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Aliases for NR4A2 Gene

Aliases for NR4A2 Gene

  • Nuclear Receptor Subfamily 4, Group A, Member 2 2 3
  • Transcriptionally-Inducible Nuclear Receptor 3 4
  • Immediate-Early Response Protein NOT 3 4
  • Orphan Nuclear Receptor NURR1 3 4
  • NURR1 3 4
  • TINUR 3 4
  • NOT 3 4
  • Transcriptionally Inducible Nuclear Receptor Related 1 3
  • NGFI-B/Nur77 Beta-Type Transcription Factor Homolog 3
  • Nur Related Protein-1, Human Homolog Of 3
  • Intermediate-Early Receptor Protein 3
  • Orphan Nuclear Receptor NR4A2 3
  • T-Cell Nuclear Receptor NOT 3
  • Nuclear Receptor Related 1 3
  • HZF-3 3
  • RNR1 3

External Ids for NR4A2 Gene

Previous HGNC Symbols for NR4A2 Gene

  • NURR1

Previous GeneCards Identifiers for NR4A2 Gene

  • GC02M155112
  • GC02M155709
  • GC02M157144
  • GC02M157383
  • GC02M157006
  • GC02M156889
  • GC02M149066
  • GC02M157180

Summaries for NR4A2 Gene

Entrez Gene Summary for NR4A2 Gene

  • This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NR4A2 Gene

NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2) is a Protein Coding gene. Diseases associated with NR4A2 include extraosseous chondrosarcoma and chondrosarcoma, extraskeletal myxoid. Among its related pathways are Corticotropin-releasing hormone and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is AR.

UniProtKB/Swiss-Prot for NR4A2 Gene

  • Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

Gene Wiki entry for NR4A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR4A2 Gene

Genomics for NR4A2 Gene

Regulatory Elements for NR4A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NR4A2 Gene

Chromosome:
2
Start:
156,324,432 bp from pter
End:
156,342,348 bp from pter
Size:
17,917 bases
Orientation:
Minus strand

Genomic View for NR4A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR4A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR4A2 Gene

Proteins for NR4A2 Gene

  • Protein details for NR4A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43354-NR4A2_HUMAN
    Recommended name:
    Nuclear receptor subfamily 4 group A member 2
    Protein Accession:
    P43354
    Secondary Accessions:
    • Q16311
    • Q53RZ2
    • Q6NXU0

    Protein attributes for NR4A2 Gene

    Size:
    598 amino acids
    Molecular mass:
    66591 Da
    Quaternary structure:
    • Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NR4A2 Gene

    Alternative splice isoforms for NR4A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR4A2 Gene

Proteomics data for NR4A2 Gene at MOPED

Post-translational modifications for NR4A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for NR4A2 (Nurr1/NGFI-B beta/NR4A2)

No data available for DME Specific Peptides for NR4A2 Gene

Domains & Families for NR4A2 Gene

Gene Families for NR4A2 Gene

Graphical View of Domain Structure for InterPro Entry

P43354

UniProtKB/Swiss-Prot:

NR4A2_HUMAN :
  • the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a classical binding site for coactivators (PubMed:12774125).
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.
Domain:
  • the ligand-binding domain (LBD) contains no cavity as a result of the tight packing of side chains from several bulky hydrophobic residues in the region normally occupied by ligands. NR4A2 lacks a classical binding site for coactivators (PubMed:12774125).
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.
genes like me logo Genes that share domains with NR4A2: view

Function for NR4A2 Gene

Molecular function for NR4A2 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 4,group A,member 2,steroid/thyroid receptor superfamily,rapidly and transiently expressed after cell activation,exclusively in the brain,likely functioning as a general coactivation of gene transcription,NGF1-B/nur 77
UniProtKB/Swiss-Prot Function:
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

Gene Ontology (GO) - Molecular Function for NR4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISS --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding --
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with NR4A2: view
genes like me logo Genes that share phenotypes with NR4A2: view

Animal Models for NR4A2 Gene

MGI Knock Outs for NR4A2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NR4A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NR4A2 Gene

Localization for NR4A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR4A2 Gene

Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR4A2 Gene COMPARTMENTS Subcellular localization image for NR4A2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NR4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17184956
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NR4A2: view

Pathways & Interactions for NR4A2 Gene

genes like me logo Genes that share pathways with NR4A2: view

Pathways by source for NR4A2 Gene

1 KEGG pathway for NR4A2 Gene
1 GeneGo (Thomson Reuters) pathway for NR4A2 Gene

PCR Array Products

SIGNOR curated interactions for NR4A2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR4A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001764 neuron migration IEA --
GO:0001975 response to amphetamine IEA --
GO:0006351 transcription, DNA-templated IDA 17184956
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with NR4A2: view

Drugs & Compounds for NR4A2 Gene

(10) Drugs for NR4A2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 2814
Norepinephrine Approved Pharma 206
cholesterol Experimental Pharma Agonist 0
Forskolin Experimental Pharma 0
ACTH Pharma 0

