Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NR3C1 Gene

protein-coding GIFtS: 71
GCID: GC05M142639

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid...

(Previous names: nuclear receptor subfamily 3, group C, member 1 )
(Previous symbol: GRL)

Explore 205 diseases affiliated with
NR3C1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor)¹ ²		GCCR²
GRL¹ ² ³ ⁵		Glucocorticoid Nuclear Receptor Variant 1²
GR¹ ² ³		Glucocorticoid Receptor²
GCR² ⁵		Nuclear Receptor Subfamily 3 Group C Member 1³
Nuclear Receptor Subfamily 3, Group C, Member 1¹

External Ids:	HGNC: 7978¹	Entrez Gene: 2908²	Ensembl: ENSG00000113580⁷	OMIM: 138040⁵	UniProtKB: P04150³

Export aliases for NR3C1 gene to outside databases

Previous GC identifers: GC05M142559 GC05M143241 GC05M142687 GC05M137804

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR3C1:

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to

glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription,

and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand

binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and

differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance.

Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms.

Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been

described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct

transcriptional activities (PMID:15866175). (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: GCR_HUMAN, P04150

Function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to

glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other

transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues.

Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an

essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role

in transactivation

summary for NR3C1:

Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes

mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB

proteins, which are shed upon activation. The major signaling pathway used by GRs is via direct DNA binding

and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly

with transcription factors such as NF-kappaB, AP-1 or STAT. GRs are ubiquitously expressed and mediate a

vast array of physiological functions. Glucocorticoids regulate carbohydrate, protein and fat metabolism,

modulate immune responses through supression of chemokine and cytokine production and have critical roles in

constitutive activity of the CNS, digestive, hematopoietic, renal and reproductive systems. The human gene

encoding the glucocorticoid receptor has been localized to 5q31-q32.

Gene Wiki entry for NR3C1 (Glucocorticoid receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NR3C1 gene promoter:
AP-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR3C1 promoter sequence

Search SABiosciences Chromatin IP Primers for NR3C1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR3C1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31-q32

NR3C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR3C1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M142639: view genomic region (about GC identifiers)

Start:	142,657,496 bp from pter	End:	142,815,077 bp from pter
Size:	157,582 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GCR_HUMAN, P04150 (See protein sequence)

Recommended Name: Glucocorticoid receptor

Size: 777 amino acids; 85659 Da

Subunit: Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin

homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes

its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates

(By similarity). Binds to DNA as a homodimer, and as a heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A

and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with NCOA1, NCOA3,

SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with several coactivator complexes, including the

SMARCA4 complex, CREBBP/EP300, TADA2L and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits

transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1

Subcellular location: Cytoplasm. Mitochondrion. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after

ligand-binding

Subcellular location: Isoform Beta: Nucleus. Note=Localized largely in the nucleus

Miscellaneous: High constitutive expression of isoform beta by neutrophils may provide a mechanism by which these cells

escape glucocorticoid-induced cell death. Up-regulation by proinflammatory cytokines such as IL8 further enhances

their survival in the presence of glucocorticoids during inflammation

Miscellaneous: Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides

derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of

expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a

well-characterized transcriptional regulator

6/11 PDB 3D structures from and Proteopedia for NR3C1 (see all 11):

1M2Z (3D)

1NHZ (3D)

1P93 (3D)

3BQD (3D)

3CLD (3D)

3E7C (3D)

Secondary accessions: A0ZXF9 B0LPG8 D3DQF4 P04151 Q53EP5 Q6N0A4

Alternative splicing, Alternative initiation: 10 isoforms: P04150-1 P04150-2 P04150-3 P04150-6 P04150-5 P04150-7 P04150-4 P04150-8

P04150-9 P04150-10 (Produced by alternative initiation at Met-27 of isoform Beta)

Explore the universe of human proteins at neXtProt for NR3C1: NX_P04150

Post-translational modifications:

Increased proteasome-mediated degradation in response to glucocorticoids¹

Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The

Ser-203-phosphorylated form is mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Transcriptional

activity correlates with the amount of phosphorylation at Ser-211¹

Sumoylated; this reduces transcription transactivation¹

Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04150

NR3C1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (15 alternative transcripts):

