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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NR4A3 Gene

protein-coding GIFtS: 57
GCID: GC09P102584

nuclear receptor subfamily 4, group A, member 3

Explore 21 diseases affiliated with
NR4A3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 4, Group A, Member 3¹ ²		Neuron-Derived Orphan Receptor 1² ³
CSMF¹ ² ³ ⁵		Nuclear Hormone Receptor NOR-1² ³
CHN¹ ² ³		TEC² ³
MINOR¹ ² ³		Chondrosarcoma, Extraskeletal Myxoid, Fused To EWS²
NOR1¹ ² ³		Nuclear Receptor Subfamily 4 Group A Member 3²
Mitogen-Induced Nuclear Orphan Receptor² ³		Translocated In Extraskeletal Chondrosarcoma²

External Ids:	HGNC: 7982¹	Entrez Gene: 8013²	Ensembl: ENSG00000119508⁷	OMIM: 600542⁵	UniProtKB: Q92570³

Export aliases for NR4A3 gene to outside databases

Previous GC identifers: GC09P093384 GC09P094327 GC09P096041 GC09P097963 GC09P099663 GC09P101623 GC09P072183

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR4A3:

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as

a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different

versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene

and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on

chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding

Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple

transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: NR4A3_HUMAN, Q92570

Function: Binds to the B1A response-element

Gene Wiki entry for NR4A3 (Neuron-derived orphan receptor 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NR4A3 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NR4A3 promoter sequence

Search SABiosciences Chromatin IP Primers for NR4A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR4A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q22

NR4A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR4A3 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P102584: view genomic region (about GC identifiers)

Start:	102,584,137 bp from pter	End:	102,629,173 bp from pter
Size:	45,037 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NR4A3_HUMAN, Q92570 (See protein sequence)

Recommended Name: Nuclear receptor subfamily 4 group A member 3

Size: 626 amino acids; 68230 Da

Subcellular location: Nucleus (Potential)

Sequence caution: Sequence=AAB02581.1; Type=Frameshift; Positions=4, 20; Sequence=AAB36006.1; Type=Erroneous

initiation;

Secondary accessions: A2A3I7 Q12935 Q14979 Q16420 Q4VXA8 Q4VXA9 Q9UEK2 Q9UEK3

Alternative splicing: 3 isoforms: Q92570-1 Q92570-2 Q92570-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NR4A3: NX_Q92570

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92570

NR4A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_008912.2 NP_775291.1 NP_775292.1

ENSEMBL proteins:

ENSP00000378531 ENSP00000340301 ENSP00000333122

Reactome Protein details: Q92570
Human Recombinant Protein Products for NR4A3:

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	Uscn Proteins for NR4A3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	8634690
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IEA	--

NR4A3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NR4A3 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR013088 Znf_NHR/GATA

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

IPR001628 Znf_hrmn_rcpt

IPR001723 Str_hrmn_rcpt

Graphical View of Domain Structure for InterPro Entry Q92570

ProtoNet protein and cluster: Q92570

3 Blocks protein families:

IPB001723 Steroid hormone receptor signature

IPB003070 Orphan nuclear receptor (4A nuclear receptor) family signature

IPB003072 Orphan nuclear receptor NOR1 signature

UniProtKB/Swiss-Prot: NR4A3_HUMAN, Q92570

Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NR4A3_HUMAN, Q92570

Function: Binds to the B1A response-element

Genatlas biochemistry entry for NR4A3:

nuclear receptor subfamily 4,group A,member 3, the steroid/thyroid receptor superfamily,with variants generated by

alternative splicing,involved in extraskeletal and skeletal myxoid chondrosarcoma EMC with translocation

t(9;22)(q22;q12) see EWS,EWSR,and in neural development processes

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0003677	DNA binding	NAS	8634690
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0004887	thyroid hormone receptor activity	TAS	8570200
GO:0005488	binding	--	--

NR4A3 for ontologies About GeneDecksing

Phenotypes:
13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nr4a3):

behavior/neurological	cellular	embryogenesis	growth/size	hearing/vestibular/ear
hematopoietic system	homeostasis/metabolism	immune system	integument	liver/biliary system
mortality/aging	nervous system	tumorigenesis

NR4A3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for NR4A3: Nr4a3^tm1Dgen Nr4a3^tm1Wnt

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NR4A3

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		hsa-miR-411* hsa-miR-579 hsa-miR-520e hsa-miR-106a hsa-miR-374a hsa-miR-4325 hsa-miR-93 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: NR4A3 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR4A3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Nuclear Receptor transcription pathway

Nuclear Receptor transcription pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for NR4A3

	Generic Transcription Pathway
	Nuclear Receptor transcription pathway
	Gene Expression

