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NR3C1 Gene

protein-coding   GIFtS: 74
GCID: GC05M142639

Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid...

(Previous names: nuclear receptor subfamily 3, group C, member 1)
(Previous symbol: GRL)
  See NR3C1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid
Receptor)1 2
     GCCR2
GRL1 2 3 5     Glucocorticoid Nuclear Receptor Variant 12
GR2 3     Glucocorticoid Receptor2
GCR2 5     Nuclear Receptor Subfamily 3 Group C Member 13
Nuclear Receptor Subfamily 3, Group C, Member 11     

External Ids:    HGNC: 79781   Entrez Gene: 29082   Ensembl: ENSG000001135807   OMIM: 1380405   UniProtKB: P041503   

Export aliases for NR3C1 gene to outside databases

Previous GC identifers: GC05M142559 GC05M143241 GC05M142687 GC05M137804


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NR3C1 Gene:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to
glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their
transcription, and as a regulator of other transcription factors. This receptor is typically found in the
cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses,
cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with
generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding
either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame
translation initiation sites have also been described, and shown to be functional, displaying diverse
cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). (provided by
RefSeq, Feb 2011)

GeneCards Summary for NR3C1 Gene:
NR3C1 (nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)) is a protein-coding gene. Diseases associated with NR3C1 include primary cortisol resistance, and cortisol resistance. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NR4A3.

UniProtKB/Swiss-Prot: GCR_HUMAN, P04150
Function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to
glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other
transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target
tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and
could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May
play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression

summary for NR3C1 Gene:
Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes
mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB
proteins, which are shed upon activation. The major signaling pathway used by GRs is via direct DNA binding
and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly
with transcription factors such as NF-kappaB, AP-1 or STAT. GRs are ubiquitously expressed and mediate a
vast array of physiological functions. Glucocorticoids regulate carbohydrate, protein and fat metabolism,
modulate immune responses through supression of chemokine and cytokine production and have critical roles in
constitutive activity of the CNS, digestive, hematopoietic, renal and reproductive systems. The human gene
encoding the glucocorticoid receptor has been localized to 5q31-q32.

Gene Wiki entry for NR3C1 (Glucocorticoid receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR3C1 gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR3C1 promoter sequence
   Search Chromatin IP Primers for NR3C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR3C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31-q32

NR3C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR3C1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M142639:  view genomic region     (about GC identifiers)

Start:
142,657,496 bp from pter      End:
142,815,077 bp from pter
Size:
157,582 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GCR_HUMAN, P04150 (See protein sequence)
Recommended Name: Glucocorticoid receptor  
Size: 777 amino acids; 85659 Da
Subunit: Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such
as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and
FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the
complex dissociates. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2
or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1,
POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300,
TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits
transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1,
SMARCD1, and SMARCE1
Miscellaneous: High constitutive expression of isoform Beta by neutrophils may provide a mechanism by which these
cells escape glucocorticoid-induced cell death. Up-regulation by proinflammatory cytokines such as IL8 further
enhances their survival in the presence of glucocorticoids during inflammation
Miscellaneous: Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine
polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear
localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this
receptor, a well-characterized transcriptional regulator
Selected PDB 3D structures from and Proteopedia for NR3C1 (see all 12):
1M2Z (3D)        1NHZ (3D)        1P93 (3D)        3BQD (3D)        3CLD (3D)        3E7C (3D)    
Secondary accessions: A0ZXF9 B0LPG8 D3DQF4 P04151 Q53EP5 Q6N0A4
Alternative splicing, Alternative initiation: 10 isoforms:  P04150-1   P04150-2   P04150-3   P04150-6   P04150-5   P04150-7   P04150-4   P04150-8   
P04150-9   P04150-10   (Produced by alternative initiation at Met-27 of isoform Beta)

Explore the universe of human proteins at neXtProt for NR3C1: NX_P04150

Explore proteomics data for NR3C1 at MOPED

Post-translational modifications: 

