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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NR2C2 Gene

protein-coding   GIFtS: 62
GCID: GC03P014989

Nuclear Receptor Subfamily 2, Group C, Member 2


(Previous symbol: TR4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Receptor Subfamily 2, Group C, Member 21 2     TR2R12
TR41 2 3 5     hTAK12
TAK12 3 5     Nuclear Hormone Receptor TR42
Orphan Nuclear Receptor TAK12 3     Nuclear Receptor Subfamily 2 Group C Member 22
Orphan Nuclear Receptor TR42 3     Testicular Nuclear Receptor 42
Testicular Receptor 42 3     TR4 Nuclear Hormone Receptor2

External Ids:    HGNC: 79721   Entrez Gene: 71822   Ensembl: ENSG000001774637   OMIM: 6014265   UniProtKB: P491163   

Export aliases for NR2C2 gene to outside databases

Previous GC identifers: GC03P014918 GC03P014964


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR2C2 Gene:
Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The
proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a
ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus
where it binds to hormone response elements of target genes (Yoshikawa et al., 1996 (PubMed 8661150)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for NR2C2 Gene: 
NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein-coding gene. Diseases associated with NR2C2 include teratocarcinoma, and hepatitis b, and among its related super-pathways are Nuclear Receptors and Gene Expression. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NR5A2.

UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116
Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important
repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor,
thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of
spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex
that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response
elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental
role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum
development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates
transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation

Gene Wiki entry for NR2C2 (Testicular receptor 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR2C2 gene promoter:
         TBP   Sp1   SREBP-1c   LCR-F1   SREBP-1b   SREBP-1a   Zic3   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NR2C2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NR2C2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25

NR2C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR2C2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P014989:  view genomic region     (about GC identifiers)

Start:
14,989,091 bp from pter      End:
15,095,107 bp from pter
Size:
106,017 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 2 group C member 2  
Size: 596 amino acids; 65414 Da
Subunit: Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1
required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with
PCAF; the interaction preferentially occurs on the non-phosphorylated form and induces NR2C2-mediated
transactivation activity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated
form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (By similarity). Interacts with
NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity. Interacts with NLRP10
Subcellular location: Nucleus
Developmental stage: Transiently repressed during the meiotic phase of spermatogenesis
1 PDB 3D structure from and Proteopedia for NR2C2:
3P0U (3D)    
Secondary accessions: A8K3H5 B6ZGT8 P55092
Alternative splicing: 2 isoforms:  P49116-1   P49116-2   

Explore the universe of human proteins at neXtProt for NR2C2: NX_P49116

Explore proteomics data for NR2C2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity.
    Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas
    the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49116

  • NR2C2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NR2C2 Protein Expression
    REFSEQ proteins: NP_003289.2  
    ENSEMBL proteins: 
     ENSP00000402272   ENSP00000388387   ENSP00000391473   ENSP00000320447   ENSP00000376814  
     ENSP00000401807   ENSP00000412473   ENSP00000413438   ENSP00000384463  
    Reactome Protein details: P49116
    Human Recombinant Protein Products for NR2C2: 
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    Novus Biologicals NR2C2 Proteins
    Novus Biologicals NR2C2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    NR2C2 for ontologies           About GeneDecksing



    NR2C2 Antibody Products: 
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    Abcam antibodies for NR2C2
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Testicular receptor 4 
    2C. Testicular receptors

    5 InterPro protein domains:
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P49116

    ProtoNet protein and cluster: P49116

    2 Blocks protein domains:
    IPB000324 Vitamin D receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: NR2C2_HUMAN, P49116
    Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    NR2C2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NR2C2_HUMAN, P49116
    Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important
    repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor,
    thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of
    spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex
    that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response
    elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental
    role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum
    development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates
    transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation
    Induction: Induced by oxidative stress via FOXO3 activation

         Genatlas biochemistry entry for NR2C2:
    nuclear receptor subfamily 2,group C,member 2,with two isoforms short TR4ORA2,long TR4ORA1,predominantly expressed
    in granule cell of the hippocampus and cerebellum,steroid/thyroid hormone receptor superfamily

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10644740
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003713transcription coactivator activity TAS9006963
    GO:0004872receptor activity TAS9006963
         
    NR2C2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NR2C2:
     Abundance of large cells with   Increased gamma-H2AX phosphory 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nr2c2):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  reproductive system 

    NR2C2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NR2C2: Nr2c2tm1Chc Nr2c2tm1Amj

