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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR2F6 Gene

protein-coding   GIFtS: 60
GCID: GC19M017342

nuclear receptor subfamily 2, group F, member 6


(Previous symbol: ERBAL2)
 Explore 8 diseases affiliated with
NR2F6 via our new
 Human Malady Compendium 
Biological research products
for NR2F6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 2, Group F, Member 61 2     ERBA-Related Gene-22
ERBAL21 2 3 5     Nuclear Receptor Subfamily 2 Group F Member 62
EAR-21 2 3     Nuclear Receptor V-ErbA-Related2
EAR22 3 5     V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 22
V-ErbA-Related Protein 22 3     

External Ids:    HGNC: 79771   Entrez Gene: 20632   Ensembl: ENSG000001601137   OMIM: 1328805   UniProtKB: P105883   

Export aliases for NR2F6 gene to outside databases

Previous GC identifers: GC19M017836 GC19M017734 GC19M017187 GC19M017203 GC19M016910


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588
Function: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer
response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are
also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses
transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the
oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of
the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone
receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements
(TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts
as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in
induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of
forebrain circadian clock; is required early in the development of the locus coeruleus (LC)

Gene Wiki entry for NR2F6 (V-erbA-related gene)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR2F6 gene promoter:
         TBP   CREB   deltaCREB   NF-kappaB1   NF-kappaB   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNR2F6 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR2F6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2F6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC chromosome: 19

NR2F6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2F6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017342:  view genomic region     (about GC identifiers)

Start:
17,342,694 bp from pter      End:
17,356,151 bp from pter
Size:
13,458 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 2 group F member 6  
Size: 404 amino acids; 42979 Da
Subunit: Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1 (By similarity). Interacts with
THRB
Subcellular location: Nucleus
Secondary accessions: B2RC68 Q5XGA0 Q6P586 Q9BUE8

Explore the universe of human proteins at neXtProt for NR2F6: NX_P10588

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P10588

  • NR2F6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005225.2  
    ENSEMBL proteins: 
     ENSP00000291442  
    Reactome Protein details: P10588
    Human Recombinant Protein Products: 
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    Novus Biologicals NR2F6 Protein
    Novus Biologicals NR2F6 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NR2F6

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10644740
    GO:0005654nucleoplasm TAS--


    NR2F6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NR2F6


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NR2F6 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR003068 COUP_TF

    Graphical View of Domain Structure for InterPro Entry P10588

    ProtoNet protein and cluster: P10588

    3 Blocks protein families:
    IPB001723 Steroid hormone receptor signature
    IPB003068 COUP transcription factor (2F nuclear receptor) family signature
    IPB013629 Zinc finger


    UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588
    Function: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer
    response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are
    also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses
    transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the
    oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of
    the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone
    receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements
    (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts
    as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in
    induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of
    forebrain circadian clock; is required early in the development of the locus coeruleus (LC)
    Induction: Inhibited by gonadotropin in granulosa cells

         Genatlas biochemistry entry for NR2F6:
    nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NR2F6 (see all 9):
    hsa-miR-142-3p hsa-miR-433 hsa-miR-198 hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidNR2F6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR2F6 (see all 6)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR2F6

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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS2905047
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10644740
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS2905047
    GO:0004887thyroid hormone receptor activity TAS2905047


    NR2F6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Nr2f6tm1Ge for NR2F6
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nr2f6):
     behavior/neurological  integument  nervous system 

    NR2F6 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46
    2Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway1.00
    Nuclear Receptors0.68

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for NR2F6 
        Nuclear Receptors

    3        Reactome Pathways for NR2F6
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression



    NR2F6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR2F6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/614 Interacting proteins for NR2F6 (P105881, 2, 3 ENSP000002914424) via UniProtKB, MINT, STRING, and/or I2D (see all 614)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR2F2P244682, 3MINT-7945693 I2D: score=4 
    CBX1P839161, 3EBI-2681496,EBI-78129 I2D: score=1 
    NAP1L1P552091, 3EBI-2681496,EBI-356392 I2D: score=1 
    RBMXP381592, 3MINT-7945693 I2D: score=1 
    NR3C1P041503, ENSP000002315094I2D: score=4 STRING: ENSP00000231509
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10644740
    GO:0006351transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007165signal transduction TAS2905047
    GO:0010467gene expression TAS--


    NR2F6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR2F6
    Search CenterWatch for drugs/clinical trials and news about NR2F6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NR2F6 gene: 
    NM_005234.3  

    Unigene Cluster for NR2F6:

    Nuclear receptor subfamily 2, group F, member 6
    Hs.466148  [show with all ESTs]
    Unigene Representative Sequence: BC002669
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000291442(uc002nfq.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NR2F6
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NR2F6 (see all 9):
    hsa-miR-142-3p hsa-miR-433 hsa-miR-198 hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidNR2F6 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR2F6 (see all 6)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR2F6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR2F6

    Additional cDNA sequence: 

    AB307712.1 AK298764.1 AK314961.1 BC002669.2 BC063018.1 BC084544.1 HQ692851.1 

    10 DOTS entries:

    DT.97857739  DT.85102327  DT.100814198  DT.91761109  DT.95270826  DT.121502634  DT.121502680  DT.121502720 
    DT.121502725  DT.95249903 

