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NR4A2 Gene

protein-coding   GIFtS: 65
GCID: GC02M157180

Nuclear Receptor Subfamily 4, Group A, Member 2


(Previous symbol: NURR1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Subfamily 4, Group A, Member 21 2     Intermediate-Early Receptor Protein2
NURR11 2 3 5     NGFI-B/Nur77 Beta-Type Transcription Factor Homolog2
NOT2 3 5     Nuclear Receptor Related 12
TINUR2 3 5     Nuclear Receptor Subfamily 4 Group A Member 22
Immediate-Early Response Protein NOT2 3     Nur Related Protein-1, Human Homolog Of2
Orphan Nuclear Receptor NURR12 3     Orphan Nuclear Receptor NR4A22
Transcriptionally-Inducible Nuclear Receptor2 3     T-Cell Nuclear Receptor NOT2
HZF-32     Transcriptionally Inducible Nuclear Receptor Related 12
RNR12     

External Ids:    HGNC: 79811   Entrez Gene: 49292   Ensembl: ENSG000001532347   OMIM: 6018285   UniProtKB: P433543   

Export aliases for NR4A2 gene to outside databases

Previous GC identifers: GC02M155112 GC02M155709 GC02M157144 GC02M157383 GC02M157006 GC02M156889 GC02M149066


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NR4A2 Gene:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may
act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic
dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be
associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their
biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for NR4A2 Gene:
NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein-coding gene. Diseases associated with NR4A2 include lrrk2-related parkinson disease, and parkinson disease 1. GO annotations related to this gene include steroid hormone receptor activity and sequence-specific DNA binding. An important paralog of this gene is NR4A3.

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
Function: Transcriptional regulator which is important for the differentiation and maintenance of
meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes
such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)

Gene Wiki entry for NR4A2 (Nuclear receptor related 1 protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR4A2 gene promoter:
         ATF-2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR4A2 promoter sequence
   Search Chromatin IP Primers for NR4A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR4A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22-q23   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q22-q23

NR4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR4A2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M157180:  view genomic region     (about GC identifiers)

Start:
157,180,944 bp from pter      End:
157,198,860 bp from pter
Size:
17,917 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 4 group A member 2  
Size: 598 amino acids; 66591 Da
Subunit: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3
(By similarity)
Developmental stage: Rapidly and only very transiently expressed after cell activation, during the G0-G1
transition of the cell cycle
1 PDB 3D structure from and Proteopedia for NR4A2:
1OVL (3D)    
Secondary accessions: Q16311 Q53RZ2

Explore the universe of human proteins at neXtProt for NR4A2: NX_P43354

Explore proteomics data for NR4A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NR4A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006177.1  
    ENSEMBL proteins: 
     ENSP00000344479   ENSP00000389986   ENSP00000386747   ENSP00000415632   ENSP00000394671  
     ENSP00000386993   ENSP00000410952   ENSP00000385379   ENSP00000406808   ENSP00000388120  
     ENSP00000444925  
    Reactome Protein details: P43354

    NR4A2 Human Recombinant Protein Products:

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    Novus Biologicals NR4A2 Protein
    Novus Biologicals NR4A2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NR4A2 Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Nuclear receptor related 1
    4A. Nerve growth factor IB-like receptors

    Selected InterPro protein domains (see all 7):
     IPR003073 NURR_rcpt
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P43354

    ProtoNet protein and cluster: P43354

    3 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003070 Orphan nuclear receptor (4A nuclear receptor) family signature
    IPB003073 Orphan nuclear receptor NURR signature


    UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
    Domain: the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from
    several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a 'classical' binding
    site for coactivators (PubMed:12774125)
    Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    NR4A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR4A2_HUMAN, P43354
    Function: Transcriptional regulator which is important for the differentiation and maintenance of
    meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes
    such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)

         Genatlas biochemistry entry for NR4A2:
    nuclear receptor subfamily 4,group A,member 2,steroid/thyroid receptor superfamily,rapidly and transiently
    expressed after cell activation,exclusively in the brain,likely functioning as a general coactivation of gene
    transcription,NGF1-B/nur 77

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI--
         
    NR4A2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NR4A2:
     G0/1 arrest  Increased G1 DNA content  Increased cell number in G2M,   Increased cell size 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nr4a2):
     behavior/neurological  cellular  digestive/alimentary  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  nervous system 

