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Aliases for NR2C2 Gene

Aliases for NR2C2 Gene

  • Nuclear Receptor Subfamily 2, Group C, Member 2 2 3
  • TAK1 3 4 6
  • TR4 3 4 6
  • Orphan Nuclear Receptor TAK1 3 4
  • Orphan Nuclear Receptor TR4 3 4
  • Nuclear Receptor Subfamily 2 Group C Member 2 3
  • Testicular Nuclear Receptor 4 3
  • Nuclear Hormone Receptor TR4 3
  • Testicular Receptor 4 4

External Ids for NR2C2 Gene

Previous Symbols for NR2C2 Gene

  • TR4

Summaries for NR2C2 Gene

Entrez Gene Summary for NR2C2 Gene

  • This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

GeneCards Summary for NR2C2 Gene

NR2C2 (Nuclear Receptor Subfamily 2, Group C, Member 2) is a Protein Coding gene. Among its related pathways are TGF-beta Signaling Pathway (sino) and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is RXRG.

UniProtKB/Swiss-Prot for NR2C2 Gene

  • Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5-AGGTCA-3 half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

Gene Wiki entry for NR2C2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR2C2 Gene

Genomics for NR2C2 Gene

Genomic Location for NR2C2 Gene

Start:
14,947,584 bp from pter
End:
15,053,600 bp from pter
Size:
106,017 bases
Orientation:
Plus strand

Genomic View for NR2C2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NR2C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR2C2 Gene

Regulatory Elements for NR2C2 Gene

Proteins for NR2C2 Gene

  • Protein details for NR2C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49116-NR2C2_HUMAN
    Recommended name:
    Nuclear receptor subfamily 2 group C member 2
    Protein Accession:
    P49116
    Secondary Accessions:
    • A8K3H5
    • B6ZGT8
    • P55092

    Protein attributes for NR2C2 Gene

    Size:
    596 amino acids
    Molecular mass:
    65414 Da
    Quaternary structure:
    • Homodimer; can bind DNA as homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C1 required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with PCAF; the interaction preferentially occurs on the non-phosphorylated form and induces NR2C2-mediated transactivation activity and does not require the ligand-binding domain. Interacts (MAPK-mediated phosphorylated form) with NRIP1; the interaction promotes repression of NR2C2-mediated activity (By similarity). Interacts with NR2C2AP; the interaction represses selective NR2C2-mediated transcriptional activity. Interacts with NLRP10.

    Three dimensional structures from OCA and Proteopedia for NR2C2 Gene

    Alternative splice isoforms for NR2C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR2C2 Gene

Proteomics data for NR2C2 Gene at MOPED

Post-translational modifications for NR2C2 Gene

  • Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NR2C2 Gene

Domains for NR2C2 Gene

Gene Families for NR2C2 Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

UniProtKB/Swiss-Prot:

NR2C2_HUMAN
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.:
    • P49116
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.:
    • P49116
genes like me logo Genes that share domains with NR2C2: view

Function for NR2C2 Gene

Molecular function for NR2C2 Gene

GENATLAS Biochemistry: nuclear receptor subfamily 2,group C,member 2,with two isoforms short TR4ORA2,long TR4ORA1,predominantly expressed in granule cell of the hippocampus and cerebellum,steroid/thyroid hormone receptor superfamily
UniProtKB/Swiss-Prot Function: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5-AGGTCA-3 half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
UniProtKB/Swiss-Prot Induction: Induced by oxidative stress via FOXO3 activation.

Gene Ontology (GO) - Molecular Function for NR2C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 10644740
GO:0003707 steroid hormone receptor activity IEA --
GO:0003713 transcription coactivator activity TAS 9006963
GO:0004872 receptor activity TAS 9006963
genes like me logo Genes that share ontologies with NR2C2: view
genes like me logo Genes that share phenotypes with NR2C2: view

Animal Models for NR2C2 Gene

MGI Knock Outs for NR2C2:

miRNA for NR2C2 Gene

miRTarBase miRNAs that target NR2C2
Targeting motifs for NR2C2 Gene
HOMER Transcription Factor Regulatory Elements motif NR2C2
  • Consensus sequence: GAGGTCAAAGGTCA Submotif: DR1 Cell Type: Hela GeoId: GSE24685

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for NR2C2 Gene

Localization for NR2C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR2C2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR2C2 Gene COMPARTMENTS Subcellular localization image for NR2C2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NR2C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with NR2C2: view

Pathways for NR2C2 Gene

genes like me logo Genes that share pathways with NR2C2: view

Gene Ontology (GO) - Biological Process for NR2C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated TAS 9006963
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007283 spermatogenesis IEA --
GO:0007399 nervous system development TAS 9006963
genes like me logo Genes that share ontologies with NR2C2: view

