NR2C1 Gene
protein-coding GIFtS: 60
GCID: GC12M095414
|
|
nuclear receptor subfamily 2, group C, member 1
(Previous symbol: TR2)
| |
Aliases
for NR2C1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear Receptor Subfamily 2, Group C, Member 11 2 | | Nuclear Receptor Subfamily 2 Group C Member 12 | | TR21 2 3 | | Nuclear Receptor Subfamily 2, Group C Isoform2 | | Orphan Nuclear Receptor TR22 3 | | TR2 Nuclear Hormone Receptor2 | | TR2-111 | | Testicular Receptor 23 |
Export aliases for NR2C1 gene to outside databasesPrevious GC identifers: GC12P094483 GC12P9G0092 GC12M095348 GC12M093918 GC12M092481 |
Summaries
for NR2C1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NR2C1:
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variablehinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of thesteroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducibletranscription factors that regulate gene expression by binding to specific DNA sequences within promoters of targetgenes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some ofthese variants has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NR2C1_HUMAN, P13056Function: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negativefeedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs)consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of theDRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Alsoactivator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator ofretinoic acid-regulated preadipocyte proliferation
Gene Wiki entry for NR2C1 (Testicular receptor 2)
|
Genomic Views
for NR2C1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NR2C1 gene promoter:
SRF p53 SRF (504 AA) Egr-1 Pax-2 Pax-2a RORalpha2 PPAR-alpha Pax-2b
Other transcription factors
Search SABiosciences Chromatin IP Primers for NR2C1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NR2C1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q22NR2C1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M095414: view genomic region
(about GC identifiers)
Start:
|
95,414,057 bp from pter |
End:
|
95,467,479 bp from pter |
Size:
|
53,423 bases |
Orientation:
|
minus strand |
|
Proteins
for NR2C1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NR2C1_HUMAN, P13056 (See
protein sequence)Recommended Name: Nuclear receptor subfamily 2 group C member 1 Size: 603 amino acids; 67315 Da
Subunit: Homodimer (By similarity). Heterodimer; binds DNA as a heterodimer with NR2C2 required for chromatinremodeling and for binding to promoter regions such as globin DR1 repeats (By similarity). Interacts with NRIP1 (viaits LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain).Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylationof NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; theinteraction acts as a corepressor of gene expression (By similarity). Interacts with ESR1; the interaction preventshomodimerization of ESR1 and suppresses its transcriptional activity and cell growth
Subcellular location: Nucleus (By similarity). Nucleus, PML body (By similarity). Note=Recruited by HDAC3, afterall-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation(By similarity)
Secondary accessions: A8K5K4 Q15625 Q15626Alternative splicing: 3 isoforms: P13056-1 P13056-2 P13056-3 Explore the universe of human proteins at neXtProt for NR2C1: NX_P13056
Post-translational modifications:
Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies.Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation byall-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequentsumoylation, suppresses OCT4 expression (By similarity)1
Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-222, stimulated by all-trans retinoicacid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association witheffector molecules, KAT2B and NRIP1. Phosphorylation on Ser-581 by PKC is important for protein stability and functionas activator of RARB (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13056
NR2C1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001027458.1 NP_001120834.1 NP_003288.2
ENSEMBL proteins: ENSP00000450225 ENSP00000333275 ENSP00000446817 ENSP00000376813 ENSP00000328843 ENSP00000446906 Reactome Protein details: P13056
Human Recombinant Protein Products for NR2C1:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NR2C1 for ontologies About GeneDecksing
NR2C1 Antibody Products:
Assay Products for NR2C1: |
Protein
Domains /
Families
for NR2C1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NR2C1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P13056ProtoNet protein and cluster: P13056 UniProtKB/Swiss-Prot: NR2C1_HUMAN, P13056Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain |
Function
for NR2C1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NR2C1_HUMAN, P13056Function: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negativefeedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs)consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of theDRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Alsoactivator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator ofretinoic acid-regulated preadipocyte proliferation Genatlas biochemistry entry for NR2C1:nuclear receptor subfamily 2,group C,member 1,expressed in testis and prostate,steroid/thyroid hormone receptorsuperfamily,with several alternative isoforms
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
NR2C1 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for NR2C1:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nr2c1):
NR2C1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): NR2C1 (NM_001127362) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR2C1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C1 |
|
Pathways & Interactions
for NR2C1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | | | 2 | Regulation of Androgen receptor activity | | | 3 | Signaling events mediated by HDAC Class I | | | 4 | Nuclear Receptor transcription pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NR2C1
3 
Reactome Pathways for NR2C1
NR2C1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR2C1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/61 Interacting proteins for NR2C1 (P130562, 3 ENSP000003332754) via UniProtKB, MINT, STRING, and/or I2D (see all 61)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0043401 | steroid hormone mediated signaling pathway |
-- | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
-- | -- |
NR2C1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NR2C1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NR2C1 for compounds About GeneDecksing
 Browse Tocris compounds for NR2C1
5 Novoseek chemical compound relationships for NR2C1 gene About this table
Search CenterWatch for drugs/clinical trials and news about NR2C1
|
Transcripts