  • Increased proteasome-mediated degradation in response to glucocorticoids1
  • Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The
    Ser-203-phosphorylated form is mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear.
    Transcriptional activity correlates with the amount of phosphorylation at Ser-211. May be dephosphorylated by
    PPP5C, attenuates NR3C1 action1
  • Sumoylated; this reduces transcription transactivation1
  • Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity)1
  • Ubiquitination2 at Lys419
  • Modification sites at PhosphoSitePlus

  • See NR3C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (15 alternative transcripts): 
    NP_000167.1  NP_001018084.1  NP_001018085.1  NP_001018086.1  NP_001018087.1  NP_001018661.1  NP_001019265.1  NP_001191187.1  
    NP_001191188.1  NP_001191189.1  NP_001191190.1  NP_001191191.1  NP_001191192.1  NP_001191193.1  NP_001191194.1  

    ENSEMBL proteins: 
     ENSP00000377977   ENSP00000387672   ENSP00000422518   ENSP00000377979   ENSP00000231509  
     ENSP00000427672   ENSP00000424747   ENSP00000425313   ENSP00000420856   ENSP00000426478  
     ENSP00000425374   ENSP00000343205   ENSP00000405282   ENSP00000404218  
    Reactome Protein details: P04150

    NR3C1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NR3C1
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    Novus Biologicals NR3C1 Proteins
    Novus Biologicals NR3C1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NR3C1

     
    Search eBioscience for Proteins for NR3C1 

    NR3C1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NR3C1
    R&D Systems Antibodies for NR3C1 (GR/NR3C1)
    Cell Signaling Technology (CST) Antibodies for NR3C1  (GR)
    OriGene Antibodies for NR3C1
    OriGene Custom Antibody Services for NR3C1
    Novus Biologicals NR3C1 Antibodies
    Abcam antibodies for NR3C1
    Cloud-Clone Corp. Antibodies for NR3C1
    ThermoFisher Antibody for NR3C1
    LSBio Antibodies in human, mouse, rat for NR3C1

    NR3C1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NR3C1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NR3C1
    Cloud-Clone Corp. CLIAs for NR3C1
    Search eBioscience for ELISAs for NR3C1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucocorticoid receptor
    3C. 3-Ketosteroid receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P04150

    ProtoNet protein and cluster: P04150

    2 Blocks protein domains:
    IPB001409 Glucocorticoid receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: GCR_HUMAN, P04150
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with NR3C1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCR_HUMAN, P04150
    Function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to
    glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other
    transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target
    tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and
    could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May
    play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression

         Genatlas biochemistry entry for NR3C1:
    nuclear recptor subafamily 3,group C,member 1,steroid/thyroid hormone receptor superfamily,interacting with
    tissue-specific transcriptional activators required for receptor actin (see HNFS)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003707steroid hormone receptor activity ----
    GO:0004883glucocorticoid receptor activity IEA--
    GO:0005496steroid binding IEA--
         
    Find genes that share ontologies with NR3C1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NR3C1:
     Decreased viability  Increased cell death HMECs cel 

         Selected MGI mutant phenotypes (inferred from 13 alleles(MGI details for Nr3c1) (see all 21):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with NR3C1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NR3C1: Nr3c1tm1Ljm Nr3c1tm1Gsc Nr3c1tm2.1Gsc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR3C1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NR3C1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR3C1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR3C1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NR3C1 (see all 1325):
    A2M,  ABCA10,  ABCA8,  ABCC3,  ABCC4,  ABCC6,  ABCC8,  ABCC9,  ABCD2,  ABCG4

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NAGAACAGNCTGTTCT 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NR3C1:
    hsa-mir-421 (MIRT039437), hsa-mir-124-3p (MIRT004546), hsa-mir-155-5p (MIRT020725), hsa-mir-32-5p (MIRT028300), hsa-mir-590-3p (MIRT016193), hsa-mir-19b-3p (MIRT031124), hsa-mir-18a-5p (MIRT004545), hsa-mir-130b-3p (MIRT020164), hsa-mir-22-3p (MIRT030650)

