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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR4A2 Gene

protein-coding   GIFtS: 67
GCID: GC02M157180

nuclear receptor subfamily 4, group A, member 2


(Previous symbol: NURR1)
 Explore 36 diseases affiliated with
NR4A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NR4A2    

Aliases
for NR4A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Receptor Subfamily 4, Group A, Member 21 2     Intermediate-Early Receptor Protein2
NOT1 2 3 5     NGFI-B/Nur77 Beta-Type Transcription Factor Homolog2
NURR11 2 3 5     Nuclear Receptor Related 12
TINUR1 2 3 5     Nuclear Receptor Subfamily 4 Group A Member 22
HZF-31 2     Nur Related Protein-1, Human Homolog Of2
RNR11 2     Orphan Nuclear Receptor NR4A22
Immediate-Early Response Protein NOT2 3     T-Cell Nuclear Receptor NOT2
Orphan Nuclear Receptor NURR12 3     Transcriptionally Inducible Nuclear Receptor Related 12
Transcriptionally-Inducible Nuclear Receptor2 3     

External Ids:    HGNC: 79811   Entrez Gene: 49292   Ensembl: ENSG000001532347   OMIM: 6018285   UniProtKB: P433543   

Export aliases for NR4A2 gene to outside databases

Previous GC identifers: GC02M155112 GC02M155709 GC02M157144 GC02M157383 GC02M157006 GC02M156889 GC02M149066


Summaries
for NR4A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NR4A2:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as
a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic
dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be
associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their
biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic
dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3,
SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)

Gene Wiki entry for NR4A2 (Nuclear receptor related 1 protein)


Genomic Views
for NR4A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR4A2 gene promoter:
         ATF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR4A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR4A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR4A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22-q23   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q22-q23

NR4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR4A2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M157180:  view genomic region     (about GC identifiers)

Start:
 157,180,944 bp from pter      End:
 157,198,860 bp from pter
Size:
 17,917 bases      Orientation:
 minus strand

Proteins
for NR4A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 4 group A member 2  
Size: 598 amino acids; 66591 Da
Subunit: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3 (By
similarity)
Subcellular location: Nucleus
Developmental stage: Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of
the cell cycle
1 PDB 3D structure from and Proteopedia for NR4A2:
1OVL (3D)    
Secondary accessions: Q16311 Q53RZ2

Explore the universe of human proteins at neXtProt for NR4A2: NX_P43354

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43354

    • NR4A2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006177.1  
    ENSEMBL proteins: 
     ENSP00000344479   ENSP00000389986   ENSP00000386747   ENSP00000415632   ENSP00000394671  
     ENSP00000386993   ENSP00000410952   ENSP00000385379   ENSP00000406808   ENSP00000388120  
     ENSP00000444925  
    Reactome Protein details: P43354
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NR4A2
    OriGene Protein Over-expression Lysate: NR4A2
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    Novus Biologicals NR4A2 Protein
    Novus Biologicals NR4A2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NR4A2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17184956
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--


    NR4A2 for ontologies           About GeneDecksing



    NR4A2 Antibody Products: 
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    ThermoFisher Antibodies for NR4A2

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    Uscn ELISAs and CLIAs for NR4A2

    Protein Domains /
    Families
    for NR4A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NR4A2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003073 NURR_rcpt
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P43354

    ProtoNet protein and cluster: P43354

    3 Blocks protein families:
    IPB001723 Steroid hormone receptor signature
    IPB003070 Orphan nuclear receptor (4A nuclear receptor) family signature
    IPB003073 Orphan nuclear receptor NURR signature


    UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
    Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Function
    for NR4A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
    Function: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic
    dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3,
    SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)

         Genatlas biochemistry entry for NR4A2:
    nuclear receptor subfamily 4,group A,member 2,steroid/thyroid receptor superfamily,rapidly and transiently expressed
    after cell activation,exclusively in the brain,likely functioning as a general coactivation of gene
    transcription,NGF1-B/nur 77

    miRNA
    Products:            		miRTarBase miRNAs that target NR4A2:
    hsa-mir-372 (MIRT003538), hsa-mir-19a (MIRT003536), hsa-mir-217 (MIRT003535), hsa-mir-302d (MIRT003537)

