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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR2C2AP Gene

protein-coding   GIFtS: 47
GCID: GC19M019312

Nuclear Receptor 2C2-Associated Protein

  Search for NR2C2AP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Receptor 2C2-Associated Protein1 2
TR4 Orphan Receptor Associated Protein TRA161 2
TRA162 3
TR4 Orphan Receptor-Associated 16 KDa Protein2 3
Repressor For TR4 Transactivation2

External Ids:    HGNC: 307631   Entrez Gene: 1263822   Ensembl: ENSG000001841627   OMIM: 6087195   UniProtKB: Q86WQ03   

Export aliases for NR2C2AP gene to outside databases

Previous GC identifers: GC19M019174 GC19M018875


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NR2C2AP Gene: 
NR2C2AP (nuclear receptor 2C2-associated protein) is a protein-coding gene. Among its related super-pathways are Gene Expression and Nuclear Receptors. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0
Function: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4
and the TR4-response element in target genes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR2C2AP gene promoter:
         SRF   Max1   NRSF form 1   POU3F2   NRSF form 2   c-Ets-1   Roaz   AREB6   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNR2C2AP promoter sequence
   Search SABiosciences Chromatin IP Primers for NR2C2AP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2C2AP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

NR2C2AP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2C2AP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019312:  view genomic region     (about GC identifiers)

Start:
19,312,219 bp from pter      End:
19,314,238 bp from pter
Size:
2,020 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0 (See protein sequence)
Recommended Name: Nuclear receptor 2C2-associated protein  
Size: 139 amino acids; 15876 Da
Subunit: Interacts with NR2C2/TR4
Subcellular location: Nucleus
Secondary accessions: A6NGP7

Explore the universe of human proteins at neXtProt for NR2C2AP: NX_Q86WQ0

Explore proteomics data for NR2C2AP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86WQ0

  • NR2C2AP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NR2C2AP Protein Expression
    REFSEQ proteins: NP_795361.1  
    ENSEMBL proteins: 
     ENSP00000332823   ENSP00000476056   ENSP00000402756   ENSP00000438092   ENSP00000475559  
     ENSP00000476087  
    Reactome Protein details: Q86WQ0
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    Novus Biologicals NR2C2AP Proteins
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for NR2C2AP 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    NR2C2AP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR008979 Galactose-bd-like
     IPR000421 Coagulation_fac_5/8-C_type_dom

    Graphical View of Domain Structure for InterPro Entry Q86WQ0

    ProtoNet protein and cluster: Q86WQ0

    UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0
    Similarity: Belongs to the NR2C2AP family


    NR2C2AP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR2CA_HUMAN, Q86WQ0
    Function: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4
    and the TR4-response element in target genes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    NR2C2AP for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR2C2AP 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidNR2C2AP 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NR2C2AP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    2Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for NR2C2AP
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression



    NR2C2AP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NR2C2AP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for NR2C2AP (Q86WQ03 ENSP000003328234) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR2C2P491163, ENSP000003204474I2D: score=2 STRING: ENSP00000320447
    NR2C1ENSP000003332754STRING: ENSP00000333275
    RARGENSP000003326954STRING: ENSP00000332695
    ESR1ENSP000002062494STRING: ENSP00000206249
    ESR2ENSP000003439254STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007155cell adhesion IEA--
    GO:0010467gene expression TAS--

    NR2C2AP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR2C2AP (NR2CA)

    Search CenterWatch for drugs/clinical trials and news about NR2C2AP / NR2CA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NR2C2AP gene: 
    NM_176880.4  

    Unigene Clusters for NR2C2AP:

    Nuclear receptor 2C2-associated protein
    Hs.708153  [show with all ESTs], Hs.732708  [show with all ESTs]
    Unigene Representative Sequences: NM_176880, BQ221650
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331552(uc002nlx.3) ENST00000590907 ENST00000420605(uc010xqq.1)
    ENST00000537399 ENST00000544883 ENST00000539693 ENST00000538165 ENST00000539678

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    hsa-miR-1266 hsa-miR-4254 hsa-miR-765 hsa-miR-516b* hsa-miR-3914 hsa-miR-218 hsa-miR-3125 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmidNR2C2AP 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: AK301426.1 