    NR4A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NR4A2: Nr4a2tm1Omc Nr4a2tm1Tpe Nr4a2tm1Niko

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR4A2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR4A2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR4A2

    miRNA
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    miRTarBase miRNAs that target NR4A2:
    hsa-mir-372-3p (MIRT003538), hsa-mir-335-5p (MIRT018465), hsa-mir-19a-3p (MIRT003536), hsa-mir-133a-3p (MIRT045837), hsa-mir-217 (MIRT003535), hsa-mir-302d-3p (MIRT003537)

    Block miRNA regulation of human, mouse, rat NR4A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR4A2 (see all 90):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-1224-3p hsa-miR-30d hsa-miR-374a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidNR4A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NR4A2
    Predesigned siRNA for gene silencing in human, mouse, rat NR4A2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NR4A2 (NM_006186)
    Sino Biological Human cDNA Clone for NR4A2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR4A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR4A2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NR4A2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR4A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NR4A2_HUMAN, P43354: Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17184956
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    NR4A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NR4A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Selected targets of CREB1
    Selected targets of CREB1
    4Corticotropin-releasing hormone
    Corticotropin-releasing hormone

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NR4A2
        Nuclear Receptors
    Corticotropin-releasing hormone


    1 Reactome Pathway for NR4A2
        Nuclear Receptor transcription pathway



    NR4A2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR4A2: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Parkinson's Disease in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR4A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NR4A2 (P433541, 3 ENSP000003444794) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEAL5Q5H9L21, 3EBI-2681738,EBI-2681773 I2D: score=1 
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    TNFP013753, ENSP000003986984I2D: score=1 STRING: ENSP00000398698
    RXRBP287023, ENSP000003638124I2D: score=2 STRING: ENSP00000363812
    ENSG00000204490P013753I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001764neuron migration IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006351transcription, DNA-templated IDA17184956
    GO:0006355regulation of transcription, DNA-templated ----

    NR4A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NR4A2

    Selected Novoseek inferred chemical compound relationships for NR4A2 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nor 1 91.4 17 14525795 (2), 18945812 (2), 12351928 (2), 12770726 (1) (see all 13)
    dopamine 69.8 104 20049900 (7), 12915123 (7), 19522012 (5), 15340833 (4) (see all 39)
    tyrosine 56.4 28 17184956 (2), 12496759 (1), 14659823 (1), 17890097 (1) (see all 24)
    retinoic acid 42.2 7 9636132 (1), 12130634 (1), 11602619 (1), 20195526 (1) (see all 6)
    retinoid 38.7 8 7705655 (1), 9636132 (1), 12122012 (1), 15635645 (1)
    forskolin 35.1 5 15106839 (3), 9931442 (1)
    steroid 33 8 7706727 (1), 10601324 (1), 10216261 (1), 11803525 (1) (see all 7)
    pd 98,059 26.4 4 15106839 (1), 17890097 (1)
    3beta-hydroxysteroid 24.2 1 15666793 (1)
    6 mercaptopurine 22.5 7 12709433 (3)



    NR4A2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NR4A2 gene (4 alternative transcripts): 
    NM_006186.3  NM_173171.1  NM_173172.1  NM_173173.1  

    Unigene Cluster for NR4A2:

    Nuclear receptor subfamily 4, group A, member 2
    Hs.563344  [show with all ESTs]
    Unigene Representative Sequence: NM_006186
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339562(uc021vri.1 uc002tyz.4 uc002tyx.4 uc010zcf.2)
    ENST00000426264 ENST00000409572 ENST00000417764(uc010zcg.1) ENST00000417972
    ENST00000409108 ENST00000429376 ENST00000406048 ENST00000424077 ENST00000421709
    ENST00000539077

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    Selected qRT-PCR Assays for microRNAs that regulate NR4A2 (see all 90):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-300 hsa-miR-106a hsa-miR-1224-3p hsa-miR-30d hsa-miR-374a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidNR4A2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: NR4A2 (NM_006186)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat NR4A2
      QuantiFast Probe-based Assays in human, mouse, rat NR4A2

    Additional mRNA sequence: 

    AK223625.1 AK291456.1 AK299439.1 AK309786.1 BC009288.2 BC066890.1 FJ643484.1 FJ643485.1 
    HQ692824.1 HQ709176.1 S77154.1 X75918.1 