(11) Additional Compounds for NR4A2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3beta-Hydroxysteroid
6 mercaptopurine
6-hydroxydopamine
  • 2,4,5-Trihydroxyphenethylamine
  • 5-(2-Aminoethyl)-1,2,4-benzenetriol
  • 6-Hydroxy-Dopamine
  • 6-Hydroxydopamine
  • Topamine
1199-18-4
Cycloheximide
gaba
56-12-2
genes like me logo Genes that share compounds with NR4A2: view

Transcripts for NR4A2 Gene

Unigene Clusters for NR4A2 Gene

Nuclear receptor subfamily 4, group A, member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NR4A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR4A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - - -
SP3: -
SP4: - - -
SP5: -
SP6: - -
SP7: - - - -
SP8: - - -
SP9: - - - - -

Relevant External Links for NR4A2 Gene

GeneLoc Exon Structure for
NR4A2
ECgene alternative splicing isoforms for
NR4A2

Expression for NR4A2 Gene

mRNA expression in normal human tissues for NR4A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR4A2 Gene

This gene is overexpressed in Ovary (x6.7).

Protein differential expression in normal tissues from HIPED for NR4A2 Gene

This gene is overexpressed in Adipocyte (55.7) and Bone (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NR4A2 Gene



SOURCE GeneReport for Unigene cluster for NR4A2 Gene Hs.563344

mRNA Expression by UniProt/SwissProt for NR4A2 Gene

P43354-NR4A2_HUMAN
Tissue specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue
genes like me logo Genes that share expression patterns with NR4A2: view

Protein tissue co-expression partners for NR4A2 Gene

Primer Products

In Situ Assay Products

Orthologs for NR4A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR4A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NR4A2 35
  • 96.21 (n)
  • 99.83 (a)
NR4A2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR4A2 35
  • 96.99 (n)
  • 99.83 (a)
NR4A2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr4a2 35
  • 93.59 (n)
  • 99.5 (a)
Nr4a2 16
Nr4a2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NR4A2 35
  • 99.78 (n)
  • 100 (a)
NR4A2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr4a2 35
  • 93.59 (n)
  • 99.67 (a)
oppossum
(Monodelphis domestica)
Mammalia NR4A2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR4A2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR4A2 35
  • 87.18 (n)
  • 94.82 (a)
NR4A2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR4A2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr4a2 35
  • 80.71 (n)
  • 92.55 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12803 35
nr4a2a 35
  • 77.18 (n)
  • 87.92 (a)
nr4a2a 36
  • 82 (a)
OneToMany
nr4a2b 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Hr38 37
  • 68 (a)
Hr38 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhr-6 37
  • 35 (a)
nhr-6 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for NR4A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR4A2 Gene

ENSEMBL:
Gene Tree for NR4A2 (if available)
TreeFam:
Gene Tree for NR4A2 (if available)

Paralogs for NR4A2 Gene

Paralogs for NR4A2 Gene

genes like me logo Genes that share paralogs with NR4A2: view

Variants for NR4A2 Gene

Sequence variations from dbSNP and Humsavar for NR4A2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs12803 -- 156,325,413(-) TATAA(G/T)GTATA utr-variant-3-prime
rs707129 -- 156,333,886(+) TGGCT(C/G)TGGGA upstream-variant-2KB, utr-variant-5-prime, nc-transcript-variant
rs834834 -- 156,327,123(+) AATTG(C/T)CATTT intron-variant
rs834835 -- 156,331,633(+) CCTAG(C/T)AATTT intron-variant
rs834836 -- 156,332,499(+) CGTCT(C/G)TCTTC utr-variant-5-prime, reference, missense, nc-transcript-variant

Variation tolerance for NR4A2 Gene

Residual Variation Intolerance Score: 27.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NR4A2 Gene

HapMap Linkage Disequilibrium report
NR4A2
Human Gene Mutation Database (HGMD)
NR4A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NR4A2 Gene

Disorders for NR4A2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for NR4A2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
extraosseous chondrosarcoma
  • extraskeletal myxoid chondrosarcoma
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
parkinson disease, late-onset
  • kufor-rakeb syndrome
alcohol dependence
  • alcohol dependence, protection against
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association
Search NR4A2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NR4A2

Genetic Association Database (GAD)
NR4A2
Human Genome Epidemiology (HuGE) Navigator
NR4A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR4A2
genes like me logo Genes that share disorders with NR4A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NR4A2 Gene

Publications for NR4A2 Gene

  1. cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. (PMID: 7706727) Okabe T. … Watanabe T. (J. Immunol. 1995) 2 23 67
  2. Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancer. (PMID: 19908257) Inamoto T. … Kamat A.M. (Cancer 2010) 23 67
  3. Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival. (PMID: 20049900) Lee H.S. … Lee S.H. (Stem Cells 2010) 23 67
  4. Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. (PMID: 20195526) Tio M. … Udolph G. (PLoS ONE 2010) 23 67
  5. Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation. (PMID: 20421523) Bonta P.I. … de Vries C.J. (Circulation 2010) 23 67

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Sources for NR4A2 Gene

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