    8 DOTS entries:

    DT.100736162  DT.418735  DT.97850302  DT.100799618  DT.95258285  DT.100668792  DT.418738  DT.97780427 

    24/116 AceView cDNA sequences (see all 116):

    AA974321 CA422800 BU689849 AA311632 AA378667 AI281810 BI752134 CB528991 
    AI375221 AA515388 AI283704 AI805698 CR594611 BE275344 BF514097 BM793317 
    BI824739 AI270772 AI280295 CF528510 BU189792 BG676237 AI886590 BG681140 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2AP    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                          -                     
    SP2:                                                
    SP3:                          -                     
    SP4:                          -                     


    ECgene alternative splicing isoforms for NR2C2AP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR2C2AP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCACTCTT
    NR2C2AP Expression
    About this image


    See NR2C2AP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR2C2AP

    SOURCE GeneReport for Unigene clusters: Hs.708153 Hs.732708

    UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0
    Tissue specificity: Expressed in all tissues examined, with highest expression in heart, skeletal muscle and
    pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NR2C2AP gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr2c2ap1 , 5 nuclear receptor 2C2-associated protein1, 5 83.57(n)1
    83.33(a)1
      8 (34.15 cM)5
    756921  NM_001025586.11  NP_001020757.11 
     701313335 
    chicken
    (Gallus gallus)
    Aves LOC1008584011 nuclear receptor 2C2-associated protein-like 66.67(n)
    65.19(a)
      100858401  XM_003642889.1  XP_003642937.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr2c2ap1 nuclear receptor 2C2-associated protein 61.35(n)
    63.04(a)
      724051  NM_001045327.1  NP_001038792.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG342131 CG34213 51.37(n)
    45.08(a)
      5740468  NM_001103969.3  NP_001097439.2 


    ENSEMBL Gene Tree for NR2C2AP (if available)
    TreeFam Gene Tree for NR2C2AP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/71 SNPs in NR2C2AP are shown (see all 71)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893164931,2
    C--19313199(+) AGTGCC/TCTGTG 2 S G mis10--------
    rs1472077441,2
    C,F--19313294(+) GCCCCG/AGCGAC 2 /R /W mis11Minor allele frequency- A:0.00NA 4534
    rs3757170101,2
    C--19313342(+) GACACA/GATGAG 2 R C mis10--------
    rs1512222781,2
    C--19313391(+) TGGAAA/GCAGAC 1 -- int10--------
    rs1926907221,2
    C--19313400(+) ACAGGA/GAAACT 1 -- int10--------
    rs1393643391,2
    --19313475(+) ATGGAC/GGGGAA 1 -- int10--------
    rs2007303211,2
    C--19313585(+) GGTCGA/GGGGAG 1 -- int10--------
    rs18590561,2
    C,F,H--19313586(+) GTCGAG/AGGAGG 1 -- int120Minor allele frequency- A:0.06MN NS EA NA CSA WA EU 3617
    rs2001426451,2
    C--19313801(+) AGGGCC/TTCGCC 1 -- int11Minor allele frequency- T:0.00EU 1323
    rs81106341,2
    C,F--19313803(+) GGCCTC/TGCCAC 1 -- int11Minor allele frequency- T:0.00EU 1323

    HapMap Linkage Disequilibrium report for NR2C2AP (19312219 - 19314238 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NR2C2AP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911304CNV Loss21882294
    nsv833779CNV Loss17160897
    nsv911305CNV Loss21882294
    nsv911303CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NR2C2AP for disorders           About MalaCards
    OMIM gene information: 608719    OMIM disorders: --


    NR2C2AP for disorders           About GeneDecksing


    Export disorders for NR2C2AP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR2C2AP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NR2C2AP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PubMed id 12486131)1, 2, 3, 9 Yang Y.... Chang C. (2003)
    2. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor. (PubMed id 17054912)1 Wang C.P....Lee H.J. (2006)
    6. Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. (PubMed id 15381082)1 Lee Y.F....Chang C. (2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126382 HGNC: 30763 AceView: TRA16 Ensembl:ENSG00000184162 euGenes: HUgn126382
    ECgene: NR2C2AP H-InvDB: NR2C2AP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR2C2AP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NR2C2AP gene:
    Search GeneIP for patents involving NR2C2AP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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