Aliases for NR2E1 Gene
External Ids for NR2E1 Gene
Previous Symbols for NR2E1 Gene
GeneCards Summary for NR2E1 Gene
NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1) is a Protein Coding gene. Diseases associated with NR2E1 include lymphoid leukemia. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding and histone deacetylase binding. An important paralog of this gene is RXRG.
UniProtKB/Swiss-Prot for NR2E1 Gene
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5-AAGGTCA-3 in which the 5 flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells.