Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NR2F6 Gene

protein-coding   GIFtS: 62
GCID: GC19M017342

Nuclear Receptor Subfamily 2, Group F, Member 6


(Previous symbol: ERBAL2)
  See NR2F6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nuclear Receptor Subfamily 2, Group F, Member 61 2     ERBA-Related Gene-22
ERBAL21 2 3 5     Nuclear Receptor Subfamily 2 Group F Member 62
EAR22 3 5     Nuclear Receptor V-ErbA-Related2
EAR-22 3     V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 22
V-ErbA-Related Protein 22 3     

External Ids:    HGNC: 79771   Entrez Gene: 20632   Ensembl: ENSG000001601137   OMIM: 1328805   UniProtKB: P105883   

Export aliases for NR2F6 gene to outside databases

Previous GC identifers: GC19M017836 GC19M017734 GC19M017187 GC19M017203 GC19M016910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NR2F6 Gene:
NR2F6 (nuclear receptor subfamily 2, group F, member 6) is a protein-coding gene. Diseases associated with NR2F6 include chronic purulent otitis media. GO annotations related to this gene include steroid hormone receptor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588
Function: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer
response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which
are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses
transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and
the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional
activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards
thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine
response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its
transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T
cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity.
Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus
(LC)

Gene Wiki entry for NR2F6 (V-erbA-related gene) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR2F6 gene promoter:
         TBP   CREB   deltaCREB   NF-kappaB1   NF-kappaB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNR2F6 promoter sequence
   Search Chromatin IP Primers for NR2F6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR2F6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

NR2F6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2F6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017342:  view genomic region     (about GC identifiers)

Start:
17,342,692 bp from pter      End:
17,356,749 bp from pter
Size:
14,058 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 2 group F member 6  
Size: 404 amino acids; 42979 Da
Subunit: Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1 (By similarity). Interacts
with THRB
Secondary accessions: B2RC68 Q5XGA0 Q6P586 Q9BUE8

Explore the universe of human proteins at neXtProt for NR2F6: NX_P10588

Explore proteomics data for NR2F6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NR2F6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005225.2  
    ENSEMBL proteins: 
     ENSP00000291442   ENSP00000471686  
    Reactome Protein details: P10588

    NR2F6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NR2F6
    OriGene Protein Over-expression Lysate for NR2F6
    OriGene MassSpec for NR2F6
    OriGene Custom Protein Services for NR2F6
    GenScript Custom Purified and Recombinant Proteins Services for NR2F6
    Novus Biologicals NR2F6 Protein
    Novus Biologicals NR2F6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NR2F6

     
    Search eBioscience for Proteins for NR2F6 

    NR2F6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NR2F6 (EAR2/NR2F6)
    OriGene Antibodies for NR2F6
    OriGene Custom Antibody Services for NR2F6
    Novus Biologicals NR2F6 Antibodies
    Abcam antibodies for NR2F6
    Cloud-Clone Corp. Antibodies for NR2F6
    ThermoFisher Antibodies for NR2F6
    LSBio Antibodies in human, mouse, rat for NR2F6

    NR2F6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NR2F6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NR2F6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NR2F6
    Cloud-Clone Corp. CLIAs for NR2F6
    Search eBioscience for ELISAs for NR2F6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: V-erbA-related gene
    2F. COUP-TF-like receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR003068 COUP_TF

    Graphical View of Domain Structure for InterPro Entry P10588

    ProtoNet protein and cluster: P10588

    3 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003068 COUP transcription factor (2F nuclear receptor) family signature
    IPB013629 Zinc finger


    UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with NR2F6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR2F6_HUMAN, P10588
    Function: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer
    response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which
    are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses
    transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and
    the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional
    activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards
    thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine
    response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its
    transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T
    cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity.
    Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus
    (LC)
    Induction: Inhibited by gonadotropin in granulosa cells

         Genatlas biochemistry entry for NR2F6:
    nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS2905047
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10644740
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS2905047
    GO:0004887thyroid hormone receptor activity TAS2905047
         