    OriGene 3'-UTR Clone: NR4A2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NR4A2
    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate NR4A2 (see all 90):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-1224-3p hsa-miR-30d hsa-miR-374a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: NR4A2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR4A2 (see all 7)
    OriGene shRNA RFP: NR4A2
    OriGene siRNA: NR4A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR4A2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NR4A2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR4A2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR4A2 (see all 2)
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    GenScript: all cDNA clones in your preferred vector: NR4A2 (NM_006186)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR4A2 

    Cell Line
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    Search LifeMap BioReagents cell lines for NR4A2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR4A2

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    NR4A2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for NR4A2:
     G0/1 arrest  Increased G1 DNA content  Increased cell number in G2M,   Increased cell size 

    Animal Models:
         Mouse knock-outs for NR4A2: Nr4a2tm1Omc Nr4a2tm1Tpe Nr4a2tm1Niko
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Nr4a2):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  mortality/aging 
     nervous system 

    NR4A2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NR4A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    2Nuclear Receptor transcription pathway
    		Nuclear Receptor transcription pathway1.00
    		Nuclear Receptors0.68
    3Selected targets of CREB1
    		Selected targets of CREB11.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NR4A2
        Selected targets of CREB1


    1 BioSystems Pathway for NR4A2 
        Nuclear Receptors

    3        Reactome Pathways for NR4A2
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression



    NR4A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR4A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for NR4A2 (P433541, 3 ENSP000003444794) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEAL5Q5H9L21, 3EBI-2681738,EBI-2681773 I2D: score=1 
    RXRBP287023, ENSP000003638124I2D: score=2 STRING: ENSP00000363812
    PIAS4Q8N2W93, ENSP000002629714I2D: score=1 STRING: ENSP00000262971
    RARAP102763, ENSP000002540664I2D: score=1 STRING: ENSP00000254066
    RUNX1Q011963, ENSP000003003054I2D: score=1 STRING: ENSP00000300305
    About this table

    Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001764neuron migration IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006351transcription, DNA-dependent IDA17184956
    GO:0006355regulation of transcription, DNA-dependent ----


    NR4A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NR4A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NR4A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR4A2
    10/21 Novoseek chemical compound relationships for NR4A2 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nor 1 91.4 17 14525795 (2), 18945812 (2), 12351928 (2), 12770726 (1) (see all 13)
    dopamine 69.8 104 20049900 (7), 12915123 (7), 19522012 (5), 15340833 (4) (see all 39)
    tyrosine 56.4 28 17184956 (2), 12496759 (1), 14659823 (1), 17890097 (1) (see all 24)
    retinoic acid 42.2 7 9636132 (1), 12130634 (1), 11602619 (1), 20195526 (1) (see all 6)
    retinoid 38.7 8 7705655 (1), 9636132 (1), 12122012 (1), 15635645 (1)
    forskolin 35.1 5 15106839 (3), 9931442 (1)
    steroid 33 8 7706727 (1), 10601324 (1), 10216261 (1), 11803525 (1) (see all 7)
    pd 98,059 26.4 4 15106839 (1), 17890097 (1)
    3beta-hydroxysteroid 24.2 1 15666793 (1)
    6 mercaptopurine 22.5 7 12709433 (3)

    Search CenterWatch for drugs/clinical trials and news about NR4A2 

    Transcripts
    for NR4A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NR4A2 gene (4 alternative transcripts): 
    NM_006186.3  NM_173171.1  NM_173172.1  NM_173173.1  

    Unigene Cluster for NR4A2:

    Nuclear receptor subfamily 4, group A, member 2
    Hs.563344  [show with all ESTs]
    Unigene Representative Sequence: NM_006186
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339562(uc021vri.1 uc002tyz.4 uc002tyx.4 uc010zcf.2)
    ENST00000426264 ENST00000409572 ENST00000417764(uc010zcg.1) ENST00000417972
    ENST00000409108 ENST00000429376 ENST00000406048 ENST00000424077 ENST00000421709
    ENST00000539077

    miRNA
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    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate NR4A2 (see all 90):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-1224-3p hsa-miR-30d hsa-miR-374a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: NR4A2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR4A2 (see all 7)
    OriGene shRNA RFP: NR4A2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK223625.1 AK291456.1 AK299439.1 AK309786.1 BC009288.2 BC066890.1 FJ643484.1 FJ643485.1 
    HQ692824.1 HQ709176.1 S77154.1 X75918.1 

