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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR4A1 Gene

protein-coding   GIFtS: 66
GCID: GC12P052416

Nuclear Receptor Subfamily 4, Group A, Member 1


(Previous symbols: HMR, GFRP1)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 4, Group A, Member 11 2     NGFIB2
GFRP11 2 3 5     NUR772
HMR1 2 3 5     TR32
Early Response Protein NAK12 3     Growth Factor-Inducible Nuclear Protein N102
Nuclear Hormone Receptor NUR/772 3     Hormone Receptor2
Orphan Nuclear Receptor HMR2 3     Nerve Growth Factor IB Nuclear Receptor Variant 12
Orphan Nuclear Receptor TR32 3     Nuclear Receptor Subfamily 4 Group A Member 12
Testicular Receptor 32 3     Steroid Receptor TR32
ST-592 3     TR3 Orphan Receptor2
NP102 5     NAK13
N102     Nur773
NAK-12     

External Ids:    HGNC: 79801   Entrez Gene: 31642   Ensembl: ENSG000001233587   OMIM: 1391395   UniProtKB: P227363   

Export aliases for NR4A1 gene to outside databases

Previous GC identifers: GC12M052494 GC12P052474 GC12P052154 GC12P050723 GC12P050717 GC12P052432 GC12P049478


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR4A1 Gene:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by
phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein
acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces
apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2011)

GeneCards Summary for NR4A1 Gene: 
NR4A1 (nuclear receptor subfamily 4, group A, member 1) is a protein-coding gene. Diseases associated with NR4A1 include pancreatic cancer 1, and staphyloenterotoxemia, and among its related super-pathways are Nuclear Receptors and MAPK signaling pathway. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early
genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May
inhibit NF-kappa-B transactivation of IL2

Gene Wiki entry for NR4A1 (Nerve Growth factor IB) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR4A1 gene promoter:
         SRF   CREB   Max1   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR4A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR4A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR4A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

NR4A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR4A1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P052416:  view genomic region     (about GC identifiers)

Start:
52,416,616 bp from pter      End:
52,453,291 bp from pter
Size:
36,676 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 4 group A member 1  
Size: 598 amino acids; 64463 Da
Subunit: Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1
Subcellular location: Nucleus
3 PDB 3D structures from and Proteopedia for NR4A1:
2QW4 (3D)        3V3E (3D)        3V3Q (3D)    
Secondary accessions: B4DML7
Alternative splicing: 2 isoforms:  P22736-1   P22736-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NR4A1: NX_P22736

Explore proteomics data for NR4A1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22736

  • NR4A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NR4A1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001189162.1  NP_002126.2  NP_775180.1  

    ENSEMBL proteins: 
     ENSP00000456633   ENSP00000457070   ENSP00000456776   ENSP00000440864   ENSP00000449539  
     ENSP00000449858   ENSP00000378301   ENSP00000449587   ENSP00000455399   ENSP00000455767  
     ENSP00000353427   ENSP00000243050   ENSP00000378302  
    Reactome Protein details: P22736
    Human Recombinant Protein Products for NR4A1: 
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    Novus Biologicals NR4A1 Proteins
    Novus Biologicals NR4A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    NR4A1 for ontologies           About GeneDecksing



    NR4A1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Nerve Growth factor IB 
    4A. Nerve growth factor IB-like receptors

    5/7 InterPro protein domains (see all 7):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P22736

    ProtoNet protein and cluster: P22736

    3 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003070 Orphan nuclear receptor (4A nuclear receptor) family signature
    IPB003071 Orphan nuclear receptor HMR signature


    UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
    Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    NR4A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR4A1_HUMAN, P22736
    Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early
    genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May
    inhibit NF-kappa-B transactivation of IL2
    Induction: By growth-stimulating agents

         Genatlas biochemistry entry for NR4A1:
    nuclear receptor subfamily 4,group A,member 1,steroid/thyroid receptor superfamily,likely functionning as a
    general coactivation of gene transcription

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
         
    NR4A1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nr4a1):
     behavior/neurological  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     integument  liver/biliary system  mortality/aging  tumorigenesis 

    NR4A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nr4a1tm1Jmi for NR4A1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NR4A1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR4A1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR4A1 