    Block miRNA regulation of human, mouse, rat NR3C1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR3C1 (see all 161):
    hsa-miR-411* hsa-miR-199a-3p hsa-miR-1273d hsa-miR-376a* hsa-miR-642b hsa-miR-200b hsa-miR-200c* hsa-miR-147
    SwitchGear 3'UTR luciferase reporter plasmidNR3C1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NR3C1
    Predesigned siRNA for gene silencing in human, mouse, rat NR3C1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NR3C1

    Clone
    Products:
         
    OriGene clones in human, mouse for NR3C1 (see all 39)
    OriGene ORF clones in mouse, rat for NR3C1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 15): NR3C1 (NM_001024094)
    Sino Biological Human cDNA Clone for NR3C1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR3C1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR3C1
    Addgene plasmids for NR3C1 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR3C1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12364) for NR3C1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GCR_HUMAN, P04150: Cytoplasm. Mitochondrion. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after
    ligand-binding
    GCR_HUMAN, P04150: Isoform Beta: Nucleus. Note=Localized largely in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol3
    cytoskeleton2
    extracellular2
    peroxisome2
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with NR3C1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NR3C1 About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66
    3PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    Glucocorticoid Receptor Signaling0.43
    4Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    5Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics


    Find genes that share SuperPaths with NR3C1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NR3C1
        TGF-beta Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NR3C1
        Glucocorticoid Receptor Signaling
    NTHi-Induced Signaling
    Prolactin Signaling
    MIF Mediated Glucocorticoid Regulation

    Selected GeneGo (Thomson Reuters) Pathways for NR3C1 (see all 7)
        Immune response IL-6 signaling pathway
    Immune response MIF-mediated glucocorticoid regulation
    Development Prolactin receptor signaling
    Proteolysis Putative SUMO-1 pathway
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    Selected BioSystems Pathways for NR3C1 (see all 9)
        Adipogenesis
    Nuclear Receptors
    Serotonin Receptor 4/6/7 and NR3C Signaling
    SIDS Susceptibility Pathways
    Regulation of Androgen receptor activity


    2 Reactome Pathways for NR3C1
        Nuclear Receptor transcription pathway
    BMAL1:CLOCK,NPAS2 activates circadian gene expression

    2 PharmGKB Pathways for NR3C1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for NR3C1):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR3C1 (see all 10): 
              Nuclear Receptors & Coregulators in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR3C1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NR3C1 (P041501, 2, 3 ENSP000002315094) via UniProtKB, MINT, STRING, and/or I2D (see all 268)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=3 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=3 
    ENSG00000215328P081073I2D: score=3 
    ENSG00000224501P081073I2D: score=3 
    ENSG00000231555P081073I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006111regulation of gluconeogenesis IEA--
    GO:0006351transcription, DNA-templated TAS10887960
    GO:0006355regulation of transcription, DNA-templated IDA19141540
    GO:0006366transcription from RNA polymerase II promoter TAS8621628
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with NR3C1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NR3C1
      Browse compounds at ApexBio 

    Compounds for NR3C1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GSK 9027Glucocorticoid receptor agonist[1229096-88-1]
    Fluticasone propionateSelective high affinity glucocorticoid agonist[80474-14-2]
    HydrocortisoneAdrenal glucocorticoid; immunosuppressant[50-23-7]
    CorticosteroneEndogenous glucocorticoid[50-22-6]
    Mometasone furoateSynthetic corticosteroid; anti-inflammatory agent[83919-23-7]

    4 HMDB Compounds for NR3C1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-117602195
    Cortexolone11-Deoxy-17-hydroxycorticosterone (see all 21)152-58-93741883
    Deoxycorticosterone11-Dehydroxycorticosterone (see all 21)64-85-73741883
    Cortisol11-Hydrocortisone (see all 173)50-23-7--

