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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR2F1 Gene

protein-coding   GIFtS: 59
GCID: GC05P092920

nuclear receptor subfamily 2, group F, member 1


(Previous symbols: ERBAL3, TFCOUP1)
 Explore 22 diseases affiliated with
NR2F1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NR2F1    

Aliases
for NR2F1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Receptor Subfamily 2, Group F, Member 11 2     COUP Transcription Factor I2 3
ERBAL31 2 3 5     COUP-TF I2 3
TFCOUP11 2 3 5     V-ErbA-Related Protein 32 3
EAR-31 2 3     NR2F22
EAR32 3 5     Chicken Ovalbumin Upstream Promoter-Transcription Factor I2
COUP-TFI1 2     COUP Transcription Factor 12
SVP441 2     Transcription Factor COUP 1 (Chicken Ovalbumin Upstream Promoter 1, V-Erb-A
Homolog-Like 3)2
TCFCOUP11 2     Nuclear Receptor Subfamily 2 Group F Member 13
COUP-TF12 3     

External Ids:    HGNC: 79751   Entrez Gene: 70252   Ensembl: ENSG000001757457   OMIM: 1328905   UniProtKB: P105893   

Export aliases for NR2F1 gene to outside databases

Previous GC identifers: GC05P091970 GC05P093388 GC05P092947 GC05P092993 GC05P092944 GC05P088092


Summaries
for NR2F1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: COT1_HUMAN, P10589
Function: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in
conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and
palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG

Gene Wiki entry for NR2F1 (COUP-TFI)


Genomic Views
for NR2F1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR2F1 gene promoter:
         AP-1   ATF-2   HNF-4alpha2   HNF-4alpha1   CREB   PPAR-gamma1   deltaCREB   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR2F1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR2F1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2F1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q14

NR2F1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2F1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P092920:  view genomic region     (about GC identifiers)

Start:
 92,919,043 bp from pter      End:
 92,930,321 bp from pter
Size:
 11,279 bases      Orientation:
 plus strand

Proteins
for NR2F1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: COT1_HUMAN, P10589 (See protein sequence)
Recommended Name: COUP transcription factor 1  
Size: 423 amino acids; 46156 Da
Subunit: Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for NR2F1:
2EBL (3D)    

Explore the universe of human proteins at neXtProt for NR2F1: NX_P10589

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P10589

    • NR2F1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005645.1  
    ENSEMBL proteins: 
     ENSP00000325819  
    Reactome Protein details: P10589
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NR2F1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10644740
    GO:0005654nucleoplasm TAS--


    NR2F1 for ontologies           About GeneDecksing



    NR2F1 Antibody Products: 
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    Uscn ELISAs and CLIAs for NR2F1

    Protein Domains /
    Families
    for NR2F1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NR2F1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR003068 COUP_TF

    Graphical View of Domain Structure for InterPro Entry P10589

    ProtoNet protein and cluster: P10589

    3 Blocks protein families:
    IPB001723 Steroid hormone receptor signature
    IPB003068 COUP transcription factor (2F nuclear receptor) family signature
    IPB013629 Zinc finger


    UniProtKB/Swiss-Prot: COT1_HUMAN, P10589
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Function
    for NR2F1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: COT1_HUMAN, P10589
    Function: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in
    conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and
    palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG
    Induction: Inhibited by gonadotropin in granulosa cells

         Genatlas biochemistry entry for NR2F1:
    nuclear receptor subfamily 2,group F,member 1,steroid/thyroid hormone receptor

    10/369 SABiosciences Target genes for NR2F1 (see all 369):
    A4GALT ABCA3 ABCC3 ABCC9 ACAP1 ACMSD ACP2 ACSF2 ADAMTSL1 ADCK2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NR2F1
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NR2F1:
    hsa-miR-4309 hsa-miR-486-3p hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmid: NR2F1 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: NR2F1
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NR2F1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for NR2F1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10644740
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003713transcription coactivator activity TAS2739739
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI11043578


    NR2F1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NR2F1:
     Decreased viability  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for NR2F1: Nr2f1tm1Mist Nr2f1tm1Mjts
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Nr2f1):
     behavior/neurological  cellular  hearing/vestibular/ear  mortality/aging  nervous system 
     no phenotypic analysis  pigmentation  vision/eye 

    NR2F1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NR2F1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Nuclear Receptor transcription pathway
    		Nuclear Receptor transcription pathway1.00
    		Nuclear Receptors0.68
    2Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    3Oct4 in Mammalian ESC Pluripotency
    		Oct4 in Mammalian ESC Pluripotency1.00
    4Adipogenesis
    		Adipogenesis1.00
    5AHR Pathway
    		AHR Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NR2F1
        AHR Pathway
    Oct4 in Mammalian ESC Pluripotency

