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Aliases for NR2F2 Gene

Aliases for NR2F2 Gene

  • Nuclear Receptor Subfamily 2 Group F Member 2 2 3 4 5
  • Apolipoprotein A-I Regulatory Protein 1 3 4
  • COUP Transcription Factor II 3 4
  • TFCOUP2 3 4
  • ARP1 3 4
  • Chicken Ovalbumin Upstream Promoter-Transcription Factor I 3
  • Chicken Ovalbumin Upstream Promoter Transcription Factor 2 3
  • Nuclear Receptor Subfamily 2, Group F, Member 2 2
  • ADP-Ribosylation Factor Related Protein 1 3
  • Apolipoprotein AI Regulatory Protein 1 3
  • COUP Transcription Factor 2 3
  • COUP-TF II 4
  • COUP-TF2 4
  • COUPTFII 3
  • COUPTFB 3
  • ARP-1 4
  • CHTD4 3
  • NF-E3 3
  • NR2F1 3
  • SVP40 3

External Ids for NR2F2 Gene

Previous HGNC Symbols for NR2F2 Gene

  • ARP1
  • TFCOUP2

Previous GeneCards Identifiers for NR2F2 Gene

  • GC15P093321
  • GC15P090625
  • GC15P094456
  • GC15P094603
  • GC15P094674
  • GC15P096869
  • GC15P072999

Summaries for NR2F2 Gene

Entrez Gene Summary for NR2F2 Gene

  • This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for NR2F2 Gene

NR2F2 (Nuclear Receptor Subfamily 2 Group F Member 2) is a Protein Coding gene. Diseases associated with NR2F2 include Congenital Heart Defects, Multiple Types, 4 and Complete Atrioventricular Canal. Among its related pathways are Oct4 in Mammalian ESC Pluripotency and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is NR2F1.

UniProtKB/Swiss-Prot for NR2F2 Gene

  • Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.

Gene Wiki entry for NR2F2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2F2 Gene

Genomics for NR2F2 Gene

Regulatory Elements for NR2F2 Gene

Enhancers for NR2F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F096319 2.7 FANTOM5 Ensembl ENCODE 17.4 +14.7 14704 41.9 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 NR2F2 ENSG00000259312 PGAM1P12 SPATA8-AS1 NR2F2-AS1 LINC00924 ENSG00000275322 GC15M096320
GH15F096284 1 Ensembl ENCODE 16.1 -40.1 -40123 2.8 L3MBTL2 BHLHE40 MAX ZFHX2 JUND ZNF157 GLIS1 FOS E2F6 MYC NR2F2 MIR1469 NR2F2-AS1 ENSG00000279645 GC15P096285
GH15F096272 1.3 Ensembl ENCODE 15.9 -50.5 -50486 6.1 HDGF PKNOX1 ATF1 ARNT CREB3L1 ELK1 GATA2 FOS KDM4B JUNB NR2F2 MIR1469 NR2F2-AS1 GC15P096285 GC15M096250
GH15F096363 0.6 ENCODE 11.7 +37.5 37499 0.3 CTCF RNF2 CBX2 NBN CTBP2 MIR1469 NR2F2 NR2F2-AS1 PIR46489 GC15M096366
GH15F096361 0.2 ENCODE 11.7 +36.1 36139 0.2 CBX8 PKNOX1 RNF2 SUZ12 CBX2 CTBP2 EZH2 NR2F2-AS1 MIR1469 NR2F2 PIR46489 GC15M096366
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NR2F2 on UCSC Golden Path with GeneCards custom track

Promoters for NR2F2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000414067 972 4601 PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 ZNF2 ZNF143 SP5 ZHX2 REST

Genomic Location for NR2F2 Gene

Chromosome:
15
Start:
96,325,928 bp from pter
End:
96,340,263 bp from pter
Size:
14,336 bases
Orientation:
Plus strand

Genomic View for NR2F2 Gene

Genes around NR2F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR2F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR2F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2F2 Gene

