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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR2F2 Gene

protein-coding   GIFtS: 62
GCID: GC15P096869

nuclear receptor subfamily 2, group F, member 2


(Previous symbols: ARP1, TFCOUP2)
 Explore 25 diseases affiliated with
NR2F2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NR2F2    

Aliases
for NR2F2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Receptor Subfamily 2, Group F, Member 21 2     Apolipoprotein AI Regulatory Protein 12
ARP11 2 3 5     Chicken Ovalbumin Upstream Promoter Transcription Factor 22
TFCOUP21 2 3 5     Chicken Ovalbumin Upstream Promoter-Transcription Factor I2
COUPTFB1 2     Chicken Ovalbumin Upstream Promoter-Transcription Factor II Variant 12
NF-E31 2     Chicken Ovalbumin Upstream Promoter-Transcription Factor II Variant 22
SVP401 2     Chicken Ovalbumin Upstream Promoter-Transcription Factor II Variant 32
Apolipoprotein A-I Regulatory Protein 12 3     COUP Transcription Factor 22
COUP Transcription Factor II2 3     ARP-13
COUP-TFII1     COUP-TF23
COUPTFII2     COUP-TF II3
NR2F12     Nuclear Receptor Subfamily 2 Group F Member 23
ADP-Ribosylation Factor Related Protein 12     

External Ids:    HGNC: 79761   Entrez Gene: 70262   Ensembl: ENSG000001855517   OMIM: 1077735   UniProtKB: P244683   

Export aliases for NR2F2 gene to outside databases

Previous GC identifers: GC15P093321 GC15P090625 GC15P094456 GC15P094603 GC15P094674 GC15P072999


Summaries
for NR2F2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NR2F2:
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a
ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing
results in multiple transcript variants. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: COT2_HUMAN, P24468
Function: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and
all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the
apolipoprotein A-I gene transcription. Binds to DNA site A

Gene Wiki entry for NR2F2 (COUP-TFII)


Genomic Views
for NR2F2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010274.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR2F2 gene promoter:
         MyoD   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): NR2F2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR2F2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26   Ensembl cytogenetic band:  15q26.2   HGNC cytogenetic band: 15q26

NR2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2F2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P096869:  view genomic region     (about GC identifiers)

Start:
 96,869,157 bp from pter      End:
 96,883,492 bp from pter
Size:
 14,336 bases      Orientation:
 plus strand

Proteins
for NR2F2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: COT2_HUMAN, P24468 (See protein sequence)
Recommended Name: COUP transcription factor 2  
Size: 414 amino acids; 45571 Da
Subunit: Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts
with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity)
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for NR2F2:
3CJW (3D)    
Secondary accessions: B4DQJ2 B6ZGU1 Q03754 Q3KQR7
Alternative splicing: 3 isoforms:  P24468-1   P24468-2   P24468-3   

Explore the universe of human proteins at neXtProt for NR2F2: NX_P24468

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P24468

    • NR2F2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138627.1  NP_001138628.1  NP_001138629.1  NP_066285.1  

    ENSEMBL proteins: 
     ENSP00000401674   ENSP00000377721   ENSP00000457112   ENSP00000389853   ENSP00000377726  

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    Uscn Proteins for NR2F2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19210544


    NR2F2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NR2F2

    Protein Domains /
    Families
    for NR2F2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NR2F2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR003068 COUP_TF

    Graphical View of Domain Structure for InterPro Entry P24468

    ProtoNet protein and cluster: P24468

    3 Blocks protein families:
    IPB001723 Steroid hormone receptor signature
    IPB003068 COUP transcription factor (2F nuclear receptor) family signature
    IPB013629 Zinc finger


    UniProtKB/Swiss-Prot: COT2_HUMAN, P24468
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Function
    for NR2F2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: COT2_HUMAN, P24468
    Function: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and
    all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the
    apolipoprotein A-I gene transcription. Binds to DNA site A

         Genatlas biochemistry entry for NR2F2:
    nuclear receptor subfamily 2,group F,member 2,negative post transcriptional regulator of MYOD1 function,may be required
    for angiogenesis and heart developpment, steroid/thyroid hormone receptor superfamily

