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Aliases for NR3C1 Gene

Aliases for NR3C1 Gene

  • Nuclear Receptor Subfamily 3 Group C Member 1 2 3 4 5
  • Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) 2 3
  • GRL 3 4
  • GR 3 4
  • Nuclear Receptor Subfamily 3, Group C, Member 1 2
  • Glucocorticoid Nuclear Receptor Variant 1 3
  • Glucocorticoid Receptor 2
  • GCRST 3
  • GCCR 3
  • GCR 3

External Ids for NR3C1 Gene

Previous HGNC Symbols for NR3C1 Gene

  • GRL

Previous GeneCards Identifiers for NR3C1 Gene

  • GC05M142559
  • GC05M142687
  • GC05M142639
  • GC05M137804

Summaries for NR3C1 Gene

Entrez Gene Summary for NR3C1 Gene

  • This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

GeneCards Summary for NR3C1 Gene

NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. Diseases associated with NR3C1 include Glucocorticoid Resistance and Cushing's Syndrome. Among its related pathways are Gene Expression and Signaling by PTK6. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is AR.

UniProtKB/Swiss-Prot for NR3C1 Gene

  • Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Tocris Summary for NR3C1 Gene

  • Glucocorticoid receptors (GRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, progesterone and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation.

Gene Wiki entry for NR3C1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR3C1 Gene

Genomics for NR3C1 Gene

Regulatory Elements for NR3C1 Gene

Enhancers for NR3C1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NR3C1 on UCSC Golden Path with GeneCards custom track

Promoters for NR3C1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NR3C1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NR3C1 gene promoter:

Genomic Location for NR3C1 Gene

Chromosome:
5
Start:
143,277,931 bp from pter
End:
143,435,512 bp from pter
Size:
157,582 bases
Orientation:
Minus strand

Genomic View for NR3C1 Gene

Genes around NR3C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR3C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR3C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR3C1 Gene

Proteins for NR3C1 Gene

  • Protein details for NR3C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04150-GCR_HUMAN
    Recommended name:
    Glucocorticoid receptor
    Protein Accession:
    P04150
    Secondary Accessions:
    • A0ZXF9
    • B0LPG8
    • D3DQF4
    • P04151
    • Q53EP5
    • Q6N0A4

    Protein attributes for NR3C1 Gene

    Size:
    777 amino acids
    Molecular mass:
    85659 Da
    Quaternary structure:
    • Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1. Interacts with CLOCK, CRY1 and CRY2 in a ligand-dependent fashion. Interacts with CIART. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with GRIP1 (PubMed:15769988). Interacts with NR4A3 (via nuclear receptor DNA-binding domain), represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE) (PubMed:15591535).
    Miscellaneous:
    • Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator.
    • High constitutive expression of isoform Beta by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death. Up-regulation by proinflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation.

    Three dimensional structures from OCA and Proteopedia for NR3C1 Gene

    Alternative splice isoforms for NR3C1 Gene

neXtProt entry for NR3C1 Gene

Proteomics data for NR3C1 Gene at MOPED

Post-translational modifications for NR3C1 Gene

  • Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.
  • Increased proteasome-mediated degradation in response to glucocorticoids.
  • Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203-phosphorylated form is mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211. May be dephosphorylated by PPP5C, attenuates NR3C1 action.
  • Sumoylated; this reduces transcription transactivation.
  • Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
  • Ubiquitination at Lys 419
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NR3C1 Gene

Domains & Families for NR3C1 Gene

Gene Families for NR3C1 Gene

Graphical View of Domain Structure for InterPro Entry

P04150

UniProtKB/Swiss-Prot:

GCR_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
genes like me logo Genes that share domains with NR3C1: view

Function for NR3C1 Gene

Molecular function for NR3C1 Gene

GENATLAS Biochemistry:
nuclear recptor subafamily 3,group C,member 1,steroid/thyroid hormone receptor superfamily,interacting with tissue-specific transcriptional activators required for receptor actin (see HNFS)
UniProtKB/Swiss-Prot Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Gene Ontology (GO) - Molecular Function for NR3C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IDA 15769988
GO:0005515 protein binding IPI 9079630
GO:1990239 steroid hormone binding IDA 17635946
genes like me logo Genes that share ontologies with NR3C1: view
genes like me logo Genes that share phenotypes with NR3C1: view

Human Phenotype Ontology for NR3C1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NR3C1 Gene

MGI Knock Outs for NR3C1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NR3C1

CRISPR Products

miRNA for NR3C1 Gene

miRTarBase miRNAs that target NR3C1

Transcription Factor Targets for NR3C1 Gene

Selected GeneGlobe predicted Target genes for NR3C1
Targeted motifs for NR3C1 Gene
HOMER Transcription Factor Regulatory Elements motif NR3C1
  • Consensus sequence: NAGAACAGNCTGTTCT Submotif: IR3 Cell Type: A549 GEO ID: GSE32465

