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NR4A1 Gene

protein-coding   GIFtS: 67
GCID: GC12P052416

Nuclear Receptor Subfamily 4, Group A, Member 1


(Previous symbols: HMR, GFRP1)
  See NR4A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Subfamily 4, Group A, Member 11 2     NGFIB2
GFRP11 2 3 5     NUR772
HMR1 2 3 5     TR32
Early Response Protein NAK12 3     Growth Factor-Inducible Nuclear Protein N102
Nuclear Hormone Receptor NUR/772 3     Hormone Receptor2
Orphan Nuclear Receptor HMR2 3     Nerve Growth Factor IB Nuclear Receptor Variant 12
Orphan Nuclear Receptor TR32 3     Nuclear Receptor Subfamily 4 Group A Member 12
Testicular Receptor 32 3     Steroid Receptor TR32
ST-592 3     TR3 Orphan Receptor2
NP102 5     NAK13
N102     Nur773
NAK-12     

External Ids:    HGNC: 79801   Entrez Gene: 31642   Ensembl: ENSG000001233587   OMIM: 1391395   UniProtKB: P227363   

Export aliases for NR4A1 gene to outside databases

Previous GC identifers: GC12M052494 GC12P052474 GC12P052154 GC12P050723 GC12P050717 GC12P052432 GC12P049478


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NR4A1 Gene:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by
phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein
acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces
apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2011)

GeneCards Summary for NR4A1 Gene:
NR4A1 (nuclear receptor subfamily 4, group A, member 1) is a protein-coding gene. Diseases associated with NR4A1 include staphyloenterotoxemia, and impetigo. GO annotations related to this gene include protein heterodimerization activity and protein homodimerization activity. An important paralog of this gene is NR4A3.

UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early
genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May
inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11
in the nucleus, thereby attenuating cytoplasmic AMPK activation

Gene Wiki entry for NR4A1 (Nerve Growth factor IB) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR4A1 gene promoter:
         SRF   CREB   Max1   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR4A1 promoter sequence
   Search Chromatin IP Primers for NR4A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR4A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

NR4A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR4A1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P052416:  view genomic region     (about GC identifiers)

Start:
52,416,616 bp from pter      End:
52,453,291 bp from pter
Size:
36,676 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 4 group A member 1  
Size: 598 amino acids; 64463 Da
Subunit: Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1. Interacts with STK11
Selected PDB 3D structures from and Proteopedia for NR4A1 (see all 7):
2QW4 (3D)        3V3E (3D)        3V3Q (3D)        4JGV (3D)        4KZI (3D)        4KZJ (3D)    
Secondary accessions: B4DML7 Q15627 Q53Y00 Q6IBU8
Alternative splicing: 3 isoforms:  P22736-1   P22736-2   P22736-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NR4A1: NX_P22736

Explore proteomics data for NR4A1 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli1
  • Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NR4A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001189162.1  NP_002126.2  NP_775180.1  

    ENSEMBL proteins: 
     ENSP00000456633   ENSP00000457070   ENSP00000456776   ENSP00000440864   ENSP00000449539  
     ENSP00000449858   ENSP00000378301   ENSP00000449587   ENSP00000455399   ENSP00000455767  
     ENSP00000353427   ENSP00000243050   ENSP00000378302  
    Reactome Protein details: P22736

    NR4A1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for NR4A1
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    OriGene Custom MassSpec
    OriGene Custom Protein Services for NR4A1
    GenScript Custom Purified and Recombinant Proteins Services for NR4A1
    Novus Biologicals NR4A1 Proteins
    Novus Biologicals NR4A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NR4A1 

     
    antibodies-online proteins for NR4A1 (9 products) 

     
    antibodies-online peptides for NR4A1

    NR4A1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for NR4A1
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    ThermoFisher Antibody for NR4A1
    antibodies-online antibodies for NR4A1 (109 products) 

    NR4A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NR4A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NR4A1 
    antibodies-online kits for NR4A1 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Nerve Growth factor IB
    4A. Nerve growth factor IB-like receptors

    Selected InterPro protein domains (see all 7):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P22736

    ProtoNet protein and cluster: P22736

    3 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003070 Orphan nuclear receptor (4A nuclear receptor) family signature
    IPB003071 Orphan nuclear receptor HMR signature


    UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
    Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with NR4A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR4A1_HUMAN, P22736
    Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early
    genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May
    inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11
    in the nucleus, thereby attenuating cytoplasmic AMPK activation
    Induction: By growth-stimulating agents

         Genatlas biochemistry entry for NR4A1:
    nuclear receptor subfamily 4,group A,member 1,steroid/thyroid receptor superfamily,likely functionning as a
    general coactivation of gene transcription

