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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR4A1 Gene

protein-coding   GIFtS: 65
GCID: GC12P052416

nuclear receptor subfamily 4, group A, member 1


(Previous symbols: HMR, GFRP1)
 Explore 53 diseases affiliated with
NR4A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NR4A1    

Aliases
for NR4A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Receptor Subfamily 4, Group A, Member 11 2     Testicular Receptor 32 3
GFRP11 2 3 5     ST-592 3
HMR1 2 3 5     NP102 5
N101 2     Growth Factor-Inducible Nuclear Protein N102
NAK-11 2     Hormone Receptor2
NGFIB1 2     Nerve Growth Factor IB Nuclear Receptor Variant 12
NUR771 2     Nuclear Receptor Subfamily 4 Group A Member 12
TR31 2     Steroid Receptor TR32
Early Response Protein NAK12 3     TR3 Orphan Receptor2
Nuclear Hormone Receptor NUR/772 3     NAK13
Orphan Nuclear Receptor HMR2 3     Nur773
Orphan Nuclear Receptor TR32 3     

External Ids:    HGNC: 79801   Entrez Gene: 31642   Ensembl: ENSG000001233587   OMIM: 1391395   UniProtKB: P227363   

Export aliases for NR4A1 gene to outside databases

Previous GC identifers: GC12M052494 GC12P052474 GC12P052154 GC12P050723 GC12P050717 GC12P052432 GC12P049478


Summaries
for NR4A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NR4A1:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by
phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as
a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes
during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit
NF-kappa-B transactivation of IL2

Gene Wiki entry for NR4A1 (Nerve Growth factor IB)


Genomic Views
for NR4A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR4A1 gene promoter:
         SRF   CREB   Max1   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR4A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR4A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR4A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

NR4A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR4A1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P052416:  view genomic region     (about GC identifiers)

Start:
 52,416,616 bp from pter      End:
 52,453,291 bp from pter
Size:
 36,676 bases      Orientation:
 plus strand

Proteins
for NR4A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 4 group A member 1  
Size: 598 amino acids; 64463 Da
Subunit: Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1
Subcellular location: Nucleus
3 PDB 3D structures from and Proteopedia for NR4A1:
2QW4 (3D)        3V3E (3D)        3V3Q (3D)    
Secondary accessions: B4DML7
Alternative splicing: 2 isoforms:  P22736-1   P22736-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NR4A1: NX_P22736

Post-translational modifications:

  • Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22736

    • NR4A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001189162.1  NP_002126.2  NP_775180.1  

    ENSEMBL proteins: 
     ENSP00000456633   ENSP00000457070   ENSP00000456776   ENSP00000440864   ENSP00000449539  
     ENSP00000449858   ENSP00000378301   ENSP00000449587   ENSP00000455399   ENSP00000455767  
     ENSP00000353427   ENSP00000243050   ENSP00000378302  
    Reactome Protein details: P22736
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): NR4A1
    OriGene Custom Protein Services for NR4A1 
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    Novus Biologicals NR4A1 Proteins
    Novus Biologicals NR4A1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NR4A1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--


    NR4A1 for ontologies           About GeneDecksing



    NR4A1 Antibody Products: 
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    ThermoFisher Antibodies for NR4A1

    Assay Products for NR4A1: 
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    Uscn ELISAs and CLIAs for NR4A1

    Protein Domains /
    Families
    for NR4A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NR4A1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P22736

    ProtoNet protein and cluster: P22736

    3 Blocks protein families:
    IPB001723 Steroid hormone receptor signature
    IPB003070 Orphan nuclear receptor (4A nuclear receptor) family signature
    IPB003071 Orphan nuclear receptor HMR signature


    UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
    Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Function
    for NR4A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
    Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes
    during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit
    NF-kappa-B transactivation of IL2
    Induction: By growth-stimulating agents

         Genatlas biochemistry entry for NR4A1:
    nuclear receptor subfamily 4,group A,member 1,steroid/thyroid receptor superfamily,likely functionning as a general
    coactivation of gene transcription

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NR4A1 (see all 14):
    hsa-miR-224 hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-4272 hsa-miR-605 hsa-miR-3120-3p hsa-miR-656 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: NR4A1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR4A1 (see all 7)
    OriGene shRNA RFP: NR4A1
    OriGene siRNA: NR4A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR4A1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NR4A1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR4A1 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): NR4A1 (NM_002135)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR4A1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NR4A1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR4A1

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ISS--
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI--