    24/286 AceView cDNA sequences (see all 286):

    BE552477 BX107591 H20096 BM915376 AA147502 AA147931 BQ581683 BM555019 
    AI146583 AI369183 T19366 BG830676 CA447186 NM_005234 AW628392 BC002669 
    BM683296 CR597276 AI830334 AI123728 BF111625 BF516390 AI910998 CA391292 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR2F6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGACTCAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NR2F6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR2F6

    SOURCE GeneReport for Unigene cluster: Hs.466148

    UniProtKB/Swiss-Prot: NR2F6_HUMAN, P10588
    Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Arrays including NR2F6: 
              Estrogen Receptor Signaling in human mouse rat
              Circadian Rhythms in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NR2F6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NR2F6 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    African clawed frog
    (Xenopus laevis)
    Amphibia nr2f6-prov2 nuclear receptor subfamily 2, group F, member 6 76.3(n)    BC056043.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr2f6a1 nuclear receptor subfamily 2, group F, member 6a 72.34(n)
    78.17(a)
      325637  NM_205557.1  NP_991120.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-553 nuclear hormone receptor 34(a)   I(7907104-7911844)   --


    ENSEMBL Gene Tree for NR2F6 (if available)
    TreeFam Gene Tree for NR2F6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR2F6 gene
    ESRRA2  RXRG2  PGR2  ESR22  ESRRB2  HNF4G2  NR2E12  ESRRG2  
    NR3C22  RXRA2  NR2F12  NR3C12  NR2F22  AR2  ESR12  NR2C12  
    HNF4A2  NR2C22  RXRB2  
    18/39 SIMAP similar genes for NR2F6 using alignment to 4 protein entries:     NR2F6_HUMAN (see all proteins) (see all similar genes):
    NR3C2    NR5A1    NR2F1    ESR1    NR2F2    RORA
    HNF4alpha    VDR    PPARA    PPARG    HNF4G    DKFZp779O0162
    NR2B1    RXRA    NR1I3    NR2A2    NR2A3    NR2B3

    NR2F6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 NCBI SNPs in NR2F6 are shown (see all 249    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1816484301,2
    --17342200(+) GGTGCA/GCACCT 1 -- ds50010--------
    rs609609681,2
    C,--17342284(+) AGATTG/ACACCA 1 -- ds50012Minor allele frequency- A:0.14CSA EA 121
    rs10781271,2
    C,A,--17342315(+) AACAGC/TGAAAC 1 -- ds50014Minor allele frequency- T:0.19NA WA EA 360
    rs7510101,2
    C,F,A,--17342316(+) acagcG/Aaaact 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1473281991,2
    --17342405(+) GCTCAC/TGCTTG 1 -- ds50010--------
    rs1867164941,2
    --17342459(+) AGTTCG/TAGACC 1 -- ds50010--------
    rs116722951,2
    H--17342481(+) catggG/Tgaaac 1 -- ds50010--------
    rs1449226361,2
    --17342522(+) GCATCA/GTGGTG 1 -- ds50010--------
    rs621262221,2
    C,--17342568(+) CAGGAC/GAATCG 1 -- ds50011Minor allele frequency- G:0.00WA 2
    rs20146861,2
    C,F,H,--17342664(+) AAAATA/GAAAAA 1 -- ds500118Minor allele frequency- G:0.18NS EA NA WA 2342

    HapMap Linkage Disequilibrium report for NR2F6 (17342694 - 17356151 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for NR2F6
         2 CNVs: 73321 30072

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NR2F6 for disorders           About GeneDecksing

    OMIM gene information: 132880    OMIM disorders: --

    8 diseases for NR2F6:    About MalaCards
    chronic purulent otitis media    otitis media    leukemia    colon cancer
    colorectal cancer    immunodeficiency    thyroiditis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NR2F6:
    Chronic purulent otitis media

    Export disorders for NR2F6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR2F6 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with NR2F6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PubMed id 2905047)1, 2, 3 Miyajima N.... Yamamoto T. (1988)
    2. The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. (PubMed id 10713182)1, 2, 9 Zhu X.G....Cheng S.Y. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PubMed id 10644740)1, 2 Zhang Y. and Dufau M.L. (2000)
    5. EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. (PubMed id 11682620)2, 9 Zhang Y. and Dufau M.L. (2001)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells. (PubMed id 21696885)1 Li X.B....Fang J. (2011)
    8. Rasd1 interacts with Ear2 (Nr2f6) to regulate renin t ranscription. (PubMed id 21247419)1 Tan J.J....Chen K.S. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Complementary quantitative proteomics reveals that tr anscription factor AP-4 mediates E-box-dependent complex formation for transcri ptional repression of HDM2. (PubMed id 19505873)1 Ku W.C....Chen Y.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2063 HGNC: 7977 AceView: NR2F6 Ensembl:ENSG00000160113 euGenes: HUgn2063
    ECgene: NR2F6 H-InvDB: NR2F6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR2F6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NR2F6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NR2F6 gene:
    Search GeneIP for patents involving NR2F6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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