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    SwitchGear 3'UTR luciferase reporter plasmidNR4A1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): NR4A1 (NM_002135)
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                         Customized lentivirus expression plasmids for stable overexpression of NR4A1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR4A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NR4A1 About   (see all 26)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    Nuclear Receptors0.68
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    4PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    5Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for NR4A1
        Immune response Function of MEF2 in T lymphocytes
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NR4A1
        NK1R-mediated Non-Apoptotic PCD
    Nur77-Induced AICD in Macrophage
    Calcium Mediated T-Cell Apoptosis
    Nur77 Signaling in T-Cell
    CRHR Pathway

    3 Cell Signaling Technology (CST) Pathways for NR4A1
        Apoptosis and Autophagy
    Lymphocyte Signaling
    PI3K / Akt Signaling

    2 GeneGo (Thomson Reuters) Pathways for NR4A1
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Immune response Function of MEF2 in T lymphocytes

    5/6 BioSystems Pathways for NR4A1 (see all 6)
        MAPK signaling pathway
    Nuclear Receptors
    Spinal Cord Injury
    Glucocorticoid receptor regulatory network
    RXR and RAR heterodimerization with other nuclear receptor

    5/35        Reactome Pathways for NR4A1 (see all 35)
        Nuclear Receptor transcription pathway
    Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF


    2         Kegg Pathways  (Kegg details for NR4A1):
        MAPK signaling pathway
    PI3K-Akt signaling pathway


    NR4A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR4A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/164 Interacting proteins for NR4A1 (P227361, 2, 3 ENSP000002430504) via UniProtKB, MINT, STRING, and/or I2D (see all 164)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-4049673 MINT-4049732 MINT-4049598 MINT-4049689 MINT-4049708 MINT-4049650 I2D: score=3 STRING: ENSP00000269305
    BCL2P104151, 3, ENSP000003296234EBI-721550,EBI-77694 I2D: score=4 STRING: ENSP00000329623
    ATXN1P542532, 3, ENSP000002447694MINT-2859701 I2D: score=3 STRING: ENSP00000244769
    PRDX4Q131622, 3, ENSP000003686464MINT-8264116 I2D: score=2 STRING: ENSP00000368646
    CUTAO608881, 3EBI-721550,EBI-1051556 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IMP18059339
    GO:0002042cell migration involved in sprouting angiogenesis IDA18059339
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006915apoptotic process ----

    NR4A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NR4A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR4A1

    10/55 Novoseek inferred chemical compound relationships for NR4A1 gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nor 1 92.5 26 10773199 (4), 17096060 (3), 18945812 (2), 15947483 (2) (see all 14)
    ru 26752 84 3 8639467 (2)
    18-vinylprogesterone 81.5 2 7588320 (1), 8068005 (1)
    cd 437 69.8 9 9671482 (4), 16434970 (2), 17150035 (2)
    steroid 62.5 45 1922099 (3), 1655735 (1), 7849260 (1), 15128284 (1) (see all 35)
    retinoid 56.3 13 12082103 (1), 15494375 (1), 10772826 (1), 7705655 (1) (see all 10)
    retinoic acid 48.4 47 14592536 (5), 10772826 (5), 15494375 (4), 9130711 (3) (see all 12)
    forskolin 43.8 14 15615861 (3), 16002533 (3), 15128284 (1), 11174853 (1) (see all 6)
    spironolactone 42.4 1 8068005 (1)
    acth 39.7 20 9322922 (6), 9592111 (3), 10340952 (2), 9496246 (2) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about NR4A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NR4A1 gene (5 alternative transcripts): 
    NM_001202233.1  NM_002135.4  NM_173157.2  NM_001202234.1  NM_173158.1  

    Unigene Clusters for NR4A1:

    Nuclear receptor subfamily 4, group A, member 1
    Hs.524430  [show with all ESTs], Hs.670088  [show with all ESTs]
    Unigene Representative Sequences: AK131566, D85245
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000548977 ENST00000546842 ENST00000553200 ENST00000545748(uc010sno.2)
    ENST00000550082 ENST00000549102 ENST00000478250(uc001rzr.2 uc009zmb.2)
    ENST00000547206 ENST00000550763 ENST00000394824(uc009zmc.3) ENST00000548232
    ENST00000562373 ENST00000548733 ENST00000550557 ENST00000564201 ENST00000550339
    ENST00000567890 ENST00000550582
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR4A1
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    Additional mRNA sequence: 

