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Aliases for NR2C2AP Gene

Aliases for NR2C2AP Gene

  • Nuclear Receptor 2C2-Associated Protein 2 3
  • TR4 Orphan Receptor-Associated 16 KDa Protein 3 4
  • TR4 Orphan Receptor Associated Protein TRA16 2 3
  • TRA16 3 4
  • Repressor For TR4 Transactivation 3

External Ids for NR2C2AP Gene

Previous GeneCards Identifiers for NR2C2AP Gene

  • GC19M019174
  • GC19M019312
  • GC19M018875

Summaries for NR2C2AP Gene

GeneCards Summary for NR2C2AP Gene

NR2C2AP (Nuclear Receptor 2C2-Associated Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for NR2C2AP Gene

  • May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2C2AP Gene

Genomics for NR2C2AP Gene

Regulatory Elements for NR2C2AP Gene

Genomic Location for NR2C2AP Gene

Start:
19,201,414 bp from pter
End:
19,203,429 bp from pter
Size:
2,016 bases
Orientation:
Minus strand

Genomic View for NR2C2AP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR2C2AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2C2AP Gene

Proteins for NR2C2AP Gene

  • Protein details for NR2C2AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WQ0-NR2CA_HUMAN
    Recommended name:
    Nuclear receptor 2C2-associated protein
    Protein Accession:
    Q86WQ0
    Secondary Accessions:
    • A6NGP7
    • B4DW92

    Protein attributes for NR2C2AP Gene

    Size:
    139 amino acids
    Molecular mass:
    15876 Da
    Quaternary structure:
    • Interacts with NR2C2/TR4.

    Alternative splice isoforms for NR2C2AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2C2AP Gene

Proteomics data for NR2C2AP Gene at MOPED

Post-translational modifications for NR2C2AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR2C2AP Gene

No data available for DME Specific Peptides for NR2C2AP Gene

Domains for NR2C2AP Gene

Protein Domains for NR2C2AP Gene

Graphical View of Domain Structure for InterPro Entry

Q86WQ0

UniProtKB/Swiss-Prot:

NR2CA_HUMAN :
  • Q86WQ0
Family:
  • Belongs to the NR2C2AP family.
genes like me logo Genes that share domains with NR2C2AP: view

No data available for Gene Families for NR2C2AP Gene

Function for NR2C2AP Gene

Molecular function for NR2C2AP Gene

UniProtKB/Swiss-Prot Function: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.

Gene Ontology (GO) - Molecular Function for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22486638
genes like me logo Genes that share ontologies with NR2C2AP: view

miRNA for NR2C2AP Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NR2C2AP Gene

Localization for NR2C2AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2C2AP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR2C2AP Gene COMPARTMENTS Subcellular localization image for NR2C2AP gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NR2C2AP: view

Pathways for NR2C2AP Gene

genes like me logo Genes that share pathways with NR2C2AP: view

Pathways by source for NR2C2AP Gene

Gene Ontology (GO) - Biological Process for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007155 cell adhesion --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NR2C2AP: view

Transcripts for NR2C2AP Gene

Unigene Clusters for NR2C2AP Gene

Nuclear receptor 2C2-associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2AP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for NR2C2AP Gene

GeneLoc Exon Structure for
NR2C2AP
ECgene alternative splicing isoforms for
NR2C2AP

Expression for NR2C2AP Gene

mRNA expression in normal human tissues for NR2C2AP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NR2C2AP Gene

SOURCE GeneReport for Unigene cluster for NR2C2AP Gene Hs.708153

mRNA Expression by UniProt/SwissProt for NR2C2AP Gene

Q86WQ0-NR2CA_HUMAN
Tissue specificity: Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with NR2C2AP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NR2C2AP Gene

Orthologs for NR2C2AP Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2C2AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2C2AP 35
  • 99.52 (n)
  • 98.56 (a)
NR2C2AP 36
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NR2C2AP 35
  • 87.92 (n)
  • 90.58 (a)
NR2C2AP 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR2C2AP 35
  • 89.21 (n)
  • 92.09 (a)
NR2C2AP 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2c2ap 35
  • 83.21 (n)
  • 82.73 (a)
Nr2c2ap 16
Nr2c2ap 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2C2AP 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr2c2ap 35
  • 81.85 (n)
  • 80.2 (a)
chicken
(Gallus gallus)
Aves NR2C2AP 35
  • 66.67 (n)
  • 67.01 (a)
NR2C2AP 36
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nr2c2ap 35
  • 61.35 (n)
  • 63.04 (a)
nr2c2ap 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34213 35
  • 51.37 (n)
  • 45.08 (a)
CG34213 36
  • 40 (a)
OneToOne
Species with no ortholog for NR2C2AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR2C2AP Gene

ENSEMBL:
Gene Tree for NR2C2AP (if available)
TreeFam:
Gene Tree for NR2C2AP (if available)

Paralogs for NR2C2AP Gene

No data available for Paralogs for NR2C2AP Gene

Variants for NR2C2AP Gene

Sequence variations from dbSNP and Humsavar for NR2C2AP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1859056 -- 19,202,777(+) GTCGA(A/G)GGAGG intron-variant
rs3177912 -- 19,203,195(+) GGGAC(G/T)AGAAC utr-variant-5-prime
rs8100140 -- 19,203,717(+) gtggc(A/G)cgatc upstream-variant-2KB
rs8101290 -- 19,203,959(+) ttttt(C/T)ttttt upstream-variant-2KB
rs8110634 -- 19,202,994(+) GGCCT(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NR2C2AP Gene

Variant ID Type Subtype PubMed ID
nsv833779 CNV Loss 17160897
nsv911303 CNV Loss 21882294
nsv911304 CNV Loss 21882294
nsv911305 CNV Loss 21882294

Relevant External Links for NR2C2AP Gene

HapMap Linkage Disequilibrium report
NR2C2AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NR2C2AP Gene

Disorders for NR2C2AP Gene

No disorders were found for NR2C2AP Gene.

No data available for UniProtKB/Swiss-Prot for NR2C2AP Gene

Publications for NR2C2AP Gene

  1. Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PMID: 12486131) Yang Y. … Chang C. (J. Biol. Chem. 2003) 2 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. (PMID: 15381082) Lee Y.F. … Chang C. (Biochem. Biophys. Res. Commun. 2004) 3
  4. Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor. (PMID: 17054912) Wang C.P. … Lee H.J. (Biochem. Biophys. Res. Commun. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for NR2C2AP Gene

Sources for NR2C2AP Gene

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