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NR2C2 Gene

protein-coding   GIFtS: 63
GCID: GC03P014989

Nuclear Receptor Subfamily 2, Group C, Member 2


(Previous symbol: TR4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Receptor Subfamily 2, Group C, Member 21 2     TR2R12
TR41 2 3 5     hTAK12
TAK12 3 5     Nuclear Hormone Receptor TR42
Orphan Nuclear Receptor TAK12 3     Nuclear Receptor Subfamily 2 Group C Member 22
Orphan Nuclear Receptor TR42 3     Testicular Nuclear Receptor 42
Testicular Receptor 42 3     TR4 Nuclear Hormone Receptor2

External Ids:    HGNC: 79721   Entrez Gene: 71822   Ensembl: ENSG000001774637   OMIM: 6014265   UniProtKB: P491163   

Export aliases for NR2C2 gene to outside databases

Previous GC identifers: GC03P014918 GC03P014964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NR2C2 Gene:
Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The
proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a
ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus
where it binds to hormone response elements of target genes (Yoshikawa et al., 1996 (PubMed 8661150)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for NR2C2 Gene:
NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is RXRA.

UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116
Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important
repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor,
thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of
spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex
that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response
elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental
role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum
development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates
transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation

Gene Wiki entry for NR2C2 (Testicular receptor 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NR2C2 gene promoter:
         TBP   Sp1   SREBP-1c   LCR-F1   SREBP-1b   SREBP-1a   Zic3   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR2C2 promoter sequence
   Search Chromatin IP Primers for NR2C2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NR2C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25

NR2C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2C2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P014989:  view genomic region     (about GC identifiers)

Start:
14,989,091 bp from pter      End:
15,095,107 bp from pter
Size:
106,017 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 2 group C member 2  
Size: 596 amino acids; 65414 Da
Subunit: Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1
required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with
PCAF; the interaction preferentially occurs on the non-phosphorylated form and induces NR2C2-mediated
transactivation activity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated
form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (By similarity). Interacts with
NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity. Interacts with NLRP10
Developmental stage: Transiently repressed during the meiotic phase of spermatogenesis
1 PDB 3D structure from and Proteopedia for NR2C2:
3P0U (3D)    
Secondary accessions: A8K3H5 B6ZGT8 P55092
Alternative splicing: 2 isoforms:  P49116-1   P49116-2   

Explore the universe of human proteins at neXtProt for NR2C2: NX_P49116

Explore proteomics data for NR2C2 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity.
    Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas
    the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NR2C2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003289.2  
    ENSEMBL proteins: 
     ENSP00000402272   ENSP00000388387   ENSP00000391473   ENSP00000320447   ENSP00000376814  
     ENSP00000401807   ENSP00000412473   ENSP00000413438   ENSP00000384463  
    Reactome Protein details: P49116

    NR2C2 Human Recombinant Protein Products:

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    Novus Biologicals NR2C2 Proteins
    Novus Biologicals NR2C2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NR2C2 

    NR2C2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for NR2C2
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NR2C2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Testicular receptor 4
    2C. Testicular receptors

    5 InterPro protein domains:
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P49116

    ProtoNet protein and cluster: P49116

    2 Blocks protein domains:
    IPB000324 Vitamin D receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    Find genes that share domains with NR2C2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR2C2_HUMAN, P49116
    Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important
    repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor,
    thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of
    spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex
    that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response
    elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental
    role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum
    development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates
    transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation
    Induction: Induced by oxidative stress via FOXO3 activation

         Genatlas biochemistry entry for NR2C2:
    nuclear receptor subfamily 2,group C,member 2,with two isoforms short TR4ORA2,long TR4ORA1,predominantly expressed
    in granule cell of the hippocampus and cerebellum,steroid/thyroid hormone receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10644740
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003713transcription coactivator activity TAS9006963
    GO:0004872receptor activity TAS9006963
         
    Find genes that share ontologies with NR2C2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NR2C2:
     Abundance of large cells with   Increased gamma-H2AX phosphory 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nr2c2):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  reproductive system 

    Find genes that share phenotypes with NR2C2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NR2C2: Nr2c2tm1Chc Nr2c2tm1Amj

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NR2C2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NR2C2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR2C2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR2C2

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GAGGTCAAAGGTCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NR2C2:
    hsa-mir-21-5p (MIRT030801), hsa-mir-615-3p (MIRT039640)