    NR4A1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nr4a1tm1Jmi for NR4A1
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nr4a1):
     behavior/neurological  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     integument  liver/biliary system  mortality/aging  tumorigenesis 

    NR4A1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NR4A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PIP3 activates AKT signaling1.00
    		PI3K/AKT activation0.97
    		PI3K/AKT Signaling in Cancer1.00
    		GAB1 signalosome0.96
    		PI3K events in ERBB2 signaling1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB4 signaling1.00
    		Signaling by SCF-KIT0.72
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    4Immune response_Function of MEF2 in T lymphocytes
    		Immune response_Function of MEF2 in T lymphocytes1.00
    		Immune response Function of MEF2 in T lymphocytes0.90
    5Signal transduction_Activation of PKC via G-Protein coupled receptor
    		Signal transduction_Activation of PKC via G-Protein coupled receptor1.00
    		Signal transduction Activation of PKC via G-Protein coupled receptor0.98

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for NR4A1
        Immune response Function of MEF2 in T lymphocytes
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NR4A1
        NK1R-mediated Non-Apoptotic PCD
    Nur77-Induced AICD in Macrophage
    Calcium Mediated T-Cell Apoptosis
    Nur77 Signaling in T-Cell
    CRHR Pathway

    3 Cell Signaling Technology (CST) Pathways for NR4A1
        Apoptosis and Autophagy
    Lymphocyte Signaling
    PI3K / Akt Signaling

    2 GeneGo (Thomson Reuters) Pathways for NR4A1
        Signal transduction Activation of PKC via G-Protein coupled receptor
    Immune response Function of MEF2 in T lymphocytes

    5 BioSystems Pathways for NR4A1 
        Nuclear Receptors
    MAPK signaling pathway
    Role of Calcineurin-dependent NFAT signaling in lymphocytes
    Glucocorticoid receptor regulatory network
    RXR and RAR heterodimerization with other nuclear receptor

    5/33        Reactome Pathways for NR4A1 (see all 33)
        Nuclear Receptor transcription pathway
    Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF


    1         Kegg Pathway  (Kegg details for NR4A1):
        MAPK signaling pathway


    NR4A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR4A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/163 Interacting proteins for NR4A1 (P227361, 2, 3 ENSP000002430504) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-4049673 MINT-4049732 MINT-4049598 MINT-4049689 MINT-4049708 MINT-4049650 I2D: score=3 STRING: ENSP00000269305
    BCL2P104151, 3, ENSP000003296234EBI-721550,EBI-77694 I2D: score=4 STRING: ENSP00000329623
    ATXN1P542532, 3, ENSP000002447694MINT-2859701 I2D: score=3 STRING: ENSP00000244769
    PRDX4Q131622, 3, ENSP000003686464MINT-8264116 I2D: score=2 STRING: ENSP00000368646
    BBS10Q8TAM12, 3MINT-8263984 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IMP18059339
    GO:0002042cell migration involved in sprouting angiogenesis IDA18059339
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006915apoptotic process ----
    GO:0006917induction of apoptosis IEA--


    NR4A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NR4A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NR4A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR4A1
    10/55 Novoseek chemical compound relationships for NR4A1 gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nor 1 92.5 26 10773199 (4), 17096060 (3), 18945812 (2), 15947483 (2) (see all 14)
    ru 26752 84 3 8639467 (2)
    18-vinylprogesterone 81.5 2 7588320 (1), 8068005 (1)
    cd 437 69.8 9 9671482 (4), 16434970 (2), 17150035 (2)
    steroid 62.5 45 1922099 (3), 1655735 (1), 7849260 (1), 15128284 (1) (see all 35)
    retinoid 56.3 13 12082103 (1), 15494375 (1), 10772826 (1), 7705655 (1) (see all 10)
    retinoic acid 48.4 47 14592536 (5), 10772826 (5), 15494375 (4), 9130711 (3) (see all 12)
    forskolin 43.8 14 15615861 (3), 16002533 (3), 15128284 (1), 11174853 (1) (see all 6)
    spironolactone 42.4 1 8068005 (1)
    acth 39.7 20 9322922 (6), 9592111 (3), 10340952 (2), 9496246 (2) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about NR4A1 

    Transcripts
    for NR4A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NR4A1 gene (5 alternative transcripts): 
    NM_001202233.1  NM_002135.4  NM_173157.2  NM_001202234.1  NM_173158.1  

    Unigene Clusters for NR4A1:

