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NR2F2 Gene

protein-coding   GIFtS: 66
GCID: GC15P096869

Nuclear Receptor Subfamily 2, Group F, Member 2


(Previous symbols: ARP1, TFCOUP2)
  See NR2F2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Subfamily 2, Group F, Member 21 2     ADP-Ribosylation Factor Related Protein 12
ARP11 2 3 5     Apolipoprotein AI Regulatory Protein 12
TFCOUP21 2 3 5     Chicken Ovalbumin Upstream Promoter Transcription Factor 22
Apolipoprotein A-I Regulatory Protein 12 3     Chicken Ovalbumin Upstream Promoter-Transcription Factor I2
COUP Transcription Factor II2 3     COUP Transcription Factor 22
COUPTFB2     ARP-13
COUPTFII2     COUP-TF23
NF-E32     COUP-TF II3
NR2F12     Nuclear Receptor Subfamily 2 Group F Member 23
SVP402     

External Ids:    HGNC: 79761   Entrez Gene: 70262   Ensembl: ENSG000001855517   OMIM: 1077735   UniProtKB: P244683   

Export aliases for NR2F2 gene to outside databases

Previous GC identifers: GC15P093321 GC15P090625 GC15P094456 GC15P094603 GC15P094674 GC15P072999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NR2F2 Gene:
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is
a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate
splicing results in multiple transcript variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for NR2F2 Gene:
NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein-coding gene. Diseases associated with NR2F2 include ring chromosome 15, and partial atrioventricular canal. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot: COT2_HUMAN, P24468
Function: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and
all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the
apolipoprotein A-I gene transcription. Binds to DNA site A

Gene Wiki entry for NR2F2 (COUP-TFII) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR2F2 gene promoter:
         MyoD   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): NR2F2 promoter sequence
   Search Chromatin IP Primers for NR2F2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR2F2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26   Ensembl cytogenetic band:  15q26.2   HGNC cytogenetic band: 15q26

NR2F2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2F2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P096869:  view genomic region     (about GC identifiers)

Start:
96,869,157 bp from pter      End:
96,883,492 bp from pter
Size:
14,336 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COT2_HUMAN, P24468 (See protein sequence)
Recommended Name: COUP transcription factor 2  
Size: 414 amino acids; 45571 Da
Subunit: Interacts with SQSTM1 (By similarity). Binds DNA as a dimer; homodimer or heterodimer with NR2F6.
Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2 (By similarity)
1 PDB 3D structure from and Proteopedia for NR2F2:
3CJW (3D)    
Secondary accessions: B4DQJ2 B6ZGU1 Q03754 Q3KQR7
Alternative splicing: 3 isoforms:  P24468-1   P24468-2   P24468-3   

Explore the universe of human proteins at neXtProt for NR2F2: NX_P24468

Explore proteomics data for NR2F2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys301, Lys362
  • Modification sites at PhosphoSitePlus

  • See NR2F2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001138627.1  NP_001138628.1  NP_001138629.1  NP_066285.1  

    ENSEMBL proteins: 
     ENSP00000401674   ENSP00000377721   ENSP00000457112   ENSP00000389853   ENSP00000377726  
    Reactome Protein details: P24468

    NR2F2 Human Recombinant Protein Products:

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    Novus Biologicals NR2F2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NR2F2

     
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    antibodies-online proteins for NR2F2 (10 products) 

     
    antibodies-online peptides for NR2F2

    NR2F2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NR2F2
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    antibodies-online antibodies for NR2F2 (45 products) 

    NR2F2 Assay Products:

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    antibodies-online kits for NR2F2 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: COUP-TF2
    2F. COUP-TF-like receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR003068 COUP_TF

    Graphical View of Domain Structure for InterPro Entry P24468

    ProtoNet protein and cluster: P24468

    3 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003068 COUP transcription factor (2F nuclear receptor) family signature
    IPB013629 Zinc finger


    UniProtKB/Swiss-Prot: COT2_HUMAN, P24468
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with NR2F2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COT2_HUMAN, P24468
    Function: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and
    all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the
    apolipoprotein A-I gene transcription. Binds to DNA site A