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for NR3C1 Gene

Localization for NR3C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR3C1 Gene

Cytoplasm. Mitochondrion. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding.
Isoform Beta: Nucleus. Note=Localized largely in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR3C1 Gene COMPARTMENTS Subcellular localization image for NR3C1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 2
peroxisome 2
plasma membrane 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for NR3C1 Gene

Pathways & Interactions for NR3C1 Gene

genes like me logo Genes that share pathways with NR3C1: view

SIGNOR curated interactions for NR3C1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR3C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 8621628
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007165 signal transduction TAS 7769088
GO:0010467 gene expression TAS --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with NR3C1: view

Drugs & Compounds for NR3C1 Gene

(129) Drugs for NR3C1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluticasone propionate Approved Pharma antagonist, Target, agonist Selective high affinity glucocorticoid receptor agonist 0
Hydrocortisone Approved Pharma Agonist, Target, agonist 594
Mifepristone Approved, Investigational Pharma Agonist, antagonist, Target Progesterone receptor antagonist, Progesterone and glucocorticoid receptor antagonist 144
Prednisolone Approved Pharma Agonist, binder, Target, agonist 1097
Triamcinolone Approved Pharma Agonist, binder, Target, agonist 455

(40) Additional Compounds for NR3C1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GSK 9027
1229096-88-1

(5) Tocris Compounds for NR3C1 Gene

Compound Action Cas Number
Corticosterone Endogenous glucocorticoid 50-22-6
Fluticasone propionate Selective high affinity glucocorticoid receptor agonist 80474-14-2
GSK 9027 Glucocorticoid receptor agonist 1229096-88-1
Methylprednisolone Glucocorticoid receptor agonist 83-43-2
Mometasone furoate Synthetic corticosteroid; anti-inflammatory agent 83919-23-7

(20) ApexBio Compounds for NR3C1 Gene

Compound Action Cas Number
Beclomethasone dipropionate Corticosteroid used for asthma and rhinitis 5534-09-8
Betamethasone Glucocorticoid receptor agonist 378-44-9
Betamethasone Dipropionate 5593-20-4
Betamethasone Valerate 2152-44-5
Budesonide Anti-inflammatory corticosteroid 51333-22-3
Cortisone acetate 1950-04-4
Deflazacort 14484-47-0
Desonide 638-94-8
Dexamethasone acetate 1177-87-3
Flumethasone 2135-17-3
Fluocinolone Acetonide 67-73-2
Fluocinonide 356-12-7
Fluorometholone Acetate 3801-06-7
Fluticasone propionate 80474-14-2
Hydrocortisone 50-23-7
Meprednisone 1247-42-3
Methylprednisolone Apoptosis inducer,GR agonist 83-43-2
Mifepristone Progesterone receptor antagonist 84371-65-3
Prednisolone 50-24-8
Triamcinolone 124-94-7
genes like me logo Genes that share compounds with NR3C1: view

Drug Products

Transcripts for NR3C1 Gene

Unigene Clusters for NR3C1 Gene

Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor):
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR3C1 Gene

No ASD Table

Relevant External Links for NR3C1 Gene

GeneLoc Exon Structure for
NR3C1
ECgene alternative splicing isoforms for
NR3C1

Expression for NR3C1 Gene

mRNA expression in normal human tissues for NR3C1 Gene

Protein differential expression in normal tissues from HIPED for NR3C1 Gene

This gene is overexpressed in Monocytes (17.3), CD8 Tcells (9.6), and Peripheral blood mononuclear cells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NR3C1 Gene



SOURCE GeneReport for Unigene cluster for NR3C1 Gene Hs.122926

mRNA Expression by UniProt/SwissProt for NR3C1 Gene

P04150-GCR_HUMAN
Tissue specificity: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
genes like me logo Genes that share expression patterns with NR3C1: view

Protein tissue co-expression partners for NR3C1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NR3C1 Gene

Orthologs for NR3C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NR3C1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NR3C1 35
  • 91.62 (n)
  • 94.33 (a)
GR-A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR3C1 35
  • 91.54 (n)
  • 93.43 (a)
NR3C1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr3c1 35
  • 89.58 (n)
  • 90.7 (a)
Nr3c1 16
Nr3c1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NR3C1 35
  • 99.7 (n)
  • 99.49 (a)
NR3C1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr3c1 35
  • 89.15 (n)
  • 91.09 (a)
oppossum
(Monodelphis domestica)
Mammalia NR3C1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR3C1 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR3C1 35
  • 74.04 (n)
  • 75.55 (a)
NR3C1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR3C1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr3c1 35
  • 69.96 (n)
  • 67.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia xGR 35
zebrafish
(Danio rerio)
Actinopterygii nr3c1 35
  • 58.15 (n)
  • 54.21 (a)
nr3c1 36
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11855 35
Species with no ortholog for NR3C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR3C1 Gene