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
         
    Find genes that share ontologies with NR4A1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nr4a1):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     integument  liver/biliary system  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with NR4A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nr4a1tm1Jmi for NR4A1

       genOway: Develop your customized and physiologically relevant rodent model for NR4A1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  TGACCTTTNCNT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NR4A1:
    hsa-mir-93-5p (MIRT048853), hsa-let-7d-5p (MIRT032110), hsa-mir-196a-5p (MIRT026031), hsa-mir-335-5p (MIRT018925), hsa-mir-124-3p (MIRT023110)

    Block miRNA regulation of human, mouse, rat NR4A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR4A1 (see all 14):
    hsa-miR-224 hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-4272 hsa-miR-605 hsa-miR-3120-3p hsa-miR-656 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidNR4A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NR4A1
    Predesigned siRNA for gene silencing in human, mouse, rat NR4A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NR4A1

    Clone
    Products:
         
    OriGene clones in human, mouse for NR4A1 (see all 14)
    OriGene ORF clones in mouse, rat for NR4A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NR4A1 (NM_002135)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR4A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR4A1
    Addgene plasmids for NR4A1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NR4A1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NR4A1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR4A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NR4A1_HUMAN, P22736: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with NR4A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NR4A1 About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Signaling by SCF-KIT0.72
    PIP3 activates AKT signaling0.88
    Signaling by ERBB40.66
    4Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    5Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79


    Find genes that share SuperPaths with NR4A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NR4A1
        NK1R-mediated Non-Apoptotic PCD
    Nur77-Induced AICD in Macrophage
    Calcium Mediated T-Cell Apoptosis
    Nur77 Signaling in T-Cell
    CRHR Pathway

    3 Cell Signaling Technology (CST) Pathways for NR4A1
        Apoptosis and Autophagy
    Lymphocyte Signaling
    PI3K / Akt Signaling

    2 GeneGo (Thomson Reuters) Pathways for NR4A1
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Immune response Function of MEF2 in T lymphocytes

    Selected BioSystems Pathways for NR4A1 (see all 7)
        MAPK signaling pathway
    Nuclear Receptors
    Spinal Cord Injury
    Corticotropin-releasing hormone
    RXR and RAR heterodimerization with other nuclear receptor

    3 Reactome Pathways for NR4A1
        AKT phosphorylates targets in the nucleus
    Nuclear Receptor transcription pathway
    Constitutive PI3K/AKT Signaling in Cancer


    2 Kegg Pathways  (Kegg details for NR4A1):
        MAPK signaling pathway
    PI3K-Akt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR4A1: 
              T Helper Cell Differentiation in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Apoptosis 384HT in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR4A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NR4A1 (P227361, 2, 3 ENSP000002430504) via UniProtKB, MINT, STRING, and/or I2D (see all 178)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-721550,EBI-366083 MINT-4049673 MINT-4049732 MINT-4049598 MINT-4049689 MINT-4049708 MINT-4049650 I2D: score=3 STRING: ENSP00000269305
    BCL2P104151, 3, ENSP000003296234EBI-721550,EBI-77694 I2D: score=4 STRING: ENSP00000329623
    ATXN1P542532, 3, ENSP000002447694MINT-2859701 I2D: score=3 STRING: ENSP00000244769
    PRDX4Q131622, 3, ENSP000003686464MINT-8264116 I2D: score=2 STRING: ENSP00000368646
    CUTAO608881, 3EBI-721550,EBI-1051556 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IMP18059339
    GO:0002042cell migration involved in sprouting angiogenesis IDA18059339
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006915apoptotic process ----

    Find genes that share ontologies with NR4A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NR4A1

    Selected Novoseek inferred chemical compound relationships for NR4A1 gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nor 1 92.5 26 10773199 (4), 17096060 (3), 18945812 (2), 15947483 (2) (see all 14)
    ru 26752 84 3 8639467 (2)
    18-vinylprogesterone 81.5 2 7588320 (1), 8068005 (1)
    cd 437 69.8 9 9671482 (4), 16434970 (2), 17150035 (2)
    steroid 62.5 45 1922099 (3), 1655735 (1), 7849260 (1), 15128284 (1) (see all 35)
    retinoid 56.3 13 12082103 (1), 15494375 (1), 10772826 (1), 7705655 (1) (see all 10)
    retinoic acid 48.4 47 14592536 (5), 10772826 (5), 15494375 (4), 9130711 (3) (see all 12)
    forskolin 43.8 14 15615861 (3), 16002533 (3), 15128284 (1), 11174853 (1) (see all 6)
    spironolactone 42.4 1 8068005 (1)
    acth 39.7 20 9322922 (6), 9592111 (3), 10340952 (2), 9496246 (2) (see all 9)