    Nuclear receptor subfamily 4, group A, member 1
    Hs.524430  [show with all ESTs], Hs.670088  [show with all ESTs]
    Unigene Representative Sequences: AK131566, D85245
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000548977 ENST00000546842 ENST00000553200 ENST00000545748(uc010sno.2)
    ENST00000550082 ENST00000549102 ENST00000478250(uc001rzr.2 uc009zmb.2)
    ENST00000547206 ENST00000550763 ENST00000394824(uc009zmc.3) ENST00000550525
    ENST00000548232 ENST00000562373 ENST00000548733 ENST00000550557 ENST00000564201
    ENST00000550339 ENST00000567890

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NR4A1 (see all 14):
    hsa-miR-224 hsa-miR-16-2* hsa-miR-520d-5p hsa-miR-4272 hsa-miR-605 hsa-miR-3120-3p hsa-miR-656 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: NR4A1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR4A1 (see all 7)
    OriGene shRNA RFP: NR4A1
    OriGene siRNA: NR4A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR4A1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): NR4A1 (NM_002135)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR4A1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR4A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR4A1

    Additional cDNA sequence: 

    AK314437.1 D85245.1 

    24/29 DOTS entries (see all 29):

    DT.100835625  DT.95211685  DT.99933453  DT.455683  DT.100677763  DT.95197080  DT.86851887  DT.95211694 
    DT.121120228  DT.95211671  DT.121120236  DT.121120215  DT.92443432  DT.91754839  DT.92017879  DT.100835627 
    DT.100835629  DT.121120237  DT.97762198  DT.97764057  DT.97819747  DT.100835623  DT.100835626  DT.100835628 

    24/423 AceView cDNA sequences (see all 423):

    AL047948 AL047492 AI362414 BX280917 BQ893911 BF725615 AL047238 BQ722446 
    AW328183 CA405635 BQ636118 BQ217551 T28725 BF437220 CD245324 NM_173157 
    BQ716170 NM_002135 BQ898376 CB270633 BM998346 BQ772051 BQ004741 BE326874 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NR4A1 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ·
    SP1:                                                                                                                    -     -                                 
    SP2:                                            -     -     -     -     -     -     -     -     -     -                 -     -                                 
    SP3:                                                                                                                    -     -           -     -               
    SP4:                                            -     -                                                                                                         
    SP5:                                            -                                                                                                               

    ExUns: 13c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NR4A1

    Expression
    for NR4A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR4A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAAATACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NR4A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMature Granulosa CellsOvary
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NR4A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR4A1

    SOURCE GeneReport for Unigene clusters: Hs.524430 Hs.670088

    UniProtKB/Swiss-Prot: NR4A1_HUMAN, P22736
    Tissue specificity: Fetal muscle and adult liver, brain and thyroid

        SABiosciences Expression via Pathway-Focused PCR Arrays including NR4A1: 
              T Helper Cell Differentiation in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat
              Apoptosis 384HT in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for NR4A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NR4A1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia NR4A16
    		 --
    		 69(a)
    		 1 ↔ 1
    		 2(92812439-92823211)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC056025.12   -- 76.87(n)    BC056025.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nr4a11 nuclear receptor subfamily 4, group A, member 1 62.65(n)
    61.77(a)    		   431720  NM_001002173.1  NP_001002173.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hr383 epidermal differentiation ligand-dependent
    nuclear more    		 64(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea nhr-61 Protein NHR-6 45.67(n)
    36.78(a)    		   175462  NM_065330.4  NP_497731.1 


    ENSEMBL Gene Tree for NR4A1 (if available)
    TreeFam Gene Tree for NR4A1 (if available) 

    Paralogs
    for NR4A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR4A1 gene
    VDR2  NR4A32  NR1I22  RARG2  NR1I32  THRB2  RARA2  NR1H22  
    NR4A22  NR1H42  RARB2  THRA2  NR1H32  
    18/24 SIMAP similar genes for NR4A1 using alignment to 11 protein entries:     NR4A1_HUMAN (see all proteins) (see all similar genes):
    DKFZp451G125    HNF4G    VDR    ESR1    DKFZp779O0162    HNF4alpha
    NR1I3    NR4A2    NR3C2    NR5A1    NR4A3    RXRB
    NR2B1    RXRA    NR1B3    RARG    NR1B2    NR2B3