    13 DOTS entries:

    DT.415336  DT.95375793  DT.100026308  DT.95351510  DT.40280240  DT.120951451  DT.415337  DT.86997413 
    DT.100026305  DT.120951440  DT.120951461  DT.91760528  DT.95375796 

    Selected AceView cDNA sequences (see all 126):

    F10268 F02834 NM_173172 CD515223 NM_173173 NM_173171 AI280196 NM_006186 
    AA235472 CB850547 BC066890 AA481687 AA481451 AA461422 BE047656 BQ718404 
    BE645908 AI978937 CA447520 AA454469 CA393074 CA396488 AW469461 AI863315 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NR4A2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:              -     -                                                                                                   
    SP2:              -     -           -     -                                                                                 
    SP3:                                                                                                        -               
    SP4:              -     -           -                                                                                       
    SP5:                    -                                                                                                   


    ECgene alternative splicing isoforms for NR4A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NR4A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATGAAAA
    NR4A2 Expression
    About this image


    NR4A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
             Cerebral Cortex
             Dopaminergic neuron-like cells
     
     Neurons
             Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
             Dopaminergic neuron-like cells
     
     Dopaminergic Neurons (Nervous System)    fully expand to see all 10 entries
             Dopaminergic neuron-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
    NR4A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR4A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.563344

    UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
    Tissue specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression
    in brain tissue

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR4A2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NR4A2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr4a21 , 5 nuclear receptor subfamily 4, group A, member 21, 5 93.59(n)1
    99.5(a)1
      2 (31.66 cM)5
    182271  NM_001139509.11  NP_001132981.11 
     571068305 
    chicken
    (Gallus gallus)
    Aves NR4A21 nuclear receptor subfamily 4, group A, member 2 87.18(n)
    94.82(a)
      424320  XM_422166.4  XP_422166.2 
    lizard
    (Anolis carolinensis)
    Reptilia NR4A26
    nuclear receptor subfamily 4, group A, member 2
    77(a)
    1 ↔ 1
    GL343254.1(1061974-1081404)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nr4a21 nuclear receptor subfamily 4, group A, member 2 80.71(n)
    92.55(a)
      100101682  NM_001100208.1  NP_001093678.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.128032 Transcribed sequence with weak similarity to protein more 77.16(n)    57095867 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hr383 epidermal differentiation
    ligand-dependent nuclear more
    68(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-63 Zinc finger, C4 type (two domains) \;
    Ligand-binding more
    35(a)   III(3645511-3650202)   --


    ENSEMBL Gene Tree for NR4A2 (if available)
    TreeFam Gene Tree for NR4A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NR4A2 gene
    NR4A32  ESRRA2  NR3C22  NR4A12  PGR2  ESR22  NR3C12  AR2  
    ESRRB2  ESR12  ESRRG2  
    Selected SIMAP similar genes for NR4A2 using alignment to 13 protein entries:     NR4A2_HUMAN (see all proteins) (see all similar genes):
    DKFZp779O0162    NR5A2    HNF4G    RORA    NR5A1    NR6A1
    ESR1    HNF4alpha    DKFZp451G125    THRB    NR4A3    NR1I3
    NR4A1    VDR    BCOR-RARA    NR3C2    RORC    NR2C2

    NR4A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NR4A2 (see all 204)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101699311,2
    C,F--156581530(+) CTTTCT/CCCATG 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1823116891,2
    --156581569(+) AAAATC/TGGAGA 1 -- ds50010--------
    rs1872845431,2
    --156581639(+) AATCAC/TTGTGC 1 -- ds50010--------
    rs1920388351,2
    C--156581645(+) TGTGCA/GAGACA 1 -- ds50010--------
    rs765717371,2
    C,F--156581712(+) CTTCTC/TTCCTG 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1148884021,2
    C,F--156581714(+) TCTCTC/TCTGAA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1460525291,2
    --156581743(+) AGTTAA/GCAGAA 1 -- ds50010--------
    rs1168876011,2
    F--156581771(+) ATTGAT/CCCTAA 1 -- ds50011Minor allele frequency- C:0.04EA 120
    rs1389049601,2
    --156581834(+) GAATTA/TTCTGC 1 -- ds50010--------
    rs11501471,2
    C,F,A--156581839(+) ATCTGC/GATAAT 1 -- ds500110Minor allele frequency- G:0.50EA NA WA 1112