    Selected DrugBank Compounds for NR3C1 (see all 40)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Amcinonide-- 51022-69-6targetagonist16895953 17139284 17016423 16980198 16891588 17086345 17038445
    Cortisone acetate-- 50-04-4targetagonist7062741 16895953 7054210 16980198 16891588 17086345 17038445
    Flunisolide-- 3385-03-3targetagonist2386110 15285788 8466638 11752352 11368283 9563368 9523318
    Budesonide-- 51333-22-3targetantagonist12920235 12601049 11258648 11730731 11752352 11040338
    Desoximetasone-- 382-67-2targetagonist16895953 10754457 16980198 16891588 17086345 17038445
    DexamethasoneDesametasone (see all 9)50-02-2targetagonist16956592 16835395 16971495 11752352 16891588 16963802
    FluorometholoneFluormetholon (see all 4)426-13-1targetagonist15684812 16895953 16980198 16891588 17086345 17038445
    Fluticasone Propionate-- 80474-14-2targetagonist7878687 11730731 10200007 10518812 11752352 8646863
    MegestrolMegestrol Acetate (see all 5)3562-63-8targetagonist9195366 18411198 9744490 6222739 2982481 15595341
    Paramethasone-- 53-33-8targetagonist16895953 16980198 16891588 17086345 16255837 17038445

    Selected IUPHAR Ligands for NR3C1 (Glucocorticoid receptor) (see all 11)    About this table
    LigandTypeActionAffinityPubmed IDs
    mifepristone
    AntagonistAntagonist9.48282004 3560943
    dexamethasone
    AgonistAgonist8.1 - 98282004 10611474 10747884
    triamcinolone acetonide
    AgonistAgonist8.27472274 7583234
    cortisol
    AgonistAgonist7.3 - 88282004 10611474 10747884
    prednisolone
    AgonistAgonist7.810747884
    triamcinolone
    AgonistAgonist7.710747884
    deoxycorticosterone
    AgonistAgonist7.28282004 10747884
    RU28362
    AgonistAgonist7.2--
    [3H]dexamethasone
    AgonistAgonist7.2--
    onapristone
    AntagonistAntagonist7.2--

    Selected Novoseek inferred chemical compound relationships for NR3C1 gene (see all 120)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dexamethasone 91.8 1114 8574285 (4), 12781044 (4), 19167480 (4), 18657064 (4) (see all 99)
    mifepristone 91.4 396 19635558 (8), 17509631 (5), 12695529 (4), 14671179 (3) (see all 99)
    steroid 86 485 15155759 (4), 16890204 (4), 2168876 (3), 9731032 (3) (see all 99)
    11beta-hydroxysteroid 85.6 72 11836450 (3), 15866114 (2), 19048413 (2), 10588816 (1) (see all 52)
    cortisone 78.3 32 15062542 (2), 16178882 (2), 15780662 (1), 8200959 (1) (see all 21)
    cortivazol 76.6 24 11741935 (4), 2205477 (2), 15677712 (2), 2039752 (2) (see all 7)
    androstane 75.5 44 16399345 (2), 19541828 (2), 16188404 (2), 15933212 (2) (see all 24)
    progesterone 74.3 351 1920329 (4), 20156884 (4), 2249895 (3), 18060946 (3) (see all 99)
    corticosterone 72.2 114 2257242 (3), 17446698 (3), 12538030 (3), 10624831 (2) (see all 59)
    fluticasone propionate 69 48 15860753 (3), 10200007 (3), 9087160 (2), 12503693 (2) (see all 29)



    Find genes that share compounds with NR3C1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for NR3C1 gene (15 alternative transcripts): 
    NM_000176.2  NM_001018074.1  NM_001018075.1  NM_001018076.1  NM_001018077.1  NM_001020825.1  NM_001024094.1  NM_001204258.1  
    NM_001204259.1  NM_001204260.1  NM_001204261.1  NM_001204262.1  NM_001204263.1  NM_001204264.1  NM_001204265.1  