    10/457 SABiosciences Target genes for NR2F2 (see all 457):
    AATF ACOT4 ACPT ADAMTSL5 ADH5 ADPRHL2 ADRA1B AMICA1 ANGPTL2 ANKRD11

    miRNA
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    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate NR2F2 (see all 93):
    hsa-miR-582-3p hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-3607-3p hsa-miR-300 hsa-miR-128 hsa-miR-30d
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    Inhib. RNA
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    OriGene shRNA RFP: NR2F2
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA18798693
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA9343308
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003714transcription corepressor activity TAS1899293


    NR2F2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NR2F2:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Nr2f2tm1Tsa for NR2F2
         14 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Nr2f2):
     cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  immune system  mortality/aging  muscle  nervous system 
     no phenotypic analysis  pigmentation  reproductive system  vision/eye 

    NR2F2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NR2F2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Oct4 in Mammalian ESC Pluripotency
    		Oct4 in Mammalian ESC Pluripotency1.00
    2FOXA1 transcription factor network
    		FOXA1 transcription factor network1.00
    3Regulation of Telomerase
    		Regulation of Telomerase1.00
    4Nuclear Receptor transcription pathway
    		Nuclear Receptors0.68

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for NR2F2
        Oct4 in Mammalian ESC Pluripotency

    3 BioSystems Pathways for NR2F2 
        Nuclear Receptors
    Regulation of Telomerase
    FOXA1 transcription factor network


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR2F2

    5/575 Interacting proteins for NR2F2 (P244682, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 575)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR2F6P105882, 3MINT-7945693 I2D: score=4 
    HDAC1Q135472, 3MINT-7945693 I2D: score=3 
    HIPK3Q9H4222, 3MINT-61738 I2D: score=3 
    SQSTM1Q135012, 3MINT-7945693 I2D: score=2 
    NCOR2Q9Y6182, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9343308
    GO:0001764neuron migration IEA--
    GO:0001893maternal placenta development IEA--
    GO:0001937negative regulation of endothelial cell proliferation IMP19210544
    GO:0001945lymph vessel development ----


    NR2F2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NR2F2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NR2F2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR2F2
    9 Novoseek chemical compound relationships for NR2F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 60.8 28 1321332 (4), 8288643 (3), 20386594 (3), 8175747 (1) (see all 7)
    steroid 48.2 9 1899293 (2), 1312668 (1), 7947324 (1), 7567979 (1) (see all 7)
    estrogen 32.8 10 10221773 (2), 10772965 (1), 17590085 (1), 19154418 (1) (see all 6)
    cholesterol 22.5 2 1899293 (1), 10627496 (1)
    progesterone 17.4 3 17590085 (3)
    chloramphenicol 9.06 3 8530390 (1), 9343308 (1)
    lipid 0 2 1899293 (1), 18765665 (1)
    glucose 0 8 19862665 (6), 18765665 (2)
    tyrosine 0 1 16815388 (1)

    Search CenterWatch for drugs/clinical trials and news about NR2F2 / COT2 

    Transcripts
    for NR2F2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NR2F2 gene (4 alternative transcripts): 
    NM_001145155.1  NM_001145156.1  NM_001145157.1  NM_021005.3  

    Unigene Clusters for NR2F2:

    Nuclear receptor subfamily 2, group F, member 2
    Hs.347991  [show with all ESTs], Hs.519445  [show with all ESTs]
    Unigene Representative Sequences: NM_021005, NM_005654
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421109 ENST00000394166(uc010uri.2) ENST00000559679 ENST00000453270
    ENST00000394171(uc002btp.3 uc010urj.2 uc010urk.2)

    miRNA
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    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate NR2F2 (see all 93):
    hsa-miR-582-3p hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-3607-3p hsa-miR-300 hsa-miR-128 hsa-miR-30d
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF087978.1 BC004154.2 BC017493.1 HQ709180.1 HQ709181.1 HQ709182.1 HQ709183.1 X16155.1 

    24/27 DOTS entries (see all 27):

    DT.86854402  DT.101981327  DT.102835104  DT.100827459  DT.121032729  DT.448656  DT.40247694  DT.209110 
    DT.121032835  DT.95323546  DT.100659900  DT.100827457  DT.102835101  DT.75109795  DT.100028492  DT.40203455 
    DT.75133849  DT.92430669  DT.99960896  DT.120887286  DT.120887299  DT.40118356  DT.75160199  DT.95078565 