    Find genes that share compounds with NR4A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NR4A1 gene (5 alternative transcripts): 
    NM_001202233.1  NM_002135.4  NM_173157.2  NM_001202234.1  NM_173158.1  

    Unigene Cluster for NR4A1:

    Nuclear receptor subfamily 4, group A, member 1
    Hs.524430  [show with all ESTs]
    Unigene Representative Sequence: AK131566
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000548977 ENST00000546842 ENST00000553200 ENST00000545748(uc010sno.2)
    ENST00000550082 ENST00000549102 ENST00000478250(uc001rzr.2 uc009zmb.2)
    ENST00000547206 ENST00000550763 ENST00000394824(uc009zmc.3) ENST00000548232
    ENST00000562373 ENST00000548733 ENST00000550557 ENST00000564201 ENST00000550339
    ENST00000567890 ENST00000550582
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NR4A1 (see all 14):
    hsa-miR-224 hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-4272 hsa-miR-605 hsa-miR-3120-3p hsa-miR-656 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidNR4A1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): NR4A1 (NM_002135)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR4A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR4A1
    Addgene plasmids for NR4A1 
    Primer
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    OriGene qPCR primer pairs and template standards for NR4A1
    OriGene qSTAR qPCR primer pairs in human, mouse for NR4A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR4A1
      QuantiTect SYBR Green Assays in human, mouse, rat NR4A1
      QuantiFast Probe-based Assays in human, mouse, rat NR4A1

    Additional mRNA sequence: 

    AB307717.1 AK075054.1 AK075491.1 AK131566.1 AK297526.1 BC016147.1 BT007144.1 CR456704.1 
    D49728.1 HQ692855.1 L13740.1 

    21 DOTS entries:

    DT.99933453  DT.455683  DT.100835625  DT.95197080  DT.86851887  DT.95211685  DT.100677763  DT.95211671 
    DT.121120228  DT.92017879  DT.100835629  DT.97764057  DT.100835628  DT.100835633  DT.97766106  DT.100835623 
    DT.100835626  DT.121120232  DT.121120237  DT.121120260  DT.95211694 

    Selected AceView cDNA sequences (see all 423):

    BQ877255 AA582312 BF847963 BQ636118 AV749319 BF915025 AI270652 CA397308 
    AV709909 BQ722446 BQ217551 AK131566 CK429599 AW006682 BM998346 BQ716170 
    BF725615 CK823444 AV701978 CB266198 BQ004741 AL541415 BQ029547 BX280956 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NR4A1 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ·
    SP1:                                                                                                                    -     -                                 
    SP2:                                            -     -     -     -     -     -     -     -     -     -                 -     -                                 
    SP3:                                                                                                                    -     -           -     -               
    SP4:                                            -     -                                                                                                         
    SP5:                                            -                                                                                                               

    ExUns: 13c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NR4A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NR4A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAAATACA
    NR4A1 Expression
    About this image


    NR4A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Ovary (Reproductive System)
             Mature Granulosa Cells Antral Follicle
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    NR4A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR4A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524430

    UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
    Tissue specificity: Fetal muscle and adult liver, brain and thyroid

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR4A1: 
              T Helper Cell Differentiation in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Apoptosis 384HT in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NR4A1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr4a11 , 5 nuclear receptor subfamily 4, group A, member 11, 5 86.01(n)1
    91.14(a)1
      15 (56.64 cM)5
    153701  NM_010444.21  NP_034574.11 
     1012668465 
    lizard
    (Anolis carolinensis)
    Reptilia NR4A16
    nuclear receptor subfamily 4, group A, member 1
    70(a)
    1 ↔ 1
    2(92812476-92825914)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056025.12   -- 76.87(n)    BC056025.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr4a11 nuclear receptor subfamily 4, group A, member 1 61.3(n)
    60.18(a)
      431720  NM_001002173.1  NP_001002173.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hr383 epidermal differentiation
    ligand-dependent nuclear more
    64(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-66
    Protein NHR-6, isoform a
    25(a)
    1 → many
    III(3573585-3578772) WBGene00003605


    ENSEMBL Gene Tree for NR4A1 (if available)
    TreeFam Gene Tree for NR4A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NR4A1 gene
    NR4A32  ESRRA2  NR3C22  PGR2  ESR22  NR3C12  AR2  NR4A22  
    ESRRB2  ESR12  ESRRG2  
    Selected SIMAP similar genes for NR4A1 using alignment to 8 protein entries:     NR4A1_HUMAN (see all proteins) (see all similar genes):
    DKFZp451G125    HNF4G    VDR    DKFZp779O0162    ESR1    HNF4alpha
    NR1I3    NR4A2    NR3C2    NR5A1    NR4A3    RXRB
    NR2B1    RXRA    NR1B3    RARG    NR1B2    NR2B3