         Genatlas biochemistry entry for NR2F2:
    nuclear receptor subfamily 2,group F,member 2,negative post transcriptional regulator of MYOD1 function,may be
    required for angiogenesis and heart developpment, steroid/thyroid hormone receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001972retinoic acid binding IDA18798693
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA9343308
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003714transcription corepressor activity TAS1899293
         
    Find genes that share ontologies with NR2F2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NR2F2:
     Upregulation of Wnt/beta-caten 

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nr2f2):
     cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  immune system  mortality/aging  muscle  nervous system 
     no phenotypic analysis  pigmentation  reproductive system  vision/eye 

    Find genes that share phenotypes with NR2F2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nr2f2tm1Tsa for NR2F2

       genOway: Develop your customized and physiologically relevant rodent model for NR2F2

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NR2F2 (see all 437):
    AATF,  ACOT4,  ACPT,  ADAMTSL5,  ADH5,  ADPRHL2,  ADRA1B,  AMICA1,  ANGPTL2,  ANKRD11

    miRNA
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    miRTarBase miRNAs that target NR2F2:
    hsa-mir-935 (MIRT036667), hsa-mir-101-3p (MIRT027270), hsa-mir-302a-3p (MIRT006555), hsa-mir-877-5p (MIRT037296)

    Block miRNA regulation of human, mouse, rat NR2F2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR2F2 (see all 93):
    hsa-miR-582-3p hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-3607-3p hsa-miR-300 hsa-miR-128 hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidNR2F2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NR2F2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): NR2F2 (NM_021005)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR2F2
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    Addgene plasmids for NR2F2 

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    eBioscience FlowRNA Probe Sets ( VA1-13173) for NR2F2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COT2_HUMAN, P24468: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19210544

    Find genes that share ontologies with NR2F2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NR2F2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptors0.67
    2L1CAM interactions
    Developmental Biology0.63
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    4Regulation of Telomerase
    Regulation of Telomerase
    5Oct4 in Mammalian ESC Pluripotency
    Oct4 in Mammalian ESC Pluripotency


    Find genes that share SuperPaths with NR2F2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for NR2F2
        Oct4 in Mammalian ESC Pluripotency

    3 BioSystems Pathways for NR2F2
        Nuclear Receptors
    FOXA1 transcription factor network
    Regulation of Telomerase

    1 Reactome Pathway for NR2F2
        Transcriptional regulation of white adipocyte differentiation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR2F2: 
              Terminal Differentiation Markers in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR2F2

    Selected Interacting proteins for NR2F2 (P244682, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 608)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR2F6P105882, 3MINT-7945693 I2D: score=4 
    HDAC1Q135472, 3MINT-7945693 I2D: score=3 
    HIPK3Q9H4222, 3MINT-61738 I2D: score=3 
    SQSTM1Q135012, 3MINT-7945693 I2D: score=2 
    NCOR2Q9Y6182, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA9343308
    GO:0001701in utero embryonic development ----
    GO:0001764neuron migration IEA--
    GO:0001893maternal placenta development IEA--
    GO:0001937negative regulation of endothelial cell proliferation IMP19210544

    Find genes that share ontologies with NR2F2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NR2F2 (COT2)

    9 Novoseek inferred chemical compound relationships for NR2F2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 60.8 28 1321332 (4), 8288643 (3), 20386594 (3), 8175747 (1) (see all 7)
    steroid 48.2 9 1899293 (2), 1312668 (1), 7947324 (1), 7567979 (1) (see all 7)
    estrogen 32.8 10 10221773 (2), 10772965 (1), 17590085 (1), 19154418 (1) (see all 6)
    cholesterol 22.5 2 1899293 (1), 10627496 (1)
    progesterone 17.4 3 17590085 (3)
    chloramphenicol 9.06 3 8530390 (1), 9343308 (1)
    lipid 0 2 1899293 (1), 18765665 (1)
    glucose 0 8 19862665 (6), 18765665 (2)
    tyrosine 0 1 16815388 (1)



    Find genes that share compounds with NR2F2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NR2F2 gene (4 alternative transcripts): 
    NM_001145155.1  NM_001145156.1  NM_001145157.1  NM_021005.3  

    Unigene Clusters for NR2F2:

    Nuclear receptor subfamily 2, group F, member 2
    Hs.347991  [show with all ESTs], Hs.519445  [show with all ESTs]
    Unigene Representative Sequences: NM_021005, NM_005654
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421109 ENST00000394166(uc010uri.2) ENST00000559679 ENST00000453270
    ENST00000394171(uc002btp.3 uc010urj.2 uc010urk.2)
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    hsa-miR-582-3p hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-3607-3p hsa-miR-300 hsa-miR-128 hsa-miR-30d
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    Inhib. RNA
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    Addgene plasmids for NR2F2 
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    Additional mRNA sequence: 

    AF087978.1 BC004154.2 BC017493.1 HQ709180.1 HQ709181.1 HQ709182.1 HQ709183.1 X16155.1 

    Selected DOTS entries (see all 27):

    DT.86854402  DT.101981327  DT.102835104  DT.100827459  DT.121032729  DT.448656  DT.40247694  DT.209110 
    DT.121032835  DT.95323546  DT.100659900  DT.100827457  DT.102835101  DT.75109795  DT.100028492  DT.40203455 
    DT.75133849  DT.99960896  DT.120887286  DT.120887299  DT.40118356  DT.75160199  DT.92430669  DT.95078565 

    Selected AceView cDNA sequences (see all 292):

    AI318417 BX111982 CD516542 BC042897 NM_021005 BM789555 CA449328 AI420144 
    BI496206 AI359911 BM718510 AA195460 AA378155 AI436210 AA418510 AW628809 
    BM982769 AI373394 AW571531 AI359059 AI521030 BF196584 AA393875 BC034585 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NR2F2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
    SP1:              -     -                     
    SP2:                                          
    SP3:                    -                     


    ECgene alternative splicing isoforms for NR2F2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NR2F2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATTTTAA
    NR2F2 Expression
    About this image


    NR2F2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiomyocytes Left Atrium
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             Venous Endothelial Cells Cardinal Veins
             Human umbilical vein endothelial cells (HUVEC)
     
     Kidney (Urinary System)    fully expand to see all 11 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             AII Amacrine Cells Inner Nuclear Layer
             Optic cup
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Telencephalon
    NR2F2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR2F2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.347991 Hs.519445

    UniProtKB/Swiss-Prot: COT2_HUMAN, P24468
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR2F2: 
              Terminal Differentiation Markers in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for NR2F2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NR2F2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr2f21 , 5 nuclear receptor subfamily 2, group F, member 21, 5 95.33(n)1
    100(a)1
      7 (38.66 cM)5
    118191  NM_009697.31  NP_033827.21 
     703519465 
    chicken
    (Gallus gallus)
    Aves NR2F21 nuclear receptor subfamily 2, group F, member 2 84.88(n)
    94.63(a)
      386585  NM_204421.1  NP_989752.1 
    lizard
    (Anolis carolinensis)
    Reptilia NR2F26
    nuclear receptor subfamily 2, group F, member 2
    74(a)
    1 ↔ 1
    GL343363.1(10058-25729)
    African clawed frog
    (Xenopus laevis)
    Amphibia nr2f2-prov2 nuclear receptor subfamily 2, group F, member 2 81.36(n)    BC044975.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr2f22 nuclear receptor subfamily 2, group F, member 2 80.79(n)   30424  NM_131183.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta svp1 , 3 cardioblast determination receptor3
    seven up1
    87(a)
    (best of 2)3
    73.72(n)1
    84.34(a)1
      87B53
    414911  NM_079601.31  NP_524325.11 


    ENSEMBL Gene Tree for NR2F2 (if available)
    TreeFam Gene Tree for NR2F2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NR2F2 gene
    RXRA2  RXRG2  NR2F12  HNF4G2  NR2C12  NR2F62  NR2E12  HNF4A2  
    RXRB2  NR2C22  
    Selected SIMAP similar genes for NR2F2 using alignment to 3 protein entries:     COT2_HUMAN (see all proteins) (see all similar genes):
    NR2F1    NR2F6    RXRA    NR2B1    HNF4A    HNF4G
    NR2A2    NR2A3    RXRG    NR2A1    NR2B3    RXRB
    NR2E1    ESRRB    NR2E3    ERRgamma    ESRRG    NR2B2