    Find genes that share ontologies with NR2F6           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nr2f6):
     behavior/neurological  integument  nervous system 

    Find genes that share phenotypes with NR2F6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nr2f6tm1Ge for NR2F6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR2F6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NR2F6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR2F6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR2F6

    miRNA
    Products:
        
    miRTarBase miRNAs that target NR2F6:
    hsa-mir-98-5p (MIRT027803), hsa-mir-346 (MIRT004232), hsa-mir-196a-5p (MIRT048210), hsa-mir-30a-5p (MIRT049946), hsa-mir-335-5p (MIRT018838), hsa-mir-30d-5p (MIRT047809)

    Block miRNA regulation of human, mouse, rat NR2F6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR2F6 (see all 9):
    hsa-miR-142-3p hsa-miR-433 hsa-miR-198 hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidNR2F6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NR2F6
    Predesigned siRNA for gene silencing in human, mouse, rat NR2F6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NR2F6

    Clone
    Products:
         
    OriGene clones in human, mouse for NR2F6 (see all 7)
    OriGene ORF clones in mouse, rat for NR2F6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NR2F6 (NM_005234)
    Sino Biological Human cDNA Clone for NR2F6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR2F6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2F6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NR2F6
    Browse ESI BIO Cell Lines and PureStem Progenitors for NR2F6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2F6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NR2F6_HUMAN, P10588: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10644740
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with NR2F6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NR2F6 About    
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with NR2F6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NR2F6
        Nuclear Receptors


    1 Reactome Pathway for NR2F6
        Nuclear Receptor transcription pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR2F6: 
              Estrogen Receptor Signaling in human mouse rat
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR2F6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NR2F6 (P105881, 2, 3 ENSP000002914424) via UniProtKB, MINT, STRING, and/or I2D (see all 641)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR2F2P244682, 3MINT-7945693 I2D: score=4 
    CBX1P839161, 3EBI-2681496,EBI-78129 I2D: score=1 
    NAP1L1P552091, 3EBI-2681496,EBI-356392 I2D: score=1 
    RBMXP381592, 3MINT-7945693 I2D: score=1 
    NR3C1P041503, ENSP000002315094I2D: score=4 STRING: ENSP00000231509
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10644740
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007165signal transduction TAS2905047
    GO:0010467gene expression TAS--

    Find genes that share ontologies with NR2F6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NR2F6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NR2F6 gene: 
    NM_005234.3  

    Unigene Cluster for NR2F6:

    Nuclear receptor subfamily 2, group F, member 6
    Hs.466148  [show with all ESTs]
    Unigene Representative Sequence: BC002669
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291442(uc002nfq.3) ENST00000596878
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NR2F6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR2F6 (see all 9):
    hsa-miR-142-3p hsa-miR-433 hsa-miR-198 hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidNR2F6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NR2F6
    Predesigned siRNA for gene silencing in human, mouse, rat NR2F6
    Clone
    Products:
         
    OriGene clones in human, mouse for NR2F6 (see all 7)
    OriGene ORF clones in mouse, rat for NR2F6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NR2F6 (NM_005234)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR2F6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2F6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NR2F6
    OriGene qSTAR qPCR primer pairs in human, mouse for NR2F6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR2F6
      QuantiTect SYBR Green Assays in human, mouse, rat NR2F6
      QuantiFast Probe-based Assays in human, mouse, rat NR2F6

    Additional mRNA sequence: 

    AB307712.1 AK298764.1 AK314961.1 BC002669.2 BC063018.1 BC084544.1 HQ692851.1 

    10 DOTS entries:

    DT.97857739  DT.85102327  DT.100814198  DT.91761109  DT.95270826  DT.121502634  DT.121502680  DT.121502720 
    DT.121502725  DT.95249903 

    Selected AceView cDNA sequences (see all 286):

