NR2C2 Gene
protein-coding GIFtS: 60
GCID: GC03P014989
|
|
nuclear receptor subfamily 2, group C, member 2
(Previous symbol: TR4)
| |
Aliases
for NR2C2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Subfamily 2, Group C, Member 21 2 | | Orphan Nuclear Receptor TR42 3 | | TAK11 2 3 5 | | Testicular Receptor 42 3 | | TR41 2 3 5 | | Nuclear Hormone Receptor TR42 | | TR2R11 2 | | Nuclear Receptor Subfamily 2 Group C Member 22 | | HTAK11 | | Testicular Nuclear Receptor 42 | | Orphan Nuclear Receptor TAK12 3 | | TR4 Nuclear Hormone Receptor2 |
Export aliases for NR2C2 gene to outside databasesPrevious GC identifers: GC03P014918 GC03P014964 |
Summaries
for NR2C2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NR2C2:
Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. Theproteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and aligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where itbinds to hormone response elements of target genes (Yoshikawa et al., 1996 (PubMed 8661150)).(supplied by OMIM, Mar2008)
UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor ofnuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormonereceptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis.Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonicand fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development andembryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important forneurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist ofPPARA-mediated transactivation
Gene Wiki entry for NR2C2 (Testicular receptor 4)
|
Genomic Views
for NR2C2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NR2C2 gene promoter:
TBP Sp1 SREBP-1c LCR-F1 SREBP-1b SREBP-1a Zic3 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NR2C2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2C2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25NR2C2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P014989: view genomic region
(about GC identifiers)
Start:
|
14,989,091 bp from pter |
End:
|
15,095,107 bp from pter |
Size:
|
106,017 bases |
Orientation:
|
plus strand |
|
Proteins
for NR2C2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116 (See
protein sequence)Recommended Name: Nuclear receptor subfamily 2 group C member 2 Size: 596 amino acids; 65414 Da
Subunit: Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF;the interaction preferentially occurs on the non-phosphorylated form and induces NR2C2-mediated transactivationactivity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated form) with NRIP1; theinteraction promotes repression of NR2C2-mediated activity (By similarity). Interacts with NR2C2AP; the interactionrepresses selective NR2C2-mediated transcriptional activity. Interacts with NLRP10
Subcellular location: Nucleus
Developmental stage: Transiently repressed during the meiotic phase of spermatogenesis
1 PDB 3D structure from  and Proteopedia  for NR2C2:3P0U (3D)
Secondary accessions: A8K3H5 B6ZGT8 P55092Alternative splicing: 2 isoforms: P49116-1 P49116-2 Explore the universe of human proteins at neXtProt for NR2C2: NX_P49116
Post-translational modifications:
Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity.Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas thenon-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49116
NR2C2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003289.2
ENSEMBL proteins: ENSP00000402272 ENSP00000388387 ENSP00000391473 ENSP00000320447 ENSP00000376814 ENSP00000401807 ENSP00000412473 ENSP00000413438 ENSP00000384463 Reactome Protein details: P49116
Human Recombinant Protein Products for NR2C2:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NR2C2 for ontologies About GeneDecksing
NR2C2 Antibody Products:
Assay Products for NR2C2: |
Protein
Domains /
Families
for NR2C2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NR2C2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49116ProtoNet protein and cluster: P49116 2 Blocks protein families: IPB000324 Vitamin D receptor signature IPB001723 Steroid hormone receptor signature
UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain |
Function
for NR2C2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NR2C2_HUMAN, P49116Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor ofnuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormonereceptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis.Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonicand fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development andembryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important forneurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist ofPPARA-mediated transactivationInduction: Induced by oxidative stress via FOXO3 activation Genatlas biochemistry entry for NR2C2:nuclear receptor subfamily 2,group C,member 2,with two isoforms short TR4ORA2,long TR4ORA1,predominantly expressed ingranule cell of the hippocampus and cerebellum,steroid/thyroid hormone receptor superfamily
