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Aliases for NR2F6 Gene

Aliases for NR2F6 Gene

  • Nuclear Receptor Subfamily 2 Group F Member 6 2 3 5
  • V-ErbA-Related Protein 2 3 4
  • ERBAL2 3 4
  • EAR-2 3 4
  • EAR2 3 4
  • V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 2 3
  • Nuclear Receptor Subfamily 2, Group F, Member 6 2
  • Nuclear Receptor V-ErbA-Related 3
  • ERBA-Related Gene-2 3

External Ids for NR2F6 Gene

Previous HGNC Symbols for NR2F6 Gene

  • ERBAL2

Previous GeneCards Identifiers for NR2F6 Gene

  • GC19M017836
  • GC19M017734
  • GC19M017187
  • GC19M017203
  • GC19M017342
  • GC19M016910

Summaries for NR2F6 Gene

GeneCards Summary for NR2F6 Gene

NR2F6 (Nuclear Receptor Subfamily 2 Group F Member 6) is a Protein Coding gene. Among its related pathways are Circadian rythm related genes and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is NR2F1.

UniProtKB/Swiss-Prot for NR2F6 Gene

  • Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

Gene Wiki entry for NR2F6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2F6 Gene

Genomics for NR2F6 Gene

Regulatory Elements for NR2F6 Gene

Enhancers for NR2F6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G017239 1.4 ENCODE dbSUPER 18.4 +0.9 924 10.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF263 TBX21 MEF2D SSRP1 GLIS1 MVB12A NR2F6 ENSG00000267904 ENSG00000268087 OCEL1 ENSG00000269578 BST2 CPAMD8 RPL18A GTPBP3
GH19G017234 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +10.1 10083 3.2 HDGF PKNOX1 ARNT CREB3L1 AGO1 SIN3A ZNF2 YY1 ZNF766 ZNF143 OCEL1 NR2F6 MVB12A BST2 GTPBP3 GC19M017243
GH19G017336 1.4 ENCODE dbSUPER 11.2 -91.4 -91416 2.5 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC ENSG00000269578 MVB12A ENSG00000268743 C19orf44 MRPL34 PLVAP COLGALT1 ENSG00000268087 ABHD8 ENSG00000267904
GH19G017170 1.1 ENCODE dbSUPER 11.9 +75.0 75045 0.2 TAL1 BACH1 RELA ZNF664 TCF12 ZNF121 ARID3A POLR2A NCOR1 ZNF207 NR2F6 CPAMD8 ENSG00000268056 ENSG00000269836
GH19G017159 1 ENCODE dbSUPER 11.5 +86.1 86071 1.1 SAP130 TEAD4 MAX ARID4B EBF1 RAD21 ZBTB40 RARA ZNF7 POLR2A MYO9B NR2F6 CPAMD8 ENSG00000268056 GC19M017123
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NR2F6 on UCSC Golden Path with GeneCards custom track

Promoters for NR2F6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107863 142 3201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 SP5 MXD4 SMARCB1

Genomic Location for NR2F6 Gene

Chromosome:
19
Start:
17,231,883 bp from pter
End:
17,245,940 bp from pter
Size:
14,058 bases
Orientation:
Minus strand

Genomic View for NR2F6 Gene

Genes around NR2F6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR2F6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR2F6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2F6 Gene

Proteins for NR2F6 Gene

  • Protein details for NR2F6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10588-NR2F6_HUMAN
    Recommended name:
    Nuclear receptor subfamily 2 group F member 6
    Protein Accession:
    P10588
    Secondary Accessions:
    • B2RC68
    • Q5XGA0
    • Q6P586
    • Q9BUE8

    Protein attributes for NR2F6 Gene

    Size:
    404 amino acids
    Molecular mass:
    42979 Da
    Quaternary structure:
    • Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1 (By similarity). Interacts with THRB.

neXtProt entry for NR2F6 Gene

Post-translational modifications for NR2F6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR2F6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NR2F6 Gene

Domains & Families for NR2F6 Gene

Gene Families for NR2F6 Gene

Graphical View of Domain Structure for InterPro Entry

P10588

UniProtKB/Swiss-Prot:

NR2F6_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with NR2F6: view

Function for NR2F6 Gene

Molecular function for NR2F6 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 2,group F,member 6,steroid/thyroid receptor superfamily
UniProtKB/Swiss-Prot Function:
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5-AGGTCA-3 direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
UniProtKB/Swiss-Prot Induction:
Inhibited by gonadotropin in granulosa cells.