NR4A3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NR4A3

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/9 Interacting proteins for NR4A3 (Q92570³ ENSP00000333122⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIX3	O95343³, ENSP00000260653⁴	I2D: score=3 STRING: ENSP00000260653
TRIM28	Q13263³, ENSP00000253024⁴	I2D: score=1 STRING: ENSP00000253024
VHL	P40337³, ENSP00000256474⁴	I2D: score=1 STRING: ENSP00000256474
RPS6KA1	Q15418³, ENSP00000363277⁴	I2D: score=2 STRING: ENSP00000363277
KDM5B	Q9UGL1³, ENSP00000356234⁴	I2D: score=1 STRING: ENSP00000356234

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001707	mesoderm formation	IEA	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0007411	axon guidance	IEA	--
GO:0008150	biological_process	ND	--
GO:0010467	gene expression	TAS	--

NR4A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NR4A3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NR4A3
3 Novoseek chemical compound relationships for NR4A3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nor 1	96.7	40	16945922 (8), 10773199 (4), 15262426 (3), 14525795 (2) (see all 14)
tyrosine	19.8	5	10523612 (2), 17785466 (1), 15788485 (1), 11358387 (1)
steroid	14.5	4	8570200 (2), 16493583 (1), 11487030 (1)

Search CenterWatch for drugs/clinical trials and news about NR4A3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NR4A3 gene (4 alternative transcripts):

NM_006981.3 NM_173199.2 NM_173200.2 NM_173198.1

Unigene Cluster for NR4A3:

Nuclear receptor subfamily 4, group A, member 3

Hs.279522 [show with all ESTs]

Unigene Representative Sequence: NM_173200

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000395097 ENST00000338488(uc004bae.3) ENST00000330847(uc022bky.1 uc004baf.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): NR4A3 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-411* hsa-miR-579 hsa-miR-520e hsa-miR-106a hsa-miR-374a hsa-miR-4325 hsa-miR-93 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: NR4A3 3' UTR sequence

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Additional cDNA sequence:

AK027388.1 AK226108.1 BX649089.1 D78579.1 D85241.1 D85242.1 S81242.1 S81243.1

X89894.1

8 DOTS entries:

DT.100748418 DT.413728 DT.91836856 DT.95237739 DT.92041977 DT.91706558 DT.91741844 DT.97762046

24/72 AceView cDNA sequences (see all 72):

BQ006220 X89894 NM_173200 CA447139 AA421939 NM_173198 CA445850 BQ431513

CA440796 AA648528 AW612177 NM_173199 AI559323 BM992796 NM_006981 BM674223

BQ716917 BM557376 AI911092 BF968628 AL710005 CD641001 BM549822 AI954046

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NR4A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTCTGTGG

About this image

NR4A3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NR4A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR4A3

SOURCE GeneReport for Unigene cluster: Hs.279522

UniProtKB/Swiss-Prot: NR4A3_HUMAN, Q92570

Tissue specificity: Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal

muscle and low expressed in fetal brain and placenta

SABiosciences Expression via Pathway-Focused PCR Arrays including NR4A3:

Leukemia in human mouse rat

T Helper Cell Differentiation in human mouse rat

Tumor Metastasis in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NR4A3 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NR4A3¹	nuclear receptor subfamily 4, group A, member 3	81.04(n) 83.87(a)		420996 XM_419081.3 XP_419081.3
lizard (Anolis carolinensis)	Reptilia	NR4A3⁶	--	76(a)	1 ↔ 1	6(55236361-55260741)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.5118²	Transcribed sequence with weak similarity to protein more	78.38(n)		BQ393571.1
zebrafish (Danio rerio)	Actinopterygii	nr4a3¹	nuclear receptor subfamily 4, group A, member 3	61.54(n) 62.59(a)		548604 NM_001172629.1 NP_001166100.1
fruit fly (Drosophila melanogaster)	Insecta	Hr38³	epidermal differentiation ligand-dependent nuclear more	62(a)		--
worm (Caenorhabditis elegans)	Secernentea	nhr-6⁶	Nuclear hormone receptor family member nhr-6	17(a)	1 → many	III(3573572-3578759)

ENSEMBL Gene Tree for NR4A3 (if available)
TreeFam Gene Tree for NR4A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NR4A3 gene