    13 DOTS entries:

    DT.415336  DT.95375793  DT.100026308  DT.95351510  DT.40280240  DT.120951451  DT.415337  DT.86997413 
    DT.100026305  DT.120951440  DT.120951461  DT.91760528  DT.95375796 

    24/126 AceView cDNA sequences (see all 126):

    BE645908 BC066890 AI863315 NM_173173 BE047656 AA481687 AW044464 CD723871 
    AW170067 AW469461 AW337359 AA235472 AA481451 F06564 NM_006186 AW450714 
    AI978937 AA461422 AA454469 CD722676 BQ718404 CA393074 CB850547 CD245602 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NR4A2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:              -     -                                                                                                   
    SP2:              -     -           -     -                                                                                 
    SP3:                                                                                                        -               
    SP4:              -     -           -                                                                                       
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for NR4A2

    Expression
    for NR4A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR4A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATGAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NR4A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainSubstantia Nigra pars CompactaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainSubstantia Nigra pars CompactaDopaminergic Progenitor CellsDopaminergic neurons
    BrainSubstantia Nigra pars CompactaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaDopaminergic Progenitor CellsDopaminergic neurons
    BrainVentral Tegmental AreaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    EyeInner Nuclear LayerEarly Immature Amacrine CellsAmacrine, Retina
    OvaryAntral FollicleMature Granulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Midbrain dopaminergic-like neurons (Derivation of functi...)
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    Ventral/hypothalamic-like neurons (Generation of midbra...)
    Dorsal forebrain-like neurons (Generation of midbra...)Brain
    Alveolar type II cells (Derivation of mature...)Lung

    See NR4A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR4A2

    SOURCE GeneReport for Unigene cluster: Hs.563344

    UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
    Tissue specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in
    brain tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including NR4A2: 
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              Notch Signaling Pathway in human mouse rat

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    Orthologs
    for NR4A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NR4A2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NR4A21 nuclear receptor subfamily 4, group A, member 2 87.18(n)
    94.82(a)    		   424320  XM_422166.3  XP_422166.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NR4A26
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343254.1(1066893-1080938)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.128032 Transcribed sequence with weak similarity to protein more 77.16(n)    57095867 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hr383 epidermal differentiation ligand-dependent
    nuclear more    		 68(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea nhr-63 Zinc finger, C4 type (two domains) \;
    Ligand-binding more    		 35(a)   III(3645511-3650202)   --


    ENSEMBL Gene Tree for NR4A2 (if available)
    TreeFam Gene Tree for NR4A2 (if available) 

    Paralogs
    for NR4A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR4A2 gene
    VDR2  NR4A32  NR4A12  NR1I22  RARG2  NR1I32  THRB2  RARA2  
    NR1H42  NR1H22  RARB2  THRA2  NR1H32  
    18/41 SIMAP similar genes for NR4A2 using alignment to 13 protein entries:     NR4A2_HUMAN (see all proteins) (see all similar genes):
    DKFZp779O0162    NR5A2    HNF4G    RORA    NR5A1    NR6A1
    ESR1    HNF4alpha    DKFZp451G125    THRB    NR4A3    NR1I3
    NR4A1    VDR    BCOR-RARA    NR3C2    RORC    NR2C2

    NR4A2 for paralogs           About GeneDecksing



    Genomic Variants
    for NR4A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 NCBI SNPs in NR4A2 are shown (see all 163)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs782906311,2
    		C,--149067775(+) CTCTGA/CAGAAA 1 -- int10--------
    rs768807101,2
    		--149068181(+) ATAAAA/TGAGGG 1 -- int10--------
    rs1137434891,2
    		--149068294(+) CCATTG/CCATTC 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs26954441,2
    		C--149068407(+) accctC/Atggtt 1 -- int11Minor allele frequency- A:0.00NA 2
    rs178385311,2
    		C,F--149068761(-) AGAAAC/TGGGGT 1 -- int12Minor allele frequency- T:0.02EU CSA 127
    rs744722861,2
    		F,--149068892(+) AAATTG/TCCATT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs168402471,2
    		C,F,--149068938(+) GGAAAC/TGTTCA 1 -- int16Minor allele frequency- T:0.05NA WA 260
    rs575456601,2
    		C,--149069313(+) TCATGG/ATAGAG 1 -- int12Minor allele frequency- A:0.11WA 120
    rs168402511,2
    		C,F,--149070058(-) AGTATG/AGCCTC 1 -- int11Minor allele frequency- A:0.01EU 182
    rs1132769901,2
    		--149070070(+) AGGGGG/TAGTCG 1 -- int12Minor allele frequency- T:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for NR4A2 (157180944 - 157198860 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NR4A2: --
    Human Gene Mutation Database (HGMD): NR4A2