for NR2C1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NR2C1 gene (3 alternative transcripts): NM_001032287.2 NM_001127362.1 NM_003297.3 Unigene Cluster for NR2C1: Nuclear receptor subfamily 2, group C, member 1 Hs.108301 [show with all ESTs]Unigene Representative Sequence: NM_00329718 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000551647 ENST00000552861 ENST00000333003(uc001tdm.4 uc010suu.1)
ENST00000549617 ENST00000546416 ENST00000547594 ENST00000552484 ENST00000545833
ENST00000552791 ENST00000393101(uc001tdn.4) ENST00000330677(uc001tdo.4)
ENST00000548252 ENST00000546367 ENST00000548966 ENST00000552417 ENST00000551386
ENST00000549482 ENST00000547469
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NR2C1 (NM_001127362) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NR2C1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NR2C1 |
Additional cDNA sequence: AB307707.1 AK291319.1 BC026074.1 BC040141.1 JQ308177.1 JQ308178.1 M21985.1 M29959.1 M29960.1 18 DOTS entries: DT.99938703 DT.95372907 DT.100794052 DT.100794055 DT.91752983 DT.103246 DT.86846664 DT.121179420 DT.91752985 DT.91752986 DT.100794054 DT.95248466 DT.97840201 DT.121179411 DT.121179462 DT.85104260 DT.97819831 DT.433448 24/147 AceView cDNA sequences (see all 147): AW021046 AL513888 AI080515 AA300579 AA373148 AL525589 AW008437 BU616009 BQ028119 CR590188 AI050052 AU279608 CA310258 BU688702 BM998591 AA953009 BM557938 BM272208 CB154735 AU127636 BC040141 AU130255 AU280557 BM678635
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NR2C1 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | |
| ExUns: | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NR2C1
|
Expression
for NR2C1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NR2C1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NR2C1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NR2C1
SOURCE GeneReport for Unigene cluster: Hs.108301
SABiosciences Expression via Pathway-Focused PCR Array including NR2C1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR2C1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NR2C1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NR2C1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NR2C1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NR2C1 |
Orthologs
for NR2C1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NR2C1 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NR2C11 |
nuclear receptor subfamily 2, group C, member 1 |
76.57(n)
79.79(a) |
|
373913 NM_204124.1 NP_989455.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NR2C16 |
-- |
82(a) |
1 ↔ 1 |
5(30978340-30992532) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.215342 |
Xenopus laevis developmental orphan receptor 2 (DOR2) more |
78.57(n) |
|
AF013295.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
nr2c11 |
nuclear receptor subfamily 2, group C, member 1 |
62.61(n)
63.3(a) |
|
553649 NM_001020622.1 NP_001018458.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Hr783 |
ligand-dependent nuclear receptor |
68(a) |
|
3 78D4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
nhr-2366nhr-416(see all 5) |
Nuclear hormone receptor family member nhr-41(see all 5) |
28(a)20(a)(see all 5) |
possible ortholog1 ↔ many(see all 5) |
IV(2327126-2329640) IV(1386162-1399352) |
ENSEMBL Gene Tree for NR2C1 (if available)
TreeFam Gene Tree for NR2C1 (if available) |
Paralogs
for NR2C1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NR2C1 gene
- ESRRA2 RXRG2 PGR2 ESR22 ESRRB2 HNF4G2 NR2F62 NR2E12
- ESRRG2 NR3C22 RXRA2 NR2F12 NR3C12 NR2F22 AR2 ESR12
- HNF4A2 NR2C22 RXRB2
12 SIMAP similar genes for NR2C1 using alignment to 6 protein entries: NR2C1_HUMAN (see all proteins):HNF4G PPARA RORA NR2C2 HNF4alpha NR5A1
RXRB NR3C2 VDR ESR1 NR1I3 PPARG
NR2C1 for paralogs About GeneDecksing
|
Genomic Variants
for NR2C1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NR2C1 (95414057 - 95467479 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NR2C1
2 CNVs: 5684 49157 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NR2C1 |
|
Disorders
/ Diseases
for NR2C1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NR2C1 for disorders About GeneDecksing
OMIM gene information: 601529
OMIM disorders: --
14  diseases for NR2C1: About MalaCardsthyroiditis fanconi's anemia cryptorchidism atopy
papilloma hepatitis b anemia retinoblastoma
prostate cancer hepatitis prostatitis immunodeficiency
leukemia neuronitis
1 disease from the University of Copenhagen DISEASES database for NR2C1:Blepharophimosis 1 Novoseek disease relationship for NR2C1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
3 |
11358973 (2), 10811662 (1) |
Genetic Association Database (GAD): NR2C1
Human Genome Epidemiology (HuGE) Navigator: NR2C1 (2 documents)
Export disorders for NR2C1 gene to outside databases
|
Publications
for NR2C1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NR2C1 gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with NR2C1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains. (PubMed id 2597158)1, 2, 3 Chang C....Chang Y. (1989)
- Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor. (PubMed id 12093804)1, 2, 9 Hu Y.C....Chang C. (2002)
- Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A. (PubMed id 17010934)1, 2, 9 Lin Y.L....Lee H.J. (2006)
- Identification of a new member of the steroid receptor super-family by cloning and sequence analysis. (PubMed id 3421977)1, 2 Chang C. and Kokontis J. (1988)
- HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. (PubMed id 19204783)1, 9 Gupta P....Wei L.N. (2009)
- Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2. (PubMed id 14521922)1, 9 Li G....Wei L.N. (2003)
- TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3. (PubMed id 12949936)1, 9 Mu X. and Chang C. (2003)
- Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily. (PubMed id 12361719)1, 9 Lee Y.F....Chang C. (2002)
- Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. (PubMed id 12615366)1, 9 Inui S....Chang C. (2003)
- The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. (PubMed id 11463856)1, 9 Franco P.J.... Wei L.-N. (2001)
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External Searches for NR2C1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NR2C1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NR2C1 gene
(According to HUGE)
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Specialized Databases showing NR2C1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for NR2C1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for NR2C1 gene:
Search GeneIP for patents involving NR2C1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NR2C1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NR2C1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NR2C1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NR2C1 | | | OriGene Protein Over-expression Lysate for NR2C1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NR2C1 | | OriGene 3'-UTR Clone for NR2C1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NR2C1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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