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Aliases for NR2F2 Gene

Aliases for NR2F2 Gene

  • Nuclear Receptor Subfamily 2, Group F, Member 2 2 3
  • TFCOUP2 3 4 6
  • Arp1 3 4 6
  • Apolipoprotein A-I Regulatory Protein 1 3 4
  • COUP Transcription Factor II 3 4
  • Chicken Ovalbumin Upstream Promoter Transcription Factor 2 3
  • Chicken Ovalbumin Upstream Promoter-Transcription Factor I 3
  • Nuclear Receptor Subfamily 2 Group F Member 2 4
  • ADP-Ribosylation Factor Related Protein 1 3
  • Apolipoprotein AI Regulatory Protein 1 3
  • COUP Transcription Factor 2 3
  • COUP-TF II 4
  • COUPTFII 3
  • COUP-TF2 4
  • COUPTFB 3
  • CHTD4 3
  • NF-E3 3
  • NR2F1 3
  • SVP40 3
  • ARP-1 4

External Ids for NR2F2 Gene

Previous HGNC Symbols for NR2F2 Gene

  • ARP1
  • TFCOUP2

Previous GeneCards Identifiers for NR2F2 Gene

  • GC15P093321
  • GC15P090625
  • GC15P094456
  • GC15P094603
  • GC15P094674
  • GC15P096869
  • GC15P072999

Summaries for NR2F2 Gene

Entrez Gene Summary for NR2F2 Gene

  • This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for NR2F2 Gene

NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2) is a Protein Coding gene. Diseases associated with NR2F2 include congenital heart defects, multiple types, 4 and complete atrioventricular canal. Among its related pathways are L1CAM interactions and Oct4 in Mammalian ESC Pluripotency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is RXRG.

UniProtKB/Swiss-Prot for NR2F2 Gene

  • Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.

Gene Wiki entry for NR2F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2F2 Gene

Genomics for NR2F2 Gene

Regulatory Elements for NR2F2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NR2F2 Gene

Start:
96,325,928 bp from pter
End:
96,340,263 bp from pter
Size:
14,336 bases
Orientation:
Plus strand

Genomic View for NR2F2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2F2 Gene

Proteins for NR2F2 Gene

  • Protein details for NR2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24468-COT2_HUMAN
    Recommended name:
    COUP transcription factor 2
    Protein Accession:
    P24468
    Secondary Accessions:
    • B4DQJ2
    • B6ZGU1
    • Q03754
    • Q3KQR7

    Protein attributes for NR2F2 Gene

    Size:
    414 amino acids
    Molecular mass:
    45571 Da
    Quaternary structure:
    • Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NR2F2 Gene

    Alternative splice isoforms for NR2F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2F2 Gene

Proteomics data for NR2F2 Gene at MOPED

Post-translational modifications for NR2F2 Gene

  • Ubiquitination at Lys301 and Lys362
  • Modification sites at PhosphoSitePlus

Other Protein References for NR2F2 Gene

Antibody Products

  • R&D Systems Antibodies for NR2F2 (COUP-TF II/NR2F2)
  • Cell Signaling Technology (CST) Antibodies for NR2F2 (NR2F2)

No data available for DME Specific Peptides for NR2F2 Gene

Domains for NR2F2 Gene

Gene Families for NR2F2 Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P24468

UniProtKB/Swiss-Prot:

COT2_HUMAN :
  • P24468
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with NR2F2: view

Function for NR2F2 Gene

Molecular function for NR2F2 Gene

GENATLAS Biochemistry: nuclear receptor subfamily 2,group F,member 2,negative post transcriptional regulator of MYOD1 function,may be required for angiogenesis and heart developpment, steroid/thyroid hormone receptor superfamily
UniProtKB/Swiss-Prot Function: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.

Gene Ontology (GO) - Molecular Function for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 18798693
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 9343308
GO:0003707 steroid hormone receptor activity IEA --
GO:0003714 transcription corepressor activity TAS 1899293
genes like me logo Genes that share ontologies with NR2F2: view
genes like me logo Genes that share phenotypes with NR2F2: view

Animal Models for NR2F2 Gene

MGI Knock Outs for NR2F2:

Animal Model Products

CRISPR Products

miRNA for NR2F2 Gene

Transcription Factor Targeting for NR2F2 Gene

Selected GeneGlobe predicted Target genes for NR2F2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NR2F2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for NR2F2 Gene

Localization for NR2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR2F2 Gene COMPARTMENTS Subcellular localization image for NR2F2 gene
Compartment Confidence
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19210544
genes like me logo Genes that share ontologies with NR2F2: view

Pathways for NR2F2 Gene

genes like me logo Genes that share pathways with NR2F2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9343308
GO:0001701 in utero embryonic development --
GO:0001764 neuron migration IEA --
GO:0001893 maternal placenta development IEA --
GO:0001937 negative regulation of endothelial cell proliferation IMP 19210544
genes like me logo Genes that share ontologies with NR2F2: view

