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NR2F1 Gene

protein-coding   GIFtS: 61
GCID: GC05P092920

Nuclear Receptor Subfamily 2, Group F, Member 1


(Previous symbols: ERBAL3, TFCOUP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Subfamily 2, Group F, Member 11 2     COUP-TFI2
ERBAL31 2 3 5     NR2F22
TFCOUP11 2 3 5     SVP442
EAR32 3 5     TCFCOUP12
COUP-TF12 3     Chicken Ovalbumin Upstream Promoter-Transcription Factor I2
EAR-32 3     COUP Transcription Factor 12
COUP Transcription Factor I2 3     Transcription Factor COUP 1 (Chicken Ovalbumin Upstream Promoter 1,
V-Erb-A Homolog-Like 3)2
COUP-TF I2 3     Nuclear Receptor Subfamily 2 Group F Member 13
V-ErbA-Related Protein 32 3     BBOAS5

External Ids:    HGNC: 79751   Entrez Gene: 70252   Ensembl: ENSG000001757457   OMIM: 1328905   UniProtKB: P105893   

Export aliases for NR2F1 gene to outside databases

Previous GC identifers: GC05P091970 GC05P093388 GC05P092947 GC05P092993 GC05P092944 GC05P088092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NR2F1 Gene:
NR2F1 (nuclear receptor subfamily 2, group F, member 1) is a protein-coding gene. Diseases associated with NR2F1 include middle ear carcinoma, and ovarian epithelial cancer. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot: COT1_HUMAN, P10589
Function: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in
conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats
and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG

Gene Wiki entry for NR2F1 (COUP-TFI) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NR2F1 gene promoter:
         AP-1   ATF-2   HNF-4alpha2   HNF-4alpha1   CREB   PPAR-gamma1   deltaCREB   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR2F1 promoter sequence
   Search Chromatin IP Primers for NR2F1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q14

NR2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2F1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P092920:  view genomic region     (about GC identifiers)

Start:
92,919,043 bp from pter      End:
92,930,321 bp from pter
Size:
11,279 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COT1_HUMAN, P10589 (See protein sequence)
Recommended Name: COUP transcription factor 1  
Size: 423 amino acids; 46156 Da
Subunit: Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2
1 PDB 3D structure from and Proteopedia for NR2F1:
2EBL (3D)    

Explore the universe of human proteins at neXtProt for NR2F1: NX_P10589

Explore proteomics data for NR2F1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys308, Lys369
  • Modification sites at PhosphoSitePlus

  • See NR2F1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005645.1  
    ENSEMBL proteins: 
     ENSP00000325819  
    Reactome Protein details: P10589

    NR2F1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NR2F1

    NR2F1 Antibody Products:

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    NR2F1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NR2F1
    Cloud-Clone Corp. CLIAs for NR2F1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: COUP-TF1
    2F. COUP-TF-like receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR003068 COUP_TF

    Graphical View of Domain Structure for InterPro Entry P10589

    ProtoNet protein and cluster: P10589

    3 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB003068 COUP transcription factor (2F nuclear receptor) family signature
    IPB013629 Zinc finger


    UniProtKB/Swiss-Prot: COT1_HUMAN, P10589
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    NR2F1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COT1_HUMAN, P10589
    Function: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in
    conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats
    and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG
    Induction: Inhibited by gonadotropin in granulosa cells

         Genatlas biochemistry entry for NR2F1:
    nuclear receptor subfamily 2,group F,member 1,steroid/thyroid hormone receptor

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10644740
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003713transcription coactivator activity TAS2739739
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI11043578
         
    NR2F1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NR2F1:
     Decreased viability  Upregulation of Wnt/beta-caten 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Nr2f1):
     behavior/neurological  cellular  hearing/vestibular/ear  mortality/aging  nervous system 
     no phenotypic analysis  normal  pigmentation  vision/eye 

    NR2F1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NR2F1: Nr2f1tm1Mist Nr2f1tm1Mjts

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR2F1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NR2F1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR2F1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR2F1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for NR2F1 (see all 348):
    A4GALT,  ABCA3,  ABCC3,  ABCC9,  ACAP1,  ACMSD,  ACP2,  ACSF2,  ADAMTSL1,  ADCK2

    miRNA
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    miRTarBase miRNAs that target NR2F1:
    hsa-mir-181b-5p (MIRT047264), hsa-mir-149-5p (MIRT045568)

    Block miRNA regulation of human, mouse, rat NR2F1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NR2F1:
    hsa-miR-4309 hsa-miR-486-3p hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmidNR2F1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NR2F1
    Predesigned siRNA for gene silencing in human, mouse, rat NR2F1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NR2F1

    Clone
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    OriGene clones in human, mouse for NR2F1 (see all 7)
    OriGene ORF clones in mouse, rat for NR2F1
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    GenScript: all cDNA clones in your preferred vector: NR2F1 (NM_005654)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR2F1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2F1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NR2F1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NR2F1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2F1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COT1_HUMAN, P10589: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10644740
    GO:0005654nucleoplasm TAS--