    AK314437.1 D85245.1 

    24/29 DOTS entries (see all 29):

    DT.100835625  DT.95211685  DT.99933453  DT.455683  DT.100677763  DT.95197080  DT.86851887  DT.95211694 
    DT.121120228  DT.95211671  DT.121120236  DT.121120215  DT.92443432  DT.91754839  DT.92017879  DT.100835627 
    DT.100835629  DT.121120237  DT.97762198  DT.97764057  DT.97819747  DT.100835623  DT.100835626  DT.100835628 

    24/423 AceView cDNA sequences (see all 423):

    D31018 AL047948 CK429599 BQ772051 BE326874 AW328183 CD245324 BU742532 
    BQ029547 CA432744 NM_173158 T28725 BM998346 CD723414 CA405635 CA445007 
    BX280956 BX280917 AL541415 CD364918 BF915025 AL047238 BQ879017 CK430678 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NR4A1 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ·
    SP1:                                                                                                                    -     -                                 
    SP2:                                            -     -     -     -     -     -     -     -     -     -                 -     -                                 
    SP3:                                                                                                                    -     -           -     -               
    SP4:                                            -     -                                                                                                         
    SP5:                                            -                                                                                                               

    ExUns: 13c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NR4A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR4A1 expression in normal human tissues (normalized intensities)      NR4A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAATACA
    NR4A1 Expression
    About this image


    NR4A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             PERIPHERAL NERVOUS SYSTEM   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Adrenal Gland (Endocrine System)
             Adrenal Cortex   

    See NR4A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR4A1

    SOURCE GeneReport for Unigene clusters: Hs.524430 Hs.670088

    UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
    Tissue specificity: Fetal muscle and adult liver, brain and thyroid

        SABiosciences Expression via Pathway-Focused PCR Arrays including NR4A1: 
              T Helper Cell Differentiation in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Apoptosis 384HT in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NR4A1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr4a11 , 5 nuclear receptor subfamily 4, group A, member 11, 5 86.29(n)1
    91.81(a)1
      15 (56.64 cM)5
    153701  NM_010444.21  NP_034574.11 
     1012668465 
    lizard
    (Anolis carolinensis)
    Reptilia NR4A16
    Uncharacterized protein
    70(a)
    1 ↔ 1
    2(92812476-92825914)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056025.12   -- 76.87(n)    BC056025.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr4a11 nuclear receptor subfamily 4, group A, member 1 62.65(n)
    61.77(a)
      431720  NM_001002173.1  NP_001002173.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hr383 epidermal differentiation
    ligand-dependent nuclear more
    64(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-61 Protein NHR-6 45.67(n)
    36.78(a)
      175462  NM_065330.4  NP_497731.1 


    ENSEMBL Gene Tree for NR4A1 (if available)
    TreeFam Gene Tree for NR4A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR4A1 gene
    VDR2  NR4A32  RARG2  NR1I22  NR1I32  THRB2  RARA2  NR4A22  
    NR1H42  NR1H22  RARB2  THRA2  NR1H32  
    18/22 SIMAP similar genes for NR4A1 using alignment to 11 protein entries:     NR4A1_HUMAN (see all proteins) (see all similar genes):
    DKFZp451G125    HNF4G    VDR    ESR1    DKFZp779O0162    HNF4alpha
    NR1I3    NR4A2    NR3C2    NR5A1    NR4A3    RXRB
    NR2B1    RXRA    NR1B3    RARG    NR1B2    NR2B3

    NR4A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/794 SNPs in NR4A1 are shown (see all 794)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681745251,2
    C--49479285(+) ATCAC-/GTGT  
            