Proteins for NR2F2 Gene

  • Protein details for NR2F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24468-COT2_HUMAN
    Recommended name:
    COUP transcription factor 2
    Protein Accession:
    P24468
    Secondary Accessions:
    • B4DQJ2
    • B6ZGU1
    • Q03754
    • Q3KQR7

    Protein attributes for NR2F2 Gene

    Size:
    414 amino acids
    Molecular mass:
    45571 Da
    Quaternary structure:
    • Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).
    • Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NR2F2 Gene

    Alternative splice isoforms for NR2F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2F2 Gene

Post-translational modifications for NR2F2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NR2F2 Gene

Domains & Families for NR2F2 Gene

Gene Families for NR2F2 Gene

Graphical View of Domain Structure for InterPro Entry

P24468

UniProtKB/Swiss-Prot:

COT2_HUMAN :
  • Contains 1 nuclear receptor DNA-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with NR2F2: view

Function for NR2F2 Gene

Molecular function for NR2F2 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 2,group F,member 2,negative post transcriptional regulator of MYOD1 function,may be required for angiogenesis and heart developpment, steroid/thyroid hormone receptor superfamily
UniProtKB/Swiss-Prot Function:
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.

Gene Ontology (GO) - Molecular Function for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001972 retinoic acid binding IDA 18798693
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IDA 9343308
GO:0003707 steroid hormone receptor activity IEA --
GO:0003714 transcription corepressor activity TAS 1899293
genes like me logo Genes that share ontologies with NR2F2: view
genes like me logo Genes that share phenotypes with NR2F2: view

Human Phenotype Ontology for NR2F2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NR2F2 Gene

MGI Knock Outs for NR2F2:

Animal Model Products

miRNA for NR2F2 Gene

miRTarBase miRNAs that target NR2F2

Transcription Factor Targets for NR2F2 Gene

Selected GeneGlobe predicted Target genes for NR2F2
Targeted motifs for NR2F2 Gene
HOMER Transcription Factor Regulatory Elements motif NR2F2
  • Consensus sequence: AGRGGTCA Submotif: canonical Cell Type: Artia GEO ID: GSE46497

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for NR2F2 Gene

Localization for NR2F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2F2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR2F2 Gene COMPARTMENTS Subcellular localization image for NR2F2 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19210544
genes like me logo Genes that share ontologies with NR2F2: view

Pathways & Interactions for NR2F2 Gene

genes like me logo Genes that share pathways with NR2F2: view

Pathways by source for NR2F2 Gene

SIGNOR curated interactions for NR2F2 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NR2F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9343308
GO:0001701 in utero embryonic development IEA --
GO:0001764 neuron migration IEA --
GO:0001893 maternal placenta development IEA --
GO:0001937 negative regulation of endothelial cell proliferation IMP 19210544
genes like me logo Genes that share ontologies with NR2F2: view

Drugs & Compounds for NR2F2 Gene

(6) Drugs for NR2F2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for NR2F2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NR2F2: view

Transcripts for NR2F2 Gene

Unigene Clusters for NR2F2 Gene

Nuclear receptor subfamily 2, group F, member 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NR2F2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: - -
SP2:
SP3: -

Relevant External Links for NR2F2 Gene

GeneLoc Exon Structure for
NR2F2
ECgene alternative splicing isoforms for
NR2F2

Expression for NR2F2 Gene

mRNA expression in normal human tissues for NR2F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR2F2 Gene

This gene is overexpressed in Ovary (x4.7).

Protein differential expression in normal tissues from HIPED for NR2F2 Gene

This gene is overexpressed in Ovary (36.1), Bone (18.9), and Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NR2F2 Gene



Protein tissue co-expression partners for NR2F2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NR2F2 Gene:

NR2F2

SOURCE GeneReport for Unigene cluster for NR2F2 Gene:

Hs.347991

mRNA Expression by UniProt/SwissProt for NR2F2 Gene:

P24468-COT2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NR2F2: view

Primer Products

Orthologs for NR2F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2F2 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia NR2F2 34 35
  • 96.38 (n)
dog
(Canis familiaris)
Mammalia NR2F2 34 35
  • 96.22 (n)
mouse
(Mus musculus)
Mammalia Nr2f2 34 16 35
  • 95.33 (n)
rat
(Rattus norvegicus)
Mammalia Nr2f2 34
  • 95.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NR2F2 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2F2 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR2F2 34 35
  • 84.88 (n)
lizard
(Anolis carolinensis)
Reptilia NR2F2 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr2f2 34
  • 80.15 (n)
Str.11156 34
African clawed frog
(Xenopus laevis)
Amphibia nr2f2-prov 34
zebrafish
(Danio rerio)
Actinopterygii nr2f2 34 35
  • 77.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002544 34
  • 76.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta svp 36 34
  • 73.72 (n)
dsf 36
  • 41 (a)
Hr51 35
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-55 36
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9339 34
Species where no ortholog for NR2F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2F2 Gene

ENSEMBL:
Gene Tree for NR2F2 (if available)
TreeFam:
Gene Tree for NR2F2 (if available)

Paralogs for NR2F2 Gene

Paralogs for NR2F2 Gene

genes like me logo Genes that share paralogs with NR2F2: view

Variants for NR2F2 Gene

Sequence variations from dbSNP and Humsavar for NR2F2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs201527820 Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779] 96,337,611(+) ATATG(A/C/G/T)CAATT reference, missense
rs587777371 Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779], Pathogenic 96,337,399(+) AAAGT(A/C)TCAGT reference, missense
rs587777372 Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779], Pathogenic 96,334,247(+) CAACA(A/T)CATCA reference, missense
VAR_071767 Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779]
VAR_071769 Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779]

Structural Variations from Database of Genomic Variants (DGV) for NR2F2 Gene

Variant ID Type Subtype PubMed ID
dgv448n67 CNV gain 20364138
esv21861 CNV loss 19812545
nsv1126408 CNV deletion 24896259
nsv1141674 CNV deletion 24896259
nsv570580 CNV loss 21841781
nsv570581 CNV loss 21841781
nsv570582 CNV loss 21841781
nsv827449 CNV gain 20364138
nsv827450 CNV gain 20364138

Variation tolerance for NR2F2 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NR2F2 Gene

Human Gene Mutation Database (HGMD)
NR2F2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NR2F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2F2 Gene

Disorders for NR2F2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for NR2F2 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
congenital heart defects, multiple types, 4
  • chtd4
complete atrioventricular canal
  • cavc
ring chromosome 15
  • chromosome 15 ring
partial atrioventricular canal
  • partial atrioventricular septal defects
congenital diaphragmatic hernia
  • diaphragmatic hernia
- elite association - COSMIC cancer census association via MalaCards
Search NR2F2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

COT2_HUMAN
  • Congenital heart defects, multiple types, 4 (CHTD4) [MIM:615779]: A disorder characterized by congenital developmental abnormalities involving structures of the heart. Common defects include transposition of the great arteries, aortic stenosis, atrial septal defect, ventricular septal defect, pulmonic stenosis, and patent ductus arteriosus. Some patients also have cardiac arrhythmias, which may be due to the anatomic defect itself or to surgical interventions. {ECO:0000269 PubMed:24702954}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NR2F2

Genetic Association Database (GAD)
NR2F2
Human Genome Epidemiology (HuGE) Navigator
NR2F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR2F2
genes like me logo Genes that share disorders with NR2F2: view

No data available for Genatlas for NR2F2 Gene

Publications for NR2F2 Gene

  1. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. (PMID: 18798693) Kruse S.W. … Xu H.E. (PLoS Biol. 2008) 3 4 22 64
  2. Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. (PMID: 11544252) Liberati C. … Ronchi A. (J. Biol. Chem. 2001) 2 3 22 64
  3. The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. (PMID: 9343308) Chu K. … Zingg H.H. (J. Mol. Endocrinol. 1997) 3 4 22 64
  4. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PMID: 8530078) Qiu Y. … Tsai S.Y. (Genomics 1995) 2 3 22 64
  5. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. (PMID: 1899293) Ladias J.A.A. … Karathanasis S.K. (Science 1991) 3 4 22 64

Products for NR2F2 Gene

Sources for NR2F2 Gene

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