    2 BioSystems Pathways for NR2F1 
        Nuclear Receptors
    Adipogenesis

    3        Reactome Pathways for NR2F1
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression



    NR2F1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR2F1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for NR2F1 (P105892, 3 ENSP000003258194) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2BQ004032, 3, ENSP000003595314MINT-69585 MINT-69587 MINT-69593 I2D: score=4 STRING: ENSP00000359531
    PFDN1O609252, 3, ENSP000002618134MINT-8265941 I2D: score=2 STRING: ENSP00000261813
    AHRP358693, ENSP000002420574I2D: score=3 STRING: ENSP00000242057
    ISL1P613713, ENSP000002306584I2D: score=2 STRING: ENSP00000230658
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA10644740
    GO:0001764neuron migration IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007165signal transduction TAS2739739


    NR2F1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NR2F1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NR2F1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NR2F1
    7 Novoseek chemical compound relationships for NR2F1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 62.3 10 19903244 (3), 10668629 (2), 10207062 (1), 8119938 (1) (see all 6)
    4-hydroxytamoxifen 57.5 1 17047084 (1)
    estrogen 49.6 9 17674191 (2), 17549341 (1), 20382891 (1), 10619353 (1) (see all 5)
    steroid 33.8 6 10913260 (2), 2263450 (1), 7947324 (1), 7567979 (1) (see all 5)
    estradiol 27.8 3 17047084 (1), 10620335 (1), 17674191 (1)
    oligonucleotide 0 1 10668629 (1)
    progesterone 0 1 17549341 (1)

    Search CenterWatch for drugs/clinical trials and news about NR2F1 / COT1 

    Transcripts
    for NR2F1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NR2F1 gene: 
    NM_005654.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327111(uc003kkj.3 uc021ybj.1 uc021ybk.1) ENST00000512697
    ENST00000502982 ENST00000506162

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate NR2F1:
    hsa-miR-4309 hsa-miR-486-3p hsa-miR-1289
    SwitchGear 3'UTR luciferase reporter plasmid: NR2F1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR2F1 (see all 7)
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    Clone
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    Primer
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    24/163 AceView cDNA sequences (see all 163):

    AI089845 BI491051 AA349010 BG057986 AA435903 BM848059 BF725396 AF087978 
    AL524986 AA599756 BU507999 BQ716742 H88844 BU167729 BQ938177 BM923802 
    H88956 BM845897 BQ022034 AL539021 AL134403 BU509540 NM_005654 CA337800 

    GeneLoc Exon Structure


    Expression
    for NR2F1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR2F1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NR2F1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerCone Precursor CellsPhotoreceptors, Retina
    EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor CellsRetinal Pigmented Epithelium
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Embryoid bodies (Generation of adipoc...)
    N2/LSB induced-cells (Generation of midbra...)
    Posterior foregut-like cells (A scalable, suspensi...)

    See NR2F1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR2F1
        SABiosciences Expression via Pathway-Focused PCR Arrays including NR2F1: 
              Multiple Sclerosis in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for NR2F1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NR2F1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008595191 nuclear receptor subfamily 2 group F member 1-A-like 92.55(n)
    96.87(a)    		   100859519  XM_003643066.1  XP_003643114.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NR2F16
    		 --
    		 97(a)
    		 1 ↔ 1
    		 2(24823130-24838409)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.5282 Xenopus laevis COUP transcription factor 1 mRNA, complete more 84.13(n)    AF157558.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nr2f12 nuclear receptor subfamily 2, group F, member 1 82.03(n)   30418  NM_131180.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta svp3 cardioblast determination receptor 87(a)
    (best of 2)    		   87B5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-551 , 3 nuclear hormone receptor3
    Protein UNC-551    		 34(a)3
    46.05(n)1
    41.04(a)1    		   I(7907104-7911844)3
    1920821  NM_001129010.11  NP_001122482.11 


    ENSEMBL Gene Tree for NR2F1 (if available)
    TreeFam Gene Tree for NR2F1 (if available) 

    Paralogs
    for NR2F1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR2F1 gene
    ESRRA2  RXRG2  PGR2  ESR22  ESRRB2  HNF4G2  NR2F62  NR2E12  
    ESRRG2  NR3C22  RXRA2  NR3C12  NR2F22  AR2  ESR12  NR2C12  
    HNF4A2  NR2C22  RXRB2  
    18/39 SIMAP similar genes for NR2F1 using alignment to 5 protein entries:     COT1_HUMAN (see all proteins) (see all similar genes):
    NR2F2    NR6A1    NR2F6    PPARA    THRB    NR5A1
    NR3C2    VDR    NR2C2    HNF4G    HNF4alpha    ESR1
    PPARG    RORA    RXRA    NR2A2    RXRG    NR2B3

