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Aliases for NR2C2AP Gene

Aliases for NR2C2AP Gene

  • Nuclear Receptor 2C2 Associated Protein 2 3
  • TR4 Orphan Receptor-Associated 16 KDa Protein 3 4
  • TR4 Orphan Receptor Associated Protein TRA16 2 3
  • TRA16 3 4
  • Nuclear Receptor 2C2-Associated Protein 5
  • Repressor For TR4 Transactivation 3

External Ids for NR2C2AP Gene

Previous GeneCards Identifiers for NR2C2AP Gene

  • GC19M019174
  • GC19M019312
  • GC19M018875

Summaries for NR2C2AP Gene

GeneCards Summary for NR2C2AP Gene

NR2C2AP (Nuclear Receptor 2C2 Associated Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Nuclear Receptor transcription pathway.

UniProtKB/Swiss-Prot for NR2C2AP Gene

  • May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2C2AP Gene

Genomics for NR2C2AP Gene

Regulatory Elements for NR2C2AP Gene

Enhancers for NR2C2AP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NR2C2AP on UCSC Golden Path with GeneCards custom track

Promoters for NR2C2AP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NR2C2AP on UCSC Golden Path with GeneCards custom track

Genomic Location for NR2C2AP Gene

Chromosome:
19
Start:
19,201,409 bp from pter
End:
19,203,435 bp from pter
Size:
2,027 bases
Orientation:
Minus strand

Genomic View for NR2C2AP Gene

Genes around NR2C2AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR2C2AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR2C2AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2C2AP Gene

Proteins for NR2C2AP Gene

  • Protein details for NR2C2AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WQ0-NR2CA_HUMAN
    Recommended name:
    Nuclear receptor 2C2-associated protein
    Protein Accession:
    Q86WQ0
    Secondary Accessions:
    • A6NGP7
    • B4DW92

    Protein attributes for NR2C2AP Gene

    Size:
    139 amino acids
    Molecular mass:
    15876 Da
    Quaternary structure:
    • Interacts with NR2C2/TR4.

    Alternative splice isoforms for NR2C2AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2C2AP Gene

Proteomics data for NR2C2AP Gene at MOPED

Post-translational modifications for NR2C2AP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NR2C2AP Gene

No data available for DME Specific Peptides for NR2C2AP Gene

Domains & Families for NR2C2AP Gene

Protein Domains for NR2C2AP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86WQ0

UniProtKB/Swiss-Prot:

NR2CA_HUMAN :
  • Belongs to the NR2C2AP family.
Family:
  • Belongs to the NR2C2AP family.
genes like me logo Genes that share domains with NR2C2AP: view

No data available for Gene Families for NR2C2AP Gene

Function for NR2C2AP Gene

Molecular function for NR2C2AP Gene

UniProtKB/Swiss-Prot Function:
May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.
genes like me logo Genes that share phenotypes with NR2C2AP: view

Animal Model Products

CRISPR Products

miRNA for NR2C2AP Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NR2C2AP Gene

Localization for NR2C2AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2C2AP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR2C2AP Gene COMPARTMENTS Subcellular localization image for NR2C2AP gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NR2C2AP: view

Pathways & Interactions for NR2C2AP Gene

genes like me logo Genes that share pathways with NR2C2AP: view

Pathways by source for NR2C2AP Gene

Gene Ontology (GO) - Biological Process for NR2C2AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with NR2C2AP: view

No data available for SIGNOR curated interactions for NR2C2AP Gene

Drugs & Compounds for NR2C2AP Gene

No Compound Related Data Available

Transcripts for NR2C2AP Gene

Unigene Clusters for NR2C2AP Gene

Nuclear receptor 2C2-associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2AP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: -
SP4: -

Relevant External Links for NR2C2AP Gene

GeneLoc Exon Structure for
NR2C2AP
ECgene alternative splicing isoforms for
NR2C2AP

Expression for NR2C2AP Gene

mRNA expression in normal human tissues for NR2C2AP Gene

Protein differential expression in normal tissues from HIPED for NR2C2AP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.5) and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NR2C2AP Gene



SOURCE GeneReport for Unigene cluster for NR2C2AP Gene Hs.708153

mRNA Expression by UniProt/SwissProt for NR2C2AP Gene

Q86WQ0-NR2CA_HUMAN
Tissue specificity: Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas.
genes like me logo Genes that share expression patterns with NR2C2AP: view

Protein tissue co-expression partners for NR2C2AP Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NR2C2AP Gene

Orthologs for NR2C2AP Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2C2AP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NR2C2AP 35
  • 87.92 (n)
  • 90.58 (a)
NR2C2AP 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR2C2AP 35
  • 89.21 (n)
  • 92.09 (a)
NR2C2AP 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2c2ap 35
  • 83.21 (n)
  • 82.73 (a)
Nr2c2ap 16
Nr2c2ap 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NR2C2AP 35
  • 99.52 (n)
  • 98.56 (a)
NR2C2AP 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr2c2ap 35
  • 81.85 (n)
  • 80.2 (a)
oppossum
(Monodelphis domestica)
Mammalia NR2C2AP 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves NR2C2AP 35
  • 66.67 (n)
  • 67.01 (a)
NR2C2AP 36
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nr2c2ap 35
  • 61.35 (n)
  • 63.04 (a)
nr2c2ap 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34213 35
  • 51.37 (n)
  • 45.08 (a)
CG34213 36
  • 40 (a)
OneToOne
Species with no ortholog for NR2C2AP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NR2C2AP Gene

ENSEMBL:
Gene Tree for NR2C2AP (if available)
TreeFam:
Gene Tree for NR2C2AP (if available)

Paralogs for NR2C2AP Gene

No data available for Paralogs for NR2C2AP Gene

Variants for NR2C2AP Gene

Sequence variations from dbSNP and Humsavar for NR2C2AP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8100140 -- 19,203,717(+) gtggc(A/G)cgatc upstream-variant-2KB
rs8101290 -- 19,203,959(+) ttttt(C/T)ttttt upstream-variant-2KB
rs12982158 -- 19,205,298(+) TAAGC(A/C)AAGGC upstream-variant-2KB
rs8110634 -- 19,202,994(+) GGCCT(C/T)GCCAC intron-variant
rs140519538 -- 19,202,498(+) GAGAA(A/G)CCACC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NR2C2AP Gene

Variant ID Type Subtype PubMed ID
nsv833779 CNV Loss 17160897
nsv911303 CNV Loss 21882294
nsv911304 CNV Loss 21882294
nsv911305 CNV Loss 21882294

Variation tolerance for NR2C2AP Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NR2C2AP Gene

Disorders for NR2C2AP Gene

Relevant External Links for NR2C2AP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR2C2AP

No disorders were found for NR2C2AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NR2C2AP Gene

Publications for NR2C2AP Gene

  1. Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PMID: 12486131) Yang Y. … Chang C. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Testicular orphan nuclear receptor 4-associated protein 16 promotes non-small cell lung carcinoma by activating estrogen receptor I^ and blocking testicular orphan nuclear receptorA 2. (PMID: 23129017) Fang F. … Yang Y. (Oncol. Rep. 2013) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for NR2C2AP Gene

Sources for NR2C2AP Gene

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