NP_000167.1 NP_001018084.1 NP_001018085.1 NP_001018086.1 NP_001018087.1 NP_001018661.1 NP_001019265.1 NP_001191187.1

NP_001191188.1 NP_001191189.1 NP_001191190.1 NP_001191191.1 NP_001191192.1 NP_001191193.1 NP_001191194.1

ENSEMBL proteins:

ENSP00000377977 ENSP00000387672 ENSP00000422518 ENSP00000377979 ENSP00000231509

ENSP00000427672 ENSP00000424747 ENSP00000425313 ENSP00000420856 ENSP00000426478

ENSP00000425374 ENSP00000343205 ENSP00000405282 ENSP00000404218

Reactome Protein details: P04150
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): NR3C1 OriGene Custom Protein Services for NR3C1
	GenScript Custom Purified and Recombinant Proteins Services for NR3C1
	Novus Biologicals NR3C1 Proteins Novus Biologicals NR3C1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NR3C1

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

NR3C1 for ontologies About GeneDecksing

NR3C1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NR3C1
	R&D Systems Antibodies for NR3C1 (GR/NR3C1)
	Cell Signaling Technology (CST) Antibodies for NR3C1 (GR)
	OriGene Antibodies (see all 2): NR3C1 OriGene Custom Antibody Services for NR3C1
	GenScript Superior Antibodies for NR3C1
	Novus Biologicals NR3C1 Antibodies
	Abcam antibodies for NR3C1
	Uscn Antibodies for NR3C1
	ThermoFisher Antibody for NR3C1

Assay Products for NR3C1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NR3C1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NR3C1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NR3C1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013088 Znf_NHR/GATA

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

IPR001628 Znf_hrmn_rcpt

IPR001723 Str_hrmn_rcpt

Graphical View of Domain Structure for InterPro Entry P04150

ProtoNet protein and cluster: P04150

2 Blocks protein families:

IPB001409 Glucocorticoid receptor signature

IPB001723 Steroid hormone receptor signature

UniProtKB/Swiss-Prot: GCR_HUMAN, P04150

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding

domain

Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GCR_HUMAN, P04150

Function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to

glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other

transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues.

Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an

essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role

in transactivation

Genatlas biochemistry entry for NR3C1:

nuclear recptor subafamily 3,group C,member 1,steroid/thyroid hormone receptor superfamily,interacting with

tissue-specific transcriptional activators required for receptor actin (see HNFS)

		10/1359 SABiosciences Target genes for NR3C1 (see all 1359):
		A2M ABCA10 ABCA8 ABCC3 ABCC4 ABCC6 ABCC8 ABCC9 ABCD2 ABCG4

miRNA Products:		miRTarBase miRNAs that target NR3C1: hsa-mir-124 (MIRT004546), hsa-mir-18a (MIRT004545)

		OriGene 3'-UTR Clone (see all 7): NR3C1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NR3C1
		8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate NR3C1 (see all 161):
		hsa-miR-411* hsa-miR-199a-3p hsa-miR-1273d hsa-miR-376a* hsa-miR-642b hsa-miR-200b hsa-miR-200c* hsa-miR-147

		SwitchGear 3'UTR luciferase reporter plasmid: NR3C1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR3C1 (see all 7) OriGene shRNA RFP: NR3C1 OriGene siRNA: NR3C1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR3C1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NR3C1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR3C1 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR3C1 (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 15): NR3C1 (NM_001024094)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR3C1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR3C1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NR3C1
		Search LifeMap BioReagents cell lines for NR3C1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR3C1

Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003682	chromatin binding	--	--
GO:0003690	double-stranded DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003707	steroid hormone receptor activity	--	--

NR3C1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NR3C1:

Decreased viability

Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for NR3C1: Nr3c1^tm1Ljm Nr3c1^tm1Gsc Nr3c1^tm2.1Gsc
15/20 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Nr3c1) (see all 20):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
integument	liver/biliary system	mortality/aging	nervous system	no phenotypic analysis

NR3C1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

Development_Prolactin receptor signaling

Development_Prolactin receptor signaling

1.00

Development Prolactin receptor signaling

1.00

Immune response_MIF-JAB1 signaling

Immune response_MIF-JAB1 signaling

1.00

Immune response MIF-JAB1 signaling

0.97

Nuclear Receptor transcription pathway

Nuclear Receptor transcription pathway

1.00

Nuclear Receptors

0.68

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for NR3C1 (see all 8)