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
NR2C2 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for NR2C2:
10 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Nr2c2):
NR2C2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for NR2C2: Nr2c2tm1Chc Nr2c2tm1Amj
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NR2C2 (NM_003298) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR2C2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C2 |
|
Pathways & Interactions
for NR2C2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nuclear Receptor transcription pathway | | | 2 | Generic Transcription Pathway | | | 3 | TNF-alpha/NF-kB Signaling Pathway | | | 4 | Regulation of Androgen receptor activity | | | 5 | Androgen receptor signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4  BioSystems Pathways for NR2C2
3 
Reactome Pathways for NR2C2
NR2C2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR2C2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/614 Interacting proteins for NR2C2 (P491162, 3 ENSP000003204474) via UniProtKB, MINT, STRING, and/or I2D (see all 614)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
NR2C2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NR2C2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NR2C2 for compounds About GeneDecksing
 Browse Tocris compounds for NR2C2
6 Novoseek chemical compound relationships for NR2C2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| chloramphenicol |
57.7 |
8 |
9006963 (1), 11478808 (1), 9115296 (1), 9704574 (1) (see all 6) |
| retinoid |
44.5 |
5 |
10201524 (2), 7779113 (1), 9593676 (1) |
| retinoic acid |
40.9 |
26 |
15381082 (6), 9593676 (3), 10201524 (3), 19131575 (2) (see all 5) |
| steroid |
25.9 |
4 |
11478808 (1), 7708055 (1), 9593676 (1), 10611280 (1) |
| estrogen |
18.6 |
3 |
11844790 (2), 9593676 (1) |
| testosterone |
0 |
1 |
10611280 (1) |
Search CenterWatch for drugs/clinical trials and news about NR2C2
|
Transcripts
for NR2C2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NR2C2 gene: NM_003298.3 Unigene Cluster for NR2C2: Nuclear receptor subfamily 2, group C, member 2 Hs.555973 [show with all ESTs]Unigene Representative Sequence: NM_00329812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000413118 ENST00000425241 ENST00000435454 ENST00000323373(uc003bzi.3 uc003bzj.4)
ENST00000475707 ENST00000393102 ENST00000437120 ENST00000478572 ENST00000439011
ENST00000495282 ENST00000413194 ENST00000406272
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NR2C2 (NM_003298) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR2C2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C2 |
Additional cDNA sequence: AB307708.1 AK091226.1 AK290590.1 BC030715.1 BC051670.1 HQ995528.1 L27586.1 16 DOTS entries: DT.444322 DT.100662886 DT.92423867 DT.99993633 DT.87046741 DT.91947308 DT.120877885 DT.120877800 DT.95156885 DT.100803869 DT.40218598 DT.100646796 DT.120877729 DT.91855210 DT.92063306 DT.95101645 24/185 AceView cDNA sequences (see all 185): CB242238 AI218732 BX438248 AW519049 AA346914 BU753108 AL699042 BF435204 AI868278 AW515099 CA417464 AW873651 AI024815 AA600370 AW511431 BQ018101 AI741676 BM990178 BM708429 R62465 BI254970 BQ022729 AA365060 CR614431
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NR2C2
|
Expression
for NR2C2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NR2C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTAGCTTT
About this image
See NR2C2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR2C2
SOURCE GeneReport for Unigene cluster: Hs.555973
SABiosciences Expression via Pathway-Focused PCR Arrays including NR2C2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR2C2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NR2C2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR2C2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR2C2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C2 |
Orthologs
for NR2C2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NR2C2 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NR2C21 |
nuclear receptor subfamily 2, group C, member 2 |
81.18(n)
92.61(a) |
|
395253 XM_414462.3 XP_414462.3 |
lizard
(Anolis carolinensis) |
Reptilia |
NR2C26 |
-- |
92(a) |
1 ↔ 1 |
2(170798248-170839101) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX693252.12 |
-- |
76.62(n) |
|
BX693252.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
nr2c21 |
nuclear receptor subfamily 2, group C, member 2 |
72.81(n)
81.22(a) |
|
569321 NM_001123294.1 NP_001116766.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Hr783 |