    Unigene Cluster for NR3C1:

    Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    Hs.122926  [show with all ESTs]
    Unigene Representative Sequence: NM_001018077
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394464(uc003lmy.3 uc003lmz.3 uc003lna.3 uc003lnb.3 uc011dbk.2)
    ENST00000415690 ENST00000504572 ENST00000394466(uc003lni.2) ENST00000231509(uc021yfb.1)
    ENST00000503201(uc021yfa.1 uc003lng.2) ENST00000504336 ENST00000510170
    ENST00000508760 ENST00000502892 ENST00000514699 ENST00000502500 ENST00000505058
    ENST00000503701 ENST00000343796(uc003lnc.3 uc003lnf.3 uc003lnd.3 uc003lne.3)
    ENST00000424646 ENST00000416954
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NR3C1 (see all 161):
    hsa-miR-411* hsa-miR-199a-3p hsa-miR-1273d hsa-miR-376a* hsa-miR-642b hsa-miR-200b hsa-miR-200c* hsa-miR-147
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    eBioscience FlowRNA Probe Sets ( VA1-12364) for NR3C1 

    Additional mRNA sequence: 

    AB307716.1 AJ877166.1 AJ877167.1 AJ877168.1 AJ877169.1 AJ877170.1 AJ877171.1 AJ877172.1 
    AJ888004.1 AK223594.1 AK302050.1 AK314789.1 AM183262.1 BC015610.2 BX640610.1 BX648553.1 
    HQ692822.1 JN797823.1 JN797824.1 U01351.1 U25029.1 X03225.1 X03348.1 

    23 DOTS entries:

    DT.100786784  DT.99998911  DT.85105550  DT.95296381  DT.95269160  DT.100786795  DT.100786792  DT.207488 
    DT.92441907  DT.102832223  DT.120796581  DT.40126589  DT.120796451  DT.120796608  DT.100786783  DT.100786785 
    DT.120796481  DT.218847  DT.100037621  DT.100737448  DT.100786786  DT.100786788  DT.120796605 

    Selected AceView cDNA sequences (see all 383):

    BQ433268 CA416785 BM468899 AA382009 AI636264 BU687895 BU076600 CB112400 
    AU135497 BQ007119 BQ049864 AU139241 BQ430272 CA425706 BQ061334 CA388845 
    BG545674 X03348 AW299567 BQ005253 BE739816 CA392568 BC015610 BQ693980 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NR3C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NR3C1 Expression
    About this image


    NR3C1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    NR3C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR3C1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122926

    UniProtKB/Swiss-Prot: GCR_HUMAN, P04150
    Tissue specificity: Widely expressed. In the heart, detected in left and right atria, left and right ventricles,
    aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR3C1 (see all 10): 
              Nuclear Receptors & Coregulators in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR3C1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NR3C1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr3c11 , 5 nuclear receptor subfamily 3, group C, member 11, 5 89.58(n)1
    90.7(a)1
      18 (21.09 cM)5
    148151  NM_008173.31  NP_032199.31 
     394105455 
    chicken
    (Gallus gallus)
    Aves NR3C11 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid more 74.04(n)
    75.55(a)
      416343  NM_001037826.1  NP_001032915.1 
    lizard
    (Anolis carolinensis)
    Reptilia NR3C16
    nuclear receptor subfamily 3, group C, member 1 (g...
    75(a)
    1 ↔ 1
    2(126275212-126336129)
    African clawed frog
    (Xenopus laevis)
    Amphibia xGR2 glucocorticoid receptor protein 76.06(n)    X72211.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CB362131.12   -- 72.79(n)    CB362131.1 