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NR2C2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NR2C2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NR2C2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NR2C2 

    miRNA
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    8/153 QIAGEN miScript miRNA Assays for microRNAs that regulate NR2C2 (see all 153):
    hsa-miR-579 hsa-miR-520f hsa-miR-1224-3p hsa-miR-106a hsa-miR-938 hsa-miR-342-3p hsa-miR-3921 hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for NR2C2
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                         Customized lentivirus expression plasmids for stable overexpression of NR2C2 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NR2C2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    Nuclear Receptors0.68
    2Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    3Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    4TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    5TGF-beta Signaling Pathway
    TGF-beta Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for NR2C2
        Nuclear Receptors
    Androgen receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    Regulation of Androgen receptor activity

    2 Sino Biological Pathways for NR2C2 
        Non-Canonical Wnt Pathway
    TGF-beta Signaling Pathway

    3        Reactome Pathways for NR2C2
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Gene Expression



    NR2C2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR2C2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/648 Interacting proteins for NR2C2 (P491162, 3 ENSP000003204474) via UniProtKB, MINT, STRING, and/or I2D (see all 648)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AB1P082382, 3, ENSP000003258754MINT-7945693 I2D: score=1 STRING: ENSP00000325875
    ARCN1P484442, 3MINT-7945693 I2D: score=3 
    THOC2Q8NI272, 3MINT-7945693 I2D: score=3 
    ENSG00000206289P287023I2D: score=3 
    ENSG00000227322P287023I2D: score=3 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent TAS9006963
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007283spermatogenesis IEA--
    GO:0007399nervous system development TAS9006963

    NR2C2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NR2C2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR2C2

    2 IUPHAR Ligands for NR2C2 (Testicular receptor 4)    About this table 
    LigandTypeActionAffinityPubmed IDs
    retinol
    AgonistFull agonist21068381
    all-trans-retinoic acid
    AgonistFull agonist21068381

    6 Novoseek inferred chemical compound relationships for NR2C2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloramphenicol 57.7 8 9006963 (1), 11478808 (1), 9115296 (1), 9704574 (1) (see all 6)
    retinoid 44.5 5 10201524 (2), 7779113 (1), 9593676 (1)
    retinoic acid 40.9 26 15381082 (6), 9593676 (3), 10201524 (3), 19131575 (2) (see all 5)
    steroid 25.9 4 11478808 (1), 7708055 (1), 9593676 (1), 10611280 (1)
    estrogen 18.6 3 11844790 (2), 9593676 (1)
    testosterone 0 1 10611280 (1)

    Search CenterWatch for drugs/clinical trials and news about NR2C2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NR2C2 gene: 
    NM_003298.3  

    Unigene Cluster for NR2C2:

    Nuclear receptor subfamily 2, group C, member 2
    Hs.555973  [show with all ESTs]
    Unigene Representative Sequence: NM_003298
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413118 ENST00000425241 ENST00000435454 ENST00000323373(uc003bzi.3 uc003bzj.4)
    ENST00000475707 ENST00000393102 ENST00000437120 ENST00000478572 ENST00000439011
    ENST00000495282 ENST00000413194 ENST00000406272
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    Additional mRNA sequence: 

    AB307708.1 AK091226.1 AK290590.1 BC030715.1 BC051670.1 HQ995528.1 L27586.1 

    18 DOTS entries:

    DT.444322  DT.100662886  DT.92423867  DT.99993633  DT.87046741  DT.91947308  DT.120877885  DT.120877800 
    DT.95156885  DT.100803869  DT.40218598  DT.99984153  DT.100646796  DT.100748637  DT.120877729  DT.91855210 
    DT.92063306  DT.95101645 

    24/185 AceView cDNA sequences (see all 185):

    BM696613 BM790678 AL699042 AA346914 AA356181 Z42046 AW519049 AA600370 
    AA330632 AA365060 AA255737 NM_003298 AL138444 AA235689 AI283071 AI024815 
    AA330633 BQ423396 AW873651 BM990178 CR614431 AW469842 BE221766 BU753108 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -                                         -                       -                                       
    SP2:              -     -                                   -                       -                                       
    SP3:                                                                                -                                       
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for NR2C2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NR2C2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTAGCTTT
    NR2C2 Expression
    About this image