VDR² NR4A1² NR1I2² RARG² NR1I3² THRB² RARA² NR4A2²

NR1H4² NR1H2² RARB² THRA² NR1H3²

4 SIMAP similar genes for NR4A3 using alignment to 1 protein entry: NR4A3_HUMAN:

NR4A2 DKFZp451G125 NR4A1 NR1B2

NR4A3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7467433^1,2	C,F,A	--	72181410(+)	`CGGCGG/AGGTCA`	3	--	us2k¹		1	NA	120
rs12353385^1,2	H	--	72181670(+)	`ATCGCC/TTGCGT`	3	--	us2k¹		4	NS EA	418
rs75335538^1,2		--	72182182(+)	`GACTGC/TGTTCA`	3	--	us2k¹		1	EA	120
rs73499661^1,2	C	--	72182684(+)	`TCCCCG/AGAACC`	3	--	us2k¹		2	WA	120
rs1856928^1,2	C,F,H	--	72182847(+)	`GACGCC/ATTCTG`	3	--	us2k¹ tfbs³		5	EA NS NA	260
rs1918008^1,2	C,F,H	--	72185593(-)	`GCTCCT/GGCTTG`	3	--	int¹		22	NA NS EA CSA WA	2456
rs111462594^1,2		--	72186069(+)	`CCCTTC/TCTCTC`	3	--	int¹		1	CSA	2
rs74338546^1,2	C,F	--	72186874(+)	`TTTTTT/AAGCCT`	3	--	int¹		1	EA	120
rs2293403^1,2	C,F,H	--	72187129(-)	`AAGGTA/G/TAAAGA`	3	--	int¹		8	NS EA NA	754
rs111594427^1,2	F	--	72187935(+)	`TAGAAT/ACCTCA`	3	--	int¹		1	CSA	4

HapMap Linkage Disequilibrium report for NR4A3 (102584137 - 102629173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NR4A3
1 CNV: 4649

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NR4A3 for disorders           About GeneDecksing

OMIM gene information: 600542
OMIM disorders: 612237
UniProtKB/Swiss-Prot: NR4A3_HUMAN, Q92570

Defects in NR4A3 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive

small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma

family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They

are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated

form of the tumors. Note=A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma.

Translocation t(9;22)(q22-31;q11-12) with EWSR1

Note=A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas

(EMC). Translocation t(9;17)(q22;q11) with TAF2N

20/21 diseases for NR4A3 (see all 21): About MalaCards

extraskeletal myxoid chondrosarcoma chondrosarcoma myxoid chondrosarcoma maturity-onset diabetes of the young

thyroiditis neuronitis fetal adenoma acute myeloid leukemia

myeloid leukemia insulin resistance holoprosencephaly bipolar disorder

conjunctivitis adenoma hematopoiesis gingivitis

nasopharyngitis leukemia atherosclerosis hypoxia

1 disease from the University of Copenhagen DISEASES database for NR4A3:

Chondrosarcoma

4 Novoseek disease relationships for NR4A3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
chondrosarcoma	82.2	18	10537274 (2), 11156374 (2), 8570200 (2), 10410173 (1) (see all 8)
sarcoma	31.8	1	9781944 (1)
tumors	0	3	12378528 (2)
cancer	0	2	17302560 (1)

Human Genome Epidemiology (HuGE) Navigator: NR4A3 (3 documents)

Export disorders for NR4A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NR4A3 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with NR4A3)

Utopia: connect your pdf to the dynamic
world of online information

The isolation and characterization of MINOR, a novel mitogen- inducible nuclear orphan receptor. (PubMed id 8614405)^{1, 2, 3, 9} Hedvat C.V. and Irving S.G. (1995)
Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. (PubMed id 8570200)^{1, 2, 9} Clark J.... Cooper C.S. (1996)
Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation. (PubMed id 8634690)^{1, 2, 9} Labelle Y.... Thomas G. (1995)
Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA. (PubMed id 9573341)^{1, 2, 9} Ohkura N.... Miki K. (1998)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family. (PubMed id 8809112)^{1, 2} Ohkura N.... Miki K. (1996)
The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. (PubMed id 16945922)^{1, 9} Nomiyama T....Bruemmer D. (2006)
Fluorescence in situ hybridization analysis of extras keletal myxoid chondrosarcomas using EWSR1 and NR4A3 probes. (PubMed id 19775727)^{1, 9} Noguchi H....Hasegawa T. (2010)
Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). (PubMed id 11156374)^{1, 9} Sjogren H....Kindblom J.M. (2000)
Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). (PubMed id 10602519)^{1, 9} Panagopoulos I.... Heim S. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8013	HGNC: 7982	AceView: NR4A3	Ensembl:ENSG00000119508	euGenes: HUgn8013
ECgene: NR4A3	H-InvDB: NR4A3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NR4A3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NR4A3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NR4A3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NR4A3 gene:
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GeneCards and IP:
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nuclear receptor subfamily 4, group A, member 3

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nuclear receptor subfamily 4, group A, member 3

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