    ENSEMBL Gene Tree for NR3C1 (if available)
    TreeFam Gene Tree for NR3C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NR3C1 gene
    NR4A32  ESRRA2  NR3C22  NR4A12  PGR2  ESR22  AR2  NR4A22  
    ESRRB2  ESR12  ESRRG2  
    15 SIMAP similar genes for NR3C1 using alignment to 14 protein entries:     GCR_HUMAN (see all proteins):
    NR5A1    NR3C4    ESR1    VDR    NR1I3    HNF4G
    RORA    AR    PGR    HNF4alpha    NR3C2    ESRRB
    ESR2    PR    ESRRA

    Find genes that share paralogs with NR3C1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NR3C1
    PGOHUM00000249184


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    GCR_HUMAN, P04150: Carriers of the 22-Glu-Lys-23 allele are relatively more resistant to the effects of GCs with
    respect to the sensitivity of the adrenal feedback mechanism than non-carriers, resulting in a better metabolic
    health profile. Carriers have a better survival than non-carriers, as well as lower serum CRP levels. The
    22-Glu-Lys-23 polymorphism is associated with a sex-specific, beneficial body composition at young-adult age, as
    well as greater muscle strength in males


    Selected SNPs for NR3C1 (see all 3022)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0134724
    Glucocorticoid resistance (GCRES)4--see VAR_0134722 R H mis40--------
    VAR_0046774
    Glucocorticoid resistance (GCRES)4--see VAR_0046772 V I mis40--------
    VAR_0134734
    Glucocorticoid resistance (GCRES)4--see VAR_0134732 G S mis40--------
    VAR_0156314
    A glucocorticoid resistant leukemia cell line4--see VAR_0156312 C Y mis40--------
    VAR_0156324
    Glucocorticoid resistance (GCRES)4--see VAR_0156322 I N mis40--------
    VAR_0156334
    Glucocorticoid resistance (GCRES)4--see VAR_0156332 I M mis40--------
    VAR_0046784
    Two glucocorticoid resistant leukemia cell lines lacking the normal allele4--see VAR_0046782 L F mis40--------
    VAR_0046764
    Glucocorticoid resistance (GCRES)4--see VAR_0046762 D V mis40--------
    rs561499451,2
    C,Fnon-pathogenic1143055395(-) CGAAAA/G/TTTGGA 30 N S mis136MN NS NA WA EA CSA EU 12924
    rs1048939121,2
    Cpathogenic1142937543(-) ACTTCC/TGTTTC 27 P L mis1 int10--------

    HapMap Linkage Disequilibrium report for NR3C1 (142657496 - 142815077 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NR3C1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730857CNV Deletion23290073
    esv2730855CNV Deletion23290073
    esv1954637CNV Deletion18987734
    esv2730858CNV Deletion23290073
    esv1765773CNV Deletion17803354
    esv1001228CNV Deletion20482838
    esv2666615CNV Deletion23128226
    esv2730856CNV Deletion23290073
    esv1786342CNV Insertion17803354
    esv33748CNV Loss17666407

    Human Gene Mutation Database (HGMD): NR3C1
    Locus Specific Mutation Databases (LSDB): NR3C1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR3C1
    DNA2.0 Custom Variant and Variant Library Synthesis for NR3C1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138040    OMIM disorders: --

    UniProtKB/Swiss-Prot: GCR_HUMAN, P04150
  • Glucocorticoid resistance (GCRES) [MIM:138040]: Hypertensive, hyperandrogenic disorder characterized by
    increased serum cortisol concentrations. Inheritance is autosomal dominant. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 18 diseases for NR3C1:    
    About MalaCards
    primary cortisol resistance    cortisol resistance    glucocorticoid resistance    osteochondrosis
    ocular hypertension    corticosteroid-binding globulin deficiency    nelson syndrome    glucocorticoid-remediable aldosteronism
    treacher collins syndrome    pre-b-cell acute lymphoblastic leukemia    post-traumatic stress disorder    in situ carcinoma
    chronic fatigue syndrome    acth-secreting pituitary adenoma    dosage-sensitive sex reversal    primary pigmented nodular adrenocortical disease
    obesity    breast cancer