    HapMap Linkage Disequilibrium report for NR4A2 (157180944 - 157198860 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NR4A2: --
    Human Gene Mutation Database (HGMD): NR4A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR4A2
    DNA2.0 Custom Variant and Variant Library Synthesis for NR4A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601828    OMIM disorders: --

    Selected diseases for NR4A2 (see all 34):    
    About MalaCards
    lrrk2-related parkinson disease    parkinson disease 1    cocaine abuse    parkinson's disease
    rheumatoid arthritis    arthritis    bipolar disorder    nicotine dependence
    alcohol dependence    attention deficit hyperactivity disorder    acne    cushing's syndrome
    was-related disorders    maturity-onset diabetes of the young    thyroiditis    schizophrenia
    atopic dermatitis    nephritis    dermatitis    psoriasis

    1 disease from the University of Copenhagen DISEASES database for NR4A2:
    Parkinson's disease

    NR4A2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for NR4A2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 75.2 52 12496759 (4), 18463503 (3), 16532445 (2), 17890097 (2) (see all 25)
    inflammatory joint disease 53.8 5 15972692 (3)
    carcinoma adrenocortical 36.4 1 15292355 (1)
    schizophrenia 31.4 29 16631355 (4), 12627459 (3), 15211629 (2), 11803525 (2) (see all 10)
    neurodegeneration 24.8 3 12401563 (1), 19821032 (1)
    adenoma 17.3 4 16293616 (1), 15292355 (1), 15666793 (1)
    arthritis psoriatic 15 1 15972692 (1)
    genetic susceptibility 14 3 16690213 (1), 11840500 (1)
    bipolar disorder 13.5 9 16631355 (3), 11121187 (2), 15635645 (1)
    neurological disorders 5.36 1 18684475 (1)

    GeneTests: NR4A2
    GeneReviews: NR4A2
    Genetic Association Database (GAD): NR4A2
    Human Genome Epidemiology (HuGE) Navigator: NR4A2 (35 documents)

    Export disorders for NR4A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NR4A2 gene, integrated from 10 sources (see all 275):
    (articles sorted by number of sources associating them with NR4A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. (PubMed id 7706727)1, 2, 3, 9 Okabe T.... Watanabe T. (J. Immunol. 1995)
    2. Organization of the human orphan nuclear receptor Nurr1 gene. (PubMed id 10216261)1, 2, 9 Torii T.... Kawakami H. (Gene 1999)
    3. Haplotypes of the NR4A2/NURR1 gene and cardiovascular disease: the Rotterdam Study. (PubMed id 19156841)1, 4, 9 Kardys I....de Maat M.P. (Hum. Mutat. 2009)
    4. Mutations in NR4A2 associated with familial Parkinson disease. (PubMed id 12496759)1, 4, 9 Le W.D....Vassilatis D.K. (Nat. Genet. 2003)
    5. Translated mutation in the Nurr1 gene as a cause for Parkinson's disease. (PubMed id 16532445)1, 4, 9 Grimes D.A....Bulman D.E. (Mov. Disord. 2006)
    6. Genetic analysis of Nurr1 haplotypes in Parkinson's disease. (PubMed id 12875905)1, 4, 9 Tan E.K....Wong M.C. (Neurosci. Lett. 2003)
    7. Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia. (PubMed id 12627459)1, 4, 9 Iwayama-Shigeno Y....Yoshikawa T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    8. Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. (PubMed id 11914402)1, 4, 9 Xu P.Y....Le W.D. (Neurology 2002)
    9. Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease. (PubMed id 15197702)1, 4, 9 Nichols W.C....Foroud T. (Mov. Disord. 2004)
    10. NR4A2 and schizophrenia: lack of association in a Portuguese/Brazilian study. (PubMed id 15211629)1, 4, 9 Ruano D....Palha J.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4929 HGNC: 7981 AceView: NR4A2 Ensembl:ENSG00000153234 euGenes: HUgn4929
    ECgene: NR4A2 H-InvDB: NR4A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NR4A2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/gtr/tests/299416/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NR4A2 gene:
    Search GeneIP for patents involving NR4A2

    Licensable Technologies for NR4A2 gene:
     Salk Institute: Regulation of Tyrosine Hydroxylase Expression
    GeneCards and IP:
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