ligand-dependent nuclear receptor |
68(a) |
|
3 78D4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
nhr-2366nhr-416(see all 5) |
Nuclear hormone receptor family member nhr-41(see all 5) |
27(a)20(a)(see all 5) |
possible ortholog1 ↔ many(see all 5) |
IV(2327126-2329640) IV(1386162-1399352) |
ENSEMBL Gene Tree for NR2C2 (if available)
TreeFam Gene Tree for NR2C2 (if available) |
Paralogs
for NR2C2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NR2C2 gene
- ESRRA2 RXRG2 PGR2 ESR22 ESRRB2 HNF4G2 NR2F62 NR2E12
- ESRRG2 NR3C22 RXRA2 NR2F12 NR3C12 NR2F22 AR2 ESR12
- NR2C12 HNF4A2 RXRB2
18/26 SIMAP similar genes for NR2C2 using alignment to 8 protein entries: NR2C2_HUMAN (see all proteins)
(see all similar genes):RXRB HNF4G NR6A1 HNF4alpha NR1F1 RORA
ESRRB NR2C1 NR5A1 NR5A2 ESR2 THRB
NR3C2 ESR1 RARB NR2F1 NR1H3 VDR
NR2C2 for paralogs About GeneDecksing
|
Genomic Variants
for NR2C2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NR2C2 (14989091 - 15095107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NR2C2
2 CNVs: 2441 3418 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR2C2 |
|
Disorders
/ Diseases
for NR2C2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NR2C2 for disorders About GeneDecksing
OMIM gene information: 601426
OMIM disorders: --
10  diseases for NR2C2: About MalaCardsteratocarcinoma cockayne syndrome hepatitis b lung cancer
hepatitis immunodeficiency thyroiditis neuronitis
pancreatic cancer pancreatitis
2 Novoseek disease relationships for NR2C2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| teratocarcinoma |
53.7 |
4 |
15381082 (1), 9593676 (1) |
| cancer |
0 |
3 |
19787075 (1) |
Human Genome Epidemiology (HuGE) Navigator: NR2C2 (4 documents)
Export disorders for NR2C2 gene to outside databases
|
Publications
for NR2C2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NR2C2 gene, integrated from 9 sources (see all 87):
(articles sorted by number of sources associating them with NR2C2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. (PubMed id 8016112)1, 2, 3 Chang C....Burbach J.P. (1994)
- TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. (PubMed id 7708055)1, 2, 9 Hirose T.... Jetten A.M. (1994)
- Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PubMed id 12486131)1, 2, 9 Yang Y.... Chang C. (2003)
- New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene. (PubMed id 8661150)1, 3, 9 Yoshikawa T....Detera-Wadleigh S.D. (1996)
- The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. (PubMed id 17974920)1, 2, 9 Tanabe O....Engel J.D. (2007)
- Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PubMed id 10644740)1, 2, 9 Zhang Y. and Dufau M.L. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human testicular orphan receptor 4 enhances thyroid h ormone receptor signaling. (PubMed id 19859911)1, 9 Huang Y.H....Lin K.H. (2010)
- Activation of TR4 orphan nuclear receptor gene promot er by cAMP/PKA and C/EBP signaling. (PubMed id 19618297)1, 9 Liu N.C....Chang C. (2009)
- Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a. (PubMed id 18388194)2, 9 Li G....Chang C. (2008)
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External Searches for NR2C2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NR2C2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NR2C2 gene
(According to HUGE)
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Specialized Databases showing NR2C2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for NR2C2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NR2C2 gene:
Search GeneIP for patents involving NR2C2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NR2C2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for NR2C2 | | OriGene shRNA RFP for NR2C2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR2C2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR2C2 | | | OriGene Protein Over-expression Lysate for NR2C2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NR2C2 | | OriGene 3'-UTR Clone for NR2C2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NR2C2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NR2C2 | | OriGene Custom Protein Services for NR2C2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NR2C2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR2C2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2C2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NR2C2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR2C2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR2C2 |
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| | | | Search Tocris compounds for NR2C2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NR2C2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C2 |
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