Compounds for NR2F2 Gene

(9) Novoseek inferred chemical compound relationships for NR2F2 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 60.8 14
steroid 48.2 8
estrogen 32.8 7
cholesterol 22.5 2
progesterone 17.4 3
genes like me logo Genes that share compounds with NR2F2: view

Transcripts for NR2F2 Gene

Unigene Clusters for NR2F2 Gene

Nuclear receptor subfamily 2, group F, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NR2F2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR2F2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: - -
SP2:
SP3: -

Relevant External Links for NR2F2 Gene

GeneLoc Exon Structure for
NR2F2
ECgene alternative splicing isoforms for
NR2F2

Expression for NR2F2 Gene

mRNA expression in normal human tissues for NR2F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR2F2 Gene

This gene is overexpressed in Ovary (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NR2F2 Gene

SOURCE GeneReport for Unigene cluster for NR2F2 Gene Hs.347991

mRNA Expression by UniProt/SwissProt for NR2F2 Gene

P24468-COT2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with NR2F2: view

In Situ Assay Products

Orthologs for NR2F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2F2 35
  • 100 (n)
  • 100 (a)
NR2F2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NR2F2 35
  • 96.38 (n)
  • 99.76 (a)
NR2F2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR2F2 35
  • 96.22 (n)
  • 99.76 (a)
NR2F2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2f2 35
  • 95.33 (n)
  • 100 (a)
Nr2f2 16
Nr2f2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2F2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR2F2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr2f2 35
  • 95.01 (n)
  • 99.76 (a)
chicken
(Gallus gallus)
Aves NR2F2 35
  • 84.88 (n)
  • 94.63 (a)
NR2F2 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR2F2 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nr2f2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nr2f2 35
  • 80.15 (n)
  • 92.89 (a)
Str.11156 35
zebrafish
(Danio rerio)
Actinopterygii nr2f2 35
  • 77.32 (n)
  • 88.54 (a)
nr2f2 36
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002544 35
  • 76.92 (n)
  • 89.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hr51 36
  • 25 (a)
ManyToMany
svp 35
  • 73.72 (n)
  • 84.34 (a)
svp 37
  • 87 (a)
dsf 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-55 37
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9339 35
Species with no ortholog for NR2F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2F2 Gene

ENSEMBL:
Gene Tree for NR2F2 (if available)
TreeFam:
Gene Tree for NR2F2 (if available)

Paralogs for NR2F2 Gene

Paralogs for NR2F2 Gene

genes like me logo Genes that share paralogs with NR2F2: view

Variants for NR2F2 Gene

Sequence variations from dbSNP and Humsavar for NR2F2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1110442 -- 96,334,657(+) CTGGG(C/G)CCCAG intron-variant
rs1110443 -- 96,335,429(+) TTGAG(A/G/T)CAAAA intron-variant
rs1574570 -- 96,334,870(+) CCCCA(C/T)CTGCA intron-variant
rs1807198 -- 96,335,065(-) TCCTA(C/T)TGAGT intron-variant
rs2001191 -- 96,335,120(-) AGAAT(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NR2F2 Gene

Variant ID Type Subtype PubMed ID
dgv448n67 CNV Gain 20364138
nsv904532 CNV Loss 21882294
nsv827449 CNV Gain 20364138
nsv827450 CNV Gain 20364138
esv21861 CNV Loss 19812545

Relevant External Links for NR2F2 Gene

HapMap Linkage Disequilibrium report
NR2F2
Human Gene Mutation Database (HGMD)
NR2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F2 Gene

Disorders for NR2F2 Gene

UniProtKB/Swiss-Prot

COT2_HUMAN
  • Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779]: A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. {ECO:0000269 PubMed:24702954}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for NR2F2 Gene

(6) Novoseek inferred disease relationships for NR2F2 Gene

Disease -log(P) Hits PubMed IDs
endometriosis 47.8 2
carcinoma embryonal 43.5 1
breast cancer 3.82 10
ovarian cancer 0 1
adenoma 0 3

Relevant External Links for NR2F2

Genetic Association Database (GAD)
NR2F2
Human Genome Epidemiology (HuGE) Navigator
NR2F2
genes like me logo Genes that share disorders with NR2F2: view

Publications for NR2F2 Gene

  1. The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. (PMID: 9343308) Chu K. … Zingg H.H. (J. Mol. Endocrinol. 1997) 3 4 23
  2. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. (PMID: 1899293) Ladias J.A.A. … Karathanasis S.K. (Science 1991) 3 4 23
  3. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PMID: 8530078) Qiu Y. … Tsai S.Y. (Genomics 1995) 2 3 23
  4. Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. (PMID: 11544252) Liberati C. … Ronchi A. (J. Biol. Chem. 2001) 2 3 23
  5. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. (PMID: 18798693) Kruse S.W. … Xu H.E. (PLoS Biol. 2008) 3 4 23

Products for NR2F2 Gene

  • Addgene plasmids for NR2F2

Sources for NR2F2 Gene

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