    CR597276 BF111625 BF115666 AA186362 AI869260 BU733123 CA447186 BE222650 
    BE742614 BQ575213 AW512691 AA147931 BX107591 BF515865 AW006013 AI910998 
    CA422903 T19367 BF515310 AI123728 AI523767 AW044448 BM766606 AI369183 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NR2F6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGACTCAAG
    NR2F6 Expression
    About this image


    NR2F6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Lens
     
     Placenta (Extraembryonic Tissues)
    NR2F6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR2F6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466148

    UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588
    Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR2F6: 
              Estrogen Receptor Signaling in human mouse rat
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NR2F6
    OriGene qSTAR qPCR primer pairs in human, mouse for NR2F6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR2F6
    QuantiTect SYBR Green Assays in human, mouse, rat NR2F6
    QuantiFast Probe-based Assays in human, mouse, rat NR2F6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2F6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NR2F6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr2f61 , 5 nuclear receptor subfamily 2, group F, member 61, 5 87.06(n)1
    93.83(a)1
      8 (34.43 cM)5
    138641  NM_010150.21  NP_034280.21 
     713741235 
    chicken
    (Gallus gallus)
    Aves NR2F66
    nuclear receptor subfamily 2, group F, member 6
    81(a)
    1 ↔ 1
    JH375547.1(159-2185)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    65(a)
    many ↔ many
    GL343668.1(302865-305710)
    African clawed frog
    (Xenopus laevis)
    Amphibia nr2f6-prov2 nuclear receptor subfamily 2, group F, member 6 76.3(n)    BC056043.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr2f6a1 nuclear receptor subfamily 2, group F, member 6a 71.91(n)
    77.41(a)
      325637  NM_205557.1  NP_991120.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-553 nuclear hormone receptor 34(a)   I(7907104-7911844)   --


    ENSEMBL Gene Tree for NR2F6 (if available)
    TreeFam Gene Tree for NR2F6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NR2F6 gene
    RXRA2  RXRG2  NR2F12  NR2F22  HNF4G2  NR2C12  NR2E12  HNF4A2  
    RXRB2  NR2C22  
    Selected SIMAP similar genes for NR2F6 using alignment to 4 protein entries:     NR2F6_HUMAN (see all proteins) (see all similar genes):
    NR3C2    NR5A1    ESR1    NR2F2    NR2F1    RORA
    HNF4alpha    VDR    PPARG    HNF4G    DKFZp779O0162    NR2B1
    RXRA    NR1I3    NR2A2    NR2A3    NR2B3    RXRB

    Find genes that share paralogs with NR2F6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NR2F6 (see all 347)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829797171,2
    --17289921(+) TTCCCA/GAGGTC 1 -- us2k10--------
    rs730125901,2
    C,F--17289932(+) TAGAGT/ACGGGT 1 -- us2k13Minor allele frequency- A:0.19CSA WA NA 240
    rs349634251,2
    C,F--17289933(+) AGAGTC/AGGGTT 1 -- us2k13Minor allele frequency- A:0.19CSA WA NA 240
    rs1132262661,2
    C,F--17289942(+) TTCTGC/TCCACA 1 -- us2k12Minor allele frequency- T:0.05WA 120
    rs1857643761,2
    --17289948(+) CCACAA/GCCTGA 1 -- us2k10--------
    rs1484514201,2
    --17289987(+) GTGGGG/TGGGCA 1 -- us2k10--------
    rs1910795781,2
    --17290044(+) TTTGGA/GATGAG 1 -- us2k10--------
    rs779126221,2
    C--17290136(+) AAAAGA/CGATTT 1 -- us2k10--------
    rs1828735571,2
    --17290175(+) CCTGTA/GATCCC 1 -- us2k10--------
    rs1472064551,2
    --17290176(+) CTGTAA/GTCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NR2F6 (17342692 - 17356749 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NR2F6 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3760n71CNV Loss21882294
    nsv911182CNV Loss21882294
    dgv3756n71CNV Loss21882294
    esv29611CNV Loss19812545
    dgv3757n71CNV Loss21882294
    nsv911188CNV Loss21882294
    nsv911189CNV Loss21882294
    nsv911185CNV Loss21882294
    nsv470129CNV Loss18288195
    dgv3759n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR2F6
    DNA2.0 Custom Variant and Variant Library Synthesis for NR2F6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 132880    OMIM disorders: --