    NR2F1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NR2F1 About    
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Oct4 in Mammalian ESC Pluripotency
    Oct4 in Mammalian ESC Pluripotency
    4AHR Pathway (Qiagen)
    AHR Pathway
    5Adipogenesis
    Adipogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NR2F1
        AHR Pathway
    Oct4 in Mammalian ESC Pluripotency

    2 BioSystems Pathways for NR2F1
        Adipogenesis
    Nuclear Receptors

    1 Reactome Pathway for NR2F1
        Nuclear Receptor transcription pathway



    NR2F1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR2F1: 
              Multiple Sclerosis in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NR2F1 (P105892, 3 ENSP000003258194) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2BQ004032, 3, ENSP000003595314MINT-69585 MINT-69587 MINT-69593 I2D: score=4 STRING: ENSP00000359531
    PFDN1O609252, 3, ENSP000002618134MINT-8265941 I2D: score=2 STRING: ENSP00000261813
    AHRP358693, ENSP000002420574I2D: score=3 STRING: ENSP00000242057
    ISL1P613713, ENSP000002306584I2D: score=2 STRING: ENSP00000230658
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10644740
    GO:0001764neuron migration IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007165signal transduction TAS2739739

    NR2F1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NR2F1 (COT1)

    7 Novoseek inferred chemical compound relationships for NR2F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 62.3 10 19903244 (3), 10668629 (2), 10207062 (1), 8119938 (1) (see all 6)
    4-hydroxytamoxifen 57.5 1 17047084 (1)
    estrogen 49.6 9 17674191 (2), 17549341 (1), 20382891 (1), 10619353 (1) (see all 5)
    steroid 33.8 6 10913260 (2), 2263450 (1), 7947324 (1), 7567979 (1) (see all 5)
    estradiol 27.8 3 17047084 (1), 10620335 (1), 17674191 (1)
    oligonucleotide 0 1 10668629 (1)
    progesterone 0 1 17549341 (1)



    NR2F1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NR2F1 gene: 
    NM_005654.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327111(uc003kkj.3 uc021ybj.1 uc021ybk.1) ENST00000512697
    ENST00000502982 ENST00000506162
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate NR2F1:
    hsa-miR-4309 hsa-miR-486-3p hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmidNR2F1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NR2F1
      QuantiFast Probe-based Assays in human, mouse, rat NR2F1

    Selected AceView cDNA sequences (see all 163):

    AA599756 CB267135 CA337800 AA397965 BU509540 BI491949 H88844 BQ716742 
    BU167729 AW673019 AF087978 BQ938177 AL134403 AL524986 AW302624 BM845897 
    BI491051 BF439956 AI741822 AI089845 BC004154 R62296 BM719119 AA435903 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NR2F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NR2F1 Expression
    About this image


    NR2F1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
             Telencephalon
             Floor plate-like cells
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Anterior Entopeduncular Progenitor Cells Anterior Entopeduncular Area
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             S-shaped Body
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     NULL (Uncategorized)
             CD2314-induced embryoid bodies
    NR2F1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR2F1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR2F1: 
              Multiple Sclerosis in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NR2F1
    OriGene qSTAR qPCR primer pairs in human, mouse for NR2F1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NR2F1
    QuantiTect SYBR Green Assays in human, mouse, rat NR2F1
    QuantiFast Probe-based Assays in human, mouse, rat NR2F1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2F1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NR2F1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr2f11 , 5 nuclear receptor subfamily 2, group F, member 11, 5 94.44(n)1
    98.81(a)1
      13 (41.38 cM)5
    138651  NM_010151.21  NP_034281.21 
     781889735 
    chicken
    (Gallus gallus)
    Aves LOC1008595191 nuclear receptor subfamily 2 group F member 1-A-like 90.83(n)
    94.98(a)
      100859519  XM_004949402.1  XP_004949459.1 
    lizard
    (Anolis carolinensis)
    Reptilia NR2F16
    nuclear receptor subfamily 2, group F, member 1
    97(a)
    1 ↔ 1
    2(24823130-24838409)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.5282 Xenopus laevis COUP transcription factor 1 mRNA, complete more 84.13(n)    AF157558.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr2f12 nuclear receptor subfamily 2, group F, member 1 82.03(n)   30418  NM_131180.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta svp3 cardioblast determination receptor 87(a)
    (best of 2)
      87B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-551 , 3 nuclear hormone receptor3
    unc-551
    34(a)3
    46.39(n)1
    42.63(a)1
      I(7907104-7911844)3
    1920821  NM_001129010.21  NP_001122482.21 


    ENSEMBL Gene Tree for NR2F1 (if available)
    TreeFam Gene Tree for NR2F1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NR2F1 gene
    RXRA2  RXRG2  NR2F22  HNF4G2  NR2C12  NR2F62  NR2E12  HNF4A2  
    RXRB2  NR2C22  
    Selected SIMAP similar genes for NR2F1 using alignment to 5 protein entries:     COT1_HUMAN (see all proteins) (see all similar genes):
    NR2F2    NR6A1    THRB    NR2F6    NR5A1    NR3C2
    VDR    NR2C2    HNF4G    HNF4alpha    ESR1    PPARG
    RORA    RXRB    RXRA    NR2A2    RXRG    NR2B3