Gene Ontology (GO) - Molecular Function for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IEA,TAS 2905047
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 10644740
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with NR2F6: view
genes like me logo Genes that share phenotypes with NR2F6: view

Animal Models for NR2F6 Gene

MGI Knock Outs for NR2F6:

Animal Model Products

CRISPR Products

miRNA for NR2F6 Gene

miRTarBase miRNAs that target NR2F6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NR2F6 Gene

Localization for NR2F6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2F6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NR2F6 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10644740
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with NR2F6: view

Pathways & Interactions for NR2F6 Gene

genes like me logo Genes that share pathways with NR2F6: view

Pathways by source for NR2F6 Gene

SIGNOR curated interactions for NR2F6 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NR2F6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10644740
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007165 signal transduction TAS 2905047
genes like me logo Genes that share ontologies with NR2F6: view

Transcripts for NR2F6 Gene

mRNA/cDNA for NR2F6 Gene

Unigene Clusters for NR2F6 Gene

Nuclear receptor subfamily 2, group F, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR2F6 Gene

No ASD Table

Relevant External Links for NR2F6 Gene

GeneLoc Exon Structure for
NR2F6
ECgene alternative splicing isoforms for
NR2F6

Expression for NR2F6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NR2F6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR2F6 Gene

This gene is overexpressed in Liver (x4.3).

Protein differential expression in normal tissues from HIPED for NR2F6 Gene

This gene is overexpressed in Breast (51.5) and Retina (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NR2F6 Gene



NURSA nuclear receptor signaling pathways regulating expression of NR2F6 Gene:

NR2F6

SOURCE GeneReport for Unigene cluster for NR2F6 Gene:

Hs.466148

mRNA Expression by UniProt/SwissProt for NR2F6 Gene:

P10588-NR2F6_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for NR2F6 Gene

  • Lung(4.5)
  • Liver(4.4)
  • Kidney(4.3)
  • Pancreas(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with NR2F6: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NR2F6 Gene

Orthologs for NR2F6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2F6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2F6 34 35
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia NR2F6 34 35
  • 94.19 (n)
cow
(Bos Taurus)
Mammalia NR2F6 34 35
  • 92.29 (n)
mouse
(Mus musculus)
Mammalia Nr2f6 34 16 35
  • 87.06 (n)
rat
(Rattus norvegicus)
Mammalia Nr2f6 34
  • 87.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NR2F6 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2F6 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR2F6 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nr2f6 34
  • 70.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia nr2f6-prov 34
zebrafish
(Danio rerio)
Actinopterygii nr2f6b 35
  • 75 (a)
OneToMany
nr2f6a 34 35
  • 71.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta dsf 36
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-55 36 35
  • 34 (a)
Species where no ortholog for NR2F6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2F6 Gene

ENSEMBL:
Gene Tree for NR2F6 (if available)
TreeFam:
Gene Tree for NR2F6 (if available)

Paralogs for NR2F6 Gene

Paralogs for NR2F6 Gene

genes like me logo Genes that share paralogs with NR2F6: view

Variants for NR2F6 Gene

Sequence variations from dbSNP and Humsavar for NR2F6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000144965 -- 17,246,105(+) CGCGG(C/G)GCCTG upstream-variant-2KB
rs1000229357 -- 17,232,278(+) GCCCC(A/T)CGAGG utr-variant-3-prime
rs1000298473 -- 17,237,414(+) CCCTC(C/T)CTCTC intron-variant
rs1000412418 -- 17,237,569(+) ACCAC(A/G)CCTGG intron-variant
rs1000622758 -- 17,236,324(+) GTAGG(A/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NR2F6 Gene

Variant ID Type Subtype PubMed ID
esv29611 CNV loss 19812545
nsv1071513 CNV deletion 25765185
nsv1118819 CNV deletion 24896259
nsv1118820 CNV deletion 24896259
nsv470129 CNV loss 18288195

Variation tolerance for NR2F6 Gene

Gene Damage Index Score: 2.23; 40.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NR2F6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR2F6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F6 Gene

Disorders for NR2F6 Gene

Relevant External Links for NR2F6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR2F6

No disorders were found for NR2F6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NR2F6 Gene

Publications for NR2F6 Gene

  1. The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. (PMID: 10713182) Zhu X.G. … Cheng S.Y. (Mol. Cell. Biol. 2000) 3 4 22 64
  2. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PMID: 2905047) Miyajima N. … Yamamoto T. (Nucleic Acids Res. 1988) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. (PMID: 11682620) Zhang Y. … Dufau M.L. (Mol. Endocrinol. 2001) 4 22 64
  5. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PMID: 10644740) Zhang Y. … Dufau M.L. (J. Biol. Chem. 2000) 3 4 64

Products for NR2F6 Gene

Sources for NR2F6 Gene

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