    6 diseases from the University of Copenhagen DISEASES database for NR3C1:
    Asthma     Cushing's syndrome     Hypertension     Diabetes mellitus
    Leukemia     Kidney disease

    Find genes that share disorders with NR3C1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NR3C1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cushing syndrome 69.7 17 10802524 (2), 1794941 (1), 16456492 (1), 16855182 (1) (see all 13)
    mammary tumor 63.9 36 1871124 (2), 10748103 (2), 2159467 (1), 8407999 (1) (see all 28)
    hypercortisolism 61.5 4 17587649 (1), 10995524 (1), 16118334 (1), 18406688 (1)
    hypercortisolemia 61.2 8 16546487 (1), 12399952 (1), 17037809 (1), 11131467 (1) (see all 5)
    asthma 55.9 137 18799869 (5), 9560836 (4), 18952539 (3), 9329880 (3) (see all 66)
    major depression 55.3 70 11274650 (5), 16019586 (4), 12727135 (3), 12242054 (2) (see all 36)
    acth syndrome ectopic 49.5 4 8396510 (1), 7958079 (1), 20015838 (1), 8254033 (1)
    shock 46.3 151 11463862 (8), 8745575 (5), 14673132 (4), 7917000 (3) (see all 69)
    nasal polyps 44.6 18 18671773 (3), 19848249 (2), 18396779 (2), 11800371 (2) (see all 9)
    inflammation 43.3 44 10435109 (2), 18821468 (2), 9482836 (1), 15541765 (1) (see all 32)

    Genetic Association Database (GAD): NR3C1
    Human Genome Epidemiology (HuGE) Navigator: NR3C1 (169 documents)

    Export disorders for NR3C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NR3C1 gene, integrated from 10 sources (see all 2447):
    (articles sorted by number of sources associating them with NR3C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study. (PubMed id 20371666)1, 4, 7, 9 Otte C....Whooley M.A. (J. Clin. Endocrinol. Metab. 2010)
    2. The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus. (PubMed id 11344238)1, 2, 4, 9 Dobson M.G.... Weaver J.U. (J. Clin. Endocrinol. Metab. 2001)
    3. Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene. (PubMed id 16895953)1, 4, 7 Rautanen A....Kajantie E. (J. Clin. Endocrinol. Metab. 2006)
    4. The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. (PubMed id 15292341)1, 2, 4 van Rossum E.F.C.... Lamberts S.W.J. (J. Clin. Endocrinol. Metab. 2004)
    5. Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. (PubMed id 15276593)1, 2, 4 van Rossum E.F.C.... Lamberts S.W.J. (Am. J. Med. 2004)
    6. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. (PubMed id 12351458)1, 2, 4 van Rossum E.F.C.... Lamberts S.W.J. (Diabetes 2002)
    7. Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance. (PubMed id 9150737)1, 2, 4 Koper J.W....Lamberts S.W.J. (Hum. Genet. 1997)
    8. Primary structure and expression of a functional human glucocorticoid receptor cDNA. (PubMed id 2867473)1, 2, 3 Hollenberg S.M.... Evans R.M. (Nature 1985)
    9. Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids. (PubMed id 11555652)1, 2, 9 Wallace A.D. and Cidlowski J.A. (J. Biol. Chem. 2001)
    10. Genetic variations of the NR3C1 gene in children with sporadic nephrotic syndrome. (PubMed id 16890204)1, 4, 9 Ye J....Meng Q. (Biochem. Biophys. Res. Commun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2908 HGNC: 7978 AceView: NR3C1 Ensembl:ENSG00000113580 euGenes: HUgn2908
    ECgene: NR3C1 Kegg: 2908 H-InvDB: NR3C1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NR3C1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=NR3C1[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nr3c1/
    Wikipedia http://en.wikipedia.org/wiki/Glucocorticoid_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NR3C1 gene:
    Search GeneIP for patents involving NR3C1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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