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Development Glucocorticoid receptor signaling
	Selected targets of GCR-alpha
	Proteolysis Putative SUMO-1 pathway
	Immune response IL-6 signaling pathway

1 R&D Systems Pathway for NR3C1

TGF-beta Signaling Pathways

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NR3C1

	Glucocorticoid Receptor Signaling
	NTHi-Induced Signaling
	Prolactin Signaling
	MIF Mediated Glucocorticoid Regulation

5/7 GeneGo (Thomson Reuters) Pathways for NR3C1 (see all 7)

	Immune response IL-6 signaling pathway
	Immune response MIF-mediated glucocorticoid regulation
	Development Prolactin receptor signaling
	Proteolysis Putative SUMO-1 pathway
	Transcription Role of VDR in regulation of genes involved in osteoporosis

5/10 BioSystems Pathways for NR3C1 (see all 10)

	SIDS Susceptibility Pathways
	Serotonin Receptor 4/6/7 and NR3C Signaling
	Adipogenesis
	Nuclear Receptors
	IL-2 Signaling Pathway

3 Reactome Pathways for NR3C1

	Generic Transcription Pathway
	Nuclear Receptor transcription pathway
	Gene Expression

2 PharmGKB Pathways for NR3C1

	Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
	Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

1 Kegg Pathway (Kegg details for NR3C1):

Neuroactive ligand-receptor interaction

NR3C1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NR3C1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/237 Interacting proteins for NR3C1 (P04150^{1, 2, 3} ENSP00000231509⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 237)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LCK	P06239²^,³, ENSP00000337825⁴	MINT-3373935 MINT-3374072 MINT-3373920 I2D: score=2 STRING: ENSP00000337825
SFN	P31947²^,³, ENSP00000340989⁴	MINT-14116 MINT-14115 I2D: score=3 STRING: ENSP00000340989
CD4	P01730²^,³, ENSP00000011653⁴	MINT-3373972 MINT-3373954 I2D: score=1 STRING: ENSP00000011653
CD3D	P04234²^,³, ENSP00000300692⁴	MINT-3374054 I2D: score=1 STRING: ENSP00000300692
HMOX2	P30519²^,³	MINT-8258368 I2D: score=2

About this table

Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006111	regulation of gluconeogenesis	IEA	--
GO:0006338	chromatin remodeling	--	--
GO:0006351	transcription, DNA-dependent	TAS	10887960
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	8621628

NR3C1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NR3C1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for NR3C1

Compounds for NR3C1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Mifepristone	Progesterone and glucocorticoid antagonist	[84371-65-3]
GSK 9027	Glucocorticoid receptor agonist	[1229096-88-1]
Dexamethasone	Anti-inflammatory glucocorticoid	[50-02-2]
Budesonide	Synthetic glucocorticoid; anti-inflammatory and chemopreventive	[51333-22-3]
Fluticasone propionate	Selective high affinity glucocorticoid agonist	[80474-14-2]

4 HMDB Compounds for NR3C1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Aldosterone	(+)-Aldosterone (see all 22)	52-39-1	17602195
Cortexolone	11-Deoxy-17-hydroxycorticosterone (see all 21)	152-58-9	3741883
Deoxycorticosterone	11-Dehydroxycorticosterone (see all 21)	64-85-7	3741883
Cortisol	11-Hydrocortisone (see all 173)	50-23-7	--