    NR2F1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NR2F1 (see all 165)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1462380251,2
    C--92917582(+) CTCTC-/CTCTCTC 1 -- us2k10--------
    rs769813681,2
    C,F--92919142(+) TGTTTT/CCCCCT 1 -- ut511Minor allele frequency- C:0.06NA 120
    rs1506762331,2
    --92919822(+) TCACCA/GCGCTC 1 -- ut510--------
    rs1998448821,2
    C--92920966(+) GGCCAG/CAGCCA 2 /H /Q mis11Minor allele frequency- C:0.01EU 227
    rs4007931,2
    H--92921319(-) GAGAAG/AGAAAG 1 -- int1 trp32Minor allele frequency- A:0.00MN NS 304
    rs1727541,2
    C--92921396(-) GCGCAA/C/GGCCGG 1 -- int11NA 2
    rs1912239731,2
    --92921745(+) GAAAAA/CGAGGA 1 -- int10--------
    rs1149207141,2
    C,F--92921819(+) GTTCCC/TTCTCT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1432842341,2
    C--92921845(+) GGCCG-/CCTCCTCC 1 -- int10--------
    rs1817801601,2
    --92922041(+) ATTTGA/GCCGTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NR2F1 (92919043 - 92930321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NR2F1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4918CNV Loss18451855
    nsv882383CNV Loss21882294
    nsv830404CNV Loss17160897
    esv23147CNV Loss19812545
    dgv954n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): NR2F1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR2F1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 132890   
    OMIM disorders: 615722  
    Selected diseases for NR2F1 (see all 22):    
    About MalaCards
    middle ear carcinoma    ovarian epithelial cancer    bladder transitional cell carcinoma    transitional cell carcinoma
    cushing's syndrome    conjunctivitis    hepatitis b    esophageal squamous cell carcinoma
    adenoma    retinoblastoma    neuroblastoma    multiple sclerosis
    esophagitis    hepatitis    squamous cell carcinoma    hiv-1
    breast cancer    adenocarcinoma    thyroiditis    endotheliitis


    NR2F1 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for NR2F1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    salivary gland adenocarcinoma 78.3 2 10668629 (1), 9599664 (1)
    adenoma adrenocortical 67.7 4 9851803 (4)
    carcinoma embryonal 35.6 1 7947324 (1)
    cushing syndrome 30.1 1 11592817 (1)
    breast cancer 28.7 12 17674191 (3), 17047084 (2), 10772965 (1), 9395481 (1) (see all 7)
    adenoma 23.5 15 12943735 (2), 11592817 (1), 19526345 (1), 9851803 (1)
    tumors 3.8 14 19526345 (5), 15824151 (2), 7567979 (1), 11973645 (1) (see all 8)
    hepatitis b 0 2 12551987 (2)
    cancer 0 4 11850205 (1), 17549341 (1), 15955695 (1), 12650705 (1)

    Genetic Association Database (GAD): NR2F1
    Human Genome Epidemiology (HuGE) Navigator: NR2F1 (3 documents)

    Export disorders for NR2F1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NR2F1 gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with NR2F1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PubMed id 8530078)1, 3, 9 Qiu Y....Tsai S.Y. (Genomics 1995)
    2. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. (PubMed id 10207062)1, 2, 9 Dressel U.... Baniahmad A. (Mol. Cell. Biol. 1999)
    3. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PubMed id 19578876)1, 4 Johnson M.P....Moses E.K. (Hum. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PubMed id 10644740)1, 2 Zhang Y. and Dufau M.L. (J. Biol. Chem. 2000)
    6. COUP transcription factor is a member of the steroid receptor superfamily. (PubMed id 2739739)1, 2 Wang L.-H....O'Malley B.W. (Nature 1989)
    7. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PubMed id 2905047)1, 2 Miyajima N.... Yamamoto T. (Nucleic Acids Res. 1988)
    8. COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells. (PubMed id 17674191)1, 9 Le Dily F....Pakdel F. (Breast Cancer Res. Treat. 2008)
    9. Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB. (PubMed id 12972613)1, 9 Zhang Y. and Dufau M.L. (Mol. Cell. Biol. 2003)
    10. Immunohistochemistry of COUP-TFI: an adjuvant diagnostic tool for the identification of corticotroph microadenomas. (PubMed id 19526345)1, 9 Bush Z.M....Vance M.L. (Pituitary 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7025 HGNC: 7975 AceView: NR2F1 Ensembl:ENSG00000175745 euGenes: HUgn7025
    ECgene: NR2F1 H-InvDB: NR2F1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NR2F1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NR2F1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NR2F1 gene:
    Search GeneIP for patents involving NR2F1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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