Compounds for NR2C2 Gene

(2) IUPHAR Ligand for NR2C2 Gene

Ligand Type Action Affinity Pubmed IDs
all-trans-retinoic acid Agonist Agonist 9.4
retinol Agonist Full agonist

(6) Novoseek inferred chemical compound relationships for NR2C2 Gene

Compound -log(P) Hits PubMed IDs
chloramphenicol 57.7 6
retinoid 44.5 4
retinoic acid 40.9 15
steroid 25.9 4
estrogen 18.6 3
genes like me logo Genes that share compounds with NR2C2: view

Transcripts for NR2C2 Gene

Unigene Clusters for NR2C2 Gene

Nuclear receptor subfamily 2, group C, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR2C2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for NR2C2 Gene

GeneLoc Exon Structure for
NR2C2
ECgene alternative splicing isoforms for
NR2C2

Expression for NR2C2 Gene

mRNA expression in normal human tissues for NR2C2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NR2C2 Gene

SOURCE GeneReport for Unigene cluster for NR2C2 Gene Hs.555973

genes like me logo Genes that share expressions with NR2C2: view

Orthologs for NR2C2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR2C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NR2C2 36
  • 99.62 (n)
  • 99.84 (a)
NR2C2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NR2C2 36
  • 90.64 (n)
  • 97.7 (a)
NR2C2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR2C2 36
  • 94.52 (n)
  • 98.99 (a)
NR2C2 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr2c2 36
  • 92.56 (n)
  • 98.32 (a)
Nr2c2 16
Nr2c2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NR2C2 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NR2C2 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr2c2 36
  • 91.89 (n)
  • 97.82 (a)
chicken
(Gallus gallus)
Aves NR2C2 36
  • 81.18 (n)
  • 92.61 (a)
NR2C2 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NR2C2 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr2c2 36
  • 78.26 (n)
  • 89.24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5700 36
zebrafish
(Danio rerio)
Actinopterygii nr2c2 36
  • 72.81 (n)
  • 81.22 (a)
nr2c2 37
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hr78 37
  • 26 (a)
OneToMany
Hr78 38
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea nhr-41 37
  • 25 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4782 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9698 37
  • 34 (a)
OneToMany
Species with no ortholog for NR2C2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR2C2 Gene

ENSEMBL:
Gene Tree for NR2C2 (if available)
TreeFam:
Gene Tree for NR2C2 (if available)

Paralogs for NR2C2 Gene

Paralogs for NR2C2 Gene

genes like me logo Genes that share paralogs with NR2C2: view

Variants for NR2C2 Gene

Sequence variations from dbSNP and Humsavar for NR2C2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs545114 -- 15,040,689(+) CTTCT(A/G)TTGCC intron-variant
rs596827 -- 15,035,004(-) AAAGG(C/T)TCCAT intron-variant
rs612051 -- 15,033,853(-) TGAAA(C/T)GTAAA intron-variant
rs648912 -- 15,043,362(+) TGTGT(A/G)TATAT utr-variant-3-prime
rs748120 -- 14,993,932(+) CAAGG(A/G)ACAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NR2C2 Gene

Variant ID Type Subtype PubMed ID
dgv1436e1 CNV Complex 17122850
nsv876580 CNV Gain 21882294
nsv834620 CNV Gain 17160897
essv17407 CNV CNV 17122850
esv2663121 CNV Deletion 23128226

Relevant External Links for NR2C2 Gene

HapMap Linkage Disequilibrium report
NR2C2

Disorders for NR2C2 Gene

(2) Novoseek inferred disease relationships for NR2C2 Gene

Disease -log(P) Hits PubMed IDs
teratocarcinoma 53.7 2
cancer 0 1

Relevant External Links for NR2C2

Genetic Association Database (GAD)
NR2C2
Human Genome Epidemiology (HuGE) Navigator
NR2C2
genes like me logo Genes that share disorders with NR2C2: view

No data available for UniProtKB/Swiss-Prot for NR2C2 Gene

Publications for NR2C2 Gene

  1. New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene. (PMID: 8661150) Yoshikawa T. … Detera-Wadleigh S.D. (Genomics 1996) 2 3 23
  2. TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. (PMID: 7708055) Hirose T. … Jetten A.M. (Mol. Endocrinol. 1994) 3 4 23
  3. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. (PMID: 10644740) Zhang Y. … Dufau M.L. (J. Biol. Chem. 2000) 3 4 23
  4. Identification of a novel testicular orphan receptor-4 (TR4)- associated protein as repressor for the selective suppression of TR4- mediated transactivation. (PMID: 12486131) Yang Y. … Chang C. (J. Biol. Chem. 2003) 3 4 23
  5. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. (PMID: 17974920) Tanabe O. … Engel J.D. (Genes Dev. 2007) 3 4 23

Products for NR2C2 Gene

Sources for NR2C2 Gene

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