10/39 DrugBank Compounds for NR3C1 (see all 39) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Amcinonide	--	51022-69-6	target	agonist	16895953 17139284 17016423 16980198 16891588 17086345 17038445
Cortisone acetate	--	50-04-4	target	agonist	7062741 16895953 7054210 16980198 16891588 17086345 17038445
Flunisolide	--	3385-03-3	target	agonist	2386110 15285788 8466638 11752352 11368283 9563368 9523318
Budesonide	--	51333-22-3	target	antagonist	12920235 12601049 11258648 11730731 11752352 11040338
Desoximetasone	--	382-67-2	target	agonist	16895953 10754457 16980198 16891588 17086345 17038445
Dexamethasone	Desametasone (see all 9)	50-02-2	target	agonist	16956592 16835395 16971495 11752352 16891588 16963802
Fluorometholone	Fluormetholon (see all 4)	426-13-1	target	agonist	15684812 16895953 16980198 16891588 17086345 17038445
Fluticasone Propionate	--	80474-14-2	target	agonist	7878687 11730731 10200007 10518812 11752352 8646863
Megestrol	Megestrol Acetate (see all 5)	3562-63-8	target	agonist	9195366 18411198 9744490 6222739 2982481 15595341
Paramethasone	--	53-33-8	target	agonist	16895953 16980198 16891588 17086345 16255837 17038445

10/120 Novoseek chemical compound relationships for NR3C1 gene (see all 120) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dexamethasone	91.8	1114	8574285 (4), 12781044 (4), 19167480 (4), 18657064 (4) (see all 99)
mifepristone	91.4	396	19635558 (8), 17509631 (5), 12695529 (4), 14671179 (3) (see all 99)
steroid	86	485	15155759 (4), 16890204 (4), 2168876 (3), 9731032 (3) (see all 99)
11beta-hydroxysteroid	85.6	72	11836450 (3), 15866114 (2), 19048413 (2), 10588816 (1) (see all 52)
cortisone	78.3	32	15062542 (2), 16178882 (2), 15780662 (1), 8200959 (1) (see all 21)
cortivazol	76.6	24	11741935 (4), 2205477 (2), 15677712 (2), 2039752 (2) (see all 7)
androstane	75.5	44	16399345 (2), 19541828 (2), 16188404 (2), 15933212 (2) (see all 24)
progesterone	74.3	351	1920329 (4), 20156884 (4), 2249895 (3), 18060946 (3) (see all 99)
corticosterone	72.2	114	2257242 (3), 17446698 (3), 12538030 (3), 10624831 (2) (see all 59)
fluticasone propionate	69	48	15860753 (3), 10200007 (3), 9087160 (2), 12503693 (2) (see all 29)

Search CenterWatch for drugs/clinical trials and news about NR3C1 / GCR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NR3C1 gene (15 alternative transcripts):

NM_000176.2 NM_001018074.1 NM_001018075.1 NM_001018076.1 NM_001018077.1 NM_001020825.1 NM_001024094.1 NM_001204258.1

NM_001204259.1 NM_001204260.1 NM_001204261.1 NM_001204262.1 NM_001204263.1 NM_001204264.1 NM_001204265.1

Unigene Cluster for NR3C1:

Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Hs.122926 [show with all ESTs]

Unigene Representative Sequence: NM_001018077

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394464(uc003lmy.3 uc003lmz.3 uc003lna.3 uc003lnb.3 uc011dbk.2)

ENST00000415690 ENST00000504572 ENST00000394466(uc003lni.2) ENST00000231509(uc021yfb.1)

ENST00000503201(uc021yfa.1 uc003lng.2) ENST00000504336 ENST00000510170

ENST00000508760 ENST00000502892 ENST00000514699 ENST00000502500 ENST00000503701

ENST00000505058 ENST00000343796(uc003lnc.3 uc003lnf.3 uc003lnd.3 uc003lne.3)

ENST00000424646 ENST00000416954

miRNA Products:		OriGene 3'-UTR Clone (see all 7): NR3C1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NR3C1
		8/161 QIAGEN miScript miRNA Assays for microRNAs that regulate NR3C1 (see all 161):
		hsa-miR-411* hsa-miR-199a-3p hsa-miR-1273d hsa-miR-376a* hsa-miR-642b hsa-miR-200b hsa-miR-200c* hsa-miR-147

		SwitchGear 3'UTR luciferase reporter plasmid: NR3C1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR3C1 (see all 7) OriGene shRNA RFP: NR3C1 OriGene siRNA: NR3C1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR3C1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR3C1 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR3C1 (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 15): NR3C1 (NM_001024094)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR3C1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR3C1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR3C1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NR3C1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR3C1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR3C1

Additional cDNA sequence:

AB307716.1 AJ877166.1 AJ877167.1 AJ877168.1 AJ877169.1 AJ877170.1 AJ877171.1 AJ877172.1

AJ888004.1 AK223594.1 AK302050.1 AK314789.1 AM183262.1 BC015610.2 BX640610.1 BX648553.1

HQ692822.1 JN797823.1 JN797824.1 U01351.1 U25029.1 X03225.1 X03348.1

23 DOTS entries:

DT.100786784 DT.99998911 DT.85105550 DT.95296381 DT.95269160 DT.100786795 DT.100786792 DT.207488

DT.92441907 DT.102832223 DT.120796451 DT.120796581 DT.40126589 DT.120796608 DT.100786783 DT.100786785

DT.120796481 DT.218847 DT.100037621 DT.100737448 DT.100786786 DT.100786788 DT.120796605

24/383 AceView cDNA sequences (see all 383):

AU139241 AA234527 BQ433598 BE739816 BU619054 CA777596 AI934556 AA252235

BU147202 CA416785 AA437348 CB132485 CA392568 BQ005253 AW299567 AA382009

BM310859 CB112400 BQ030399 CA310206 U01351 BE875671 BF433954 BM468899

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NR3C1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NR3C1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Muscle Progenitor Cells

Skeletal Muscle

Mandibular Arch Muscles

Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NR3C1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR3C1

SOURCE GeneReport for Unigene cluster: Hs.122926

UniProtKB/Swiss-Prot: GCR_HUMAN, P04150

Tissue specificity: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta,

apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart

SABiosciences Expression via Pathway-Focused PCR Arrays including NR3C1 (see all 10):

Nuclear Receptors & Coregulators in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

T-cell & B-cell Activation in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR3C1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NR3C1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR3C1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR3C1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR3C1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NR3C1 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nr3c1^{1 , 5}	nuclear receptor subfamily 3, group C, member 1^{1, 5}	89.58(n)¹ 90.7(a)¹		18 (21.09 cM)⁵ 14815¹ NM_008173.3¹ NP_032199.3¹ 39410545⁵
chicken (Gallus gallus)	Aves	NR3C1¹	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid more	74.25(n) 75.81(a)		416343 NM_001037826.1 NP_001032915.1
lizard (Anolis carolinensis)	Reptilia	NR3C1⁶	--	75(a)	1 ↔ 1	2(126275215-126336129)
African clawed frog (Xenopus laevis)	Amphibia	xGR²	glucocorticoid receptor protein	76.06(n)		X72211.1
zebrafish (Danio rerio)	Actinopterygii	CB362131.1²	--	72.79(n)		CB362131.1
worm (Caenorhabditis elegans)	Secernentea	nhr-25⁶	Nuclear hormone receptor family member nhr-25	13(a)	1 → many	X(13008424-13013892)

ENSEMBL Gene Tree for NR3C1 (if available)
TreeFam Gene Tree for NR3C1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NR3C1 gene

ESRRA² RXRG² PGR² ESR2² ESRRB² HNF4G² NR2F6² NR2E1²

ESRRG² NR3C2² RXRA² NR2F1² NR2F2² AR² ESR1² NR2C1²

HNF4A² NR2C2² RXRB²

16 SIMAP similar genes for NR3C1 using alignment to 14 protein entries: GCR_HUMAN (see all proteins):

NR5A1 NR3C4 ESR1 VDR NR1I3 HNF4G

RORA PGR AR HNF4alpha NR3C2 ESRRB

ESR2 PPARA ESRRA ERRgamma

NR3C1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for NR3C1
PGOHUM00000249184

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: GCR_HUMAN, P04150

Polymorphism: Carriers of the 22-Glu-Lys-23 allele are relatively more resistant to the effects of GCs with respect to

the sensitivity of the adrenal feedback mechanism than non-carriers, resulting in a better metabolic health profile.

