NR2C2AP Gene
protein-coding GIFtS: 46
GCID: GC19M019312
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nuclear receptor 2C2-associated protein
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Aliases
for NR2C2AP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor 2C2-Associated Protein1 2 | | TRA161 2 3 | | TR4 Orphan Receptor-Associated 16 KDa Protein2 3 | | Repressor For TR4 Transactivation2 | | TR4 Orphan Receptor Associated Protein TRA162 |
Export aliases for NR2C2AP gene to outside databasesPrevious GC identifers: GC19M019174 GC19M018875 |
Summaries
for NR2C2AP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0Function: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and theTR4-response element in target genes
|
Genomic Views
for NR2C2AP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NR2C2AP gene promoter:
SRF Max1 NRSF form 1 POU3F2 NRSF form 2 c-Ets-1 Roaz AREB6 Pax-4a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for NR2C2AP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2C2AP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11NR2C2AP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M019312: view genomic region
(about GC identifiers)
Start:
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19,312,218 bp from pter |
End:
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19,314,238 bp from pter |
Size:
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2,021 bases |
Orientation:
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minus strand |
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Proteins
for NR2C2AP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0 (See
protein sequence)Recommended Name: Nuclear receptor 2C2-associated protein Size: 139 amino acids; 15876 Da
Subunit: Interacts with NR2C2/TR4
Subcellular location: Nucleus
Secondary accessions: A6NGP7Explore the universe of human proteins at neXtProt for NR2C2AP: NX_Q86WQ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86WQ0
NR2C2AP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_795361.1
ENSEMBL proteins: ENSP00000468570 ENSP00000332823 ENSP00000402756 ENSP00000468300 ENSP00000438092 Reactome Protein details: Q86WQ0
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- |
NR2C2AP for ontologies About GeneDecksing
NR2C2AP Antibody Products:
Assay Products for NR2C2AP: |
Protein
Domains /
Families
for NR2C2AP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NR2C2AP for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86WQ0ProtoNet protein and cluster: Q86WQ0 UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0Similarity: Belongs to the NR2C2AP family |
Function
for NR2C2AP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0Function: May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and theTR4-response element in target genes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2AP (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2AP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for NR2C2AP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C2AP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C2AP |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- | | GO:0005515 | protein binding |
IPI | -- |
NR2C2AP for ontologies About GeneDecksing
|
Pathways & Interactions
for NR2C2AP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | Nuclear Receptor transcription pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for NR2C2AP
NR2C2AP for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NR2C2AP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/34 Interacting proteins for NR2C2AP (Q86WQ03 ENSP000003328234) via UniProtKB, MINT, STRING, and/or I2D (see all 34)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0007155 | cell adhesion |
IEA | -- | | GO:0010467 | gene expression |
TAS | -- |
NR2C2AP for ontologies About GeneDecksing
|
Drugs & Compounds
for NR2C2AP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NR2C2AP
Search CenterWatch for drugs/clinical trials and news about NR2C2AP / NR2CA
|
Transcripts
for NR2C2AP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NR2C2AP gene: NM_176880.4 Unigene Clusters for NR2C2AP: Nuclear receptor 2C2-associated protein Hs.708153 [show with all ESTs], Hs.732708 [show with all ESTs]Unigene Representative Sequences: NM_176880, BQ2216509 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589148 ENST00000590907 ENST00000331552(uc002nlx.3) ENST00000420605(uc010xqq.1)
ENST00000537399 ENST00000544883 ENST00000539693 ENST00000538165 ENST00000539678
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2AP (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2AP
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NR2C2AP (NM_176880) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR2C2AP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C2AP |
Additional cDNA sequence: AK301426.1 8 DOTS entries: DT.100736162 DT.418735 DT.97850302 DT.100799618 DT.95258285 DT.100668792 DT.418738 DT.97780427 24/116 AceView cDNA sequences (see all 116): AI270772 BG676237 CF528510 AI886590 AA378667 BM793317 AA974321 CR594611 CA422800 BI824739 AI375221 CB528991 BI829387 BI752134 AI281810 AA515388 BE275344 BG681140 AI805698 BF514097 AA311632 BU689849 BU189792 AI280295
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2AP About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
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| SP1: | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for NR2C2AP
|
Expression
for NR2C2AP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NR2C2AP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCACTCTT
About this image
See NR2C2AP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR2C2AP
SOURCE GeneReport for Unigene clusters: Hs.708153 Hs.732708
UniProtKB/Swiss-Prot: NR2CA_HUMAN, Q86WQ0Tissue specificity: Expressed in all tissues examined, with highest expression in heart, skeletal muscle and pancreas
SABiosciences Custom PCR Arrays for NR2C2AP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR2C2AP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NR2C2AP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR2C2AP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR2C2AP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C2AP |
Orthologs
for NR2C2AP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NR2C2AP gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for NR2C2AP (if available)
TreeFam Gene Tree for NR2C2AP (if available) |
Paralogs
for NR2C2AP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NR2C2AP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NR2C2AP (19312218 - 19314238 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NR2C2AP: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR2C2AP |
|
Disorders
/ Diseases
for NR2C2AP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 NR2C2AP for disorders About MalaCards
NR2C2AP for disorders About GeneDecksing
OMIM gene information: 608719
OMIM disorders: --
Export disorders for NR2C2AP gene to outside databases
|
Publications
for NR2C2AP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NR2C2AP gene integrated from 9 sources:
(articles sorted by number of sources associating them with NR2C2AP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PubMed id 12486131)1, 2, 3, 9 Yang Y.... Chang C. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor. (PubMed id 17054912)1 Wang C.P....Lee H.J. (2006)
- Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. (PubMed id 15381082)1 Lee Y.F....Chang C. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for NR2C2AP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NR2C2AP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NR2C2AP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NR2C2AP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NR2C2AP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NR2C2AP gene:
Search GeneIP for patents involving NR2C2AP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NR2C2AP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NR2C2AP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR2C2AP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR2C2AP | | | OriGene Protein Over-expression Lysate for NR2C2AP | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for NR2C2AP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2AP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2AP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NR2C2AP | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NR2C2AP | | OriGene Custom Protein Services for NR2C2AP | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NR2C2AP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR2C2AP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2C2AP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR2C2AP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR2C2AP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR2C2AP |
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 | | | NR2C2AP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C2AP |
|  |  |  | | | | Search ThermoFisher Antibodies for NR2C2AP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C2AP |
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