    Block miRNA regulation of human, mouse, rat NR2C2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NR2C2 (see all 153):
    hsa-miR-579 hsa-miR-520f hsa-miR-1224-3p hsa-miR-106a hsa-miR-938 hsa-miR-342-3p hsa-miR-3921 hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NR2C2

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NR2C2 (NM_003298)
    Sino Biological Human cDNA Clone for NR2C2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NR2C2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for NR2C2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NR2C2_HUMAN, P49116: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with NR2C2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NR2C2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    4TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    5TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway


    Find genes that share SuperPaths with NR2C2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for NR2C2
        Nuclear Receptors
    Androgen receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    Regulation of Androgen receptor activity

    2 Sino Biological Pathways for NR2C2
        Non-Canonical Wnt Pathway
    TGF-beta Signaling Pathway

    1 Reactome Pathway for NR2C2
        Nuclear Receptor transcription pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR2C2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NR2C2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NR2C2 (P491162, 3 ENSP000003204474) via UniProtKB, MINT, STRING, and/or I2D (see all 651)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AB1P082382, 3, ENSP000003258754MINT-7945693 I2D: score=1 STRING: ENSP00000325875
    ARCN1P484442, 3MINT-7945693 I2D: score=3 
    THOC2Q8NI272, 3MINT-7945693 I2D: score=3 
    ENSG00000206289P287023I2D: score=3 
    ENSG00000227322P287023I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated TAS9006963
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007283spermatogenesis IEA--
    GO:0007399nervous system development TAS9006963

    Find genes that share ontologies with NR2C2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NR2C2

    2 IUPHAR Ligands for NR2C2 (Testicular receptor 4)    About this table
    LigandTypeActionAffinityPubmed IDs
    retinol
    AgonistFull agonist21068381
    all-trans-retinoic acid
    AgonistFull agonist21068381

    6 Novoseek inferred chemical compound relationships for NR2C2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloramphenicol 57.7 8 9006963 (1), 11478808 (1), 9115296 (1), 9704574 (1) (see all 6)
    retinoid 44.5 5 10201524 (2), 7779113 (1), 9593676 (1)
    retinoic acid 40.9 26 15381082 (6), 9593676 (3), 10201524 (3), 19131575 (2) (see all 5)
    steroid 25.9 4 11478808 (1), 7708055 (1), 9593676 (1), 10611280 (1)
    estrogen 18.6 3 11844790 (2), 9593676 (1)
    testosterone 0 1 10611280 (1)



    Find genes that share compounds with NR2C2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NR2C2 gene: 
    NM_003298.3  

    Unigene Cluster for NR2C2:

    Nuclear receptor subfamily 2, group C, member 2
    Hs.555973  [show with all ESTs]
    Unigene Representative Sequence: NM_003298
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413118 ENST00000425241 ENST00000435454 ENST00000323373(uc003bzi.3 uc003bzj.4)
    ENST00000475707 ENST00000393102 ENST00000437120 ENST00000478572 ENST00000439011
    ENST00000495282 ENST00000413194 ENST00000406272
    miRNA
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    hsa-miR-579 hsa-miR-520f hsa-miR-1224-3p hsa-miR-106a hsa-miR-938 hsa-miR-342-3p hsa-miR-3921 hsa-miR-208b
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat NR2C2

    Additional mRNA sequence: 

    AB307708.1 AK091226.1 AK290590.1 BC030715.1 BC051670.1 HQ995528.1 L27586.1 

    18 DOTS entries:

    DT.444322  DT.100662886  DT.92423867  DT.99993633  DT.87046741  DT.91947308  DT.120877885  DT.120877800 
    DT.95156885  DT.100803869  DT.40218598  DT.99984153  DT.100646796  DT.100748637  DT.120877729  DT.91855210 
    DT.92063306  DT.95101645 

    Selected AceView cDNA sequences (see all 185):

    BQ018101 AA568719 AI741676 AA600370 AI218732 AA365060 BM708429 AA235689 
    BX438248 Z42046 BI254970 AA356181 BF435204 BQ022729 AW873651 F01569 
    AA330632 AW515099 AA255737 CD678956 BM990178 AI283071 NM_003298 BC030715 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -                                         -                       -                                       
    SP2:              -     -                                   -                       -                                       
    SP3:                                                                                -                                       
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for NR2C2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NR2C2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTAGCTTT
    NR2C2 Expression
    About this image