    1 disease for NR2F6:    
    About MalaCards
    chronic purulent otitis media

    1 disease from the University of Copenhagen DISEASES database for NR2F6:
    Chronic purulent otitis media

    Find genes that share disorders with NR2F6           About GenesLikeMe


    Export disorders for NR2F6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NR2F6 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with NR2F6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PubMed id 2905047)1, 2, 3 Miyajima N.... Yamamoto T. (Nucleic Acids Res. 1988)
    2. The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. (PubMed id 10713182)1, 2, 9 Zhu X.G.... Cheng S.Y. (Mol. Cell. Biol. 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PubMed id 10644740)1, 2 Zhang Y. and Dufau M.L. (J. Biol. Chem. 2000)
    5. EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. (PubMed id 11682620)2, 9 Zhang Y. and Dufau M.L. (Mol. Endocrinol. 2001)
    6. A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. (PubMed id 23975195)1 Chan C.M....Heery D.M. (Nucleic Acids Res. 2013)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells. (PubMed id 21696885)1 Li X.B....Fang J. (Cancer Lett. 2011)
    10. Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription. (PubMed id 21247419)1 Tan J.J....Chen K.S. (BMC Mol. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2063 HGNC: 7977 AceView: NR2F6 Ensembl:ENSG00000160113 euGenes: HUgn2063
    ECgene: NR2F6 H-InvDB: NR2F6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NR2F6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NR2F6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NR2F6 gene:
    Search GeneIP for patents involving NR2F6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NR2F6 (EAR2/NR2F6)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NR2F6   OriGene RNAi products in human, mouse, rat for NR2F6  
     OriGene qPCR primer pairs and template standards for NR2F6   OriGene Protein Over-expression Lysate for NR2F6  
     OriGene MassSpec something-or-other for NR2F6   OriGene clones in human, mouse for NR2F6  
     OriGene qSTAR qPCR primer pairs in human, mouse for NR2F6   OriGene Purified Protein for NR2F6  
     OriGene ORF clones in mouse, rat for NR2F6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NR2F6   OriGene Custom Protein Services for NR2F6  

     
     
     Block miRNA regulation of human, mouse, rat NR2F6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NR2F6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR2F6 Predesigned siRNA for gene silencing in human, mouse, rat NR2F6
     QuantiFast Probe-based Assays in human, mouse, rat NR2F6 QuantiTect SYBR Green Assays in human, mouse, rat NR2F6
     PCR Arrays including human, mouse, rat NR2F6 Search Chromatin IP Primers for NR2F6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR2F6  GeneGlobe Interaction Network for NR2F6
     Regulatory tfbs in NR2F6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NR2F6 GenScript cDNA clones with any tag delivered in your preferred vector for NR2F6
     GenScript Custom Assay Services for NR2F6 GenScript Custom overexpressing Cell Line Services for NR2F6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NR2F6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NR2F6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NR2F6 antibodies
     NR2F6 proteins
     NR2F6 lysates
     Antibodies for NR2F6
     See all of Abcam's Antibodies, Kits and Proteins for NR2F6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NR2F6
     Antibodies for NR2F6
     ELISAs for NR2F6
     CLIAs for NR2F6



     Browse ESI BIO Cell Lines and PureStem Progenitors for NR2F6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2F6
     SwitchGear 3'UTR luciferase reporter plasmids for NR2F6
     SwitchGear Promoter luciferase reporter plasmids for NR2F6
     ThermoFisher Antibodies for NR2F6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2F6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR2F6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NR2F6
     LSBio Antibodies in human, mouse, rat for NR2F6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NR2F6
      Search eBioscience for proteins for NR2F6
      Search eBioscience for elisas for NR2F6
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NR2F6 gene at Home site.
    Version: 3.12.216 30 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4