    NR2F1 for paralogs           About GeneDecksing



    Genomic Variants
    for NR2F1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/166 NCBI SNPs in NR2F1 are shown (see all 166)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1835497811,2
    		--92917046(+) TAGGGA/GAGCGA 3 -- us2k10--------
    rs1878926031,2
    		--92917101(+) ACTAAC/TAGAAG 3 -- us2k10--------
    rs1924513971,2
    		--92917334(+) CCTCCA/CGCGAC 3 -- us2k10--------
    rs1407536191,2
    		--92917373(+) GTCTC-/GGTCTCT 3 -- us2k10--------
    rs1998098091,2
    		--92917544(+) TCTCC-/TC    
       TCTCT    CTCTC     		3 -- us2k10--------
    rs2012227131,2
    		--92917565(+) TCTCT-/CCTCTC 3 -- us2k10--------
    rs1462380251,2
    		C,--92917582(+) CTCTC-/CTCTCTC 3 -- us2k10--------
    rs2012890881,2
    		--92917668(+) CTGGG-/TCTCTC
    TCTCTCTCC    TCTCT     		3 -- us2k10--------
    rs1440732591,2
    		C,--92917710(+) TCTCT-/TCTCTCT 3 -- us2k10--------
    rs1997871581,2
    		--92917727(+) TCTCT-/CAATATC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for NR2F1 (92919043 - 92930321 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NR2F1
         1 CNV: 69162
    Human Gene Mutation Database (HGMD): NR2F1

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    Disorders / Diseases
    for NR2F1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NR2F1 for disorders           About GeneDecksing

    OMIM gene information: 132890    OMIM disorders: --

    20/22 diseases for NR2F1 (see all 22):    About MalaCards
    middle ear carcinoma    bladder transitional cell carcinoma    transitional cell carcinoma    cushing's syndrome
    esophageal squamous cell carcinoma    squamous cell carcinoma    hepatitis b    adrenocortical tumor
    embryonal carcinoma    adenoma    carcinoma    breast cancer
    conjunctivitis    esophagitis    retinoblastoma    hepatitis
    breast carcinoma    adenocarcinoma    neuroblastoma    immunodeficiency

    9 Novoseek disease relationships for NR2F1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    salivary gland adenocarcinoma 78.3 2 10668629 (1), 9599664 (1)
    adenoma adrenocortical 67.7 4 9851803 (4)
    carcinoma embryonal 35.6 1 7947324 (1)
    cushing syndrome 30.1 1 11592817 (1)
    breast cancer 28.7 12 17674191 (3), 17047084 (2), 10772965 (1), 9395481 (1) (see all 7)
    adenoma 23.5 15 12943735 (2), 11592817 (1), 19526345 (1), 9851803 (1)
    tumors 3.8 14 19526345 (5), 15824151 (2), 7567979 (1), 11973645 (1) (see all 8)
    hepatitis b 0 2 12551987 (2)
    cancer 0 4 11850205 (1), 17549341 (1), 15955695 (1), 12650705 (1)

    Human Genome Epidemiology (HuGE) Navigator: NR2F1 (3 documents)

    Export disorders for NR2F1 gene to outside databases

    Publications
    for NR2F1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR2F1 gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with NR2F1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes. (PubMed id 8530078)1, 3, 9 Qiu Y....Tsai S.Y. (1995)
    2. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. (PubMed id 10207062)1, 2, 9 Dressel U.... Baniahmad A. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PubMed id 10644740)1, 2 Zhang Y. and Dufau M.L. (2000)
    5. COUP transcription factor is a member of the steroid receptor superfamily. (PubMed id 2739739)1, 2 Wang L.-H....O'Malley B.W. (1989)
    6. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. (PubMed id 2905047)1, 2 Miyajima N.... Yamamoto T. (1988)
    7. COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells. (PubMed id 17674191)1, 9 Le Dily F....Pakdel F. (2008)
    8. Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB. (PubMed id 12972613)1, 9 Zhang Y. and Dufau M.L. (2003)
    9. Immunohistochemistry of COUP-TFI: an adjuvant diagnos tic tool for the identification of corticotroph microadenomas. (PubMed id 19526345)1, 9 Bush Z.M....Vance M.L. (2010)
    10. Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1. (PubMed id 12551987)1, 9 Yu X. and Mertz J.E. (2003)

    External Searches for NR2F1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing NR2F1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7025 HGNC: 7975 AceView: NR2F1 Ensembl:ENSG00000175745 euGenes: HUgn7025
    ECgene: NR2F1 H-InvDB: NR2F1

    Other Databases showing NR2F1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NR2F1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR2F1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NR2F1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NR2F1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NR2F1 gene:
    Search GeneIP for patents involving NR2F1

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