A3 Gene

(1) OMIM Diseases for NR4A3 Gene (600542)

UniProtKB/Swiss-Prot

NR4A3_HUMAN
  • Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.
  • Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.

(1) University of Copenhagen DISEASES for NR4A3 Gene

(4) Novoseek inferred disease relationships for NR4A3 Gene

Disease -log(P) Hits PubMed IDs
chondrosarcoma 82.2 11
sarcoma 31.8 1
tumors 0 2
cancer 0 1

Relevant External Links for NR4A3

Genetic Association Database (GAD)
NR4A3
Human Genome Epidemiology (HuGE) Navigator
NR4A3
genes like me logo Genes that share disorders with NR4A3: view

Publications for NR4A3 Gene

  1. The isolation and characterization of MINOR, a novel mitogen- inducible nuclear orphan receptor. (PMID: 8614405) Hedvat C.V. … Irving S.G. (Mol. Endocrinol. 1995) 2 3 4 23
  2. Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. (PMID: 8634690) Labelle Y. … Thomas G. (Hum. Mol. Genet. 1995) 3 4 23
  3. Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. (PMID: 8570200) Clark J. … Cooper C.S. (Oncogene 1996) 3 4 23
  4. Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA. (PMID: 9573341) Ohkura N. … Miki K. (Gene 1998) 3 4 23
  5. The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas. (PMID: 12543801) Laflamme C. … Labelle Y. (Cancer Res. 2003) 3 4 23

Products for NR4A3 Gene

Sources for NR4A3 Gene

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