    Find genes that share paralogs with NR4A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NR4A1 (see all 794)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681745251,2
    C--49479285(+) ATCAC-/GTGT  
            
    GTGTG
    3 -- int10--------
    rs1867169771,2
    --52414719(+) TGGTGA/GGGAGC 1 -- us2k10--------
    rs26037471,2
    C,F--52414782(+) ACCATT/CGGGAG 1 -- us2k12Minor allele frequency- C:0.09CSA WA 120
    rs1905410301,2
    --52414829(+) CCTTCC/TTCAGC 1 -- us2k10--------
    rs1405129331,2
    --52414904(+) AGACAA/CCCTCC 1 -- us2k10--------
    rs1824290931,2
    --52415422(+) CTGCTC/TCCCTA 1 -- us2k10--------
    rs1442496861,2
    --52415447(+) CTTTAC/GTGACT 1 -- us2k10--------
    rs111699841,2
    A--52415753(+) TTTGGG/TTTTTG 1 -- us2k10--------
    rs73095471,2
    C,F,A--52415758(+) TTTTTG/TAAACA 1 -- us2k15Minor allele frequency- T:0.30NA WA EA 362
    rs619140471,2
    C,F--52415759(+) TTTTGC/AAACAG 1 -- us2k11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for NR4A1 (52416616 - 52453291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NR4A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656525CNV Deletion23128226
    dgv1425n71CNV Loss21882294
    nsv899082CNV Loss21882294
    nsv832409CNV Loss17160897
    dgv1424n71CNV Loss21882294
    nsv899079CNV Loss21882294
    nsv518451CNV Loss19592680
    nsv469378CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR4A1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 139139    OMIM disorders: --

    2 diseases for NR4A1:    
    About MalaCards
    staphyloenterotoxemia    impetigo

    3 diseases from the University of Copenhagen DISEASES database for NR4A1:
    Mucoepidermoid carcinoma     Staphyloenterotoxemia     Impetigo

    Find genes that share disorders with NR4A1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NR4A1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudohypoaldosteronism 67 2 9141514 (1), 12788847 (1)
    mammary tumor 39 3 1648951 (1), 14500761 (1), 8070376 (1)
    carcinoma adrenocortical 29.1 1 15292355 (1)
    leukemogenesis 22.7 1 19148494 (1)
    gastric cancer 16.1 10 12376465 (4), 14592536 (2), 15601544 (2), 15494375 (1) (see all 5)
    choriocarcinoma 6.34 1 8119938 (1)
    leukemia t-cell 3.86 1 10772826 (1)
    parkinson disease 2.31 4 20096738 (1), 15956351 (1), 19635563 (1)
    burkitt lymphoma 1.13 1 7589118 (1)
    ischemia 0 2 14715474 (1), 8964794 (1)

    Genetic Association Database (GAD): NR4A1
    Human Genome Epidemiology (HuGE) Navigator: NR4A1 (4 documents)

    Export disorders for NR4A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NR4A1 gene, integrated from 10 sources (see all 398):
    (articles sorted by number of sources associating them with NR4A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. (PubMed id 2626032)1, 2, 3 Chang C.... Chang Y. (J. Steroid Biochem. 1989)
    2. Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia. (PubMed id 20010315)1, 4, 9 Novak G....Le Foll B. (Psychiatr. Genet. 2010)
    3. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. (PubMed id 15466594)1, 2, 9 Harant H. and Lindley I.J. (Nucleic Acids Res. 2004)
    4. A human early response gene homologous to murine nur77 and rat NGFI- B, and related to the nuclear receptor superfamily. (PubMed id 2283997)1, 2, 9 Nakai A.... Degroot L.J. (Mol. Endocrinol. 1990)
    5. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. (PubMed id 22983157)1, 2 Zhan Y.Y....Wu Q. (Nat. Chem. Biol. 2012)
    6. No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes. (PubMed id 20525362)1, 4 MA1ssig K....Staiger H. (BMC Med. Genet. 2010)
    7. Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1. (PubMed id 20438716)1, 2 Kang S.A....Lee M.O. (Biochem. Pharmacol. 2010)
    8. Replicated association of the NR4A3 gene with smoking behaviour in schizophrenia and in bipolar disorder. (PubMed id 20659174)1, 4 Novak G....Le Foll B. (Genes Brain Behav. 2010)
    9. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    10. CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. (PubMed id 15459248)1, 2 Park K.C....Shong M. (Mol. Endocrinol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3164 HGNC: 7980 AceView: NR4A1 Ensembl:ENSG00000123358 euGenes: HUgn3164
    ECgene: NR4A1 Kegg: 3164 H-InvDB: NR4A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NR4A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NR4A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NR4A1 gene:
    Search GeneIP for patents involving NR4A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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