Carriers have a better survival than non-carriers, as well as lower serum CRP levels. The 22-Glu-Lys-23 polymorphism

is associated with a sex-specific, beneficial body composition at young-adult age, as well as greater muscle strength

in males

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56149945^1,2	C,F,	non-pathogenic	162638002(-)	`CGAAAA/G/TTTGGA`	45	N S I	mis¹		25		NS MN WA EA CSA NA EU	11922
rs104893913^1,2	C	pathogenic	162727619(-)	`ATGCCA/GCTATC`	30	H R	mis¹		0	--	--	--	--
rs104893909^1,2	C	pathogenic	162737194(-)	`GAGGAA/TCATGA`	30	N I	mis¹		0	--	--	--	--
rs104893908^1,2	C	pathogenic	162742189(-)	`GTACGA/TCCAAT`	30	D V	mis¹		0	--	--	--	--
rs104893914^1,2	C	pathogenic	162754972(-)	`AGGACA/GGTCTG`	28	S G	mis¹		0	--	--	--	--
rs104893910^1,2	C	pathogenic	162755704(-)	`AGTATG/TGAATT`	27	M I	mis¹ int¹		0	--	--	--	--
rs17287758^1,2	C,F,H,	--	137804258(+)	`GAATGG/AATTGT`	14	--	ds500¹		25		NA NS EA CSA WA	4448
rs61754805^1,2	F	--	137804259(-)	`TACAAT/CCCATT`	14	--	ds500¹		3		NS	2006
rs61754804^1,2	F	--	137804390(-)	`CTAGTC/GAAAAT`	14	--	ds500¹		3		NS	1996
rs17209237^1,2	C,F,H,	--	137804449(+)	`TTTGAA/GGCAGC`	14	--	ds500¹		23		NA NS EA	4350

HapMap Linkage Disequilibrium report for NR3C1 (142657496 - 142815077 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NR3C1
2 CNVs: 7475 6451
2 Indels: 46781 12763
Human Gene Mutation Database (HGMD): NR3C1

Locus Specific Mutation Databases (LSDB): NR3C1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR3C1

DNA2.0 Custom Variant and Variant Library Synthesis for NR3C1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NR3C1 for disorders About GeneDecksing

OMIM gene information: 138040 OMIM disorders: --

UniProtKB/Swiss-Prot: GCR_HUMAN, P04150

Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:138040]; also known as cortisol

resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations.

Inheritance is autosomal dominant

20/205 diseases for NR3C1 (see all 205): About MalaCards

glucocorticoid-remediable aldosteronism corticosteroid-binding globulin deficiency glucocorticoid resistance dosage-sensitive sex reversal

open-angle glaucoma post-traumatic stress disorder pituitary-dependent cushing's disease 21-hydroxylase deficiency

estrogen-receptor negative breast cancer pre-b-cell acute lymphoblastic leukemia spinal cord injury primary pigmented nodular adrenocortical disease

sex reversal treacher collins syndrome primary open angle glaucoma cortisol resistance

patent ductus arteriosus enhanced s-cone syndrome glucose intolerance primary cortisol resistance

1 disease from the University of Copenhagen DISEASES database for NR3C1:

Proteinuria

10/91 Novoseek disease relationships for NR3C1 gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cushing syndrome	69.7	17	10802524 (2), 1794941 (1), 16456492 (1), 16855182 (1) (see all 13)
mammary tumor	63.9	36	1871124 (2), 10748103 (2), 2159467 (1), 8407999 (1) (see all 28)
hypercortisolism	61.5	4	17587649 (1), 10995524 (1), 16118334 (1), 18406688 (1)
hypercortisolemia	61.2	8	16546487 (1), 12399952 (1), 17037809 (1), 11131467 (1) (see all 5)
asthma	55.9	137	18799869 (5), 9560836 (4), 18952539 (3), 9329880 (3) (see all 66)
major depression	55.3	70	11274650 (5), 16019586 (4), 12727135 (3), 12242054 (2) (see all 36)
acth syndrome ectopic	49.5	4	8396510 (1), 7958079 (1), 20015838 (1), 8254033 (1)
shock	46.3	151	11463862 (8), 8745575 (5), 14673132 (4), 7917000 (3) (see all 69)
nasal polyps	44.6	18	18671773 (3), 19848249 (2), 18396779 (2), 11800371 (2) (see all 9)
inflammation	43.3	44	10435109 (2), 18821468 (2), 9482836 (1), 15541765 (1) (see all 32)

Genetic Association Database (GAD): NR3C1
Human Genome Epidemiology (HuGE) Navigator: NR3C1 (169 documents)

Export disorders for NR3C1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NR3C1 gene, integrated from 9 sources (see all 2367):
(articles sorted by number of sources associating them with NR3C1)