    GTGTG
    3 -- int10--------
    rs1867169771,2
    --52414719(+) TGGTGA/GGGAGC 1 -- us2k10--------
    rs26037471,2
    C,F--52414782(+) ACCATT/CGGGAG 1 -- us2k12Minor allele frequency- C:0.09CSA WA 120
    rs1905410301,2
    --52414829(+) CCTTCC/TTCAGC 1 -- us2k10--------
    rs1405129331,2
    --52414904(+) AGACAA/CCCTCC 1 -- us2k10--------
    rs1824290931,2
    --52415422(+) CTGCTC/TCCCTA 1 -- us2k10--------
    rs1442496861,2
    --52415447(+) CTTTAC/GTGACT 1 -- us2k10--------
    rs111699841,2
    A--52415753(+) TTTGGG/TTTTTG 1 -- us2k10--------
    rs73095471,2
    C,F,A--52415758(+) TTTTTG/TAAACA 1 -- us2k15Minor allele frequency- T:0.30NA WA EA 362
    rs619140471,2
    C,F--52415759(+) TTTTGC/AAACAG 1 -- us2k11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for NR4A1 (52416616 - 52453291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NR4A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656525CNV Deletion23128226
    dgv1425n71CNV Loss21882294
    nsv899082CNV Loss21882294
    nsv832409CNV Loss17160897
    dgv1424n71CNV Loss21882294
    nsv899079CNV Loss21882294
    nsv518451CNV Loss19592680
    nsv469378CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 139139    OMIM disorders: --

    20/48 diseases for NR4A1 (see all 48):    About MalaCards
    pancreatic cancer 1    staphyloenterotoxemia    pseudohypoaldosteronism    impetigo
    tardive dyskinesia    burkitt's lymphoma    maturity-onset diabetes of the young    stomach cancer
    cutaneous t cell lymphoma    choriocarcinoma    thyroiditis    narcolepsy
    brain injury    parkinson's disease    schizophrenia    bipolar disorder
    atopic dermatitis    gastric cancer    colon cancer    pancreatic cancer

    3 diseases from the University of Copenhagen DISEASES database for NR4A1:
    Mucoepidermoid carcinoma     Staphyloenterotoxemia     Impetigo

    NR4A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/24 Novoseek inferred disease relationships for NR4A1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudohypoaldosteronism 67 2 9141514 (1), 12788847 (1)
    mammary tumor 39 3 1648951 (1), 14500761 (1), 8070376 (1)
    carcinoma adrenocortical 29.1 1 15292355 (1)
    leukemogenesis 22.7 1 19148494 (1)
    gastric cancer 16.1 10 12376465 (4), 14592536 (2), 15601544 (2), 15494375 (1) (see all 5)
    choriocarcinoma 6.34 1 8119938 (1)
    leukemia t-cell 3.86 1 10772826 (1)
    parkinson disease 2.31 4 20096738 (1), 15956351 (1), 19635563 (1)
    burkitt lymphoma 1.13 1 7589118 (1)
    ischemia 0 2 14715474 (1), 8964794 (1)

    Genetic Association Database (GAD): NR4A1
    Human Genome Epidemiology (HuGE) Navigator: NR4A1 (4 documents)

    Export disorders for NR4A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR4A1 gene, integrated from 9 sources (see all 391):
    (articles sorted by number of sources associating them with NR4A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. (PubMed id 2626032)1, 2, 3 Chang C.... Chang Y. (1989)
    2. Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia. (PubMed id 20010315)1, 4, 9 Novak G....Le Foll B. (2010)
    3. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. (PubMed id 15466594)1, 2, 9 Harant H. and Lindley I.J. (2004)
    4. A human early response gene homologous to murine nur77 and rat NGFI- B, and related to the nuclear receptor superfamily. (PubMed id 2283997)1, 2, 9 Nakai A.... Degroot L.J. (1990)
    5. No association between variation in the NR4A1 gene lo cus and metabolic traits in white subjects at increased risk for type 2 diabete s. (PubMed id 20525362)1, 4 MA1ssig K....Staiger H. (2010)
    6. Replicated association of the NR4A3 gene with smoking behaviour in schizophrenia and in bipolar disorder. (PubMed id 20659174)1, 4 Novak G....Le Foll B. (2010)
    7. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    8. CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. (PubMed id 15459248)1, 2 Park K.C....Shong M. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3164 HGNC: 7980 AceView: NR4A1 Ensembl:ENSG00000123358 euGenes: HUgn3164
    ECgene: NR4A1 Kegg: 3164 H-InvDB: NR4A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR4A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NR4A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NR4A1 gene:
    Search GeneIP for patents involving NR4A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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