    See NR2C2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NR2C2

    SOURCE GeneReport for Unigene cluster: Hs.555973
        SABiosciences Expression via Pathway-Focused PCR Arrays including NR2C2: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NR2C2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nr2c21 , 5 nuclear receptor subfamily 2, group C, member 21, 5 92.56(n)1
    98.32(a)1
      6 (41.03 cM)5
    220261  NM_011630.31  NP_035760.11 
     920913905 
    chicken
    (Gallus gallus)
    Aves NR2C21 nuclear receptor subfamily 2, group C, member 2 81.18(n)
    92.61(a)
      395253  XM_414462.3  XP_414462.3 
    lizard
    (Anolis carolinensis)
    Reptilia NR2C26
    Uncharacterized protein
    87(a)
    1 ↔ 1
    2(170790524-170839101)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX693252.12   -- 76.62(n)    BX693252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nr2c21 nuclear receptor subfamily 2, group C, member 2 72.81(n)
    81.22(a)
      569321  NM_001123294.1  NP_001116766.1 


    ENSEMBL Gene Tree for NR2C2 (if available)
    TreeFam Gene Tree for NR2C2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NR2C2 gene
    NR5A22  RXRA2  RXRG2  NR2F12  NR5A12  NR2F22  NR2C12  HNF4G2  
    NR2F62  NR2E12  HNF4A2  RXRB2  NR6A12  
    18/26 SIMAP similar genes for NR2C2 using alignment to 8 protein entries:     NR2C2_HUMAN (see all proteins) (see all similar genes):
    RXRB    HNF4G    NR6A1    HNF4alpha    NR1F1    RORA
    ESRRB    NR2C1    NR5A1    NR5A2    ESR2    THRB
    NR3C2    ESR1    RARB    NR2F1    NR1H3    VDR

    NR2C2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1977 SNPs in NR2C2 are shown (see all 1977)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891197531,2
    --14991988(+) ACACAC/GTGGCC 1 -- int10--------
    rs1811610301,2
    C--14991993(+) CTGGCC/TTACCT 1 -- int10--------
    rs1508773371,2
    --14992000(+) ACCTTC/TAACTT 1 -- int10--------
    rs1864886881,2
    --14992074(+) CTCAAC/GCATCA 1 -- int10--------
    rs130970151,2
    C,F--14992135(+) ttattC/Tttttc 1 -- int17Minor allele frequency- T:0.09NA WA EA 366
    rs98804031,2
    C,F--14992214(+) TACCAC/TACTGT 1 -- int13Minor allele frequency- T:0.07WA NA EA 358
    rs1496680971,2
    C--14992354(+) GATGG-/ATACCT 1 -- int10--------
    rs1909339401,2
    C--14992357(+) GGATAA/CCTTTT 1 -- int10--------
    rs1393346201,2
    --14992480(+) TAAATA/GTGGAT 1 -- int10--------
    rs1500641611,2
    --14992608(+) ATGTTA/GTTTAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for NR2C2 (14989091 - 15095107 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NR2C2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663121CNV Deletion23128226
    nsv834620CNV Gain17160897
    nsv876580CNV Gain21882294
    essv17407CNV CNV17122850
    dgv1436e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601426    OMIM disorders: --

    9 diseases for NR2C2:    About MalaCards
    teratocarcinoma    hepatitis b    pancreatic cancer    alcoholism
    thyroiditis    pancreatitis    tuberculosis    hepatitis
    lung cancer


    NR2C2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NR2C2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teratocarcinoma 53.7 4 15381082 (1), 9593676 (1)
    cancer 0 3 19787075 (1)

    Genetic Association Database (GAD): NR2C2
    Human Genome Epidemiology (HuGE) Navigator: NR2C2 (4 documents)

    Export disorders for NR2C2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NR2C2 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with NR2C2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. (PubMed id 8016112)1, 2, 3 Chang C....Burbach J.P. (1994)
    2. TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. (PubMed id 7708055)1, 2, 9 Hirose T.... Jetten A.M. (1994)
    3. Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PubMed id 12486131)1, 2, 9 Yang Y.... Chang C. (2003)
    4. New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene. (PubMed id 8661150)1, 3, 9 Yoshikawa T....Detera-Wadleigh S.D. (1996)
    5. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. (PubMed id 17974920)1, 2, 9 Tanabe O....Engel J.D. (2007)
    6. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PubMed id 10644740)1, 2, 9 Zhang Y. and Dufau M.L. (2000)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    9. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7182 HGNC: 7972 AceView: NR2C2 Ensembl:ENSG00000177463 euGenes: HUgn7182
    ECgene: NR2C2 H-InvDB: NR2C2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NR2C2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NR2C2 gene:
    Search GeneIP for patents involving NR2C2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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