Utopia: connect your pdf to the dynamic
world of online information

The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. (PubMed id 15292341)^{1, 2, 4} van Rossum E.F.C.... Lamberts S.W.J. (2004)
Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. (PubMed id 15276593)^{1, 2, 4} van Rossum E.F.C.... Lamberts S.W.J. (2004)
A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. (PubMed id 12351458)^{1, 2, 4} van Rossum E.F.C.... Lamberts S.W.J. (2002)
Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance. (PubMed id 9150737)^{1, 2, 4} Koper J.W....Lamberts S.W.J. (1997)
Primary structure and expression of a functional human glucocorticoid receptor cDNA. (PubMed id 2867473)^{1, 2, 3} Hollenberg S.M.... Evans R.M. (1985)
Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids. (PubMed id 11555652)^{1, 2, 9} Wallace A.D. and Cidlowski J.A. (2001)
Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells. (PubMed id 12920235)^{1, 7, 9} Kunz S....Miesfeld R.L. (2003)
Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor. (PubMed id 10639135)^{1, 2, 9} Diamond M.I.... Yamamoto K.R. (2000)
Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes. (PubMed id 8316249)^{1, 2, 9} Ashraf J. and Thompson E.B. (1993)
Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the Heart and Soul study. (PubMed id 20371666)^{1, 7, 9} Otte C....Whooley M.A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2908	HGNC: 7978	AceView: NR3C1	Ensembl:ENSG00000113580	euGenes: HUgn2908
ECgene: NR3C1	Kegg: 2908	H-InvDB: NR3C1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NR3C1	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NR3C1
NIEHS-SNPs	http://egp.gs.washington.edu/data/nr3c1/
Wikipedia	http://en.wikipedia.org/wiki/Glucocorticoid_receptor

Intellectual Property for NR3C1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NR3C1 gene:
Search GeneIP for patents involving NR3C1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of NR3C1
	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for NR3C1 (GR/NR3C1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for NR3C1		OriGene shRNA RFP for NR3C1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR3C1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR3C1
	OriGene Protein Over-expression Lysate for NR3C1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for NR3C1		OriGene 3'-UTR Clone for NR3C1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR3C1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR3C1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NR3C1		OriGene Custom Protein Services for NR3C1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NR3C1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR3C1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR3C1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR3C1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR3C1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR3C1

	GenScript Custom Purified and Recombinant Proteins Services for NR3C1		GenScript cDNA clones with any tag delivered in your preferred vector for NR3C1
	GenScript Custom Assay Services for NR3C1		GenScript Superior Antibodies for NR3C1
	GenScript Custom overexpressing Cell Line Services for NR3C1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for NR3C1 (GR)

	Regulatory tfbs in NR3C1 promoter
	Search Chromatin IP Primers for NR3C1
	RT² qPCR Primer Assay in human, mouse, rat NR3C1
	GNC Network for NR3C1
	SABiosciences PCR Arrays including human, mouse, rat NR3C1

Tocris compounds for NR3C1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs for NR3C1
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NR3C1 antibodies
	NR3C1 proteins
	NR3C1 lysates

	Antibodies for NR3C1
	See all of Abcam's Antibodies, Kits and Proteins for NR3C1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

NR3C1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NR3C1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR3C1

	SwitchGear 3'UTR luciferase reporter plasmids for NR3C1
	SwitchGear Promoter luciferase reporter plasmids for NR3C1

ThermoFisher Antibody for NR3C1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR3C1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NR3C1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

NR3C1 Gene

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid...