ENSEMBL:
Gene Tree for NR3C1 (if available)
TreeFam:
Gene Tree for NR3C1 (if available)

Paralogs for NR3C1 Gene

Paralogs for NR3C1 Gene

Pseudogenes.org Pseudogenes for NR3C1 Gene

genes like me logo Genes that share paralogs with NR3C1: view

Variants for NR3C1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NR3C1 Gene

GCR_HUMAN-P04150
Carriers of the 22-Glu-Lys-23 allele are relatively more resistant to the effects of GCs with respect to the sensitivity of the adrenal feedback mechanism than non-carriers, resulting in a better metabolic health profile. Carriers have a better survival than non-carriers, as well as lower serum CRP levels. The 22-Glu-Lys-23 polymorphism is associated with a sex-specific, beneficial body composition at young-adult age, as well as greater muscle strength in males.

Sequence variations from dbSNP and Humsavar for NR3C1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_004675 -
VAR_004676 Glucocorticoid resistance, generalized (GCCR)
VAR_004677 Glucocorticoid resistance, generalized (GCCR)
VAR_004678 Two glucocorticoid resistant leukemia cell lines lacking the normal allele
VAR_013472 Glucocorticoid resistance, generalized (GCCR)

Structural Variations from Database of Genomic Variants (DGV) for NR3C1 Gene

Variant ID Type Subtype PubMed ID
esv33748 CNV Loss 17666407
nsv5041 CNV Loss 18451855
esv2730855 CNV Deletion 23290073
esv2730856 CNV Deletion 23290073
esv1954637 CNV Deletion 18987734
esv2730857 CNV Deletion 23290073
nsv328009 CNV Loss 16902084
nsv328818 CNV Loss 16902084
esv1001228 CNV Deletion 20482838
esv2730858 CNV Deletion 23290073
esv1765773 CNV Deletion 17803354
nsv327674 CNV Loss 16902084
nsv327858 CNV Loss 16902084
esv2666615 CNV Deletion 23128226
nsv882994 CNV Loss 21882294
esv1786342 CNV Insertion 17803354

Variation tolerance for NR3C1 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NR3C1 Gene

Human Gene Mutation Database (HGMD)
NR3C1

Disorders for NR3C1 Gene

MalaCards: The human disease database

(38) MalaCards diseases for NR3C1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glucocorticoid resistance
  • cortisol resistance from glucocorticoid receptor defect
cushing's syndrome
  • cushing syndrome
mental depression
  • depression
post-traumatic stress disorder
  • traumatic neurosis
lymphosarcoma
  • lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search NR3C1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GCR_HUMAN
  • Glucocorticoid resistance, generalized (GCCR) [MIM:615962]: An autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of Cushing syndrome typical signs. Clinical features include hypoglycemia, hypertension, metabolic alkalosis, chronic fatigue and profound anxiety. {ECO:0000269 PubMed:11589680, ECO:0000269 PubMed:11701741, ECO:0000269 PubMed:12050230, ECO:0000269 PubMed:15769988, ECO:0000269 PubMed:1704018, ECO:0000269 PubMed:17635946, ECO:0000269 PubMed:7683692}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NR3C1

Genetic Association Database (GAD)
NR3C1
Human Genome Epidemiology (HuGE) Navigator
NR3C1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR3C1
genes like me logo Genes that share disorders with NR3C1: view

No data available for Genatlas for NR3C1 Gene

Publications for NR3C1 Gene

  1. The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. (PMID: 15292341) van Rossum E.F.C. … Lamberts S.W.J. (J. Clin. Endocrinol. Metab. 2004) 3 4 48 67
  2. Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor. (PMID: 16971495) Wang D. … Yun C.C. (Am. J. Physiol., Cell Physiol. 2007) 3 23 25
  3. Identification of a novel glucocorticoid receptor mutation in budesonide-resistant human bronchial epithelial cells. (PMID: 12920235) Kunz S. … Miesfeld R.L. (Mol. Endocrinol. 2003) 3 23 25
  4. Estrogen receptor, progesterone receptor, and glucocorticoid receptor expression in normal breast tissue, breast in situ carcinoma, and invasive breast cancer. (PMID: 19875955) Buxant F. … NoAl J.C. (Appl. Immunohistochem. Mol. Morphol. 2010) 3 23
  5. Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations. (PMID: 19913032) Schoch G.A. … Ruf A. (J. Mol. Biol. 2010) 3 23

Products for NR3C1 Gene

Sources for NR3C1 Gene

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