    24/292 AceView cDNA sequences (see all 292):

    AF087993 AI420144 BX352896 AW628809 AA378155 AI217843 AA232737 CB135067 
    BQ003100 AI304889 BP363838 AI659017 CD515655 AI253215 BM683555 BM971054 
    CA449328 AI318417 BF516199 BC014664 AA340728 BM993514 AI347987 AI052320 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NR2F2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
    SP1:              -     -                     
    SP2:                                          
    SP3:                    -                     


    ECgene alternative splicing isoforms for NR2F2

    Expression
    for NR2F2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR2F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAATTTTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NR2F2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/33 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 33) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartCardinal VeinsVenous Endothelial CellsEndothelium
    HeartLeft AtriumCardiomyocytesMyocardium
    HeartRight AtriumCardiomyocytesMyocardium
    LymphLymphatic VesselsLymphatic Endothelial CellsEndothelium
    EyeOuter Nuclear LayerCone Precursor CellsPhotoreceptors, Retina
    EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor CellsRetinal Pigmented Epithelium
    KidneyBowman's CapsuleParietal Epithelial CellsKidney
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    KidneyComma-shaped BodyComma-shaped Body CellsKidney
    KidneyDistal TubuleDistal Tubule CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Optic cup (Generation of retina...)
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Endoderm progenitor-like cells (Generation and expan...)
    Posterior foregut-like cells (A scalable, suspensi...)

    See NR2F2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR2F2

    SOURCE GeneReport for Unigene clusters: Hs.347991 Hs.519445

    UniProtKB/Swiss-Prot: COT2_HUMAN, P24468
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including NR2F2: 
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              Stem Cell Transcription Factors in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for NR2F2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NR2F2 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NR2F21 nuclear receptor subfamily 2, group F, member 2 84.96(n)
    94.88(a)    		   386585  NM_204421.1  NP_989752.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NR2F26
    		 --
    		 75(a)
    		 1 ↔ 1
    		 GL343363.1(10058-25729)
    African clawed frog
    (Xenopus laevis)    		 Amphibia nr2f2-prov2 nuclear receptor subfamily 2, group F, member 2 81.36(n)    BC044975.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nr2f22 nuclear receptor subfamily 2, group F, member 2 80.79(n)   30424  NM_131183.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta svp1 , 3 cardioblast determination receptor3
    seven up1    		 87(a)
    (best of 2)3
    71.33(n)1
    81.61(a)1    		   87B53
    414911  NM_079601.21  NP_524325.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-553 nuclear hormone receptor 34(a)   I(7907104-7911844)   --


    ENSEMBL Gene Tree for NR2F2 (if available)
    TreeFam Gene Tree for NR2F2 (if available) 

    Paralogs
    for NR2F2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR2F2 gene
    ESRRA2  RXRG2  PGR2  ESR22  ESRRB2  HNF4G2  NR2F62  NR2E12  
    ESRRG2  NR3C22  RXRA2  NR2F12  NR3C12  AR2  ESR12  NR2C12  
    HNF4A2  NR2C22  RXRB2  
    18/26 SIMAP similar genes for NR2F2 using alignment to 3 protein entries:     COT2_HUMAN (see all proteins) (see all similar genes):
    NR2F1    NR2F6    RXRA    NR2B1    HNF4A    HNF4G
    NR2A2    NR2A3    RXRG    NR2A1    NR2B3    RXRB
    NR2E1    ESRRB    NR2E3    ERRgamma    NR2B2    NR3B3