Aliases
for NR3C1 gene

Summaries
for NR3C1 gene

Genomic Views
for NR3C1 gene

Proteins
for NR3C1 gene

Protein Domains /
Families
for NR3C1 gene

Function
for NR3C1 gene

Pathways & Interactions
for NR3C1 gene

Drugs & Compounds
for NR3C1 gene

Transcripts
for NR3C1 gene

Expression
for NR3C1 gene

Orthologs
for NR3C1 gene

Paralogs
for NR3C1 gene

Genomic Variants
for NR3C1 gene

Disorders / Diseases
for NR3C1 gene

Publications
for NR3C1 gene

External Searches for NR3C1 gene

Genome Databases showing NR3C1 gene

Other Databases showing NR3C1 gene

Specialized Databases showing NR3C1 gene

Intellectual Property
for NR3C1 gene

Products
for NR3C1 gene

View Random Gene

Lymphoblastic Leukemia Acute Childhood
Dementia
Kaposi Sarcoma
hypercortisolemia
essential hypertension
Colitis Ulcerative
Hyperlipidemia
AIRWAYS DISEASE
Glucose Intolerance
TREACHER COLLINS SYNDROME
insulin sensitivity
Liver diseases
Respiratory Distress Syndrome
Breast Cancer
NSCLC
Stress Psychological
Schizophrenia
Asthma
Nephrotic Syndrome
AIDS
Adenocarcinoma
Allergic rhinitis
GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM
Cancer
Mood Disorders
mammary tumor
Depressive state
Shock
Nasal Polyps
Malnutrition
Inflammation
PSEUDOHERMAPHRODITISM FEMALE
Proteinuria
Neuroepithelial Tumors
ACTH Syndrome Ectopic
Liddles syndrome
Stress Disorders Posttraumatic
Adrenal Hyperplasia Congenital
Cervical Cancer
Pulmonary Disease Chronic Obstructive
Bipolar Disorder
Pituitary-dependent Cushings disease
psychiatric disorder
MYELOMA
Rheumatoid Arthritis
prostate cancer
Depressive disorder
Necrosis
Lymphoblastic Leukemia Acute
metabolic disorder
virus infection
ENDOCRINE DISORDER
Preeclampsia
Hyperandrogenism
Cushing Syndrome
Coronary Heart Disease
major depression
Gastric Cancer
Autoimmune Diseases
Neurological Disorders
Hyperplasia
PITUITARY ADENOMA
Central giant cell granuloma
Carcinoma
Osteoarthritis
VIRILIZATION
Leukemia
Diabetes Mellitus
Osteosarcoma
Osteoporosis
Ocular Hypertension
HEPATOCELLULAR CARCINOMA
Hematologic Malignancies
hypercortisolism
small cell lung cancer
Inflammatory Bowel Diseases
Chronic Fatigue Syndrome
Insulin Resistance
HIV Infections
T-ALL
OBESITY
Rhinitis Allergic Perennial
solid tumor
SKIN LESION
Granuloma
NIDDM
Hypokalemia
LEUKAEMIA LYMPHOCYTIC
Nelson Syndrome
Cardiac Arrest
PSYCHOTIC DEPRESSION

Advanced Search

Export list of displayed genes

NR3C1 Gene

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid...

Aliasesfor NR3C1 gene

Summariesfor NR3C1 gene

Genomic Viewsfor NR3C1 gene

Proteinsfor NR3C1 gene

Protein Domains /Familiesfor NR3C1 gene

Functionfor NR3C1 gene

Pathways & Interactionsfor NR3C1 gene

Drugs & Compoundsfor NR3C1 gene

Transcriptsfor NR3C1 gene

Expression for NR3C1 gene

Orthologsfor NR3C1 gene

Paralogsfor NR3C1 gene

Genomic Variantsfor NR3C1 gene

Disorders / Diseasesfor NR3C1 gene

Publicationsfor NR3C1 gene

External Searches for NR3C1 gene

Genome Databases showing NR3C1 gene

Other Databases showing NR3C1 gene

Specialized Databases showing NR3C1 gene

Intellectual Propertyfor NR3C1 gene

Productsfor NR3C1 gene

View Random Gene

Aliases
for NR3C1 gene

Summaries
for NR3C1 gene

Genomic Views
for NR3C1 gene

Proteins
for NR3C1 gene

Protein Domains /
Families
for NR3C1 gene

Function
for NR3C1 gene

Pathways & Interactions
for NR3C1 gene

Drugs & Compounds
for NR3C1 gene

Transcripts
for NR3C1 gene

Expression
for NR3C1 gene

Orthologs
for NR3C1 gene

Paralogs
for NR3C1 gene

Genomic Variants
for NR3C1 gene

Disorders / Diseases
for NR3C1 gene

Publications
for NR3C1 gene

Intellectual Property
for NR3C1 gene

Products
for NR3C1 gene