    NR4A1 for paralogs           About GeneDecksing



    Genomic Variants
    for NR4A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/628 NCBI SNPs in NR4A1 are shown (see all 628)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1867169771,2
    		--52414719(+) TGGTGA/GGGAGC 1 -- us2k10--------
    rs26037471,2
    		--52414782(+) ACCATT/CGGGAG 1 -- us2k12Minor allele frequency- C:0.09CSA WA 120
    rs1905410301,2
    		--52414829(+) CCTTCC/TTCAGC 1 -- us2k10--------
    rs1405129331,2
    		--52414904(+) AGACAA/CCCTCC 1 -- us2k10--------
    rs1824290931,2
    		--52415422(+) CTGCTC/TCCCTA 1 -- us2k10--------
    rs1442496861,2
    		--52415447(+) CTTTAC/GTGACT 1 -- us2k10--------
    rs111699841,2
    		A--52415753(+) TTTGGG/TTTTTG 1 -- us2k10--------
    rs73095471,2
    		C,F,A,--52415758(+) TTTTTG/TAAACA 1 -- us2k15Minor allele frequency- T:0.30NA WA EA 362
    rs619140471,2
    		--52415759(+) TTTTGC/AAACAG 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1453267981,2
    		--52416047(+) CTCAA-/AAAAAG
                AAAAA     		1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NR4A1 (52416616 - 52453291 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NR4A1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NR4A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NR4A1 for disorders           About GeneDecksing

    OMIM gene information: 139139    OMIM disorders: --

    20/53 diseases for NR4A1 (see all 53):    About MalaCards
    maturity-onset diabetes of the young    thyroiditis    tardive dyskinesia    pseudohypoaldosteronism
    burkitt's lymphoma    staphyloenterotoxemia    impetigo    atopic dermatitis
    brain injury    acute lymphoblastic leukemia    rheumatoid arthritis    lymphoblastic leukemia
    acute myeloid leukemia    myeloid leukemia    cutaneous t cell lymphoma    parkinson's disease
    renal cell carcinoma    choriocarcinoma    bipolar disorder    stomach cancer

    2 diseases from the University of Copenhagen DISEASES database for NR4A1:
    Staphyloenterotoxemia     Impetigo

    10/24 Novoseek disease relationships for NR4A1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudohypoaldosteronism 67 2 9141514 (1), 12788847 (1)
    mammary tumor 39 3 1648951 (1), 14500761 (1), 8070376 (1)
    carcinoma adrenocortical 29.1 1 15292355 (1)
    leukemogenesis 22.7 1 19148494 (1)
    gastric cancer 16.1 10 12376465 (4), 14592536 (2), 15601544 (2), 15494375 (1) (see all 5)
    choriocarcinoma 6.34 1 8119938 (1)
    leukemia t-cell 3.86 1 10772826 (1)
    parkinson disease 2.31 4 20096738 (1), 15956351 (1), 19635563 (1)
    burkitt lymphoma 1.13 1 7589118 (1)
    ischemia 0 2 14715474 (1), 8964794 (1)

    Human Genome Epidemiology (HuGE) Navigator: NR4A1 (4 documents)

    Export disorders for NR4A1 gene to outside databases

    Publications
    for NR4A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR4A1 gene, integrated from 9 sources (see all 382):
    (articles sorted by number of sources associating them with NR4A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. (PubMed id 2626032)1, 2, 3 Chang C.... Chang Y. (1989)
    2. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. (PubMed id 15466594)1, 2, 9 Harant H. and Lindley I.J. (2004)
    3. A human early response gene homologous to murine nur77 and rat NGFI- B, and related to the nuclear receptor superfamily. (PubMed id 2283997)1, 2, 9 Nakai A.... Degroot L.J. (1990)
    4. CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. (PubMed id 15459248)1, 2 Park K.C....Shong M. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Phorbol ester, forskolin, and serum induction of a human colon nuclear hormone receptor gene related to the NUR 77/NGFI-B genes. (PubMed id 1651101)1, 2 Bondy G.P. (1991)
    8. Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung cancer cells. (PubMed id 14612408)1, 9 Kolluri S.K....Zhang X.K. (2003)
    9. Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells. (PubMed id 12376465)1, 9 Wu Q....Su W.J. (2002)
    10. Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. (PubMed id 16434970)1, 9 Han Y.H....Zhang X.K. (2006)

    External Searches for NR4A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NR4A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3164 HGNC: 7980 AceView: NR4A1 Ensembl:ENSG00000123358 euGenes: HUgn3164
    ECgene: NR4A1 Kegg: 3164 H-InvDB: NR4A1

    Other Databases showing NR4A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NR4A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR4A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NR4A1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NR4A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NR4A1 gene:
    Search GeneIP for patents involving NR4A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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