    Find genes that share paralogs with NR2F2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NR2F2 (see all 218)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447936361,2
    --73004421(+) ATGACA/GGCGAG 1 -- us2k10--------
    rs1418338601,2
    --76595777(+) TTGAGA/GTAGAA 2 -- us2k1 int10--------
    rs1884597451,2
    C--76595801(+) TGGTTA/CTTGTG 2 -- us2k1 int10--------
    rs766957291,2
    C,F--76595842(+) CAGAAT/CCTCTG 2 -- us2k1 int13Minor allele frequency- C:0.18WA CSA 121
    rs1506526931,2
    --76595960(+) GTGTAC/TATTGA 2 -- us2k1 int10--------
    rs1387807331,2
    --76595983(+) TGATAC/TATGTG 2 -- us2k1 int10--------
    rs601490111,2
    C,F--76596016(+) GTGTGC/AACAGG 2 -- us2k1 int12Minor allele frequency- A:0.21WA 120
    rs1923481201,2
    --76596131(+) ACCAGC/GGAGAG 2 -- us2k1 int10--------
    rs1175393941,2
    C,F--76596266(+) ATGTTA/GACCCT 2 -- us2k1 int11Minor allele frequency- G:0.01EA 120
    rs38095571,2
    C,F,H--76596323(+) TATATA/GTCATA 2 -- us2k1 int122Minor allele frequency- G:0.30NS EA NA WA CSA 2350

    HapMap Linkage Disequilibrium report for NR2F2 (96869157 - 96883492 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NR2F2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21861CNV Loss19812545
    nsv904532CNV Loss21882294
    dgv448n67CNV Gain20364138
    nsv827450CNV Gain20364138
    nsv827449CNV Gain20364138

    Human Gene Mutation Database (HGMD): NR2F2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR2F2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107773    OMIM disorders: --

    7 diseases for NR2F2:    
    About MalaCards
    ring chromosome 15    partial atrioventricular canal    complete atrioventricular canal    congenital heart defects, multiple types, 4
    glucocorticoid resistance    congenital diaphragmatic hernia    endometriosis

    1 disease from the University of Copenhagen DISEASES database for NR2F2:
    Congenital diaphragmatic hernia

    Find genes that share disorders with NR2F2           About GenesLikeMe

    6 Novoseek inferred disease relationships for NR2F2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometriosis 47.8 2 16815388 (2)
    carcinoma embryonal 43.5 1 7947324 (1)
    breast cancer 3.82 13 19154418 (3), 12525252 (2), 17047084 (2), 10772965 (2) (see all 5)
    ovarian cancer 0 1 15010821 (1)
    adenoma 0 7 10946877 (2), 12943735 (1)
    tumors 0 12 10946877 (2), 15824151 (2), 20364082 (1), 7567979 (1) (see all 6)

    Genetic Association Database (GAD): NR2F2
    Human Genome Epidemiology (HuGE) Navigator: NR2F2 (9 documents)

    Export disorders for NR2F2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NR2F2 gene, integrated from 10 sources (see all 142):
    (articles sorted by number of sources associating them with NR2F2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cooperation and competition between the binding of COUP-TFII and NF-Y on human epsilon- and gamma-globin gene promoters. (PubMed id 11544252)1, 3, 9 Liberati C....Ronchi A. (J. Biol. Chem. 2001)
    2. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. (PubMed id 1899293)1, 2, 9 Ladias J.A.A. and Karathanasis S.K. (Science 1991)
    3. Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. (PubMed id 18798693)1, 2, 9 Kruse S.W.... Xu H.E. (PLoS Biol. 2008)
    4. The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter. (PubMed id 9343308)1, 2, 9 Chu K. and Zingg H.H. (J. Mol. Endocrinol. 1997)
    5. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PubMed id 8530078)1, 3, 9 Qiu Y....Tsai S.Y. (Genomics 1995)
    6. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. (PubMed id 10318855)1, 2 Avram D.... Leid M. (J. Biol. Chem. 1999)
    10. The COUP-TFs compose a family of functionally related transcription factors. (PubMed id 1820218)1, 2 Wang L.H.... Tsai M.J. (Gene Expr. 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7026 HGNC: 7976 AceView: NR2F2 Ensembl:ENSG00000185551 euGenes: HUgn7026
    ECgene: NR2F2 H-InvDB: NR2F2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NR2F2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NR2F2 gene:
    Search GeneIP for patents involving NR2F2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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