    NR2F2 for paralogs           About GeneDecksing



    Genomic Variants
    for NR2F2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 NCBI SNPs in NR2F2 are shown (see all 227)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs80325591,2
    		C,F,H,--72998263(+) CCACCT/CTACCC 1 -- int112Minor allele frequency- C:0.07NS EA NA WA 1746
    rs785198461,2
    		F,--72998709(+) AGGAGC/TCTCAC 1 -- int12Minor allele frequency- T:0.14WA EA 238
    rs1116463561,2
    		--72998749(+) CAAACC/GGCAAG 1 -- int12Minor allele frequency- G:0.07CSA WA 120
    rs1115226491,2
    		--72999626(+) TATCGC/TCTATA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs793606891,2
    		F,--72999633(+) TATAGT/CTGTTG 1 -- int11Minor allele frequency- C:0.05WA 118
    rs734712801,2
    		C,F,--73000330(+) AACGTG/TTATGA 1 -- int13Minor allele frequency- T:0.10WA CSA 122
    rs734712831,2
    		C,--73000425(+) GTGGTA/GGGAGA 1 -- int13Minor allele frequency- G:0.08WA CSA 121
    rs37434631,2
    		H--73000673(-) GCAGAG/AGCAAA 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1136153701,2
    		C,--73001065(+) CACCTA/CTTCGC 1 -- nc-transcript-variant0--------
    rs23982601,2
    		C,F,A,H,--73001923(+) TTTTGC/TCCTTT 1 -- us2k1 trp311Minor allele frequency- T:0.22NS EA NA WA CSA 679

    HapMap Linkage Disequilibrium report for NR2F2 (96869157 - 96883492 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NR2F2
         1 CNV: 72367
    Human Gene Mutation Database (HGMD): NR2F2

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    Disorders / Diseases
    for NR2F2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NR2F2 for disorders           About GeneDecksing

    OMIM gene information: 107773    OMIM disorders: --

    20/25 diseases for NR2F2 (see all 25):    About MalaCards
    ring chromosome 15    ring chromosomes    retinol binding protein    maturity-onset diabetes of the young
    congenital diaphragmatic hernia    thyroiditis    glucocorticoid resistance    esophageal squamous cell carcinoma
    squamous cell carcinoma    hernia    endometriosis    ovarian endometriosis
    ovarian cancer    breast cancer    carcinoma    esophagitis
    lung carcinoma    breast carcinoma    colorectal cancer    cholesterol

    1 disease from the University of Copenhagen DISEASES database for NR2F2:
    Congenital diaphragmatic hernia

    6 Novoseek disease relationships for NR2F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometriosis 47.8 2 16815388 (2)
    carcinoma embryonal 43.5 1 7947324 (1)
    breast cancer 3.82 13 19154418 (3), 12525252 (2), 17047084 (2), 10772965 (2) (see all 5)
    ovarian cancer 0 1 15010821 (1)
    adenoma 0 7 10946877 (2), 12943735 (1)
    tumors 0 12 10946877 (2), 15824151 (2), 20364082 (1), 7567979 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: NR2F2 (9 documents)

    Export disorders for NR2F2 gene to outside databases

    Publications
    for NR2F2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR2F2 gene, integrated from 9 sources (see all 131):
    (articles sorted by number of sources associating them with NR2F2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. (PubMed id 11544252)1, 3, 9 Liberati C....Ronchi A. (2001)
    2. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. (PubMed id 1899293)1, 2, 9 Ladias J.A.A. and Karathanasis S.K. (1991)
    3. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. (PubMed id 18798693)1, 2, 9 Kruse S.W....Xu H.E. (2008)
    4. The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. (PubMed id 9343308)1, 2, 9 Chu K. and Zingg H.H. (1997)
    5. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PubMed id 8530078)1, 3, 9 Qiu Y....Tsai S.Y. (1995)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (PubMed id 10318855)1, 2 Avram D....Leid M. (1999)
    8. The COUP-TFs compose a family of functionally related transcription factors. (PubMed id 1820218)1, 2 Wang L.H.... Tsai M.J. (1991)
    9. Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer. (PubMed id 19082449)1, 9 Shin S.W....Park J.I. (2009)
    10. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. (PubMed id 1312668)1, 9 Mietus-Snyder M....Karathanasis S.K. (1992)

    External Searches for NR2F2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing NR2F2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7026 HGNC: 7976 AceView: NR2F2 Ensembl:ENSG00000185551 euGenes: HUgn7026
    ECgene: NR2F2 H-InvDB: NR2F2

    Other Databases showing NR2F2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NR2F2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR2F2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NR2F2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NR2F2 gene:
    Search GeneIP for patents involving NR2F2

    GeneCards and IP:
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