    NR2C2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NR2C2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555973
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NR2C2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NR2C2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr2c21 , 5 nuclear receptor subfamily 2, group C, member 21, 5 92.56(n)1
    98.32(a)1
      6 (41.03 cM)5
    220261  NM_011630.31  NP_035760.11 
     920913905 
    chicken
    (Gallus gallus)
    Aves NR2C21 nuclear receptor subfamily 2, group C, member 2 81.18(n)
    92.61(a)
      395253  XM_004944725.1  XP_004944782.1 
    lizard
    (Anolis carolinensis)
    Reptilia NR2C26
    nuclear receptor subfamily 2, group C, member 2
    87(a)
    1 ↔ 1
    2(170790524-170839101)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX693252.12   -- 76.62(n)    BX693252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr2c21 nuclear receptor subfamily 2, group C, member 2 72.81(n)
    81.22(a)
      569321  NM_001123294.1  NP_001116766.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hr783 ligand-dependent nuclear receptor 68(a)   3 78D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-416
    Protein NHR-41 (nhr-41) mRNA, complete cds
    25(a)
    1 → many
    IV(1386163-1399353) WBGene00022423


    ENSEMBL Gene Tree for NR2C2 (if available)
    TreeFam Gene Tree for NR2C2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NR2C2 gene
    RXRA2  RXRG2  NR2F12  NR2F22  HNF4G2  NR2C12  NR2F62  NR2E12  
    HNF4A2  RXRB2  
    Selected SIMAP similar genes for NR2C2 using alignment to 8 protein entries:     NR2C2_HUMAN (see all proteins) (see all similar genes):
    RXRB    HNF4G    NR6A1    HNF4alpha    NR1F1    RORA
    ESRRB    NR2C1    NR5A1    NR5A2    ESR2    THRB
    NR3C2    ESR1    RARB    NR2F1    NR1H3    VDR

    Find genes that share paralogs with NR2C2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NR2C2 (see all 1977)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891197531,2
    --14991988(+) ACACAC/GTGGCC 1 -- int10--------
    rs1811610301,2
    C--14991993(+) CTGGCC/TTACCT 1 -- int10--------
    rs1508773371,2
    --14992000(+) ACCTTC/TAACTT 1 -- int10--------
    rs1864886881,2
    --14992074(+) CTCAAC/GCATCA 1 -- int10--------
    rs130970151,2
    C,F--14992135(+) ttattC/Tttttc 1 -- int17Minor allele frequency- T:0.09NA WA EA 366
    rs98804031,2
    C,F--14992214(+) TACCAC/TACTGT 1 -- int13Minor allele frequency- T:0.07WA NA EA 358
    rs1496680971,2
    C--14992354(+) GATGG-/ATACCT 1 -- int10--------
    rs1909339401,2
    C--14992357(+) GGATAA/CCTTTT 1 -- int10--------
    rs1393346201,2
    --14992480(+) TAAATA/GTGGAT 1 -- int10--------
    rs1500641611,2
    --14992608(+) ATGTTA/GTTTAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for NR2C2 (14989091 - 15095107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NR2C2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663121CNV Deletion23128226
    nsv834620CNV Gain17160897
    nsv876580CNV Gain21882294
    essv17407CNV CNV17122850
    dgv1436e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NR2C2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601426    OMIM disorders: --


    Find genes that share disorders with NR2C2           About GenesLikeMe

    2 Novoseek inferred disease relationships for NR2C2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teratocarcinoma 53.7 4 15381082 (1), 9593676 (1)
    cancer 0 3 19787075 (1)

    Genetic Association Database (GAD): NR2C2
    Human Genome Epidemiology (HuGE) Navigator: NR2C2 (4 documents)

    Export disorders for NR2C2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NR2C2 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with NR2C2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. (PubMed id 8016112)1, 2, 3 Chang C.... Burbach J.P. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. (PubMed id 7708055)1, 2, 9 Hirose T.... Jetten A.M. (Mol. Endocrinol. 1994)
    3. Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PubMed id 12486131)1, 2, 9 Yang Y.... Chang C. (J. Biol. Chem. 2003)
    4. New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene. (PubMed id 8661150)1, 3, 9 Yoshikawa T....Detera-Wadleigh S.D. (Genomics 1996)
    5. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. (PubMed id 17974920)1, 2, 9 Tanabe O....Engel J.D. (Genes Dev. 2007)
    6. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PubMed id 10644740)1, 2, 9 Zhang Y. and Dufau M.L. (J. Biol. Chem. 2000)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    9. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7182 HGNC: 7972 AceView: NR2C2 Ensembl:ENSG00000177463 euGenes: HUgn7182
    ECgene: NR2C2 H-InvDB: NR2C2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NR2C2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NR2C2 gene:
    Search GeneIP for patents involving NR2C2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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