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    Disorders / Diseases
    for NR4A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NR4A2 for disorders           About GeneDecksing

    OMIM gene information: 601828    OMIM disorders: --

    20/36 diseases for NR4A2 (see all 36):    About MalaCards
    rheumatoid arthritis    parkinson's disease    arthritis    attention deficit hyperactivity disorder
    maturity-onset diabetes of the young    thyroiditis    cocaine abuse    nicotine dependence
    bipolar disorder    alcohol dependence    atopic dermatitis    cushing's syndrome
    was-related disorders    alcoholism    neurodegeneration    acne
    multiple sclerosis    dermatitis    adhd    nephritis

    1 disease from the University of Copenhagen DISEASES database for NR4A2:
    Parkinson's disease

    10/20 Novoseek disease relationships for NR4A2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 75.2 52 12496759 (4), 18463503 (3), 16532445 (2), 17890097 (2) (see all 25)
    inflammatory joint disease 53.8 5 15972692 (3)
    carcinoma adrenocortical 36.4 1 15292355 (1)
    schizophrenia 31.4 29 16631355 (4), 12627459 (3), 15211629 (2), 11803525 (2) (see all 10)
    neurodegeneration 24.8 3 12401563 (1), 19821032 (1)
    adenoma 17.3 4 16293616 (1), 15292355 (1), 15666793 (1)
    arthritis psoriatic 15 1 15972692 (1)
    genetic susceptibility 14 3 16690213 (1), 11840500 (1)
    bipolar disorder 13.5 9 16631355 (3), 11121187 (2), 15635645 (1)
    neurological disorders 5.36 1 18684475 (1)

    GeneTests: NR4A2
    Parkinson Disease

    Genetic Association Database (GAD): NR4A2
    Human Genome Epidemiology (HuGE) Navigator: NR4A2 (35 documents)

    Export disorders for NR4A2 gene to outside databases

    Publications
    for NR4A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR4A2 gene, integrated from 9 sources (see all 263):
    (articles sorted by number of sources associating them with NR4A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. (PubMed id 7706727)1, 2, 3, 9 Okabe T.... Watanabe T. (1995)
    2. Organization of the human orphan nuclear receptor Nurr1 gene. (PubMed id 10216261)1, 2, 9 Torii T.... Kawakami H. (1999)
    3. Mutations in NR4A2 associated with familial Parkinson disease. (PubMed id 12496759)1, 4, 9 Le W.D....Vassilatis D.K. (2003)
    4. Genetic analysis of Nurr1 haplotypes in Parkinson's disease. (PubMed id 12875905)1, 4, 9 Tan E.K....Wong M.C. (2003)
    5. Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia. (PubMed id 12627459)1, 4, 9 Iwayama-Shigeno Y....Yoshikawa T. (2003)
    6. Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. (PubMed id 11914402)1, 4, 9 Xu P.Y....Le W.D. (2002)
    7. Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease. (PubMed id 15197702)1, 4, 9 Nichols W.C....Foroud T. (2004)
    8. NR4A2 and schizophrenia: lack of association in a Portuguese/Brazilian study. (PubMed id 15211629)1, 4, 9 Ruano D....Palha J.A. (2004)
    9. NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. (PubMed id 12815740)1, 4, 9 Carmine A....Olson L. (2003)
    10. Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients. (PubMed id 11803525)1, 4, 9 Chen Y.H....Chen C.H. (2001)

    External Searches for NR4A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NR4A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4929 HGNC: 7981 AceView: NR4A2 Ensembl:ENSG00000153234 euGenes: HUgn4929
    ECgene: NR4A2 H-InvDB: NR4A2

    Other Databases showing NR4A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NR4A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR4A2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NR4A2

    Intellectual Property
    for NR4A2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NR4A2 gene:
    Search GeneIP for patents involving NR4A2

    Licensable Technologies for NR4A2 gene:
     Salk Institute: Regulation of Tyrosine Hydroxylase Expression
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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